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A Practical Guide To Transcranial Ultrasonic Stimulation From The Ifcn-Endorsed Itrusst Consortium, Keith R. Murphy, Tulika Nandi, Benjamin Kop, Takahiro Osada, Maximilian Lueckel, W. Apoutou N'Djin, Kevin A. Caulfield, Anton Fomenko, Hartwig R. Siebner, Yoshikazu Ugawa, Lennart Verhagen, Sven Bestmann, Eleanor Martin, Kim Butts Pauly, Elsa Fouragnan, Til Ole Bergmann Mar 2025

A Practical Guide To Transcranial Ultrasonic Stimulation From The Ifcn-Endorsed Itrusst Consortium, Keith R. Murphy, Tulika Nandi, Benjamin Kop, Takahiro Osada, Maximilian Lueckel, W. Apoutou N'Djin, Kevin A. Caulfield, Anton Fomenko, Hartwig R. Siebner, Yoshikazu Ugawa, Lennart Verhagen, Sven Bestmann, Eleanor Martin, Kim Butts Pauly, Elsa Fouragnan, Til Ole Bergmann

School of Psychology

Low-intensity Transcranial Ultrasonic Stimulation (TUS) is a non-invasive brain stimulation technique enabling cortical and deep brain targeting with unprecedented spatial accuracy. Given the high rate of adoption by new users with varying levels of expertise and interdisciplinary backgrounds, practical guidelines are needed to ensure state-of-the-art TUS application and reproducible outcomes. Therefore, the International Transcranial Ultrasonic Stimulation Safety and Standards (ITRUSST) consortium has formed a subcommittee, endorsed by the International Federation of Clinical Neurophysiology (IFCN), to develop recommendations for best practices in human TUS applications. The practical guide presented here provides a brief introduction into ultrasound physics and sonication parameters. It …


Testing The Proteus Effect In Autistic And Neurotypical Participants, Chris Fullwood, Liam Cross, Gray Atherton, Darren Chadwick Mar 2025

Testing The Proteus Effect In Autistic And Neurotypical Participants, Chris Fullwood, Liam Cross, Gray Atherton, Darren Chadwick

School of Psychology

This study examined the Proteus effect in autistic and neurotypical participants via the video game, The Sims. Thirty-two participants (16 autistic, 16 neurotypical) participated in a free-play session of The Sims, playing as either an attractive or unattractive avatar. In line with predictions, participants who had played as the attractive avatar negotiated for a significantly larger share of a fictional pot of money during a post-play economic game. Further, participants who had used the attractive avatar engaged in significantly more exercise activities in-game and flirted more often with nonplayable characters. While there was some evidence to suggest that autistic people …


Gap Filling Crowdsourced Air Temperature Data In Cities Using Data-Driven Approaches, Miao He, Zhiwen Luo, Xiaoxiong Xie, Peng Wang, Haichao Wang, Gabriela Zapata-Lancaster Mar 2025

Gap Filling Crowdsourced Air Temperature Data In Cities Using Data-Driven Approaches, Miao He, Zhiwen Luo, Xiaoxiong Xie, Peng Wang, Haichao Wang, Gabriela Zapata-Lancaster

School of Art, Design and Architecture

Crowdsourced temperature data from citizen weather stations (CWS) in urban area offer valuable insights into intra-urban temperature distribution but are often challenged by a significant number of missing values. Existing gap-filling methods, typically effective for random gaps and low missing rates, are inadequate for the continuous gaps and high missing rates common in CWS recordings. This study introduces a novel data-driven approach to fill these gaps by modelling relationships between CWS data and official weather station (OWS) records during periods of data availability. We evaluate various feature sets and data-driven algorithms, including Multiple Linear Regression (MLR), Random Forest (RF), and …


Should Oral Examination Be Reimagined In The Era Of Ai?, Prashanti Eachempati, Ramnarayan Komattil, Arathi Arakala Mar 2025

Should Oral Examination Be Reimagined In The Era Of Ai?, Prashanti Eachempati, Ramnarayan Komattil, Arathi Arakala

Peninsula Dental School

As artificial intelligence (AI) continues to reshape education, concerns about the authenticity of student work have escalated, particularly in relation to written assignments influenced by AI-powered tools. This article explores the role of the oral examination as a valuable method for assessing true student understanding and considers its potential for broader use across various educational levels. We propose that oral exams could be effectively integrated into undergraduate courses, providing a means to verify student comprehension in an era of AI-generated content. By adopting oral assessments, educators can enhance academic integrity while fostering essential skills such as critical thinking and effective …


Early Cretaceous Giant Glendonites: A Record Of (Sub-)Millennial-Scale Cooling?, Madeleine L. Vickers, Mads E. Jelby, Carlette N. Blok, Gregory D. Price, Rhodri M. Jerrett, Maria A. Jensen, Morgan T. Jones Mar 2025

Early Cretaceous Giant Glendonites: A Record Of (Sub-)Millennial-Scale Cooling?, Madeleine L. Vickers, Mads E. Jelby, Carlette N. Blok, Gregory D. Price, Rhodri M. Jerrett, Maria A. Jensen, Morgan T. Jones

School of Geography, Earth and Environmental Sciences

The Lower Cretaceous succession in Svalbard contains numerous glendonites, pseudomorphs after the cold-water carbonate mineral ikaite, which have been used in conjunction with other evidence to argue for episodic global cooling punctuating the greenhouse climates of the Early Cretaceous. Recent fieldwork in central Spitsbergen has recovered giant bladed glendonites of up to half a metre long, the largest ever recorded in a Lower Cretaceous site, and comparable in size to outlier glendonites found in similar-aged strata of the Sverdrup Basin in Arctic Canada. Unlike the rosette to pineapple-like morphologies seen in some of the largest Canadian Arctic specimens, the new …


Unraveling Algerian Bat Coronaviruses: From Initial Detection To Genome Recovery And Co-Infection Discovery, Safia Zeghbib, Zsófia Tauber, Tamás Görföl, Karimane Malek Zeghbib, Mourad Ahmim, Gábor Kemenesi Mar 2025

Unraveling Algerian Bat Coronaviruses: From Initial Detection To Genome Recovery And Co-Infection Discovery, Safia Zeghbib, Zsófia Tauber, Tamás Görföl, Karimane Malek Zeghbib, Mourad Ahmim, Gábor Kemenesi

School of Biomedical Sciences

IntroductionBats, known as main reservoirs for coronaviruses such as SARS-CoV and SARS-CoV-2, carry these viruses asymptomatically thanks to their unique immune systems. These viruses can spill over to humans through direct contact or intermediate hosts, as observed in the cases of SARS and COVID-19. Despite the significant public health implications, research on bat-related viral zoonoses remains inadequate in Algeria due to insufficient surveillance and funding. Additionally, the ecological diversity of Algerian bats is still largely unexplored, resulting in knowledge gaps. Therefore, investigating bat coronaviruses within the One Health framework in Algeria provides a holistic approach to understanding and mitigating the …


The Feasibility Of Ambulatory Heart Rate Variability Monitoring In Non‐Suicidal Self‐Injury, Rohit Shankar Mar 2025

The Feasibility Of Ambulatory Heart Rate Variability Monitoring In Non‐Suicidal Self‐Injury, Rohit Shankar

Peninsula Medical School

The polyvagal theory proposes that the autonomic nervous system influences affective systems and top-down emotional regulation.Vagal tone, as indexed by heart rate variability (HRV), is a measure of emotion regulation capacity. It is possible that non-suicidalself-injury (NSSI) occurs at times of low vagal tone and that NSSI may increase it. Little is known about the feasibility of collectingambulatory HRV data in the context of NSSI. This prospective observational study examined the feasibility of ambulatory HRVmonitoring during NSSI. Ten participants wore a chest-based heart rate monitor and used a diary app for 1 week. Baselinecharacteristics were collected. Heart rate monitoring duration, …


Microplastics And Nanoplastics In Tea: Sources, Characteristics And Potential Impacts, Neamatollah Jaafarzadeh Haghighi Fard, Faezeh Jahedi, Andrew Turner Feb 2025

Microplastics And Nanoplastics In Tea: Sources, Characteristics And Potential Impacts, Neamatollah Jaafarzadeh Haghighi Fard, Faezeh Jahedi, Andrew Turner

School of Geography, Earth and Environmental Sciences

Recent scientific studies have raised concerns about the presence and potential impacts of microplastics and nanoplastics (MNPs) in tea-based drinks. This review critically examines publications relating to MNPs in tea, with focus on the type of sample involved, methods and techniques employed to isolate and identify MNPs, and the main qualitative and quantitative findings. Sources of MNPs in tea include production water, plastic packaging and contaminated tea leaves but the most important source is teabags when steeped in boiling water. Here, more than 109 MNPs have been reported to be released per plastic teabag. However, significant quantities of MNPs …


Iegenes: A Machine Learning Method For Selecting Differentially Expressed Genes In Cancer Studies, Xiao-Lei Xia, Shang-Ming Zhou, Yunguang Liu, Na Lin, Ian Overton Feb 2025

Iegenes: A Machine Learning Method For Selecting Differentially Expressed Genes In Cancer Studies, Xiao-Lei Xia, Shang-Ming Zhou, Yunguang Liu, Na Lin, Ian Overton

School of Nursing and Midwifery

Gene selection is crucial for cancer classification using microarray data. In the interests of improvingcancer classification accuracy, in this paper, we developed a new wrapper method called ieGENES for geneselection. First we proposed a parsimonious kernel machine regularization (PKMR) model by usingridge regularization in kernel machine driven classification to tackle multi-collinearity for the sake of stableestimates in high-dimensional settings. Then the ieGENES algorithm was developed to optimally identifyrelevant genes while iteratively eliminating redundant ones based on leave-one-out cross-validation accuracy.In particular, we developed a new methodology to optimally update model parameters upon gene removal.The ieGENES algorithm was evaluated on six cancer …


For A Decolonial Approach To Game Design Methods Beyond Representation, Rafael Arrivabene Feb 2025

For A Decolonial Approach To Game Design Methods Beyond Representation, Rafael Arrivabene

School of Art, Design and Architecture

This article draws attention to game design methods in decolonialist studies. As the importance of systematization in game design starts to become apparent, there is an opportunity to challenge the normalization of values, tropes, and power fantasies that have shaped the industry over the years. The article discusses the ways in which colonialist values permeate recurrent elements of game design, contrasting it with characteristics found in pre-colonial games and how they can be related to indigenous perspectives, which usually do not fit capitalist premises.


Many-Objective Optimisation Of Offshore Wind Farms, Pawel L. Manikowski, Matthew J. Craven, David J. Walker Feb 2025

Many-Objective Optimisation Of Offshore Wind Farms, Pawel L. Manikowski, Matthew J. Craven, David J. Walker

School of Engineering, Computing and Mathematics

The design of offshore wind farms is computationally challenging, requiring the simultaneous optimisation of many conflicting objectives. Solving this problem is of paramount importance if society is to meet ambitious net zero goals. The problem is solved by identifying an optimal arrangement of individual turbines such that all objectives are optimised. However, a single solution does not exist due to the inherent conflict between objectives, and a set of solutions must be identified. As well as the challenge in generating optimal solution sets, there exists a decision support task if the solutions are to be effectively presented to a decision …


From Privacy Litigation To Privacy Restoration: How To Manage The Questions Of How, When, And Whether. Case Note: Tr V. Land Hessen (Case C-768/21), Camilla Della Giustina Feb 2025

From Privacy Litigation To Privacy Restoration: How To Manage The Questions Of How, When, And Whether. Case Note: Tr V. Land Hessen (Case C-768/21), Camilla Della Giustina

Plymouth Business School

The highest judicial body has recently hit the headlines. In TR v. Land Hessen, the Court of Justice of the EuropeanUnion (CJEU) has clarified the obligations incumbent on a supervisory authority pursuant to the General Data Protection Regulation (GDPR). The CJEU highlights that supervisory authorities are not obliged to exercise ‘corrective’ powers if not necessary to remedy the breach. It clarifies that under the GDPR, supervisory authorities have discretion in addressing the shortcomings of a supervised entity but must ensure compliance with a higher level of data protection.


Better Generalization Through Distraction? Concurrent Load Reduces The Size Of The Inverse Base-Rate Effect, Lenard Dome, Andy J. Wills Feb 2025

Better Generalization Through Distraction? Concurrent Load Reduces The Size Of The Inverse Base-Rate Effect, Lenard Dome, Andy J. Wills

School of Psychology

The inverse base-rate effect (IBRE) is an irrational phenomenon in predictive learning. It occurs when people try to generalize what they have experienced to novel and ambiguous events. This irrational generalization manifests as a preference for rare, unlikely outcomes in the face of ambiguity. At least two formal mathematical models of this irrational preference (EXIT, NNRAS) lead to a counter-intuitive prediction: the effect reduces under concurrent load. We tested this prediction across two experiments (N1 = 72, Mage = 20.12; N2 = 160, Mage = 20.88). We confirm the prediction, but only when participants were under an obvious time constraint. …


“The Future”: Interpretative Phenomenological Analysis Of General Practitioners' Experiences Of Co‐Employed Clinical Psychologists In Journal Of General And Family Medicine, Katie Monnickendam, Pete Keohane, Rebecca Magill Feb 2025

“The Future”: Interpretative Phenomenological Analysis Of General Practitioners' Experiences Of Co‐Employed Clinical Psychologists In Journal Of General And Family Medicine, Katie Monnickendam, Pete Keohane, Rebecca Magill

School of Psychology

BackgroundGeneral practice is overwhelmed and understaffed. New models and modalities must be considered from the front door of healthcare. Like general practitioners (GPs), clinical psychologists are qualified to work across the age range and transdiagnostically.AimTo explore GPs' understanding of the role of a clinical psychologist and to examine what is helpful and unhelpful for GPs about working alongside a clinical psychologist within general practice.Design and SettingThis research took place within a primary care general practice in the United Kingdom.MethodSeven qualified GPs were recruited as participants using a purposive sampling method. Interpretative phenomenological analysis was used to analyze participant's experiences of …


Australian And Uk Perspectives On Social Prescribing Implementation Research: Theory, Measurement, Resourcing And Discovery To Ensure Health Equity, Genevieve A. Dingle, Christina Aggar, Nikita Arslanovski, Thomas Astell-Burt, J. R. Baker, Ruthanne Baxter, Michelle Bissett, Mhairi Bowe, Eric Brymer, Alexandra Burton, Richard Byng, Julian Elston, Daisy Fancourt, Xiaoqi Feng, Emmanuel Fino, Rosanne Freak-Poli, Lydia Harkin, Daniel Hayes, Emma Hazeldine, Blerina Kellezi, Niamh Mcnamara, Leah Sharman, Clifford Stevenson, Juliet Wakefield, Katey Warran, Leanne Wells, Laura Wright, Yvonne Zurynski, Kerryn Husk Feb 2025

Australian And Uk Perspectives On Social Prescribing Implementation Research: Theory, Measurement, Resourcing And Discovery To Ensure Health Equity, Genevieve A. Dingle, Christina Aggar, Nikita Arslanovski, Thomas Astell-Burt, J. R. Baker, Ruthanne Baxter, Michelle Bissett, Mhairi Bowe, Eric Brymer, Alexandra Burton, Richard Byng, Julian Elston, Daisy Fancourt, Xiaoqi Feng, Emmanuel Fino, Rosanne Freak-Poli, Lydia Harkin, Daniel Hayes, Emma Hazeldine, Blerina Kellezi, Niamh Mcnamara, Leah Sharman, Clifford Stevenson, Juliet Wakefield, Katey Warran, Leanne Wells, Laura Wright, Yvonne Zurynski, Kerryn Husk

Peninsula Medical School

There has been a rapid increase in the delivery of social prescribing globally in recent years. However, a lack of theoretical framework, the diversity of social prescribing interventions and outcome measures, a lack of ongoing resources to provide services equitably and a lack of coordinated research agenda make it challenging for practitioners to know how best to put social prescribing into practice. This paper summarises perspectives from 29 UK and Australian authors and sets a course for future social prescribing implementation in four key areas: theory, measurement, resourcing and equity, and discovery (big questions on the research agenda). Eight recommendations …


The Effects Of Major Abdominal Surgery On Skeletal Muscle Mitochondrial Respiration In Relation To Systemic Redox Status And Cardiopulmonary Fitness, Jia L. Stevens, Daniel Martin, Helen Mckenna, Magdalena Minnion, Andrew Murray, Martin Feelisch Feb 2025

The Effects Of Major Abdominal Surgery On Skeletal Muscle Mitochondrial Respiration In Relation To Systemic Redox Status And Cardiopulmonary Fitness, Jia L. Stevens, Daniel Martin, Helen Mckenna, Magdalena Minnion, Andrew Murray, Martin Feelisch

Peninsula Medical School

More complex surgeries are being performed in increasingly sicker patients, resulting in a greater burden of postoperative morbidity. Delineating the metabolic and bioenergetic changes that occur in response to surgical stress may further our understanding about how humans respond to injury and aid the identification of resilient and frail phenotypes. Skeletal muscle biopsies were taken from patients undergoing hepato-pancreatico-biliary surgery at the beginning and end of the procedure to measure mitochondrial respiration and thiol status. Blood samples were taken at the same timepoints to measure markers of inflammation and systemic redox state. A sub-group of patients underwent cardiopulmonary exercise testing …


Multiphase Modelling Of Electrical Conductivity Of Concrete With Conductive Inclusions, Zaiwei Li, Feiyu Shi, Long Yuan Li Feb 2025

Multiphase Modelling Of Electrical Conductivity Of Concrete With Conductive Inclusions, Zaiwei Li, Feiyu Shi, Long Yuan Li

School of Engineering, Computing and Mathematics

Electrical conductivity (EC) of concrete can be effectively improved by incorporating conductive materials such as carbon nanotubes in the mix design. However, mechanism for the EC enhancement to which the addition of conductive materials contributes has not yet been well understood. Besides, either sand or coarse aggregate in concrete also affects the EC of concrete, which complicates understanding of the mechanism. This paper presents a multiphase analytical model to investigate the effect of constituents on the effective EC of concrete. This multi-phase model was developed based on Maxwell model which was modified in this research to consider the effects of …


Post-Traumatic Growth And Influencing Factors Of Parents With Children With Duchenne Muscular Dystrophy: A Cross-Sectional Survey Study, Li Xu, Meili Liu, Yuewei Chen, Liwen Wu, Siyi Gan, Jianhui Xie, Jos M. Latour Feb 2025

Post-Traumatic Growth And Influencing Factors Of Parents With Children With Duchenne Muscular Dystrophy: A Cross-Sectional Survey Study, Li Xu, Meili Liu, Yuewei Chen, Liwen Wu, Siyi Gan, Jianhui Xie, Jos M. Latour

School of Nursing and Midwifery

Background: The aim of the study was to identify the post-traumatic growth status and influencing factors of parents with children with Duchenne muscular dystrophy (DMD). Methods: We adopted a cross-section survey study. Between February and December 2022, 181 parents responded to the survey including a participants’ characteristics section, post-traumatic growth assessment scale, caregiver burden scale, and social support assessment scale. Multiple linear regression analysis was used to investigate influencing factors of post-traumatic growth. Results: The mean score of post-traumatic growth of parents was 56.66 (SD ± 18.67). Post-traumatic growth was positively correlated with social support (r = 0.452, P < 0.01) and negatively correlated with care burden (r = -0.207, P < 0.01). Multiple linear regression showed that the child’s age, course of disease, self-care ability, parent’s working condition, residence, education, number of children, and health status were the main influencing factors for the post-traumatic growth of parents (P < 0.001). Conclusion: The post-traumatic growth of parents with children with DMD was at a moderate level. Healthcare professionals should pay attention to the psychological state of parents with children with this rare disease and promote post-traumatic growth through psychological mindfulness interventions, strengthening family and social support, and providing care knowledge and skills.


Gender And Sexuality: Lgbtq+ Youth Experiences, Lauren B. Mcinroy, Kathryn Macapagal, Oliver Beer, Claire Coyne Feb 2025

Gender And Sexuality: Lgbtq+ Youth Experiences, Lauren B. Mcinroy, Kathryn Macapagal, Oliver Beer, Claire Coyne

School of Health Professions

Internet-enabled information and communication technologies (ICTs) pose simultaneous risks and opportunities for contemporary lesbian, gay, bisexual, transgender, queer, or otherwise sexual and/or gender diverse (LGBTQ+) adolescents and young adults—a population who may be particularly active users of ICTs. This chapter provides a brief overview of LGBTQ+ youths’ lived experiences and barriers to care, followed by a review of extant knowledge regarding the ICT experiences of this population with a particular focus on the context of the United States. Significant gaps in knowledge regarding LGBTQ+ youths’ engagement with ICTs persist and proposed areas of inquiry for future research are provided. As …


Future Climate-Driven Habitat Loss And Range Shift Of The Critically Endangered Whitefin Swellshark (Cephaloscyllium Albipinnum), Kerry Brown, Robert Puschendorf Feb 2025

Future Climate-Driven Habitat Loss And Range Shift Of The Critically Endangered Whitefin Swellshark (Cephaloscyllium Albipinnum), Kerry Brown, Robert Puschendorf

School of Biological and Marine Sciences

Climate change is driving many species to shift their geographical ranges poleward to maintain their environmental niche. However, for endemic species with restricted ranges, like the Critically Endangered whitefin swellshark (Cephaloscyllium albipinnum), endemic to southeastern Australia, such dispersal may be limited. Nevertheless, there is a poor understanding of how C. albipinnum might spatially adjust its distribution in response to climate change or whether suitable refugia exist for this species in the future. Therefore, to address this gap, this study utilised maximum entropy (MaxEnt) modelling to determine the potential distribution of suitable habitat for C. albipinnum under present-day (2010–2020) climate conditions …


Coastal And Rural Digital Exclusion - The Case For Voice Ai, Rory Baxter, Oksana Hagen, Amir Aly, Ray Jones, Katharine Willis Feb 2025

Coastal And Rural Digital Exclusion - The Case For Voice Ai, Rory Baxter, Oksana Hagen, Amir Aly, Ray Jones, Katharine Willis

School of Nursing and Midwifery

The adoption of digital platforms for health and social resources disadvantages vulnerable populations, including older adults and those living in remote or deprived areas. This could be remediated using voice-based conversational AI (Voice AI) systems delivered via landline phone, bypassing the requirement for digital device access or digital skills. British rural and coastal regions often have poorer digital infrastructure and pockets of deprivation, and consequently higher levels of digital exclusion. This study explores digital exclusion in Southwest England and the suitability of Voice AI systems for supporting digital inclusion. Seventeen participants aged 50 years or over were interviewed by telephone …


Enhancing Diagnostic Accuracy Of Drug-Resistant Tuberculosis On Chest X-Rays Using Data-Efficient Image Transformers, Joan Mnyambo, Amir Aly, Shang-Ming Zhou, Yinghui Wei, Stephen Mullin, Emmanuel Ifeachor Feb 2025

Enhancing Diagnostic Accuracy Of Drug-Resistant Tuberculosis On Chest X-Rays Using Data-Efficient Image Transformers, Joan Mnyambo, Amir Aly, Shang-Ming Zhou, Yinghui Wei, Stephen Mullin, Emmanuel Ifeachor

School of Engineering, Computing and Mathematics

Tuberculosis is an infectious disease with increasing fatalities around the world. The diagnosis of the diseaseis a major challenge to its control and management due to the lack of adequate diagnostic tools, contributingsignificantly to the prevalence of drug-resistant tuberculosis. Convolutional Neural Network (CNN) modelshave recently been developed to detect drug-resistant tuberculosis by analyzing chest radiograph images fromthe TB portal, but the classification results are low. This is because CNNs struggle to capture complex globaland overlapping features in medical imaging, such as chest radiographs of drug-resistant tuberculosis. Incontrast, transformers excel in these areas by utilizing self-attention mechanisms that detect inherent subtle …


Reward Responses To Vicarious Feeding Depend On Body Mass Index, Lili Järvinen, Severi Santavirta, Vesa Putkinen, Henry K Karlsson, Kerttu Seppälä, Lihua Sun, Matthew Hudson, Jussi Hirvonen, Pirjo Nuutila, Lauri Nummenmaa Feb 2025

Reward Responses To Vicarious Feeding Depend On Body Mass Index, Lili Järvinen, Severi Santavirta, Vesa Putkinen, Henry K Karlsson, Kerttu Seppälä, Lihua Sun, Matthew Hudson, Jussi Hirvonen, Pirjo Nuutila, Lauri Nummenmaa

School of Psychology

Eating is inherently social for humans. Yet, most neuroimaging studies of appetite and food-induced reward have focused on studying brain responses to food intake or viewing pictures of food alone. We used functional magnetic resonance imaging (fMRI) to measure haemodynamic responses to “vicarious” feeding. The subjects (n = 97) viewed series of short videos representing naturalistic episodes of social eating intermixed with videos without feeding/appetite-related content. Viewing the vicarious feeding (versus control) videos activated motor and premotor cortices, thalamus, and dorsolateral prefrontal cortices, consistent with somatomotor and affective engagement. Responses to the feeding videos were negatively correlated with the participants’ …


Inhale Wp3, A Multicentre, Open-Label, Pragmatic Randomised Controlled Trial Assessing The Impact Of Rapid, Icu-Based, Syndromic Pcr, Versus Standard-Of-Care On Antibiotic Stewardship And Clinical Outcomes In Hospital-Acquired And Ventilator-Associated Pneumonia, Inhale Wp3 Study Group And Committees, Virve I Enne, Susan Stirling, Julie A Barber, Juliet High, Charlotte Russell, David Brealey, Zaneeta Dhesi, Antony Colles, Suveer Singh, Robert Parker, Mark Peters, Benny P Cherian, Peter Riley, Matthew Dryden, Ruan Simpson, Nehal Patel, Jane Cassidy, Daniel Martin, Ingeborg D Welters, Valerie Page, Hala Kandil, Eleanor Tudtud, David Turner, Robert Horne, Justin O'Grady, Ann Marie Swart, David M Livermore, Vanya Gant Feb 2025

Inhale Wp3, A Multicentre, Open-Label, Pragmatic Randomised Controlled Trial Assessing The Impact Of Rapid, Icu-Based, Syndromic Pcr, Versus Standard-Of-Care On Antibiotic Stewardship And Clinical Outcomes In Hospital-Acquired And Ventilator-Associated Pneumonia, Inhale Wp3 Study Group And Committees, Virve I Enne, Susan Stirling, Julie A Barber, Juliet High, Charlotte Russell, David Brealey, Zaneeta Dhesi, Antony Colles, Suveer Singh, Robert Parker, Mark Peters, Benny P Cherian, Peter Riley, Matthew Dryden, Ruan Simpson, Nehal Patel, Jane Cassidy, Daniel Martin, Ingeborg D Welters, Valerie Page, Hala Kandil, Eleanor Tudtud, David Turner, Robert Horne, Justin O'Grady, Ann Marie Swart, David M Livermore, Vanya Gant

Peninsula Medical School

PURPOSE: INHALE investigated the impact of seeking pathogens by PCR on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia (HAP and VAP).

METHODS: This pragmatic multicentre, open-label RCT enrolled adults and children with suspected HAP and VAP at 14 ICUs. Patients were randomly allocated to standard of care, or rapid in-ICU syndromic PCR coupled with optional prescribing guidance. Co-primary outcomes were superiority in antibiotic stewardship at 24 h and non-inferiority in clinical cure of pneumonia 14 days post-randomisation. Secondary outcomes included mortality, ICU length of stay and evolution of clinical scores.

RESULTS: 554 eligible patients were recruited from …


Physiotherapists’ And Occupational Therapists’ Experiences Of Working With People With Atypical Parkinson’S Conditions, Kate Blandford, Tanja Križaj Feb 2025

Physiotherapists’ And Occupational Therapists’ Experiences Of Working With People With Atypical Parkinson’S Conditions, Kate Blandford, Tanja Križaj

School of Health Professions

Purpose: The purpose of this study was to gain deeper understanding of the experiences of occupational therapists and physiotherapists, working with those with atypical Parkinson’s conditions, within the UK. A literature review identified that research into these roles is limited and unrepresentative. Materials and methods: A qualitative approach, informed by hermeneutic phenomenology was used to guide the study design. Semi-structured, online interviews, focussed on therapists’ experiences of success and challenge, were completed with six physiotherapists, and three occupational therapists, experienced in working within this area of practice. The interviews were recorded and transcribed verbatim and were analysed using Braun and …


Techno-Economic Analysis For Floating Offshore Wind And Offshore Green Hydrogen, David Pegler, Deborah Greaves, Robert Rawlinson-Smith, Simone Michele, Daniel Conley, James Benhin Feb 2025

Techno-Economic Analysis For Floating Offshore Wind And Offshore Green Hydrogen, David Pegler, Deborah Greaves, Robert Rawlinson-Smith, Simone Michele, Daniel Conley, James Benhin

School of Engineering, Computing and Mathematics

This paper describes a techno-economic model for exploiting the Celtic Sea wind resource through direct productionof hydrogen offshore. The model conceives a modular approach with eight 510 MW floating windfarms,each with an electrolyser system and export compressor mounted on a jacket. The model ensures an uninterruptedhydrogen supply to an industrial cluster (16.4 te.H2/h) by incorporating salt cavern hydrogen storage.During periods of no power generation, baseload power is provided from hydrogen fuel cells. The base-casemodel with a Discount Rate of 6% returned an Levelised Cost of Hydrogen (LCoH) of £7.25 per kg of hydrogen in2023. The LCoH shows strong sensitivity to …


Exploring Health Conditions: Learning Beyond The Textbook, Casper Jonker, Wendy Smith, Vehid Salih Feb 2025

Exploring Health Conditions: Learning Beyond The Textbook, Casper Jonker, Wendy Smith, Vehid Salih

Peninsula Dental School

No abstract provided.


Social Comfort And Attractiveness Perception: Impact Of Prosthetics, Physical Disability And Comfort Distance On Interpersonal Interactions, Farid Pazhoohi, Samantha Wing, Alan Kingstone Feb 2025

Social Comfort And Attractiveness Perception: Impact Of Prosthetics, Physical Disability And Comfort Distance On Interpersonal Interactions, Farid Pazhoohi, Samantha Wing, Alan Kingstone

School of Psychology

Derived from the disease-avoidance model is the hypothesis that people may direct negative cognitive and behavioural responses towards individuals with physical disfiguring conditions, including physical disabilities. According to the behavioral immune system, physical disability—a non-contagious physical disfigurement—may falsely activate cognitive disease-avoidance processes, resulting in prejudicial or negative responses toward individuals with physical disabilities. For the first time this hypothesis is put to the test by investigating whether ratings of attractiveness and comfort for a social interaction vary systematically with physical disability (Studies 1 and 2). In addition, we tested whether these ratings were associated with individual differences in pathogen disgust …


Young-Onset Diabetes Poses A Greater Risk Of End-Stage Renal Disease (Esrd) Than Cardiovascular Disease And Stroke: A Retrospective Cohort Study Of Uk Biobank, Debasish Kar, Richard Byng, Stuart Spicer, Nicolas Farina, Jonathan Pinkney, Soon Song, Bedowra Zabeen, Shubharthi Kar, Jitendra Jonnagaddala, Siaw-Teng Liaw, Aya El-Wazir, Mintu Nath, Moein Ab Khan, Aziz Sheikh, Simon De Lusignan Feb 2025

Young-Onset Diabetes Poses A Greater Risk Of End-Stage Renal Disease (Esrd) Than Cardiovascular Disease And Stroke: A Retrospective Cohort Study Of Uk Biobank, Debasish Kar, Richard Byng, Stuart Spicer, Nicolas Farina, Jonathan Pinkney, Soon Song, Bedowra Zabeen, Shubharthi Kar, Jitendra Jonnagaddala, Siaw-Teng Liaw, Aya El-Wazir, Mintu Nath, Moein Ab Khan, Aziz Sheikh, Simon De Lusignan

Peninsula Medical School

BackgroundIn the last three decades, in people with diabetes, while the mortality and morbidity due to cardiovascular disease (CVD) and stroke have declined, the incidence of end-stage renal disease (ESRD) has crept up. The precise cause for this shift is unknown. Intriguingly, during the same period, the incidence of diabetes in younger people has almost tripled worldwide. This study examines whether young-onset diabetes is a greater risk for ESRD compared to CVD and stroke.MethodsWe conducted this retrospective cohort study using data from volunteers (n = 502,408) aged 40–69 years recruited in UK Biobank between 2006 and 2010. The exposure variable …


Implementing Identity-Based Signature Schemes For Secure Data Transfer In Cloud Computing Environments, Paul Osinuga, Ji-Jian Chin, Terry Shue Chien Lau Feb 2025

Implementing Identity-Based Signature Schemes For Secure Data Transfer In Cloud Computing Environments, Paul Osinuga, Ji-Jian Chin, Terry Shue Chien Lau

School of Engineering, Computing and Mathematics

In this paper, we present the implementation of the Cha-Cheon Identity-Based Signature (IBS) scheme to enhance secure data transfer in cloud computing environments. Cloud computingrely on traditional Public Key Infrastructure (PKI) systems, which is burdened by certificate management infrastructure. The primary focus of this research to simplify key and certificate management by leveraging identity-based elliptic curve cryptography (ECC) within the Cha-Cheon IBS framework. We show that the proposed IBS solution integrates seamlessly with Amazon Web Services (AWS), utilizing services like S3 for secure data storage and KMSfor key management. By applying ECC, the Cha-Cheon scheme achieves efficient cryptographic operations with …