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Forward, Amy Hamilton Jun 2025

Forward, Amy Hamilton

Military Cyber Affairs

No abstract provided.


Understanding Russia’S Cyber Policies, Strategies, And Doctrines, Bryan Hancock, Hanh Nguyen, Olga Karpoyan, Ekzhin Ear, Shouhuai Xu Jun 2025

Understanding Russia’S Cyber Policies, Strategies, And Doctrines, Bryan Hancock, Hanh Nguyen, Olga Karpoyan, Ekzhin Ear, Shouhuai Xu

Military Cyber Affairs

This study analyzes the strengths and weaknesses of Russia’s cyber policies, strategies, and doctrines through a systematic set of attributes, leading to key insights: (i) Russia has proactively adapted its cyber policies, strategies, and doctrines to its evolving environment; (ii) Russia actively conducts cognitive warfare, but remains equally vulnerable to it; and (iii) Russia’s cyber posture faces significant challenges, including a limited technological base, shortage of skilled personnel, and restrictive approach to information control, all of which undermine the effectiveness of its strategies. These insights offer valuable implications for US Cyber Command and the Department of Defense.


Characterizing Cyberattacks Against Operational Technology Infrastructures Through The Lens Of Attack Flows, Sherman Kettner, Caleb Chang, Ekzhin Ear, Shouhuai Xu Jun 2025

Characterizing Cyberattacks Against Operational Technology Infrastructures Through The Lens Of Attack Flows, Sherman Kettner, Caleb Chang, Ekzhin Ear, Shouhuai Xu

Military Cyber Affairs

Operational Technology (OT) infrastructures play a critical role in modern society and economy. However, their increasing connectivity with public networks such as the Internet has made them vulnerable to cyberattacks, much like traditional Information Technology (IT) systems. In particular, cyberattacks against OT infrastructures remain relatively underexplored and little understood. In this paper, we aim to deepen our understanding of cyberattacks against OT infrastructures. For this purpose, we propose a methodology, including novel cybersecurity metrics to analyze the attack flows of these attacks in an end-to-end fashion, which allows us to draw useful insights. We demonstrate the utility of the methodology …


On Some Hypergraph Coloring Algorithms, Boyoon Lee Jun 2025

On Some Hypergraph Coloring Algorithms, Boyoon Lee

USF Tampa Graduate Theses and Dissertations

Of a given bipartite graph G = (V, E), it is elementary to construct a bipartition in timeO(|V |+|E|). For a given k-graph H = H(k) with k ≥ 3 fixed, Lovász proved that deciding whether H is bipartite is NP-complete. In this thesis, we consider the average running time of this problem. For that, let B_n = (B^(k))_n be the collection (family) of all bipartite k-graphs H on the fixed vertex set [n] = {1, ...., n}. We construct, of a given H ∈ B_n, a bipartition in time averaging O(n^k) over the class B_n. We provide two proofs …


Which Adolescents Benefit Most From Positive Psychology Interventions: Examining The Common Factors Of Therapeutic Change, Nicolette Bauermeister Jun 2025

Which Adolescents Benefit Most From Positive Psychology Interventions: Examining The Common Factors Of Therapeutic Change, Nicolette Bauermeister

USF Tampa Graduate Theses and Dissertations

The literature has found positive psychology interventions to be effective at improving the subjective well-being of youth (Tejada-Gallardo et al., 2020). Further research is needed to identify variables such as common factors of change that could be contributing to whether youth report improved outcomes after participating in a positive psychology intervention. This study examined common factors of therapeutic change as predictors for outcomes such as positive affect, negative affect, and life satisfaction, which are components of subjective well-being. This dissertation aimed to fill the gap in the literature regarding common factors of change as predictors of outcomes in school-based positive …


Transatlantic Forum On Cybersecurity, Nicolas Sabouret, Julien Signoles, Marbin Pazos Revilla Jun 2025

Transatlantic Forum On Cybersecurity, Nicolas Sabouret, Julien Signoles, Marbin Pazos Revilla

GNSI Conference Reports

On June 23, 2025, the Global and National Security Institute (GNSI) in partnership with the University of Paris-Saclay’s Graduate School of Computer Science, the Florida Center for Cybersecurity and the University of South Florida Bellini College of Artificial Intelligence, Cybersecurity and Computing held the Transatlantic Forum on Cybersecurity. This international virtual event brought together leading academics to examine some of the most pressing cybersecurity issues of today. Thought-provoking discussions touched on formal models for cybersecurity, network security and the implications and policies for evolving cybersecurity threats.


Algorithms Of Eversion: Contemporary States And Digital Sovereigns, James Libengood Jun 2025

Algorithms Of Eversion: Contemporary States And Digital Sovereigns, James Libengood

USF Tampa Graduate Theses and Dissertations

The rapid development of artificial intelligence (AI), the internet of things (IoT), and digitization have pushed digital sovereignty to the top of the governance agenda in the 21st century. This notion is expanded upon in this work through seven chapters encompassing theoretical underpinnings, methodological frameworks, and real-world case studies. It shows how multinational corporations dominate digital coloniality, and how the merge of physical and digital reality or eversion poses challenges. The study compares contrasting governance approaches, such as the European Union’s General Data Protection Regulation (GDPR), geared to ethical AI and data protection, versus BRICS nations’ stance on data localization …


The Only Constant Is Change: The Role Of Genetic Diversification In Cancer And Beyond, Malgorzata Tyczynska Weh Jun 2025

The Only Constant Is Change: The Role Of Genetic Diversification In Cancer And Beyond, Malgorzata Tyczynska Weh

USF Tampa Graduate Theses and Dissertations

Genetic diversification, the process by which genetic variation arises in a population, is fundamental to evolution by natural selection. Mutation, a central diversification process, fuels adaptation across species, including in cancer. Yet most new mutations are neutral or deleterious on cell fitness, raising the question of how mutation-driven adaptation persists. To explore this paradox, I developed a spatial agent-based model (ABM) in which population fitness emerges from individual cells acquiring mutations at varied rates and with diverse fitness effects. I evaluated model behavior across adaptive states, mutation rates, and distributions of fitness effects. The results show that high mutation rates …


Exploring Culturally Responsive Literacy Practices In Prekindergarten: A Multimodal Approach By Teachers, Deeksha Thonta Aradhya Jun 2025

Exploring Culturally Responsive Literacy Practices In Prekindergarten: A Multimodal Approach By Teachers, Deeksha Thonta Aradhya

USF Tampa Graduate Theses and Dissertations

Children from culturally and ethnically diverse backgrounds are often expected to learn within different cultural contexts than those they have experienced in their families, homes, and communities. Some children are rarely exposed to the dominant culture and practices that are highly valued in schools before entering early education settings. When they start (pre)school, young children are often expected to immediately participate in cultural practices that may differ from those at home, which are considered indicative of being successful, ready, or capable. This research aimed to investigate the culturally responsive literacy practices used by teachers in a laboratory prekindergarten classroom. The …


Cinematic Abuse: A Critical Analysis Of Disney’S “Happily Ever After” In The Little Mermaid, Aladdin, And The Princess And The Frog, Erin Michelle Gough Jun 2025

Cinematic Abuse: A Critical Analysis Of Disney’S “Happily Ever After” In The Little Mermaid, Aladdin, And The Princess And The Frog, Erin Michelle Gough

USF Tampa Graduate Theses and Dissertations

This dissertation examines the manner in which three animated Disney princess films cultivate stereotypes and gendered behaviors consistent with domestic violence and thereby encourages viewers to accept and tolerate abuse against women. I argue that due to the dangerous, constricting, and sexist gender roles encouraged by the Walt Disney Corporation, films prime young girls and boys to react to social situations and encounters in a way that mirror the characters’ reactions. Because of the films’ entertainment value, most of the characters’ inappropriate, stereotypical, and often violent behaviors either go unnoticed or are passively accepted. The violence does not have to …


The Epistemologization Of Scientific Knowledge: Scientific Textbooks And Education In The 18th And 19th Centuries, Brian P. Bieganski Jun 2025

The Epistemologization Of Scientific Knowledge: Scientific Textbooks And Education In The 18th And 19th Centuries, Brian P. Bieganski

USF Tampa Graduate Theses and Dissertations

Philosophy, despite its proclivities towards history and contextualization, often neglects to properly note various characteristics of ideas. In particular, there seems to be a kind of blindness to a key component of how ideas come into being: namely, the role of writing that leads to the preservation and transmission of ideas. Textbooks, for instance, are a key instrument for containing, disseminating, and archiving knowledge of a specific domain that can be used to introduce those complex concepts to newcomers and the unspecialized. As such, a textbook is an epistemic device used for transmitting a condensed constellation of ideas, concepts, formulas, …


First Insight On The Genesis Of Iron Oxide-Hydroxide Biospeleothems In Rancho Chico Lava Tube, Mexico, Rafael López-Martínez, Elizabeth Solleiro-Rebolledo, Rocio Alcántara-Hernández, Teresa Pi Puig, Sergey Sedov, Daisy Valera Fernández, M. Nayeli Luis-Vargas, Yasmany Lima Vera, Jesús Solé, Ramon Espinasa-Pereña Jun 2025

First Insight On The Genesis Of Iron Oxide-Hydroxide Biospeleothems In Rancho Chico Lava Tube, Mexico, Rafael López-Martínez, Elizabeth Solleiro-Rebolledo, Rocio Alcántara-Hernández, Teresa Pi Puig, Sergey Sedov, Daisy Valera Fernández, M. Nayeli Luis-Vargas, Yasmany Lima Vera, Jesús Solé, Ramon Espinasa-Pereña

International Journal of Speleology

Iron is a common element in lava tube systems, typically observed as thin crusts or inferred from the reddish coloration of secondary mineral deposits. In this study, we describe iron oxide-hydroxide biospeleothems discovered in the Rancho Chico Lava Tube, located within the Xalapa Monogenetic Volcanic Field in Mexico. We adopt an integrative approach combining petrography, soil micromorphology, scanning electron microscopy, mineralogy, and 16S rRNA gene metabarcoding. DNA sequencing reveals the presence of microorganisms such as Acidithiobacillus, Gallionella, and members of the Leptospirillaceae family, which may be involved in the oxidation of Fe²⁺ within the lava tube. The source …


Evaluating Behavioral Skills Training To Teach Salsa Dancing Skills To Adults With Autism Spectrum Disorder And/Or Intellectual Disabilities, Joshua I. Nieves Jun 2025

Evaluating Behavioral Skills Training To Teach Salsa Dancing Skills To Adults With Autism Spectrum Disorder And/Or Intellectual Disabilities, Joshua I. Nieves

USF Tampa Graduate Theses and Dissertations

Research has demonstrated behavioral skills training (BST) to be an effective teaching procedure for acquisition of a variety of skills among both neurotypical and neurodiverse individuals across different ages. Moreover, recent studies have demonstrated the effectiveness of BST for enhancing sports performance when training neurotypical children and adults. However, there is limited research on the effectiveness of BST for enhancing sports performance, and specifically dance performance, among individuals with autism spectrum disorder (ASD) and/or intellectual disabilities (ID). Dance is a recreational activity that can serve as a form of physical activity for children and adults. Salsa is a Latin style …


Hierarchical Reinforcement Learning (Hrl) In Multi-Goal Spatial Navigation With Autonomous Mobile Robots, Brendon Johnson Jun 2025

Hierarchical Reinforcement Learning (Hrl) In Multi-Goal Spatial Navigation With Autonomous Mobile Robots, Brendon Johnson

USF Tampa Graduate Theses and Dissertations

Hierarchical reinforcement learning (HRL) is hypothesized to be able to take advantage of the inherent hierarchy in robot learning tasks with sparse reward schemes, in contrast to more traditional reinforcement learning algorithms. In this research, hierarchical reinforcement learning is evaluated and contrasted with standard reinforcement learning in complex navigation tasks. We evaluate unique characteristics of HRL, including their ability to create sub-goals and the termination function. We constructed experiments to test the differences between PPO and HRL, different ways of creating sub-goals, manual vs automatic sub-goal creation, and the effects of the frequency of termination on performance. These experiments highlight …


Untangling The Threads Of Hope: A Qualitative Media Analysis Of Discourse Relating To Futures For Sickle Cell Disease, Amanda R. Malerba Jun 2025

Untangling The Threads Of Hope: A Qualitative Media Analysis Of Discourse Relating To Futures For Sickle Cell Disease, Amanda R. Malerba

USF Tampa Graduate Theses and Dissertations

Sickle cell disease (SCD) is the most common inherited blood disorder worldwide, with a disproportionate burden on people of African ancestry. Life with this illness is characterized by chronic physical pain, overlapping health conditions, and often early death. In the United States, the physical symptoms of the disease are frequently compounded by experiences of racial inequality and oppression embedded in the medical system that contribute to detrimental outcomes. Because of the complex biocultural web of factors contributing to the suffering of people with SCD, much of the anthropological scholarship surrounding this illness prioritizes deconstructing systems of power, oppression, and inequality. …


Sense Of Immortality As A Death Anxiety Buffer: An Investigation Through Awe, Sabrina J. Eisenberg Jun 2025

Sense Of Immortality As A Death Anxiety Buffer: An Investigation Through Awe, Sabrina J. Eisenberg

USF Tampa Graduate Theses and Dissertations

This thesis investigated the emotion awe as protective against mortality salience by fulfilling sense of immortality – a proposed need created by mortality salience. Mortality salience has been shown to increase cultural worldview defense, which sometimes has detrimental social effects. This study aimed to test if inducing feelings of awe would reduce the need to rely on cultural worldview defense in response to mortality salience. The pilot study (N = 239) found evidence for a relationship between awe and sense of immortality. The primary study (N = 167) tested a main effect of mortality salience on cultural worldview defense (H1) …


An Application Of A Positive Psychology Intervention To Promote The Well-Being Of Children With Cancer, Jenna Barnes Jun 2025

An Application Of A Positive Psychology Intervention To Promote The Well-Being Of Children With Cancer, Jenna Barnes

USF Tampa Graduate Theses and Dissertations

The psychological impact of pediatric cancer and cancer treatment is not well understood. Although there is evidence to suggest that pediatric cancer may negatively impact youth’s mental health and psychological functioning, other research suggests that the mental health of children with cancer is similar to that of healthy peers. Traditional psychological interventions have been used to reduce symptoms of psychopathology among children with cancer. However, less is known about the subjective well-being of children with cancer and evidence-based, positive psychology interventions to promote the subjective well-being of this population. Thus, this study sought to address this gap in the literature …


An Evaluation Of Check-In/Check-Out For Children With Emotional And Behavioral Disorders, Norma E. Guillen Jun 2025

An Evaluation Of Check-In/Check-Out For Children With Emotional And Behavioral Disorders, Norma E. Guillen

USF Tampa Graduate Theses and Dissertations

Children with emotional and behavioral disorders (EBD) often display disruptive behavior that can hinder their learning and negatively affect the classroom environment. Check-in/Check-Out (CICO) is a Tier-2, evidence-based intervention designed to support children who have difficulty engaging in classroom activities and are at-risk of developing more severe challenging behavior. The primary goal of the intervention is to prevent the escalation of these behaviors and reduce the need for more intensive individualized interventions. However, limited research exists on the effectiveness of CICO for children with emotional and behavioral disorders (EBD). This study examined the effects of CICO on improving on-task behavior …


Sea Turtle Nesting On Nourished Beaches With Different Construction Designs: A Case Study In Southeast Florida, Usa., Lara Novalvos Hernandez Jun 2025

Sea Turtle Nesting On Nourished Beaches With Different Construction Designs: A Case Study In Southeast Florida, Usa., Lara Novalvos Hernandez

USF Tampa Graduate Theses and Dissertations

This study examines the influences of different beach nourishment designs and subsequent post-nourishment profile adjustments on loggerhead (Caretta caretta) and green (Chelonia mydas) sea turtles nest survival and reproductive success. Data on time-series post-nourishment beach-profile changes, positions and elevations of turtle tracks and nest/false-crawl apices, and sea turtle nest hatch/emergence success were collected on five high density nesting beaches along the east coast of Florida: Melbourne Beach, Jensen Beach, Jupiter Island Beach, Juno Beach, and South Hutchinson Island Beach. The field data collection was conducted in 2018, 2019, 2021, and 2022 with the main goal of documenting and comparing turtle …


Behavior And Land Use Of Eastern Gray Squirrels In Urban And Suburban Environments, Laura F. Engel Jun 2025

Behavior And Land Use Of Eastern Gray Squirrels In Urban And Suburban Environments, Laura F. Engel

USF Tampa Graduate Theses and Dissertations

Urbanization has significantly altered natural habitats, impacting wildlife behavior and distribution. This study examines the behavior and land use of eastern gray squirrels (Sciurus carolinensis) in urban and suburban environments at the University of South Florida. Using a combination of point count surveys and time-activity budgets, squirrel presence was assessed in relation to tree genera, nest locations, human activity, and infrastructure. Results indicate a significant association between squirrel presence and tree genera, with a preference for Quercus species, as well as a strong positive correlation between human infrastructure and squirrel presence. However, no significant relationship was found between human presence …


Bridging Virtual Robots And Physical Tasks Via Augmented Reality, Xiangfei Kong Jun 2025

Bridging Virtual Robots And Physical Tasks Via Augmented Reality, Xiangfei Kong

USF Tampa Graduate Theses and Dissertations

Entry to human-robot interaction research, e.g., conducting empirical experiments, faces a significant economic barrier due to the high cost of physical robots, ranging from thousands to tens of thousands. This cost issue also severely limits the field’s ability to replicate user studies and reproduce the results to verify their reliability, thus offering more confidence to incorporate these findings. Although virtual reality (VR) user studies present a potential solution, it is unclear whether we can confidently transfer the findings to physical robots and physical environments because VR isolates both the physical robot and the physical world where robots operate. To address …


Sustaining The Spark: Professional Learning For The Seasoned Principal, Jennifer C. Mccrystal Jun 2025

Sustaining The Spark: Professional Learning For The Seasoned Principal, Jennifer C. Mccrystal

USF Tampa Graduate Theses and Dissertations

Principals play a pivotal role in shaping student achievement and supporting teacher success. However, the limited existing research reveals that professional development opportunities for principals, especially seasoned ones, are often uninspiring, inadequately designed, and disconnected from their actual needs. As a result, seasoned principals may face challenges in maintaining motivation, engagement, and continued leadership development. This study addresses this gap by investigating how seasoned principals perceive and value professional learning, focusing specifically on their pinnacle experiences—those they regard as the most impactful and significant throughout their careers.

Using a narrative inquiry approach with an Appreciative Inquiry lens, this study captures …


Embedding-Based Deep Learning Frameworks For Multimodal Oncology Data Integration, Aakash Gireesh Tripathi Jun 2025

Embedding-Based Deep Learning Frameworks For Multimodal Oncology Data Integration, Aakash Gireesh Tripathi

USF Tampa Graduate Theses and Dissertations

This dissertation presents a cohesive set of novel frameworks developed to address critical challenges in oncology data integration, representation learning, and clinical information extraction. The work encompasses four interconnected projects: MINDS (Multimodal Integration of Oncology Data System), HoneyBee (Harmonized ONcologY Biomedical Embedding Encoder), LLM Extraction (Large Language Model-based Extraction from Pathology Reports), and EAGLE (Embedding Analysis for Generalized Learning in Oncology). Together, these systems enable the unification of diverse cancer data modalities—from genomics and clinical records to histopathology images and radiological scans—creating a robust foundation for advanced machine learning applications in precision oncology. By addressing key barriers in data accessibility, …


Adapting And Evaluating A Positive Psychology Intervention For Children With Cancer And Their Families, Camryn Legra Jun 2025

Adapting And Evaluating A Positive Psychology Intervention For Children With Cancer And Their Families, Camryn Legra

USF Tampa Graduate Theses and Dissertations

This study utilized a mixed methods approach in two phases. The first phase entailed adapting an evidence-based positive psychology intervention—the Well-Being Promotion Program (WBPP; Suldo, 2016)— for children with pediatric cancer. The WBPP has mostly been provided to students at public schools, and to the researcher’s knowledge, has never been used for children with pediatric cancer. To make it culturally appropriate for this group of students, adaptations were made by collecting input and recommendations from a sample of two caregivers of children with pediatric cancer who participated in a focus group. A micro-interlocutor analysis (Onwuegbuzie et al., 2009) was completed …


Food For Thought: Binge Planning Cognitions And Behaviors Within An Online Sample Of Adults With Binge-Type Eating Disorders, Rose H. Miller Jun 2025

Food For Thought: Binge Planning Cognitions And Behaviors Within An Online Sample Of Adults With Binge-Type Eating Disorders, Rose H. Miller

USF Tampa Graduate Theses and Dissertations

Research has begun exploring the phenomenon of binge planning, wherein individuals who binge eat do so with forethought, rather than impulsively. What specific thought processes and behaviors comprise binge plans remains unexamined. How, or if, the eating disorder presentations of individuals who plan binges ahead of time differ from those who binge impulsively is also still unknown. The present study sought to explore the thoughts, emotions, and behaviors associated with binge planning, and to identify how the motivations, symptomologies, and personality traits (i.e., impulsivity) differ between binge eaters who do or do not plan their binges. An online study using …


"You Should Not Judge, You Should Understand": The Effects And Perceptions Of An Empathy Embedded Teacher Inquiry Framework, Erica J. Milor Jun 2025

"You Should Not Judge, You Should Understand": The Effects And Perceptions Of An Empathy Embedded Teacher Inquiry Framework, Erica J. Milor

USF Tampa Graduate Theses and Dissertations

A slew of challenges make up the landscape of special education today-from teacher shortages to lack of resources and vast inequities. Teachers must be able to effectively address the diverse needs of students in the midst of the aforementioned challenges at a micro, meso, and macro level. Teacher Inquiry, an iterative problem-solving cycle, is an effective framework for teachers to do so. The purpose of this study was to develop a systematic empathy-embedded problem-solving cycle for special education teachers in order to increase student progress and effective problem-solving in the educational setting, while exploring how teachers say they perceive this …


Using Stomach Content Analysis To Determine The Trophic Ecology Of Omosudis Lowii, A Deep-Sea Predator In The Gulf Of Mexico, Claire De Noyo Jun 2025

Using Stomach Content Analysis To Determine The Trophic Ecology Of Omosudis Lowii, A Deep-Sea Predator In The Gulf Of Mexico, Claire De Noyo

USF Tampa Graduate Theses and Dissertations

Little is known about the feeding dynamics of deep-sea communities, despite their significant ecological importance. Deep-pelagic communities contribute to marine biodiversity and ecosystem stability while directly offsetting climate change via carbon sequestration. Omosudis lowii is an understudied, deep-sea fish found in temperate and tropical waters worldwide, including the Gulf of Mexico. Omosudis lowii have large jaws and distensible stomachs, allowing them to capture prey items larger than their body size. The present seminal study used stomach content analysis to quantitatively describe the O. lowii trophic ecology, providing baseline data regarding diet composition, feeding selectivity, and factors that impact prey selection. …


Branching Corals Modulate Their Hydrodynamic Environment, Enhancing Capture Rates Of Evasive Prey, Kelsey Daniels Jun 2025

Branching Corals Modulate Their Hydrodynamic Environment, Enhancing Capture Rates Of Evasive Prey, Kelsey Daniels

USF Tampa Graduate Theses and Dissertations

Reef-building corals obtain nutrients through two primary means: autotrophy (via mutualism with photosynthetic zooxanthellae) and heterotrophy (via feeding). The latter form of resource acquisition is understudied and many aspects of predator-prey interactions between coral and naturally occurring prey species remain unexplored. In this thesis, I elucidate the role of branching coral morphology in shaping the colony’s local hydrodynamic environment and describe how this environment impacts prey capture, particularly among evasive and hydrodynamically sensitive, but highly abundant prey such as copepods. I used acrylic cylinders of three sizes in aquaria to model the structure of coral branches across the range of …


Branding In The Spotlight: The Impact Of Name, Image, And Likeness (Nil) On Athlete Brand Image In College Athletics, Timothy Jeremiah Ervin Ii Jun 2025

Branding In The Spotlight: The Impact Of Name, Image, And Likeness (Nil) On Athlete Brand Image In College Athletics, Timothy Jeremiah Ervin Ii

USF Tampa Graduate Theses and Dissertations

This qualitative thesis explores the impact of Name, Image, and Likeness (NIL) on athlete brand image within college athletics, with a focus on the lived experiences of men and women college basketball players. Through in-depth, semi-structured interviews with eight Division I athletes, the study examines how NIL has influenced personal branding, identity construction, and public visibility. Guided by brand identity theory and athlete brand image, and analyzed using Braun and Clarke’s thematic analysis, four central themes emerged: athlete (brand) empowerment, legacy through authenticity, navigating influence, image, and objectification, and economic viability and opportunity. Additionally, the concept of self-presentation emerged as …


Identification Of Host Nuclear Factors Exploited By Kshv Lana To Maintain Latency, Anandita Ghosh Jun 2025

Identification Of Host Nuclear Factors Exploited By Kshv Lana To Maintain Latency, Anandita Ghosh

USF Tampa Graduate Theses and Dissertations

Kaposi’s Sarcoma Associated Herpes Virus (KSHV or HHV-8) is a γ-herpesvirus implicated in multiple lymphoproliferative human cancers and immune dysregulatory diseases. Like other herpesviruses, KSHV has a biphasic mode of infection primarily orchestrated by two viral proteins: the Latency-Associated Nuclear Antigen (LANA), which promotes viral persistence through latency, and the Replication and Transcription Activator (RTA), which triggers lytic reactivation. During latency, the KSHV genome exists as a highly heterochromatinized, extrachromosomal episome in the nucleus, which can be reverted to euchromatin in response to certain stimuli, like stress. KSHV has evolved to exploit numerous host proteins to orchestrate its lifecycle, especially …