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Full-Text Articles in Entire DC Network
On-Orbit Correction Of Ecostress Radiances By Comparison With Iasi Hyperspectral Sounders, David S. Wethey, Sarah A. Woodin, Jorge Vazquez-Cuervo
On-Orbit Correction Of Ecostress Radiances By Comparison With Iasi Hyperspectral Sounders, David S. Wethey, Sarah A. Woodin, Jorge Vazquez-Cuervo
Faculty Publications
Radiance data from ECOSTRESS (ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station), which is the first of a planned virtual constellation of wide-swath ultra-high-resolution thermal satellites, were used to test the concept of on-orbit cross-calibration based on the Global Space-based Inter-Calibration System (GSICS) with the Infrared Atmospheric Sounding Interferometer (IASI) as the reference. Validation of the results was performed using comparisons of corrected ECOSTRESS radiances with strictly independent data from IASI and the Cross-Track Infrared Sounder (CrIS) and with RTTOV radiative transfer simulations of clear-sky observations in iQuam (the NOAA in situ sea surface temperature quality monitor database). ECOSTRESS has …
Artemisinin Partial Resistance Mutations In Zanzibar And Tanzania Suggest Regional Spread And African Origins, 2023, Sean V. Connelly, Julia G. Muller, Mohamed Ali, Billy E. Ngasala, Wahida Hassan, Bakari Mohamed, Kyaw L. Thwai, Jacob M. Sadler, Jacob Marglous, Abebe A. Fola, Abdallah Zacharia, Shija J. Shija, Safia Mohammed, Dominick C. Msolo, Hamza Said, Editruda E. Peter, Melic Odas, Isaack J. Rutha, Mwanaidi Nwange, Karamoko Naire, Shazia Ruybal-Pesántez, Robert Verity, Rebecca Crudale, Varun Goel, Barbara B. Choloi, Anders Björkman, Jeffrey A. Bailey, Jessica T. Lin, Jonathan J. Juliano
Artemisinin Partial Resistance Mutations In Zanzibar And Tanzania Suggest Regional Spread And African Origins, 2023, Sean V. Connelly, Julia G. Muller, Mohamed Ali, Billy E. Ngasala, Wahida Hassan, Bakari Mohamed, Kyaw L. Thwai, Jacob M. Sadler, Jacob Marglous, Abebe A. Fola, Abdallah Zacharia, Shija J. Shija, Safia Mohammed, Dominick C. Msolo, Hamza Said, Editruda E. Peter, Melic Odas, Isaack J. Rutha, Mwanaidi Nwange, Karamoko Naire, Shazia Ruybal-Pesántez, Robert Verity, Rebecca Crudale, Varun Goel, Barbara B. Choloi, Anders Björkman, Jeffrey A. Bailey, Jessica T. Lin, Jonathan J. Juliano
Faculty Publications
Artemisinin partial resistance, driven by Plasmodium falciparum K13 mutations, threatens malaria control. Zanzibar is vulnerable to artemisinin partial resistance spread but lacks recent molecular surveillance. We sequenced samples in Zanzibar and mainland Tanzania collected from 2022 to 2024. K13 mutations were found in 2 of 1440 participants (P441L, A675V) in Zanzibar and 6 of 3762 (R561H, P441L) in mainland Tanzania. Based on whole genome sequencing data, K13 mutations appear to be of African origin with regional spread. Frequent parasite importation appears to maintain partner drug mutation frequencies similar to the mainland, where artemether-lumefantrine selects for mutations favoring artesunate-amodiaquine sensitivity. Ongoing …
Ichps Special Issue Introduction, Donna Coffman, Recai M. Yucel
Ichps Special Issue Introduction, Donna Coffman, Recai M. Yucel
Faculty Publications
No abstract provided.
Integrating Future Factory-To-Factory (F2f) Manufacturing Through System Of Systems Engineering (Sose): A Framework For Capability Beyond Constituent Systems, Polinpapilinho F. Katina, Hengtao Tang Ph.D., Anouar Hallioui
Integrating Future Factory-To-Factory (F2f) Manufacturing Through System Of Systems Engineering (Sose): A Framework For Capability Beyond Constituent Systems, Polinpapilinho F. Katina, Hengtao Tang Ph.D., Anouar Hallioui
Faculty Publications
System of Systems Engineering (SoSE) is an emerging discipline focused on the design, integration, and evolution of metasystems—composed of multiple autonomous yet interdependent systems. These systems of systems (SoS) offer capabilities that exceed those of any individual constituent systems by enabling synergistic coordination, interoperability, and dynamic adaptation across diverse operational contexts. This study pursued three primary objectives: (i) to examine the role of integration in enabling emergent capabilities beyond those of individual systems, (ii) to explore SoSE as a framework for orchestrating Future Factory-to-Factory (F2F) Manufacturing, and (iii) to assess the implications of SoSE to address volatile, uncertain, complex, and …
Intravascular Ultrasound Is More Accurate Than Angiography In Arteriovenous Vascular Access Lesions, James W. Decker, Dima Banihani, Curtis Honshideler, Saran Lotfollahzadeh, David Jasen Wu Wong, Alik Farber, Jeffrey J. Siracuse, Najia Idrees, Laura Dember, Mohammad Bader, Suvranu Ganguli, Vijaya Kolachalama, Tarek Shazly
Intravascular Ultrasound Is More Accurate Than Angiography In Arteriovenous Vascular Access Lesions, James W. Decker, Dima Banihani, Curtis Honshideler, Saran Lotfollahzadeh, David Jasen Wu Wong, Alik Farber, Jeffrey J. Siracuse, Najia Idrees, Laura Dember, Mohammad Bader, Suvranu Ganguli, Vijaya Kolachalama, Tarek Shazly
Faculty Publications
Background:
Conventional angiography remains the standard diagnostic modality for arteriovenous (AV) access dysfunction in hemodialysis patients, but its geometric accuracy is limited. Intravascular ultrasound (IVUS) offers superior lesion detection, yet its absolute measurement accuracy remains uncertain. Using three-dimensional (3D) printed vascular conduits as reference standards, we assessed the accuracy of IVUS versus angiography, hypothesizing that complex conduit geometry, quantified by Gaussian curvature, would exacerbate angiographic error.
Methods
Clinically relevant AV access geometries were modeled with computer-aided design (CAD) and fabricated using 3D printing. Lumen diameters were measured by contrast angiography and IVUS and compared with CAD dimensions. Conduit geometry was …
Us Federal Budgets And Federal Employee Job Satisfaction, Nathan Favero, Carla Flink, Tingli Qu
Us Federal Budgets And Federal Employee Job Satisfaction, Nathan Favero, Carla Flink, Tingli Qu
Faculty Publications
Researchers have long studied how organizational budgets relate to performance, but how do employees themselves experience the effects of budgetary decisions? Given widespread attention to political dysfunction in US federal budgeting, conventional wisdom holds that employees are negatively affected by budgetary uncertainty (volatility, delays, and stop-gap measures). We test how budget size and uncertainty are associated with US federal employee attitudes using survey and archival data from 2005 to 2020. Results provide some evidence that employee job satisfaction improves with enhanced funds, but there is little to no support for the notion that budgetary uncertainty influences federal employees' job satisfaction.
Asian Reference Values For Handgrip Strength, Gait Speed, Five-Times-Sit-To-Stand Test, Muscle Mass And Calf Circumference, Jozo Grgic, Siew Ling Tey, Dieu Thi Huynh, Yen Ling Low, Zeljko Pedisic, Nina Schaller, Vanessa Kristina Wazny, Weilan Wang, Yasuhiko Saito, Ravindra P. Rannan-Eliya, Hala Ghattas Ph.D., Monique Chaaya, Carlos Mendes De Leon, Preeti Gupta, Ecosse L. Lamoureux, Mythily Subramaniam, Edimansyah Abdin, Rahul Malhotra, Angelique Chan, Bayasgalan Tumenbayar, Et. Al.
Asian Reference Values For Handgrip Strength, Gait Speed, Five-Times-Sit-To-Stand Test, Muscle Mass And Calf Circumference, Jozo Grgic, Siew Ling Tey, Dieu Thi Huynh, Yen Ling Low, Zeljko Pedisic, Nina Schaller, Vanessa Kristina Wazny, Weilan Wang, Yasuhiko Saito, Ravindra P. Rannan-Eliya, Hala Ghattas Ph.D., Monique Chaaya, Carlos Mendes De Leon, Preeti Gupta, Ecosse L. Lamoureux, Mythily Subramaniam, Edimansyah Abdin, Rahul Malhotra, Angelique Chan, Bayasgalan Tumenbayar, Et. Al.
Faculty Publications
Background:
Handgrip strength, gait speed, Five-Times-Sit-to-Stand Test (FTSST) performance, skeletal muscle mass and calf circumference are important health outcomes, particularly useful for diagnosing sarcopenia. The aim of this study was to establish reference (normative) values for handgrip strength, gait speed, FTSST performance, skeletal muscle mass and calf circumference by pooling individual participant data from national cohorts in Asia.
Methods:
We conducted a pooled analysis of individual participant data from 20 national cohorts representing 12 Asian countries (China, India, Indonesia, Israel, Japan, Lebanon, Malaysia, Mongolia, Philippines, Republic of Korea, Singapore and Sri Lanka). We included cohorts with data on at least …
Group Antenatal Care Model As An Innovative And Sustainable Maternal And Child Health Service Delivery In A Northern Nigerian State, Pius I. Christopher-Izere, Abiola Ajibola, Abimbola Phillips, Dorcas Magbadelo, Ibidun Jolaoso, Obioma Azurunwa, Francis Ogirima, Collins Imarhiagbe, Anthony Onwuegbusi, David Udanwojo, Emmanuel Udeh, Victor Obagunlu, Adebola Adekogbe, Sunday Joseph, Hamza Abubakar, Neyu Iiyasu, Adetosoye Adebanjo, Barlarbe Gaya, Olayiwola Jaiyeola, Damilola Olaniyan, Bankole Olatosi Ph.D., Deborah Lynn Billings Ph.D., Et. Al.
Group Antenatal Care Model As An Innovative And Sustainable Maternal And Child Health Service Delivery In A Northern Nigerian State, Pius I. Christopher-Izere, Abiola Ajibola, Abimbola Phillips, Dorcas Magbadelo, Ibidun Jolaoso, Obioma Azurunwa, Francis Ogirima, Collins Imarhiagbe, Anthony Onwuegbusi, David Udanwojo, Emmanuel Udeh, Victor Obagunlu, Adebola Adekogbe, Sunday Joseph, Hamza Abubakar, Neyu Iiyasu, Adetosoye Adebanjo, Barlarbe Gaya, Olayiwola Jaiyeola, Damilola Olaniyan, Bankole Olatosi Ph.D., Deborah Lynn Billings Ph.D., Et. Al.
Faculty Publications
The maternal and child health situation in developing countries remains critical and deeply concerning, These regions account for 99% of global maternal and under-five deaths. In Nigeria, uptake of critical life-saving maternal, neonatal and child health (MNCH) services, delivered through antenatal care (ANC), are sub-optimal, leading to poor outcomes. Group antenatal care (G-ANC) is an evolving antenatal care delivery model in low and medium-income countries. G-ANC models can improve quality and uptake of maternal health services.G-ANC model was implemented across 255 primary health facilities (PHFs) to ensure pregnant women receive components of a well-defined package of MNCH services at regular …
Sexual And Gender Minority Nurses’ Minority Stress In The Workplace: A Scoping Review, Justin Chavis, Robin Dawson Phd, Rn, Cpnp-Pc, Faan, Liam C. Hein
Sexual And Gender Minority Nurses’ Minority Stress In The Workplace: A Scoping Review, Justin Chavis, Robin Dawson Phd, Rn, Cpnp-Pc, Faan, Liam C. Hein
Faculty Publications
Background
Sexual and gender minority nurses are underrepresented in the literature, which perpetuates the invisibility of their unique workplace experiences.Purpose
This scoping review examined the body of literature on sexual and gender minority nurses’ workplace experiences from the context of minority stress.Methods
The Arksey and O’Malley Framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) informed this scoping review. Initial database search identified 1,846 records, which then underwent title and abstract screening (n = 1,721), and assessment for full text review (n = 56). Full review and analysis of …Uav-Deployable Open-Source Sensor Nodes For Spatial And Temporal In Situ Water Quality Monitoring And Mapping, Matthew Burnett, Mohamed Abdelwahab, Joud N. Satme, Austin Downey, Gabriel Barahona Smith, Antonio Fonce, Jasim Imran
Uav-Deployable Open-Source Sensor Nodes For Spatial And Temporal In Situ Water Quality Monitoring And Mapping, Matthew Burnett, Mohamed Abdelwahab, Joud N. Satme, Austin Downey, Gabriel Barahona Smith, Antonio Fonce, Jasim Imran
Faculty Publications
Cost efficient, spatially resolved water quality monitoring is essential for managing pollution and protecting aquatic ecosystems. This study presents a low-cost (approximately USD 200), open-source, unmanned aerial vehicle (UAV)-deployable in situ sensor node for real-time assessment of surface-water conditions. The system integrates sensors for pH, turbidity, temperature, and total dissolved solids (TDSs), with onboard data logging and real-time clock (RTC) synchronization. Bench validation of the sensor package yielded mean absolute percentage errors of 1.34% for pH, 5.23% for TDS, and 0.81% for temperature, and the device operated continuously for 42 h. Field deployment demonstrated its ability to resolve spatial gradients, …
Structural And Mechanical Properties Facilitate Shock Wave Damping By Helmet-Like Orbital Hoods In Snapping Shrimp, Mia Kazel, Rebekah E. Cammack, Alexandra C.N. Kingston, Ahmed A. Alshareef, Tarek Shazly, Daniel Isaac Speiser
Structural And Mechanical Properties Facilitate Shock Wave Damping By Helmet-Like Orbital Hoods In Snapping Shrimp, Mia Kazel, Rebekah E. Cammack, Alexandra C.N. Kingston, Ahmed A. Alshareef, Tarek Shazly, Daniel Isaac Speiser
Faculty Publications
Snapping shrimp damp the shock waves they produce and use as weapons with a helmet-like structure termed the orbital hood. Here, we ask how structural and material properties contribute to shock wave damping by orbital hoods in Alpheus heterochaelis. Using tensile mechanical testing, we find orbital hoods are approximately half as stiff as carapace and have twice the capacity for viscous energy dissipation. Microstructural features probably contribute to tissue-specific mechanical properties: the endocuticles of orbital hoods have almost twice as many lamellae as those of carapaces despite being half as thick, suggesting a mechanism for enhanced material mobility underlying …
Equal Chances Or Fewer Victims? Moral Judgments In Autonomous Vehicle Dilemmas, Alexander Matros, Eren Bilen, Leonid Matros
Equal Chances Or Fewer Victims? Moral Judgments In Autonomous Vehicle Dilemmas, Alexander Matros, Eren Bilen, Leonid Matros
Faculty Publications
We examine the moral dilemma of how autonomous vehicles (AVs) should be programmed to act in unavoidable crash scenarios involving trade-offs between saving one life and saving many. We report results from three experimental studies that investigate individuals’ preferences over alternative AV decision rules in stylized crash scenarios. Across designs, we find robust support for a probabilistic decision rule that assigns passengers and pedestrians equal ex ante chances of survival (a 50:50 rule). This preference persists across different framings and remains salient even when additional probabilistic options are introduced.
Striation Characteristics In Atmospheric Pressure Ac-Driven Glow Discharge Operating In Monoatomic Gas, Ayuob K. Alwahaibi, Sang Hee Won, Tanvir Farouk
Striation Characteristics In Atmospheric Pressure Ac-Driven Glow Discharge Operating In Monoatomic Gas, Ayuob K. Alwahaibi, Sang Hee Won, Tanvir Farouk
Faculty Publications
Striation in an atmospheric pressure AC-driven helium glow discharge operating at 25 kHz is experimentally characterized. Striation behavior is characterized by the visualization of discharges and voltage–current measurements over a range of plasma power. Voltage–current characteris tics reveal that striations form in the “normal” glow regime of operation, with a higher number of strata at low current, diminishing as dis charge current increases. The relative differences and similarities in the striation patterns during the positive and negative cycles are identified. High-speed imaging shows the striations to be traveling in time—“moving striations.” The spatial luminosity of the striations is tracked over …
The Structure, Pathogenesis, And Inhibition Of The P53-Mdm2 Pathway, Amanda L. Brown, Xiaoying Lian, Qian Wang
The Structure, Pathogenesis, And Inhibition Of The P53-Mdm2 Pathway, Amanda L. Brown, Xiaoying Lian, Qian Wang
Faculty Publications
The p53 tumor suppressor protein plays a central role in maintaining genomic stability by regulating cell cycle arrest, apoptosis, and DNA repair under cellular stress. Mouse double minute 2 (MDM2), an E3 ubiquitin ligase, negatively regulates p53 via direct binding and proteasomal degradation. Overexpression or amplification of MDM2 can disrupt this pathway and promote tumorigenesis, even in cancers with wild-type p53. This review outlines the structural features of MDM2, particularly its N-terminal hydrophobic pocket and C-terminal RING domain, and their roles in p53 regulation. We further examine the pathological effects of MDM2 dysregulation and SNPs linked to increased cancer risk. …
Individual Characteristics And National Income Modify The Association Between Cognitive Social Capital And Food Insecurity: Evidence From The Gallup World Poll, 2014–2021, Sejla Isanovic, Kegan O'Connor, Audrey L. Richards, Edward A. Frongillo Jr. Ph.D.
Individual Characteristics And National Income Modify The Association Between Cognitive Social Capital And Food Insecurity: Evidence From The Gallup World Poll, 2014–2021, Sejla Isanovic, Kegan O'Connor, Audrey L. Richards, Edward A. Frongillo Jr. Ph.D.
Faculty Publications
Background: Food insecurity affects >2.4 billion people globally and persists across income levels. Characteristics such as low income, low education, and unstable employment do not fully explain this persistence. Social resources embedded in networks, specifically cognitive social capital involving trust, reciprocity, and support, may offset constraints and buffer characteristics associated with a higher probability of food insecurity.
Objectives: This study examined whether social capital was associated with a lower probability of food insecurity and whether this as sociation varied by individual characteristics and country contexts, consistent with buffering and compensation.
Methods: Data were drawn from the Gallup World Poll (2014–2021), …
Understanding The 2016–2018 Freshening Dynamics Of The Beaufort Gyre Through Observations And Model Reanalysis, Christina Gregory, Ganesh Gopalakrishnan, Bulusu Subrahmanyam
Understanding The 2016–2018 Freshening Dynamics Of The Beaufort Gyre Through Observations And Model Reanalysis, Christina Gregory, Ganesh Gopalakrishnan, Bulusu Subrahmanyam
Faculty Publications
The Beaufort Gyre (BG) in the Arctic Ocean has experienced rapid changes in losing extensive amounts of sea-ice and undergoing freshening over the past few decades. In this study, we highlight important recent changes in BG’s surface circulation, and its impact on freshwater (FW) fluxes and freshwater content (FWC) and draw attention to the critical importance of continuous monitoring of BG dynamics. Using satellite observations of the upper ocean state and ocean and atmospheric reanalysis, here we attempt to understand the anomalous behavior of BG dynamics over the past few decades. In recent years, atmospheric forcings increasingly influenced important judications …
Obesogenic Behaviors During Structured Periods Among Children And Adolescents With Intellectual And Developmental Disabilities: A Systematic Review And Meta-Analysis, Keagan P. Kiely, Keith Brazendale, Mckenna Hill, Sarah Burkart, Michael Beets Med, Mph, Phd, Elizabeth L. Adams Phd, Bridget Armstrong, Christine St. Laurent, Abigail L. Hogan Ph.D., James W. White Iii, Olivia Finnegan, Joshua Culverhouse, Anthony Holmes, Robert Glenn Weaver Med, Phd
Obesogenic Behaviors During Structured Periods Among Children And Adolescents With Intellectual And Developmental Disabilities: A Systematic Review And Meta-Analysis, Keagan P. Kiely, Keith Brazendale, Mckenna Hill, Sarah Burkart, Michael Beets Med, Mph, Phd, Elizabeth L. Adams Phd, Bridget Armstrong, Christine St. Laurent, Abigail L. Hogan Ph.D., James W. White Iii, Olivia Finnegan, Joshua Culverhouse, Anthony Holmes, Robert Glenn Weaver Med, Phd
Faculty Publications
Background:
Children and adolescents with intellectual and developmental disabilities (IDD) are at greater risk for obesity and poor obesogenic behaviors (e.g., physical activity, screen time, diet, sleep) than their typically developing counterparts. The Structured Days Hypothesis (SDH) suggests that in typically developing children and adolescents, obesogenic behaviors worsen during periods of reduced structure (e.g., weekend or summer vacation). However, children and adolescents with IDD have unique factors that may alter how structure (i.e., pre-planned, segmented, adult supervised, out-of-home programs) influences obesogenic behaviors. Therefore, the objective of this systematic review and meta-analysis is to examine obesogenic behaviors during periods of more …
Ecologic Factors Contributing To West Nile Virus Hyperendemicity In Central South Carolina: An Integrated Vector–Human–Environmental Study, Elba S. Fridriksson, Ahayla Muraleedharan, Kyndall C. Dye-Braumuller, Madeleine M. Meyer, Kia Zellars, Hiuxuan Li, Melissa S. Nolan Ph.D., Mph
Ecologic Factors Contributing To West Nile Virus Hyperendemicity In Central South Carolina: An Integrated Vector–Human–Environmental Study, Elba S. Fridriksson, Ahayla Muraleedharan, Kyndall C. Dye-Braumuller, Madeleine M. Meyer, Kia Zellars, Hiuxuan Li, Melissa S. Nolan Ph.D., Mph
Faculty Publications
West Nile virus (WNV) is an endemic arboviral infection in the United States that has undergone phyloge-netic evolution since its introduction 25 years ago. An integrated vector–human–pathogen study was conducted in the summer of 2023 to unearth contemporary Culex quinquefasciatus habitat patterns and human transmission spillover foci in South Carolina, a state with historically little WNV data. A serosurvey revealed WNV seroprevalence 10 times the national average (22% versus 2%, respectively), with unusual epidemiologic risk factors. Female Culex quinquefas-ciatus WNV positivity was low (2.7%), with viral phylogenetics 100% homologous to the WN02 clade. Mosquito vectors clustered in affluent urban neighborhoods …
February 4, 2026 Faculty Senate Minutes, University Of South Carolina
February 4, 2026 Faculty Senate Minutes, University Of South Carolina
Faculty Senate
No abstract provided.
Theoretical And Conceptual Approaches To Journalism Education, August E. Grant, Jeffrey S. Wilkinson, G. Nathan Carnes
Theoretical And Conceptual Approaches To Journalism Education, August E. Grant, Jeffrey S. Wilkinson, G. Nathan Carnes
Faculty Publications
Many journalism programs embrace the teaching hospital model because of its practical approach, employing working journalists as journalism educators. However, critics contend a more conceptual model of journalism education is needed. This essay explores the literature on journalism education models and seeks to integrate the teaching hospital and entrepreneurial journalism approaches with the revised Bloom's Taxonomy and Fink's Taxonomy of Significant Learning. Combined, these models provide a solid theoretical foundation for practical, applied journalism education. This essay applies these four models to journalism education, yielding a matrix of dimensions that can guide the creation or modification of curricula as well …
Understanding The Epidemiology Of Malaria In Zanzibar Through Molecular And Serological Analysis Of Samples Collected During Reactive Case Detection, Vanrun Goel, Wahida Hassan, Caroline Murphy, Barbara B. Choloi, Mohamed Ali, Shija J. Shija, Jeffrey A. Bailey, Anders Björkman, Billey E. Ngasala, Eric Rogier, Jonathan J. Juliano, Jessica T. Lin
Understanding The Epidemiology Of Malaria In Zanzibar Through Molecular And Serological Analysis Of Samples Collected During Reactive Case Detection, Vanrun Goel, Wahida Hassan, Caroline Murphy, Barbara B. Choloi, Mohamed Ali, Shija J. Shija, Jeffrey A. Bailey, Anders Björkman, Billey E. Ngasala, Eric Rogier, Jonathan J. Juliano, Jessica T. Lin
Faculty Publications
Background
The Zanzibar archipelago has been a pre-elimination region for malaria thanks to rigorous control interventions, but recent surges in malaria cases have been observed. The contribution of non-falciparum species to the current malaria situation is unknown.
Method
This study investigates the epidemiology of falciparum and non-falciparum malaria species in Zanzibar. Leveraging plasma extracted from dried blood spots (DBS) collected during reactive case detection (RCD) activities across Unguja island from May 2022 to January 2023, we measured immunoglobulin G (IgG) responses to Plasmodium MSP1-19kD antigens using a multiplex bead-based immunoassay. Additionally, active infections were detected using species-specific real-time PCR.
Results …
Cost-Effectiveness Of Pregabalin, Duloxetine, And Milnacipran Vs Amitriptyline For Moderate To Severe Fibromyalgia, Sarah S. Downen, Hussein M. Farag, Abby Davis, Chijioke M. Okeke, Kenechukwu C. Ben-Umeh, Ismaeel Yunusa Ph.D., Tewodros Eguale
Cost-Effectiveness Of Pregabalin, Duloxetine, And Milnacipran Vs Amitriptyline For Moderate To Severe Fibromyalgia, Sarah S. Downen, Hussein M. Farag, Abby Davis, Chijioke M. Okeke, Kenechukwu C. Ben-Umeh, Ismaeel Yunusa Ph.D., Tewodros Eguale
Faculty Publications
Importance
Fibromyalgia (FM) is a chronic pain condition associated with substantial quality-of-life impairments and economic burden. Although multiple pharmacologic options are recommended in clinical guidelines, the relative cost-effectiveness of off-label amitriptyline compared with FDA-approved treatments remains poorly defined due to a scarcity of direct economic comparisons and the use of heterogenous outcome measures in the extant literature.
Objective
To evaluate the cost-effectiveness of pregabalin, duloxetine, and milnacipran compared with amitriptyline in adults with moderate to severe FM.
Design, Setting, and Participants
Decision analytical model using a Markov cohort state transition model to estimate lifetime costs and quality-adjusted life-years (QALYs) for …
Boronate Esters For The Binding And Detection Of Low Molecular Weight Volatile Amines, Xiaoning Li, James Boyt, Steven Sloope, Luke T. Lackovic, Mark D. Smith, James J. Lavingne
Boronate Esters For The Binding And Detection Of Low Molecular Weight Volatile Amines, Xiaoning Li, James Boyt, Steven Sloope, Luke T. Lackovic, Mark D. Smith, James J. Lavingne
Faculty Publications
Conjugated thiophene-based diboronate esters, 1–4, were synthesized to investigate how substituents on catechol alter the Lewis acidity and accessibility to boron, and influence binding interactions with low molecular weight Lewis basic amines. Crystallographic analysis indicated that both boron centres bind analyte and that Lewis base coordination induces deplanarization of the conjugated system. Spectroscopic studies demonstrate that amine binding disrupts conjugation, producing distinct and reproducible optical responses that depend on analyte basicity and structure, with association constants in organic solvent ranging from 103 to 106 M−1. Quantitative binding analyses indicate strong negative cooperativity between the two boron …
Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment For Solid Tumors, Stephen O'Rourke, Nuo Xu, Hongjun Wang, Hexin Chen
Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment For Solid Tumors, Stephen O'Rourke, Nuo Xu, Hongjun Wang, Hexin Chen
Faculty Publications
The emergence of effective immunotherapies has drastically revolutionized clinical management of many cancer types. Among them, chimeric antigen receptor (CAR)-T cell therapy (CTT), as a groundbreaking approach, has been considered as a “living drug,” displaying unprecedented clinical outcomes with hematological malignancies, including B cell leukemia and lymphomas, and multiple myeloma. Despite the high remission rates and improved survival achieved with hematological cancers, the effectiveness of CTT in solid tumors remains largely unsatisfactory. The efficacy of CTT in solid tumors is significantly challenged by multiple factors, including tumor-antigen heterogeneity, limited T cell trafficking and infiltration, a highly immunosuppressive tumor microenvironment, and …
Biologically-Inspired Multiscale Neuromorphic Architecture, Christian O'Reilly, Ramtin Zand
Biologically-Inspired Multiscale Neuromorphic Architecture, Christian O'Reilly, Ramtin Zand
Publications
This white paper proposes a biologically-inspired multiscale neuromorphic architecture that bridges key gaps between artificial neural networks (ANNs), spiking neural networks (SNNs), and biological neural networks (BNNs). While SNNs offer promising energy efficiency, their broader adoption remains limited by suboptimal performance and the need for novel learning paradigms. To address these challenges, the proposed framework integrates structural and functional principles observed in the brain, including hierarchical organization, sparse and modular connectivity, predictive coding, and diverse neuronal dynamics.
The architecture operates across micro-, meso-, and macro-scales, incorporating neuron-level diversity (e.g., excitatory/inhibitory and principal/support cells), canonical microcircuits (CMCs), and large-scale hierarchical organization. …
The Promise Of Mindfulness-Based Interventions: A Stress-Reduction Strategy For Testicular Cancer Survivors' Health-Related Quality Of Life, Michael J. Rovito, Colin F. Mahony, Kamalie Thomas, Keith Brazendale, Ciaran Fairman Ph.D., Cscs, Cet
The Promise Of Mindfulness-Based Interventions: A Stress-Reduction Strategy For Testicular Cancer Survivors' Health-Related Quality Of Life, Michael J. Rovito, Colin F. Mahony, Kamalie Thomas, Keith Brazendale, Ciaran Fairman Ph.D., Cscs, Cet
Faculty Publications
Background: Testicular cancer (TC) disproportionately affects younger men and carries unique psychosocial and physiological consequences that extend well beyond treatment. Despite favorable survival rates, TC survivors frequently report diminished health-related quality of life (HRQoL). These burdens are often compounded by masculinity-related identity disruptions, fear of recurrence, sexual dysfunction, and a lack of tailored psychosocial support. Existing interventions remain limited, with most programs focused on physical rehabilitation or early detection. Few address the multidimensional stressors that shape the TC survivorship experience.
Aims: This narrative review examines the literature on HRQoL among TC survivors and evaluates the potential of mindfulness-based interventions (MBIs) …
Association Of Body Fatness With Hypertension, Dyslipidemia, And Myocardial Infarction In A Multinational Pooled Cohort, Vivek Kumar Prasad, Chibueze Ogbonnaya, Hannah Oh, Andrew Atkin, Madison Kindred, Min-Jeong Shin, Dahyun Park, Jin Eui Kim, Mike Loosemore, Vartika Saxena, Ryan Porter, Courtney Kipps, Jason Jaggers, Xuemei Sui M.D., M.P.H., Ph.D., Carl J. Lavie, Mark Hamer
Association Of Body Fatness With Hypertension, Dyslipidemia, And Myocardial Infarction In A Multinational Pooled Cohort, Vivek Kumar Prasad, Chibueze Ogbonnaya, Hannah Oh, Andrew Atkin, Madison Kindred, Min-Jeong Shin, Dahyun Park, Jin Eui Kim, Mike Loosemore, Vartika Saxena, Ryan Porter, Courtney Kipps, Jason Jaggers, Xuemei Sui M.D., M.P.H., Ph.D., Carl J. Lavie, Mark Hamer
Faculty Publications
Objective
To investigate the association of dual-energy X-ray absorptiometry–measured body fat percentage (BF%) and trunk fat mass index (TFMI) with hypertension (HTN), dyslipidemia, and myocardial infarction (MI).Methods
The relationship between body fat parameters and cardiovascular disease (CVD) was studied across individuals in the same body mass index (BMI) group. Data from the UK Biobank, a multicountry large population-based study, and the US and Korean National Health and Nutrition Examination Surveys, generating nationally representative samples, were pooled and harmonized. This cross-sectional analysis included 30,520 women and 27,244 men aged 40 years or older.Results
A significant increase in relative risks …Impact Of Iron-Bearing Fillers On The Mechanical Strength And Chemical Stability Of Magnesium Potassium Phosphate Matrices Incorporating Rhenium, Sergey Sayenko, Volodymyr Shkuropatenko, Hans Conrad Zur Loye, Petr Vecernik, Monika Kiselova, Vlastislav Kašpar, Vlastimil Miller, Petr Bezdicka, Jan Šubrt, Petra Ecorchard, Natalija Murafa, Iva Milisavljevic, Scott T. Misture
Impact Of Iron-Bearing Fillers On The Mechanical Strength And Chemical Stability Of Magnesium Potassium Phosphate Matrices Incorporating Rhenium, Sergey Sayenko, Volodymyr Shkuropatenko, Hans Conrad Zur Loye, Petr Vecernik, Monika Kiselova, Vlastislav Kašpar, Vlastimil Miller, Petr Bezdicka, Jan Šubrt, Petra Ecorchard, Natalija Murafa, Iva Milisavljevic, Scott T. Misture
Faculty Publications
We report on the study of the immobilization process of non-radioactive rhenium (Re), a chemical analogue of technetium-99 (99Tc), in compounds based on magnesium potassium phosphate (MKP), as well as the possibility of enhancing their properties with iron-bearing additives/fillers. Powdered Re2O7 was used as the initial Re-containing source. Because of the solubility and high leachability of Tc (VII), which is also volatile at high temperatures, its immobilization for long-term storage and disposal poses a serious challenge to researchers. Taking this into account, low-temperature stabilization technology based on MKP, a cementitious material, is currently considered promising. We prepared experimental …
Rapid Flood Inundation Mapping For Dam Failure And Operations, Shivakumar Balachandran, Parvaneh Nikrou, Ayman Mokhtar Nemnem, Reza Saleh Alipour, Sagy Cohen, Xingong Li, Erfan Goharian, Jasim Imran
Rapid Flood Inundation Mapping For Dam Failure And Operations, Shivakumar Balachandran, Parvaneh Nikrou, Ayman Mokhtar Nemnem, Reza Saleh Alipour, Sagy Cohen, Xingong Li, Erfan Goharian, Jasim Imran
Faculty Publications
Dam failure often causes catastrophic flooding. Although conventional hydrodynamic models are available for generating flood inundation maps, there is a need for low-complexity models that can provide rapid inundation estimates during emergency situations. Operational releases of large volumes may also lead to downstream flooding. This study utilizes two DEM-based models, OWP HAND-FIM and FLDPLN, to produce flood inundation maps for near-real-time operational applications. Three dam-related scenarios, including failures and controlled operations, are examined using these simplified models for the Fall River Dam in Kansas. Breach flows are estimated using empirical relationships, and discharge attenuation is calculated using an analytical approach. …
Ceo Pay Differences Between Us And Non-Us Firms: A New Longitudinal Investigation, Ruiyuan (Ryan) Chen, Sadok El Ghoul, Omrane Guedhami, Feiyu Liu
Ceo Pay Differences Between Us And Non-Us Firms: A New Longitudinal Investigation, Ruiyuan (Ryan) Chen, Sadok El Ghoul, Omrane Guedhami, Feiyu Liu
Faculty Publications
Research Question/Issue
Public and academic debates typically portray US CEOs as exceptionally well paid. Yet, evidence on the existence and magnitude of a US CEO pay premium is mixed and dated. This study uses an expanded, longitudinal dataset to identify whether such a pay premium exists and explores potential differences across countries, time, and governance and institutional contexts.
Research Findings/Insights
Using a dataset of over 42,000 firm-year observations from 34 countries during 2001–2018, we document a persistent but heterogeneous US CEO pay premium. Compared with non-US peers, US CEOs receive 23% more total pay and 20% more equity-based compensation, on …