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Division Of Research And Economic Development Monthly Report For January 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For September 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For February-March 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For October 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For May-June 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For April 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For November 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For December 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For July - October 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Effect Of Hla Dr Epitope De-Immunization Of Factor Viii In Vitro And In Vivo, Leonard Moise, Chang Song, William D. Martin, Ryan Tassone, Anne S. De Groot, David W. Scott

Institute for Immunology and Informatics Faculty Publications

T cell-dependent development of anti-Factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues. Here, we used immunoinformatic tools to identify C2 domain HLA DR epitopes and predict site-specific mutations that reduce immunogenicity. Epitope peptides corresponding to original and modified sequences were validated in HLA binding assays and in immunizations of hemophilic E16 mice, DR3 and DR4 mice and DR3 × E16 mice. Consistent with immunoinformatic predictions, original epitopes …

Teaching Tolerance, Leslie P. Cousens, Federico Mingozzi, Sander Van Der Marel, Yan Su, Richard Garman, Valerie Ferreira, William Martin, David W. Scott, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Babies born with Pompe disease require life-long treatment with enzyme-replacement therapy (ERT). Despite the human origin of the therapy, recombinant human lysosomal acid α glucosidase (GAA, rhGAA), ERT unfortunately leads to the development of high titers of anti-rhGAA antibody, decreased effectiveness of ERT, and a fatal outcome for a significant number of children who have Pompe disease. The severity of disease, anti-drug antibody (ADA) development, and the consequences thereof are directly related to the degree of the enzyme deficiency. Babies born with a complete deficiency GAA are said to have cross-reactive immunologic material (CRIM)–negative Pompe disease and are highly likely …

Development Of An Integrated Economic And Ecological Framework For Ecosystem-Based Fisheries Management In New England, D. Jin, P. Hoagland, Tracey Dalton, E. M. Thunberg

Marine Affairs Faculty Publications

We present an integrated economic-ecological framework designed to help assess the implementation of ecosystem-based fisheries management (EBFM) in New England. We develop the framework by linking a computable general equilibrium (CGE) model of a coastal economy to an end-to-end (E2E) model of a marine food web for Georges Bank. We focus on the New England region using coastal county economic data for a restricted set of industry sectors and marine ecological data for three top level trophic feeding guilds: planktivores, benthivores, and piscivores. We undertake numerical simulations to model the welfare effects of changes in alternative combinations of yields from …

Uri Diversity Awards Banquet Program

Programs and Events (Misc)

Program for the awards banquet in which the URI LBTQ Womens’ Group received their nomination award

Research & Innovation For 2011-2012, University Of Rhode Island

Publications (Research and Economic Development)

The 2011-2012 issue of Research & Innovation, a periodical focused on research at the University of Rhode Island.

Moss Cell Walls: Structure And Biosynthesis, Alison W. Roberts, Eric M. Roberts, Candace H. Haigler

Biological Sciences Faculty Publications

The genome sequence of the moss Physcomitrella patens has stimulated new research examining the cell wall polysaccharides of mosses and the glycosyl transferases that synthesize them as a means to understand fundamental processes of cell wall biosynthesis and plant cell wall evolution. The cell walls of mosses and vascular plants are composed of the same classes of polysaccharides, but with differences in side chain composition and structure. Similarly, the genomes of P. patens and angiosperms encode the same families of cell wall glycosyl transferases, yet, in many cases these families have diversified independently in each lineage. Our understanding of land …

Hypolipidemic Agent Z-Guggulsterone: Metabolism Interplays With Induction Of Carboxylesterase And Bile Salt Export Pump, Dongfang Yang, Jian Yang, Deshi Shi, Da Xiao, Yi-Tzai Chen, Chris Black, Ruitang Deng, Bingfang Yan

Biomedical and Pharmaceutical Sciences Faculty Publications

Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It is generally assumed that the antagonism leads to induction of cytochrome P450 7A1 (CYP7A1), the rate-limiting enzyme converting free cholesterol to bile acids. In this study, we tested whether Z-guggulsterone indeed induces human CYP7A1. In addition, the expression of cholesteryl ester hydrolase CES1 and bile salt export pump (BSEP) was monitored. Contrary to the general assumption, Z-guggulsterone did not induce CYP7A1. Instead, …

Anticancer Activity And Biophysical Reactivity Of Copper Complexes Of 2-(Benzo[D][1,3]Dioxol-5-Ylmethylene)-N-Alkylhydrazinecarbothioamides, Floyd A. Beckford, Jeffrey Thessing, Alyssa Stott, Alvin A. Holder, Oleg G. Poluetov, Liya Li, Navindra P. Seeram

Biomedical and Pharmaceutical Sciences Faculty Publications

A series of copper complexes were synthesized from benzo[d][1,3]dioxole-5-carbaldehyde (piperonal) thiosemicarbazones (RHpTSC where R = H, CH3, C2H5 or C6H5 (Ph)). The complexes show interesting variations in geometry depending on the thiosemicarbazone; a dinuclear complex [Cu(HpTSC)Cl]2, a mononuclear complex [Cu(RHpTSC)2Cl2] (R = CH3 or C2H5) and another mononuclear complex [Cu(PhHpTSC)(PhpTSC)Cl] was generated. The complexes bind in a moderately strong fashion to DNA with binding constants on the order of 10⁴ M^{− 1}. They are also strong binders of human serum albumin with binding constants near 10⁴ M^{− 1}. The complexes show good in vitro …

Distribution Of Cotesia Rubecula (Hymenoptera: Braconidae) And Its Displacement Of Cotesia Glomerata In Eastern North America, M. V. Herlihy, R. G. Van Driesche, M. R. Abney, J. Brodeur, A. B. Bryant, Richard A. Casagrande, D. A. Delaney, T. E. Elkner, S. J. Fleischer, R. L. Groves, D. S. Gruner, J. P. Harmon, G. E. Heimpel, K. Hemady, T. P. Kuhar, C. M. Maund, A. M. Shelton, A. J. Seaman, M. Skinner, R. Weinierl, K. V. Yeargan, Z. Szendrei

Plant Sciences and Entomology Faculty Publications

A survey was conducted from May to Oct of 2011 of the parasitoid community of the imported cabbageworm, Pieris rapae (Lepidoptera: Pieridae), in cole crops in part of the eastern United States and southeastern Canada. The findings of our survey indicate that Cotesia rubecula (Hymenoptera: Braconidae) now occurs as far west as North Dakota and has become the dominant parasitoid of P. rapae in the northeastern and north central United States and adjacent parts of southeastern Canada, where it has displaced the previously common parasitoid Cotesia glomerata (Hymenoptera: Braconidae). Cotesia glomerata remains the dominant parasitoid in the mid-Atlantic states, from …

Metabolic Hypothesis For Human Altriciality, Holly M. Dunsworth, Anna G. Warrener, Terrence Deacon, Peter T. Ellison, Herman Pontzer

Sociology and Anthropology Faculty Publications

The classic anthropological hypothesis known as the “obstetrical dilemma” is a well-known explanation for human altriciality, a condition that has significant implications for human social and behavioral evolution. The hypothesis holds that antagonistic selection for a large neonatal brain and a narrow, bipedal-adapted birth canal poses a problem for childbirth; the hominin “solution” is to truncate gestation, resulting in an altricial neonate. This explanation for human altriciality based on pelvic constraints persists despite data linking human life history to that of other species. Here, we present evidence that challenges the importance of pelvic morphology and mechanics in the evolution of …

Puerto Rican Girls Speak! : The Meanings Of Success For Puerto Rican Girls Ages 14–18 In Hartford, Connecticut, Hilda Lloréns, Carlos G. Garcia-Quijano

Sociology and Anthropology Faculty Publications

This article reports on findings from “Puerto Rican Girls Speak!,” an ethnographic research project carried out during the Spring of 2010 in Hartford, Connecticut, with 18 third-generation Puerto Rican girls ranging in age from 14 to 18 years old. Using mixed ethnographic methods, we examined the ways in which low-income, urban Puerto Rican girls defined success in their lives. For the girls who participated in this study, success is a multidimensional phenomena that includes happiness, wellbeing, life satisfaction, economic independence and stability, and fulfilling social relationships. We explored the role of family, reciprocity, and formal education networks in shaping the …

All Might Have Won, But Not All Have The Prize: Optimal Treatment For Substance Abuse Among Adolescents With Conduct Problems, Jayson Spas, Susan Ramsey, Andrea L. Paiva, L. A.R. Stein

Cancer Prevention Research Center Faculty Publications

Considerable evidence from the literature on treatment outcomes indicates that substance abuse treatment among adolescents with conduct problems varies widely. Treatments commonly used among this population are cognitive-behavioral therapy (CBT), 12-step facilitation, multisystemic therapy (MST), psychoeducation (PE), and motivational interviewing (MI). This manuscript thoroughly and systematically reviews the available literature to determine which treatment is optimal for substance-abusing adolescents with conduct problems. Results suggest that although there are several evidence-based and empirically supported treatments, those that incorporate family-based intervention consistently provide the most positive treatment outcomes. In particular, this review further reveals that although many interventions have gained empirical support …

Unesco, Uri, And Archaeology In The Deep Blue Sea: Archaeological Ethics And Archaeological Oceanography, William H. Krieger, Bridget Buxton

Philosophy Faculty Publications

Multiple groups have interests that intersect within the new field of deep submergence (beyond the 50 meter range of SCUBA) archaeology. These groups‟ differing priorities present challenges for interdisciplinary collaboration, particularly as there are no established guidelines for best practices in such scenarios. Associating the term 'archaeology' with projects directed at underwater cultural heritage that are are not guided by archaeologists poses a real risk to that heritage. Recognizing that the relevant professional organizations, local laws, and conventions currently have little ability to protect pieces of cultural heritage across disciplines and international boundaries, the authors propose institution-specific mechanisms, called Archaeology …

Gender And Women's Studies Newsletter For Spring 2012, Uri Gender And Women's Studies Department

Gender and Women's Studies Publications

The Spring 2012 issue of Gender and Women’s Studies Newsletter, a periodical with articles written by faculty members and some related to events within the Gender and Women’s Studies program.

Using Long-Term Constant-Effort Banding Data To Monitor Population Trends Of Migratory Birds: A 33-Year Assessment Of Adjacent Coastal Stations, Jason E. Osenkowski, Peter W. C. Paton, Douglas Kraus

Natural Resources Science Faculty Publications

One technique for monitoring population trends of many species of migratory songbirds is to assess changes in population indices at constant-effort mist-netting stations located at sites of migration stopover. However, few studies have attempted to validate this approach. We compared long-term (1969–2001) population trends based on annual variation in capture rates at two banding stations located 30 km apart in southern Rhode Island, with one on the mainland, the other on an offshore island. Of 24 species with sufficient sample sizes, 21 species exhibited a significant linear decline at one or both stations. There was a high degree of conformity …

Variation And Trends Of Landscape Dynamics, Land Surface Phenology And Net Primary Production Of The Appalachian Mountains, Yeqiao Wang, Jianjun Zhao, Yuyu Zhou, Hongyan Zhang

Natural Resources Science Faculty Publications

The gradients of elevations and latitudes in the Appalachian Mountains provide a unique regional perspective on landscape variations in the eastern United States and southeastern Canada. We reveal patterns and trends of landscape dynamics, land surface phenology, and ecosystem production along the Appalachian Mountains using time series data from Global Inventory Modeling and Mapping Studies and Advanced Very High Resolution Radiometer Global Production Efficiency Model datasets. We analyze the spatial and temporal patterns of the normalized difference vegetation index (NDVI), length of growing season (LOS), and net primary production (NPP) of selected ecoregions along the Appalachian Mountains regions. We compare …

Surfo Technical Report No. 11-03, Surfo

SURFO Technical Reports

The 2012 technical reports written by undergraduate students participating in the SURFO (Summer Undergraduate Research Fellowships in Oceanography) Program while at the University of Rhode Island.

Adeno-Associated Virus Mediated Delivery Of Tregitope 167 Ameliorates Experimental Colitis, Sander Van Der Marel, Anna Majowicz, Karin Kwikkers, Richard Van Logtenstein, Anje A. Te Velde, Anne S. De Groot, Sybren L. Meijer, Sander J. Van Deventer, Harald Petry, Daniel W. Hommes, Valerie Ferreira

Institute for Immunology and Informatics Faculty Publications

Aim: To explore the anti-inflammatory potential of adeno-associated virus-mediated delivery of Tregitope 167 in an experimental colitis model.

Methods: The trinitrobenzene sulfonate (TNBS) model of induced colitis was used in Balb/c mice. Subsequently after intravenous adeno-associated virus-mediated regulatory T-cell epitopes (Tregitope) delivery, acute colitis was initiated by intra-rectal administration of 1.5 mg TNBS in 40% ethanol followed by a second treatment with TNBS (0.75 mg in 20% ethanol) 8 d later. Control groups included mice not treated with TNBS (healthy control group) and mice treated by TNBS only (diseased group). At the time of sacrifice colon weight, the disease activity …

Introduction To The Special Issue On Job Satisfaction In Fisheries In The Global South, Maarten Bavinck, Richard B. Pollnac, Iris Monnereau, Pierre Failler

Marine Affairs Faculty Publications

No abstract provided.

Cluster Subtypes Appropriate For Preventing Postpartum Smoking Relapse, Mary Colleen Simonelli, Wayne F. Velicer

Cancer Prevention Research Center Faculty Publications

Objective: While the majority of women quit smoking either before or during pregnancy, 60 to 80% relapse in the postpartum period. The objective of this research was to examine postpartum women who quit smoking during their pregnancies and to determine the predictive factors for relapse in the postpartum period by identifying different subgroups that predict risk of relapse.

Method: One hundred forty four postpartum women who were abstinent at the time of delivery were recruited. Data regarding the Acquisition Stage of Change, Decisional Balance and Situational Temptations to Smoke were assessed in the immediate postpartum period. Based on their intention …

P21 Promotes Error-Free Replication-Coupled Dna Double-Strand Break Repair, Maurizio Mauro, Meghan A. Rego, Rebecca A. Boisvert, Fumiko Esashi, Francesca Cavallo, Maria Jasin, Niall G. Howlett

Cell and Molecular Biology Faculty Publications

p21 is a well-established regulator of cell cycle progression. The role of p21 in DNA repair, however, remains poorly characterized. Here, we describe a critical role of p21 in a replication-coupled DNA double-strand break (DSB) repair that is mechanistically distinct from its cell cycle checkpoint function. We demonstrate that p21-deficient cells exhibit elevated chromatid-type aberrations, including gaps and breaks, dicentrics and radial formations, following exposure to several DSB-inducing agents. p21 ^−/− cells also exhibit an increased DNA damage-inducible DNA-PK _CS S2056 phosphorylation, indicative of elevated non-homologous DNA end joining. Concomitantly, p21 ^−/− cells are defective in replication-coupled homologous recombination (HR), …