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Articles 5071 - 5100 of 6794
Full-Text Articles in Entire DC Network
Blobs In Tartan Colours: Margaret Tait's Painted Eightsome, K Parker
Blobs In Tartan Colours: Margaret Tait's Painted Eightsome, K Parker
School of Art, Design and Architecture
This essay explores the interplay of Julia Kristeva's concepts of semiotic and symbolic in the Orcadian film-poet Margaret Tait's direct animation film Painted Eightsome, in which the music of a Scottish reel is combined with animated artwork painted frame-by-frame onto clear 35mm film. As a creative artist, Tait used a range of forms. She wrote prose and poetry, and made short films, usually shooting on 16mm with her clockwork Bolex camera. In her cinematic work she explored an array of highly experimental techniques, including painting and scratching on the film surface, from the beginning of her filmmaking career in Italy …
Determination Of Dissolved Iron In Seawater: A Historical Review, Paul J. Worsfold, Maeve C. Lohan, Simon J. Ussher, Andrew R. Bowie
Determination Of Dissolved Iron In Seawater: A Historical Review, Paul J. Worsfold, Maeve C. Lohan, Simon J. Ussher, Andrew R. Bowie
School of Geography, Earth and Environmental Sciences
This paper overviews the evolution of suitable analytical approaches for the determination of dissolved iron in seawater. The focus is on sampling and sample treatment, detection methods and quality assurance of the data. Iron is a vital trace element for the growth of marine organisms and is the limiting micronutrient for primary production in many parts of the world's oceans. The concentration of dissolved iron in seawater therefore influences the past and present day global carbon cycle and consequently Earth's climate. Hence it is important to understand the marine biogeochemistry of iron and quantify the spatial and temporal distribution of …
Horizontal Dispersion In Shelf Seas: High Resolution Modelling As An Aid To Sparse Sampling, Nataliya Stashchuk, Vasiliy Vlasenko, Mark E. Inall, Dmitry Aleynik
Horizontal Dispersion In Shelf Seas: High Resolution Modelling As An Aid To Sparse Sampling, Nataliya Stashchuk, Vasiliy Vlasenko, Mark E. Inall, Dmitry Aleynik
School of Biological and Marine Sciences
The ability of a hydrodynamic model to reproduce the results of a dye release experiment conducted in a wide shelf sea environment was investigated with the help of the Massachusetts Institute of Technology general circulation model (MITgcm). In the field experiment a fluorescent tracer, Rhodamine WT, was injected into the seasonal pycnocline, and its evolution was tracked for two days using a towed undulating vehicle equipped with a fluorometer and a CTD. With a 50. m horizontal resolution grid, and with three different forcings initialized in the model (viz: tides, stationary current, and wind stress on the free surface), it …
Gaze Stabilization For Humanoid Robots: A Comprehensive Framework, A Roncone, U Pattacini, G Metta, L Natale
Gaze Stabilization For Humanoid Robots: A Comprehensive Framework, A Roncone, U Pattacini, G Metta, L Natale
School of Engineering, Computing and Mathematics
Gaze stabilization is an important requisite for humanoid robots. Previous work on this topic has focused on the integration of inertial and visual information. Little attention has been given to a third component, which is the knowledge that the robot has about its own movement. In this work we propose a comprehensive framework for gaze stabilization in a humanoid robot. We focus on the problem of compensating for disturbances induced in the cameras due to self-generated movements of the robot. In this work we employ two separate signals for stabilization: (1) an anticipatory term obtained from the velocity commands sent …
Germination And Persistence Of Bacillus Anthracis And Bacillus Thuringiensis In Soil Microcosms, Ah Bishop
Germination And Persistence Of Bacillus Anthracis And Bacillus Thuringiensis In Soil Microcosms, Ah Bishop
School of Biological and Marine Sciences
AIMS: Decontaminating large, outdoor spaces of Bacillus anthracis spores presents significant problems, particularly in soil. Proof was sought that the addition of germinant chemicals could cause spores of B. anthracis and Bacillus thuringiensis, a commonly used simulant of the threat agent, to convert to the less resistant vegetative form in a microcosm. METHODS AND RESULTS: Nonsterile plant/soil microcosms were inoculated with spores of B. thuringiensis and two nonpathogenic strains of B. anthracis. A combination of L-alanine (100 mmol l(-1)) and inosine (10 mmol l(-1)) resulted in a 6 log decrease in spore numbers in both strains of B. anthracis over …
Fabrication And Evaluation Of A Micro(Bio)Sensor Array Chip For Multiple Parallel Measurements Of Important Cell Biomarkers, Roy M. Pemberton, Timothy Cox, Rachel Tuffin, Guido A. Drago, John Griffiths, Robin Pittson, Graham Johnson, Jinsheng Xu, Ian C. Sage, Rhodri Davies, Simon K. Jackson, Gerry Kenna, Richard Luxton, John P. Hart
Fabrication And Evaluation Of A Micro(Bio)Sensor Array Chip For Multiple Parallel Measurements Of Important Cell Biomarkers, Roy M. Pemberton, Timothy Cox, Rachel Tuffin, Guido A. Drago, John Griffiths, Robin Pittson, Graham Johnson, Jinsheng Xu, Ian C. Sage, Rhodri Davies, Simon K. Jackson, Gerry Kenna, Richard Luxton, John P. Hart
School of Biomedical Sciences
This report describes the design and development of an integrated electrochemical cell culture monitoring system, based on enzyme-biosensors and chemical sensors, for monitoring indicators of mammalian cell metabolic status. MEMS technology was used to fabricate a microwell-format silicon platform including a thermometer, onto which chemical sensors (pH, O2) and screen-printed biosensors (glucose, lactate), were grafted/deposited. Microwells were formed over the fabricated sensors to give 5-well sensor strips which were interfaced with a multipotentiostat via a bespoke connector box interface. The operation of each sensor/biosensor type was examined individually, and examples of operating devices in five microwells in parallel, …
Human Cytomegalovirus-Encoded Pul7 Is A Novel Ceacam1-Like Molecule Responsible For Promotion Of Angiogenesis., Jason D. Macmaniman, Andrew Meuser, Sara Botto, Patricia P. Smith, Fenyong Liu, Michael A. Jarvis, Jay A. Nelson, Patrizia Caposio
Human Cytomegalovirus-Encoded Pul7 Is A Novel Ceacam1-Like Molecule Responsible For Promotion Of Angiogenesis., Jason D. Macmaniman, Andrew Meuser, Sara Botto, Patricia P. Smith, Fenyong Liu, Michael A. Jarvis, Jay A. Nelson, Patrizia Caposio
School of Biomedical Sciences
UNLABELLED: Persistent human cytomegalovirus (HCMV) infection has been linked to several diseases, including atherosclerosis, transplant vascular sclerosis (TVS), restenosis, and glioblastoma. We have previously shown that factors secreted from HCMV-infected cells induce angiogenesis and that this process is due, at least in part, to increased secretion of interleukin-6 (IL-6). In order to identify the HCMV gene(s) responsible for angiogenesis promotion, we constructed a large panel of replication-competent HCMV recombinants. One HCMV recombinant deleted for UL1 to UL10 was unable to induce secretion of factors necessary for angiogenesis. Fine mapping using additional HCMV recombinants identified UL7 as a viral gene required …
Elaborated Intrusion Theory: Explaining The Cognitive And Motivational Basis Of Desire., J May, J Andrade, Dillen L Van, D Kavanagh
Elaborated Intrusion Theory: Explaining The Cognitive And Motivational Basis Of Desire., J May, J Andrade, Dillen L Van, D Kavanagh
School of Psychology
No abstract provided.
Fermentation And Antimicrobial Characteristics Of Lactobacillus Plantarum And Candida Tropicalis From Nigerian Fermented Maize (Akamu), Patience C. Obinna-Echem, Victor Kuri, Jane Beal
Fermentation And Antimicrobial Characteristics Of Lactobacillus Plantarum And Candida Tropicalis From Nigerian Fermented Maize (Akamu), Patience C. Obinna-Echem, Victor Kuri, Jane Beal
School of Biological and Marine Sciences
This study investigated the ability of Lactobacillus plantarum strains (NGL5 and NGL7) and Candida tropicalis (NGY1) previously identified from akamu-a Nigerian fermented maize food with probiotic L. plantarum LpTx and Saccharomyces boulardii SB20 to ferment ground maize slurries based on pH, acidity, microbial biomass, levels of sugars and organic acids, and their antimicrobial activity against Salmonella enterica serovar Enteritidis NCTC 5188, Escherichia coli NCTC 11560, Bacillus cereus NCIMB 11925, Staphylococcus aureus NCTC 3750 and Listeria monocytogenes NCTC 7973 using an agar spot assay. L. plantarum strains either as single or mixed starter cultures with the yeasts had growth rates ≥0.15 …
Artesunate Induces Necrotic Cell Death In Schwannoma Cells., R. W. Button, F. Lin, E. Ercolano, J. H. Vincent, B. Hu, C. O. Hanemann, S. Luo
Artesunate Induces Necrotic Cell Death In Schwannoma Cells., R. W. Button, F. Lin, E. Ercolano, J. H. Vincent, B. Hu, C. O. Hanemann, S. Luo
Peninsula Medical School
Established as a potent anti-malaria medicine, artemisinin-based drugs have been suggested to have anti-tumour activity in some cancers. Although the mechanism is poorly understood, it has been suggested that artemisinin induces apoptotic cell death. Here, we show that the artemisinin analogue artesunate (ART) effectively induces cell death in RT4 schwannoma cells and human primary schwannoma cells. Interestingly, our data indicate for first time that the cell death induced by ART is largely dependent on necroptosis. ART appears to inhibit autophagy, which may also contribute to the cell death. Our data in human schwannoma cells show that ART can be combined …
On The Dynamics Of The Adenylate Energy System: Homeorhesis Vs Homeostasis, La De, Im Fuente, Jm Cortés, E Valero, Et Al
On The Dynamics Of The Adenylate Energy System: Homeorhesis Vs Homeostasis, La De, Im Fuente, Jm Cortés, E Valero, Et Al
School of Biomedical Sciences
Biochemical energy is the fundamental element that maintains both the adequate turnover of the biomolecular structures and the functional metabolic viability of unicellular organisms. The levels of ATP, ADP and AMP reflect roughly the energetic status of the cell, and a precise ratio relating them was proposed by Atkinson as the adenylate energy charge (AEC). Under growth-phase conditions, cells maintain the AEC within narrow physiological values, despite extremely large fluctuations in the adenine nucleotides concentration. Intensive experimental studies have shown that these AEC values are preserved in a wide variety of organisms, both eukaryotes and prokaryotes. Here, to understand some …
Outcomes And Intentions In Children’S, Adolescents’, And Adults’ Second- And Third-Party Punishment Behavior, M Gummerum, Mt Chu
Outcomes And Intentions In Children’S, Adolescents’, And Adults’ Second- And Third-Party Punishment Behavior, M Gummerum, Mt Chu
School of Psychology
Theories of morality maintain that punishment supports the emergence and maintenance of moral behavior. This study investigated developmental differences in the role of outcomes and the violator's intentions in second-party punishment (where punishers are victims of a violation) and third-party punishment (where punishers are unaffected observers of a violation). Four hundred and forty-three adults and 8-, 12-, and 15-year-olds made choices in mini-ultimatum games and newly-developed mini-third-party punishment games, which involved actual incentives rather than hypothetical decisions. Adults integrated outcomes and intentions in their second- and third-party punishment, whereas 8-year-olds consistently based their punishment on the outcome of the violation. …
Fatty Acid Uptake And Lipid Storage Induced By Hif-1Α Contribute To Cell Growth And Survival After Hypoxia-Reoxygenation, K Bensaad, E Favaro, Ca Lewis, B Peck, Et Al
Fatty Acid Uptake And Lipid Storage Induced By Hif-1Α Contribute To Cell Growth And Survival After Hypoxia-Reoxygenation, K Bensaad, E Favaro, Ca Lewis, B Peck, Et Al
School of Biomedical Sciences
An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were induced by hypoxia in a hypoxia-inducible factor-1α (HIF-1α)-dependent manner. There was a significant lipid droplet (LD) accumulation in hypoxia that was time and O2 concentration dependent. Knockdown of endogenous expression of FABP3, FABP7, or Adipophilin (an essential LD structural component) significantly impaired LD formation under hypoxia. We showed that LD accumulation is due to FABP3/7-dependent fatty acid uptake while de novo fatty …
Bacterio-Plankton Transformation Of Diazepam And 2-Amino-5-Chlorobenzophenone In River Waters, Alan D. Tappin, J. Paul Loughnane, Alan J. Mccarthy, Mark F. Fitzsimons
Bacterio-Plankton Transformation Of Diazepam And 2-Amino-5-Chlorobenzophenone In River Waters, Alan D. Tappin, J. Paul Loughnane, Alan J. Mccarthy, Mark F. Fitzsimons
School of Geography, Earth and Environmental Sciences
Benzodiazepines are a large class of commonly-prescribed drugs used to treat a variety of clinical disorders. They have been shown to produce ecological effects at environmental concentrations, making understanding their fate in aquatic environments very important. In this study, uptake and biotransformations by riverine bacterio-plankton of the benzodiazepine, diazepam, and 2-amino-5-chlorobenzophenone, ACB (a photo-degradation product of diazepam and several other benzodiazepines), were investigated using batch microcosm incubations. These were conducted using water and bacterio-plankton populations from contrasting river catchments (Tamar and Mersey, UK), both in the presence and absence of a peptide, added as an alternative organic substrate. Incubations lasted …
From Medicine To Butterflies And Back Again, C Parmesan
From Medicine To Butterflies And Back Again, C Parmesan
School of Biological and Marine Sciences
My research focuses on the current impacts of climate change on wildlife, from field-based work on butterflies to synthetic analyses of global impacts on a broad range of species across terrestrial and marine biomes. I work actively with governmental agencies and NGOs to help develop conservation assessment and planning tools aimed at preserving biodiversity in the face of climate change.
The Elaborated Intrusion Theory Of Desire: A 10-Year Retrospective And Implications For Addiction Treatments, Jon May, David J. Kavanagh, Jackie Andrade
The Elaborated Intrusion Theory Of Desire: A 10-Year Retrospective And Implications For Addiction Treatments, Jon May, David J. Kavanagh, Jackie Andrade
School of Psychology
Ten years after the publication of Elaborated Intrusion (EI) Theory, there is now substantial research into its key predictions. The distinction between intrusive thoughts, which are driven by automatic processes, and their elaboration, involving controlled processing, is well established. Desires for both addictive substances and other desired targets are typically marked by imagery, especially when they are intense. Attention training strategies such as body scanning reduce intrusive thoughts, while concurrent tasks that introduce competing sensory information interfere with elaboration, especially if they compete for the same limited-capacity working memory resources. EI Theory has spawned new assessment instruments that are performing …
Multiple Metabolomics Of Uropathogenic E. Coli Reveal Different Information Content In Terms Of Metabolic Potential Compared To Virulence Factors., Haitham Alrabiah, Yun Xu, Nicholas J.W. Rattray, Andrew A. Vaughan, Tarek Gibreel, Ali Sayqal, Mathew Upton, J. William Allwood, Royston Goodacre
Multiple Metabolomics Of Uropathogenic E. Coli Reveal Different Information Content In Terms Of Metabolic Potential Compared To Virulence Factors., Haitham Alrabiah, Yun Xu, Nicholas J.W. Rattray, Andrew A. Vaughan, Tarek Gibreel, Ali Sayqal, Mathew Upton, J. William Allwood, Royston Goodacre
School of Biomedical Sciences
No single analytical method can cover the whole metabolome and the choice of which platform to use may inadvertently introduce chemical selectivity. In order to investigate this we analysed a collection of uropathogenic Escherichia coli. The selected strains had previously undergone extensive characterisation using classical microbiological methods for a variety of metabolic tests and virulence factors. These bacteria were analysed using Fourier transform infrared (FT-IR) spectroscopy; gas chromatography mass spectrometry (GC-MS) after derivatisation of polar non-volatile analytes; as well as reversed-phase liquid chromatography mass spectrometry in both positive (LC-MS(+ve)) and negative (LC-MS(-ve)) electrospray ionisation modes. A comparison of the discriminatory …
Thermal Niche Evolution And Geographical Range Expansion In A Species Complex Of Western Mediterranean Diving Beetles., Amparo Hidalgo-Galiana, David Sánchez-Fernández, David T. Bilton, Alexandra Cieslak, Ignacio Ribera
Thermal Niche Evolution And Geographical Range Expansion In A Species Complex Of Western Mediterranean Diving Beetles., Amparo Hidalgo-Galiana, David Sánchez-Fernández, David T. Bilton, Alexandra Cieslak, Ignacio Ribera
School of Biological and Marine Sciences
BACKGROUND: Species thermal requirements are one of the principal determinants of their ecology and biogeography, although our understanding of the interplay between these factors is limited by the paucity of integrative empirical studies. Here we use empirically collected thermal tolerance data in combination with molecular phylogenetics/phylogeography and ecological niche modelling to study the evolution of a clade of three western Mediterranean diving beetles, the Agabus brunneus complex. RESULTS: The preferred mitochondrial DNA topology recovered A. ramblae (North Africa, east Iberia and Balearic islands) as paraphyletic, with A. brunneus (widespread in the southwestern Mediterranean) and A. rufulus (Corsica and Sardinia) nested …
Expression Of Prta From Photorhabdus Luminescens In Bacillus Thuringiensis Enhances Mortality In Lepidopteran Larvae By Sub-Cutaneous But Not Oral Infection, Ah Bishop
School of Biological and Marine Sciences
The prtA gene from Photorhabdus luminescens encodes the virulence factor Protease A. When P. luminescens is injected into the hemocoel of insects by entomopathogenic nematodes, PrtA is a key component of pathogenicity thought to help degrade the immune system. The prtA gene was cloned and introduced on a plasmid into Bacillus thuringiensis. PrtA was shown to be actively expressed in vitro by cleavage of a specific Dabcyl-Edans heptapeptide substrate. There was no difference in the speed or level of mortality when spores and δ-endotoxins crystals of the transformed strain were fed to larvae of Pieris brassicae, as compared to the …
Modelling Storm Hydrodynamics On Gravel Beaches With Xbeach-G, R. T. Mccall, G. Masselink, T. G. Poate, J. A. Roelvink, L. P. Almeida, M. Davidson, P. E. Russell
Modelling Storm Hydrodynamics On Gravel Beaches With Xbeach-G, R. T. Mccall, G. Masselink, T. G. Poate, J. A. Roelvink, L. P. Almeida, M. Davidson, P. E. Russell
School of Biological and Marine Sciences
No abstract provided.
Adam10 Mediates Trastuzumab Resistance And Is Correlated With Survival In Her2 Positive Breast Cancer, K Feldinger, D Generali, G Kramer-Marek, M Gijsen, Et Al
Adam10 Mediates Trastuzumab Resistance And Is Correlated With Survival In Her2 Positive Breast Cancer, K Feldinger, D Generali, G Kramer-Marek, M Gijsen, Et Al
School of Biomedical Sciences
Trastuzumab prolongs survival in HER2 positive breast cancer patients. However, resistance remains a challenge. We have previously shown that ADAM17 plays a key role in maintaining HER2 phosphorylation during trastuzumab treatment. Beside ADAM17, ADAM10 is the other well characterized ADAM protease responsible for HER ligand shedding. Therefore, we studied the role of ADAM10 in relation to trastuzumab treatment and resistance in HER2 positive breast cancer. ADAM10 expression was assessed in HER2 positive breast cancer cell lines and xenograft mice treated with trastuzumab. Trastuzumab treatment increased ADAM10 levels in HER2 positive breast cancer cells (p ≤ 0.001 in BT474; p ≤ …
Extraction And Sensitive Detection Of Toxins A And B From The Human Pathogen Clostridium Difficile In 40 Seconds Using Microwave-Accelerated Metal-Enhanced Fluorescence, Lovleen Tina Joshi, Buddha L. Mali, Chris D. Geddes, Les Baillie
Extraction And Sensitive Detection Of Toxins A And B From The Human Pathogen Clostridium Difficile In 40 Seconds Using Microwave-Accelerated Metal-Enhanced Fluorescence, Lovleen Tina Joshi, Buddha L. Mali, Chris D. Geddes, Les Baillie
Peninsula Dental School
No abstract provided.
The Impact Of Foreign Postings On Accompanying Military Spouses: An Ethnographic Study, G Blakely, C Hennessy, Mc Chung, H Skirton
The Impact Of Foreign Postings On Accompanying Military Spouses: An Ethnographic Study, G Blakely, C Hennessy, Mc Chung, H Skirton
Peninsula Dental School
As part of an ethnographic study, the impact of foreign postings on spouses who accompany military personnel was explored. Individual interviews and focus groups with 34 British military spouses based in one location in southern Europe were conducted. Key findings suggested that reaction to a foreign posting was a reflection of personal attitudes, prior experiences, support, ability to adjust to change and strength of relationship with the serving spouse and community. For many the experience was positive due to the increased opportunity for family time, for others this helped to compensate for the difficulties experienced. Some military spouses experienced significant …
Limpets Counteract Ocean Acidification Induced Shell Corrosion By Thickening Of Aragonitic Shell Layers, G. Langer, G. Nehrke, C. Baggini, R. Rodolfo-Metalpa, J. M. Hall-Spencer, J. Bijma
Limpets Counteract Ocean Acidification Induced Shell Corrosion By Thickening Of Aragonitic Shell Layers, G. Langer, G. Nehrke, C. Baggini, R. Rodolfo-Metalpa, J. M. Hall-Spencer, J. Bijma
School of Biological and Marine Sciences
Abstract. Specimens of the patellogastropod limpet Patella caerulea were collected within (pHlow-shells) and outside (pHn-shells) a CO2 vent site at Ischia, Italy. Four pHlow-shells and four pHn-shells were sectioned transversally and scanned for polymorph distribution by means of confocal Raman microscopy. The pHlow-shells displayed a twofold increase in aragonite area fraction and size normalised aragonite area. Size normalised calcite area was halved in pHlow-shells. Taken together with the increased apical and the decreased flank size normalised thickness of the pHlow-shells, these data led us to conclude that low pH exposed P. caerulea specimens counteract shell dissolution by enhanced shell production. …
Motor Contagion During Human-Human And Human-Robot Interaction, A Bisio, A Sciutti, F Nori, G Metta, Et Al
Motor Contagion During Human-Human And Human-Robot Interaction, A Bisio, A Sciutti, F Nori, G Metta, Et Al
School of Engineering, Computing and Mathematics
Motor resonance mechanisms are known to affect humans' ability to interact with others, yielding the kind of "mutual understanding" that is the basis of social interaction. However, it remains unclear how the partner's action features combine or compete to promote or prevent motor resonance during interaction. To clarify this point, the present study tested whether and how the nature of the visual stimulus and the properties of the observed actions influence observer's motor response, being motor contagion one of the behavioral manifestations of motor resonance. Participants observed a humanoid robot and a human agent move their hands into a pre-specified …
Integrating Metabolic Performance, Thermal Tolerance, And Plasticity Enables For More Accurate Predictions On Species Vulnerability To Acute And Chronic Effects Of Global Warming, S Magozzi, P Calosi
Integrating Metabolic Performance, Thermal Tolerance, And Plasticity Enables For More Accurate Predictions On Species Vulnerability To Acute And Chronic Effects Of Global Warming, S Magozzi, P Calosi
School of Biological and Marine Sciences
Predicting species vulnerability to global warming requires a comprehensive, mechanistic understanding of sublethal and lethal thermal tolerances. To date, however, most studies investigating species physiological responses to increasing temperature have focused on the underlying physiological traits of either acute or chronic tolerance in isolation. Here, we propose an integrative, synthetic approach including the investigation of multiple physiological traits (metabolic performance and thermal tolerance), and their plasticity, to provide more accurate and balanced predictions on species and assemblage vulnerability to both acute and chronic effects of global warming. We applied this approach to more accurately elucidate relative species vulnerability to warming …
Bifurcation Study Of Phase Oscillator Systems With Attractive And Repulsive Interaction, O Burylko, Y Kazanovich, R Borisyuk
Bifurcation Study Of Phase Oscillator Systems With Attractive And Repulsive Interaction, O Burylko, Y Kazanovich, R Borisyuk
School of Engineering, Computing and Mathematics
We study a model of globally coupled phase oscillators that contains two groups of oscillators with positive (synchronizing) and negative (desynchronizing) incoming connections for the first and second groups, respectively. This model was previously studied by Hong and Strogatz (the Hong-Strogatz model) in the case of a large number of oscillators. We consider a generalized Hong-Strogatz model with a constant phase shift in coupling. Our approach is based on the study of invariant manifolds and bifurcation analysis of the system. In the case of zero phase shift, various invariant manifolds are analytically described and a new dynamical mode is found. …
Scaling Up Experimental Ocean Acidification And Warming Research: From Individuals To The Ecosystem, Am Queirós, Ja Fernandes, S Faulwetter, P Calosi
Scaling Up Experimental Ocean Acidification And Warming Research: From Individuals To The Ecosystem, Am Queirós, Ja Fernandes, S Faulwetter, P Calosi
School of Biological and Marine Sciences
Understanding long-term, ecosystem-level impacts of climate change is challenging because experimental research frequently focuses on short-term, individual-level impacts in isolation. We address this shortcoming first through an interdisciplinary ensemble of novel experimental techniques to investigate the impacts of 14-month exposure to ocean acidification and warming (OAW) on the physiology, activity, predatory behaviour and susceptibility to predation of an important marine gastropod (Nucella lapillus). We simultaneously estimated the potential impacts of these global drivers on N. lapillus population dynamics and dispersal parameters. We then used these data to parameterize a dynamic bioclimatic envelope model, to investigate the consequences of OAW on …
Nuclear Her4 Mediates Acquired Resistance To Trastuzumab And Is Associated With Poor Outcome In Her2 Positive Breast Cancer, Sn Mohd Nafi, D Generali, G Kramer-Marek, M Gijsen, Et Al
Nuclear Her4 Mediates Acquired Resistance To Trastuzumab And Is Associated With Poor Outcome In Her2 Positive Breast Cancer, Sn Mohd Nafi, D Generali, G Kramer-Marek, M Gijsen, Et Al
School of Biomedical Sciences
The role of HER4 in breast cancer is controversial and its role in relation to trastuzumab resistance remains unclear. We showed that trastuzumab treatment and its acquired resistance induced HER4 upregulation, cleavage and nuclear translocation. However, knockdown of HER4 by specific siRNAs increased trastuzumab sensitivity and reversed its resistance in HER2 positive breast cancer cells. Preventing HER4 cleavage by a γ-secretase inhibitor and inhibiting HER4 tyrosine kinase activity by neratinib decreased trastuzumab-induced HER4 nuclear translocation and enhanced trastuzumab response. There was also increased nuclear HER4 staining in the tumours from BT474 xenograft mice and human patients treated with trastuzumab. Furthermore, …
Fine-Scale Hydrodynamics Influence The Spatio-Temporal Distribution Of Harbour Porpoises At A Coastal Hotspot, A. R. Jones, P. Hosegood, R. B. Wynn, Boer Mn De, S. Butler-Cowdry, C. B. Embling
Fine-Scale Hydrodynamics Influence The Spatio-Temporal Distribution Of Harbour Porpoises At A Coastal Hotspot, A. R. Jones, P. Hosegood, R. B. Wynn, Boer Mn De, S. Butler-Cowdry, C. B. Embling
School of Biological and Marine Sciences
No abstract provided.