Digital Commons Network^™

Safety, Immunogenicity, And Efficacy Of A Recombinant Vesicular Stomatitis Virus Vectored Vaccine Against Severe Fever With Thrombocytopenia Syndrome Virus And Heartland Bandavirus, Philip Hicks, Tomaz B. Manzoni, Jonna B. Westover, Raegan J. Petch, Brianne Roper, Brian B. Gowen, Paul Bates

Animal, Dairy, and Veterinary Science Faculty Publications

Background: Severe fever with thrombocytopenia syndrome virus (STSV) is a recently emerged tickborne virus in east Asia with over 18,000 confirmed cases. With a high case fatality ratio, SFTSV has been designated a high priority pathogen by the WHO and the NIAID. Despite this, there are currently no approved therapies or vaccines to treat or prevent SFTS. Vesicular stomatitis virus (VSV) represents an FDA-approved vaccine platform that has been considered for numerous viruses due to its low sero-prevalence in humans, ease in genetic manipulation, and promiscuity in incorporating foreign glycoproteins into its virions. Methods: In this study, we developed a …

Maternal Adverse Childhood Experiences And Non-Live Births, Mudasir Mustafa

All Graduate Theses and Dissertations, Fall 2023 to Present

Around 62 percent of adults in the United States have endured at least one type of Adverse Childhood Experience (ACE), and 25 percent of women reported experiencing three or more ACEs in their lifetime. This study explored whether maternal exposure to ACEs was associated with pregnancy loss or abortion, utilizing the National Longitudinal Study of Adolescent to Adult Health (known as Add Health) to explore this association. I found that cumulative ACEs, assessed through either the conventional ACE scale (reflecting 10 types of ACEs) or the extended ACE scale (reflecting 14 types of ACEs), are associated with a higher likelihood …

Immune Variation Across Different Contexts In Non-Model Systems, Kwanho Claudia Ki

All Graduate Theses and Dissertations, Fall 2023 to Present

The immune system is important to an animal’s survival against disease-causing agents and physical injuries. Accordingly, many resources are required to maintain and activate the immune system (such as energy). However, as these resources also need to be shared with other important systems of the body, the portion of resources that can be allotted to the immune system is variable. Thus, many different factors may alter how well the immune system operates. My dissertation sought to understand what sorts of factors can lead to changes in the immune system. Reptiles are known to have a very robust immune system. Therefore, …

Designing Technology-Enriched Learning Environments: The Effects Of An Agent-Based Computer Model On Biology Students' Understanding Of The Covid-19 Pandemic And The Nature Of Models In Science, April Sullivan

All Graduate Theses and Dissertations, Fall 2023 to Present

Science education researchers have called for increased attention to the science practice of modeling to engage students in authentic scientific inquiry. A major challenge to integrating the modeling practice into science instruction is that students tend to conceptualize models as static end-products of research rather than generative tools for theory-building. Engaging students in using computer models, specifically agent-based computer models (ABMs), to explain and predict scientific phenomena could improve students' understanding of models in science. In this design-based research project I investigate the effects of an ABM-supported learning environment on high-school biology students' understanding of the COVID-19 pandemic and the …

Viking And Native North American Interactions: The Spread Of Disease In The Norse Discovery Of North America, Sarah N. Haughawout

Undergraduate Honors Capstone Projects

This paper evaluates the potential for spread of disease in the Norse and Native North American interactions around 1000 CE. At this time, the Vikings were expanding their territory in search of land and natural resources following the Viking Raids in mainland Europe. They traveled to Iceland, then Greenland, and finally the eastern coast of northern Canada. Norse explorers faced numerous obstacles on their journeys, but they still prospered in North America for a time. The Vikings hunted the land and sea mammals, used the land, and found ways to thrive while having hostile relations and contact with the Native …

Understanding Long Covid: Navigating The Journey To Recovery, Heather H. Kelley, Rachel Byers, Ty Aller, Timothy Keady

All Current Publications

This fact sheet provides very basic facts on what long COVID is and information on how to navigate the healthcare system and cope with long COVID.

Novel Hamster Models Of Chikungunya Viral Arthritis, Tian Wang, Zhongde Wang

Funded Research Records

No abstract provided.

Scale-Dependent Population Drivers Inform Avian Management In A Declining Saline Lake Ecosystem, Aimee M. Van Tatenhove, John Neill, Russell E. Norvell, Erica F. Stuber, Clark S. Rushing

Wildland Resources Faculty Publications

Shrinking saline lakes provide irreplaceable habitat for waterbird species globally. Disentangling the effects of wetland habitat loss from other drivers of waterbird population dynamics is critical for protecting these species in the face of unprecedented changes to saline lake ecosystems, ideally through decision-making frameworks that identify effective management options and their potential outcomes. Here, we develop a framework to assess the effects of hypothesized population drivers and identify potential future outcomes of plausible management scenarios on a saline lake-reliant waterbird species. We use 36 years of monitoring data to quantify the effects of environmental conditions on the population size of …

Sustainable Waste-To-Bioproducts Engineering Center Laboratory Safety Project, Claudine Mock

All Graduate Reports and Creative Projects, Fall 2023 to Present

Laboratory accidents are common in teaching and research labs; these accidents can be injurious or even fatal. The consequences of each type of laboratory accident are different based on the activities performed and the hazardous materials used in each facility. However, the most common issue related to laboratory accidents is the lack of proper safety measures (e.g., poor handling of hazardous materials, not reporting incidents immediately, etc.). This project aimed to establish and strengthen best practices and procedures to ensure laboratory safety at the Utah State University Sustainable Waste-to-Bioproducts Engineering Center. To achieve this goal, different practices and measures were …

Ecosystem Sentinels As Early-Warning Indicators In The Anthropocene, Elliott L. Hazen, Matthew S. Savoca, T.J. Clark-Wolf, Max Czapanskiy, Peter M. Rabinowitz, Briana Abrahms

Wildland Resources Faculty Publications

We are already experiencing the rapid pace of environmental perturbation in the Anthropocene, necessitating the development of new tools and techniques for measuring changes in ecosystem dynamics. Sentinel species, from birds to invertebrates, have been used to provide insights into ecosystem function, as leading indicators of risk to human health and as harbingers of future change, with implications for ecosystem structure and function. Here, we offer an update to previous research identifying marine top predators as indicators of ecosystem shifts and examine terrestrial sentinels and the latest research on sentinels of pollution and human health. Using ecosystem sentinels enables rapid …

Achieving Responsible Anomaly Detection, Xiao Han

All Graduate Theses and Dissertations, Fall 2023 to Present

In the digital transformation era, safeguarding online systems against anomalies – unusual patterns indicating potential threats or malfunctions – has become crucial. This dissertation embarks on enhancing the accuracy, explainability, and ethical integrity of anomaly detection systems. By integrating advanced machine learning techniques, it improves anomaly detection performance and incorporates fairness and explainability at its core.

The research tackles performance enhancement in anomaly detection by leveraging few-shot learning, demonstrating how systems can effectively identify anomalies with minimal training data. This approach overcomes data scarcity challenges. Reinforcement learning is employed to iteratively refine models, enhancing decision-making processes. Transfer learning enables the …

Spatiotemporal Dynamics Of Disease: Social And Environmental Drivers Of Movement, Connectivity, And Disease Transmission In Bighorn Sheep, Lauren E. Ricci

All Graduate Theses and Dissertations, Fall 2023 to Present

Movement is a fundamental component of animal ecology. Animals move in order to access resources and avoid risk. Movement decisions aggregated across time determine how individuals use space, contact dynamics between individuals within a population, and connectivity across a species range. These patterns that emerge from movement decisions have downstream implications for many ecological processes and a mechanistic understanding of movement can help answer broader questions about ecology.

Disease dynamics are intrinsically tied to movement. Understanding the mechanisms that drive movement can elucidate how disease will spread and impact host populations. In this vein, I employed a suite of movement …

Spatial Ecology Of Mule Deer Migrations From Grand Teton National Park And The Teton Range, Justin K. Schwabedissen

All Graduate Theses and Dissertations, Fall 2023 to Present

The Greater Yellowstone Ecosystem hosts several of the longest, fully intact ungulate migrations remaining in the continental United States. However, expanding development and an increasing human footprint continue to truncate migratory routes. While the endpoints are often a seasonal range on protected lands, these migration corridors frequently cross other jurisdictional boundaries, including large tracts of private or multiple-use lands, with varying levels of protection. Thus, it is critical resource managers understand the dynamics of migratory movements to define population-level corridors and prioritize appropriate conservation strategies. Mule deer in Wyoming have been documented traveling long distances between summer and winter ranges; …

Vectors And Vector Borne Disease: Models For The Spread Of Curly Top Disease And Culex Mosquito Abundance, Rachel M. (Frantz) Georges

All Graduate Theses and Dissertations, Fall 2023 to Present

Mathematical models are useful tools in managing infectious disease. When designed appropriately, these models can provide insight into disease incidence patterns and transmission rates. In this work, we present several models that provide information that is useful in monitoring diseases spread by insects.

In the first part of this dissertation, we present two models that predict disease incidence patterns for Curly Top disease (CT) in tomato crops. CT affects a wide variety of plants and is spread through the bite of the Beet Leafhopper. This disease is particularly devastating to tomato crops. When infected, tomato plants present with stunted growth …

Designing For Wellness: Enhancing First Responder Well-Being Through Fire Station Interior Architecture, Caimbre Bunton

Student Research Symposium

Firefighters face numerous health risks from physical and psychological stressors inherent in their profession. Occupational hazards include exposure to toxins, respiratory issues, cardiovascular and musculoskeletal diseases and heightened cancer risk. They are also at risk for mental health challenges like PTSD, anxiety, depression and sleep deprivation. Interior design interventions focusing on acoustics, thermal comfort, indoor air quality, health amenities, and containing and elimnating contaminants within the station are essential for mitigating these risks. These design strategies create a supportive and health focused environment for first responders so they can continue to support our communities. Station 45 is a model for …

Health Care Professionals’ Stigma Toward People With An Opioid Use Disorder: Preliminary Findings On The Effect Of Amount Of Contact Has On Stigma, Gabriela Murza, Cris Meier, Lily Ward, Sydney O'Shay, Rachel Myrer

Transforming Communities

Opioid-related deaths are the leading cause of injury deaths in Utah. Individuals who seek treatment for opioid misuse report stigma from healthcare professionals as the leading barrier to accessing treatment. Health professionals provide a variety of treatment options in efforts of combating high rates of opioid misuse. However, these professionals may not be properly trained in stigma reduction strategies, thus leading to poor client care and outcomes. The current study examined the association between contact with individuals who misuse opioids and stigma perceptions among healthcare professionals. A one-time survey was administered to healthcare professionals who practice in Utah using convenience …

The Utah Statesman, April 1, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Toolkit To Address Free-Ranging Domestic Cats On Agency Lands Managed For Native Wildlife And Ecosystem Health, Sara H. Schweitzer, Colin M. Gillin

Human–Wildlife Interactions Monographs

Native flora and fauna of North America face numerous threats, and impacts from invasive species are some of the most challenging. Free-ranging domestic cats (Felis catus) are extremely harmful to wildlife and the environment. The Association of Fish and Wildlife Agencies (AFWA) developed a toolkit to provide guidance to fish and wildlife agencies as they address free-ranging domestic cats on agency lands managed for native wildlife and ecosystem health. Topics in this document include wildlife conservation, infectious diseases, legal issues, education and outreach, human dimensions, partnerships, management strategies, and model regulatory and legal language. This toolkit is not …

New Associate Editors, S. Nicole Frey

Human–Wildlife Interactions

New associate editors include Neil Jordan and Allen Rutberg.

An Effective Method For Long-Term Control Of American Bullfrogs Syntopic With Special-Status Native Amphibians In California, Usa, Jeff A. Alvarez, Jeffery T. Wilcox

Human–Wildlife Interactions

American bullfrogs (Lithobates catesbeianus) are invasive in western North America and are well established in California, USA, where they are widespread. This invasive species has been implicated in the decrease of native amphibian populations and is believed to have contributed to the decline of threatened and endangered amphibians regionally. We utilized air rifles, tin alloy pellets, and 2 shooters to systematically control L. catesbeianus in both lentic and lotic habitat types within 2 counties in California. We visited sites monthly (April through November) for approximately 8 and 14 years to lethally target and remove L. catesbeianus …

Multi-Year Effectiveness Of Pzp-22 In Free-Roaming Suburban White-Tailed Deer, Allen T. Rutberg, Kali M. Pereira, Kayla A. Grams, John W. Turner Jr.

Human–Wildlife Interactions

To address the challenge that is posed to the use of fertility control to mitigate human–deer (Cervidae) conflicts by the need to regularly re-inoculate free-roaming animals, we captured, ear-tagged, and hand-injected 68 individual adult female white-tailed deer (Odocoileus virginianus) with the PZP-22 immunocontraceptive vaccine from February through April, 2014 to 2017, in the Village of Hastings-on-Hudson, New York, USA. Approximately 2.5 years after initial treatments, we booster-darted 29 of the previously treated females with either PZP-22 or native PZP (ZonaStat-D). We observed fawn production between 2014 and 2021. The combination of initial PZP-22 hand-treatments followed by single dart-delivered PZP …

The Challenge Of Hpai And The Role Of Human–Wildlife Interactions Research, S. Nicole Frey

Human–Wildlife Interactions

This is the letter from the editor-in-chief of Volume 18, Issue 3.

Monograph Available: Toolkit To Address Free-Ranging Domestic Cats On Agency Lands Managed For Native Wildlife And Ecosystem Health

Human–Wildlife Interactions

This is an announcement about the published monograph titled "Toolkit to Address Free-ranging Domestic Cats on Agency Lands Managed for Native Wildlife and Ecosystem Health." This publication, part of the HWI Monograph Series, is online and open access.

Analyzing The Impacts Of Beaver Dam And Beaver Dam Analog Complexes To Stream Ecology Within The Intermountain West, J. Marshall Wolf

All Graduate Theses and Dissertations, Fall 2023 to Present

Streams, rivers, and their floodplains throughout the world are impaired due to human modifications. Recent research has demonstrated that restoration projects prioritizing the proper functioning of ecosystems have better restoration outcomes than projects which focus on restoring form alone. Throughout North America, beaver-mediated restoration is becoming a leading method for improving the functioning of stream ecosystems that are in a degraded state. In areas where beaver are absent or the habitat is too degraded to currently permit their dam building, man-made beaver dam analogs (BDAs) are being used to restore stream habitat with an eye to future beaver recolonization. However, …

Characterization Of The Long-Distance Dispersal Kernel Of White-Tailed Deer And Evaluating Its Impact On Chronic Wasting Disease Spread In Wisconsin, Mennatallah Gouda

All Graduate Theses and Dissertations, Fall 2023 to Present

Chronic Wasting Disease (CWD) is a fatal, untreatable neurodegenerative disease that infects deer and related species. It is highly contagious and caused by abnormal malfunction and assembly of normal cellular proteins into aggregation-prone proteins. The Centers for Disease Control and prevention report that the prevalence of CWD in free-ranging deer in the US is still relatively low. However, in several states the infection rates exceed 1 deer in 10. Deer may uptake CWD from direct interaction with infected individuals or from the environment. Infected individuals shed CWD into the environment through feces, urine, saliva or carcasses, and long-distance dispersal of …

Ozgene: To Advance Humanity – Inspire Curiosity, Maarit Patrick, Mike Dixon

Huntsman School of Business Teaching Scholarship Series

The case introduces the students to Ozgene, an Australian firm that experienced a dramatic reduction in lead time of their products because of implementation of Lean principles. The case can be used in undergraduate or graduate courses in operations management or supply chain management as an introduction to Lean principles. The case also encourages students to consider the challenges that make-to-order differ from those of make-to-stock and explore production design principles.

Storing Eggs Safely, Christine Jensen, Charlotte P. Brennand

All Current Publications

Storing eggs safely is important for your health and that of your family. A method called "water glassing" for storing eggs was popular in the early 1900s, and some still continue using this method, but it is unsafe. This fact sheet addresses proper and safe ways to store eggs, including refrigeration, freezing, and freeze-drying.

Large, Wafer-Thin Optical Apertures Leveraging Photonic Integrated Circuits To Replace Telescopes For Communications, Cale M. Gentry, Marcus Bagnell, Shon Cook, Colby Bellew, Christopher Holland, Ify Achu, Aliyah Matthews, Navin Lingaraju, Lucas Cohen, Alessia Scotto Di Luzio, Nicole Heidel

Small Satellite Conference

To aid in driving down the size, weight, and power (SWaP) of space-based optical communications terminals, we present a large-aperture telescope-replacement technology that reshapes a beam from a single-mode fiber to ~5 cm and larger apertures on a silicon wafer by using photonic integrated circuit (PIC) components. We achieve multi-centimeter apertures by sacrificing wide-angle steering in favor of good beam quality and manageable controls. Light from a single-mode fiber is coupled to a silicon chip consisting of low-loss silicon nitride waveguides for signal distribution to large phase-controlled emitters. Our demonstrations of beam phasing across a 1.8-cm-diameter, 16-emitter phased array show …

Telehealth Acceptance And Commitment Therapy For Adolescents With Transdiagnostic Health-Related Anxiety: A Randomized Controlled Trial, Julie M. Petersen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Health-related anxiety is a growing issue to understand how to treat, particularly following the COVID-19 pandemic. Some studies show that a specific type of therapy, acceptance and commitment therapy (ACT), may be beneficial for health anxiety in adults, but this has not yet been tested with adolescents. The present study is a randomized, waitlist-controlled trial of ACT delivered via Zoom for adolescents struggling with health-related anxiety. A total of 30 adolescents (ages 12-17), plus one caretaker each (N = 60), living in Utah and currently struggling with health-related anxiety were enrolled. The majority of caretakers and adolescents were White, non- …

Exploring Versatile Glycosyltransferases From Microorganisms For Natural Product Biosynthesis, Jie Ren

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This dissertation is mainly focused on exploring versatile glycosyltransferases from different microorganisms with the purpose of biosynthesizing bioactive natural product glycosides through microbial fermentation. This engineered biosynthesis approach is environmentally friendly, safe, and efficient compared with plant extraction, chemical synthesis, and enzymatic synthesis. Additionally, we applied these characterized glycosyltransferases as efficient biocatalytic tools to produce novel glycosides to expand the chemical repertoire of nature. These novel compounds showed improved water solubility and some of them exhibited enhanced stability and biological activity, which laid the foundation for the development of new therapeutic agents.

In my dissertation research, I have discovered two …