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Remote Language Assessment In School-Age Children With Phelan–Mcdermid Syndrome And Genotype–Phenotype Correlation, Sarah Quadri-Valverde, Jessica Klusek Ph.D., Ccc-Slp, Linda D. Ward, Diana Ivankovic, Nancy Powers, Vijay Shankar, Rachel A. Lyman, Trudy F.C. Mackay, William Bridges, Katy Phelan, Chris Rogers, Luigi Boccuto, Sara M. Sarasua Mar 2026

Remote Language Assessment In School-Age Children With Phelan–Mcdermid Syndrome And Genotype–Phenotype Correlation, Sarah Quadri-Valverde, Jessica Klusek Ph.D., Ccc-Slp, Linda D. Ward, Diana Ivankovic, Nancy Powers, Vijay Shankar, Rachel A. Lyman, Trudy F.C. Mackay, William Bridges, Katy Phelan, Chris Rogers, Luigi Boccuto, Sara M. Sarasua

Faculty Publications

People with Phelan–McDermid syndrome (PMS) have reduced speech and language abilities, yet little research has profiled the communication abilities in this population. The purpose of this study was threefold: identifying the language and communication profiles of school-aged children with PMS, identifying genetic contributions to language and communication abilities, and determining the feasibility of remote data collection for research purposes. A speech language pathologist used standardized assessments and direct evaluations by video conferencing to evaluate language and communication abilities. Sixteen children and adolescents were evaluated: 5 with SHANK3 pathogenic variants, 9 with 22q13 deletions including SHANK3 (PMS-SHANK3 related), and 2 …


Examining The Relationships Between Students’ Achievement Goals And Their Academic Achievement In An Oer-Based Course: A Person-Centered Approach, Hengtao Tang Ph.D., Yan Yang, Yu Bao Mar 2026

Examining The Relationships Between Students’ Achievement Goals And Their Academic Achievement In An Oer-Based Course: A Person-Centered Approach, Hengtao Tang Ph.D., Yan Yang, Yu Bao

Faculty Publications

Open Educational Resources (OER) have emerged as a cost-effective alternative to traditional commercial textbooks in higher education, towards the goal of alleviating college students’ financial burden of educational expenses. However, mixed findings about the influences of the integration of OER on student learning are present. To address the gap, this study investigated whether student motivation in OER served as a latent factor that impacts their academic achievement in online asynchronous courses offered in public universities. Particularly, this study (N = 247) implemented an advanced person-centered approach—stepwise latent class analysis—to profile student achievement goals in an OER-based course and examined their …


The Sortee Guidelines For Data And Code Quality Control In Ecology And Evolutionary Biology, Joel L. Pick, Bethany J. Allen, Benedicte Bachelot, Kevin R. Bairos-Novak, Jack A. Brand, Barbara Class, Tad Dallas, Pietro B. D'Amelio, Erola Fenollosa, Esteban Fernández-Juricic, Dylan G. Gomes, Matthew J. Grainger, Thomas Guillemaud, John Christian, Ruby Krasnow, Malgorzata Lagisz, Sebastian Lequime, Daniel S. Maynard, Shinichi Nakagawa, Rose E. O'Dea, Et. Al. Mar 2026

The Sortee Guidelines For Data And Code Quality Control In Ecology And Evolutionary Biology, Joel L. Pick, Bethany J. Allen, Benedicte Bachelot, Kevin R. Bairos-Novak, Jack A. Brand, Barbara Class, Tad Dallas, Pietro B. D'Amelio, Erola Fenollosa, Esteban Fernández-Juricic, Dylan G. Gomes, Matthew J. Grainger, Thomas Guillemaud, John Christian, Ruby Krasnow, Malgorzata Lagisz, Sebastian Lequime, Daniel S. Maynard, Shinichi Nakagawa, Rose E. O'Dea, Et. Al.

Faculty Publications

Open data and code are crucial to increasing transparency and reproducibility, and in building trust in scientific research. However, despite an increasing number of journals in ecology and evolutionary biology mandating for data and code to be archived alongside published articles, the amount and quality of archived data and code, and subsequent reproducibility of results, has remained worryingly low. As a result, a handful of journals have recruited dedicated data editors, whose role is to help authors increase the overall quality of archived data and code. There is, however, a general lack of consensus around what a data editor should …


Social Network Determinants Of Cigarette Forgoing And Quit-Related Conversations In A 15-Day Ecological Momentary Assessment Study In Mexico And The Us, Lizeth Cruz-Jiménez, Kevin A. Carson, Jim Thrasher Ph.D., Ma, Ms, Katia Gallegos-Carrillo, Dèsirée Vidaña-Pérez, Diego F. Leal Mar 2026

Social Network Determinants Of Cigarette Forgoing And Quit-Related Conversations In A 15-Day Ecological Momentary Assessment Study In Mexico And The Us, Lizeth Cruz-Jiménez, Kevin A. Carson, Jim Thrasher Ph.D., Ma, Ms, Katia Gallegos-Carrillo, Dèsirée Vidaña-Pérez, Diego F. Leal

Faculty Publications

Introduction

It is unclear why people of Mexican ancestry who smoke report relatively high rates of discussing quitting-related topics, which predicts cessation attempts.

Methods

Using Ecological Momentary Assessment (EMA), adults from Mexico (n=40) and with Mexican heritage living in the US (n=52) who smoked daily were sent texts/emails each morning with cessation tips and cessation benefits over 15 days. At baseline, participants reported their personal network characteristics across up to eight different alters. Each evening of the 15 days, participants reported forgoing any cigarettes they normally would smoke (yes/no) and having had any quitting-related conversations (yes/no). Multilevel logistic models were …


Rewriting The Rules: Game-Based Learning For Affective And Cognitive Student Engagement In An Undergraduate History Course, Rachel Hoke, James Risk Mar 2026

Rewriting The Rules: Game-Based Learning For Affective And Cognitive Student Engagement In An Undergraduate History Course, Rachel Hoke, James Risk

Faculty Publications

Constructivist psychology has long demonstrated the potential for play to offer various benefits to learning. This study introduced active game-based learning experiences, in the form of role-playing games, into an undergraduate history course that also included passive lecture and discussion elements. Mixed methods student feedback surveys were used to examine the impacts of game-based learning on students’ affective and cognitive engagement in the course and offer a comparison between the lecture and game-based learning experiences. Qualitative data were analyzed through the paradigm of Mohsen, Abdollahi, and Omar’s (2019, 518-520) framework for educational value, including affective evaluation, conceptual understanding, skill development, …


Hyoid Bone Fracture In A Division 1 Football Player: A Conservative Management Case Study, Kynnedy Louis, Andrew Crane, Mark Knoblauch, Layci Harrison Mar 2026

Hyoid Bone Fracture In A Division 1 Football Player: A Conservative Management Case Study, Kynnedy Louis, Andrew Crane, Mark Knoblauch, Layci Harrison

Clinical Practice in Athletic Training

Introduction: The hyoid bone plays an important role in speaking, swallowing, and supporting the tongue. Hyoid bone fractures account for 0.002% of all fractures and are typically seen in cases dealing with strangulations or a blunt force trauma such as occurs from vehicle accidents or martial arts injuries. Signs and symptoms of hyoid fractures can include dyspnea, pharyngeal tear, or subcutaneous emphysema, and if not recognized early can significantly damage the airway. Patient Information: A 23-year-old male collegiate football player sustained blunt trauma to the anterior part of his neck due to a tackle forcing the helmet chin strap against …


Trust, Culture, And Conversation: How Athletic Training Leaders Navigate High-Stakes Interactions, Nicole A. Wilkins, Ashley B. Thrasher, Ericka P. Zimmerman Mar 2026

Trust, Culture, And Conversation: How Athletic Training Leaders Navigate High-Stakes Interactions, Nicole A. Wilkins, Ashley B. Thrasher, Ericka P. Zimmerman

Clinical Practice in Athletic Training

Introduction: Engaging in difficult conversations is central to leadership growth and requires sustained effort to refine and strengthen these skills. Leaders not only need to navigate the complexities of their role within an organization, but also the intersectionality of interpersonal dynamics, emotional intelligence, structural hierarchies, and the nuanced environments that influence how communication occurs. Furthermore, leaders must adapt to role expectations that shift across clinical, academic, and administrative contexts, adjusting their approach to engaging in conversations based on these complexities. As part of a larger research project examining difficult conversations, this portion of the study explored how leaders in athletic …


March 4, 2026 Faculty Senate Minutes, University Of South Carolina Mar 2026

March 4, 2026 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.


Cognitive And Emotional Conflict Control Among Children Affected By Parental Hiv/Aids In China, Huihui Wang, Juan Liu, Danfeng Wen, Wan Zhao, Xiaoming Li Ph.D., Junfeng Zhao Mar 2026

Cognitive And Emotional Conflict Control Among Children Affected By Parental Hiv/Aids In China, Huihui Wang, Juan Liu, Danfeng Wen, Wan Zhao, Xiaoming Li Ph.D., Junfeng Zhao

Faculty Publications

Background: Children affected by parental HIV/AIDS constitute a particularly vulnerable population, often facing heightened risks in psychosocial adaptation due to family disruption, social stigma, and resource deprivation. However, the characteristics of their executive functions, particularly the core component of conflict monitoring, remain unclear.

Methods: The present study compared the performance of children affected by parental HIV/AIDS (n=32) to a control group (n=32) on a cognitive conflict and emotional conflict face-word Stroop task.

Results: The results of the cognitive Stroop task demonstrated that both groups showed better performance in congruent stimuli compared to incongruent stimuli (86.20% vs.67.30%; 568.43ms vs.586.04ms). In the …


Impediments To Transforming The Healthcare Delivery System: Shifting The Paradigm From Provider Centric To Patient Centric, Elizabeth A. Regan, Manasa Devi Chinta Mar 2026

Impediments To Transforming The Healthcare Delivery System: Shifting The Paradigm From Provider Centric To Patient Centric, Elizabeth A. Regan, Manasa Devi Chinta

Faculty Publications

Introduction: 

Stated aims for digital healthcare transformation frequently cite goals for better coordinated patient-centric systems. However, despite advances in medical science, digital technologies, health policies, and billions of dollars invested over the past 25 years, most healthcare providers are far from fully realizing the demonstrated benefits of today's digital technologies for improving patient care. Sharing information across healthcare systems remains challenging. Problems with fragmentation, quality, inequities, and rising costs of care delivery persist. A recent study of 1,026 U.S. hospital systems found that only 15.8 percent achieved a digital maturity level needed to provide digitally enabled healthcare services to better …


Handling Item-Level Missing Data In Linear Regression: A Tutorial, Guyin Zhang, Lihan Chen, Dexin Shen Mar 2026

Handling Item-Level Missing Data In Linear Regression: A Tutorial, Guyin Zhang, Lihan Chen, Dexin Shen

Faculty Publications

With advances in methodology and statistical software, modern methods for handling missing data have become more accessible and straightforward to apply. In psychological studies, researchers often use questionnaires or scales composed of multiple items to measure constructs of interest. As a result, missing values frequently occur at the item level, whereas data analyses are typically conducted at the scale (composite) level. However, properly addressing item-level missing data remains a common challenge for many applied psychologists, including researchers who are otherwise well experienced in handling missing data at the scale level. In this tutorial, we introduce six approaches for handling item-level …


Building Buy-In For Student Support Teams: Lessons From Givhans To Carolina Springs, Patrice Green Mar 2026

Building Buy-In For Student Support Teams: Lessons From Givhans To Carolina Springs, Patrice Green

South Carolina Association for Middle Level Education Journal

This article examines strategies for cultivating staff buy-in and sustaining effective Student Support Teams (SSTs) within a Multi-Tiered System of Supports (MTSS) framework at the middle school level. Drawing from the author’s personal experiences of overcoming adversity and his leadership journey from rural Givhans, South Carolina, to serving as principal of Carolina Springs Middle School, the narrative highlights the critical role of intentional, data- driven interventions in promoting equitable student outcomes. The discussion emphasizes the necessity of proactive identification, individualized support, and collaborative problem-solving among educators. Common implementation challenges—such as staff resistance, initiative fatigue, and inconsistent follow-through—are addressed through actionable …


South Carolina Middle School Student Performance In Ela And Mathematics: The Imperative Of Assessment For Learning, Olivia S. Ochoo Mar 2026

South Carolina Middle School Student Performance In Ela And Mathematics: The Imperative Of Assessment For Learning, Olivia S. Ochoo

South Carolina Association for Middle Level Education Journal

Despite broad access to middle school in South Carolina, recent SCReady assessment data indicate persistent literacy and numeracy achievement gaps, with so many students performing below grade level in English Language Arts (ELA) and mathematics. This article evaluated five years of state- and district-level data, highlighting steady but small gains, and explored how current assessment practices failed to fully inform instruction to accelerate learning. This paper used a mixed-methods research design, particularly a convergent parallel mixed-methods design, in which both qualitative and quantitative approaches were used to collect and analyze data. To be specific, document analysis and both open- and …


Middle School Magic: Building Belonging And Brain-Aligned Classrooms, Christopher S. Culver, Katie Kinder Mar 2026

Middle School Magic: Building Belonging And Brain-Aligned Classrooms, Christopher S. Culver, Katie Kinder

South Carolina Association for Middle Level Education Journal

Middle school represents a critical developmental period when belonging, identity, and emotional regulation converge to shape academic and social outcomes. This article explores how belonging and brain-aligned kindness transform classroom culture through connection, collaboration, compassion, and the Science of Kindness. Drawing from recent neuroscience, educational psychology, and classroom practice, the authors demonstrate how these principles activate neural pathways of safety, motivation, and empathy that enhance learning and well- being. Integrating research with actionable classroom strategies, this article illustrates how small, consistent acts of care, such as greeting students by name, fostering collaborative learning, building relationships in trust, and practicing restorative …


Mental Health And Neurodiversity In Middle Grades Literature: Sharing Stories Of Anxiety, Identity, And Resilience For Today’S Adolescents, Brooke B. Eisenbach Mar 2026

Mental Health And Neurodiversity In Middle Grades Literature: Sharing Stories Of Anxiety, Identity, And Resilience For Today’S Adolescents, Brooke B. Eisenbach

South Carolina Association for Middle Level Education Journal

Literature offers a powerful entry point for classroom conversation and engagement around mental health and neurodiversity. Stories invite students to challenge stereotypes and deepen their understanding through exploration of character, conflict, and voice, rather than through lecture or the expectation of personal self-disclosure. This article examines five contemporary novels exploring topics of mental health and neurological diversity that teachers can utilize to integrate mental health and social-emotional learning in the classroom. Through authentic voices and relatable narratives, these stories provide educators, parents, and teens with meaningful insights into the realities of navigating challenges while emphasizing resilience, self-worth, and the power …


Understanding Distracted Minds: A Review Of Stolen Focus, Tammy J. Burnham Dr. Mar 2026

Understanding Distracted Minds: A Review Of Stolen Focus, Tammy J. Burnham Dr.

South Carolina Association for Middle Level Education Journal

This review examines Hari's Stolen Focus: Why You Can't Pay Attention—and How to Think Deeply Again, an exploration of society's lack of sustained attention in an increasingly digital world. Hari's investigation of technology's impact on cognitive abilities provides meaningful insights for those in the educational field, where educators must guide young people through social media environments. Hari argues that systemic forces are disabling attention spans, and he evaluates practical solutions for educators and parents. Stolen Focus is an important resource for educators committed to supporting students' cognitive development and mental well-being.


Front Matter Mar 2026

Front Matter

South Carolina Association for Middle Level Education Journal

No abstract provided.


Scamle Journal 2026 Full Volume Mar 2026

Scamle Journal 2026 Full Volume

South Carolina Association for Middle Level Education Journal

No abstract provided.


Fuck: Public Opinion, Ian T. Adams, Marc Olson, Lois James, Brandon Tregle, Hunter M. Boehme Mar 2026

Fuck: Public Opinion, Ian T. Adams, Marc Olson, Lois James, Brandon Tregle, Hunter M. Boehme

Faculty Publications

Profanity is common in everyday life, yet law enforcement often treats all swear words alike. Building on Adams (2024), we surveyed a large public sample (n = 2412) who evaluated profanity’s appropriateness, professionalism, impact on trust, and disciplinary deservedness across nine scenarios (n = 9874) varying in intent (positive, neutral, derogatory) and target (self/situation, colleague, public). Results aligned with prior research: any profanity aimed at the public, especially in a derogatory way, drew the strongest condemnation. Meanwhile, positive or neutral profanity toward oneself or colleagues was generally acceptable, though derogatory profanity at colleagues elicited moderate concern. Across the …


Does Genetic Testing Influence Outcomes: Early Experience In Melanoma Case Series, Ryan Reyes, George Skenteris, Stella Coker Watson Self Ph.D., Ms, Christine Marie-Gilligan Schammel, Steven D. Trocha Mar 2026

Does Genetic Testing Influence Outcomes: Early Experience In Melanoma Case Series, Ryan Reyes, George Skenteris, Stella Coker Watson Self Ph.D., Ms, Christine Marie-Gilligan Schammel, Steven D. Trocha

Faculty Publications

Background:

The treatment and prognosis of melanoma have historically been based on histologic stage and Breslow depth; however, due to the increase in surveillance, melanomas are being identified at an earlier stage and lower Breslow depth. Advances in genetic testing, such as Decision Dx®, mean that melanoma diagnostic decisions and prognosis can now be directed by genetics. The purpose of this project was to assess the influence of a Decision Dx® high-grade (Class 2A/B) classification on the treatment of melanoma patients at a regional medical center, particularly those not deemed high risk by conventional classification methods, including Breslow depth and …


Using The Misinformation Exposure-Trust Framework For Audience Segmentation: Predicting Covid-19 Vaccine Hesitancy Among U.S., Jing Zeng, Jinxu Li, Nan Yu, Xi Cui, Anli Xiao Ph.D. Feb 2026

Using The Misinformation Exposure-Trust Framework For Audience Segmentation: Predicting Covid-19 Vaccine Hesitancy Among U.S., Jing Zeng, Jinxu Li, Nan Yu, Xi Cui, Anli Xiao Ph.D.

Faculty Publications

This study examines whether individuals’ exposure to and trust in COVID-19 vaccine misinformation can be used to segment audiences and explain variations in vaccine hesitancy and health beliefs. Using k-means clustering, a survey of 819 U.S. college students (March–May 2021) identifies four subgroups based on combinations of high or low misinformation exposure and trust: misinformation-shielded (low exposure, low trust), misinformation-vulnerable (low exposure, high trust), misinformation-resistant (high exposure, low trust), and misinformation-accepting (high exposure, high trust). These subgroups differ significantly in political ideology, vaccine hesitancy, and health beliefs. The misinformation-shielded subgroup reports more liberal views, lower hesitancy, and higher perceived efficacy, …


The Effect Of St. John’S Wort Solution On Climbing Activity Reflecting Depressive-Like Behavior In Drosophila Melanogaster To Model Seasonal Depression In Low Sunlight Exposure, Madison Simon Feb 2026

The Effect Of St. John’S Wort Solution On Climbing Activity Reflecting Depressive-Like Behavior In Drosophila Melanogaster To Model Seasonal Depression In Low Sunlight Exposure, Madison Simon

Journal of the South Carolina Academy of Science

Although depression is a known substantial threat to public health, seasonal affective disorder (SAD) is under-researched. SAD refers to recurrent seasonal patterns of depression. This depressive disorder has few accepted treatments. The purpose of this study was to test whether St. John’s Wort (SJW), a natural supplement with researched antidepressant properties, could be a cheaper alternative with fewer limitations for treating SAD. SJW’s efficacy as a seasonal depression inhibitor was tested through a Drosophila depression-like model using climbing activity to reflect depressive behavior. It was hypothesized that as the concentration of SJW solution increases, the climbing activity of stressed Drosophila …


Assessing Working Musicians’ Perspectives Of Need And Barriers Regarding Lay Harm Reduction Efforts For Substance-Related Harm In South Carolina, Sarah Grace Frary Feb 2026

Assessing Working Musicians’ Perspectives Of Need And Barriers Regarding Lay Harm Reduction Efforts For Substance-Related Harm In South Carolina, Sarah Grace Frary

Faculty Publications

Background

Harm Reduction (HR) approaches applied to substance use aim to decrease the toxic consequences of overdose. The addition of xylazine and benzodiazepines to fentanyl, the primary opioid in the US drug supply, increases the likelihood of overdose. Likewise, adding fentanyl to other popular substances, such as cocaine and methamphetamine, has further driven the exponential increase in opioid and stimulant overdoses. Engaging lay community members in HR efforts may help to combat the overdose crisis. Substance use is common in live music settings, and working musicians may be uniquely positioned within “the scene” – individuals who populate specific cultural niches …


The Daily Gamecock: February 2026, University Of South Carolina, Office Of Student Media Feb 2026

The Daily Gamecock: February 2026, University Of South Carolina, Office Of Student Media

2026

No abstract provided.


Physical And Behavioral Health Diagnoses And Comorbidities Associated With Transition From Military Health System To Veterans Health Care Among Post-9/11 Veterans, Niki Wooten Phd, Lisw-Cp, Megan E. Amaun, Madeleine Myers, Prince N.O. Addo, Jeffrey Bowers, Felicia R. Carey, Rudolph P. Rull, Edward J. Boyko, Nathaniel Bell Ph.D., Ana Lopéz-De Fede, Mary Jo V. Pugh Feb 2026

Physical And Behavioral Health Diagnoses And Comorbidities Associated With Transition From Military Health System To Veterans Health Care Among Post-9/11 Veterans, Niki Wooten Phd, Lisw-Cp, Megan E. Amaun, Madeleine Myers, Prince N.O. Addo, Jeffrey Bowers, Felicia R. Carey, Rudolph P. Rull, Edward J. Boyko, Nathaniel Bell Ph.D., Ana Lopéz-De Fede, Mary Jo V. Pugh

Publications

Objective

To identify factors associated with transitioning from Military Health System (MHS) to Veterans Health Administration (VHA) care in post-9/11 veterans.

Study Setting and Design

Retrospective cohort study from the Long-Term Impact of Military-Relevant Brain Injury Consortium Phenotype Study.

Data Sources and Analytic Sample

Population-level data were analyzed from MHS and VHA electronic health data (FY2000-2020). Participants received ≥ 3 years of MHS care and separated from the military before October 1, 2016. The primary outcome was transition from MHS to VHA care after military separation. Covariates included demographic, military, and deployment characteristics at military separation; physical, mental, and substance …


Ichps Special Issue Introduction, Donna Coffman, Recai M. Yucel Feb 2026

Ichps Special Issue Introduction, Donna Coffman, Recai M. Yucel

Faculty Publications

No abstract provided.


Us Federal Budgets And Federal Employee Job Satisfaction, Nathan Favero, Carla Flink, Tingli Qu Feb 2026

Us Federal Budgets And Federal Employee Job Satisfaction, Nathan Favero, Carla Flink, Tingli Qu

Faculty Publications

Researchers have long studied how organizational budgets relate to performance, but how do employees themselves experience the effects of budgetary decisions? Given widespread attention to political dysfunction in US federal budgeting, conventional wisdom holds that employees are negatively affected by budgetary uncertainty (volatility, delays, and stop-gap measures). We test how budget size and uncertainty are associated with US federal employee attitudes using survey and archival data from 2005 to 2020. Results provide some evidence that employee job satisfaction improves with enhanced funds, but there is little to no support for the notion that budgetary uncertainty influences federal employees' job satisfaction.


Equal Chances Or Fewer Victims? Moral Judgments In Autonomous Vehicle Dilemmas, Alexander Matros, Eren Bilen, Leonid Matros Feb 2026

Equal Chances Or Fewer Victims? Moral Judgments In Autonomous Vehicle Dilemmas, Alexander Matros, Eren Bilen, Leonid Matros

Faculty Publications

We examine the moral dilemma of how autonomous vehicles (AVs) should be programmed to act in unavoidable crash scenarios involving trade-offs between saving one life and saving many. We report results from three experimental studies that investigate individuals’ preferences over alternative AV decision rules in stylized crash scenarios. Across designs, we find robust support for a probabilistic decision rule that assigns passengers and pedestrians equal ex ante chances of survival (a 50:50 rule). This preference persists across different framings and remains salient even when additional probabilistic options are introduced.


February 4, 2026 Faculty Senate Minutes, University Of South Carolina Feb 2026

February 4, 2026 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.


Cost-Effectiveness Of Pregabalin, Duloxetine, And Milnacipran Vs Amitriptyline For Moderate To Severe Fibromyalgia, Sarah S. Downen, Hussein M. Farag, Abby Davis, Chijioke M. Okeke, Kenechukwu C. Ben-Umeh, Ismaeel Yunusa Ph.D., Tewodros Eguale Feb 2026

Cost-Effectiveness Of Pregabalin, Duloxetine, And Milnacipran Vs Amitriptyline For Moderate To Severe Fibromyalgia, Sarah S. Downen, Hussein M. Farag, Abby Davis, Chijioke M. Okeke, Kenechukwu C. Ben-Umeh, Ismaeel Yunusa Ph.D., Tewodros Eguale

Faculty Publications

Importance

Fibromyalgia (FM) is a chronic pain condition associated with substantial quality-of-life impairments and economic burden. Although multiple pharmacologic options are recommended in clinical guidelines, the relative cost-effectiveness of off-label amitriptyline compared with FDA-approved treatments remains poorly defined due to a scarcity of direct economic comparisons and the use of heterogenous outcome measures in the extant literature.

Objective

To evaluate the cost-effectiveness of pregabalin, duloxetine, and milnacipran compared with amitriptyline in adults with moderate to severe FM.

Design, Setting, and Participants

Decision analytical model using a Markov cohort state transition model to estimate lifetime costs and quality-adjusted life-years (QALYs) for …