Digital Commons Network^™

Cost-Effectiveness Analysis Of Aducanumab Versus Placebo For Patients With Mild Cognitive Impairment And Mild Alzheimer’S Disease, Xiaomo Xiong, Gang Lv, Jacob Jordan King, Minghui Li, Jing Yuan, Z Kevin Lu

Faculty Publications

Objectives To assess the cost-effectiveness of aducanumab at its updated price for treating patients with mild cognitive impairment (MCI) and mild Alzheimer’s disease (AD).

Design Cost-effectiveness analysis.

Settings A five-state Markov model was constructed using 10 000 virtual patients to assess the cost-effectiveness of aducanumab from the perspective of the US healthcare system. The model employed a one-year cycle time and a lifetime time horizon. Transition probabilities and mortality rates were derived from a literature review. To address uncertainty and generalise the base case results, both one-way and probabilistic sensitivity analyses were conducted.

Participants 10 000 virtual patients with MCI …

The Daily Gamecock: April 2025, University Of South Carolina, Office Of Student Media

2025

No abstract provided.

Displaced Decarbonization: Climate Necropolitics And The Contested Spatialities Of Green Hydrogen In Namibia, Meredith J. Deboom

Faculty Publications

Green hydrogen is often presented as a transformative solution to the dual challenges of decarbonization and economic development. This article applies the framework of climate necropolitics to interrogate the contested spatialities underlying such “win-win” narratives. It does so through an extended case study of Hyphen Hydrogen Energy, a $10 billion green hydrogen project planned for Lüderitz, Namibia. A remote town of 20,000 in a country with a $12 billion annual GDP, Lüderitz initially appears to be an unlikely host site for the “industrial fuel of the future.” To explain this outcome, I first illustrate how discordant socio-spatial projects—including European energy …

Two-Layer Formulation For Long-Runout Turbidity Currents: Theory And Bypass Flow Case, Hongbo Ma, Gary Parker, Matthieu Cartigny, Enrica Viparelli, S. Balachandar, Xudong Fu, Rossella Luchi

Faculty Publications

Turbidity currents, which are stratified, sediment-laden bottom flows in the ocean or lakes, can run out for hundreds or thousands of kilometres in submarine channels without losing their stratified structure. Here, we derive a layer-averaged, two-layer model for turbidity currents, specifically designed to capture long-runout. A number of previous models have captured runout of only tens of kilometres, beyond which thickening of the flows becomes excessive, and the models without a lateral overspill mechanism fail. In our framework, a lower layer containing nearly all the sediment is a faster, gravity-driven flow that propels an upper layer, where sediment concentration is …

A Brave New World Of Human Resources Research: Navigating Perils And Identifying Grand Challenges Of The Genai Revolution, Anthony Nyberg, Deidra J. Schleicher, Bradford S. Bell, Corine Boon, Peter Cappelli, David G. Collings, Joseph E. Dalle Molle, Stefan Feuerriegel, Berry Gerhart, Yoojin Jeong, M. Audrey Korsgaard, Dana Minbaeva, Robert E. Ployhart, Prasanna Tambe, Ingo Weller, Patrick M. Wright, Valery Yakubovich

Faculty Publications

This paper reviews the transformative role of Generative Artificial Intelligence (GenAI) in Human Resource (HR) management, from a practice perspective, highlighting both opportunities and challenges and laying out a use-inspired future research agenda. This scoping review is grounded in insights from a unique Summit held in Spring 2024, which brought together HR academic scholars with dozens of Fortune 500 Chief Human Resource Officers (CHROs) and their top technical leaders to discuss the workforce implications of GenAI. The paper identifies six key themes from the Summit practitioners: GenAI as disruptive and transformative, data as competitive advantage, adoption challenges, potential ethical abuses, …

A Reliable And Efficient Detection Pipeline For Rodent Ultrasonic Vocalizations, Sabah Shahnoor Anis, Devin Mark Kellis, Kris Ford Kaigler, Marlene A. Wilson, Christian O'Reilly

Faculty Publications

Analyzing ultrasonic vocalizations (USVs) is crucial for understanding rodents' affective states and social behaviors, but the manual analysis is time-consuming and prone to errors. Automated USV detection systems have been developed to address these challenges. Yet, these systems often rely on machine learning and fail to generalize effectively to new datasets. To tackle these shortcomings, we introduce ContourUSV, an efficient automated system for detecting USVs from audio recordings. Our pipeline includes spectrogram generation, cleaning, pre-processing, contour detection, post-processing, and evaluation against manual annotations. To ensure robustness and reliability, we compared ContourUSV with three state-of-the-art systems using an existing open-access USV …

Deep Jansen-Rit Parameter Inference For Model-Driven Analysis Of Brain Activity, Deepa Tilwani, Christian O'Reilly

Faculty Publications

Accurately modeling effective connectivity (EC) is critical for understanding how the brain processes and integrates sensory information. Yet, it remains a formidable challenge due to complex neural dynamics and noisy measurements such as those obtained from the electroencephalogram (EEG). Model-driven EC infers local (within a brain region) and global (between brain regions) EC parameters by fitting a generative model of neural activity onto experimental data. This approach offers a promising route for various applications, including investigating neurodevel- opmental disorders. However, current approaches fail to scale to whole-brain analyses and are highly noise-sensitive. In this work, we employ three deep-learning architectures—a …

Examining Physiological Responses To Misophonic Triggers, Christian O'Reilly, Xuan Yang, Sewon Oh, Doug Wedell, Svetlana Shinkareva

Faculty Publications

We collected and analyzed an array of biosignals (face electromyogram, skin electrodermal activity, peripheral temperature, and electrocardiogram) in 60 participants with and without misophonia, a condition characterized by decreased tolerance to innocuous sounds. Our goal was to objectively characterize the physiological response to misophonia triggering sounds. We found that misophonic responses can be objectively identified in some cases through atypical physiological reactions to triggering stimuli, though not all participants exhibited this response. Our analyses suggest a large interindividual variability in response to misophonic triggers and highlights the need for methodological adjustments in future experiments to increase the detectability of misophonic …

“They Are Fat And Want Special Treatment For Being Fat”: Backlash To And Lay Theories Of Fat Activism, Flora Blanchette-Oswald, Minh Duc Pham, R. J. Harr, Alexandra Garr-Schultz, Kimberly E. Chaney

Faculty Publications

Fat activism is a movement that seeks to acknowledge and eliminate the oppression of fat people. The movement and those who participate face significant backlash, yet fat activism is understudied. We sought to understand lay theories about fat activism; that is, how everyday people think about the goals and motivations of fat activism, and people who engage in fat activism, to understand how these perceptions shape support for and backlash toward fat activism. In Study 1 (N = 294), we qualitatively elucidated lay theories of fat activism in a US nationally representative sample. We identified lay theories that both …

Focal Adhesion Genes And Proteins Are Differentially Expressed Across Cell Types In Down Syndrome, Brian Yoon

Senior Theses

Down syndrome (DS), caused by an extra copy of chromosome 21, leads to widespread gene expression changes through mechanisms such as transcriptional dysregulation and altered protein interactions. These disruptions contribute to a range of clinical features, including impaired wound healing, immune dysfunction, and neurodevelopmental abnormalities. This study focused on how DS affects fibroblast morphology and motility—processes critical for tissue repair and brain development. Using quantitative immunocytochemistry and image analysis, we found that DS fibroblasts displayed a broader, less polarized shape, with increased cell perimeter and reduced aspect ratio. However, levels of key adhesion proteins like vinculin, FAK, and β-actin were …

Achieving Total Health Using Food To Heal: A Podcast On A Holistic Approach To Nutrition, Taylor Sharer

Senior Theses

Nutrition is the key to a healthy and happy life. In a world where chronic, avoidable diseases are the leading cause of death, it is necessary to educate the public on how they can improve their overall health and wellbeing using food. Every aspect of health is interconnected, and what we eat can create massive changes in our health. My project focuses on holistic nutrition, providing an easily accessible, science-based and informative discourse about how to reach health and wellness goals through a podcast. Using personalized experience combined with current research, I discuss topics such as whole foods, individualized nutrition, …

Repositioning The Game: Traditional Positions Vs Tracking-Based Archetypes In Nba Performance Models, Jacob Floyd

Senior Theses

Driven by the rise of advanced analytics and player tracking technologies, the NBA has transitioned away from traditional positional roles and toward more fluid player archetypes. This investigation uses principal component analysis and k-means clustering to group players based on season-long tracking data, creating new pseudo-positions that more accurately reflect modern playing styles. Predictive models were then built using both the classic position system and the newly generated clusters to forecast player scoring performance. Across every model comparison, both in terms of fit and predictive accuracy, the cluster-based system significantly outperformed the traditional position-based model. These results reinforce the idea …

Articulation As A Predictor Of Cognitive Decline, Sarah G. Hammons

Senior Theses

Background: Speech production is facilitated by motor neural networks that are proximal to neural substrates of general cognitive functions in the frontal lobe. However, the precise relationship between these brain networks supporting articulatory control and more general cognitive functioning has not been determined. A relation may be expected due to the anatomical proximity of specific networks, or due to more global aspects of brain health in individuals, affecting cognitive and motor functions across the board. Lower motor function is expected to affect the stability of speech production, but the extent to which this is also associated with lower cognitive functioning …

Are The Kids Alright? An Analysis Of Sex Education, The Sexual Behaviors Of Minors And Age Of Consent Laws In The United States, Monica L. Johnston

Senior Theses

This paper explores the sexual development of children, the sexual education they receive, as well as the history of sex laws in the United States, to determine whether the laws regarding education and age of consent adequately protect children. A qualitative survey is also conducted with undergraduate students at the University of South Carolina to determine what topics were discussed in their sexual education curriculum, as well as their sexual behaviors as a minor. While the push for comprehensive sexual education models has been growing, millions of dollars are still being allocated to promote Abstinence Only Until Marriage programs, which …

Delta-8 Tetrahydrocannabinol Policy And Related Health Impact Among College-Aged Individuals In South Carolina: A Scoping Review, Emily K. Luoma

Senior Theses

After the 2018 Farm Bill passed, loopholes were quickly found that led to the popularization of delta-8 THC, a derivative of delta-9 THC, more commonly known as marijuana. Use of this substance became particularly high in states that criminalized marijuana, such as South Carolina. This scoping review aimed to assess South Carolina’s current delta-8 policies in the context of health-related impacts among college-aged students. Comprehensively analyzing the results of relevant studies, it was determined that there are three commonly observed threats to public health that are direct outcomes of existing policies: 1) a lack of quality control standards; 2) misleading …

Ocd Online: Strategies To Build Engagement For Mental Health Content On Social Media, Casey Matthews

Senior Theses

Social media is a tool with the potential to shape health communication. This study seeks to apply models of social media engagement from brand communication studies to explore how social media practitioners can effectively build engagement for mental health messaging. The study takes root in the concepts of social media engagement behavior (SMEB) and active vs. passive engagement outlined in the work of Dolan et al. (2019) and Shahbaznezhad et al. (2022). The application of these concepts to health communication provides new insight into the effectiveness of various messaging strategies—with a focus on OCD, a disorder that faces high levels …

The Stigma Surrounding Sex And Sexuality In American Culture, Sophia L. Pollock

Senior Theses

An important question to examine is the origin and implications of the taboo against sex and sexuality. The stigma against these topics encourages negative public health implications like poor sex education, high rates of sexually transmitted infections, and teen pregnancy. History of sexual stigma was examined through physical media and digital articles from the Thomas Cooper Library databases. The background and global perspective of these stigmas are covered, examining how past and distant cultures deal with sex. How sex is portrayed in the media, why a healthy sex life is important, and the subject of sex education are also addressed. …

How Do Children Learn How To Learn? Promoting Early Development At Home Through Play: A Scoping Review, Annika J. Larson

Senior Theses

Early childhood is a critical time in human development, during which children are discovering and practicing countless skills, from basic motor and language skills to problem-solving, self-regulation, memory, and other foundational abilities like literacy and math skills. From infancy through childhood, play is thought to be the primary condition under which most early skills are developed and perfected. During this time, young children are especially vulnerable to adversity and negative environmental influences due to their brains’ high plasticity; adverse childhood experiences (ACEs) impact an individual well beyond early childhood, specifically in early skills deficits. Play is known to be a …

Physiological Indicators Of Social Anxiety In Preschoolers With The Fragile X Premutation, Olivia Cyburt

Senior Theses

The Fragile X premutation (FXpm) is a common genetic disorder often characterized by psychiatric impairments, including anxiety. It results from a trinucleotide repeat expansion (CGG) of 55-200 repeats on the FMR1 gene. Despite its association with psychiatric symptoms, there is limited research regarding the relationship between FXpm and anxiety, particularly social anxiety. Early detection of social anxiety is essential for timely intervention, yet it remains challenging to identify in young individuals with FXpm due to limited research. The present study aimed to bridge this gap by examining social anxiety in preschoolers with the FXpm, utilizing both a physiological and behavioral …

Table Of Contents

The Journal of Law and Education

No abstract provided.

Act 388: An Examination Of How An Obscure Property Tax Law Revolutionized Property Tax Funding In South Carolina, Katie Boyette

The Journal of Law and Education

No abstract provided.

The Art Of Advocacy Revealed Through Law School Curriculum, Ashley Jones Hall

The Journal of Law and Education

No abstract provided.

No Child Left Behind Bars: The Educational Attainment Of Children With Incarcerated Parents, Nate Tackett

The Journal of Law and Education

No abstract provided.

Increasing Diversity In The Genetic Counseling Profession: Determining Effective Career Education Strategies For Underrepresented Youth, Bryel Marie Frasch

Theses and Dissertations

Genetic counseling is a professional career path that is lacking in diversity, and diversity in healthcare has been shown to improve health outcomes. Studies suggest student engagement as a way to increase diversity, as early knowledge of genetic counseling increases the likelihood of considering it as a career and is especially true for racial or ethnic minoritized students. This study focused on educating high school students underrepresented in genetic counseling about the career and exploring the effectiveness of two different types of education methods (video vs in-person) to give valuable information for future outreach efforts. Upward Bound and Federal TRIO …

Brain Specific Elevations Of Kynurenic Acid, Charles A. Grant

Senior Theses

Individuals who suffer from neurocognitive disorders often suffer from sleep disturbances. Kynurenic acid (KYNA) is a tryptophan metabolite implicated in the pathophysiology of these disorders. Modest increases in KYNA, which acts as an antagonist at N-methyl-D-aspartate (NMDA) and α7 nicotinic acetylcholine (α7nACh) receptors, result in cognitive impairments and alterations in sleep-wake behavior. Specifically, KYNA negatively impacts rapid eye-movement (REM) sleep and increases wakefulness. The goals of the present project were to determine the impact of a dose response (0 µM, 1 µM, 3 µM, 10 µM; dissolved in PBS) elevation of KYNA locally in the brain. Wistar rats (N=10 female, …

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …

Caroliniana Columns - Spring 2025, University Libraries--University Of South Carolina

University South Caroliniana Society Newsletter - Columns

Have Digital Exhibit, Will Travel: “Forest to Furniture” featured at Sumter Museum in early 2025 … p.3

Officers at War: Rethinking Southern Masculinity, Honor, and Violence in the Civil War Era / Dr. Patrick F. Doyle … p.10

Researching Politics, Finance, and Agricultural Subsidies in the Jim Crow Era / Robert Ferguson … p.14

The Unsung Heroes of History / Beth Bilderback … p.16

Primary Sources: Authors Rely on SCL Holdings for Their Research … p.20

The Cost of the Vote: George Elmore and the Battle for the Ballot … p.20

Empowering Communities: How Electric Cooperatives Transformed Rural South Carolina …

Standardizing Heart Failure Discharges: Reducing 30-Day Readmission Rates, Angela Keziah

Doctor of Nursing Practice Scholarly Projects

Problem Statement: Patients readmitted with heart failure (HF) suffer increased mortality, reduced quality of life, and heightened medical expenses, though most readmissions are preventable with a consistent HF discharge regimen.

Purpose: To determine if a consistent HF discharge regimen using an evidence-based HF discharge checklist tool, including standardized HF education and a scheduled follow-up appointment with their cardiologist within 7-10 days post-discharge, impacted HF 30-day readmission rates.

Methods: An evidence-based HF discharge checklist tool was placed on participants’ charts on the Progressive Care Unit (PCU) and utilized by the PCU nurses to standardize HF discharges.

Inclusion Criteria: The study included …

Evaluating The Effectiveness Of A Behavioral Emergency Response Team In An Emergency Department, Kim Jai

Doctor of Nursing Practice Scholarly Projects

Problem Statement: The increasing incidence of occupational workplace violence (OWPV) in hospitals, especially in emergency departments (EDs), has become a significant concern in the United States. Given the increasing risk of the occurrence of workplace violence (OWPV) from patients and family members, hospitals have instituted the Behavioral Emergency Response Team (BERT) protocol, comprising trained staff members with expertise in acute psychiatric disorders and de-escalation techniques for managing assaultive behaviors.

Purpose: Evaluate a Behavioral Emergency Response Team (BERT) protocol implemented in an emergency department and make recommendations for improvement.

Methods: Using the Centers for Disease Control and Prevention's Logic Model, this …

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …