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Sequencing Our Genomes: From Ancestry To Disease Cmb 260g, Michael Cerbo

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Science And Pseudoscience Cmb 265g, Michael Cerbo

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Curricular Affairs Committee Minutes February 27, 2017, University Of Rhode Island Faculty Senate

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The Five Hundred And Thirty-Eighth Report Of The Curricular Affairs Committee: New Bioinformatics Track In Cell And Molecular Biology., University Of Rhode Island Faculty Senate

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Constitution, By-Laws, And University Manual Committee Report #2016-17-3, Changes To University Manual Chapter 5, Sections 5.70.11, 5.78.10-5.78.12, 5.84.10-5.84.13., University Of Rhode Island Faculty Senate

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Curricular Report No. 2016-17-3 From The Graduate Council To The Faculty Senate: Program Changes., University Of Rhode Island Faculty Senate

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The Five Hundred And Thirty-Eighth Report Of The Curricular Affairs Committee: Program Changes., University Of Rhode Island Faculty Senate

Faculty Senate Bills

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Faculty Senate Meeting Minutes February 23, 2017, University Of Rhode Island Faculty Senate

Faculty Senate Meeting Minutes

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Biology And Society Bio 396, Michael Cerbo

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Information Age: From Politics To Medicine Bio 181g, Michael Cerbo

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Impact Of Consuming ‘Toxic’ Monarch Caterpillars On Adult Chinese Mantid Mass Gain And Fecundity, Jamie Rafter, Liahna Gonda-King, Daniel Niesen, Navindra Seeram, Chad Rigsby, Evan Preisser

Biomedical and Pharmaceutical Sciences Faculty Publications

Predators that feed on chemically-defended prey often experience non-lethal effects that result in learned avoidance of the prey species. Some predators are able to consume toxic prey without ill-effect. The Chinese mantid is able to consume cardenolide-containing monarch caterpillars without immediate adverse effects. Although they discard the caterpillars’ gut contents, mantids consume sequestered cardenolides. Although consumption of these cardenolides does not elicit an acute response, there may be long-term costs associated with cardenolide consumption. We tested the hypothesis that consumption of monarch caterpillars will adversely affect adult mantid biomass gain and reproductive condition. We reared mantids from egg to adult …

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Introduction To Cell And Molecular Biology Cmb 102, Michael Cerbo

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Experimental Approaches In Molecular And Cell Biology Cmb 460, Michael Cerbo

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Arts Trade Association Dinner: Speech Research (1963-1967): Report 04

Arts Trade Association Dinner: Speech Research (1963-1967)

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Curricular Affairs Committee Minutes January 30, 2017, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

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Sustained Epidermal Powder Drug Delivery Via Skin Microchannels, Yan Cao, Prateek Kakar, Md. Nazir Hossen, Mei X. Wu, Xinyuan Chen

Biomedical and Pharmaceutical Sciences Faculty Publications

Transdermal delivery of hydrophilic drugs is challenging. This study presents a novel sustained epidermal powder delivery technology (sEPD) for safe, efficient, and sustained delivery of hydrophilic drugs across the skin. sEPD is based on coating powder drugs into high-aspect-ratio, micro-coating channels (MCCs) followed by topical application of powder drug-coated array patches onto ablative fractional laser-generated skin MCs to deliver drugs into the skin. We found sEPD could efficiently deliver chemical drugs without excipients and biologics drugs in the presence of sugar excipients into the skin with a duration of ~ 12 h. Interestingly the sEPD significantly improved zidovudine bioavailability by …

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The Five Hundred And Thirty-Seventh Report Of The Curricular Affairs Committee., University Of Rhode Island Faculty Senate

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Differential Feedback Regulation Of Δ4-3- Oxosteroid 5Β-Reductase Expression By Bile Acids, Leila Valanejad, Christina Nadolny, Stephanie Shiffka, Yuan Chen, Sangmin You, Ruitang Deng

Biomedical and Pharmaceutical Sciences Faculty Publications

Δ⁴-3-oxosteroid 5β-reductase is member D1 of the aldo-keto reductase family 1 (AKR1D1), which catalyzes 5β-reduction of molecules with a 3-oxo-4-ene structure. Bile acid intermediates and most of the steroid hormones carry the 3-oxo-4-ene structure. Therefore, AKR1D1 plays critical roles in both bile acid synthesis and steroid hormone metabolism. Currently our understanding on transcriptional regulation of AKR1D1 under physiological and pathological conditions is very limited. In this study, we investigated the regulatory effects of primary bile acids, chenodeoxycholic acid (CDCA) and cholic acid (CA), on AKR1D1 expression. The expression levels of AKR1D1 mRNA and protein in vitro and in …

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In Vivo Detection Of Cucurbit[6]Uril, A Hyperpolarized Xenon Contrast Agent For A Xenon Magnetic Resonance Imaging Biosensor, Francis T. Hane, Tao Li, Peter Smylie, Raiili M. Pellizzari, Jennifer A. Plata, Brenton Deboef, Mitchell S. Albert

Chemistry Faculty Publications

The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivodetection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality.

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Origins: Life, The Universe And Everything Hpr 201, Michael Cerbo

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Oceanographic Data In Rhode Island Waters Ocg 150, Joanna Burkhardt

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Humanities: State Agencies (September 15, 1975): Report 06

Humanities: State Agencies (September 15, 1975)

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Design, Synthesis, And Evaluation Of Dasatinib–Amino Acid And Dasatinib–Fatty Acid Conjugates As Protein Tyrosine Kinase Inhibitors, Rakesh K. Tiwari, Alex Brown, Neda Sadeghiani, Amir Nasrolahi Shirazi, Jared Bolton, Amanda Tse, Gennady Verkhivker, Keykavous Parang, Gongqin Sun

Cell and Molecular Biology Faculty Publications

Derivatives of the tyrosine kinase inhibitor dasatinib were synthesized by esterification with 25 carboxylic acids, including amino acids and fatty acids, thereby extending the drug to interact with more diverse sites and to improve specificity. The dasatinib–l-arginine derivative (Das-R, 7) was found to be the most potent of the inhibitors tested, with IC50values of 4.4, <0.25, and <0.45 nm against Csk, Src, and Abl kinases, respectively. The highest selectivity ratio obtained in our study, 91.4 Csk/Src, belonged to compound 18 (Das-C10) with an IC50value of 3.2 μm for Csk compared with 35 nm for Src. Furthermore, many compounds displayed increased selectivity toward Src over Abl. Compounds 15 (Das–glutamic acid) and 13 (Das–cysteine) demonstrated the largest gains (10.2 and 10.3 Abl/Src IC50ratios). Das-R (IC50=2.06 μm) was significantly more potent than the parent dasatinib (IC50=26.3 μm) against Panc-1 cells, whereas both compounds showed IC50<51.2 pm against BV-173 and K562 cells. Molecular modeling and binding free energy simulations revealed good agreements with the experimental results and rationalized the differences in selectivity among the studied compounds. Integration of experimental and computational approaches in the design and biochemical screening of dasatinib derivatives facilitated rational engineering and diversification of the dasatinib scaffold, providing useful insight into mechanisms of kinase selectivity.

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Trichophycin A, A Cytotoxic Linear Polyketide Isolated From A Trichodesmium Thiebautii Bloom, Matthew Bertin, Paul G. Wahome, Paul V. Zimba, Haiyin He, Peter D. R. Moeller

Biomedical and Pharmaceutical Sciences Faculty Publications

In an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided extraction and fractionation using the human colon cancer cell line HCT-116, resulting in the isolation and subsequent structure characterization of a linear polyketide trichophycin A (1). The planar structure of 1 was completed using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS). Trichophycin A was moderately toxic against the murine neuroblastoma cell line Neuro-2A (EC₅₀: 6.5 μM) and HCT-116 cells (EC₅₀: 11.7 μM). Trichophycin A was significantly more cytotoxic than the …

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Surfo Technical Report No. 17-01, Surfo

SURFO Technical Reports

The 2017 technical reports written by undergraduate students participating in the SURFO (Summer Undergraduate Research Fellowships in Oceanography) Program while at the University of Rhode Island for ten weeks.

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