Digital Commons Network^™

Lentiviral Vector Production At High Cell Density By Transient Transfection Of Suspended Culture Hek Cells, Jacob G. Accordino

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Viral vectors are gene carriers that efficiently deliver therapeutic gene constructs to target cells. Viral vectors are frequently produced in suspension-growing cells of mammalian origin, referred to as packaging cells. Lentiviral vectors have become widely used as gene vectors since they were initially developed two and a half decades ago, particularly in research settings. The advantages of lentiviral vectors for treating diseases of genetic origin have driven research into their large-scale manufacture for clinical settings. Currently, three main challenges exist that limit mass production of lentiviral vectors. First, plasmid DNA used in the production process is very expensive. Second, high …

Pesticide-Leaf Interactions And Their Implications For Pesticide Fate Modeling, Ashlie Kinross

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The work described here provides measured data to improve the understanding of the interaction between a pesticide and leaf surface after application. Two methods were developed, one using a newly introduced instrument, for the extraction of pesticides from leaves. This is required to measure the concentration of pesticide in the leaves. Using one of the developed extraction methods, measurements were made to determine how a pesticide equilibrates between a leaf and the air above it. These measurements were incorporated into a pesticide fate model that predicts how a pesticide moves through the environment after application to an agricultural field. The …

An Exploration Of System Level Dimensions Of Nutrition In Relation To Health: Interprofessional Teams And Food Insecurity, Mckenna Christy Voorhees

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Many factors influence health; two such factors that warrant additional research include interdisciplinary healthcare teams and food insecurity. These factors may be particularly important among vulnerable populations such as individuals with special healthcare needs, lower income populations, and individuals with disabilities.

Interdisciplinary teamwork promotes improved, and more efficient patient care through the collaboration of healthcare providers in various professional disciplines. Registered Dietitian Nutritionists (RDNs) are experts in the science and application of nutrition, which plays an important role in various disease states. Despite the established need for RDNs on interdisciplinary teams, there is limited research in the interdisciplinary scholarship targeting …

Conservation Genetics Of A Declining Bumble Bee In Western North America; The Influence Of Geography, Dispersal Limitation, And Anthopogenic Activity, Ashley T. Rohde

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Conservation biology addresses the problem of species loss by identifying species in need of protection. Conservation biology has subfields to address different aspects of biodiversity loss, including genetics and sociology. I used genetic approaches to assess the conservation status of western bumble bees, a bumble bee species of conservation concern.

The western bumble bee is a bumble bee species that ranges from Alaska to New Mexico and as far east as Wyoming and Colorado. This species is disappearing in some places. It may soon be listed as endangered in the United States and is already listed as endangered in parts …

Geometry- And Accuracy-Preserving Random Forest Proximities With Applications, Jake S. Rhodes

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Many machine learning algorithms use calculated distances or similarities between data observations to make predictions, cluster similar data, visualize patterns, or generally explore the data. Most distances or similarity measures do not incorporate known data labels and are thus considered unsupervised. Supervised methods for measuring distance exist which incorporate data labels and thereby exaggerate separation between data points of different classes. This approach tends to distort the natural structure of the data. Instead of following similar approaches, we leverage a popular algorithm used for making data-driven predictions, known as random forests, to naturally incorporate data labels into similarity measures known …

The Status Of Women Leaders In Utah Public Education (K–12): A 2022 Update, Hannah Payne, Kim Buesser, Susan R. Madsen

Marketing and Strategy Faculty Publications

In 2014, the Utah Women & Leadership Project (UWLP) released a research and policy brief titled “The Status of Women Leaders in Utah Education,”¹ and an updated version was published in 2017.² The reports focused on the status of women’s leadership in all Utah education sectors. In 2021, UWLP updated the postsecondary education portion of the brief,³ and this report provides an update of the K–12 portion. The purpose of this brief is to determine what, if any, progress has been made in women’s leadership within Utah’s K–12 education sector, including public and charter schools. This brief …

Blood Chemistry And Biliverdin Differ According To Reproduction And Tourism In A Free-Living Lizard, Susannah French

Browse all Datasets

Changes in the physiological health of species are an essential indicator of changing conditions and environmental challenges. Reponses to environmental challenges can often induce stress, influence physiology, and change metabolism in organisms. Here we tested blood chemistry parameters indicative of stress and metabolic activity using an i-STAT point-of-care blood analyzer in seven populations of free-ranging rock iguanas exposed to varying levels of tourism and supplemental feeding. We found significant differences in blood chemistry (glucose, oxygen, carbon dioxide, hematocrit, hemoglobin, calcium, potassium, and biliverdin levels) among populations exposed to varying levels of tourism, and also some variation between sexes and reproductive …

Data From: Complex Tourism And Season Interactions Contribute To Disparate Physiologies In An Endangered Rock Iguana, Susannah French

Browse all Datasets

To promote survival and fitness, organisms use a suite of physiological systems to respond to both predictable and unpredictable changes in the environment. These physiological responses are also influenced by changes in life history state. The continued activation of physiological systems stemming from persistent environmental perturbations enable animals to cope with these challenges but may over time lead to significant effects on the health of wildlife. In the present study, we tested how varying environmental perturbations driven by tourism and associated supplemental feeding affects the energetics, corticosterone and immunity of six discrete populations of the northern Bahamian rock iguana (Cyclura …

Managing Stress For Agricultural Producers: Learning To "Unhook", Jacob Gossner, Beth Fauth, Tasha Howard

All Current Publications

All of us experience stress, and with it, unpleasant, uncomfortable, or distressing thoughts. Agriculture can be an especially stressful profession. Much of the time, people are able to manage the stress—we refocus on our lives and move on. At other times, however, stressful thoughts impact moods negatively. These thoughts seem to consume all attention, pulling people away from others and things they care about in a process called “getting hooked” (Harris, 2019). Unhelpful thoughts may make people act in ways they don’t feel good about. The good news is that people can learn skills to “unhook” from unhelpful thoughts and …

Utah Brand Inspections For Horses, Karl Hoopes, Jacob Hadfield, Jessie Hadfield

All Current Publications

Brand inspection laws and proof of ownership laws are often misunderstood by horse owners in Utah. Outlined in this paper are the current laws regarding requirements for proof of ownership while traveling and brand inspection requirements during the transfer of ownership.

Does Internalized Stigma Change The Way That Religiousness Relates To Depression For People With Minoritized Sexualities?, G. Tyler Lefevor, Chana Etengoff, Samuel J. Skidmore

Psychology Faculty Publications

Drawing on minority stress and intersectionality theories, we examine whether the relationship between religiousness and depression among people with marginalized sexualities changes as a function of their experience of internalized stigma. Analyses of a sample of 260 people with marginalized sexualities suggested that the relationship between religiousness and depression was moderated by internalized homonegativity. Simple slopes analyses revealed that when people with marginalized sexualities reported higher degrees of internalized homonegativity, the relationship between religiousness and depression was positive. Conversely, when people with marginalized sexualities reported lower degrees of internalized homonegativity, religiousness was negatively related to depression. Dismantling analyses using subscales …

Oaks In The Landscape, Sheriden M. Hansen, Jaydee Gunnell, Andra Emmertson

All Current Publications

Oak trees (Quercus sp.) are generally a tough, drought tolerant, and beautiful addition to Utah landscapes. There are roughly 450 known species of oak, with about 60 cultivars that are native to North America. Oaks are known for slow growth, sturdiness, and easy care and can be used to create a focal point and ornamental interest in the landscape. This fact sheet reviews recommended cultivars for the Intermountain West and how to grow them, including site selection and preparation, planting and spacing, irrigation, and addressing challenges such as weeds, fertilization, pruning, and diseases and pests.

Leveraging Personal Values In An Endocrine Therapy Adherence-Promoting Trial For Breast Cancer Survivors: A Mixed-Methods Investigation, Joanna J. Arch, Elizabeth Slivjak, Emma E. Bright, Catherine M. Crespi, Michael E. Levin, Sarah R. Genung, Madeline Nealis, Karen Albright, Jill L. Mitchell, Ami D. Sheth, Jessica F. Magidson, Annette L. Stanton

Psychology Faculty Publications

Background: Improving medication adherence represents one of the greatest behavioral challenges in medicine. Personal values are an under-examined source of motivation for adhering to medication. This secondary analysis leverages a mixed-method approach to understanding a novel, online, values-based intervention (‘REACH’) for promoting endocrine therapy (ET) adherence among breast cancer survivors, using data from a randomized trial.

Methods: Breast cancer survivors with challenges taking ET (n=88) were randomized 1:1 to ET Education + Values (REACH) or Education-only online interventions. This report focuses on the three values strategies used in REACH to promote ET adherence: affirming health-related values, using values-based …

The Status Of Utah American Indian Women, Tasha Toy, Marin Christensen, Susan R. Madsen

Marketing and Strategy Faculty Publications

In 2021, the Kem C. Gardner Policy Institute reported that “Utah ranks as the 34th most racially and ethnically diverse state in the nation, with 22% of the state identifying as other than non-Hispanic White.”¹ As the state continues to become more diverse, it is critical that the Utah Women & Leadership Project (UWLP) conducts and reports research focused on women of color. As the UWLP focuses on strengthening the impact of all Utah girls and women, research that increases our understanding of the status and experiences of girls and women within all social and identity groups—including race and …

Helping Utah Landowners Reduce Pesticide Use Through A Statewide Ipm Program, Nick Volesky, Mair Murray

Outcomes and Impact Quarterly

The Utah Integrated Pest Management (IPM) program provides outreach and education to Utahns to reduce pesticide use and ultimately protect human and environmental health. In 2022, the IPM program responded to stakeholders’ needs by partnering with county Extension offices to deliver eight (8) in-person workshops across the state. The workshops connected Extension specialists and county faculty with managers of home landscapes and farms. The objective of the workshops was to provide participants with IPM skills to identify, monitor, and manage pest problems in preparation for the upcoming growing season.

Longitudinal Impacts Of Pandemic-Induced Disruptions On Adolescent Siblings' And Parents' Alcohol Use: A Family Life Course Perspective, Shawn D. Whiteman

Funded Research Records

No abstract provided.

Fatherhood Education During The Pandemic, Joshua J. Turner, Brian J. Higginbotham, Kay Bradford

Outcomes and Impact Quarterly

This article highlights the transition of Healthy Relationships Utah from in-person to virtual fatherhood education workshops during the COVID-19 pandemic. Overall, evaluation results showed no differences in program outcomes between in-person and virtual formats. Qualitative data from virtual participants illustrates the benefits and challenges of virtual program delivery.

Trauma Exposure And Trauma Symptoms As Predictors Of Police Perceptions In Latinx Youths, Amanda Venta, Germán Cadenas, Alfonso Mercado, Luz M. Garcini, Melanie M. Domenech Rodríguez

Psychology Faculty Publications

Objective: The Latinx immigrant youth population composes nearly a quarter of all children in the U.S. and are a high-risk group for police encounters. Based on perceptions of Latinxs as criminals, increased enforcement actions against Latinxs in the U.S., and failures of policing and police brutality in immigrants’ home countries, we expected that immigrants who reported increased trauma exposure and symptoms would have more negative perceptions of police. Method: This study utilized data from 107 recently immigrated Latinx youth to examine how trauma exposure (Child Trauma Screen) and symptoms (Child PTSD Symptoms Scale) related to perceptions of police (Criminal Sentiments …

Bioelectrical Impedance Changes Of The Trunk Are Opposite The Limbs Following Acute Hydration Change, Dale R. Wagner

Kinesiology and Health Science Faculty Publications

This study aimed to evaluate the changes in impedance and estimates of body composition variables obtained from segmental multi-frequency bioelectrical impedance analysis (SMFBIA) following acute hydration change. All participants (N = 11 active adults) had SMFBIA measurements at baseline (euhydration), post-dehydration, and post-hyperhydration in an experimental repeated-measures design. Dehydration and hyperhydration trials were randomized with the opposite treatment given 24 h later. Dehydration was achieved via a heat chamber of 40 °C and 60% relative humidity. Hyperhydration was achieved by drinking lightly-salted water (30 mmol·L^-1 NaCl; 1.76 g NaCl·L^-1) within 30 min. Post-measurements were taken 30 min …

Infusing Indigenous Knowledge Systems (Iks) Into Teaching Integrated Stem Disciplines: An Empirical Project, Iman C. Chahine

Journal of Indigenous Research

More recently, archaeological evidence collected from different cultures has unearthed numerous indigenous technologies that inherently embody specific scientific and mathematical structures, such as number systems, folk games and puzzles, kinship relations, divination systems, and symmetric strip architecture (Chahine, 2011). Building on the ingenuity of numerous indigenous cultures, such as Southeast Asian and African cultures, research has provided some opportunities to various uses of materials, which represent invaluable clues to cultural connections and continuities through space and time. While ample evidence in the literature supports the assertion that culturally relevant pedagogy can provide meaningful context for learning, there is shortage in …

Space Bioprocess Engineering On The Horizon, Aaron J. Berliner, Isaac Lipsky, Davian Ho, Jacob M. Hilzinger, Gretchen Vengerova, Georgios Makrygiorgos, Matthew J. Mcnulty, Kevin Yates, Nils J. H. Averesch, Charles S. Cockell, Tyler Wallentine, Lance C. Seefeldt, Craig S. Criddle, Somen Nandi, Karen A. Mcdonald, Amor A. Menezes, Ali Mesbah, Adam P. Arkin

Chemistry and Biochemistry Faculty Publications

Space bioprocess engineering (SBE) is an emerging multi-disciplinary field to design, realize, and manage biologically-driven technologies specifically with the goal of supporting life on long term space missions. SBE considers synthetic biology and bioprocess engineering under the extreme constraints of the conditions of space. A coherent strategy for the long term development of this field is lacking. In this Perspective, we describe the need for an expanded mandate to explore biotechnological needs of the future missions. We then identify several key parameters—metrics, deployment, and training—which together form a pathway towards the successful development and implementation of SBE technologies of the …

Sexual Complexity: A Comparison Between Men And Women In A Sexual Minority Sample Of Members Of The Church Of Jesus Christ Of Latter-Day Saints, William S. Bradshaw, John P. Dehlin, Renee V. Galliher

Psychology Faculty Publications

We report here some of the results from an online survey of 1612 LGBTQ members and former members of the Church of Jesus Christ of Latter-day Saints (CJCLDS, Mormon). The data permitted an exploration of diversity—individual similarities and differences within and between the sexes. Men and women were compared with respect to sexual identity self-labeling and behavior (i.e., identity development, disclosure, activity), orientation change efforts, marital relationships, and psychosocial health—these variables in the context of their religious lives. More women than men self-identified in the bisexual range of the sexual attraction continuum. Both men and women had engaged in extensive …

The Status Of Utah Hispanic Or Latina Women, Jessica C. Hill, Marin Christensen, Susan R. Madsen

Marketing and Strategy Faculty Publications

In 2021, the Kem C. Gardner Policy Institute published a databook on race, ethnicity, and sex, and since that time related dialogues have become more common. According to these data, Utah is becoming increasingly diverse, which has brought wide disparities between most minority groups and the White population in terms of education, housing, and health outcomes.¹ To continue this important conversation, the Utah Women & Leadership Project (UWLP) is expanding and deepening this research by publishing a series of research snapshots on Utah women of color. Often, research entities publish data on gender and race separately, leaving a gap …

Intermediate Help With Using Digital Devices And Online Accounts: Understanding The Needs, Expectations, And Vulnerabilities Of Young Adults, Hanieh Atashpanjeh, Arezou Behfar, Cassity Haverkamp, Maryellen Mcclain Verdoes, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

With the revolution in digital technologies, users face challenges to learn, understand, and use modern devices and online services. Thus, they seek intermediate help, i.e., assistance from others to avail the benefits of technological advancement. The prior studies showed that people with special needs, including the users with visual impairments, and older adults ask for help from their caregivers as they encounter problems with technology use. However, there is a gap in existing literature to systematically investigate the expectations, and challenges of users in availing help from others with using digital devices (e.g., computers, mobile phones) and online accounts. We …

Evidence For Multiple Potential Drivers Of Increased Phosphorus In High-Elevation Lakes, J. Scholz, Janice Brahney

Watershed Sciences Faculty Publications

Total phosphorus (TP) concentrations have increased in many remote mountain waterbodies across the western United States, and reports of algal blooms in these systems have increased in frequency. Explanations for observed TP increases are uncertain, and typical landscape drivers, such as agricultural/urban runoff, are implausible. We investigated multiple atmospheric and terrestrial-P loading mechanisms to explain the observed decadal increase in TP, including a novel hypothesis that warming soils may lead to elevated P fluxes to receiving water bodies. Using northern Utah mountains ranges as a case study, we measured prospective inputs of total and bioavailable P via dust deposition. Terrestrial …

Gardens, Religion And Clerical By-Employments: The Dual Careers Of Hugh Hall, Priest-Gardener Of The West Midlands, Susan M. Cogan

History Faculty Publications

Hugh Hall was a highly sought-after gardener in late sixteenth century England. He worked in the Midlands, specifically in Worcestershire, Warwickshire, and Northamptonshire, and mostly for Catholic families. Hall was a Catholic priest who resigned his parish living after the Elizabethan Religious Settlement, but continued to perform clerical duties such as saying Mass and hearing confession alongside his second vocation as a gardener. Indeed, his esteem as a gardener and, later, surveyor of works was strong enough that he attracted Protestant clients like Lord Burghley and Sir Christopher Hatton despite his adherence to Catholicism. Hall's two vocations shaped his identity: …

Utah Women And Stem: A 2022 Update, Rebecca Winkel, Susan R. Madsen

Marketing and Strategy Faculty Publications

According to the U.S. Bureau of Labor Statistics (BLS), careers in STEM (Science, Technology, Engineering, and Math) are expanding faster and pay better than other careers.¹ The median annual wage for STEM occupations in 2020 was nearly $90,000, more than double the median annual wage for all occupations (about $42,000).² STEM opportunities abound in Utah, one of the top 10 states for tech job growth, net tech employment concentration, and net tech employment job gains in 2020.³ In fact, Salt Lake City is ranked the second-best city in the country for professional opportunities in STEM.⁴

Yet, …

Create Better Health Curriculum, Casey Coombs, Jaqueline Neid

All Current Publications

CBH is a comprehensive nutrition curriculum designed to teach adult SNAP-Ed participants how to eat well and be active on a budget. CBH combines nutrition and physical activity recommendations from United States Department of Agriculture (USDA). Each lesson has three components: a nutrition topic based on the current Dietary Guidelines for Americans, a physical activity discussion based on USDA recommendations, and a Create recipe demonstration and sample. The components are woven together in eight lessons that are designed to keep participants engaged, while actively learning the skills needed to create a healthier lifestyle.

An Evaluation Of The Effect Of The Oxycontin Reformulation On Unintentional Fatal And Nonfatal Overdose, Daniel C. Beachler, Kelsey Hall, Renu Garg, Geetanjoli Banerjee, Ling Li, Luke Boulanger, Huseyin Yuce, Alexander M. Walker

Applied Sciences, Technology and Education Faculty Publications

Objectives:

OxyContin was reformulated with a polyethylene oxide matrix in August 2010 to reduce the potential for intravenous abuse and for abuse by insufflation. The objective of this study was to evaluate the impact of OxyContin's reformulation on overdose (OD) risk for individuals dispensed OxyContin in comparison to those dispensed other opioids under regular care.

Materials and Methods:

Three national insurance databases with National Death Index linkage identified OD in individuals with any dispensing of OxyContin or a primary comparator opioid (extended release morphine, transdermal fentanyl, or methadone) between July 2008 through September 2015. A difference-in-differences design was used to …

Voices Of Resiliency: Utah Stories Of Substance Use Disorder, Stigma, & Harm Reduction Foreword, Randy Williams, Sandra H. Sulzer

Voices of Resiliency: Utah Stories of Substance Use Disorder, Stigma, & Harm Reduction

The foreword to the graphic novels in Voices of Resiliency: Utah Stories of Substance Use Disorder, Stigma, & Harm Reduction explains the aims of this community-driven project, including giving voice to the lived experiences and best practices around drug use, recovery, and stigma and harm reduction. The project creators share their hope that the volumes in the series will aid people who use drugs, their families and friends, neighbors, health professionals, educators, first responders, legislators, and people involved in the justice system in their journey regarding substance use disorder and stigma and harm reduction. The foreword acknowledges the generous funders …