Digital Commons Network^™

Fundamentals Of Human Anatomy And Physiology Ii Bio 222, Michael Cerbo

Library Impact Statements

No abstract provided.

Measuring Media Literacy For Media Education: Development Of A Questionnaire For Teachers' Competencies, Mathea Simons, Wil Meeus, Jan T'Sas

Journal of Media Literacy Education

Effective media education requires that teachers dispose of sufficient media literacy and that they have the competencies to promote media literacy in students. This article describes the development of a questionnaire to measure these competencies individually or as a team. The questionnaire was developed in five stages. A systematic and critical listing of existing inventories resulted in a preliminary questionnaire. In the final stage, the questionnaire was submitted to a representative sample of 454 teachers and 219 student teachers, and an exploratory factor analysis was conducted. The results show that the questionnaire is sufficiently valid and reliable.

Walking The Line Between Reality And Fiction In Online Spaces: Understanding The Effects Of Narrative Transportation, Sarah Gretter, Aman Yadav, Benjamin Gleason

Journal of Media Literacy Education

Recent contentions about "fake news" and misinformation online has shed light on the critical need for media literacy at a global scale. Indeed, digital stories are one of the main forms of communication in the 21st century through blogs, videos-sharing websites, forums, or social networks. However, the line between facts and fiction can often become blurry in these online spaces, and being able to distinguish between reality and fantasy can have important consequences in the lives of young Internet users. Using contemporary examples from news stories, fanfiction, advertising, and radicalization, this article outlines the features, affordances, and real-life implications of …

Tricholides A And B And Unnarmicin D: New Hybrid Pks-Nrps Macrocycles Isolated From An Environmental Collection Of Trichodesmium Thiebautii, Matthew Bertin, Alexandre Roduit, Jiadong Sun, Gabriella Alves, Christopher Via, Miguel Gonzalez, Paul V. Zimba, Peter D. R. Moeller

Biomedical and Pharmaceutical Sciences Faculty Publications

Bioassay-guided isolation of the lipophilic extract of Trichodesmium thiebautii bloom material led to the purification and structure characterization of two new hybrid polyketide-non-ribosomal peptide (PKS-NRPS) macrocyclic compounds, tricholides A and B (1 and 2). A third macrocyclic compound, unnarmicin D (3), was identified as a new depsipeptide in the unnarmicin family, given its structural similarity to the existing compounds in this group. The planar structures of 1–3 were determined using 1D and 2D NMR spectra and complementary spectroscopic and spectrometric procedures. The absolute configurations of the amino acid components of 1–3 were determined via acid hydrolysis, derivitization with Marfey’s reagent …

Development And Physicochemical Characterization Of Acetalated Dextran Aerosol Particle Systems For Deep Lung Delivery, Zimeng Wang, Sweta K. Gupta, Samantha A. Meenach

Chemical, Biomolecular, and Materials Engineering Faculty Publications

Biocompatible, biodegradable polymers are commonly used as excipients to improve the drug delivery properties of aerosol formulations, in which acetalated dextran (Ac-Dex) exhibits promising potential as a polymer in various therapeutic applications. Despite this promise, there is no comprehensive study on the use of Ac-Dex as an excipient for dry powder aerosol formulations. In this study, we developed and characterized pulmonary drug delivery aerosol microparticle systems based on spray-dried Ac-Dex with capabilities of (1) delivering therapeutics to the deep lung, (2) targeting the particles to a desired location within the lungs, and (3) releasing the therapeutics in a controlled fashion. …

High‐Frequency Dissolved Organic Carbon And Nitrate Measurements Reveal Differences In Storm Hysteresis And Loading In Relation To Land Cover And Seasonality, M. C. H. Vaughan, W. B. Bowden, J. B. Shanley, A. Vermilyea, R. Sleeper, Arthur J. Gold, Soni M. Pradhanang, S. P. Inamdar, D. F. Levia, A. S. Andres, F. Birgand, A. W. Schroth

Natural Resources Science Faculty Publications

Storm events dominate riverine loads of dissolved organic carbon (DOC) and nitrate and are expected to increase in frequency and intensity in many regions due to climate change. We deployed three high‐frequency (15 min) in situ absorbance spectrophotometers to monitor DOC and nitrate concentration for 126 storms in three watersheds with agricultural, urban, and forested land use/land cover. We examined intrastorm hysteresis and the influences of seasonality, storm size, and dominant land use/land cover on storm DOC and nitrate loads. DOC hysteresis was generally anticlockwise at all sites, indicating distal and plentiful sources for all three streams despite varied DOC …

Preliminary Study Examining The Presence Of A Wolbachia Endosymbiont In Winter Moth Populations, Matthew Pederson

Senior Honors Projects

Operophtera brumata, also known as the winter moth, is a Geometrid native to Eastern Europe. It was introduced to North America in the early 1900’s, and over the last decade has become an invasive species in New England. The moth’s larvae defoliate a variety of hardwood and fruit bearing plants, resulting in high stress on leaf regeneration and eventual death for the trees. This can be an economic problem for farmers who grow apples and blueberries. This study aimed to better understand the moth’s invasion regarding its endosymbiosis with the bacterium, Wolbachia pipientis. Wolbachia is a common endosymbiont …

[Not] Buying It: Prostitution As Unwanted Sex, Rebecca Whisnant

Dignity: A Journal of Analysis of Exploitation and Violence

Noting the relative invisibility of prostitution buyers, or Johns, in discussions of the morality of prostitution, this article criticizes Johns’ behavior on the grounds that they are culpably involved in causing the typical harms of prostitution in the lives of the women whom they pay for sex. Those harms are, at bottom, the result of being habitually subjected to unwanted sex, and they are exacerbated rather than mitigated by such sex being bought and paid for. Efforts to normalize and legalize sex-buying should therefore be resisted.

Divergent Evolutionary Histories Of Dna Markers In A Hawaiian Population Of The Coral Montipora Capitata, Hollie M. Putnam, Diane K. Adams, Ehud Zelzion, Nicole E. Wagner, Huan Qiu, Tali Mass, Paul G. Falkowski, Ruth D. Gates, Debashish Bhattacharya

Biological Sciences Faculty Publications

We investigated intra- and inter-colony sequence variation in a population of the dom- inant Hawaiian coral Montipora capitata by analyzing marker gene and genomic data. Ribosomal ITS1 regions showed evidence of a reticulate history among the colonies, suggesting incomplete rDNA repeat homogenization. Analysis of the mitochondrial genome identified a major (M. capitata) and a minor (M. flabellata) haplotype in single polyp-derived sperm bundle DNA with some colonies containing 2-3 different mtDNA haplotypes. In contrast, Pax-C and newly identified single-copy nuclear genes showed either no sequence differences or minor variations in SNP frequencies segregating among the colonies. …

08. Amphiphiles I, Gerhard Müller

Soft Matter Physics

Part eight of course materials for Soft Matter Physics (Physics 625), taught by Gerhard Müller at the University of Rhode Island. Documents will be updated periodically as more entries become presentable.

01. Fundamentals I, Gerhard Müller

Soft Matter Physics

Part one of course materials for Soft Matter Physics (Physics 625), taught by Gerhard Müller at the University of Rhode Island. Documents will be updated periodically as more entries become presentable.

04. Polymers I, Gerhard Müller

Soft Matter Physics

Part four of course materials for Soft Matter Physics (Physics 625), taught by Gerhard Müller at the University of Rhode Island. Documents will be updated periodically as more entries become presentable.

The Fifth Epoch: Socio-Economic Approach To Sustainable Capitalism, David M. Boje, Yue Cai Hillon

Markets, Globalization & Development Review

The purpose of this conceptual essay is to challenge the inevitability of living with the destructive beast of speculative market economics in the 4^th epoch of global capitalism. We are facing an existential socio-ecological threat from the short-term excesses of financial capitalism, a socially irresponsible form that consumes without producing value and without bearing entrepreneurial risk, benefitting only the few. The fate of roughly 90% of humanity hangs in the balance. The primary contribution of this paper proposes a 5^th epoch of capitalism, inspired by Savall and Zardet’s socio-economic and sustainable approach that restores human potential and value …

The Protein Chaperone Clpx Targets Native And Non-Native Aggregated Substrates For Remodeling, Disassembly, And Degradation With Clpp, Christopher J. Labreck, Shannon May, Marissa G. Viola, Joseph Conti, Jodi L. Camberg

Cell and Molecular Biology Faculty Publications

ClpX is a member of the Clp/Hsp100 family of ATP-dependent chaperones and partners with ClpP, a compartmentalized protease, to degrade protein substrates bearing specific recognition signals. ClpX targets specific proteins for degradation directly or with substrate-specific adaptor proteins. Native substrates of ClpXP include proteins that form large oligomeric assemblies, such as MuA, FtsZ, and Dps in Escherichia coli. To remodel large oligomeric substrates, ClpX utilizes multivalent targeting strategies and discriminates between assembled and unassembled substrate conformations. Although ClpX and ClpP are known to associate with protein aggregates in E. coli, a potential role for ClpXP in disaggregation remains poorly characterized. …

Faculty Senate Meeting Minutes May 4, 2017, University Of Rhode Island Faculty Senate

Faculty Senate Meeting Minutes

No abstract provided.

Low-Dose 5-Fluorouracil Sensitizes Hepg2 Cells To Trail Through Trail Receptor Dr5 And Survivin-Dependent Mechanisms, Lijun Yang, Yutao Wang, Haifeng Zheng, Dong Zhang, Xiangwei Wu, Gongqin Sun, Tao Yang

Cell and Molecular Biology Faculty Publications

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer treatment due to its highly selective apoptosis-inducing action on tumour cells without harming normal cells. However, because of TRAIL resistance by some cancer cells, combined treatment with sensitizing agents is required to enhance the anticancer potential of TRAIL. In the present study, we investigated the sensitizing effect of 5-fluorouracil (5-FU) on TRAIL-induced apoptosis in TRAIL-resistant HepG2 hepatocarcinoma cells. The results show that 5-FU pretreatment could sensitize HepG2 cells to TRAIL-mediated apoptosis. The enhanced induction of cell death by the 5-FU/TRAIL combination was mediated by DR5 up-regulation and survivin …

The Golden Girls: Addressing Issues Of Gender, Stigma, And Illness On Network Television, Miles Martin

Senior Honors Projects

Over thirty years after its 1985 premiere, The Golden Girls remains an alluring and nostalgic presence in the cultural consciousness of America. In this work, I investigate exactly what it is about this magical show that has caused it to endure across generations, and in so doing, illuminate how television in general can transcend incidental popularity and have a lasting impact on those who view it. I frame this examination within the topic of disenfranchised illness, a subject that, given events such as the rise of HIV/AIDS, the emergence of crack-cocaine addiction, and the discovery of chronic fatigue syndrome in …

Investigating The Genetic Basis For Hominoid Taillessness, Samantha M. Tickey-Mccrane, Holly Dunsworth, Johanna E. Wegener

Senior Honors Projects

Investigating the Genetic Basis for Hominoid Taillessness:

A Comparative Genetic Approach Across Ten Catarrhine Taxa

Samantha Tickey-McCrane1,2, Johanna E. Wegener2, and Holly Dunsworth1

Honors Thesis Abstract Written by Samantha Tickey-McCrane, Departments of Anthropology & Biology

Advisor: Dr. Holly Dunsworth, Department of Anthropology

How did hominoid tail loss occur? My goals are to test phylogenetic and adaptive hypotheses for tail length variation among macaques, and use those insights to reconstruct the evolution of hominoid taillessness. Further, I aim to ultimately uncover which candidate genes or pathways may be responsible for catarrhine tail loss, and what other traits may be affected by …

Mechanism Of Lck Activation In Driving Leukemia Cell Proliferation, Hannah E. Dobson

Senior Honors Projects

Leukemia is a type of cancer that develops in blood-forming tissues of the immune system. These tissues can include the bone marrow or sites within the lymphatic system such as the lymph nodes. Leukemia progresses from a mutational event within a white blood cell. Often this mutation alters the cell’s normal life cycle, resulting in uninhibited cell division and growth. With this uncontrolled cell proliferation, mutated white blood cells accumulate and begin interfering with the functioning of healthy cells.

Scientists are unsure of the exact mechanisms required for leukemia development. However, recently scientists identified four characteristic mutations in the protein …

The Hard Science Of Soft Skills, Marisa J. Decollibus

Senior Honors Projects

In the American education system, students’ abilities in subjects like math and social studies are calculated using quantitative metrics. When it comes to their social and emotional skills, these same systems of evaluation may not be transferable. As schools begin to invest resources in social and emotional learning (SEL) and mindfulness programs, it becomes even more important to investigate and understand rigorous methods of evaluation. These methods must be able to offer an accurate picture of a student’s diverse set of social and emotional skills including competencies in self/social awareness, good decision making, and community engagement, to name a few. …

Kinetic Studies Of Dna Repair Enzyme Alkbh2, Michael R. Vittori

Senior Honors Projects

The genomes of living organisms are under constant bombardment from various sources, including chemical modification stemming from processes within the organisms themselves or from exogenous agents, and from radiation. These sources of genomic damage may induce structural changes in the genome’s most basic functional units, the nucleotides that comprise DNA. Damage to an organism’s DNA may result in the production of dysfunctional or nonfunctional proteins. Failure to repair such damage may result in the compounding of successive mutations within the organism’s genome, the pathogenesis of cancer and various genetic disorders in humans. To ensure their viability, organisms have developed unique …

Do Halogenated Natural Products Bioaccumulate In Narragansett Bay?, Christine Gardiner, Anna Robuck, Rainer Lohmann

Senior Honors Projects

In recent decades, a new family of chemical compounds has begun to garner research attention—halogenated natural products, or HNPs. These chemicals are produced by algae, bacteria, worms, and sponges, and many are structurally similar to harmful manmade compounds, such as polychlorinated diphenyls (PCBs), or brominated flame retardants (PBDEs), which are known to cause cancer, reproduction issues, endocrine disruption, and death. While HNPs are produced naturally, they are still considered pollutants because of their bioaccumulative behavior and apparent toxicity.

Currently, there is limited research on their presence and effects, with a few studies from Europe and the Pacific highlighting their importance …

A Behavioral Prerequisite For The Genetic Analysis Of Auditory Feature Detection Mechanisms In Female Crickets, Rebecca L. Blisko

Senior Honors Projects

Sexual dimorphism is exhibited across all cricket species and is a central aspect of the mating processes of these insects. Only male crickets possess wing structures and pattern generators in the central nervous system that allow them to produce a mating call that is unique to their species in order to attract conspecific females. Conspecific females possess an auditory feature detection circuit in the central nervous system that is capable of detecting the species-specific frequency and temporal pattern of sound pulses within a male call. In order for dimorphic differences in mating behavior to result in successful continuation of a …

Sometimes Laughter Is The Best Medicine: Stand-Up Comedy, Humor, And Healthcare, Haran Mennillo

Senior Honors Projects

While for many healthcare is no laughing matter, humor can be a valuable tool for physicians. Hospitals and other healthcare environments can be very stressful places for patients, many of whom are having the worst day of their lives. Humor is an excellent medium through which doctors can connect with their patients, improving the doctor-patient relationship. Patients will often use humor as a way to cope with their stress, and doctors with a sense of humor are able to better connect with their patients. This use of humor has many applications across different fields of medicine, including pediatrics, oncology, palliative …

Global At Uri: International Exchange Students Within Uri’S 21st Century Learning Environment, Wilfredo J. Tangui

Senior Honors Projects

Universities around the world have been transforming their students into global citizens in part by establishing international university partnerships to help provide opportunities to develop cross-cultural competencies. Outlined within the 2016-2021 Academic Strategic Plan, one of the central goals of the University of Rhode Island (URI) is enabling a 21st century 24/7 learning environment to work across various cultures in what has been defined as an ever-increasingly interconnected world. This paper intends to highlight the existing methodologies in place for the inclusion of bilateral exchange international students in the undergraduate community of the University of Rhode Island. I aim to …

Ultrasonically Responsive Tissue Engineering Scaffolds For The Temporal Control Over Osteo-Inductive Growth Factor Delivery, Catherine Linh

Senior Honors Projects

In 2012, approximately 6.8 million people in the United States were diagnosed with orthopedic injuries or diseases. Over 500,000 people in the United States underwent bone grafting procedures, which cost 2.5 billion dollars per year and can result in complications. Polymer-based grafting scaffolds can facilitate 3D bone tissue growth in a localized, sustained manner. However, bone regeneration requires the orchestration of a sequence of events. Current scaffolds based on degradation and diffusion cannot provide sequential deliveries. We aimed to design a polymer scaffold that can release one payload diffusively at early time points, followed by ultrasonically triggered release of a …

Do Non-Human Primates Have Gender?, Aaron Pelchat

Senior Honors Projects

As activism for trans rights and gender equality becomes ever more prevalent in the current American political discourse, so too has there been a rise in questions about gender. Are sexuality and gender linked? Aren’t there only two genders? What is the difference between gender and sex? Is there a difference? How does one DO gender? Isn’t gender just something you are born with? Helping the public understand these questions is important to transgender and gender non-conforming individuals in a time when more people are “coming out of the closet” and identifying as genders other than cisgender. As an anthropologist, …

Opioid Use In Rhode Island - Review And Suggestions, Vanessa S. Kolb

Senior Honors Projects

It is estimated that over two million Americans have an opioid-related substance abuse disorder. Nationally, 91 people die every day from an opioid overdose, and 60% of drug overdoses involve an opioid. Rhode Island has enacted some of the strictest opioid-prescribing guidelines in the country, but since 2011 the number of overdose deaths within the state that involve illicit opioids has increased by 250%. In 2015, Governor Gina Raimondo established a special task force whose goal is to reduce the number of opioid-related overdose deaths in Rhode Island by one-third by 2018.

In this project, I analyze and compare best …

Creative Nonnatives: Painting Invasive Insects Of The United States, Monica Tynan

Senior Honors Projects

An invasive species is a nonnative organism that may cause damage to an ecosystem. Invasive species cause problems in an environment by outcompeting native organisms for resources or by feeding upon native species. Invasive insects in particular can harm an ecosystem by consuming foliage and decreasing biodiversity. During my experience at the Preisser Lab at the University of Rhode Island, I witnessed rsthand the damage that invasive insects can do to a tree population, and I learned about how ecosystem dynamics can be disrupted by the introduction of a nonnative species.

My project portrays an aesthetically pleasing visualization of several …

Soul Simplicity: An Inquiry Into Dance, Women And Islam, Mariam T. Odetunde

Senior Honors Projects

Islam has guidelines and rules that its followers must abide by in order to fulfill the tenets of the religion. Lawful acts are labeled “al-halal” and the unlawful and prohibited are “al-haram.” Many al-haram activities affect Muslim women specifically – particularly some leisure activities, such as listening to music and dancing. For example, Islam does not permit activities that can be perceived as “erotic” or “arousing male passions.” Elder Muslim women guide and supervise younger women in order to pass along religious morals and values from generation to generation. I am the product of this tradition and my research is …