Digital Commons Network^™

Disease Complexes: Complex Diseases, Larry A. Sagers

All Archived Publications

No abstract provided.

Determinants Of Adoption Of Security Systems To Address Bioterrorist Threats: An Analysis Of Dairy Farms In The Western United States, Nicolas K. Buttars, Allen J. Young, Deevon Bailey

Economic Research Institute Study Papers

Data generated from a survey of western dairy farms is used to determine the characteristics of dairy farmers who have undertaken to improve security measures on their farms during the past two or three years. The findings suggest that decisions to improve on-farm security are influenced by the producer's awareness of how to develop a security policy and also the size of the dairy operation. The results also support the notion that farms may be vulnerable to bioterrorist attacks because most farmers do not believe it is important to establish on-farm security policies.

Plant Disease Management, Larry A. Sagers

All Archived Publications

No abstract provided.

Methods For Detection Of Salmonella Spp., Parichaya Attaphongse

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Worldwide concern about food safety and associated health costs is increasing, and Salmonella contamination of foods is one of the most important causes of foodborne disease outbreaks. Although conventional detection methods for Salmonella offer high sensitivity and low cost, they require many different steps and are very time consuming. Ideally, methods to detect Salmonella in foods should be rapid, provide high specificity and sensitivity, be cost-effective, and low labor-intensive. Many rapid tests have been developed to address these goals, including DNA-based tests such as nucleic acid hybridization and PCR, immunoassay-based tests such as ELISA, ELF A and immunomagnetic method, and …

Parents' Knowledge And Attitudes About Immunization In India, Anne George

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Childhood immunization is acknowledged as being a crucial health intervention for children. Immunization rates of children may vary depending on their parents' knowledge and attitudes about the issue. The focus of this study is on parents' knowledge and attitudes about immunization, and employs Urie Bronfenbrenner's ecological systems theory. A questionnaire was administered to 233 parents in India to explore the issues of parental immunization knowledge and attitudes. Correlates of parental knowledge and attitudes that were explored included gender, education, respondents' immunization status, and children's immunization status. Sources of parental knowledge about immunization were also examined. Overall, parents in this sample …

Inhibition Of Severe Acute Respiratory Syndrome-Associated Coronavirus (Sarscov) By Calpain Inhibitors And Beta-D-N4-Hydroxycytidine, Dale L. Barnard, V. D. Hubbard, J. Burton, Donald F. Smee, John D. Morrey, M. Otto, R. W. Sidwell

Animal, Dairy, and Veterinary Science Faculty Publications

We evaluated two types of compounds for efficacy in inhibiting SARSCoV replication in vitro: calpain inhibitors (a class of cellular cysteine proteinases) and a number of nucleoside analogues. Cytopathic effect reduction assays visually determined with spectrophotometric verification by neutral red (NR) uptake assay were used to evaluate cytotoxicity and antiviral potency of the compounds. Significantly inhibitory compounds were then evaluated in virus yield reduction assays. Two calpain inhibitors, Val-Leu-CHO (calpain inhibitor VI) and Z-Val-Phe-Ala-CHO (calpain inhibitor III), were the most potent inhibitors of SARSCoV. By virus yield reduction assay, calpain inhibitor VI had a 90% effective concentration (EC90) of 3 …

Topical Cidofovir Is More Effective Than Is Parenteral Therapy For Treatment Of Progressive Vaccinia In Immunocompromised Mice, Donald F. Smee, K. W. Bailey, M-H. Wong, M. K. Wandersee, R. W. Sidwell

Animal, Dairy, and Veterinary Science Faculty Publications

Background.Severe complications may arise as a result of virus dissemination after smallpox (live vaccinia virus) vaccination, particularly in immunocompromised individuals. We developed a new mouse model for studying the effects of antiviral agents on progressive vaccinia virus infections.

Methods.Hairless mice were treated with cyclophosphamide (100 mg/kg/day) every 4 days starting 1 day before vaccinia virus exposure to wounded skin. Primary lesions progressed in severity, satellite lesions developed, and the infection eventually killed the mice.

Results.Topical treatment with 1%‐cidofovir cream (twice daily for 7 days) was much more effective in reducing the severity of primary lesions and the number of satellite …

Pesticide Applicator Training, Larry A. Sagers

All Archived Publications

No abstract provided.

Portion Distortion Plays A Major Role In The American Obesity Epidemic, Amanda Kay Larsen

Undergraduate Honors Capstone Projects

The prevalence of overweight and obesity among the American population is on the rise. This epidemic can be attributed to an increase in energy intake. Research has shown that increased consumption is associated with both individual and societal factors including an increase in the size of portions, the influence of the food industry, and confusion on the part of the consumer. The findings indicate that dietitians and other healthcare providers need to do their part by informing society of the importance of decreasing portions and helping the consumer recognize appropriate portion sizes.

Social Stratification And Health In Dynastic Egypt: The Differential Effect Of Disease Among The Elite And Working Classes, Jerilyn Hansen

Undergraduate Honors Capstone Projects

Social stratification in Dynastic Egypt between the elite and working class is suspected to have created differential health conditions for these two social classes. It is hypothesized that due to differing living conditions, resulting in varying levels of exposure to infectious pathogens, workloads, and quality of diet, the elite and working class will have dissimilar health conditions. Specifically, it is expected that the working class of Dynastic Egypt suffered ill health more often, and more severely, than the elite. The health conditions of the elite and working class were measured by the prevalence of the density-dependent disease tuberculosis, the workload-related …

Rapid Detection Of Listeria Monocytogenes, Wim Lippens

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Listeria monocytogenes is a foodbome pathogen that can cause severe illness and even death. It is found in dairy and meat products. The focus is on rapid detection since conventional methods are time consuming (4-5 days). Pre-enrichment steps, as part of those methods, are time consuming. Our objective was to develop a detection system without a pre-enrichment step, giving a final result within 2 to 4 h.

In the concept of "the need for speed," a detection system with an antibody-based capture technique, followed by polymerase chain reaction (PCR), was developed. Glass beads coated with a Listeria polyclonal antibody were …

Oral Rabies Vaccination: Reducing Economic Uncertainty Via Response Surface Analysis, Ray T. Sterner, Matthew M. Kling, Stephanie A. Shwiff, Dennis Slate

Wildlife Damage Management Conference

Economic uncertainty surrounds the distribution of Raboral V-RG7 as an oral rabies vaccine (ORV) bait for the containment or elimination of raccoon-variant rabies in the United States. This paper describes a costs-savings model of ORV. lt also describes Excel XP7 code that was prepared to compute potential net savings (NS) and benefit-cost ratios (BCRs) associated with Raboral V-RG7 bait distributions. Currently, baits and bait distributions are relatively expensive; individual baits are produced at a cost of $1.27 for federal use and typically dispensed at >75 baits/km2. Distribution is estimated at $8.62/km2, $15.80/km2, and $33.30/km2 for fixed-winged (FW), ground (Gnd), and …

Chronic Wasting Disease Of Cervids: Implications For Wildlife Management, Michael W. Miller, Elizabeth S. Williams

Wildlife Damage Management Conference

Chronic wasting disease (CWD) has recently emerged in North America as an important prion disease of captured and free-ranging cervids. This wildlife disease, endemic to southern Wyoming and northern Colorado, is the only recognized transmissible spongiform encephalopathy affecting free-ranging wildlife. We provide an overview of the research that has occurred on CWD over the past five years. The implications of CWD are not entirely clear at this time.

Oral Rabies Vaccination: Unresolved Issues And Data Gaps, Dennis Slate, Thomas Decker

Wildlife Damage Management Conference

Oral rabies vaccination (ORV) represents a potential wildlife management tool that may be applied to contain and perhaps eliminate specific rabies virus variants that persist in several terrestrial carnivore species in the U.S. Increasingly greater use of ORV in the U.S. since 1997 has sparked discussion within the wildlife profession regarding need, cost and effectiveness, as well as the potential for wildlife management and ecological impacts. We identify and present ORV-related issues and data gaps of concern to wildlife managers that should be addressed through research, rabies surveillance and population monitoring.

The Role Of Wildlife In Human And Animal Disease, John R. Fischer, Richard W. Gerhold

Wildlife Damage Management Conference

Strategies to assess and reduce risk associated with disease agents in wild animals must be based upon thorough knowledge of the epidemiology of the disease agent, specific local information, and other factors. Risk evaluation and management efforts will involve organizations with differing expertise and cooperation will be essential between wildlife management, public health, and domestic animal health agencies. Risk reduction strategies may be based upon manipulation of the disease agent, the host, the environment, and/or human activities. Management of human activity, particularly the promotion of biosecurity, may be the most efficient strategy because other measures are more difficult and expensive. …

Mycobacterial Diseases In Wildlife, Gary Witmer, Thomas Deliberto, Kurt Vercauteren, Peter Butchko

Wildlife Damage Management Conference

Mycobacterium infections occur in numerous wildlife species worldwide and this bacterial genus can also cause disease in humans and livestock. Two Mycobacterium species and one subspecies that infect wildlife are important from a wildlife damage management perspective. Mycobacterium avium, avian tuberculosis, is a ubiquitous and cosmopolitan disease of wild and domestic birds. Wild and domestic ruminants are host to M. avium paratuberculosis, also known as Johne's disease. Finally, Mycobaterium bovis, bovine tuberculosis, is primarily associated with domestic and wild bovines and ungulates, but also infects many other species of mammals. Eradicating these diseases from wildlife populations is very difficult if …

The Ecology Of New World Rodent Borne Hemorrhagic Fevers, Darin S. Carroll, Emily Jentes, James N. Mills

Wildlife Damage Management Conference

Few, if any, human settlements are free of peridomestic rodent populations. The threat of rodent borne zoonotic diseases has been widely recognized since the bubonic plague outbreaks of the Middle Ages. In the last decades, outbreaks of human disease caused by the rodent borne hemorrhagic fever viruses, the arenaviruses (family Arenaviridae), and the hantaviruses (family Bunyaviridae, genus Hantavirus) have again generated interest in the general public and scientific community regarding the biology of these types of diseases. Recent studies have identified more than 30 new members of these two groups of viruses. Most are associated with rodents in the family …

Feral Swine---Are They A Disease Threat To Livestock In The United States?, Gary W. Witmer, Robert B. Sanders, Arnold C. Taft

Wildlife Damage Management Conference

Feral swine populations provide both benefits and liabilities to citizens of the United States. Their expanding range and increasing densities, however, have raised concern over the adverse environmental and agricultural effects and the increased risk of disease transmission between feral swine and livestock. We discuss the role of feral swine in the transmission of wildlife diseases and, in particular, in diseases of national significance to the livestock industry. We also discuss available management tools and strategies for reducing feral swine populations, minimizing damage or disease occurrences and eradicating populations when deemed appropriate. Finally, we note areas of research that may …

The Emergence Of Major Avian Diseases In North America: West Nile Virus And More, Robert G. Mclean

Wildlife Damage Management Conference

Some major diseases of wild birds have emerged dramatically in North America recently due in part to the rapid global movement of animals and pathogens and major changes in the size, quality, and continuity of natural habitats. These diseases include invasive pathogens, emergence of new disease agents or syndromes, and reemergence of some established diseases. A prominent example is West Nile virus that invaded North America, became easily established, and has expanded throughout the continent within 4 years. A number of factors have influenced the frequency of occurrence, the variety of species affected, and the geographical extent of these emergent …

A Review Of Pathogens Of Agricultural And Human Health Interest Found In Canada Geese, Larry Clark

Wildlife Damage Management Conference

The roles that waterfowl in general, and Canada geese in particular, have in the dissemination and transmission of viral and bacterial diseases of human or agricultural importance are covered in this review. In addition to the biological information about the etiology of the disease, economic impacts and zoonotic potential of viral and bacterial pathogens are considered. In most cases existing evidence suggests the importance of waterfowl in disease dissemination and transmission, however, definitive data are often lacking, indicating the need for more directed studies before quantitative risk assessments can be made. Finally, a brief assessment of management options is considered.

Class I Integrons And Sxt Elements In El Tor Strains Isolated Before And After 1992 Vibrio Cholerae O139 Outbreak, Calcutta, India, Amita Kaundal, S. Roy Chowdhury, M. Thungapathra, Thandavarayan Ramamurthy, Gopinath Balakrish Nair, Amit Gosh

Plants, Soils, and Climate Faculty Publications

We examined the distribution of class I integrons and SXT elements in Vibrio cholerae O1 El Tor strains, isolated in Calcutta, India, before and after the V. cholerae O139 outbreak in 1992. Class I integrons, with aadA1 gene cassette, were detected primarily in the pre-O139 strains; the SXT element was found mainly in the post-O139 strains.

Ecological Implications Of Bovine Tuberculosis In African Buffalo Herds, A. Caron, P. C. Cross, Johan T. Du Toit

Wildland Resources Faculty Publications

Following the recent invasion of bovine tuberculosis (BTB) into the Kruger National Park, South Africa, we conducted a study on the maintenance host, African buffalo, to investigate associations between BTB prevalence and calf:cow ratio, age structure, body condition, and endoparasite load. Statistical analyses compared herds of zero, medium (1–40%), and high (>40%) BTB prevalence. To control for ecological variation across the park we collected data in northern, central, and southern regions and restricted some analyses to particular regions of the park. Body condition declined over the course of the 2001 dry season, and buffaloes in the southern region of …

All Tots Need Their Shots- Immunize By Two, Heidi Leblanc

All Archived Publications

This publication information about toddlers and shots and the recommended guidelines to follow.

Effects Of Myxobolus Cerebralis On The Population Dynamics Of Kokanee In Porcupine Reservoir, Utah, Arthur E. Butts

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study tracked the chronology and severity of Myxobolus cerebralis infection and related it to survival of age-0 kokanee to determine whether M. cerebralis represented a significant agent of morality in the population. Environmental conditions and losses to predation were identified and linked to age-0 kokanee survival to identify other sources of mortality in the population. We attempted to track survival of age-0 kokanee from the outmigration into the reservoir until the end of the first growing season in September of each year. The number of age-0 kokanee that entered the reservoir was calculated by obtaining estimates of total egg …

The Development Of A Bluetongue Virus Diagnostic Assay Using Peptides Derived From The Structural Protein Vp7 And Nonstructural Protein Ns2, Yi Lu

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Several peptides derived from viral proteins, VP7 and NS2 of bluetongue virus (BTV), were synthesized for an immunologic detection assay: distinguishing between bluetongue virus infected, vaccinated, and noninfected animals (ruminants) with dot blot analysis. The School of Veterinary Medicine, University of California, Davis, supplied the serum samples from 24 bovine, 18 caprine, 23 ovine. Another 205 bison serum samples were obtained in Utah. The serum samples of BTV-infected animals revealed detectable antibodies to both VP7 and NS2 peptides, whereas vaccinated animals only exhibited antibodies against VP7. Noninfected animals did not display antibody against either viral peptide. These data confirmed the …

How To Purchase A Healthy Home, Leona K. Hawks, Andria B. Hansen

All Archived Publications

No abstract provided.

Moisture & Bugs, Leona K. Hawks, Andria B. Hansen

All Archived Publications

No abstract provided.

Coumarins And Pyranocoumarins, Potential Novel Pharmacophores For Inhibition Ofmeasles Virus Replication, Dale L. Barnard, Z. Q. Xu, V. D. Stowell, H. Yuan, Donald F. Smee, R. Samy, R. W. Sidwell, M. K. Nielsen, L. Sun, H. Cao, A. Li, C. Quint, J. Deignan, J. Crabb, M. T. Flavin

Animal, Dairy, and Veterinary Science Faculty Publications

A series of coumarin and pyranocoumarin analogues were evaluated in vitro for antiviral efficacy against measles virus (MV), strain Chicago. Of the 22 compounds tested for inhibition, six were found to have selectivity indices greater than 10. These were compounds 5-hydroxy-7-propionyloxy- 4-propylcoumarin (2a), 5,7-bis(tosyloxy)-4- propylcoumarin (7); 5-hydroxy-4-propyl-7-tosyloxy- coumarin (8); 6,6-dimethyl-9-propionyloxy-4- propyl-2H,6H-benzo[1,2-b:3,4-b′]dipyran-2-one (9); 6,6-dimethyl-9-pivaloyloxy-4-propyl-2H,6Hbenzo[ 1,2-b:3,4-b′]dipyran-2-one (10); and 7,8-cis- 10,11,12-trans-4-propyl-6,6,10,11-tetramethyl- 7,8,9-trihydroxy-2H,6H,12H-benzo[1,2-b:3,4-b′:5,6- b′′]tripyran-2-one (18). Three of the active drugs were propyl coumarin analogues (2a, 7 and 8), two were dipyranone or chromeno-coumarins (9 and 10), and one was a benzotripyranone with a coumarin nucleus (18). Some appeared to be rather specific and potent …

Relationship Between Cag Repeats Of The N Terminal Region Of The Androgen Receptor And Body Shape, Michael John Wen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Androgen receptor (AR) gene CAG polymorphisms may be associated with body shape, and are associated with certain breast and prostate cancers. In addition, body shape is associated with risk for a variety of diseases, including heart disease, diabetes, and certain forms of cancer. The CAG repeat in exon l of the AR gene was quantified using Perkin Elmer Applied Biosystems GeneScan analysis software in 96 and 59 healthy Caucasian men and women, respectively, who were over the age of 50 years. All participants had body measurements taken and donated a blood sample. Waist measurements included circumferences at the 1) umbilicus …

Healing Logics, Erika Brady

All USU Press Publications

Scholars in folklore and anthropology are more directly involved in various aspects of medicine—such as medical education, clinical pastoral care, and negotiation of transcultural issues—than ever before. Old models of investigation that artificially isolated "folk medicine," "complementary and alternative medicine," and "biomedicine" as mutually exclusive have proven too limited in exploring the real-life complexities of health belief systems as they observably exist and are applied by contemporary Americans. Recent research strongly suggests that individuals construct their health belief systmes from diverse sources of authority, including community and ethnic tradition, education, spiritual beliefs, personal experience, the influence of popular media, and …