Digital Commons Network^™

Mechanistic Studies To Elucidate The Role Of Lipid Vehicles On Solubility, Formulation And Bioa Vailability Of Poorly Soluble Compounds, Inayet Dumanli

Open Access Dissertations

Lipids have been utilized to increase the bioavailability of poorly soluble drugs which resulted in with advent of High Throughput Screening (HTS). Although lipids have been used to improve bioavailability of a few drugs for almost twenty years, they are still not well characterized. There are limited publications about the effects of physicochemical properties of the lipid vehicle, such as class of lipid (i.e. glyceride, propylene glycol ester), fatty acid chain length, MW and polarity on lipid solubility, formulation and bioavailability of poorly soluble drugs. Knowledge of such relationship can improve quick screening of these vehicles. The goals of this …

Function Of The Heterocercal Tail In Sharks: Quantitative Wake Dynamics During Steady Horizontal Swimming And Vertical Maneuvering, C. D. Wilga, G. V. Lauder

Biological Sciences Faculty Publications

The function of the heterocercal tail in sharks has long been debated in the literature. Previous kinematic data have supported the classical theory which proposes that the beating of the heterocercal caudal fin during steady horizontal locomotion pushes posteroventrally on the water, generating a reactive force directed anterodorsally and causing rotation around the center of mass. An alternative model suggests that the heterocercal shark tail functions to direct reaction forces through the center of mass. In this paper, we quantify the function of the tail in two species of shark and compare shark tail function with previous hydrodynamic data on …

New England Salt Marsh Pools: Analysis Of Geomorphic And Geographic Parameters, Macrophyte Distribution And Nekton Use, Susan C. Adamowicz

Open Access Dissertations

Salt marsh pools are shallow, steep-sided depressions that remain flooded throughout a tidal cycle and provide important habitat for nekton (fish and decapod crustaceans). Although New England pools are relatively unstudied, efforts are underway to expand pool habitat through an open marsh water management technique know as ditch plugging. The purpose of this study was to quantify pool geomorphic and geographic characteristics, to determine distribution of vegetative cover types and nekton species, and to evaluate effects of ditch plugging on nekton use of pools.

Over 30 ditched and unditched marshes were surveyed from the Connecticut shore of Long Island Sound …

Regulation And Mechanisms Of Excitation-Contraction Coupling In The Ventricular Myocardium Of The Surf Clam, Spisula Solidissima, Leon Paul Collis

Open Access Dissertations

Extensive research has previously examined the extrinsic, neural regulation of the bivalve myocardium, via the action of such neurotransmitters as acetylcholine, serotonin and the tetrapeptide, FRMFamide. This investigation was performed in order to identify any intrinsic, autoregulatory (mechanical or pharmacological) processes, which attenuate or amplifier cardiac activity. For this purpose, the ventricular muscle of the bivalve, Spisula solidissima , was used. The ultrastructure was described in order to explain specific excitation-contraction (EC) coupling mechanisms that were elucidated in this study. Manuscript 1 identified and characterized shortening deactivation in ventricular trabeculae of the surf clam. This is defined as the loss …

Effects Of Mobile Fishing Gear On The Benthic Megafauna And Production Of Georges Bank, Jerome Michael Hermsen Jr.

Open Access Dissertations

Although the effects of mobile fishing gear on the habitat and productivity of the sea bottom has warranted attention for several centuries, recent concern has fueled an upsurge in research into the ecosystem effects of fishing over the last decade. This dissertation addresses the effects of mobile fishing gear disturbance on the benthic megafaunal productivity, scavenging amphipods and isopods, and benthic habitat-mediated survival of juvenile cod ( Gadus morhua). Using baited traps, scavenging amphipod and isopod populations were sampled at deep and shallow sites in disturbed and undisturbed areas on the northern part of Georges Bank and in the Great …

Geomagnetic Sensitivity And Orientation In Eastern Garter Snakes (Thamnophis Sirtalis), Douglas Eliot Smith

Open Access Dissertations

Thirteen eastern garter snakes (Thamnophis sirtalis) were each kept in a terrarium for 10 to 15 days inside a solenoid made of electrical wire and attached to a DC power source. When activated, the solenoid reduced the intensity and reversed the direction of the ambient magnetic field inside the aquarium. Food was placed in an L-shaped corridor attached to the aquarium before the solenoid was turned on. The time between activation of the solenoid and the first strike at the food was measured. Snakes that were exposed to the magnetic cue learned to associate it with the presence of food …

Curricular Report No. 2001-2002-3 From The Graduate Council To The Faculty Senate, University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

The Four Hundredth Report Of The Curricular Affairs Committee, University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

The Good 5 Cent Cigar (12/06/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

Hepp News, Vol. 4 No. 12, Hiv & Hepatitis Education Prison Project

Infectious Diseases in Corrections Report (IDCR)

No abstract provided.

The Good 5 Cent Cigar (11/29/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (11/28/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

Curricular Affairs Committee Report #400, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

Graduate Council Report No. 2001-2002-3, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

The Good 5 Cent Cigar (11/14/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (11/09/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

Hepp News, Vol. 4 No. 11, Hiv & Hepatitis Education Prison Project

Infectious Diseases in Corrections Report (IDCR)

No abstract provided.

The Good 5 Cent Cigar (10/30/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (10/26/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

Curricular Report No. 2001-2002-1 From The Graduate Council To The Faculty Senate, University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

The Three Hundred And Ninety-Ninth Report Of The Curricular Affairs Committee, University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

The Good 5 Cent Cigar (10/18/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (10/16/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (10/11/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (10/10/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (10/05/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

Curricular Affairs Committee Report #399, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

Hepp News, Vol. 4 No. 10, Hiv & Hepatitis Education Prison Project

Infectious Diseases in Corrections Report (IDCR)

No abstract provided.

The Good 5 Cent Cigar (09/28/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (09/25/2001), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.