Digital Commons Network^™

Development Of A Lethal Rodent Model Of Lymphocytic Choriomeningitis Virus Infection For Preclinical Antiviral Drug Testing, Rhett Fackrell

Student Research Symposium

Lymphocyctic Choriomeningitis virus (LCMV) is an Old World arenavirus belonging to the family Arenaviridae. The natural host is the common house mouse, with about 5% of the population persistently carrying and shedding the virus. LCMV is spread to humans through the aerosolized excrements of rodents or passed from mother to fetus through the placenta. Some of these cases lead to aseptic meningitis or meningoencephalitis with permanent neurological damage possible. Studies indicate that 2-5% of people are positive for serum LCMV antibodies [1]. LCMV infection has also occurred in organ transplant recipients, with nearly all cases being fatal [2]. There are …

Climate Change's Impacts May Necessitate Innovative Delivery Models In Us Healthcare Systems, Max Mauldin

Student Research Symposium

Medicaid is a federal programs within the US whose goal is to provide healthcare to vulnerable populations such as low-income adults, children, pregnant women, older adults and persons with disabilities. These groups are also some of the same groups found to be most at risk for vulnerability to and exposure to effects of climate change, such as “heat waves, extreme weather events, poor air quality, food safety, infectious diseases, and psychological stressors that can arise from these experiences. As climate change and its effects continue to worsen financial strain will be place on states’ Medicaid programs because of the exacerbating …

Translating -Omics Big Data: Comprehensive Understanding Of Host-Pathogen Interactions To Control Bacterial Blight In Alfalfa Using Computational Approaches, Raghav Kataria

Student Research Symposium

Plant infectious diseases are a major threat to the crops, owing to economic losses to the agriculture industry worldwide. Molecular interactions between the host and pathogen play a critical role in understanding the basis of pathogenesis. Majority of the Pseudomonas syringae strains are known to cause frost injury in plants, amongst which, P. syringae pv. syringae ALF3 is asserted to be a causal organism of bacterial stem blight in Medicago sativa (alfalfa). We elucidated the genome-scale host-pathogen interactions (HPIs) between alfalfa and P. syringae using two intense computational approaches: interolog (homology-based) and the domain-based method (based on 3D structure of …

Homelessness And Hygiene, Karen Goodsell

Student Research Symposium

Persons experiencing homelessness in the United States experience significant barriers to self-care and personal hygiene, including limited access to clean showers, laundry, toilets, and hand washing facilities. The obstacles to personal hygiene associated with homelessness may increase risk of infectious disease and has increasingly had effects on the homeless population due to the recent pandemic of COVID-19. Access to adequate sanitation, including toilets, showers, and hand-washing facilities is necessary for personal hygiene and good health. A vicious cycle can negatively impact homeless people without proper access to such facilities. Lack of personal hygiene and cleanliness can cause physical as well …

Illegal Wildlife Trade Increases Probability Of Zoonotic Disease Spread In The United States, Ryan Bushman

Student Research Symposium

Illegal wildlife trade is a major contributor to the spread of zoonotic disease in the United States and may potentially lead to further public health emergencies, a significant loss of life, and can cost billions of dollars. The trade of bushmeat and exotic pets are examples of illegal wildlife trade that can result in the spread of zoonotic diseases. These illegal activities are driven by deep-rooted cultural beliefs, financial necessity, and luxurious lifestyles. An analysis of the existing literature on these subjects through the lens of anticipatory intelligence reveals certain areas of the current systems that combat illegal wildlife trade …

Bolstering Southeast Asia's Livestock Biosecurity And Climate Change Resilience Essential For Global Health, Madelyn Kunzler

Student Research Symposium

A large factor of climate change is its effect on infectious zoonotic diseases. Zoonotic diseases are diseases that can be transferred from animals into humans. Cases of zoonotic diseases have increased as humans have interacted more with animals, and as worldwide travel has become more frequent. It is predicted that 60% of emerging human diseases will be zoonotic. The cases will continue to increase to due climate change. As climate change continues, research has shown that new diseases will emerge from the melting permafrost and ice caps. It is also likely that pre-existing diseases will be able to migrate to …

On An Imperative To Educate People On The History Of Race In America., Rachel Robinson-Greene

Languages, Philosophy, and Communication Studies Faculty Publications

2020 was a historic year for more than one reason. As a pandemic raged, in many areas unchecked in the United States, police brutality that caused the death of George Floyd brought to a boil racial strife that has been simmering in this country for many years. Black Lives Matter demonstrations across the globe motivated many to educate themselves, to improve their historical and cultural understanding of race in the United States. Others, most notably former President Trump, reacted quite differently. He exercised his power to implement a handful of policies on the topic of race, diversity, and inclusion. First, …

Post-Pandemic, Translational Research, And Indigenous Communities, Rodney C. Haring, Laticia Mcnaughton, Dean S. Seneca, Whitney Ann E. Henry, Donald Warne

Journal of Indigenous Research

It is well documented that American Indian/Alaska Native/Native Hawaiian/First Nations, known as Indigenous Peoples, have among the most significant health disparities in the world. Clinical services for these populations are typically underfunded, and Indigenous Peoples often have preexisting and co-occurring health conditions. These factors combined with a multitude of social inequities make Indigenous communities extremely susceptible to infectious diseases, including COVID- 19. This paper discusses perspectives on the post-pandemic frameworks and policies toward translational science as an approach to advance health promotion for community-based interventions, dissemination, and sustainability. The importance of exercising Indigenous self-determination, public health authority, and population health …

Data From: Recovery From Discrete Wound Severities In Side-Blotched Lizards (Uta Stansburiana): Implications For Energy Budget, Locomotor Performance, And Oxidative Stress, Susannah S. French, Spencer B. Hudson

Browse all Datasets

Wounding events (predation attempts, competitive combat) result in injuries and/or infections that induce integrated immune responses for the recovery process. Despite the survival benefits of immunity in this context, the costs incurred may require investment to be diverted from traits contributing to immediate and/or future survival, such as locomotor performance and oxidative status. Yet, whether trait constraints manifest likely depends on wound severity and the implications for energy budget. For this study, food intake, body mass, sprint speed, and oxidative indices (reactive oxygen metabolites, antioxidant capacity) were monitored in male side-blotched lizards (Uta stansburiana) healing from cutaneous wounds of discrete …

Data For "Arch_Covid_Crowding_Vc", Wayne Freimund, Zachary D. Miller

Browse all Datasets

Monitoring of visitor use in Arches National Park to assess social distancing behaviors of visitors during the COVID-19 pandemic.

Community Paramedicine: A New Approach To Health In Rural Communities, Kira Swensen, Timothy Keady, Ashley Yaugher, Kandice Atisme, Emma Parkhurst, Hailey Judd, Maren Wright Voss

All Current Publications

The community paramedicine (CP) concept is becoming widely used in rural communities to assist in maintaining and improving health across economic and geographic disparities. This model utilizes highly trained emergency medical service (EMS) professionals under the supervision of a physician or other advanced practice practitioner (i.e., physician assistants and advanced practice registered nurses; Patterson et al., 2016) to provide a variety of needed health services tailored to community needs. CP has been shown to be effective in many communities and, given these positive results, should be considered in rural communities where geographic barriers limit access to healthcare (Martin & O'Meara, …

Coupled Ecological And Management Connectivity Across Administrative Boundaries In Undeveloped Landscapes, Clare E. Aslan, Mark W. Brunson, Benjamin A. Sikes, Rebecca S. Epanchin-Niell, Samuel Veloz, David M. Theobald, Brett G. Dickson

Environment and Society Faculty Publications

Human-induced ecological boundaries, or anthropogenic ecotones, may arise where administrative boundaries meet on undeveloped lands. Landscape-level ecological processes related to factors such as fire, invasive species, grazing, resource extraction, wildlife, and water may be affected due to unique management strategies adopted by each administrative unit. Over time, different management can result in discernible ecological differences (e.g., species composition or soil characteristics). Thus, fragmentation in the management landscape can correspond to ecological fragmentation. Different ecological patterns may emerge due to an increase in the number of management units in a region, or due to an increase in the number of different …

Utah State Magazine, Winter 2021, Utah State University

Utah State Magazine

The quarterly magazine for friends and alumni of Utah State University.

Covid-19: The Spearpoint Of Human–Wildlife Interactions, Terry A. Messmer

Human–Wildlife Interactions

This is the letter from the editor-in-chief.

Uvc Automatic Door Handle Sanitizer, Dean Dalton, Tate Patterson

Electrical and Computer Engineering

Infectious disease is easily spread through the use of door handles

• A virus placed on a single door handle can spread through the remainder of the building within 2 to 4 hours
• Ultraviolet Class C light (UVC) is effective at sanitizing surfaces easily and at a low cost
• UVC light can be harmful when there are high levels of direct exposure to the eyes

Automatic Door Handle Sanitizer

• The device applies UVC light to effectively sanitize while safely allowing the use of the door

Utah State Engineer, Fall 2020, College Of Engineering

College of Engineering Magazines

Annual magazine for the College of Engineering at Utah State University.

Nato And The Ifrc: A Comparative Case Study, Abigail Kosiak

Undergraduate Honors Capstone Projects

This research analyzes the North Atlantic Treaty Organization's (NATO) Multinational Telemedicine System (MnTS) Project and works to answer five main questions:

1) What challenges did the NATO MnTS Project face that are directly related to the fact that the project included members from different countries and worked to create a system that operates across national borders?

2) How do these challenges compare to those faced by a non-governmental organization (NGO) like the International Federation of the Red Cross and Red Crescent Societies (IFRC)?

3) What successes has the IFRC had with its current operational model?

4) In what ways could …

Be Students Engage With Industry Leaders At Virtual Conference, Usu College Of Engineering

College of Engineering News

Nov. 9, 2020 — The Biological Engineering Department hosted its third annual Intermountain Biological Conference on Oct. 30 and 31. This year’s theme was Biological Engineering’s Impact on Public Health. Featured speakers came from industry partners and government agencies. The event was held virtually due to COVID-19 restrictions. For the poster session, students were required to submit a video explaining their research along with a digital poster.

Pathway To Amplification In Children Who Passed Their Universal Newborn Hearing Screening Bilaterally, Derek J. Stiles, Kathryn Broughton, Jane Rose, Emily Trittschuh

Journal of Early Hearing Detection and Intervention

Purpose: The aim of this study was to investigate the pathway to amplification technologies for children who passed their universal newborn hearing screening (UNHS) bilaterally with the intent of revealing effective strategies to identify children with acquired or progressive hearing losses. Additionally, the degrees, types, and causes of hearing loss, as well as the types of amplification used by the patients were investigated. Methodology: Medical records were reviewed for 102 children who passed their UNHS bilaterally and who are enrolled in the Boston Children’s Hospital Amplification or Cochlear Implant Programs. Of the 204 total ears, 177 ears were identified with …

South Dakota Parents’ Knowledge Of Congenital Cytomegalovirus, Its Long-Term Health Effects, And Methods For Minimizing Exposure, Felicia Reimann, Jessica Messersmith, Hannah Williams, Emily Riley

Journal of Early Hearing Detection and Intervention

Congenital CMV (cCMV) is acknowledged as one of the most common causes of nonhereditary sensorineural hearing loss and an important cause of neurodevelopmental delay in children. Despite the danger cCMV poses, many parents are unaware of the virus, its sequelae, mode of transmission, and preventative behaviors. The purpose of the study was to determine South Dakota parents’ knowledge of cCMV, its sequelae, and ways to minimize exposure.

An electronic survey was utilized for data collection. Parents of children born in South Dakota from 2011 to 2018 were asked about their knowledge of CMV and cCMV, including common sequelae and ways …

Journal Of Early Hearing Detection And Intervention: Volume 5 Issue 2, Pages 1-84

Journal of Early Hearing Detection and Intervention

No abstract provided.

Bear River Health Department: Covid-19 Contact Tracing, Mike Dixon, Zach Rusk

Huntsman School of Business Teaching Scholarship Series

This case introduces students to a highly variable process that has uncertain demand and processing times. It describes the contact tracing efforts as a response to positive Covid-19 cases in a rural health district in the state of Utah during the first 9 months of the pandemic of 2020. The case puts students in the shoes of the managing director of a health department trying to decide how to best manage a team of contact tracers who are increasingly unable to timely complete their work that is vital to stopping the spread of the disease.

Definition And Characteristics Of Behavioral Medicine, And Main Tasks And Goals Of The International Society Of Behavioral Medicine –An International Delphi Study, Joost Dekker, Marie Amitami, Anne H. Berman, Helen Brown, Bryan Cleal, Maria João Figueiras, Lila J. Finney Rutten, Egil A. Fors, Konstadina Griva, Jing Gu, Chris Keyworth, Maria Kleinstäuber, Claas Lahmann, Joseph T. F. Lau, Bernd Leplow

Psychology Faculty Publications

Background: In the past decades, behavioral medicine has attained global recognition. Due to its global reach, a critical need has emerged to consider whether the original definition of behavioral medicine is still valid, comprehensive, and inclusive, and to reconsider the main tasks and goals of the International Society of Behavioral Medicine (ISBM), as the umbrella organization in the field. The purpose of the present study was to (i) update the definition and scope of behavioral medicine and its defining characteristics; and (ii) develop a proposal on ISBM’s main tasks and goals. Method: Our study used the Delphi method. A core …

The Utah Statesman, September 8, 2020, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Memantine Treatment Reduces The Incidence Of Flaccid Paralysis In A Zika Virus Mouse Model Of Temporary Paralysis With Similarities To Guillain-Barré Syndrome, Venkatraman Siddharthan, Hong Wang, Alexandre Lr De Oliveria, Xin Dai, John D. Morrey

Animal, Dairy, and Veterinary Science Faculty Publications

Clinical evidence suggests that Zika virus contributes to Guillain-Barré syndrome that causes temporary paralysis. We utilized a recently described Zika virus mouse model of temporary flaccid paralysis to address the hypothesis that treatment with an N-methyl-D-aspartate receptor antagonist, memantine, can reduce the incidence of paralysis. Aged interferon alpha/beta-receptor knockout mice were used because of their sublethal susceptibility to Zika virus infection. Fifteen to twenty-five percent of mice infected with a Puerto Rico strain of Zika virus develop acute flaccid paralysis beginning at days 8–9 and peaked at days 10–12. Mice recover from paralysis within a week of onset. In …

New World Mammarenaviral Hemorrhagic Fever Virus Determinants Of Infection And Disease, Brady T. Hickerson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Several New World mammarenaviruses (NWM) are able to cause life-threatening hemorrhagic disease in humans. These agents use human transferrin receptor 1 (hTfR1), the main protein involved in cellular uptake of iron, to infect cells. Furthermore, use of hTfR1 correlates with the ability of these viruses to cause severe disease in humans. The most prevalent pathogenic NWM is Jun√≠n virus (JUNV), which is the etiological agent of Argentine hemorrhagic fever (AHF).The pathogenesis of AHF is poorly understood. A cardinal feature of severe cases of AHF is a prolonged increase of serum interferon-a (IFN-a) concentration. This increase is hypothesized to play a …

Cytomegalovirus Inhibition By Pluronic-Encapsulated Quercetin And Synergy With Ganciclovir, Ian Wadsworth

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Congenital cytomegalovirus (CMV) is the leading viral cause of birth defects worldwide and leads to a variety of complications. Ganciclovir is the most common anti-CMV drug used but often causes severe side effects. Quercetin, a plant pigment, shows anti-CMV activity that may provide a less toxic alternative to ganciclovir, or when co-administered, reduce ganciclovir treatments. However, a drug carrier is needed to deliver quercetin for CMV treatment. In this study, three Pluronic polymers (P123, F127, and F68) were investigated as a quercetin drug delivery system (DDS) for CMV treatment.

All selected Pluronics successfully encapsulated quercetin at varying degrees of efficacy. …

Supporting Adolescent Mental Health Within School Culture And Curricula: Inviting Adolescents To Utah's Mental Health Conversation, Diana West

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Utah is facing a mental health crisis. Between 2011 and 2017, teen suicides nearly tripled in Utah and had become the leading cause of death for children ages 10-17. Educators and policymakers are scrambling to provide students with mental health supports in schools, but an incomplete understanding of the challenges that students face can make it difficult to meet their needs. Each year state agencies ratchet up awareness, funding, and the determination to support mental health initiatives, but each year adolescent mental health in Utah becomes more precarious. The purpose of this study is to change the conversation by inviting …

Characterization Of A Novel Stat 2 Knock Out Hamster Model Of Crimean Congo Hemorrhagic Fever Virus Pathogenesis, Charlene Ranadheera, Emelissa J. Valcourt, Bryce M. Warner, Guillaume Poliquin, Kyle Rosenke, Kathy Frost, Kevin Tierney, Greg Saturday, Jinxin Miao, Jonna B. Westover, Brian B. Gowen, Stephanie Booth, Heinz Feldmann, Zhongde Wang, David Safronetz

Animal, Dairy, and Veterinary Science Faculty Publications

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen causing a febrile illness in humans, which can progress to hemorrhagic manifestations, multi-organ failure, and death. Current mouse models of CCHFV infection reliably succumb to virus challenge but vary in their ability to reflect signs of disease similar to humans. In this study, we established a signal transducer and activator of transcription 2 (STAT2) knockout hamster model to expand the repertoire of animal models of CCHFV pathogenesis that can be used for therapeutic development. These hamsters demonstrated a systemic and lethal disease in response to infection. Hallmarks of human …

Information Search And Financial Markets Under Covid-19, Behzod B. Ahundjanov, Sherzod Akhundjanov, Botir B. Okhunjanov

Applied Economics Faculty Publications

The discovery and sudden spread of the novel coronavirus (COVID-19) exposed individuals to a great uncertainty about the potential health and economic ramifications of the virus, which triggered a surge in demand for information about COVID-19. To understand financial market implications of individuals’ behavior upon such uncertainty, we explore the relationship between Google search queries related to COVID-19—information search that reflects one’s level of concern or risk perception—and the performance of major financial indices. The empirical analysis based on the Bayesian inference of a structural vector autoregressive model shows that one unit increase in the popularity of COVID-19-related global search …