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Articles 3061 - 3090 of 5390
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The Freedom Quilt, April Jones
The Freedom Quilt, April Jones
Theses and Dissertations
The Freedom Quilt is a play that I have written and adapted from Deborah Hokinson’s book, Sweet Clara and the Freedom Quilt. This story explores the historic and dramatic implications in the idea of coded quilts as a form of communication among African American slaves; specifically as coded maps to freedom. There is an ongoing scholarly debate challenging the existence of these quilts, let alone that they could have been used in such a complex manner. The Freedom Quilt however, is one girl’s unique and individual story, and does not in any way suggest that maps, encoded in quilts were …
Altruism, Activism, And The Moral Imperative In Craft, Gabriel Craig
Altruism, Activism, And The Moral Imperative In Craft, Gabriel Craig
Theses and Dissertations
I consider myself a metalsmith although my interest in materials and ideas extend beyond the boundaries of traditional practice. I approach my work thematically, meaning that I treat my discipline as a framework for a broad investigation rather than as a skill set or process. The outcomes of this approach are therefore varied and include jewelry, installation, performance, video, interactive community based projects, print and web based writing, and historical research. It is through humor or direct viewer interaction that I promote accessibility in my work. My ideas are layered and communicated in a way that allows viewers to engage …
An Agent Based Gene Flow Model, Erich Foster
An Agent Based Gene Flow Model, Erich Foster
Theses and Dissertations
The understanding of gene movement in plant species is critical to the management of both plant and animal species reliant on that plant. Pollen is the mechanism by which plants pass their genetic material from one generation to the next. Pollen dispersal studies have focused primarily on purely random diffusion processes, while this may be a good assumption for species pollinated mainly by abiotic means, such as wind, it is most likely an over simplification for species that are pollinated by biotic means, such as insects [3]. Correlated random walk (CRW) models are a model of animal movement [10] and …
Tacrolimus Is Not Neuroprotective Against Bilirubin Induced Auditory Impairment, Lori Walker
Tacrolimus Is Not Neuroprotective Against Bilirubin Induced Auditory Impairment, Lori Walker
Theses and Dissertations
In newborns, unconjugated bilirubin (UCB) is not readily excreted, and when bilirubin levels exceed the serum albumin binding capacity, pathological levels of UCB exist. Hyperbilirubinemia may lead to auditory damage and ultimately cause a hearing disorder called auditory neuropathy/dys-synchrony, characterized by absent or abnormal brainstem auditory evoked potentials (BAEPs) with evidence of normal inner ear function assessed by either otoacoustic emissions or cochlear microphonic responses. Phototherapy and double volume exchange transfusion are used as treatment methods for neonatal hyperbilirubinemia. Spontaneously jaundiced Gunn rat pups given sulfadimethoxine to displace bilirubin from serum albumin develop bilirubin encephalopathy and have abnormal BAEPs comparable …
The Politics Of Tea And Theatre: How Women’S Suffrage Groups Used Tea And Theatre To Influence Working And Middle Class Women To Become Politically Active, Lisa Kelly
Theses and Dissertations
In the late nineteenth and early twentieth centuries the members of the woman’s suffrage movement in the United States and Britain looked to soften their hard masculine image given to them by the press and to increase participation in the cause. They found that by including theatrical performances and benefits at meetings, and hosting tea socials afterwards, they could motivate many women to join without alienating or threatening men. This study looks at how tea socials and theatrical performances were used subversively to recruit new members, to debate ideas, and to disseminate information about the cause. Playwrights wrote plays that …
The Second Generation Proteasome Inhibitor Carfilzomib Interacts Synergistically With Hdac Inhibitors In Diffuse Large B-Cell Lymphoma Cells Through Multiple Mechanisms And Circumvents Bortezomib Resistance, Dmitry Lembersky
Theses and Dissertations
Mechanisms underlying the interactions between the proteasome inhibitor carfilzomib and HDAC inhibitors were examined in both germinal center (GC) and activated B-cell (ABC) subtypes of human diffuse large B-cell lymphoma (DLBCL). Simultaneous exposure to minimally toxic concentrations of carfilzomib and HDAC inhibitor vorinostat resulted in the release of mitochondrial pro-apoptotic proteins SMAC and cytochrome c, pro-apoptotic caspase activation, and synergistic induction in apoptosis in both ABC and GC DLBCL subtypes. These events were associated with a marked increase in the stress kinase JNK, ROS generation, G2-M cell cycle arrest, as well as induction of DNA damage. Genetic knockdown of JNK …
Paper Tricks, Edward Gardner
Paper Tricks, Edward Gardner
Theses and Dissertations
Prefabricated post disaster housing
Culture And A Connection, Chris Arias
Culture And A Connection, Chris Arias
Theses and Dissertations
Culture and a Connection In the Spanish province of Asturias, many homes built in the16th and 17th centuries are constructed of dry-stacked stone and large timbers for floor joists, rafters, decking. They are topped with large, irregularly shaped roof slates. Alongside many of these homes stands a rectangular granary called a cabazo. The cabazo, similarly constructed, is a stand-alone structure about twenty feet tall, six feet wide and twenty feet long. The main portion, (the storage area), stands ten feet off the ground atop two large, tapered columns. The upper level is typically separated form the lower level by a …
Legacy, Susana Almuiña
Legacy, Susana Almuiña
Theses and Dissertations
I am interested in family secrets and the rules and mores that may constrain family behavior or adversely affect a member’s destiny. I make work that looks askance at the efforts to hide from the world those events or secrets that reflect badly on a family. I look at the places where I have discovered some of them: family furniture and objects around the house, which can shed, metaphorically, the secrets and stories that are part of family tradition. I focus light on the lives of my uncelebrated ancestors and bring them, however briefly, into the collective consciousness.
A Comparison Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Clozapine And The Glutamate Agonist N-Methyl D-Aspartate In C57bl/6 Mice., Sarah A. Vunck
Theses and Dissertations
The glutamate system dysfunctions present in schizophrenia raise new questions about possible glutamatergic actions of the atypical antipsychotic clozapine. While clozapine has been shown to partially substitute for the discriminative stimulus of the glutamate agonist N-methyl D-aspartate (NMDA) in rats, NMDA discrimination has not previously been established in mice. The present study was designed to explore the possible role of NMDA activity in clozapine’s discriminative stimulus. Two groups of C57BL/6 mice were trained to discriminate either 2.5 mg/kg CLZ from vehicle or 30 mg/kg NMDA from vehicle in a standard two-lever drug discrimination task. NMDA drug discrimination was successfully established …
Examination Of The Discriminative Stimulus And Cross-Tolerance Inducing Properties Of N-Desmethylclozapine In C57bl/6 Mice., Jason Wiebelhaus
Examination Of The Discriminative Stimulus And Cross-Tolerance Inducing Properties Of N-Desmethylclozapine In C57bl/6 Mice., Jason Wiebelhaus
Theses and Dissertations
Due to its unique receptor binding profile and its relationship to clozapine, N-desmethylclozapine (NDMC) has been examined as a possible antipsychotic drug (APD). Clozapine has been trained as discriminative stimulus in our lab, but NDMC has not yet been established as a discriminative stimulus. In experiment 1, 12 C57BL/6 mice were trained to discriminate 10.0 mg/kg NDMC from VEH using a standard-two lever operant procedure to assess antipsychotic substitution. The typical APD clozapine fully substituted for NDMC at 2 doses tested (2.5 and 5.0 mg/kg), while typical APD haloperidol failed to substitute for NDMC. In Experiment 2, 11 mice were …
Obesity, Adiposity, And Satiety In Mouse Models Of Smith-Magenis Syndrome And Dup(17)(P11.2) Syndrome, Brooke Burns
Obesity, Adiposity, And Satiety In Mouse Models Of Smith-Magenis Syndrome And Dup(17)(P11.2) Syndrome, Brooke Burns
Theses and Dissertations
Smith-Magenis syndrome (SMS) is a complex disorder caused by haploinsufficiency of RAI1 and characterized by sleep disturbances, behavioral abnormalities, mental retardation, and obesity in teens and adults. Rai1+/- mice are obese after 20 weeks. Dup(17)(p11.2) syndrome is a complex disorder associated with overexpression of RAI1. A transgenic mouse model of dup(17)(p11.2) syndrome overexpresses Rai1 and results in a mouse that is growth delayed. In order to characterize the obese phenotypes of mouse models of SMS and the role of RAI1 in obesity, daily food intake and serum levels of insulin, glucose, PPY, and leptin were measured; adiposity was studied by …
Role Of Hepatic Cholesterol Ester Hydrolase (Ceh) In Hydrolyzing Cholesterol Esters (Ce) Delivered Via Sr-Bi (Scavenger Receptor Class B Type I) And Sr-Bii, Saurabh Bajpai
Theses and Dissertations
Reduction of cholesterol ester (CE) from lipid burden lesion-associated macrophage foam cells has been shown to reduce plaque volumes. Hydrolysis of CE to free cholesterol (FC) in macrophages is an essential step for removal of CE from the macrophage and its transport to the liver by high density lipoprotein (HDL) for further metabolism. Since CE must again be hydrolyzed into FC in the liver catalyzing this hydrolysis, it becomes imperative to find the identity of these enzymes. In this study the role of key enzyme in catalyzing the hydrolysis of CE to FC, neutral cholesterol ester hydrolase (CEH) was evaluated. …
Steampunk: An Exploration In Design, Christopher Mueller
Steampunk: An Exploration In Design, Christopher Mueller
Theses and Dissertations
The purpose of this thesis is to detail my first professional costume design job after my unofficial graduation in May 2008. This thesis will serve primarily as a design thesis, and will concentrate the majority of its efforts in the presentation of a final, original costume design for a realized production of Sweeney Todd: The Demon Barber of Fleet Street as produced by Duke University. During the course of this presentation, I will seek to detail my own design process and the inspiration and research I used to achieve my goal. I will also discuss the execution of the design, …
Hyperspectral Reflectance For Rapid Viability Assessment Of Bacillus Endospores, Jarrod Edwards
Hyperspectral Reflectance For Rapid Viability Assessment Of Bacillus Endospores, Jarrod Edwards
Theses and Dissertations
A study was conducted to optically determine the viability of the Gram +, endospore-forming bacterial genera Bacillus using a hyperspectral reflectance spectrometer. Endospores are a dormant, differentiated cellular capsule form taken by select bacteria to ensure survival when environmental conditions become unfavorable. Two species of Bacillus were used for this study, Bacillus megaterium and Bacillus subtilis. These endospores were killed using a chemical treatment of sodium hypochlorite or a physical treatment of heat and pressure in an autoclave. The treated samples along with viable samples were lyophilized to form a powder. A reflectance spectrometer measuring 350 nm to 2500 nm …
Multisensory Input To The Lateral Rostral Suprasylvian Sulcus (Lrss) In Ferret, Elizabeth Hagood
Multisensory Input To The Lateral Rostral Suprasylvian Sulcus (Lrss) In Ferret, Elizabeth Hagood
Theses and Dissertations
For the brain to construct a comprehensive percept of the sensory world, information from the different senses must converge onto individual neurons within the central nervous system. As a consequence, how these neurons convert convergent sensory input into multisensory information is an important question facing neuroscience today. Recent physiological studies have demonstrated the presence of a robust population of multisensory neurons in the lateral bank of the rostral suprasylvian sulcus (LRSS) in adult ferret (Keniston et al, 2008). The LRSS is a region situated between somatosensory and auditory cortices, where bimodal (somatosensory-auditory) neurons occupy the greatest percentage of the sensory-responsive …
Efficacy Of A Brief Intervention For Insomnia Among Psychiatric Outpatients, James Nile Wagley
Efficacy Of A Brief Intervention For Insomnia Among Psychiatric Outpatients, James Nile Wagley
Theses and Dissertations
Psychiatric patients are particularly affected by symptoms of insomnia. Because insomnia is often secondary to other conditions and was once thought to be less treatable, this condition has received little attention in terms of treatment and research. Additionally, psychiatric patients have typically fewer resources to seek treatment. Generally, insomnia is treated with medications that may have biological side effects and offer little restorative sleep. Behavioral or cognitive interventions have often been overlooked. This experiment uses profile analysis to test the hypothesis that psychiatric outpatients randomized to a treatment group would have decreased levels of sleep difficulties (measured by PSQI) when …
The Responses Of Blue Crabs (Callinectes Sapidus) To Hypoxia/Hypercapnia In Freshwater, James Martin
The Responses Of Blue Crabs (Callinectes Sapidus) To Hypoxia/Hypercapnia In Freshwater, James Martin
Theses and Dissertations
The present research examined respiratory responses of blue crabs to long term (4, 13, and 21 days) hypercapnic hypoxia in freshwater at 23 C. Hypoxic conditions (50-60 & 75-85 mmHg O2) were induced by allowing the crabs to consume their oxygen supply, resulting in a hypercapnic induced decrease in pH that remained through the exposure. Postbranchial hemolymph responses to hypoxia/hypercapnia in freshwater demonstrate decreases in PO2, increases in PCO2, and decreases in pH. Lactate levels decreased over time, but hemocyanin concentration was highly variable with no trends. PH, lactate, and hemocyanin observations also demonstrated high variability and a variety of …
The Presence Of Amphibian Ranavirus In Virginia Warm Water Fish Hatchery Ponds, Elizabeth Nelson
The Presence Of Amphibian Ranavirus In Virginia Warm Water Fish Hatchery Ponds, Elizabeth Nelson
Theses and Dissertations
Amphibian declines have been occurring world wide over the past several decades. Infectious disease and environmental changes have been implicated as the causative agents in these declines. Fish stocking from hatcheries provides a unique opportunity for organisms, including infectious diseases, to travel over long distances. Ranavirus was previously found in two ponds at Harrison Lake National Fish Hatchery in Charles City County, Virginia. Therefore, the primary objective of this study was to determine if ranavirus is present in tadpoles from four warm water fish hatcheries in Virginia. A secondary objective of this study was to determine if there are relationships …
Matrix Metalloproteinase Expression In Models Of Parkinson's Disease, Justin Mcclain
Matrix Metalloproteinase Expression In Models Of Parkinson's Disease, Justin Mcclain
Theses and Dissertations
Parkinson’s disease (PD) is a devastating neurodegenerative disorder characterized by progressive loss of dopaminergic neurons located in the substantia nigra. Accumulating evidence indicates that microglia-driven neuroinflammation contributes significantly to chronic neurodegeneration in PD. The matrix metalloproteinases (MMPs) play an important role in several neuroinflammatory paradigms; however, their relationship to dopaminergic neurodegeneration in PD remains relatively unexplored. To address this, the temporal relationship between MMP-2, MMP-3, MMP-9, and MMP-13 expression and dopaminergic neurodegeneration was compared in the 6-hydroxydopamine (6-OHDA) and lipopolysaccharide (LPS) models of PD. In dopaminergic SH-SY5Y cells, 6-OHDA treatment significantly increased MMP-13 mRNA expression; however, examination of 6-OHDA-lesioned rats …
The Role Of Myeloid-Derived Suppressor Cells In The Immunotherapy Of Breast Carcinomas, Johanna Morales
The Role Of Myeloid-Derived Suppressor Cells In The Immunotherapy Of Breast Carcinomas, Johanna Morales
Theses and Dissertations
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells at various stages of differentiation. These cells are broadly characterized by the simultaneous expression of the surface markers CD11b and Gr1 and have been found to accumulate in large numbers in response to many different tumors in both mice and humans, including HER2/neu+ breast cancers. The adoptive immunotherapy of cancers has been a promising field, yet the clinical efficacy of adoptive immunotherapies targeted against human breast cancers and many other cancers has been extremely limited. Given the influx of MDSC in tumor-bearing individuals, we hypothesized that these cells were …
The Role Of Mitogen-Activated Protein Kinases In The Regulation Of Plant Development, Erica Satterfield
The Role Of Mitogen-Activated Protein Kinases In The Regulation Of Plant Development, Erica Satterfield
Theses and Dissertations
Mitogen-activated protein kinases are part of an evolutionarily conserved protein phosphorylation cascade which serves essential regulatory functions in eukaryotic organisms. Although the role of MAPKs in the regulation of a plant’s response to environmental stress and plant defense has been well established, very little is known about their role in the regulation of plant developmental processes. In order to examine the role of MAPKs in plant growth and development, a strong mammalian MAPK phosphatase (MKP-1), which is known to inactivate MAPKs in plants, was introduced into tobacco plants. In tobacco plants, MKP-1 overexpression altered plant responses to the phytohormones, ethylene …
Cannabinoid Effects On Nfkappab Function In Microglial-Like Cells: Dual Mode Of Action, Latoya Griffin-Thomas
Cannabinoid Effects On Nfkappab Function In Microglial-Like Cells: Dual Mode Of Action, Latoya Griffin-Thomas
Theses and Dissertations
Cannabinoids have been shown to modulate the immune system in vitro and in animal models. A major area of interest is how cannabinoids impact the brain. A whole variety of neuropathies or brain disorders, such as AIDS dementia, Parkinson’s disease, Multiple Sclerosis and Alzheimer’s disease, are associated with a hyperinflammatory response within the brain. Microglia, the resident macrophages of the brain, are the major cell type responsible for the persistent elicitation of pro-inflammatory cytokines (IL-1a, IL-1b, IL-6, TNFa) and other mediators. In vitro experiments have demonstrated that the partial exogenous cannabinoid agonist delta-9-tetrahydrocannabinol (D9-THC) and the potent synthetic exogenous cannabinoid …
"Splintered And A Great Silence": The Production Of Return To The Upright Position By Caridad Svich, Catherine (Cate) Brewer
"Splintered And A Great Silence": The Production Of Return To The Upright Position By Caridad Svich, Catherine (Cate) Brewer
Theses and Dissertations
Like the Tribute in Light that grew phoenix-like from the ashes of the broken hearts of the artists who created it, Return to the Upright Position is a beautiful on-line collaboration amongst fourteen artists in the six months following 9/11. Conceived and edited by Caridad Svich, the play is moving and delicate and instantly brings us back to those moments when American history and sentiment were forever changed. Demoralized, terrorized, afraid, and alone, our country dragged its shocked and weary carcass from the ash, and pulled itself back up again. That is after all the American way, pulling yourself up …