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Articles 151 - 180 of 1223

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Compositions And Methods For Modulating The Endothelial Barrier, Jerome William Breslin, Zeinab Yehia Khalil Motawe Aug 2023

Compositions And Methods For Modulating The Endothelial Barrier, Jerome William Breslin, Zeinab Yehia Khalil Motawe

USF Patents

Disclosed are compositions and methods for modulating endothelial barrier function.

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Commencement Convocation Program, Usf, August 8, 2023, University Of South Florida Aug 2023

Commencement Convocation Program, Usf, August 8, 2023, University Of South Florida

USF Graduation and Convocation Programs

King O'Neal Scholars - Emma Grace Atherton, Alisa Bakieva, Ginelle Renae Lauryn Brown, Tatyana Soribel Butler, Carter E. Casko, Carli Lilibeth Cohoon, Sarah Lou Shalom Dasent Shuler, Carlos Manuel Figueroa Palomino, Lanette Gonzalez-Lewis, Grace Angelique Heeke, Daniel Thomas Kortenhaus, Emily Margaret Logan, Makayla Long, Abigail Clariece McCurter, Elijah Callaway Mceuen, Sofia Elizabeth Mejia-Naccarato, Rachel Yvonne Stanton, Edward B. Williams, and Parisa Yazdankhah Kenary; Global Citizens Award - Sarah Bagnasco, Sydney Black, Carly Burton, Gladys D. Cantu, Sara Chaj, Lauren Flannery, Emily Hernandez, Anagha Hesaraghatta, Faith Pinamang, Katie Sarnelli, Natalie Spanhake, Kenya A. Sanchez Torres, and Neha Vemuri

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Covid-19 And The “Most Magical Place On Earth”: Applying The Idea Model To Theme Park Crisis Messaging, Lakelyn E. Taylor, Gaurav Panse, Carissa Baker, Deanna Sellnow, Timothy Sellnow, Michael Strawser Aug 2023

Covid-19 And The “Most Magical Place On Earth”: Applying The Idea Model To Theme Park Crisis Messaging, Lakelyn E. Taylor, Gaurav Panse, Carissa Baker, Deanna Sellnow, Timothy Sellnow, Michael Strawser

University of South Florida (USF) M3 Publishing

The global tourism reaches of Orlando, Florida, and the world’s most visited theme park complex, Walt Disney World, provide a unique context for studying global communication in a tourism setting through the crisis messaging efforts. This study explores the reopening of Walt Disney World and subsequent messaging, specifically from a risk and crisis perspective, using the IDEA model to categorize Disney COVID-19 messages. Using a qualitative, etic approach via a codebook based on the IDEA model, the study results determined whether pandemic messages and mentions (the study’s unit of analysis) addressed internalization, explanation, or action.

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Restrictions Are Lifted: The Effect Of Risk Perception Of Covid-19 On Future Travel Intentions Of Dutch Travellers, Rami K. Isaac Aug 2023

Restrictions Are Lifted: The Effect Of Risk Perception Of Covid-19 On Future Travel Intentions Of Dutch Travellers, Rami K. Isaac

Journal of Global Hospitality and Tourism

This study aims to understand better the psychological impact of COVID-19, the risk perception, travel and destination risks of Dutch travellers and their intention to travel when travel restrictions due to COVID-19 are lifted. This study takes a step toward closing the gap in the literature as it provides new insights into the risk perceptions regarding COVID-19 and the travel intentions of Dutch travellers now that travel restrictions are lifted. This study employed a quantitative approach to market research. Questionnaire research was applied. The questionnaire is created with the web-based survey tool Qualtrics. 343 respondents filled in the questionnaire. The …

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Role Of Short Interspersed Nuclear Elements (Sines) Of Maternally Imprinted Microrna Clusters In Hemochorial Placental Antiviral Immunity, Ishani Wickramage Jul 2023

Role Of Short Interspersed Nuclear Elements (Sines) Of Maternally Imprinted Microrna Clusters In Hemochorial Placental Antiviral Immunity, Ishani Wickramage

USF Tampa Graduate Theses and Dissertations

The evolution of hemochorial placentas in which the fetal trophoblast is bathed in maternal blood has vastly improved fetal development and survival in primates and rodents, due to the enhanced efficiency of nutrient, gas and waste exchange between the mother and the fetus. However, the extensive contact between the fetal tissues and maternal blood in these placentas also poses an increased risk of vertical transmission of pathogens such as viruses from the mother to the fetus. In response to this selection pressure, hemochorial placentas have evolved robust defense mechanisms to protect the immunologically naive fetus. Unlike somatic cells that require …

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Synthesis Of Tools For The Investigation And Treatment Of Infectious Diseases, Grant Lawrence Jul 2023

Synthesis Of Tools For The Investigation And Treatment Of Infectious Diseases, Grant Lawrence

USF Tampa Graduate Theses and Dissertations

Modern medicine’s ability to treat a wide array of diseases is due mainly to the development of small-molecule drug discovery. Thousands of years of traditional medicines have been dwarfed in less than a hundred years. In addition, drug discovery has becoming a more consistent process with the introduction of the clinical trials process as well.Plasmodium is a genus of tropical parasites that have the potential to wreak havoc on billions of people globally. Current methods of drug discovery aimed at defeating these parasites require expensive assays that use radioactive material. By using an alkyne-labeled agent instead of a tritium-labeled agent, …

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How Post-Immunization Covid-19 Context Affected Residents’ Evacuation Behavior During Hurricane Ida, Amy Polen, Jennifer Collins, Elizabeth Dunn, Stephen Murphy, Isabelle Jernigan, Killian Mcsweeney, Yi Jie Zhu Jul 2023

How Post-Immunization Covid-19 Context Affected Residents’ Evacuation Behavior During Hurricane Ida, Amy Polen, Jennifer Collins, Elizabeth Dunn, Stephen Murphy, Isabelle Jernigan, Killian Mcsweeney, Yi Jie Zhu

School of Geosciences Faculty and Staff Publications

Since the onset of the COVID-19 pandemic, decision-making during disasters fundamentally changed to accommodate the combined risks of hurricanes and infectious diseases. Prior research conducted in 2020 by Collins et al. examined how individuals changed their intended evacuation decision-making during the pandemic or their actual evacuation decisions during Hurricanes Laura and Sally. Hurricane Ida provided further data on evacuation decision-making when vaccinations and masks were widely available. A digital survey was disseminated to individuals affected by Hurricane Ida in 2021. Respondents provided information about their actual evacuation choices and perceptions of public shelters and COVID-19 risks. In comparison with the …

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Desperate And Opportunistic: Cbrn Terrorists And Civilian Radiological Material, Oliver Mihell-Hale Jul 2023

Desperate And Opportunistic: Cbrn Terrorists And Civilian Radiological Material, Oliver Mihell-Hale

Journal of Strategic Security

Chemical, Biological, Radiological, and Nuclear (CBRN) terrorism has long been a threat that has concerned policy makers. This paper highlights the factors which determine when a group is likely to use CBRN weapons given the numerous constraints on their use. A group which is desperate, small, and innovative is most likely to resort to their use as the taboos which constrain groups under normal circumstances become an incentive. These characteristics also determine what type of CBRN weapon will be used, a basic radiological weapon. A radiological weapon is relatively easy to develop compared to other options, and the material for …

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Withaferin A And Immune Checkpoint Blocker Therapy For The Treatment Of Non-Small Cell Lung Cancer, Roukiah Khalil Jun 2023

Withaferin A And Immune Checkpoint Blocker Therapy For The Treatment Of Non-Small Cell Lung Cancer, Roukiah Khalil

USF Tampa Graduate Theses and Dissertations

Lung cancer is the first cause of cancer-related deaths in both men and women with an overall five-year survival rate of 28%. Although immune checkpoint blockers (ICBs) are currently FDA-approved for the treatment of non-small cell lung cancer (NSCLC), only 17-20% of patients achieve durable responses by the induction of immunologic memory. The lack of response in most patients can be attributed to the tumor-intrinsic or tumor-extrinsic immune resistance mechanisms. A biomarker of importance is the Programmed Death Ligand-1 (PD-L1), as higher PD-L1 expression is usually associated with a better response to ICBs. Although studies have attempted to combine ICBs …

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Acetate-Encapsulated Linolenic Acid Liposomes Reduce Sars-Cov-2 And Rsv Infection, Andrew R. Mcgill Jun 2023

Acetate-Encapsulated Linolenic Acid Liposomes Reduce Sars-Cov-2 And Rsv Infection, Andrew R. Mcgill

USF Tampa Graduate Theses and Dissertations

Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is an ongoing pandemic-endemic. In the United States, it remains the third leading cause of death in 2022. SARS-CoV-2, an RNA virus, has a genome prone to rapid mutation, generating variant species capable of resisting therapies and vaccination efforts. However, it has been estimated that more than 40% of SARS-CoV-2 infections may be asymptomatic, which calls into question any biological differences between the asymptomatic and afflicted groups. Additionally, Respiratory Syncytial Virus (RSV) is the most significant cause of bronchiolitis and asthma in neonates, with an increasing burden on the …

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Evaluation Of The Humoral Immune Responses To Plasmodium Vivax Circumsporozoite Protein (Csp)-Based Pre-Erythrocytic Vaccine Candidates, Jack Esquenazi Jun 2023

Evaluation Of The Humoral Immune Responses To Plasmodium Vivax Circumsporozoite Protein (Csp)-Based Pre-Erythrocytic Vaccine Candidates, Jack Esquenazi

USF Tampa Graduate Theses and Dissertations

Malaria, caused by the apicomplexan Plasmodium spp. , is a major public health issue that impacts over one-third of the world’s population ,with Plasmodium vivax accounting for over 130 million clinical cases annually. The circumsporozoite protein (CSP) is the most abundant molecule on the surface of Plasmodium sporozoites and is considered a leading pre-erythrocytic stage vaccine candidate. CSP is essential for sporozoite maturation, migration, and invasion. Anti-CSP antibodies interrupt sporozoite migration and infection of hepatocytes thus reducing liver-stage burden. P. vivax CSP is composed of three subdomains: a highly polymorphic immunodominant central repeat region (CRR), conserved N-terminal ,and C-terminal subdomains. …

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Development Of A Ddpcr Multiplex To Measure The Immune Response To Borrelia Burgdorferi., Kailey Marie Mccain Jun 2023

Development Of A Ddpcr Multiplex To Measure The Immune Response To Borrelia Burgdorferi., Kailey Marie Mccain

USF Tampa Graduate Theses and Dissertations

Zoonotic diseases account for a significant proportion of emerging infectious diseases (EIDs), with their dynamics being heavily influenced by the environment. While the effects of the environment on population-level disease dynamics have been extensively studied, there is limited research investigating the impact of the environment on individual-level disease susceptibility and transmission. This study aims to fill this gap by creating a tool to examine the variation in immune response to Borrelia burgdorferi, the causative agent of Lyme Disease, in two competent host species, Peromyscus leucopus and Peromyscus maniculatus. Two triplex droplet digital polymerase chain reaction (ddPCR) assays were developed to …

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The Effects Of Integral And Incidental Emotions On The Perceived Risk Of Gun Violence, Gloria Laugalis Jun 2023

The Effects Of Integral And Incidental Emotions On The Perceived Risk Of Gun Violence, Gloria Laugalis

USF Tampa Graduate Theses and Dissertations

Fearful people are pessimistic when it comes to risk judgments and angry people areoptimistic in their risk judgments (Lerner & Keltner, 2000; 2001). Since this has been supported in studies regarding both incidental and integral emotions, the findings from incidental studies have been broadly generalized to answer research questions regarding integral emotions. This generalization was challenged when Ferrer and Ellis (2021) recently found differing effects of incidental and integral emotions of fear and anger. In this study, we examine the effects of these emotions, both incidental and integral to the target risk, on risk perception to help determine if incidental …

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Preliminary Characterization And Functional Validation Of Pre-Erythrocytic Vaccine Candidates For The Malaria Parasite Plasmodium Vivax, Justin Lee Nicholas Iii Jun 2023

Preliminary Characterization And Functional Validation Of Pre-Erythrocytic Vaccine Candidates For The Malaria Parasite Plasmodium Vivax, Justin Lee Nicholas Iii

USF Tampa Graduate Theses and Dissertations

RTS,S/AS01, vaccine targeting malaria caused by Plasmodium falciparum, used in moderate to high malaria transmission, provides hope for pre-erythrocytic (PE) subunit malaria vaccine development. Despite this vaccine advance, efforts to develop an efficacious vaccine against the neglected parasite Plasmodium vivax have lagged. In addition, there exists a gap in our understanding of PE antigens that can induce broadly-neutralizing antibodies. In this dissertation, we provide the preliminary characterization of vaccine candidates targeting the PE of P. vivax. Through transcriptomic profiling data and a target product profile, we identified critical P. vivax antigens (SSP3, SPECT-1, and M2-MAEBL) that can potentially be targets …

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A Review Of Farmers/Herders Clashes In Nigerian Environment: Consequences And The Way Forward, Timothy O. Ogunbode, Iyanu-Oluwa A. Ayodele, Victor O. Oyebamiji, Oluwatobi O. Faboro Jun 2023

A Review Of Farmers/Herders Clashes In Nigerian Environment: Consequences And The Way Forward, Timothy O. Ogunbode, Iyanu-Oluwa A. Ayodele, Victor O. Oyebamiji, Oluwatobi O. Faboro

Journal of African Conflicts and Peace Studies

A peaceful environment is a necessity for meaningful growth and development in human society. This review was thus, carried out to examine both immediate and remote causes of Fulani herdsmen/local farmers’ crises in Nigeria, its consequences and the probable way forward. The review which involved searching for both online and offline information on the theoretical basis for the crises and, also the interview of the stakeholders for hands-on information. The crises which was noted to have dated back to 1960s has resulted into loss of lives and property. Apart from this, many homes have been displaced and means of livelihood …

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Automated Approaches To Enable Innovative Civic Applications From Citizen Generated Imagery, Hye Seon Yi May 2023

Automated Approaches To Enable Innovative Civic Applications From Citizen Generated Imagery, Hye Seon Yi

USF Tampa Graduate Theses and Dissertations

Smart governance is an area, that is increasingly becoming important, not only in advanced countries, but all across the globe. Thanks to global scale network connectivity, permeance of smart-devices of various form-factors, and overall improvement in digital literary, we are now seeing "smartness" everywhere, or if not, the general public is expecting the same. Ultimately, the goal of smart governance is to facilitate state-of-the-art technologies to improve citizens’ lives. With the ubiquity of smart phone technologies today, citizens more readily participate in collaboration with public officials for improved quality of life and their communities. By utilizing optimal tools, public officials …

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Data-Driven Learning Algorithm Via Densely-Defined Multiplication Operators And Occupation Kernels., John Kyei Mar 2023

Data-Driven Learning Algorithm Via Densely-Defined Multiplication Operators And Occupation Kernels., John Kyei

USF Tampa Graduate Theses and Dissertations

Consider a nonautonomous nonlinear evolution $\dot{x}=f(x,t,\mu)$, where the vector $x(t) \in \mathbb{R}^n$ represents the state of the dynamical system at time $t$, $\mu$ contains system parameters, and $f(\cdot)$ represents a dynamic constraint. In most practical applications, the nonlinear dynamic constraint $f$ is unknown analytically. The problem of approximating $f$ directly from data measurements generated by the system is a main goal of this manuscript. In the postulates of the Nonlinear Autoregressive (NAR) framework, we show that the problem of approximating $f$ can be studied through symbols of densely defined multiplication operators over a Reproducing Kernel Hilbert Spaces (RKHS). In this …

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A Forward Genetic Screen Identifies Genes Involved In Gametocyte Development Of The Human Malaria Parasite Plasmodium Falciparum., Jyotsna Chawla Mar 2023

A Forward Genetic Screen Identifies Genes Involved In Gametocyte Development Of The Human Malaria Parasite Plasmodium Falciparum., Jyotsna Chawla

USF Tampa Graduate Theses and Dissertations

Transmission of the deadly malaria parasite Plasmodium falciparum from human to mosquito is achieved by specialized intraerythrocytic sexual forms called gametocytes. Circulating in the vertebrate host, relatively few intraerythrocytic gametocytes are picked up during a bloodmeal to continue sexual development in the mosquito vector. Human-to-vector transmission thus represents an infection bottleneck in the parasite's life cycle for therapeutic interventions to prevent malaria. Though the crucial regulatory mechanisms leading to gametocyte commitment have recently come to light, networks of genes that control sexual development remain to be elucidated. Here, we report a forward genetic approach to identify genes associated with gametocyte …

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Partial Characterization Of Plasmodium Falciparum Genes Implicated In Altered Artemisinin Stress Response, Caroline F. Simmons Mar 2023

Partial Characterization Of Plasmodium Falciparum Genes Implicated In Altered Artemisinin Stress Response, Caroline F. Simmons

USF Tampa Graduate Theses and Dissertations

Malaria is a parasitic illness caused by the Plasmodium spp., with an estimated 247 million malaria cases reported in 2021 across 84 endemic countries. Treatment of the deadliest malaria parasite, P. falciparum, relies on artemisinin combination therapies (ACTs). However, while ACTs have greatly decreased malaria mortality, this progress is threatened due to artemisinin (ART) partial resistance and ACT failure in Southeast Asia and Sub-Saharan Africa. SNPs to the Kelch13 (K13) gene are a well-characterized marker for ART resistance. However, increasing evidence that resistance to ART mediated by genes not related to K13 SNPs prompts the need to characterize other novel …

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Histone Deacetylase 8 Is A Novel Therapeutic Target For Mantle Cell Lymphoma And Preserves Natural Killer Cell Cytotoxic Function, January M. Watters Mar 2023

Histone Deacetylase 8 Is A Novel Therapeutic Target For Mantle Cell Lymphoma And Preserves Natural Killer Cell Cytotoxic Function, January M. Watters

USF Tampa Graduate Theses and Dissertations

This study demonstrates for the first time that HDAC8 function is critical for MCL survival, and abrogating its activity in human primary NK cells does not interfere with NK IgG antibody directed ADCC therapies ex vivo. Human NK cells, isolated from healthy donors, are highly resistant to HDAC8 inhibitor treatment with PCI-34051. Even at the highest concentration, 20uM, no toxicity was observed. Conversely, MCL cell lines representative of the aggressive MCL subtype, classical MCL, were especially sensitive to PCI-34051, an HDAC8 selective inhibitor, treatment. Blocking HDAC8 activity and/or abrogating expression through shRNA silencing induced significant DNA damage, hyperacetylation of SMC3, …

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Natural Disasters And Human Capital: Empirical Evidence From Indonesia, Lei Lv Mar 2023

Natural Disasters And Human Capital: Empirical Evidence From Indonesia, Lei Lv

USF Tampa Graduate Theses and Dissertations

In developing countries, natural disasters could destroy physical capital and adversely affect human capital accumulation by disrupting individual decisions. Such decisions play a critical role in determining individuals' human capital accumulation process and have a lifelong effect on their happiness and economic prosperity. To better understand how natural disasters affect human capital in developing countries, this dissertation uses the earthquakes in Indonesia as a natural experiment to study how this earthquake affects health, child marriage, and education. For the first chapter, I study how the 2006 Yogyakarta Earthquake a affects water-related acute disease symptomsin the short and long run. By …

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Spatial Pattern And Environmental And Social Factors Of Monkeypox In The Contiguous United States, Linbo Han Mar 2023

Spatial Pattern And Environmental And Social Factors Of Monkeypox In The Contiguous United States, Linbo Han

USF Tampa Graduate Theses and Dissertations

Monkeypox is a rare viral disease that is usually transmitted to humans through contact with infected animals, such as rodents or primates. Although its symptoms are similar to those of smallpox, monkeypox is generally less severe and rarely fatal. In recent years, however, there has been an uptick in the number of reported cases, with a large outbreak occurring in several parts of the world in May 2022. This has raised concerns among public health officials and researchers, who are working to better understand the factors that contribute to the spread of the disease. One promising approach to studying the …

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Diatom Diversity And Functional Groups In 72 Florida Lakes: Assessing Ecological Changes For Improved Protection And Management, Francesca M. Lauterman Mar 2023

Diatom Diversity And Functional Groups In 72 Florida Lakes: Assessing Ecological Changes For Improved Protection And Management, Francesca M. Lauterman

USF Tampa Graduate Theses and Dissertations

Florida lakes are diverse ecosystems and are an important part of the state's biodiversity and ecosystem services. As human population and development increase across the state, many lakes have been documented as nutrient impaired and are unable to maintain essential ecological functions. In this study, diatom diversity and functional groups in 72 Florida lakes were assessed for their relationships with associated water-quality data. Common alpha diversity indices, including Shannon-Weiner Index, the Gini-Simpson Index, and Hill’s numbers were utilized to measure trends in diatom communities, while the relationships between diatom lifeform characteristics and environmental data were explored using multivariate methods and …

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Of Mētis And Cuttlefish: Employing Collective Mētis As A Theoretical Framework For Marginalized Communities, Justiss Wilder Burry Mar 2023

Of Mētis And Cuttlefish: Employing Collective Mētis As A Theoretical Framework For Marginalized Communities, Justiss Wilder Burry

USF Tampa Graduate Theses and Dissertations

This LGBTQ+ rhetoric of health and medicine (RHM) community-based research explores the ways community members and queer community participants communicate about potential intimate partner selection in Central Florida. The dissertation introduces the theoretical framework of “collective mētis” as a way to analyze and discuss community communication against Florida’s required HIV disclosure laws that attempt to medicalize this and control this community’s intimate partner selection. Research questions include: 1) How do people in counterpublic enclaves (Chávez, 2011) communicate their potential intimate partner desires to others in the community including the types of disclosures they express and negotiate, and how? 2) How …

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Covid-19 In Bangladesh: A Systematic Review Of The Literature From March 2020 To March 2021, Md. Shahin Parvez, Md. Al-Mamun, Md. Anisur Rahaman, Sheuli Akter, Kaniz Fatema, Halimatus Sadia, Anika Intesar Mar 2023

Covid-19 In Bangladesh: A Systematic Review Of The Literature From March 2020 To March 2021, Md. Shahin Parvez, Md. Al-Mamun, Md. Anisur Rahaman, Sheuli Akter, Kaniz Fatema, Halimatus Sadia, Anika Intesar

Journal of Global Business Insights

COVID-19 has undoubtedly absorbed the global public's angst. It has quickly disturbed global life and will have long-term and short-term consequences on several sectors. This comprehensive review study's goal is to discover what research has been done in a year since the beginning of coronavirus in Bangladesh. Consequently, the current study examined the pervasiveness and affiliation of social and economic issues, health and psychological issues and individual perceptions, key challenges, strategies and policy systems, public health, online education, agriculture and food security, criminal activities related to outbreaks, Rohingya refugee issues, and the quality of domestic violence behaviors. The review used …

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Gauging The Role Of Personality In Risk Perception During A Health Crisis And Its Impact On Tourist Consumption Behaviour, Akshita Agarwal Feb 2023

Gauging The Role Of Personality In Risk Perception During A Health Crisis And Its Impact On Tourist Consumption Behaviour, Akshita Agarwal

Journal of Sustainability and Resilience

This study examines the influence of the tourist personality and the use of technology on the traveler behavior and the risk perception about travelling. The purpose of this study is to investigate the link between personality, risk perception, and travel behavior among French travelers. An online survey was conducted using a sample of 422 responses to examine individual variations in risk perception during a health crisis and their influence on travel behavior. The study was carried out using PLS-SEM, and a model was proposed that considered the substantial Average Variance Extracted (AVE) and Composite Reliability test findings. The findings demonstrated …

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Comparing Potential And Repeat Chinese Guests' Cruise Travel Intentions In Post-Covid-19, Lan Lu, Jinlin Zhao, Miranda Kitterlin Feb 2023

Comparing Potential And Repeat Chinese Guests' Cruise Travel Intentions In Post-Covid-19, Lan Lu, Jinlin Zhao, Miranda Kitterlin

Journal of Global Hospitality and Tourism

This study extended the theory of reasoned action (TRA) by including cruise involvement, safety protocols, and trust (stimulus-organism-response paradigm), and risk perception (the prospect theory), developing a theoretical framework to explore and compare Chinese repeat and potential guests' travel intentions, thus making great efforts to rebuilding consumer confidence and recover operation at this stage of the post-COVID-19. The results show that guests' intentions were positively influenced by their perceptions of safety protocols, trust, attitude, subjective norms, and cruise involvement, respectively. In contrast with previous studies, present results showed that perceived risk has a significant positive effect on the intention of …

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Communication During Covid-19 Crisis: A Case Of Hotels In Turkey, Ayse Selin Dulger, Ayse Bas Collins, Aysegul Gunduz Songur, Cihan Cobanoglu Feb 2023

Communication During Covid-19 Crisis: A Case Of Hotels In Turkey, Ayse Selin Dulger, Ayse Bas Collins, Aysegul Gunduz Songur, Cihan Cobanoglu

Journal of Global Hospitality and Tourism

During the COVID-19 pandemic, which has spread all over the world, the importance of communication in terms of knowledge sharing has increased even more in the tourism sector, as in all sectors. Each hotel business has benefited from various communication tools in the pandemic crisis. The aim of this study is to provide an understanding of the crisis communication strategy tackled by the hotels in Turkey during this unprecedented period, via both conventional and internet based public relations and communication platforms within the framework of crisis communication management. For this purpose, in-depth interviews were conducted with 25 hotel managers in …

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Utilizing Neoantigen-Specific Cd4* T Cells And Immune Checkpoint Modulation To Advance Adoptive Cell Therapy With Tumor-Infiltrating Lymphocytes For Metastatic Melanoma Patients, Maclean Scott Hall Jan 2023

Utilizing Neoantigen-Specific Cd4* T Cells And Immune Checkpoint Modulation To Advance Adoptive Cell Therapy With Tumor-Infiltrating Lymphocytes For Metastatic Melanoma Patients, Maclean Scott Hall

USF Tampa Graduate Theses and Dissertations

Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) is a promising immunotherapeutic approach for patients with advanced solid tumors. Metastatic melanoma is a tumor type amenable to immunotherapy in part due to the presence of antigen-specific TIL. These T cells can be activated and expanded for ACT, which has resulted in relatively high rates of clinical responses. While numerous advances have been made, the inclusion of neoantigen-specific CD4+ T cells within TIL infusion products remains underexplored and therefore offers a significant opportunity for progress. Similarly, immune checkpoint inhibitors, specifically PD-1 blocking antibodies, augment antitumor immunity and may improve the outcomes …

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The Covid-19 Pandemic As A Catalyst For Integrated Global Mental Healthcare And Tuberculosis Care, Alexander L. Chu, Aneeta Pasha, Carmen Contreras, Leonid Lecca, Annika C. Sweetland, Jerome T. Galea Jan 2023

The Covid-19 Pandemic As A Catalyst For Integrated Global Mental Healthcare And Tuberculosis Care, Alexander L. Chu, Aneeta Pasha, Carmen Contreras, Leonid Lecca, Annika C. Sweetland, Jerome T. Galea

Social Work Faculty Publications

Mental disorders are common among persons with tuberculosis (TB), and the COVID-19 pandemic has only amplified the mental and physical health consequences of this deadly synergy. Here, we call to attention the immense vulnerability of people with TB to mental disorders during the pandemic and highlight the unique challenges and opportunities that the pandemic brings to the future integration of global TB and mental healthcare. We argue that the pandemic era is an ideal period to accelerate this integration and we provide research and policy recommendations to actualise this urgent need.

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