Digital Commons Network^™

Age-Dependent Increase In Tyrosine Level Depletes Tyrosyl-Trna Synthetase And Causes Neuronal Oxidative Dna Damage In Alzheimer’S Disease, Megha Jhanji

Theses and Dissertations

Alzheimer’s disease (AD) is the most common form of dementia, and it currently affects more than 50 million people worldwide. Much of the population develop late-onset AD after 65 and constitute more than 95% of the cases. Currently, there is no definitive cure or way to slow down the progression of this disease that addresses the neurodegeneration and loss of cognitive functions. Although the underlying cause of AD is still unknown, the “amyloid cascade hypothesis” attributed it to the aggregation of amyloid beta (AU+03B2) peptides and has been the focus for targeting most disease-modifying drugs in clinical trials. However, emerging …

Puerto Ricans And Mexican Immigrants Differ In Their Psychological Responses To Patterns Of Lifetime Adversity, Daniel K. Cooper, Mayra Bámaca-Colbert, Eric K. Layland, Emily G. Simpson, Benjamin L. Bayly

Faculty Publications

Background Puerto Ricans and Mexican immigrants are often exposed to multiple types of adversity across their lifetime (e.g., maltreatment, household dysfunction, discrimination) and this exposure can increase the risk for adult mental health problems. Purpose The objective of this study was to (a) identify subgroups of individuals exposed to unique combinations of childhood adversity and lifetime discrimination among Puerto Ricans and Mexican immigrants, and (b) compare the prevalence of mental health problems across different risk profiles. Method We used existing data from the HCHS/SOL Sociocultural Ancillary Study. Participants included Puerto Rican (N = 402) and Mexican adults (N = 1351) …

Marginally Interpretable Models And Multilevel Models For Quantile Regression With Random-Effects, Nahid Sultana Sumi

Theses and Dissertations

The quantile regression model is an active area of statistical research that has received a lot of attention. This complements the most widely used statistical tool, that is, mean regression analysis. Quantile regression analysis It has become more flexible because of its properties that include no assumption on the distribution of the response variable, equivalent to monotone transformations, and robustness to outliers. However, regression analysis offers methodological challenges if the observations are not independent. Cluster, multilevel, and repeated measures (longitudinal data) designs introduce such dependence. The correlation between observations on the same units or clusters should be accounted for to …

Secondary Administrators’ Perspectives On Their Involvement In And Barriers To Supporting Secondary Transition Programs For Students With Disabilities, Dottie H. Brown

Theses and Dissertations

To address disparities in post-school outcomes for students with disabilities, federal legislation mandates appropriate education programs to include transition planning and programs for students with disabilities. Because administrators are held responsible for ensuring appropriate educational programs for all learners including those with disabilities, it is important to understand their perspectives on secondary transition; however, research on administrators’ involvement in secondary transition activities is limited. Using a single-state survey, this study examined the perspectives of secondary school administrators on their involvement and engagement in providing effective transition programs and services for students with disabilities and their perceptions of barriers to providing …

Middle And High School Experiences That Lead First-Generation College Students To Select A Stem Major, James A. Byrum

Theses and Dissertations

Careers in science, technology, engineering, and mathematics (STEM) fields are increasing but the number of qualified individuals to fill these positions are not meeting the demand. One way to increase the number of qualified STEM employees is to garner the interest of students from underrepresented groups in the STEM fields. One of these underrepresented groups are first generation college students (FGCS). Understanding what experiences led FGCS to pursue a degree in a STEM field may help attract more students to STEM and help meet the demand of filling future STEM jobs.

In this study, FGCS in the Opportunity Scholars Program …

An Annotated Bibliography Of Flute Repertoire By Iranian Female Composers, Roya Farzaneh

Theses and Dissertations

Compositions by Iranian female composers have rarely been explored or documented. The purpose of this research is to create an annotated bibliography of works by Iranian female composers written for flute. This document will serve as a reference of flute literature for scholars, teachers, and performers to encourage the performance of music composed by Iranian women. Through this research, I hope to increase the exposure of these compositions and amplify interest in performing works written by underrepresented composers.

The annotated bibliography lists information about the repertoire including instrumentation, compositional year, length of piece, publishing, available recordings, commission information, a pedagogical …

Sex Differences And Neuroimmune Effects Of Microglial Response In The Mesolimbic Reward Pathway In Nicotine Substance Use Disorder, Erin Leigh Anderson

Theses and Dissertations

Smoking remains the leading cause of morbidity and mortality in the United States, with less than 5% of smokers attempting to quit succeeding. This is due to the unpleasant withdrawal symptomology, which includes affective symptoms, such as irritability, weight gain, anxiety, and severe craving among others, as well as the cognitive effects, such as difficulty concentrating. This low smoking cessation success rate is also thought to be due to the long-lasting sensitization of nicotinic acetylcholine receptors (nAChRs) leading to long-term neuroadaptations in the brain’s reward system and alterations in synaptic plasticity that occur following chronic nicotine exposure and withdrawal. Glial …

Hear My Voice: Qualitative Studies To Explore What Empowers Patients To Talk With Their Doctor And Participate In Making Health Care Decisions, Alicia Marie Oostdyk

Theses and Dissertations

Patients with fibromyalgia are faced with many decisions throughout the process of seeking and obtaining health care. For patients to feel empowered to take action, it is essential they feel as if they can play a role in making decisions up to their desired level of participation. However, it is unclear what constitutes empowerment in shared decision making between patients and providers. For patients with fibromyalgia, who deal with complex symptomology and individualized treatment choice, it is important to know what makes them feel empowered to participate in care. The objective of this dissertation is to create a patient-centered definition …

The Role Of The School-Based Speech-Language Pathologist In The Identification, Assessment, And Remediation Of Dyslexia In Secondary Students, Lisa Marie Alves

Theses and Dissertations

The purpose of this mixed methods action research study was to increase the awareness and knowledge of secondary school professionals on dyslexia, including the role of the school-based speech-language pathologist. Two research questions guiding the quantitative data collection centered on the impact of a PowerPoint dyslexia training on the participants' knowledge and attitudes about dyslexia in the schools. In addition, two qualitative research questions guided the study involving the participants’ perceptions of the role of speech-language pathologists in a dyslexia protocol, and how to implement a dyslexia protocol in secondary-level schools. The results of the study indicate that the training …

The Road Home Program: An Efficient Model Of Ptsd Treatment In Veterans, Alexandra J. Fischer, Brian J. Klassen, Rhea A. Merck

Senior Theses

This thesis details my experiences at Rush University’s Road Home Program during the summer of 2021. The Road Home Program is an intensive treatment program for veterans suffering from PTSD. It is unique from conventional PTSD treatments in that it provides the equivalent of six months of treatment in just two weeks. The Road Home Program approaches PTSD in a comprehensive way by implementing a variety of therapies and supplemental treatments to veterans. These therapies include Cognitive Processing Therapy (CPT), Mindfulness Based Resiliency Training (MBRT), Dialectical Behavioral Therapy (DBT), and Art Therapy. The supplemental treatments include cognitive seminars, acupuncture, and …

The Role Pde11a4 Signaling And Compartmentalization In Social Behavior, Kaitlyn Pilarzyk

Theses and Dissertations

People tend to be social by nature. Being socially connected not only helps people live longer and healthier lives, but being an engaged and contributing member of society strengthens our communities overall. Maintaining intact social behaviors is key to maintaining this wellbeing, with disruptions negatively affecting both mental and physical health. Indeed, social isolation and feelings of loneliness can significantly increase a person’s risk of premature death, heart disease, and stroke as well as depression, anxiety, suicide, and dementia. Maintaining the ability to create and store social memory with age is, therefore, key to maintaining proper social behaviors. Unfortunately, individuals …

Impact Of Acetylcholine On Amygdala Network Oscillations, Joshua Xavier Bratsch-Prince

Theses and Dissertations

The ability to appropriately respond to and store memories of emotionally salient events is a critical feature of survival. The basolateral amygdala (BLA) is a temporal lobe structure that is essential in mediating emotional behaviors, learning, and memory. Important to circuit function are synchronized neuronal oscillations. Different oscillatory signatures are implicated in mediating different aspects of behavior and learning and memory processes: theta frequency (3-12 Hz) oscillations represent “online” states and are important for information encoding and learning, and sharp wave ripples (SWRs) represent more “offline” states that are important for the consolidation of memory. In the BLA, both of …

Advancing Knowledge Of Exercise As A Therapeutic Management Strategy For Women With Polycystic Ovary Syndrome, Pamela J. Wright

Theses and Dissertations

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among premenopausal women with a prevalence that ranges 15-21%. The estimated financial burden in the United States for evaluating and treating premenopausal women with PCOS was over $8 billion in 2020. PCOS etiology is complex and poorly understood, as is the optimal treatment and management. Endocrine Society Clinical Practice Guidelines recommend exercise as first-line treatment. Yet, the optimal exercise type and “dosing” are not defined. As last reported for women with PCOS, less than 60% are regularly physically active and more than 25% are sedentary. Additionally, little to no published data …

Composition, Context, And Community Integration: Evaluating The Relative Strength Of Environmental Factors On Mental Health Outcomes Using A Social Ecology Model, Douglas John Archie Iii

Theses and Dissertations

The relationship between environmental factors and individual health outcomes has historically been a major area of interest for multiple scientific disciplines. However, the specific environmental factors relevant for describing this relationship and effective measuring methods are unclear. One approach that may assist in addressing these issues is by analyzing this relationship using a comprehensive theoretical framework. This study used a social-ecological model first proposed by Moos and colleagues (Insel & Moos, 1974: Moos & Moos, 1976) to investigate connections between environmental factors and mental health recovery outcomes of psychiatric distress, management of mental health symptoms, and recovery-oriented behavior. A series …

Operationalizing And Measuring High-Quality Instructional Practice – A Theoretical And Empirical Perspective, Genine L. Blue

Theses and Dissertations

This multiple manuscript dissertation offers a cohesive set of research studies curated to address three topics related to how high-quality instructional practice (HQIP) is defined, measured and ultimately connected to student engagement and achievement. Grounded in Benson’s (1998) framework of construct validation, this line of inquiry outlines (i) a well-articulated theoretical domain to make clear the substantive nature of HQIP as a multidimensional latent construct (e.g., substantive stage); (ii) the initial phases of an ongoing, iterative process consisting of empirical analyses designed to continuously build understanding around the structural nature of the observed variables selected to define construct’s empirical domain …

School Psychologists’ Involvement In Transition Programming, Valerie Bell

Theses and Dissertations

This study examined the extent school psychologists reported pre-service training programs addressed involvement in transition programming (e.g., planning, monitoring, and evaluation); their involvement in it; their desire to be involved in transition; possible factors influencing school psychologists’ involvement in it; and if pre-service and professional training in transition affects school psychologists’ involvement and perceptions of their role in the process. Four hundred-fifteen respondents completed and anonymous, online survey. Results indicated participants had not received pre-service training or professional development related to transition; they were rarely or never involved in transition at the elementary, middle, and/or high school levels, although they …

Develop Or Diminish? An Exploration Of Adolescent Athlete Flow Experiences, Hayes Mayfield Bennett

Theses and Dissertations

The concept of flow was birthed from positive psychology specifically to uncover individuals’ most positive experiences and “understand the roots of happiness” (Csikszentmihalyi, 2004). Because of the nature of flow experiences, individuals continually seek out opportunities to have more of these experiences (Seifert & Hedderson, 2010; Swann et al., 2018), however, little is known regarding how adolescents experience flow. For early-adolescents (11-14 years old: Holt, 2007), sports represent an environment that often produces physical, psychological, and social benefits (Crane & Temple, 2015), and combats negative factors (Pluhar et al., 2019). Unfortunately, adolescent athletes are particularly vulnerable to burnout and sports …

“Before The World Gets Them”: The Impact Of Racialized Parenting On Black Mothers, Mia Brantley

Theses and Dissertations

This dissertation explores the distinct practices Black women implement to protect their children from both actualized and anticipatory experiences of racism, as well as its effects on their mothering experiences, health and well-being, as well as how they manage the emotional and mental toll of their children’s experiences. Race plays an integral role in shaping mothering practices. More specifically, motherwork examines how Black mothers ensure the physical, mental, and emotional survival of their children in the face of micro-and macro-level structures that perpetuate racism and inequality. However, much is left to explore regarding the interconnectedness between Black women’s motherwork, linked …

Classdojo And The Effects Of Gamification On Student Engagement Within The Third-Grade Art Classroom: An Action Research Study, Amanda Wrenn Brown

Theses and Dissertations

The purpose of this action research was to evaluate the impact of technology integrated gamification strategies on third-grade students’ engagement in an art classroom at an elementary school with a Science, Technology, Engineering, Art, and Math (STEAM) based curriculum. To increase student engagement, educators and evaluators not only need to understand how engagement has been defined, but also how to assess the options for measuring it. Appropriate use of technology and gamification in classrooms may increase aspects of student engagement, evidenced by taking initiative and responsibility for learning, using resources wisely, and having an interest and desire to pursue information …

Helping High School Students Succeed Academically By Meeting Their More Basic Needs, Karen Eyler Martin

Theses and Dissertations

In this action research, I seek to show the connection between breakfast consumption and student academic achievement. Students skip breakfast for a variety of reasons, including not allowing enough time and not having enough resources for it. Others eat what they can obtain, including snack foods that are highly processed. In addition, school districts have gotten away from making their meals from scratch, and instead, use a third-party catering service that often serves food that is cheap and easy to heat up, which often means it is highly processed and does not have the same nutritional content as whole foods. …

Evaluating The Health Impact Of Centeringpregnancy Program Versus Traditional Prenatal Care In Midland Obstetric Clinics And Validating Selected Item On Birth Certificate, Oluwatosin A. Momodu

Theses and Dissertations

The primary focus of this dissertation is to evaluate the health impact of the CenteringPregnancy (CP) program versus traditional prenatal care (TPNC) on important maternal outcomes of pregnancy. This is looked at in two outcomes-gestational weight gain (GWG) and pregnancy induced hypertension (PIH). The specific aims are to examine the: (1) effects of CenteringPregnancy program versus traditional prenatal care on gestational weight gain (GWG); (2) effects of CenteringPregnancy program versus traditional prenatal care on pregnancy induced hypertension (PIH).

Birth certificate (BC) data were linked to hospital discharge records of women who delivered in midland’s obstetric clinics of South Carolina between …

Social-Motivational Influences On Physical Activity Engagement For Adolescent Girls, Mariajosé Jhamira Paton

Theses and Dissertations

Rates of youth physical activity (PA) drastically decrease during adolescence, with a steeper decline for adolescent girls (Belcher et al., 2010; CDC, 2010). Although afterschool programs (ASPs) have been identified as an ideal context for promoting youth PA, ASPs vary in quality with girls having the highest rates of inactivity (Zarrett et al., 2018). Theory and previous studies have identified social-motivational climate-based factors within ASPs that are critical for promoting adolescents’ PA (Basch, 2011; Eccles et al., 2002; Zarrett et al., 2013, 2015). The present study first examines gender differences in the social-motivational quality of middle school ASPs for promoting …

Physical Activity And Sedentary Behavior During And After Pregnancy And Postpartum Weight Retention, Kaitlyn Taylor Ramey

Theses and Dissertations

INTRODUCTION AND PURPOSE

Pregnancy is associated with increased changes in body weight that can shape long-term health in women. Previous studies have shown that increased prenatal physical activity and decreased sedentary time correlated with less excessive gestational weight gain. Little is known about how leisure time exercise and sedentary behavior affects postpartum weight retention. The aim of our study was to identify how sedentary behavior and leisure time physical activity, both mid-pregnancy and after pregnancy, relate to postpartum weight retention from 6 months to 3 years after childbirth.

METHODS

A total of 79 women who delivered a singleton infant 6-months …

Food Choice Decision-Making Among School-Going Adolescents Amidst The Nutrition Transition In Urban Accra, Ghana, Krystal Krsna Rampalli

Theses and Dissertations

Like many countries of the world, Ghana is experiencing a nutrition transition and rising non-communicable diseases. Adolescents are susceptible to diet-related health risks as they experience significant physical and psychological changes, which are happening in tandem with food environment changes, including widespread proliferation of large portion and package sizes of energy-dense, nutrient-poor foods. Both local and multinational food and beverage companies have encouraged consumption of their products through various marketing tactics targeted directly to adolescents. Some of these tactics include the use of characters or celebrity endorsement, promotional discounts, and appeal to sociocultural values, including messages about body size preferences. …

Supporting The African American Prekindergarten Student Through Standard Academic English Instruction, Trent Gibson Rogerson

Theses and Dissertations

The objective for this research was to determine if prekindergarten African American students would show gains on English language assessments after receiving targeted Standard Academic English instruction. The research question asks, “How can a specialized English language intervention be utilized to identify the strengths and areas of improvement for African American preschool students?” The hypothesis was the students who received targeted instruction in Standard Academic English would perform better on the post-test than on the pre-test given before the instruction period. For this study, eight prekindergarten students were allowed to participate in the research. The students were administered an English …

An Action Research Study Implementing A Livescribe™ Pen And Cornell Note-Taking Strategy In A Personal And Community Health Course To Support Note-Taking And Comprehension Of College Student-Athletes With Learning Disabilities, Ivana Rich

Theses and Dissertations

The purpose of this study was to examine the impact of the Livescribe™ Symphony smartpen and the Cornell note-taking strategy on the lecture comprehension and quality of written notes of college student-athletes with learning disabilities. To explore educational tools and strategies that can assist students with learning disabilities in overcoming academic challenges, this study focused on three research questions: (1) how does the use of the Cornell note-taking strategy supported with a Livescribe™ pen affect the note-taking quality of student-athletes with learning disabilities (2) how does the use of the Cornell note-taking strategy supported with a Livescribe™ pen affect the …

The Implementation And Impact Of The Leveled Literacy Intervention System On Middle School Students In Special Education, Krystin Mccormick Williams

Theses and Dissertations

The purpose of this mixed-methods action research study was to determine the effects of a direct, individualized, and intensive reading intervention on middle school students with identified learning disabilities in the area of reading. The Leveled Literacy Intervention System was used as the reading intervention in this study. Oral reading fluency and reading comprehension skills were measured, as well as the student participants’ attitude toward reading. Data collection methods included LLI system assessments, district level benchmark reading assessments, and student questionnaires. The teacher-researcher analyzed the data and determined the 18-week LLI intervention had positive impacts on the student participants’ oral …

Music As Complementary And Alternative Medicine (Cam) Therapy: An Exploratory Literature Review, Amy Arlene Clary

Theses and Dissertations

Complementary and Alternative Medicine (CAM) is a broad term for treatment plans outside of conventional therapy or conventional medicine.1 The National Center for Complementary and Integrative Health (NCCIH) divides CAM therapies into three categories “Natural Products,” “Mind and Body,” and “Other Complementary Health Approaches.” The NCCIH places music in the category “Mind and Body.” This exploratory literature review provides a comprehensive review of the various ways music is being studied for its psychological, sociological, and physiological benefits.

The purpose of this study was to create a comprehensive literature review of music as a CAM therapy. The study codifies a current …

The Impact Of The Teacher-Student Relationship On Students’ Educational Expectations, Amanda Lynn Davis

Theses and Dissertations

Students benefit both academically and psychosocially from close, supportive relationships with their teachers. Students who have close relationships with their teachers tend to adjust better to school, perform better academically, and engage in fewer problem behaviors. These benefits begin as early as preschool and mitigate several barriers to educational success for students from low-resource environments. However, it is unclear how changes in these relationships over time differentially influence positive outcomes. In this study, I test how changes in relationship closeness between students and teachers influence students’ expectations about future educational achievement. I also test how the strength of this association …

Planning And Teaching For Student Learning In Mathematics: How Graduate Student Instructors Develop And Implement Instruction, Jennifer S. Crooks-Monastra

Theses and Dissertations

The purpose of this study was to explore undergraduate mathematics teaching from the perspective of a graduate student serving as a first-time precalculus instructor of record. A multiple case study was designed to follow three mathematics graduate student instructors (MGSIs) through one semester of teaching to understand their goals for student learning, efforts to achieve these goals, influences on planning, and to identify challenges they encountered. For each MGSI, data collection included four interviews, three observations of teaching, weekly journal entries, and written assignments from a pedagogy course. A focus group, field notes from the pedagogy course, audio from mentor …