Digital Commons Network^™

Infectious Complications In Adult Leukemic Patients With Prolonged Neutropenia Undergoing Induction Chemotherapy, Vidhya Sabapathy, Olga Klinkova, Joseph Balbona, John Greene

Internal Medicine Faculty Publications

Background: Induction chemotherapy in patients with the diagnosis of acute leukemia is associated with a high incidence of infectious complications. While prior studies provide information regarding infectious complications in this patient population, more research is needed to evaluate infection complications in a subgroup of leukemic patients with prolonged neutropenia who often require repeat induction chemotherapy.

Methods: This was a retrospective analysis of 61 patients ages 18–85, between January 1, 2010 and March 14, 2018 who were diagnosed and being treated for acute leukemia. All selected patients experienced severe neutropenia (defined as absolute neutrophil count <500/μL) for ≥7 days. 33 patients underwent their first induction chemotherapy while 28 patients underwent repeat induction chemotherapy. Patient characteristics and infectious complications were examined. Analysis was performed to further study blood stream infections in this patient population.

Results: Sixty-one patients, mean age of …

Comparing Trends And Outcomes Among Hiv-Infected Vs. Hiv Uninfected Patients With Tuberculosis: A 5-Year Experience Within The Florida Department Of Health In Hillsborough County, Shylah M. Moore-Pardo, Anteneh Addisu, Tea Reljic, Sadaf Aslam, Beata Casanas

Internal Medicine Faculty Publications

Background: Although the rate of tuberculosis (TB) has significantly declined in the United States, elimination has plateaued. Florida is one of the states with the greatest number of cases. The majority of cases occur in foreign-born individuals. Human immunodeficiency virus (HIV) is also a major contributor. HIV-TB coinfection leads to reciprocal interactions with significant clinical impact. We aim to compare the risk factors, clinical findings, and outcomes among HIV-infected vs. HIV uninfected patients.

Methods: A retrospective cohort study of TB cases over a 5 year period (2012–2017) was conducted. All patients with HIV co-infection with age- and gender-matched HIV negative …

Demographic Characteristics And Management Of Uninsured Patients With A History Of Melanoma, Noura Ayoubi, Abu-Sayeef Mirza, Mohammad Ayoub, Justin Swanson

Internal Medicine Faculty Publications

Aims and Objectives: Patients diagnosed with malignant melanoma often undergo regular follow-up care and skin checks to reduce the likelihood of recurrence. Yearly exams are more inconsistent and likely to be missed due to a lack of healthcare access and resources among the uninsured population. This study determined demographic characteristics of uninsured patients with a history of malignant melanoma. Follow-up was assessed in order to improve and ensure the highest quality of long-term care.

Methods: Demographics and chronic disease diagnoses were extracted from 8,857 patients managed at eight free-clinics from the Tampa Bay Area during 2016 and 2017. Patients diagnosed …

Predictors Of Recurrent Infective Endocarditis In Intravenous Drug Users, Kullatham Kongpakpaisarn, Sadaf Aslam, Musaab Tariq, Rahul Mhaskar, Doosup Shin, Chandrashekar Bohra, Charurut Somboonwit

Internal Medicine Faculty Publications

Background: Caring for hospitalized patients with infective endocarditis (IE) can be challenging due to the nature of the disease and its complications, underlying medical and psychiatric problems, socioeconomic status and environmental factors.Some of these patients develop recurrent IE after the first episode treated. On-going intravenous (IV) drug use after hospital discharge is the highest predictive factor for recurrent IE. Besides IV drug use, there are limited data of other contributing factors to recurrent IE. Those factors may be modifiable during the first hospitalization to reduce the incidence of recurrent IE.

Methods: A retrospective cohort study was conducted at a large …

Health Care Utilization And Mortality Associated With Heart Failure-Related Admissions Among Cancer Patients, Avirup Guha, Amit Kumar Dey, Merna Armanious, Katherine Dodd, Janice Bonsu, Hani Jneid, William Abraham, Michael G. Fradley, Daniel Addison

Internal Medicine Faculty Publications

Aims: Heart failure (HF) outcomes continue to improve with widespread use of new therapies. Concurrently, cancer survival has dramatically improved. Yet whether cancer patients share similar strategies and outcomes of inpatient HF treatment to those without HF is unknown. We sought to assess the contemporary impacts of cancer on inpatient HF outcomes over time.

Methods and results: The retrospective National Inpatient Sample (2003–15) and National Readmissions Database (2013–14) registries were queried for adults admitted for HF and stratified for cancer status, excluding cases of metastatic disease. Temporal trends in HF admissions, hospital charge rates, length of hospitalization, HF-related procedure utilization, …

Comparison Between Signature Cytokines Of Nasal Tissues In Subtypes Of Chronic Rhinosinusitis, Dong-Kyu Kim, Kyoung Mi Eun, Min-Kyung Kim, Deuktae Cho, Sun A. Han, Sang-Yoon Han, Yuju Seo, Dong-Han Lee, Seong Ho Cho, Dae Woo Kim

Internal Medicine Faculty Publications

Purpose: Endotype in chronic rhinosinusitis (CRS) has been established in the last decade. However, the exact immunologic profile of CRS still has controversy because it has a considerable immunologic heterogeneity. Therefore, we investigated various inflammatory mediators according to different nasal tissues in chronic rhinosinusitis and compared them within the same subject. Methods: We collected uncinate process mucosa (UP) and nasal polyp (NP) tissues from controls, CRS without NP (CRSsNP) and CRS with NP (CRSwNP). Expression levels of 28 inflammatory mediators including T helper (Th) 1, Th2, Th17, proinflammatory cytokines and remodeling markers were determined by multiplex immunoassay and were analyzed …

A Case Report Of Massive Acetaminophen Poisoning Treated With A Novel “Triple Therapy”: N-Acetylcysteine, 4-Methylpyrazole, And Hemodialysis, Emily A. Kiernan, Julie A. Fritzges, Kathryn A. Henry, Kenneth D. Katz

Internal Medicine Faculty Publications

Massive acetaminophen (N-acetyl-p-aminophenol; APAP) ingestion is characterized by a rapid onset of mitochondrial dysfunction, including metabolic acidosis, lactemia, and altered mental status without hepatotoxicity which may not respond to the standard doses of N-acetylcysteine (NAC). A 64-year-old woman without medical history presented comatose after an ingestion of 208 tablets of Tylenol PM™ (APAP 500 mg and diphenhydramine 25 mg). The initial APAP concentration measured 1,017 µg/mL (therapeutic range 10-30 µg/mL), and elevated anion gap metabolic acidosis, lactemia, and 5-oxoprolinemia were detected. High-dose intravenous (IV) NAC, 4-methylpyrazole (4-MP), and hemodialysis (HD) were initiated. She was transferred to a liver …

Assessment Of Emergency Medicine Resident Performance In An Adult Simulation Using A Multisource Feedback Approach, Michael Jong, Nicole Elliott, Michael Nguyen, Terrence Goyke, Steven Johnson, Matthew Cook, Lisa Lindauer, Katie Best, Douglas Gernerd, Louis Morolla, Zachary Matuzsan, Bryan Kane

Internal Medicine Faculty Publications

Introduction: The Accreditation Council for Graduate Medical Education (ACGME) specifically notes multisource feedback (MSF) as a recommended means of resident assessment in the emergency medicine (EM) Milestones. High-fidelity simulation is an environment wherein residents can receive MSF from various types of healthcare professionals. Previously, the Queen’s Simulation Assessment Tool (QSAT) has been validated for faculty to assess residents in five categories: assessment; diagnostic actions; therapeutic actions; interpersonal communication, and overall assessment. We sought to determine whether the QSAT could be used to provide MSF using a standardized simulation case.

Methods: Prospectively after institutional review board approval, residents from a dual …

Ampk: A Balancer Of The Renin–Angiotensin System, Jia Liu, Xuan Li, Qingguo Lu, Di Ren, Xiaodong Sun, Thomas Rousselle, Ji Li, Jiyan Leng

Surgery Faculty Publications

The renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In recent studies, RAS has also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation of several signaling pathways such as proliferation, apoptosis and autophagy, and insulin resistance. AMP-activated protein kinase (AMPK), an essential cellular energy sensor, has also been discovered to be involved in these diseases and cellular pathways. This would imply a connection between the RAS and AMPK. Therefore, this review serves …

Observations On Multi-Generational Interactions In Academic Surgical Practice And Rducation, Fernando A. M. Herbella, Vic Velanovich

Surgery Faculty Publications

No abstract provided.

Extra: A Festschrift In Honor Of James R. King, Lindsay Persohn, Aimee Frier

Teaching and Learning Faculty Publications

No abstract provided.

Are Microclimate Conditions In El Malpais National Monument Caves In New Mexico, Usa Suitable For Pseudogymnoascus Growth?, Terry J. Torres-Cruz, Porras-Alfaro, Nicole A. Caimi

KIP Articles

White-nose syndrome (WNS) is a bat disease caused by the fungal pathogen Pseudogymnoascus destructans, which thrives in cold and very humid environments where bats frequently hibernate. Conidia of Pseudogymnoascus species are often documented on bats prior to the onset of WNS, but characterization of high-risk areas defined by microclimate cave conditions have been lacking. Investigating the occurrence of this fungal genus and appropriate environmental conditions to support P. destructans in southwestern U.S. caves is key to understanding the sites most likely to be impacted by WNS. Microclimate conditions in ten caves at El Malpais (ELMA) National Monument in New Mexico, …

Protocol For Arest: Apixaban For Early Prevention Of Recurrent Embolic Stroke And Hemorrhagic Transformation—A Randomized Controlled Trial Of Early Anticoagulation After Acute Ischemic Stroke In Atrial Fibrillation, David Z. Rose, John N. Meriwether, Michael G. Fradley, Swetha Renati, Ryan C. Martin, Thomas Kasprowicz, Aarti Patel, Maxim Mokin, Ryan Murtagh, Kevin Kip, Andrea C. Bozeman, Tara Mctigue, Nicholas Hilker, Bonnie Kirby, Natasha Wick, Nhi Tran, W. Scott Burgin, Arthur J. Labovitz

Neurology Faculty Publications

Background: Optimal timing to initiate anticoagulation after acute ischemic stroke (AIS) from atrial fibrillation (AF) is currently unknown. Compared to other stroke etiologies, AF typically provokes larger infarct volumes and greater concern of hemorrhagic transformation, so seminal randomized trials waited weeks to months to begin anticoagulation after initial stroke. Subsequent data are limited and non-randomized. Guidelines suggest anticoagulation initiation windows between 3 and 14 days post-stroke, with Class IIa recommendations, and level of evidence B in the USA and C in Europe.

Aims: This open-label, parallel-group, multi-center, randomized controlled trial AREST (Apixaban for Early Prevention of Recurrent Embolic Stroke and …

A Comparative Study On Nutritional Knowledge And Dietary Behavior Between Korean And Chinese Postpartum Women, Sohyun Kim, Heewon L. Gray, Jia Li, Haeryun Park, Youngmi Lee, Kyunghee Song

Community and Family Health Faculty Publications

Background/Objectives: Proper nutrition intake during pregnancy and lactation is very important to both mothers and babies. Pregnant women should maintain proper nutritional status to restore decreased physical strength due to pregnancy and childbirth and produce breastmilk for the growth and development of the baby. Recently, the number of Chinese people living in Korea has increased as the exchange between Korea and China becomes active. It is important to provide proper nutrition education for pregnant women of both countries considering cultural differences.

Subjects/Methods: The subjects of this study were postpartum women in Gyeonggi, South Korea and Jinhua, China. The subjects were …

Analysis Of Pkc‑Ζ Protein Levels In Normal And Malignant Breast Tissue Subtypes, Tracess Smalley, S. M. Anisul Islam, Christopher Apostolatos, André Apostolatos, Mildred Acevedo-Duncan

Chemistry Faculty Publications

It is estimated that breast cancer will be the second leading cause of cancer‑associated mortality in women in 2018. Previous research has demonstrated that the atypical protein kinase C‑ζ (PKC‑ζ) is a component of numerous dysregulated pathways in breast cancer, including cellular proliferation, survival, and cell cycle upregulation. The present study investigated the PKC‑ζ protein in breast tissue to evaluate its potential as a biomarker for breast cancer invasion, and demonstrated that an overexpression of PKC‑ζ protein can be indicative of carcinogenesis. The present study analyzed the expression of PKC‑ζ in individuals with no tumor complications and malignant female human …

Social Justice, Numeracy, And Teaching Statistics At A Community College, Edward Volchok

Numeracy

The author of this article reflects on the issues of justice, democracy, and numeracy. As one who has taught statistics in a community college for over 12 years, spent 28 years as a Marketing Consultant, and holds a PhD in political science, the author’s thesis is that while an advanced, democratic society can only be just with a numerate citizenry, fostering numeracy is not easy. In this article the author describes the daunting tasks of trying to define what justice is and reviews activities from his statistics class that help students develop their numeracy.

A New 30 Meter Resolution Global Shoreline Vector And Associated Global Islands Database For The Development Of Standardized Ecological Coastal Units, Roger Sayre, Suzanne Noble, Sharon Hamann, Rebecca Smith, Dawn Wright, Sean Breyer, Kevin Butler, Keith Van Usa, Charlie Frye, Deniz Karagulle, Dabney Usahopkins, Drew Stephens, Kevin Kelly, Zeenatul Basher, Devon Burton, Jill Cress, Karina Atkins, D. Paco, Beverly Friesen, Rebecca Allee, Tom Allen, Peter Aniello, Irawan Asaad, Mark John, Kathy Goodin, Peter Harris, Maria Kavanaugh, Helen Lillis, Eleonora Lillis Lillis, Frank Muller-Karger, Bjorn Nyberg, Rost Parsons, Justin Saarinen, Jac Steiner, Adam Reed

Marine Science Faculty Publications

A new 30-m spatial resolution global shoreline vector (GSV) was developed from annual composites of 2014 Landsat satellite imagery. The semi-automated classification of the imagery was accomplished by manual selection of training points representing water and non-water classes along the entire global coastline. Polygon topology was applied to the GSV, resulting in a new characterisation of the number and size of global islands. Three size classes of islands were mapped: continental mainlands (5), islands greater than 1 km2 (21,818), and islands smaller than 1 km2 (318,868). The GSV represents the shore zone land and water interface boundary, and is a …

Challenges For Global Ocean Observation: The Need For Increased Human Capacity, Patricia Miloslavich, Sophie Seeyave, Frank Muller-Karger, Nicholas Bax, Elham Ali, Claudia Delgado, Hayley Evers-King Information, Benjamin Loveday Information, Vivian Lutz Information, Jan Newton Information, Glenn Nolan Information, Ana C. Information, Christine Traeger-Chatterjee Information, Edward Urban Information

Marine Science Faculty Publications

Sustained global ocean observations are needed to recognise, understand, and manage changes in marine biodiversity, resources and habitats, and to implement wise conservation and sustainable development strategies. To meet this need, the Global Ocean Observing System (GOOS), a network of observing systems distributed around the world and coordinated by the Intergovernmental Oceanographic Commission (IOC) has proposed Essential Ocean Variables (EOVs) that are relevant to both the scientific and the broader community, including resource managers. Building a network that is truly global requires expanding participation beyond scientists from well-resourced countries to a far broader representation of the global community. New approaches …

Mental And Physical Health In Prison: How Co-Occurring Conditions Influence Inmate Misconduct, Daniel C. Semenza, Jessica M. Grosholz

Criminology Sarasota Manatee Campus Faculty Publications

Background: Research has shown that inmate misconduct is related to a range of demographic factors and experiences with the criminal justice system. Poor mental and physical health has also been associated with inmate misconduct, although no research has examined the relationship between co-occurring conditions and misconduct in prison populations.

Methods: We rely on data from the 2004 Survey of Inmates in State Correctional Facilities (N = 14,499) and use negative binomial regression models to examine the relationship between types of co-occurring mental and physical conditions and misconduct.

Results: The results demonstrate that people in prison dealing with concurrent mental and …

Traditional Regression Methods Versus The Utility Of Machine Learning Techniques In Forecasting Inmate Misconduct In The United States: An Exploration Of The Prospects Of The Techniques, Fawn T. Ngo, Ramakrishna Govindu, Anurag Agarwal

Criminology Sarasota Manatee Campus Faculty Publications

In the U.S., prison administrators often rely on risk assessment instruments to place and supervise inmates, as well as manage, plan and allocate resources. Hence, any improvement in the accuracy performance of risk assessment instruments is likely to result in significant benefits for offender classification and rehabilitation, management systems, and public safety. To date, researchers have explored the relative predictive performance between regression and non-regression methods and the overall evidence is inconclusive. In this study, we seek to advance the debate regarding the efficacy of traditional regression methods versus the utility of machine learning techniques in forecasting inmate misconduct by …

2019 Accountability Plan St. Petersburg, Usf

USF Accountability Reports

No abstract provided.

2019 Accountability Plan Tampa, Usf

USF Accountability Reports

No abstract provided.

Preoperative Mental Health Scores And Achieving Patient Acceptable Symptom State Are Predictive Of Return To Work After Arthroscopic Rotator Cuff Repair, Anirudh K. Gowd, Gregory L. Cvetanovich, Joseph N. Liu, Benedict U. Nwachukwu, Brandon C. Cabarcas, Brian J. Cole, Brian Forsythe, Anthony A. Romeo, Nikhil N. Verma

Orthopaedics and Sports Medicine Faculty Publications

Background: The incidence of rotator cuff repairs has risen dramatically over the past 10 years, most notably in the working-class population. Return to work (RTW) is a valuable outcome measure to set patient expectations before surgery.

Purpose: To establish the rate of RTW after rotator cuff repair with respect to stratified levels of occupational demand (sedentary, light, moderate, and heavy) and to identify clinical factors significantly associated with postoperative RTW.

Study Design: Cohort study; Level of evidence, 3.

Methods: Patients who received rotator cuff repair between 2014 and 2017 were queried from a prospectively maintained institutional registry. Work status was …

Zika And Flavivirus Shell Disorder: Virulence And Fetal Morbidity, Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Zika virus (ZIKV) was first discovered in 1947 in Africa. Since then, sporadic ZIKV infections of humans have been reported in Africa and Asia. For a long time, this virus was mostly unnoticed due to its mild symptoms and low fatality rates. However, during the 2015–2016 epidemic in Central and South America, when millions of people were infected, it was discovered that ZIKV causes microcephaly in the babies of mothers infected during pregnancy. An examination of the M and C proteins of the ZIKV shell using the disorder predictor PONDR VLXT revealed that the M protein contains relatively high disorder …

Driving Forces Of Liquid–Liquid Phase Separation In Biological Systems, Boris Y. Zaslavsky, Luisa A. Ferreira, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Analysis of liquid–liquid phase separation in biological systems shows that this process is similar to the phase separation observed in aqueous two-phase systems formed by nonionic polymers, proteins, and polysaccharides. The emergence of interfacial tension is a necessary condition of phase separation. The situation in this regard is similar to that of phase separation in mixtures of partially miscible solvents. It is suggested that the evaluation of the effects of biological macromolecules on the solvent properties of aqueous media and the measurement of the interfacial tension as a function of these solvent properties may be more productive for gaining insights …

Structure Determination By Single-Particle Cryo-Electron Microscopy: Only The Sky (And Intrinsic Disorder) Is The Limit, Emeka Nwanochie, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Traditionally, X-ray crystallography and NMR spectroscopy represent major workhorses of structural biologists, with the lion share of protein structures reported in protein data bank (PDB) being generated by these powerful techniques. Despite their wide utilization in protein structure determination, these two techniques have logical limitations, with X-ray crystallography being unsuitable for the analysis of highly dynamic structures and with NMR spectroscopy being restricted to the analysis of relatively small proteins. In recent years, we have witnessed an explosive development of the techniques based on Cryo-electron microscopy (Cryo-EM) for structural characterization of biological molecules. In fact, single-particle Cryo-EM is a special …

Supramolecular Fuzziness Of Intracellular Liquid Droplets: Liquid–Liquid Phase Transitions, Membrane-Less Organelles, And Intrinsic Disorder, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Cells are inhomogeneously crowded, possessing a wide range of intracellular liquid droplets abundantly present in the cytoplasm of eukaryotic and bacterial cells, in the mitochondrial matrix and nucleoplasm of eukaryotes, and in the chloroplast’s stroma of plant cells. These proteinaceous membrane-less organelles (PMLOs) not only represent a natural method of intracellular compartmentalization, which is crucial for successful execution of various biological functions, but also serve as important means for the processing of local information and rapid response to the fluctuations in environmental conditions. Since PMLOs, being complex macromolecular assemblages, possess many characteristic features of liquids, they represent highly dynamic (or …

Development Of A Mel Cell-Derived Allograft Mouse Model For Cancer Research, Min Young Kim, Sungwoo Choi, Seol Eui Lee, Ji Sook Kim, Seung Han Son, Young Soo Lim, Bang-Jin Kim, Buom-Yong Ryu, Vladimir N. Uversky, Young Jin Lee, Chul Geun Kim

Molecular Medicine Faculty Publications

Murine erythroleukemia (MEL) cells are often employed as a model to dissect mechanisms of erythropoiesis and erythroleukemia in vitro. Here, an allograft model using MEL cells resulting in splenomegaly was established to develop a diagnostic model for isolation/quantification of metastatic cells, anti-cancer drug screening, and evaluation of the tumorigenic or metastatic potentials of molecules in vivo. In this animal model, circulating MEL cells from the blood stream were successfully isolated and quantified with an additional in vitro cultivation step. In terms of the molecular-pathological analysis, we were able to successfully evaluate the functional discrimination between methyl-CpG-binding domain 2 (Mbd2) and …

Ifi16, A Nuclear Innate Immune Dna Sensor, Mediates Epigenetic Silencing Of Herpesvirus Genomes By Its Association With H3k9 Methyltransferases Suv39h1 And Glp, Arunava Roy, Anandita Ghosh, Binod Kumar, Bala Chandran

Molecular Medicine Faculty Publications

IFI16, an innate immune DNA sensor, recognizes the nuclear episomal herpes viral genomes and induces the inflammasome and interferon-β responses. IFI16 also regulates cellular transcription and act as a DNA virus restriction factor. IFI16 knockdown disrupted the latency of Kaposi’s sarcoma associated herpesvirus (KSHV) and induced lytic transcripts. However, the mechanism of IFI16’s transcription regulation is unknown. Here, we show that IFI16 is in complex with the H3K9 methyltransferase SUV39H1 and GLP and recruits them to the KSHV genome during de novo infection and latency. The resulting depositions of H3K9me2/me3 serve as a docking site for the heterochromatin-inducing HP1α protein …

Endure, Evolve, Achieve: Stakeholder Perspectives On The Effectiveness Of The Swamp Apes Program In Restoring Biopsychosocial Functioning Of American Veterans, Manisha Joshi, Joshua Zaris Goldman

Social Work Faculty Publications

A growing body of evidence highlights the benefits of recreational outdoor therapy for veterans experiencing posttraumatic stress disorder. We employed the Hawkins Model for “Nature as Strengths-based Recreational Therapy Intervention for Military Members” to assess the Swamp Apes/Volunteer Wilderness Alliance (SA/VWA) in South Florida, which has among its key objectives ridding the Everglades National Park of invasive species (e.g., Burmese python). Focus group and interviews with 10 veterans and seven non-veterans (i.e., family, health providers) were conducted to assess benefits, risks, and potential for developing SA/VWA activities into a formal therapy program for veterans rooted in the American Therapeutic Recreation …