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Modeling The Effect Of Observational Social Learning On Parental Decision-Making For Childhood Vaccination And Diseases Spread Over Household Networks, Tamer Oraby, Andras Balogh

School of Mathematical & Statistical Sciences Faculty Publications

In this paper, we introduce a novel model for parental decision-making about vaccinations against a childhood disease that spreads through a contact network. This model considers a bilayer network comprising two overlapping networks, which are either Erdős–Rényi (random) networks or Barabási–Albert networks. The model also employs a Bayesian aggregation rule for observational social learning on a social network. This new model encompasses other decision models, such as voting and DeGroot models, as special cases. Using our model, we demonstrate how certain levels of social learning about vaccination preferences can converge opinions, influencing vaccine uptake and ultimately disease spread. In addition, …

Ivermectin, Colleen Aldous, Eleftherios Gkioulekas, Philip Oldfield

School of Mathematical & Statistical Sciences Faculty Publications

No abstract provided.

Protein Subunit Vaccines: Promising Frontiers Against Covid-19, Vivek P. Chavda, Eswara Naga Hanuma Kumar Ghali, Pankti C. Balar, Subhash Chauhan, Nikita Tiwari, Somanshi Shukla, Mansi Athalye, Vandana Bharat Patravale, Vasso Apostolopoulos, Murali Yallapu

School of Medicine Publications

The emergence of COVID-19 has posed an unprecedented global health crisis, challenging the healthcare systems worldwide. Amidst the rapid development of several vaccine formulations, protein subunit vaccines have emerged as a promising approach. This article provides an in-depth evaluation of the role of protein subunit vaccines in the management of COVID-19. Leveraging viral protein fragments, particularly the spike protein from SARS-CoV-2, these vaccines elicit a targeted immune response without the risk of inducing disease. Notably, the robust safety profile of protein subunit vaccines makes them a compelling candidate in the management of COVID-19. Various innovative approaches, including reverse vaccinology, virus …

Where I Am From Matters: Factors Influencing Behavioral And Emotional Changes In Autistic Individuals During Covid-19 In Latin America, María Cecilia Montenegro, Ana C. Ramirez, Juventino Hernandez Rodriguez, Bianca T. Villalobos, Gabriela Garrido, Cecilia Amigo, Daniel Valdez, Natalia Barrios, Sebastián Cukier, Cecilia Montiel-Nava

Psychological Science Faculty Publications

Background: The COVID-19 pandemic brought an increased incidence of disease and mortality in the world at large, making it a particularly salient and stressful life event. For those individuals residing in Latin America, the pandemic was met with fragmented healthcare systems, economic downturn, and sociopolitical crisis which puts autistic individuals at risk for more detrimental outcomes. Behavioral and emotional challenges experienced by autistic individuals at the beginning of the pandemic could later develop into more severe symptomatology as the pandemic progresses. The present study aimed to explore changes in dysregulated (overt and internalizing) behaviors and preoccupation with getting sick during …

Metagenomic Analysis Unveils The Microbial Landscape Of Pancreatic Tumors, Sheema Khan, Goutam Banerjee, Saini Setua, Daleniece Jones, Bhavin Chauhan, Anupam Dhasmana, Pratik Banerjee, Murali M. Yallapu, Stephen Behrman, Subhash C. Chuahan

School of Medicine Publications

The composition of resident microbes in the human body is linked to various diseases and their treatment outcomes. Although studies have identified pancreatic ductal adenocarcinoma (PDAC)-associated bacterial communities in the oral and gut samples, herein, we hypothesize that the prevalence of microbiota in pancreatic tumor tissues is different as compared with their matched adjacent, histologically normal appearing tissues, and these microbial molecular signatures can be highly useful for PDAC diagnosis/prognosis. In this study, we performed comparative profiling of bacterial populations in pancreatic tumors and their respective adjacent normal tissues using 16S rRNA-based metagenomics analysis. This study revealed a higher abundance …

Safety And Immunogenicity Of An In Vivo Muscle Electroporation Delivery System For Dna-Hsp65 Tuberculosis Vaccine In Cynomolgus Monkeys, Monique Ribeiro De Lima, Ana C. Leandro, Andreia Lamoglia De Souza, Marcio Mantuano Barradas, Eric Henrique Roma, Ana Teresa Gomes Fernandes, Gabrielle Galdino-Silva, Joyce Katiuccia M. Ramos Carvalho, Renato Sergio Marchevsky, John L. Vandeberg

School of Medicine Publications

A Bacille Calmette–Guérin (BCG) is still the only licensed vaccine for the prevention of tuberculosis, providing limited protection against Mycobacterium tuberculosis infection in adulthood. New advances in the delivery of DNA vaccines by electroporation have been made in the past decade. We evaluated the safety and immunogenicity of the DNA-hsp65 vaccine administered by intramuscular electroporation (EP) in cynomolgus macaques. Animals received three doses of DNA-hsp65 at 30-day intervals. We demonstrated that intramuscular electroporated DNA-hsp65 vaccine immunization of cynomolgus macaques was safe, and there were no vaccine-related effects on hematological, renal, or hepatic profiles, compared to the pre-vaccination parameters. No tuberculin …

Activity Patterns Of The Endangered Amargosa Vole (Microtus Californicus Scripensis), Austin N. Roy, Anna D. Rivera Roy, Deana L. Clifford, Janet E. Foley

School of Earth, Environmental, & Marine Sciences Faculty Publications

Examining the activity patterns of wildlife is an important aspect of understanding the ecology of a species and may be especially important for species of conservation concern. We used remotely triggered cameras to describe the daily and seasonal activity patterns and examine ecological factors that influence the activity of the Amargosa Vole (Microtus californicus scirpensis), a California endemic listed federally and by the state as Endangered, and is a marsh habitatspecialist in the Mojave Desert. We found that vole activity was greatest during crepuscular periods, followed by nocturnal and diurnal periods. We saw strong seasonal effects, with the highest activity …

Aedes Aegypti Host Preference On Canines Versus Human Volatile Skin Compounds, Melissa Bernadette Rosalez

Theses and Dissertations

It is critical to understand how Aedes aegypti mosquitoes detect hosts through cues such as volatile skin compounds. In South Texas, evidence suggests that this mosquito is showing a feeding preference for canines over humans. This shift may impact the transmission of Dirofilaria immitis, canine heart worms, in local dog populations. Our study is set to explore Ae. Aegypti attraction to hosts using canine and human volatile compounds. Volatile skin compounds will be collected using a volatile collection system. Compounds will be analyzed using gas chromatography/mass spectrometry. It is anticipated that the main volatile skin compounds amongst humans are nonanal, …

Growth Rates, Morphology, And Potential For Mariculture Of The Southern Population Of Crassostrea Virginica In The Lower Laguna Madre, Texas, Jerad Lee Fuelling

Theses and Dissertations

The Eastern Oyster also known as Crassostrea virginica, is an important resource here in the United States. Historically, this species has been overfished, poorly managed, and plagued by disease. Oyster mariculture is a growing industry here in the United States and is a sustainable solution to producing oysters. Texas has become the last coastal state to legalize oyster mariculture which means there is now a vast coastline with many unique bay systems that are open to this industry. One bay system that is particularly unique is the Lower Laguna Madre which is a hypersaline lagoon. Little is known about …

An Automatic Solver For Optimal Control Problems, Marcel Efren Benitez

Theses and Dissertations

Optimal control theory is a study that is used to find a control for a dynamical system over a period of time such that a objection function is optimized. In this study we will be looking at optimal control problems for ordinary differential equations or ODEs and see that we can use an automatic solver using the forward-backward sweep using Matlab to solve for them from an 1 dimension to bounded cases and to nth dimension cases.

The Impacts Of Caregiving And Social Support On Stress For Multiple Sclerosis: A Study On Informal Caregivers, Jacqueline Mercado

Theses and Dissertations

The purpose of the present quantitative study was to gain an increased understanding of the impacts of caregiving and social support on stress for unpaid informal caregivers of persons with Multiple Sclerosis. Caregiving for MS can be rewarding yet stressful. Informal caregivers are the primary source of ongoing home care for family members or friends with MS. Due to the complexity of care, caregivers are especially vulnerable to higher strain as they often feel unprepared for this role. This study examined perceived social support and demographic variables on caregivers' stress to gain insight into mediating caregiver psychosocial challenges. …

The Rarest Among The Rare? Acrometastases And Disability In The Past And Beyond, Nathalie Antunes-Ferreira, Francisco Curate, Carlos Prates, Benoit Bertrand, Carina Marques

Anthropology Faculty Publications

Metastatic bone disease significantly impacts cancer-related morbidity and mortality nowadays. Herein, we present an adult individual, probably a female, with multiple osteolytic lesions, of variable sizes, distributed predominantly in the axial skeleton but also affecting elements of the appendicular region. This individual also exhibits atypical manifestations of metastatic bone disease, in the form of acrometastases—metastases in the extremities, which are uncommon events in current clinical settings. The individual's skeletonized remains were exhumed from a crypt in the Chapel of the Holy Spirit (Espírito Santo), Loures, Portugal, and have been dated from the 16th to 19th centuries. The multiple …

Global Variation In Diabetes Diagnosis And Prevalence Based On Fasting Glucose And Hemoglobin A1c, Ncd Risk Factor Collaboration (Ncd-Risc), Bin Zhou, Kate E. Sheffer, James E. Bennett, Edward W. Gregg, Goodarz Danaei, Rosie K. Singleton, Jonathan E. Shaw, Gladys Maestre, Jesus D. Melgarejo

School of Medicine Publications

Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed …

Limited Clinical Utility Of Routine Mycobacterial Cultures For The Management Of Diabetic Foot Infections, Laila M. Castellino, Clare Mccormick-Baw, Tyler Coye, Peter A. Crisologo, John J. Hanna, Francesca Lee, Andrew Clark, Michael Fanning, Amanda L. Killeen

School of Podiatric Medicine Publications

Mycobacterial infections of the foot and ankle are uncommon. In a cohort of 2340 patients with diabetic foot infection (DFI) in a region with increased prevalence of mycobacterial disease, we identified no clinically significant positive cultures over a 3-year period. Routine mycobacterial culture of DFIs is of limited clinical utility.

Documenting Working Experiences Of Agricultural Workers In California, Alvaro Medel-Herrero, Natalia Deeb-Sossa, Monica Torreiro-Casal, Martha Shumway, Joseph D. Hovey, Rosemary Sokas

Psychological Science Faculty Publications

Over 800,000 Latina/o agricultural workers are employed in California every year, of whom approximately 400,000 are estimated to be undocumented immigrants. We convened 19 focus groups (FG) between July 2019 and January 2020 in various regions of California to gather information from Latina/o agricultural workers on social stressors. The participants’ narratives focused extensively on working conditions. This paper analyses these narratives and examines working and living conditions, as well as the combined effect of profound deprivations within most significant social domains. Agricultural workers in California characterise their working conditions as little better than slave labour. Systematic abusive practices and exploitation, …

A Case Report Of Candida-Induced Emphysematous Gastritis, Natalia Pinto, Jorge Nadal, Yilen Karen Ng-Wong, Michael Menowsky, Ryan Shine, Javier Malcom, Mario Moya, Julian Galindo, Samuel Serna

School of Medicine Publications

Emphysematous gastritis is a rare entity that has not much literature available. It is known to manifest as a diffused wall inflammation and air within the wall of the stomach and has been associated with gas-forming organisms.

We present a complex case of a middle-aged woman with a previous history of fulminant Clostridium difficile complicated with colectomy and diverting colostomy. She was admitted due to diabetic ketoacidosis, later complicated with worsening abdominal pain, and a CT scan of the abdomen and pelvis without contrast revealed findings consistent with ischemic bowel, severe pneumatosis intestinalis, and extensive portal venous gas. A stomach …

Tuberculosis Presentation And Outcomes In Older Hispanic Adults From Tamaulipas, Mexico, Belinda Medrano, Miryoung Lee, Gretchen L. Gemeinhardt, Javier E. Rodríguez-Herrera, Moncerrato García-Viveros, Blanca I. Restrepo

School of Medicine Publications

Older people are at high risk of developing and dying from pulmonary infections like tuberculosis (TB), but there are few studies among them, particularly in Hispanics. To address these gaps, we sought to identify host factors associated with TB and adverse treatment outcomes in older Hispanics by conducting a cross-sectional study of TB surveillance data from Tamaulipas, Mexico (2006–2013; n = 8381). Multivariable logistic regressions were assessed for older adults (OA ≥65 years) when compared to young (YA, 18–39 years) and middle-aged adults (40–64 years). We found that the OA had features associated with a less complicated TB (e.g., lower …

Acute Aseptic Meningoencephalitis Due To Covid-19 In An Otherwise Healthy Patient: A Case Report, Shyama Appareddy, Norma Moncayo, Ronkino T. Mccoy, Jared Sperling, George Huddleston, Raza L. Kahn

Research Colloquium

Several studies have shown the extrapulmonary manifestations of COVID-19 disease caused by the SARS-CoV2 virus. Although extrapulmonary manifestation to the heart, kidney, blood, and skin are common, neurological and cerebrovascular manifestations are rare with most of these cases being described in patients who also have the pulmonary manifestation of the disease. Here we present the case of an 18 year-old male with no prior history of respiratory symptoms who presented to the emergency department with altered mental status. Neurology was consulted and the patient was started empirical on ceftriaxone, vancomycin, dexamethasone, and acyclovir for meningoencephalitis. Urine drug screen, head CT, …

Disseminated Cryptococcosis In Solid Organ Transplant Recipient, Sonal V. Jha, Tomas V. Gonzalez, Chelsea H. Chang

Research Colloquium

Introduction: Invasive fungal diseases (IFD) have an overall incidence of 3.1% in solid organ transplant (SOT) patients.1 Although rare, they result in high mortality, likely due to a delay in treatment caused by inherent delay of fungal culture-based diagnosis.2-5 Cryptococcus are the third most common cause of fungal infection in SOT patients. 6-7

Objective: Here we present a unique case of disseminated cryptococcosis in a patient who underwent kidney transplantation with rapid symptomatic onset and presence of perinephric and perihepatic abscesses. The findings presented may inform clinicians of the potentially unusual manifestations of common fungal infections in solid organ transplant …

Antibiotic Stewardship In Skin And Soft Tissue Infections, Shah Z. Ali, Stephen Gore, Jose E. Campo Maldonado

Research Colloquium

Introduction: Skin and soft tissue infections (SSTIs) are characterized by microbial invasion of the skin layers and are common in various healthcare settings. A study conducted between 2005-2010 in the United States, found a combined total of 2.3 million cases of SSTIs in ambulatory and inpatient settings. This was higher than the rates of pneumonia and urinary tract infections during the same time period. Another study found that between 2000 and 2012, there was a 40% increase (2.4 million to 3.3 million) in cases of SSTIs. Our aim is to study the primary uses of vancomycin and piperacillin/tazobactam and their …

Rare Case Of Prosthetic Joint Infection Caused By Salmonella Enterica - A Case Report, Carlos Ramos, Shyama Appareddy, Peter J. Gonzalez

Research Colloquium

Introduction: Collectively, over 1 million total knee arthroplasties (TKA) and total hip arthroplasties (THA) are performed in the United States each year. In 2010 it was estimated that 1.58% of the United States general population has received a TKA. Prosthetic joint infections (PJI) are the most common indication for a TKA revision1 . In total, S. aureus is responsible for about 50% of all prosthetic joint infections, and about 15% are caused by gram negative pathogens2 .

Objective: This is a case report which describes the presentation and clinical course of a 59-yearold female with Salmonella enterica septic arthritis of …

Development Of Targeted Drug Delivery System To Improve Immunotherapy In Pancreatic Cancer, Poornima Devi Shaji, Ana Martinez Bulnes, Nirnoy Dan, Subhash C. Chauhan, Sheema Khan, Murali M. Yallapu

Research Colloquium

Introduction: About 95% of tumor arises from epithelial cell lining ducts known to be pancreatic ductal adenocarcinomas, with less than 5-7% survival rate. Unfortunately, little progress has been seen in the outcomes of patients with PDAC as tumor develops high desmoplasia and chemo-resistance to chemotherapeutic drugs, such as gemcitabine (Gem). Immunotherapy has shown promising results in other cancers but limited response in pancreatic cancer due to desmoplasia and fibrotic tumor microenvironment. A recently identified mucin, MUC13 is aberrantly expressed in pancreatic tumors but not in normal pancreas. Due to its high membrane expression, MUC13 may serve as an excellent target …

Antifungal Prophylaxis And Risk For Invasive Mold Infections In Children With Hematologic Malignancies, Ashley Ikwuezunma, Ankhi Dutta, Maria I. Castellanos, Hana Paek, Debra L. Palazzi, Karen R. Rabin, Michael E. Scheurer, Maria M. Gramatges

Research Colloquium

Introduction: Invasive mold infections (IMI) are a leading cause of mortality in immunocompromised hosts. Children diagnosed with hematologic malignancies experience profound, prolonged neutropenia following intensive chemotherapy, and are at increased risk for infection-related outcomes. Depending on the anticipated therapeutic intensity, antimicrobial prophylaxis may be employed to mitigate risk for infection. We conducted a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), or lymphoma between 2006-2015 and determined the incidence of IMI to be 4.8% (47/976), with an exceptionally high incidence observed in patients with AML (8.1%). This observation prompted a change in clinical practice …

The Unusual Opportunistic Pathogen With Superbug Potential: A Case Of Morganella Morganii Bacteremia, Rodolfo Singleterry, Khairiya Haj-Yahya

Research Colloquium

Morganella. morganii is considered a rare and unusual cause of infection despite its vast presence worldwide. Recently there has been increasing documentation of its opportunistic ability to infect immunocompromised patients, most notably in intensive care units.

The patient is a 55-year-old female with a past medical history of diabetes mellitus(II), end-stage renal disease, hypertension, dyslipidemia, and a left above-knee amputation. She presented with shortness of breath, hypotension, and difficulties staying awake. Blood pressure on admission was 92/48 with an oxygen saturation of 82%. On physical exam, a 3cm linear non-purulent wound was found on the dorsum of her right foot. …

Multisystem Inflammatory Syndrome In Children (Mis-C): Is There A Relationship To Typhus?, Sravani Mannuru, Juliana Hager, Jacob Smith

Research Colloquium

The United Kingdom first reported in April 2020 a group of eight previously healthy children with a link to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that presented with systemic inflammation and multi-organ involvement, now named multisystem inflammatory syndrome in children (MIS-C). The Centers of Disease Control and Prevention (CDC) have reported over 1000 cases since the primary discovery as of October 2020 with 20 total deaths. [1] The clinical features of MIS-C have been previously compared to inflammatory syndromes including Kawasaki disease (KD) and toxic shock syndrome (TSS). We describe the clinical presentation and management for 3 pediatric cases with …

Cmv? An Uncommon Etiology For Significant Disease In The Immunocompetent Individual, Ashley Sareen, Cade Call, Sonya Saenz

Research Colloquium

A 51-year-old Hispanic male with Type 2 diabetes mellitus and dyslipidemia was admitted from the ED for evaluation of recurrent fevers, multiple joint pains, and tachycardia. Physical exam findings included cachectic appearance and right inguinal lymphadenopathy. Initial laboratory testing was significant for a WBC of 23,300 (80.2% neutrophils, 13.3% lymphocytes), Hb of 11.1, HCT of 33.1, and ESR of 120. Chest x-ray reported no acute findings and x-ray imaging of affected joints were unremarkable. Blood and urine cultures would eventually return negative. Despite acetaminophen and broad-spectrum antibiotic use, the patient continued with fevers and tachycardia, prompting further infectious and rheumatological …

How To Get Ripped Muscles In 7 Days: A Case Of Daptomycin-Induced Rhabdomyolysis, Khairiya Haj-Yahya, Rodolfo Singleterry

Research Colloquium

In phase III clinical trials, the use of Daptomycin was associated with an increase in creatinine phosphokinase (CPK) levels in 2.8% of patients treated. Elevation of CPK levels greater than 5 times the upper limit of normal (10-120 mcg/L), indicates a probable diagnosis of rhabdomyolysis. Rhabdomyolysis is the breakdown of skeletal muscle and subsequent leakage of contents into the blood, causing extreme weakness and pain.

A 50-year-old male with a past medical history of chronic osteomyelitis, presented to the ED with right foot pain with swelling. He was subsequently started on Daptomycin. During this time his CPK level was within …

The Accumulation And Growth Of Pseudomonas Aeruginosa On Surfaces Is Modulated By Surface Mechanics Via Cyclic-Di-Gmp Signaling, Liyun Wang, Yu-Chern Wong, Joshua M. Correira, Megan Wancura, Chris J. Geiger, Shanice S. Webster, Ahmed Touhami, Benjamin J. Butler, George A. O’Toole, Richard M. Langford

Physics & Astronomy Faculty Publications

Attachment of bacteria onto a surface, consequent signaling, and accumulation and growth of the surface-bound bacterial population are key initial steps in the formation of pathogenic biofilms. While recent reports have hinted that surface mechanics may affect the accumulation of bacteria on that surface, the processes that underlie bacterial perception of surface mechanics and modulation of accumulation in response to surface mechanics remain largely unknown. We use thin and thick hydrogels coated on glass to create composite materials with different mechanics (higher elasticity for thin composites; lower elasticity for thick composites) but with the same surface adhesivity and chemistry. The …

A Case Of Disseminated Cryptococcosis, Suneet Johal, Shadi Jafari-Esfahani, Maria Najam, Luis Rosas

Research Colloquium

Background: Cryptococcus is an invasive fungal infection, typically acquired through inhalation. It is found in soil contaminated with bird droppings and it can disseminate to the lungs, meninges, and skin. In the United States, the incidence of cryptococcosis is estimated to be about 0.4-1.3 cases per 100,000 population with the most common species being Cryptococcus Neoformans and Cryptococcus Gatti. Cryptococcosis is commonly seen in HIV patients, however, immunocompromised individuals with cancer, solid organ transplants, or chronic glucocorticoid therapy are also at high risk.

Case Presentation: A 69-year-old male with history of polymyositis and granulomatosis polyangiitis on chronic steroids presents to …

Pneumocystis Jirovecii Pneumonia In A Newly Diagnosed Aids Geriatric Patient, Ashley Sareen, Nathan Tanner, James Fahey

Research Colloquium

Background: Approximately 40% of new HIV infections originate from people who are unaware of their diagnosis. Median time from infection to diagnosis was 3 years in 2015. Cases of newly diagnosed HIV in the geriatric population are rare.

Case Presentation: 71 year old Hispanic man with history of diabetes and anemia presenting to the hospital with generalized weakness, presyncopal episodes, shortness of breath, loose stools, and falls for past two weeks. He is a poor historian so wife contacted to provide detailed history. Patient with 100 pound weight loss in 6 months. Intravenous drug use 30 years ago, and blood …