Digital Commons Network^™

Early Phase Testing Of Functional Imagery Training As An Intervention For Anxiety, Jackie Andrade, D. J. Kavanagh, Carly Bowditch, Emily Mackriel, Emily Ravenshill, Amy Sime, Eleanor Trumfield, Jessica Watts, Jon May

School of Psychology

Cognitive models hypothesize a role for motivated behaviour in anxiety disorders, with safety behaviours leading to exaggerated threat appraisals and increased anticipatory anxiety. Based on the Affective Imagery Theory of Motivation, we propose that increasing motivation for engagement behaviours will reduce motivation for safety behaviours through competition for limited capacity cognitive resources supporting motivational imagery. We hypothesise that imagining successful engagement will reduce anxiety directly, and through promoting subsequent engagement. We present preliminary evidence that functional imagery training (FIT), an intervention that develops and teaches motivational imagery, reduces anxiety. FIT was delivered to undergraduates with anxiety in one session lasting …

A Qualitative Analysis Of How Just Stop Oil Protests Are Framed In The Uk Online News Media, Holly Handy

The Plymouth Student Scientist

Previous research has found that when the news media reports on demonstrations, protest groups can be subject to delegitimising coverage. This body of research can be subsumed under Chan & Lee’s “protest paradigm” and is believed to consist of a set of narrative frames that journalists default to in the coverage of protests. Recent research demonstrates how the use of these framing devices may be in decline and advocates for a more integrated approach to protest coverage. However, there is little research that uses analytic frameworks specifically theorised to explore media framing. This study uses Giles and Shaw’s media framing …

Advancing Statistical Literacy In Eye Care: A Series For Enhanced Clinical Decision-Making: Part 2: Statistical Testing In Eye And Vision Research – Principles And Practices, Daniela Oehring

School of Health Professions

Purpose: To enhance statistical literacy in eye and vision Research through practical guidance on hypothesis testing, test selection, and interpreting inferential statistics. The goal is to reduce common analytical errors and support more clinically meaningful conclusions in ophthalmic studies.Material and Methods: A narrative literature review was conducted using PubMed, Scopus, and Web of Science to identify best practices in hypothesis testing, error control, and test selection relevant to clinical research in ophthalmologyand optometry. Simulated datasets, based on real-world clinical scenarios, were generated in Python to illustrate core concepts. Worked examples demonstrate the Impact of sample size, data distribution, and error …

First Permanent Molar Root Canal Configurations In A South African Sample: A Descriptive Micro-Computed Tomographic Report, Casper Jonker, Guy Lambourn, Peet Van Der Vyver, Theye Charlotte, Federico Foschi, Ericka Noelle L’Abbé, Anna Catherina Oettlé

Peninsula Dental School

The aim of this paper was to describe root canal configurations using micro-CT in South African first molars. A segmentation process was followed on micro-focus X-ray computed tomography (micro-CT) scans of 101 maxillary and 86 mandibular first molars. Main and accessory root canal anatomy were considered to describe root canal configurations of South African first molars. Intra- and inter-observer reliability was determined using the unweighted Cohen’s Kappa test. Intra- and inter-rater agreement was 93% for maxillary configurations; 92.9% and 86.2% respectively for mandibular configurations. The most common main canal configurations were: 3MXFM MB1DB1P1 (n = 33/93, 35.5%) and 2MDFM M1-2D1 …

Using A Realist Informed Qualitative Approach To Elaborate Programme Theory: Experiences From The Feasibility Phase Of The D-Pact Project., Sarah Griffiths, Hannah Wheat, Sarah Morgan-Trimmer, Lauren Weston, Alex Gude, Tomasina Oh, Rod Sheaff, Richard Byng

Peninsula Medical School

Realist approaches to complex health care evaluations are increasingly used and recommended in national evaluationguidelines. However, there remains a paucity of researcher guidance on methods for elaborating and refining programmetheories throughout the stages of a realist evaluation project—from prospective theory development to feasibility work,to full evaluation. We present a step by step worked example of a realist approach to elaborating a programme theory for ahealth care intervention during the feasibility phase of the Dementia PersonAlised care Team. We explain how multiplequalitative methods can be applied to elaborate initial theory, supporting a shift away from a hypothetical explanation, towards a theory …

Triage Of Road Injury Casualties - The Role Of Bystanders: A Scoping Review, George Stephen Russam, Jake Gluyas-Harris, Nicholas Aveyard, Tim Nutbeam

Peninsula Medical School

Background: Bystanders have the potential to be a critical component of the Road Injury Chain of Survival, particularly in the early phases of injury recognition, scene assessment, and emergency service activation. Their potential role in trauma triage remains underexplored. This scoping review aims to examine the existing evidence of the use of bystanders in triage—both laypersons and non-clinical professionals—during the prehospital phase of road injury and other trauma scenarios. Methods: A systematic search was undertaken across MEDLINE, CINAHL, and the Psychology & Behavioural Sciences Collection using the EBSCO Host platform, with supplementary hand searches via Google Scholar and reference screening. …

Small Scale Analysis Of Urban Air Quality And Public Health In London, Uk, Provides Insights For Targeted Interventions, Alan Smith, Tim Daley

School of Geography, Earth and Environmental Sciences

Understanding the impact of scale and zonation is critical for accurately assessing population health in relation to air quality and demographic data. Using existing census geographies, we analyse spatial clustering and statistical associations across different census scales, focussing on vulnerable sociodemographic groups and temporal exposure patterns. This study aims to assess how different spatial resolutions affect the strength and interpretation of associations between air pollution, sociodemographic variables, and self-reported health. It also evaluates whether finer-scale, health-need-based zoning provides a more accurate basis for public health analysis. Exposure to higher PM2.5 concentrations, and having an undrlying disability, or long-term illness shows …

Prioritising Time-Critical Injuries And Interventions For Trapped Motor Vehicle Collision Patients: A Delphi Study, Tim Nutbeam, Rob Fenwick, Ian Marritt, Brian Lee, Luke Staveley-Wadham, Nigel Lang, Louise Johnson, Nicolas Mattock, Jane Ogilvie, Emily Foote, Francis Screech, Lara Lebeau–Humarau, Caroline Leech

Peninsula Medical School

Background Physically trapped patients following motor vehicle collisions are at high risk of time-critical injuriesand poor outcomes. Despite this, there is limited consensus on which injuries should be prioritised and which earlyinterventions are both necessary and feasible in the prehospital setting. This study aims to develop expert consensuson injury categorisation and the delivery of early care interventions to guide clinical and operational decision-makingat the scene.Methods A modified Delphi method was used to gather consensus from a multidisciplinary panel of subjectmatter experts, including clinicians, paramedics, and members of fire and rescue services. In Round 1, participantscontributed to the development of draft …

A Potential New Sea Surface Temperature Proxy Based On Isomeric Highly Branched Isoprenoid Lipid Biomarkers: Ez25, Simon T. Belt, Lukas Smik, Katrine Husum, Jochen Knies

School of Geography, Earth and Environmental Sciences

Two tri-unsaturated and isomeric (E/Z) highly branched isoprenoid (HBI) diatom lipid biomarkers were quantified in 228 water column samples collected from the English Channel, West Svalbard (Arctic), the Scotia Sea (Southern Ocean) and East Antarctica. We found that the relative amounts of the two HBIs correlate well with water temperatures taken at the time of sampling. Based on these findings and some other HBI data reported previously, we suggest that the proportion of the HBI E-isomer (termed EZ25) may serve as a new proxy for palaeo sea surface temperatures, including in the polar regions. Next steps will involve determination of …

Modeling The Effects Of Cyclical Masticatory Forces In A 3d Oral Mucosal Model In Vitro, Samantha Robins, Vehid Salih, Alastair Lomax, Sian Crow, Zoe Brookes, Andrew Foey, Simon A. Whawell

Peninsula Dental School

This study describes the development of a three-dimensional (3D) oral mucosal model (OMM) to investigate how oral tissues respond to masticatory forces. The OMMs replicated key features of human oral mucosa, such as stratified keratinocyte telomerase-immortalized gingival keratinocytes (TIGK) layers and fibroblast-populated collagen matrices. Cyclical mechanical forces (0-10 N) for 2 h applied to the model caused force-dependent changes in the histological structure, including thinning of the epithelium and collagen matrix and cell displacement at higher forces. Lactate dehydrogenase (LDH) cytotoxicity assays revealed that 10 N forces led to significant cell damage (about 50% cell death) in TIGK monolayers, whereas …

From Livestream To Table: Psychological Drivers Of Purchase Intention In Restaurant Livestreaming, Qingchuo Zhang, Rong Huang, Qian Chen, Jinhua Zhang

Plymouth Business School

Purpose – Restaurant livestreaming, where consumers interact with real-time digital content that promotesphysical dining experiences, has emerged as a distinctive form of digital marketing. It integrates onlineengagement with offline consumption in a novel way.Design/methodology/approach – Thisstudy builds upon the stimulus-organism-response (S-O-R) framework.It incorporates insights from flow theory and perceived value theory to examine how emotional immersion andcognitive evaluation influence consumer purchase intentions in the context of restaurant livestreaming.A structural model is then tested using survey data collected from 482 livestream consumers.Findings – Using a sequential mixed methods design, this study first identifies key environmental stimuli throughin-depth interviews. These stimuli include …

Towards A Modular Compliant Actuator Toolkit, Oliver Smith, Swen E. Gaudl, Pablo Borja

School of Engineering, Computing and Mathematics

Compliant Actuators differ from traditional Servo Actuators via the ability to sense and control for forces, in addition to position and velocity. A multitude of concepts exist: force-torque control of brushless DC motors, Series Elastic Actuators (SEAs) featuring a physical elastic element, and Variable Stiffness Actuators (VSA), which use a stiffness control mechanism to modulate the physical stiffness of the elastic element. However, due to the complexity, variety, and prohibitive cost of parts and fabrication, there is a lack of reproduction, which hinders the, development, adoption, and application of such devices. This paper introduces the concept of a Modular Compliant …

Core Outcome Set And Measures Of Chest Health In Children And Young People With Cerebral Palsy In The Community Setting: The Chesti Study Protocol, Chesti-Study Steering Group, Rachel Knight Lozano, Christopher Morris, Harriet Shannon, Kayleigh Bell, Hugh Malyon, Julia Melluish, Jos Latour, Morag Andrews, Sarah Crombie, Noula Gibson, Samantha Grace, Sian Goddard, Nicola Harman, Sarah Mc Goldrick Kolawole, Laura Lowndes, Paul Mcnamara, Madeline Pilbury, Rachel Rapson, Nicola Scivier, Diane Sellers, Caroline Weighton, Mark Williams, Luana Winston

School of Health Professions

Introduction Poor chest health is the leading cause of early mortality in children with cerebral palsy (CP). It is also the most common reason to seek healthcare, accruing significant costs and reducing quality-of-life for children and families. Clinical trials examining chest health interventions in CP are characterised by inconsistent outcome measures, limiting the capacity for evidence synthesis to inform clinical application. The study aims to develop a core outcome set (COS) and related measurement instruments to assess, monitor and evaluate chest health in children with CP, both in research and routine clinical practice. The COS will reflect the views of …

Investigating Techniques To Optimise The Layout Of Turbines In A Windfarm Using A Quantum Computer, James Hancock, Matthew Craven, Craig Mcneile, Davide Vadacchino

School of Engineering, Computing and Mathematics

This paper investigates Windfarm Layout Optimization (WFLO), where we formulate turbine placement considering wake effects as a Quadratic Unconstrained Binary Optimization (QUBO) problem. Wind energy plays a critical role in the transition toward sustainable power systems, but the optimal placement of turbines remains a challenging combinatorial problem due to complex wake interactions. With recent advances in quantum computing, there is growing interest in exploring whether hybrid quantum-classical methods can provide advantages for such computationally intensive tasks. We investigate solving the resulting QUBO problem using the Variational Quantum Eigensolver (VQE) implemented on Qiskit’s quantum computer simulator, employing a quantum noise-free, gate-based …

Multi-Objective Optimisation Of Floating Offshore Wind Farms Based On A Real-World Case Study, Pawel Manikowski, David Walker, Matthew Craven

School of Engineering, Computing and Mathematics

In this paper, we used real data to predict the position of the floating wind turbines due to three external forces: wind, wave and current. We analysed data provided by energy company Equinor and applied two machine-learning techniques: Multilayer Perceptron and Random Forest. After demonstrating that machine learning models failed, we used a simple linear regression model and optimisation approach to solve the multi-objective optimisation problem. We minimised the perimeter of the wind farm and maximised its power output by applying the multi-objective optimisation algorithm NSGA-II. We also investigated how changing the length of mooring lines affected the optimisation. We …

Optimising The Care Of The Trapped Patient Following A Motor Vehicle Collision: A Uk-Based Delphi Consensus Study, Tim Nutbeam, Rob Fenwick, Ian Marritt, Brian Lee, Luke Staveley-Wadham, Nigel Lang, Louise Johnson, Nicolas Mattock, Jane Ogilvie, Emily Foote, Francis Screech, Lara Lebeau-Humarau, Caroline Leech

Peninsula Medical School

Background Motor vehicle collisions (MVCs) are a leading cause of injury and death worldwide. Up to 40% ofcasualties may become trapped and entrapment is associated with delayed care and worse outcomes. There is littlenational or international consensus guiding the care of physically trapped patients who cannot self-extricate. Thisstudy aimed to develop multidisciplinary consensus-based principles to optimise clinical and operational care fortrapped patients following MVC.Methods A three-round Delphi study was conducted from January to March 2025, following the CREDES framework.A multi-professional steering group developed preliminary statements informed by literature review and expertconsultation. Subject matter experts (SMEs) with operational experience in extrication, …

Post-Pandemic Restaurant Patronage: The Importance Of Neuroticism In Shaping In Person Dining Intentions., Matthew Gorton, Min Yan, Honglyu Lin, Dora Gaćeša Brlić, John White, Ružica Brečić, Ana Tkalac Verčič

Plymouth Business School

Purpose Even after the lifting of all government restrictions, introduced to combat the spread of Covid-19, many consumers remain fearful of in-person dining. This paper seeks to understand this reticence, and explain post-pandemic restaurant dining intentions. Design/methodology/approach The paper introduces and tests a conceptual framework for understanding in-person dining intentions in the post-Covid-19 era, utilizing structural equation modelling. To empirically validate the model, survey data collection (n = 436) occurred in China after the government lifted its “Zero-Covid” policy. Findings Neuroticism, as a personality trait, negatively affects restaurant trust and increases fear of Covid-19 (threat appraisal), which in turn reduces …

Advancing Generative Ai For Music With Photonics, Eduardo Miranda, Siegelwax Brian

School of Art, Design and Architecture

This paper presents PhotoSing, a system that learns to generate polyphonic tunes by extracting sequencing rules from given examples. We developed a method to encode given pieces of music in terms of unique musical events, referred to as UMEs, and stochastic rules for sequencing them. Those rules are subsequently converted into representations to be processed by a photonic computer to generate new compositions. This research builds upon a previous system, QuSing, which generated monophonic tunes with superconducting quantum computing. The paper discusses the pitfalls of the previous system, the research and the solutions developed to improve them. It details the …

Ai-Driven Biomedical Perspectives On Mental Fatigue In The Post-Covid-19 Era: Trends, Research Gaps, And Future Directions, Saba Parveen, Md Belal Bin Heyat, Umair Tariq, Faijan Akhtar, Hafiz Muhammad Zeeshan, Seth Christopher Yaw Appiah, Shang-Ming Zhou, Huang Lei

School of Nursing and Midwifery

Mental fatigue is a complex condition arising from various neurological processes and influenced by external factors such as stress and cognitive demands. This comprehensive review elucidates the primary neurological mechanisms underlying mental fatigue, particularly emphasizing how it was elevated or otherwise affected during the COVID-19 pandemic. We explore the intricate relationship between prolonged cognitive tasks, chronic stress, and the development of mental fatigue, emphasizing the impacts that mental fatigue has on mental health across diverse populations. Utilizing advanced artificial intelligence techniques, including machine learning and deep learning, this study identifies and quantifies the patterns of mental fatigue. The innovative approach …

The Educator Becomes The Student: Achieving Lifelong Learning Through Daybook, Casper Jonker, Zoe Brookes, Catherine Coelho, Sally Hanks, Amanda Addy

Peninsula Dental School

No abstract provided.

From Age Estimation To Age-Invariant Face Recognition: Generalized Age Feature Extraction Using Order-Enhanced Contrastive Learning, Haoyi Wang, Victor Sanchez, Chang Tsun Li, Nathan Clarke

School of Engineering, Computing and Mathematics

Generalized age feature extraction is crucial for age-related facial analysis tasks, such as age estimation and age-invariant face recognition (AIFR). Despite the recent successes of models in homogeneous-dataset experiments, their performance drops significantly in cross-dataset evaluations. Most of these models fail to extract generalized age features as they only attempt to map extracted features with training age labels directly without explicitly modeling the natural ordinal progression of aging. In this paper, we propose Order-Enhanced Contrastive Learning (OrdCon), a novel contrastive learning framework designed explicitly for ordinal attributes like age. Specifically, to extract generalized features, OrdCon aligns the direction vector of …

Parent's Help-Seeking For, And Care Of, A Sick Or Injured Child During Covid-19 Pandemic Lockdowns: A National Online Survey In Türkiye, Bahar Aksoy, Sarah Neill

School of Nursing and Midwifery

Aim: This study aimed to investigate how COVID-19 lockdowns in Türkiye influenced parents' actions when their child was ill or injured and how they perceived the impact of the lockdown on the severity of their child's illness and the treatment received. Methods: This descriptive, and cross-sectional mixed method was conducted with 104 parents whose children experienced illness or injury during the pandemic lockdowns between July and September 2022. Data was collected through online survey using snowball sampling method. Descriptive statistics and pearson's chi-square test were used for statistical analysis, while free-text data was subjected to thematic analysis. Results: Of the …

An Assessment Model For Linking Changes In Pelagic Habitat State To Impacts On Human Wellbeing, Matthew P. Faith, Siân E. Rees, Angus Atkinson, Mike Best, Eileen Bresnan, Michelle J. Devlin, Matthew M. Holland, Holly J. Niner, Clare Ostle, Paul Tett, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

Plankton monitoring datasets help inform indicators for marine biodiversity assessments under the European Union Marine Strategy Framework Directive and United Kingdom Marine Strategy. These indicators are used to assess long-term changes in the state of the pelagic habitats of the Northeast Atlantic which then guide policy formation and implementation to achieve Good Environmental Status. Across all ecosystems, environmental change has the potential to impact upon human wellbeing by changing the quantity and quality of ecosystem services. Here, we develop a socio-ecological assessment model that can describe how variations in pelagic habitat state, evidenced by plankton indicators, can impact human wellbeing. …

Relativistic Quantum Kinetic Theory: Higher Order Contributions In Assisted Schwinger Pair Production, James P. Edwards, Naser Ahmadiniaz, Sebastian M. Schmidt, Christian Kohlfürst

School of Engineering, Computing and Mathematics

Quantum kinetic theory is an important tool for studying nonequilibrium, nonperturbative and nonlinear interactions within an open quantum system, and as such is able to provide an unprecedented view on particle production in the relativistic, ultrahigh intensity regime of quantum electrodynamics. By reorganizing the relativistic quantum transport equations for Abelian plasmas and integrating them with a perturbative expansion, we significantly expand the scope for kinetic theories to further elucidate the peculiarities of particle production at a spectral level.

Contrasting Responses To Riverine Barrier Modification And Fish Pass Provision In Two Anadromous Non-Salmonid Species During Their Spawning Migrations, Mark I.A. Yeldham, J. Robert Britton, Charles Crundwell, Peter Davies, Jamie R. Dodd, Chris Grzesiok, Andrew D. Nunn, Randolph Velterop, Jonathan D. Bolland

School of Biological and Marine Sciences

Anthropogenic in-river structures represent barriers to migrating fishes. Fish pass designs usually focus on passing anadromous salmonids, and fish pass studies usually focus on site-scale metrics, failing to consider the wider effects. Weir passage metrics and spawning distributions of anadromous iteroparous twaite shad Alosa fallax and semelparous sea lamprey Petromyzon marinus were assessed using acoustic telemetry between 2018 and 2023, within a catchment-scale reconnection programme on the River Severn (‘Unlocking the Severn’ [UtS]). Reconnection was by fish pass installation (Severn mainstem; 3 deep-vertical slot (DVS), 1 column bypass) and weir modification (Teme tributary; 1 partial removal/reduced head height, 1 reduced …

Genetic Overlap Between Functional Impairment And Depression And Anxiety Symptom Severity: Evidence From The Glad Study, Megan Skelton, Jessica Mundy, Abigail Ter Kuile, Brett Adey, Cherie Armour, Joshua Buckman, Jonathan Coleman, Molly Davies, Colette R. Hirsch, Matthew Hotopf, Ian Jones, Gursharan Kalsi, Georgina Krebs, Sang Hyuck Lee, Yuhao Lin, Andrew M. Mcintosh, Alicia J. Peel, Christopher Rayner, Katharine Rimes, Daniel J. Smith, Katherine N. Thompson, David Veale, James T.R. Walters, Christopher Hübel, Gerome Breen, Thalia C. Eley

School of Psychology

BACKGROUND: Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairment are partially distinct, functional impairment is often overlooked. To assess whether functional impairment captures diagnostically relevant genetic liability beyond that of symptoms, we aimed to estimate the heritability of, and genetic correlations between, key measures of current depression symptoms, anxiety symptoms, and functional impairment.

METHODS: In 17,130 individuals with lifetime depression or anxiety from the Genetic Links to Anxiety and Depression (GLAD) Study, we analyzed total scores …

Conservative Oxygen Therapy In Mechanically Ventilated Critically Ill Adult Patients: The Uk-Rox Randomized Clinical Trial, Uk-Rox Investigators, Daniel S Martin, Doug W Gould, Tasnin Shahid, James C Doidge, Alex Cowden, Zia Sadique, Julie Camsooksai, Walton N Charles, Miriam Davey, Amelia Francis-Johnson, Roger M Garrett, Michael P W Grocott, Joanne Jones, Lamprini Lampro, Diane M Mackle, B Ronan O'Driscoll, Alvin Richards-Belle, Anthony J Rostron, Tamás Szakmány, Alex Warren, Paul J Young, Kathryn M Rowan, David A Harrison, Paul R Mouncey

Peninsula Medical School

IMPORTANCE: Supplemental oxygen is frequently given to patients in intensive care units (ICUs); however, there is insufficient evidence to guide its therapeutic use and to minimize the potential harm caused by administering too little or too much.

OBJECTIVE: To determine whether reducing exposure to supplemental oxygen through a strategy of conservative oxygen therapy by using a peripheral oxygen saturation (Spo2) target of 90% (range, 88%-92%) reduces mortality at 90 days in mechanically ventilated adult patients receiving supplemental oxygen in the ICU.

DESIGN, SETTING, AND PARTICIPANTS: Multicenter, pragmatic, randomized clinical trial conducted in 97 ICUs in the UK including 16 500 …

My A-T Pack: A Qualitative Study Of The Utility, Acceptability, Design, And Content Of A Family-Designed And Owned Information Pack Relevant To The Lives Of Children And Young People Living With Ataxia Telangiectasia, Lisa Bunn, Joanne Paton

School of Health Professions

BackgroundAtaxia Telangiectasia (A-T) is a rare genetic and progressive condition, primarily affecting the neurological, immunological, and pulmonary systems. In the absence of a cure, people living with A-T require co-ordinated multidisciplinary care to manage their complex needs. This often leads to families working with a range of different professionals and feeling burdened by the amount of information and coordination of care that they manage.With the aim to inform the co-production of a family-owned healthcare pack to promote person-centered care and self-management, this study explored the views of children with A-T and parents of children and young people with A-T about …

Transforming Business Management Placement Students Into Teachers, Carl Evans, Paul Harrington

Plymouth Business School

A period of work placement is widely recognised to be one of the most effective ways to enhance an undergraduate’s employability and work-readiness. However, at present, the value of all the learning gained on the work placement remains with the placement student. The authors of this viewpoint paper propose an approach to widen the benefits of a work placement, by sharing an element of industrial or commercial knowledge gained with fellow undergraduates and with teaching staff, via a delivered teaching presentation. In doing so, brings work experience to a wider group of undergraduates and strengthens the link between education and …

Nemvaleukin Alfa Monotherapy In Patients With Advanced Melanoma And Renal Cell Carcinoma: Results From The Phase 1/2 Non-Randomized Artistry-1 Trial, Emiliano Calvo, Valentina Boni, Olivier Dumas, Sang Joon Shin, Seth D Rosen, Arvind Chaudhry, Philip R Debruyne, Xiaomin He, Ulka N Vaishampayan, David F Mcdermott

School of Nursing and Midwifery

BACKGROUND: Despite improved outcomes with immune checkpoint inhibitors (ICIs) and their combinations in advanced solid tumors, a subset of patients remains unresponsive or progresses, highlighting an unmet need for novel treatments with durable benefit. Nemvaleukin alfa (nemvaleukin, ALKS 4230) demonstrated manageable safety and antitumor activity, alone and in combination with pembrolizumab, across heavily pretreated advanced solid tumors in the ARTISTRY-1 study. We report in-depth antitumor activity, safety, pharmacokinetics, and pharmacodynamics of nemvaleukin monotherapy at the recommended phase 2 dose (RP2D) in advanced melanoma and renal cell carcinoma (RCC) cohorts from ARTISTRY-1.

METHODS: ARTISTRY-1 was a three-part (A, B, and C), …