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Employing Plant Functional Groups To Advance Seed Dispersal Ecology And Conservation, Clare Aslan, Noelle G. Beckman, Haldre S. Rogers, Judie Bronstein, Damaris Zurell, Florian Hartig, Katriona Shea, Liba Pejchar, Mike Neubert, John Poulsen, Janneke Hillerislambers, Maria Miriti, Bette Loiselle, Edu Effiom, Jenny Zambrano, Eugene W. Schupp, Et Al. Feb 2019

Employing Plant Functional Groups To Advance Seed Dispersal Ecology And Conservation, Clare Aslan, Noelle G. Beckman, Haldre S. Rogers, Judie Bronstein, Damaris Zurell, Florian Hartig, Katriona Shea, Liba Pejchar, Mike Neubert, John Poulsen, Janneke Hillerislambers, Maria Miriti, Bette Loiselle, Edu Effiom, Jenny Zambrano, Eugene W. Schupp, Et Al.

Biology Faculty Publications

Seed dispersal enables plants to reach hospitable germination sites and escape natural enemies. Understanding when and how much seed dispersal matters to plant fitness is critical for understanding plant population and community dynamics. At the same time, the complexity of factors that determine if a seed will be successfully dispersed and subsequently develop into a reproductive plant is daunting. Quantifying all factors that may influence seed dispersal effectiveness for any potential seed-vector relationship would require an unrealistically large amount of time, materials and financial resources. On the other hand, being able to make dispersal predictions is critical for predicting whether …


New Biological Engineering Department Head Named At Usu | College Of Engineering, Utah State University Feb 2019

New Biological Engineering Department Head Named At Usu | College Of Engineering, Utah State University

College of Engineering News

Utah State University’s Department of Biological Engineering is under new leadership. Industry veteran and professor D. Keith Roper took the helm at the department at the beginning of the spring semester. Roper brings a wealth of experience and leadership to the position and says he’s eager to usher in exciting changes.


The Utah Statesman, February 5, 2019, Utah State University Feb 2019

The Utah Statesman, February 5, 2019, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.


Estimability Of Migration Survival Rates From Integrated Breeding And Winter Capture–Recapture Data, Clark S. Rushing Feb 2019

Estimability Of Migration Survival Rates From Integrated Breeding And Winter Capture–Recapture Data, Clark S. Rushing

Ecology Center Publications

Long‐distance migration is a common phenomenon across the animal kingdom but the scale of annual migratory movements has made it difficult for researchers to estimate survival rates during these periods of the annual cycle. Estimating migration survival is particularly challenging for small‐bodied species that cannot carry satellite tags, a group that includes the vast majority of migratory species. When capture–recapture data are available for linked breeding and non‐breeding populations, estimation of overall migration survival is possible but current methods do not allow separate estimation of spring and autumn survival rates. Recent development of a Bayesian integrated survival model has provided …


Climate Change, Woodpeckers, And Forests: Current Trends And Future Modeling Needs, Eric S. Walsh, Kerri T. Vierling, Eva Strand, Kristina Bartowitz, Tara W. Hudiburg Feb 2019

Climate Change, Woodpeckers, And Forests: Current Trends And Future Modeling Needs, Eric S. Walsh, Kerri T. Vierling, Eva Strand, Kristina Bartowitz, Tara W. Hudiburg

Aspen Bibliography

The structure and composition of forest ecosystems are expected to shift with climate‐induced changes in precipitation, temperature, fire, carbon mitigation strategies, and biological disturbance. These factors are likely to have biodiversity implications. However, climate‐driven forest ecosystem models used to predict changes to forest structure and composition are not coupled to models used to predict changes to biodiversity. We proposed integrating woodpecker response (biodiversity indicator) with forest ecosystem models. Woodpeckers are a good indicator species of forest ecosystem dynamics, because they are ecologically constrained by landscape‐scale forest components, such as composition, structure, disturbance regimes, and management activities. In addition, they are …


Panel-Based Exhibit Using Participatory Design Elements May Motivate Behavior Change, Lisa Lundgren, Kathryn A. Stofer, Betty A. Dunckel, Janice Krieger, Makenna Lange, Vaughan James Feb 2019

Panel-Based Exhibit Using Participatory Design Elements May Motivate Behavior Change, Lisa Lundgren, Kathryn A. Stofer, Betty A. Dunckel, Janice Krieger, Makenna Lange, Vaughan James

Instructional Technology and Learning Sciences Faculty Publications

Meaningful science engagement beyond one-way outreach is needed to encourage science-based decision making. This pilot study aimed to instigate dialogue and deliberation concerning climate change and public health. Feedback from science café participants was used to design a panel-based museum exhibit that asked visitors to make action plans concerning such issues. Using intercept interviews and visitor comment card data, we found that visitors developed general or highly individualistic action plans to address these issues. Results suggest that employing participatory design methods when developing controversial socio-scientific exhibits can aid engagement. We conclude by recommending participatory strategies for implementing two-way science communication.


The Birch Creek Canids And Dogs As Transport Labor In The Intermountain West, Martin H. Welker, David A. Byers Feb 2019

The Birch Creek Canids And Dogs As Transport Labor In The Intermountain West, Martin H. Welker, David A. Byers

Sociology, Social Work and Anthropology Faculty Publications

Historically, domestic dogs (Canis familiaris) have been documented as central features of Intermountain West and Great Plains Native American camps. Some of these dogs were bred specifically for largeness and stamina to haul travois and to carry pannier-style packs. Ethnographic accounts frequently highlight the importance of dogs in moving through the Intermountain West and the plains, reporting loads as heavy as 45 kg (100 lbs). We calculated body mass from skeletal morphometric data and used these to estimate prehistoric and historic dog load capacities for travois and pannier-style packs in the Intermountain West, Great Plains, and Great Basin. Specimens of …


Genetic Loci Associated With Salt Tolerance In Advanced Breeding Populations Of Tetraploid Alfalfa Using Genome-Wide Association Studies, Xiang-Ping Liu, Charles Hawkins, Michael D. Peel, Long-Xi Yu Feb 2019

Genetic Loci Associated With Salt Tolerance In Advanced Breeding Populations Of Tetraploid Alfalfa Using Genome-Wide Association Studies, Xiang-Ping Liu, Charles Hawkins, Michael D. Peel, Long-Xi Yu

Plants, Soils, and Climate Faculty Publications

Many agricultural lands in the western United States consist of soil with high concentrations of salt, which is detrimental to alfalfa (Medicago sativa L.) growth and production, especially in the region where water resource is limited. Developing alfalfa varieties with salt tolerance is imperative for sustainable production under increasing soil salinity. In the present study, we used advanced alfalfa breeding populations and evaluated five traits related to salt tolerance including biomass dry weight (DW) and fresh weight (FW), plant height (PH), leaf relative water content (RWC), and stomatal conductance (SC) under control and salt stress. Stress susceptibility index (SSI) …


A Counting-Focused Instructional Treatment To Improve Number Sense: An Exploratory Classroom-Based Intervention Study, Jessica F. Shumway, Patricia S. Moyer-Packenham Feb 2019

A Counting-Focused Instructional Treatment To Improve Number Sense: An Exploratory Classroom-Based Intervention Study, Jessica F. Shumway, Patricia S. Moyer-Packenham

Teacher Education and Leadership Faculty Publications

Developing students’ number sense is a critical area of research in mathematics education because of the role number sense plays in early mathematics learning. In particular, cognitive psychology research has pinpointed verbal counting as a number sense construct that is critical in later mathematics achievement. This study explored variations in 7- and 8-year-old students’ number sense outcomes as they engaged in a counting-focused instructional treatment for differing durations. Sixty students in three elementary classrooms in the United States participated in the counting-focused instructional treatment. A generalized estimating equations (GEE) analysis showed an associated average increase in test scores for students …


Ecological Consequences Of Anomalies In Atmospheric Moisture And Snowpack, Aaron N. Johnston, Jason E. Bruggeman, Aidan T. Beers, Erik A. Beever, Roger G. Christophersen, Jason I. Ransom Feb 2019

Ecological Consequences Of Anomalies In Atmospheric Moisture And Snowpack, Aaron N. Johnston, Jason E. Bruggeman, Aidan T. Beers, Erik A. Beever, Roger G. Christophersen, Jason I. Ransom

Wildland Resources Faculty Publications

Although increased frequency of extreme‐weather events is one of the most secure predictions associated with contemporary climate change, effects of such events on distribution and abundance of climate‐sensitive species remain poorly understood. Montane ecosystems may be especially sensitive to extreme weather because of complex abiotic and biotic interactions that propagate from climate‐driven reductions in snowpack. Snowpack not only protects subnivean biotas from extreme cold, but also influences forage availability through timing of melt‐off and water availability. We related relative abundances of an alpine mammal, the American pika (Ochotona princeps), to measures of weather and snowpack dynamics over an …


Soil And Vegetation Survey Of Antelope Pasture, Curlew Grazing Allotment, Oneida County, Id, Merran Owen, Kari E. Veblen, Thomas A. Monaco, Janis Boettinger Feb 2019

Soil And Vegetation Survey Of Antelope Pasture, Curlew Grazing Allotment, Oneida County, Id, Merran Owen, Kari E. Veblen, Thomas A. Monaco, Janis Boettinger

Wildland Resources Faculty Publications

Antelope Pasture, located in the Black Pine Valley of Oneida County, Idaho, is a 1500-acre portion of the Curlew Grazing Allotment, managed by the Pocatello Field Office of the BLM (Figure 1). The pasture is heavily invaded with exotic annuals such as cheatgrass (Bromus tectorum), halogeton (Halogeton glomeratus), and clasping pepperweed (Lepidium perfoliatum), and grazing is temporarily discontinued. Land-use history of the pasture includes livestock grazing, possible homesteading and cultivation of Agropyron cristatum (crested wheatgrass).


Geospatial Modeling Of Land Cover Change In The Chocó-Darien Global Ecoregion Of South America; One Of Most Biodiverse And Rainy Areas In The World, José Camilo Fagua, R. Douglas Ramsey Feb 2019

Geospatial Modeling Of Land Cover Change In The Chocó-Darien Global Ecoregion Of South America; One Of Most Biodiverse And Rainy Areas In The World, José Camilo Fagua, R. Douglas Ramsey

Ecology Center Publications

The tropical rain forests of northwest South America fall within the Chocó-Darien Global Ecoregion (CGE). The CGE is one of 25 global biodiversity hotspots prioritized for conservation due to its high biodiversity and endemism as well as threats due to deforestation. The analysis of land-use and land-cover (LULC) change within the CGE using remotely sensed imagery is challenging because this area is considered to be one of the rainiest places on the planet (hence high frequency of cloud cover). Furthermore, the availability of high-resolution remotely sensed data is low for developing countries before 2015. Using the Random Forest ensemble learning …


Oxygen Consumption And Sulfate Reduction In Vegetated Coastal Habitats: Effects Of Physical Disturbance, Kasper Elgetti Brodersen, Stacey M. Trevathan-Tackett, Daniel A. Nielsen, Rod M. Connolly, Catherine E. Lovelock, Trisha B. Atwood, Peter I. Macreadie Feb 2019

Oxygen Consumption And Sulfate Reduction In Vegetated Coastal Habitats: Effects Of Physical Disturbance, Kasper Elgetti Brodersen, Stacey M. Trevathan-Tackett, Daniel A. Nielsen, Rod M. Connolly, Catherine E. Lovelock, Trisha B. Atwood, Peter I. Macreadie

Ecology Center Publications

Vegetated coastal habitats (VCHs), such as mangrove forests, salt marshes and seagrass meadows, have the ability to capture and store carbon in the sediment for millennia, and thus have high potential for mitigating global carbon emissions. Carbon sequestration and storage is inherently linked to the geochemical conditions created by a variety of microbial metabolisms, where physical disturbance of sediments may expose previously anoxic sediment layers to oxygen (O2), which could turn them into carbon sources instead of carbon sinks. Here, we used O2, hydrogen sulphide (H2S) and pH microsensors to determine how biogeochemical conditions, and thus aerobic and anaerobic metabolic …


Medication Darts Are Gaining In Popularity - Do They Affect Meat Quality? Are There Risks?, David J. Wilson, Kerry A. Rood Feb 2019

Medication Darts Are Gaining In Popularity - Do They Affect Meat Quality? Are There Risks?, David J. Wilson, Kerry A. Rood

All Current Publications

Livestock, such as beef cattle or post-weaned dairy cattle that are not yet milking, are often relatively “tame” (sometimes the term tame may not apply very well) and can be readily approached within a few feet. However, without adequate restraint facilities or enough personnel, actually treating the livestock is often difficult and can become frustrating and dangerous to people and animals. A solution to this problem, which is being rapidly and increasingly adopted, is the use of medication darts. Nevertheless, many in the cattle industry are raising some concerns. What are some of the characteristics of medication darts? Is there …


Understanding The Basics Of Rabbit Care, Nicloe Reed, Amanda Christensen Feb 2019

Understanding The Basics Of Rabbit Care, Nicloe Reed, Amanda Christensen

All Current Publications

This fact sheet is designed to give anyone interested in owning and raising rabbits an overview of the basics of rabbit care and the resources needed to get started.


The Moral Quandary Of Testing On Animals, Rachel Robinson-Greene Jan 2019

The Moral Quandary Of Testing On Animals, Rachel Robinson-Greene

Languages, Philosophy, and Communication Studies Faculty Publications

The topic of testing on animals as a form of scientific research has been contentious for quite some time. In most cases, the discussion tends to focus on whether it is morally permissible to test various products and procedures on animals in order to determine whether they would be safe and beneficial for human use. Animal experimentation is not always conducted simply for the benefit of human beings—sometimes the parties that stand to benefit from the research are other non-human animals, often including other members of the same species as the animals being tested.


Back To The Future: Conserving Functional And Phylogenetic Diversity In The Amphibian-Climate Refuges, Ricardo Lourenço-De-Moraes, Felipe S. Campos, Rodrigo B. Ferreira, Mirco Solé, Karen H. Beard, Rogério P. Bastos Jan 2019

Back To The Future: Conserving Functional And Phylogenetic Diversity In The Amphibian-Climate Refuges, Ricardo Lourenço-De-Moraes, Felipe S. Campos, Rodrigo B. Ferreira, Mirco Solé, Karen H. Beard, Rogério P. Bastos

Ecology Center Publications

Climate refuges have been used by several species over historical climate change. Ectothermic species often display good models for climate change studies because they are highly sensitive to temperature. Analysis of species loss with ecosystem and evolutionary values helps to understand environmental processes and climate change consequences. We determined the functional and phylogenetic diversity of amphibians in the Atlantic Forest hotspot, using multiple models representing present and future conditions. Through a novel approach, we predict species’ threat status by 2080, following the IUCN’s criterion B1. Our results estimate a drastic reduction in species richness, ecosystem functioning and evolutionary history at …


The Effects Of Electric Power Lines On The Breeding Ecology Of Greater Sage-Grouse, Michel T. Kohl, Terry A. Messmer, Benjamin A. Crabb, Michael R. Guttery, David K. Dahlgren, Randy T. Larsen, Shandra Nicole Frey, Sherry Liguori, Rick J. Baxter Jan 2019

The Effects Of Electric Power Lines On The Breeding Ecology Of Greater Sage-Grouse, Michel T. Kohl, Terry A. Messmer, Benjamin A. Crabb, Michael R. Guttery, David K. Dahlgren, Randy T. Larsen, Shandra Nicole Frey, Sherry Liguori, Rick J. Baxter

Wildland Resources Faculty Publications

Anthropogenic infrastructure can negatively affect wildlife through direct mortality and/or displacement behaviors. Some tetranoids (grouse spp.) species are particularly vulnerable to tall anthropogenic structures because they evolved in ecosystems void of vertical structures. In western North America, electric power transmission and distribution lines (power lines) occur in sagebrush (Artemisia spp.) landscapes within the range of the greater sage-grouse (Centrocercus urophasianus; sage-grouse). The U.S. Fish and Wildlife Service recommended using buffer zones near leks to mitigate the potential impacts of power lines on sage-grouse. However, recommended buffer distances are inconsistent across state and federal agencies because data are …


Predatory Hymenopteran Assemblages In Boreal Alaska: Associations With Forest Composition And Post-Fire Succession, Alexandria Wenninger, Teresa Hollingsworth, Diane Wagner Jan 2019

Predatory Hymenopteran Assemblages In Boreal Alaska: Associations With Forest Composition And Post-Fire Succession, Alexandria Wenninger, Teresa Hollingsworth, Diane Wagner

Aspen Bibliography

Changes to the fire regime in boreal Alaska are shifting the ratio of coniferous to deciduous dominance on the landscape. The increase in aspen and birch may have important effects on predatory hymenopteran assemblages by providing a source of extrafloral nectar and increasing prey availability. Furthermore, fire-induced changes in successional age alter habitat structure and microclimate in ways that may favor ants. This study is the first to characterize the influence of fire-related vegetation changes on boreal predatory hymenopteran assemblages. We compare the abundance, species richness, and composition of predatory hymenopteran assemblages among forests at different stages of succession and …


Neural Correlates Of Interval Timing Deficits In Schizophrenia, Ariel W. Snowden, Catalin V. Buhusi Jan 2019

Neural Correlates Of Interval Timing Deficits In Schizophrenia, Ariel W. Snowden, Catalin V. Buhusi

Psychology Faculty Publications

Previous research has shown that schizophrenia (SZ) patients exhibit impairments in interval timing. The cause of timing impairments in SZ remains unknown but may be explained by a dysfunction in the fronto-striatal circuits. Although the current literature includes extensive behavioral data on timing impairments, there is limited focus on the neural correlates of timing in SZ. The neuroimaging literature included in the current review reports hypoactivation in the dorsal-lateral prefrontal cortex (DLPFC), supplementary motor area (SMA) and the basal ganglia (BG). Timing deficits and deficits in attention and working memory (WM) in SZ are likely due to a dysfunction of …


Major Grant Awarded To Usu Biological Engineering Professor | College Of Engineering, Utah State University Jan 2019

Major Grant Awarded To Usu Biological Engineering Professor | College Of Engineering, Utah State University

College of Engineering News

USU biological engineering assistant professor Elizabeth Vargis received a three-year grant from the National Eye Institute for her ongoing research in better understanding why new blood cells form during retinal disease.


Challenges In Columbia River Fisheries Conservation: A Response To Duda Et Al., Brian K. Hand, Courtney G. Flint, Chris A. Frissell, Clint C. Muhlfeld, Shawn P. Devlin, Brian P. Kennedy, Robert L. Crabtree, W. Arthur Mckee, Gordon Luikart, Jack A. Stanford Jan 2019

Challenges In Columbia River Fisheries Conservation: A Response To Duda Et Al., Brian K. Hand, Courtney G. Flint, Chris A. Frissell, Clint C. Muhlfeld, Shawn P. Devlin, Brian P. Kennedy, Robert L. Crabtree, W. Arthur Mckee, Gordon Luikart, Jack A. Stanford

Sociology, Social Work and Anthropology Faculty Publications

The salmonid fisheries of the Columbia River Basin (CRB) have enormous socioeconomic, cultural, and ecological importance to numerous diverse stakeholders (eg state, federal, tribal, nonprofit), and there are a wide array of opinions and perspectives on how these fisheries should be managed. Although we appreciate Duda et al.'s commentary, it offers only one perspective of many in this context. The objective of our paper (Hand et al. 2018) was to provide justification for “the importance of social–ecological perspectives when communicating conservation values and goals, and the role of independent science in guiding management policy and practice for …


Climate Change Adaptation In The Delta Nile Region Of Egypt: Implications For Agricultural Extension, Hazem S. Kassem, Abdel Raouf Suleiman Bello, Bader M. Alotaibi, Fahd O. Aldosri, Gary S. Straquadine Jan 2019

Climate Change Adaptation In The Delta Nile Region Of Egypt: Implications For Agricultural Extension, Hazem S. Kassem, Abdel Raouf Suleiman Bello, Bader M. Alotaibi, Fahd O. Aldosri, Gary S. Straquadine

Extension Research

This study used quantitative and qualitative methods to collect data, using questionnaires and interviews, from 792 randomly-selected farmers in two of the governorates in the Nile Delta Region, Egypt. A workshop was organized for 59 extension professionals working in the two governorates, looking at how the adaptive capacity of the agricultural sector towards climate change was being guided by policy-makers. Two focus groups were used: one with senior officials from the regional governorates and the other with central government administrators from the Ministry of Agriculture and Land Reclamation. The study findings suggested that 51.9% of the investigated farmers at the …


Exploring Mortality Rates For Major Causes Of Death In Korea, Hyo Jung Oh, Donng Min Yang, Chong Hyuck Kim, Jae Gyu Jeon, Nam Hyung Jung, Chan Young Kim, Jurgen Symanzik, Hyo Won Oh, Akugizibwe Edwin, Seong Ii Jo, Jeong Yong Ahn Jan 2019

Exploring Mortality Rates For Major Causes Of Death In Korea, Hyo Jung Oh, Donng Min Yang, Chong Hyuck Kim, Jae Gyu Jeon, Nam Hyung Jung, Chan Young Kim, Jurgen Symanzik, Hyo Won Oh, Akugizibwe Edwin, Seong Ii Jo, Jeong Yong Ahn

Mathematics and Statistics Faculty Publications

Background: The trends and patterns of the mortality rates for causes of death are meaningful information. They can provide a basis for national demographic and health care policies by identifying the number, causes, and geographical distribution of deaths.

Objective: To explore and analyze the characteristics of the mortality rates for major causes of death in Korea.

Methods: Some common data analysis methods were used to describe the data. We also used some visualization techniques such as heat maps and line plots to present mortality rates by gender, age, and year.

Results: Our analysis shows the crude …


Recoupling Fire And Grazing Reduces Wildland Fuel Loads On Rangelands, Heath D. Starns, Samuel D. Fuhlendorf, R. Dwayne Elmore, Dirac Twidwell, Eric T. Thacker, Torre J. Hovick, Barney Luttbeg Jan 2019

Recoupling Fire And Grazing Reduces Wildland Fuel Loads On Rangelands, Heath D. Starns, Samuel D. Fuhlendorf, R. Dwayne Elmore, Dirac Twidwell, Eric T. Thacker, Torre J. Hovick, Barney Luttbeg

Wildland Resources Faculty Publications

Fire suppression and exclusion, the historically dominant paradigm of fire management, has resulted in major modifications of fire-dependent ecosystems worldwide. These changes are partially credited with a recent increase in wildfire number and extent, as well as more extreme fire behavior. Fire and herbivory historically interacted, and research has shown that the interaction creates a unique mosaic of vegetation heterogeneity that each disturbance alone does not create. Because fire and grazing have largely been decoupled in modern times, the degree to which the interaction affects fuels and fire regimes has not yet been quantified. We evaluated effects of fire-only and …


Weighting Effective Number Of Species Measures By Abundance Weakens Detection Of Diversity Responses, Yong Cao, Charles P. Hawkins Jan 2019

Weighting Effective Number Of Species Measures By Abundance Weakens Detection Of Diversity Responses, Yong Cao, Charles P. Hawkins

Ecology Center Publications

1. The effective number of species (ENS) has been proposed as a robust measure of species diversity that overcomes several limitations in terms of both diversity indices and species richness (SR). However, it is not yet clear if ENS improves interpretation and comparison of biodiversity monitoring data, and ultimately resource management decisions.

2. We used simulations of five stream macroinvertebrate assemblages and spatially extensive field data of stream fishes and mussels to show (a) how different ENS formulations respond to stress and (b) how diversity–environment relationships change with values of q, which weight ENS measures by species abundances.

3. Values …


Generation Of H7n9-Specific Human Polyclonal Antibodies From A Transchromosomic Goat (Caprine) System, Hua Wu, Zhiqiang Fan, Michelle Brandsrud, Qinggang Meng, Molly Bobbitt, Misha Regouski, Rusty Stott, Alexis Sweat, Jackelyn Crabtree, Robert J. Hogan, Ralph A. Tripp, Zhongde Wang, Irina A. Polejaeva, Eddie J. Sullivan Jan 2019

Generation Of H7n9-Specific Human Polyclonal Antibodies From A Transchromosomic Goat (Caprine) System, Hua Wu, Zhiqiang Fan, Michelle Brandsrud, Qinggang Meng, Molly Bobbitt, Misha Regouski, Rusty Stott, Alexis Sweat, Jackelyn Crabtree, Robert J. Hogan, Ralph A. Tripp, Zhongde Wang, Irina A. Polejaeva, Eddie J. Sullivan

Animal, Dairy, and Veterinary Science Faculty Publications

To address the unmet needs for human polyclonal antibodies both as therapeutics and diagnostic reagents, building upon our previously established transchromosomic (Tc) cattle platform, we report herein the development of a Tc goat system expressing human polyclonal antibodies in their sera. In the Tc goat system, a human artificial chromosome (HAC) comprising the entire human immunoglobulin (Ig) gene repertoire in the germline configuration was introduced into the genetic makeup of the domestic goat. We achieved this by transferring the HAC into goat fetal fibroblast cells followed by somatic cell nuclear transfer for Tc goat production. Gene and protein expression analyses …


The Utah Statesman, January 22, 2019, Utah State University Jan 2019

The Utah Statesman, January 22, 2019, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.


Human Polyclonal Antibodies Produced From Transchromosomal Bovine Provides Prophylactic And Therapeutic Protections Against Zika Virus Infection In Stat2 Ko Syrian Hamsters, Venkatraman Siddharthan, Jinxin Miao, Arnaud J. Van Wettere, Rong Li, Hua Wu, Eddie Sullivan, Jinan Jiao, Jay W. Hooper, David Safronetz, John D. Morrey, Justin G. Julander, Zhongde Wang Jan 2019

Human Polyclonal Antibodies Produced From Transchromosomal Bovine Provides Prophylactic And Therapeutic Protections Against Zika Virus Infection In Stat2 Ko Syrian Hamsters, Venkatraman Siddharthan, Jinxin Miao, Arnaud J. Van Wettere, Rong Li, Hua Wu, Eddie Sullivan, Jinan Jiao, Jay W. Hooper, David Safronetz, John D. Morrey, Justin G. Julander, Zhongde Wang

Animal, Dairy, and Veterinary Science Faculty Publications

Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain–Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZIKV infection. Here, we report that ZIKV-specific human polyclonal antibodies (SAB-155), elicited in transchromosomal bovine (TcB), provide significant protection from infection by ZIKV in STAT2 knockout (KO) golden Syrian hamsters both prophylactically and therapeutically. These antibodies also prevent testicular lesions in this hamster model. Our data indicate that antibody-mediated immunotherapy is effective in treating ZIKV infection. Because suitable …


Differential Transcriptome Responses To Aflatoxin B1 In The Cecal Tonsil Of Susceptible And Resistant Turkeys, Kent M. Reed, Kristelle M. Mendoza, Roger A. Coulombe Jr. Jan 2019

Differential Transcriptome Responses To Aflatoxin B1 In The Cecal Tonsil Of Susceptible And Resistant Turkeys, Kent M. Reed, Kristelle M. Mendoza, Roger A. Coulombe Jr.

Animal, Dairy, and Veterinary Science Faculty Publications

The nearly-ubiquitous food and feed-borne mycotoxin aflatoxin B1 (AFB1) is carcinogenic and mutagenic, posing a food safety threat to humans and animals. One of the most susceptible animal species known and thus a good model for characterizing toxicological pathways, is the domesticated turkey (DT), a condition likely due, at least in part, to deficient hepatic AFB1-detoxifying alpha-class glutathione S-transferases (GSTAs). Conversely, wild turkeys (Eastern wild, EW) are relatively resistant to the hepatotoxic, hepatocarcinogenic and immunosuppressive effects of AFB1 owing to functional gene expression and presence of functional hepatic GSTAs. This study was designed to …