Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Plymouth

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 781 - 810 of 11796

Full-Text Articles in Entire DC Network

Management Responses To Staff Speaking Up In The Nhs: A Scoping Review, Melika Ghorbankhani, Aled Jones, Alison James, Ben Hannigan, Dominic Roche Aug 2025

Management Responses To Staff Speaking Up In The Nhs: A Scoping Review, Melika Ghorbankhani, Aled Jones, Alison James, Ben Hannigan, Dominic Roche

School of Nursing and Midwifery

Staff speaking up about patient safety concerns is crucial to improving care and learning from mistakes. Poor management responses to speaking up can result in missed opportunities to prevent harm and hinder staff learning. This scoping review explored the literature on managers' responses to staff-raised patient safety concerns in the NHS, identifying key factors that influence these responses and suggesting strategies for improvement. Arksey and O'Malley's five-stage framework was used to systematically analyse studies from databases such as MEDLINE, PubMed, EMBASE, APA PsycINFO and CINAHL. The review included 25 studies published between 2005 and 2023. Eleven identified studies were based …


Counteracting Cascades Challenge The Heterogeneity-Stability Relationship, Jordi Sola, Tom P. Fairchild, Matthew J. Perkins, James C. Bull, John N. Griffin Aug 2025

Counteracting Cascades Challenge The Heterogeneity-Stability Relationship, Jordi Sola, Tom P. Fairchild, Matthew J. Perkins, James C. Bull, John N. Griffin

School of Biological and Marine Sciences

Spatial environmental heterogeneity is widely assumed to enhance ecological stability by promoting refugia, biodiversity and asynchrony. Yet, we lack field experiments testing this fundamental relationship and its underlying mechanisms in naturally assembled multitrophic systems. To address this gap, we monitored experimental substrates replicating topographic heterogeneity on a rocky shore over 3 years. Contrary to theory, heterogeneity showed no net effect on community stability due to four counteracting pathways. Heterogeneity increased stability by (i) providing refugia that enhanced population stability and (ii) boosting species richness, which promoted asynchrony. At the same time, it decreased stability by (iii) reducing a dominant non-native …


Sensing Freedom: Forensic Mental Health Ot & Service User Perspectives Of Sensory Processing & Occupational Participation, Elana Moore, Rosi Raine, Alison Warren, Karen Beaulieu Aug 2025

Sensing Freedom: Forensic Mental Health Ot & Service User Perspectives Of Sensory Processing & Occupational Participation, Elana Moore, Rosi Raine, Alison Warren, Karen Beaulieu

School of Health Professions

ABSTRACT SYNOPSIS:UK research explored forensic mental health occupational therapist and service user experiences of sensory processing and occupational participation. The incorporation of sensory processing information in occupation-focused practice is recommended.LEARNING OBJECTIVES:At the conclusion of this session, participants will be able to appreciate the utility of an experiential approach in occupational therapy research.At the conclusion of this session, participants will be able to consider how to incorporate sensory processing in occupation-focused practice.At the conclusion of this session, participants will be able understand the importance of addressing Transactionalism in occupational therapy.ABSTRACT:Purpose:The phenomenon of sensory processing is an everyday experience which occurs in …


Impact Of Patient Diaries On Children, Families, And Healthcare Professionals In Paediatric Intensive Care Settings: A Scoping Review, Fiona Lynch, Jos M Latour, Ruth Endacott Aug 2025

Impact Of Patient Diaries On Children, Families, And Healthcare Professionals In Paediatric Intensive Care Settings: A Scoping Review, Fiona Lynch, Jos M Latour, Ruth Endacott

School of Nursing and Midwifery

OBJECTIVE: The aim of this scoping review was to understand the current landscape, features, and volume of evidence that address the review question: what is the impact of Paediatric Intensive Care Unit (PICU) patient diaries on children, families, and healthcare professionals (HCPs)? To provide context: descriptions of diary models was also provided.

METHOD: The search strategy was structured using the Population, Concept, and Context model to focus the review question. The inclusion criteria were intentionally broad to include all studies published in English from January 2016 until November 2024. The databases CINAHL, Medline, and EMBASE were used to retrieve articles, …


Microplastics And Other Plastic-Like Microdebris In Sediments From The Dart River And Estuary, Southwest England, Maia Killian, Andrew Turner Aug 2025

Microplastics And Other Plastic-Like Microdebris In Sediments From The Dart River And Estuary, Southwest England, Maia Killian, Andrew Turner

School of Geography, Earth and Environmental Sciences

Surficial sediment samples (n = 10) collected from a transect of a river-estuary (Dart) in southwest England have been analysed for geochemical characteristics, anthropogenic metals (Cr, Cu, Sn, Pb, Zn), and microplastics (∼50 μm–5 mm) and other microplastic-like debris. Results indicated the finest grains towards the lower river and upper estuary, a seaward increase in sedimentary Ca, and loss on ignition ranging from about 0.7 to 4 %. Anthropogenic metals were heterogeneously distributed throughout the catchment with maximum concentrations in the river or lower estuary. Microplastics were dominated by fibres, with concentrations ranging from 110 to 1800 kg−1 and composition …


Implementation Of Link Workers In Primary Care: Synopsis Of Findings From A Realist Evaluation, Stephanie Tierney, Geoff Wong, Debra Westlake, Amadea Turk, Steven Markham, Jordan Gorenberg, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Tony Meacock, Catherine Pope, Beccy Baird, Kamal R. Mahtani Aug 2025

Implementation Of Link Workers In Primary Care: Synopsis Of Findings From A Realist Evaluation, Stephanie Tierney, Geoff Wong, Debra Westlake, Amadea Turk, Steven Markham, Jordan Gorenberg, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Tony Meacock, Catherine Pope, Beccy Baird, Kamal R. Mahtani

Peninsula Medical School

Background: Social prescribing link workers formed part of the Additional Roles Reimbursement Scheme introduced into primary care in England from 2019. Link workers assist patients experiencing issues affecting their health and well-being that are 'non-medical' (e.g. lack of social connections, financial difficulties and housing problems). They give patients space to consider these non-medical issues and, when relevant, connect them to support, often within the voluntary-community-social-enterprise sector. We conducted an earlier realist review on the link worker role in primary care. We then carried out a realist evaluation, described in this report, to address the question: When implementing link workers in …


Training To Teach: Creating Inclusive Learning Environments, Rebecca Anne Rose Jul 2025

Training To Teach: Creating Inclusive Learning Environments, Rebecca Anne Rose

Plymouth Interdisciplinary Education Open Journal

Inclusion is often discussed as a policy imperative, but its true impact is realised only through daily classroom practice. As student teachers, we argue that inclusion should move beyond compliance to become a mindset and a lived commitment. Our experiences reveal that policy and practice are not always as intertwined as we hope. As future educators, we aspire for inclusion to require ongoing self-reflection, courage, and compassion, ensuring every student is seen, valued, and empowered to succeed. We believe policy must genuinely support and reflect this commitment, making inclusion not just a requirement, but a fundamental part of educational culture …


Reflection On The ‘Power Of Us’ Conference: How Mainstream Schools In England Offer Provision To Children With Special Educational Needs (Sen), Grace H A Cooper Jul 2025

Reflection On The ‘Power Of Us’ Conference: How Mainstream Schools In England Offer Provision To Children With Special Educational Needs (Sen), Grace H A Cooper

Plymouth Interdisciplinary Education Open Journal

The majority of children in England with Special Educational Needs or Disabilities (SEND) are educated within mainstream schools. Due to the broad range of needs of children, it is essential that mainstream schools are provided with adequate funding, preparation and training to ensure that the inclusion of every child is achievable and expected. Furthermore, sometimes schools feel that they cannot offer ample provision to give every child an equitable access to learning and therefore they are directed to SEND schooling – can a mainstream school be considered inclusive if they cannot support all children? This article will consider these arguments …


Making Our Voices Heard: Viewpoints Of Staff And Students At Chilton Bridge School, Emma Etherington Jul 2025

Making Our Voices Heard: Viewpoints Of Staff And Students At Chilton Bridge School, Emma Etherington

Plymouth Interdisciplinary Education Open Journal

Shared at the Power of Us Conference, this reflection explores my work as a Horticulture Practitioner at Chilton Bridge School, where I support SEN students through hands-on, nature-based learning. From planting trees to gaining qualifications in conservation, students are encouraged to learn in ways that suit them — practical, flexible, and rooted in the real world. This approach builds their confidence, self-esteem and sense of achievement. By listening to students and adapting to their individual needs, we create an environment where they feel included, valued, and capable, and where their voices are heard.


The Power Of Us: Reflections On Leadership, Inclusion And Change In Education, Meaghan Ryder-Green Jul 2025

The Power Of Us: Reflections On Leadership, Inclusion And Change In Education, Meaghan Ryder-Green

Plymouth Interdisciplinary Education Open Journal

This paper, originating from the ‘Power of Us!’ conference held in June 2025, reflects on different sessions exploring Exploring Leadership, Wellbeing, and Inclusion in Education. With a particular focus on the experiences of neurodivergent children and those with special educational needs and disabilities (SEND), the session highlighted the urgent need for systemic change. This paper offers an insight into the session, sharing reflections from the discussions and research findings—including the application of Seligman’s PERMA model of positive psychology and the importance of adult social-emotional learning—and calls for action to create a truly inclusive educational system that values all voices and …


‘They Actually Made Me Feel Like They Wanted Me In The Classroom’: Reflections Of Inclusion, Katherine Gulliver, George Osborne Jul 2025

‘They Actually Made Me Feel Like They Wanted Me In The Classroom’: Reflections Of Inclusion, Katherine Gulliver, George Osborne

Plymouth Interdisciplinary Education Open Journal

This article highlights the value of listening to individuals with lived experience in creating inclusive environments. Drawing on Gulliver’s (2023, 2024) research and the personal reflections of George Osborne, a disability advocate with Williams Syndrome, the article recognises the importance of early intervention, tailored support, and educator awareness in supporting children with rare disabilities. Through an awareness-raising exhibition and personal narratives, the article illustrates how inclusion can be meaningfully achieved when schools adapt to the needs of the child - rather than requiring the child to adapt to the school. George’s story demonstrates how empathetic, informed practice can help contribute …


Vive La Revolution, Hamish Kemp-Harington Jul 2025

Vive La Revolution, Hamish Kemp-Harington

Plymouth Interdisciplinary Education Open Journal

This article was written in response to the ‘Power of Us!’ conference which was held in May 2025 at the University of Plymouth. The conference focused on how we can make our schools and education systems more inclusive for the purpose of giving all students the opportunity to flourish and thrive in education. My account speaks of the preparation for the event and my own experiences in school as both a student and as an educator.


One Story, Jo Hawkes Jul 2025

One Story, Jo Hawkes

Plymouth Interdisciplinary Education Open Journal

This paper, originating from the ‘Power of Us!’ conference held in June 2025, reflects on the session titled One Story, which considered how stories can help us to learn about others. The paper offers an insight into the session, sharing reflections from the discussions and calling for a renewed attention to how we teach with literature and how we help children find a love of reading.


Power Of Us: Listening To Families, Tara J. Vassallo Jul 2025

Power Of Us: Listening To Families, Tara J. Vassallo

Plymouth Interdisciplinary Education Open Journal

This article, originating from the ‘Power of Us!’ conference held in June 2025, reflects on the session titled ‘Listening to families’ which offered an experienced parent panel, providing a forum for discussion. The session had a particular focus on the experiences of families and their children with neurodivergent and other individual educational needs and the families’ pursuit of genuine co-production with their children’s school. The article offers an insight into the session, sharing reflections from the discussions, and calls for action aimed at creating a truly inclusive educational system.


Creativity, Inclusion And Participation, Heather Knight Jul 2025

Creativity, Inclusion And Participation, Heather Knight

Plymouth Interdisciplinary Education Open Journal

This paper, originating from the ‘Power of Us!’ conference held in June 2025, reflects on the session titled ‘Creativity, Inclusion and Participation’, which drew upon different theories to explore what is creativity and question why many people believe they are not creative. This raises questions about what happens to creativity and what is the role that education plays in developing or hindering creativity. The paper offers an insight into the session, sharing reflections from the discussions, and exploring the idea that creativity can be seen as a democratic and social process. It argues that everyone can be creative in the …


A Preston Bridge School (Pbs) Approach To Inclusive Multisport Practices Within Sen, Jack Smith Jul 2025

A Preston Bridge School (Pbs) Approach To Inclusive Multisport Practices Within Sen, Jack Smith

Plymouth Interdisciplinary Education Open Journal

This paper, originating from the ‘Power of Us!’ conference held in June 2025, reflects on the session titled A Preston Bridge School Approach To Inclusive Multisport Practices Within SEN, which captured the current physical provision offer at Preston Bridge, with a particular focus on how the implementation of inclusive practices enable young people with SEN to meet and achieve their EHCP targets through physical education. The paper offers an insight into the session delivered, sharing best practice, staff and student reflections, and calls for action to promote the inclusion of young people with SEN within the context of physical education.


Positive Psychology And Positive Education: A Strengths-Based Approach To Sen, Michelle Y. Tytherleigh Jul 2025

Positive Psychology And Positive Education: A Strengths-Based Approach To Sen, Michelle Y. Tytherleigh

Plymouth Interdisciplinary Education Open Journal

This paper, originating from the ‘Power of Us!’ conference held in June 2025, reflects on the session titled: Positive psychology and positive education: a strengths-based approach to SEN, which looked at how positive psychology and positive education can be applied to better support students, and with a particular focus on those with SENs.The paper offers an insight into the session, sharing reflections from the discussions and research findings, and calls for action to create a truly inclusive educational system.


Collaborating Through Place-Based Partnerships For Inclusion, Suanne Gibson Jul 2025

Collaborating Through Place-Based Partnerships For Inclusion, Suanne Gibson

Plymouth Interdisciplinary Education Open Journal

This reflective paper presents thoughts and insights from an interactive session delivered by Professor Suanne Gibson at this year’s ‘The Power of Us’ Spaghetti Bridge with University of Plymouth conference, on May 1st.

Suanne reflects on how her talk ‘Plymouth’s story: Place-based school improvement for inclusion 2021 onwards’ took shape, telling the tale of a city’s successful progression for inclusion via a series of cross city and cross sector partnerships and collaborations. Matters of educational leadership and effective management of inclusive ideals, innovative practices and policies for progress and evidenced impact across Plymouth are shared and critically considered. …


Developing A Dynamic Learning Community – A Values Based Inclusive Approach To Relational School Leadership, Kulvarn Atwal Jul 2025

Developing A Dynamic Learning Community – A Values Based Inclusive Approach To Relational School Leadership, Kulvarn Atwal

Plymouth Interdisciplinary Education Open Journal

This paper, originating from the ‘Power of Us!’ conference held in June 2025, reflects on the session titled 'Developing a Dynamic Learning Community - a values based inclusive approach to relational school leadership' with a particular focus on the power of professional learning in creating an inclusive, high performing learning environment for all students. The paper offers an insight into the session, sharing reflections from the discussions and research findings, and calls for action to create a truly inclusive educational system, led by inclusive school leaders.


Foreword To The Special Issue: The Power Of Us Conference, Christopher Lore, Harriet Dismore Jul 2025

Foreword To The Special Issue: The Power Of Us Conference, Christopher Lore, Harriet Dismore

Plymouth Interdisciplinary Education Open Journal

This introduction to the special issue of the Plymouth Institute of Education Open Journal summarises the thinking behind the organisation of the Power of Us Conference held at the University of Plymouth on May 1st, 2025. The theme of the conference was creating more inclusive schools and communities through fostering dialogue between all participants in inclusive spaces: students, families, local authorities, community organisations, leaders, and numerous others. This conference can form a model for creating other inclusive spaces for sharing best practice and enabling as many voices as possible to be heard.


Editorial - Conference Proceedings And Reflections, Alicja Syska, Claudia Blandon, Katherine Gulliver, James Tarling, Jo Hawkes Jul 2025

Editorial - Conference Proceedings And Reflections, Alicja Syska, Claudia Blandon, Katherine Gulliver, James Tarling, Jo Hawkes

Plymouth Interdisciplinary Education Open Journal

This editorial introduces a special issue that documents 'The Power of Us' conference on inclusive education (1 May 2025, Spaghetti Bridge and University of Plymouth) through an innovative format that captures a wide spectrum of scholarly exchange. Rather than presenting traditional abstracts and formal papers, these proceedings privilege the voices and experiences that emerged in real time -audience reflections, presenter insights, and the emotional and intellectual responses that shaped the day's conversations. The editorial outlines the rationale for this approach, positioning it as a more complete representation of how knowledge about inclusive education is co-created through dialogue between diverse stakeholders. …


Husbandry And Management Interventions For The Conservation And Welfare Of Captive Animals – A Systematic Evidence Map, Anaelle Lemasson Lemasson Jul 2025

Husbandry And Management Interventions For The Conservation And Welfare Of Captive Animals – A Systematic Evidence Map, Anaelle Lemasson Lemasson

School of Biological and Marine Sciences

Zoos and aquariums are poised to play increasingly important roles in mitigating the global biodiversity crisis. However, the ultimate success of ex-situ conservation depends on animal welfare and effective husbandry and management practices. As such, an empirical understanding of ‘what works’ in zoo management is crucial for guiding success and embedding cost-effective practices. Here, we present the first systematic evidence map for husbandry and management interventions used in zoos and aquariums. We identified and extracted 1,070 articles spread across 45 journals, and examined patterns within taxonomic, spatial, temporal, and thematic categories. Studies originated from 516 institutions in 69 countries, and …


Making Intra-Urban Monitoring ‘A Walk In The Park’: A Mobile Monitoring Approach For Assessing Pedestrians’ Environmental Conditions, Cho Kwong Charlie Lam, Halat Alnaqshabandy, Shaun Lewin, Jack Morewood, Xiaoxiong Xie, Steve Goodhew Jul 2025

Making Intra-Urban Monitoring ‘A Walk In The Park’: A Mobile Monitoring Approach For Assessing Pedestrians’ Environmental Conditions, Cho Kwong Charlie Lam, Halat Alnaqshabandy, Shaun Lewin, Jack Morewood, Xiaoxiong Xie, Steve Goodhew

School of Art, Design and Architecture

Heat island effects and air pollution influence urban climates and air quality, impacting pedestrians’ health, comfort, and well-being. This study develops and pilots the Trolley-based Environmental Monitoring System (TEMS), which was validated in a medium-sized city in the UK. Three monitoring campaigns took place during May and June 2024. The mobile transects covered the city's built and natural environments, including high-density university buildings, museum precinct, medium-density dwellings, highways, and two parks. Appropriate apparatus was specified to monitor environmental variables integrated into a trolley that was easily operated by a single pedestrian. Fisheye photographs were taken to calculate the sky view …


Description Of The Combined Evidence-Based, Theory-Based And Person-Based Approaches Used To Develop A Behavioural Intervention Package To Support Non-Allergist Healthcare Workers To Remove Incorrect Penicillin Allergy Records From Medical And Surgical Adult Inpatients In A Uk Hospital, Neil Powell, Mathew Upton, Bridie Kent, Jonathan Sandoe, Sarah Tonkin-Crine Jul 2025

Description Of The Combined Evidence-Based, Theory-Based And Person-Based Approaches Used To Develop A Behavioural Intervention Package To Support Non-Allergist Healthcare Workers To Remove Incorrect Penicillin Allergy Records From Medical And Surgical Adult Inpatients In A Uk Hospital, Neil Powell, Mathew Upton, Bridie Kent, Jonathan Sandoe, Sarah Tonkin-Crine

School of Biomedical Sciences

Objectives To develop a behavioural intervention package to support non-allergist healthcare workers (HCWs) to remove incorrect penA records from medical and surgical adult inpatients. This paper describes the development of the penicillin allergy de-labelling (PADL) intervention and the implementation intervention that will support non-allergist-delivered PADL. Design We combined evidence-based, theory-based and person-based approaches. Qualitative research with healthcare professionals and patients explored barriers and enablers to implementation of the proposed PADL pathway. Key intervention design objectives and the key features of the implementation intervention required to achieve each objective were then developed and captured as guiding principles. We produced a logic …


Protective Multi-Stressor Interactions In The Anthropocene: Key Considerations For Investigating Cross-Tolerance In A Conservation Context, Essie M Rodgers, Simone Baldanzi, Michael Collins, W Wesley Dowd, Lauric Feugere, Giovanna Mottola, Fanny Vermandele, Daniel F Gomez Isaza Jul 2025

Protective Multi-Stressor Interactions In The Anthropocene: Key Considerations For Investigating Cross-Tolerance In A Conservation Context, Essie M Rodgers, Simone Baldanzi, Michael Collins, W Wesley Dowd, Lauric Feugere, Giovanna Mottola, Fanny Vermandele, Daniel F Gomez Isaza

School of Biological and Marine Sciences

In the Anthropocene, species are increasingly faced with multiple stressors that are more severe and less predictable than before. While multiple stressors often interact to affect organisms negatively, sometimes these interactions can be beneficial, enhancing resilience through cross-protection. Cross-protection interactions occur when exposure to one stressor, such as elevated temperature, enhances an organism’s tolerance to a different stressor, like hypoxia, through shared protective mechanisms or signaling pathways. Understanding the potential for cross-protection to combat rapid and diverse environmental change is crucial for conservation, as it potentially alters the predicted consequences of such change. Here, we outline 10 key considerations for …


A Survey Of Image Forensics: Exploring Forgery Detection In Image Colorization, Saurabh Agarwal, Deepak Sharma, Nancy Girdhar, Cheonshik Kim, Ki-Hyun Jung Jul 2025

A Survey Of Image Forensics: Exploring Forgery Detection In Image Colorization, Saurabh Agarwal, Deepak Sharma, Nancy Girdhar, Cheonshik Kim, Ki-Hyun Jung

School of Engineering, Computing and Mathematics

In today’s digital era, the rapid evolution of image editing technologies has brought about a significant simplification of image manipulation. Unfortunately, this progress has also given rise to the misuse of manipulated images across various domains. One of the pressing challenges stemming from this advancement is the increasing difficulty in discerning between unaltered and manipulated images. This paper offers a comprehensive survey of existing methodologies for detecting image tampering, shedding light on the diverse approaches employed in the field of contemporary image forensics. The methods used to identify image forgery can be broadly classified into two primary categories: classical machine …


A Comprehensive Review On Machine Learning-Based Job Recommendation Systems, Shaymaa Al-Juboori, Su-Cheng Haw, Rui Ern Yap Jul 2025

A Comprehensive Review On Machine Learning-Based Job Recommendation Systems, Shaymaa Al-Juboori, Su-Cheng Haw, Rui Ern Yap

School of Engineering, Computing and Mathematics

A dynamic, constantly shifting labor market creates enormous job postings, overwhelming candidates and making it difficult for businesses to find quality candidates. It is also hard for job seekers to find suitable jobs. Addressing these issues, machine learning-driven job recommender systems have recently become an essential tool using predictivemodels to improve the match between jobs and candidates. A hybrid design that combine scollaborative filtering with content-based filtering andadds contextual information like geographic location,industry trends, and user behavioural data can enhance the accuracy and relevance of recommendations. This paper reviews and critically analyzes contemporary jobre commender system techniques. The focus is …


Early Childhood Education – A Unique And Quasi-Hidden Curriculum, Verity Campbell-Barr Jul 2025

Early Childhood Education – A Unique And Quasi-Hidden Curriculum, Verity Campbell-Barr

School of Law, Humanities and Social Sciences

This paper considers the complexities and debates surrounding the concept of curriculum in Early Childhood Education (ECE). The paper highlights the tension between traditional, structured curriculum models found in schooling and the more flexible, child-centred and play-based approaches advocated in ECE. Starting from the premise that curriculum theory in ECE is underdeveloped, the discussion draws on Bernstein’s Pedagogic Device to provide a theoretical framework with which to analyse how knowledge is produced and recontextualised in ECE in both the official (state) and pedagogic field. Central to the recontextualisation are theories of child development and how they provide an underlying course …


Assessing The Effects Of Antibiotic Selectivity And Temperature On The Antimicrobial Activity Of Isolates Derived From The Deep-Sea Sponge Pheronema Capenteri, Lex L. Hilario Jul 2025

Assessing The Effects Of Antibiotic Selectivity And Temperature On The Antimicrobial Activity Of Isolates Derived From The Deep-Sea Sponge Pheronema Capenteri, Lex L. Hilario

The Plymouth Student Scientist

The rapid increase of antibiotic resistance necessitates the discovery of novel antibiotic compounds capable to tackle these resistant bacteria. Deep-sea sponges accommodate a diverse and dense microbiome filled with an array of bacterial communities that have the potential to produce novel antimicrobials. Some discovered novel strains have already shown their capability in producing secondary metabolites that are effective against clinically relevant strains. This study aims to evaluate the impacts of different culture conditions; antibiotic selectivity and temperature, on the antimicrobial activity of isolates recovered from three different Pheronema carpenteri deep-sea sponges. Using culture-dependant methods, a total of 59 bacterial isolates …


Comparing P62 And Lc3 As Autophagy Biomarkers: Insights Into Cellular Homeostasis, Riya Roychan Jul 2025

Comparing P62 And Lc3 As Autophagy Biomarkers: Insights Into Cellular Homeostasis, Riya Roychan

The Plymouth Student Scientist

Autophagy is a fundamental cellular process that maintains homeostasis by the degradation of damaged organelles and proteins. It plays crucial roles in cellular remodelling, development, and disease progression. These roles apply to the study of neurodegenerative diseases which is heavily linked to the toxicity produced by unwarranted accumulation of cellular material. A key player in autophagy is LC3, which translocate to autophagosomal membranes during the process. Detecting fluorescently labelled LC3-II through immunofluorescence provides a valuable method for assessing autophagy levels in samples. In a similar premise p62, also known as sequestosome-1 (SQSTM-1), is an adaptor between LC3 and ubiquitinated substrates, …