Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (28)
- Physical Sciences and Mathematics (28)
- Engineering (26)
- Psychiatry and Psychology (24)
- Life Sciences (18)
-
- Marine Biology (11)
- Biology (6)
- Business (4)
- Tourism and Travel (4)
- Education (3)
- Social and Behavioral Sciences (2)
- Aerospace Engineering (1)
- Anthropology (1)
- Art and Design (1)
- Arts and Humanities (1)
- Chemistry (1)
- Cognitive Science (1)
- Dance (1)
- Disability and Equity in Education (1)
- East Asian Languages and Societies (1)
- Educational Methods (1)
- Educational Psychology (1)
- Educational Sociology (1)
- English Language and Literature (1)
- Environmental Sciences (1)
- Film and Media Studies (1)
- Gender Equity in Education (1)
- Gender and Sexuality (1)
- Interdisciplinary Arts and Media (1)
- Japanese Studies (1)
- Keyword
-
- Humans (142)
- Animals (92)
- Female (59)
- Climate change (58)
- Male (58)
-
- Biodiversity (50)
- Adult (35)
- Aquaculture (35)
- Conservation (34)
- Ecology (32)
- Middle Aged (31)
- Ecosystem (29)
- Microplastics (24)
- Fish (23)
- Marine (23)
- Models (22)
- Aged (20)
- Behaviour (20)
- Meningioma (20)
- Ocean acidification (20)
- Young Adult (20)
- Microplastic (19)
- Biogeography (18)
- Climate Change (18)
- Education (18)
- Sustainability (18)
- Ecosystem services (17)
- Environment (17)
- Fisheries (17)
- Hypoxia (17)
- Publication Year
- Publication
-
- School of Biological and Marine Sciences (2061)
- School of Geography, Earth and Environmental Sciences (631)
- Peninsula Medical School (535)
- School of Biological and Marine Sciences Theses (432)
- School of Engineering, Computing and Mathematics (388)
-
- School of Psychology (343)
- School of Biomedical Sciences (341)
- The Plymouth Student Scientist (281)
- School of Geography, Earth and Environmental Sciences Theses (215)
- Other Faculty of Science and Engineering Theses (201)
- School of Health Professions (158)
- School of Art, Design and Architecture (144)
- School of Engineering, Computing and Mathematics Theses (115)
- School of Nursing and Midwifery (110)
- Peninsula Dental School (106)
- Other Faculty of Health Theses (93)
- Other Faculty of Arts, Humanities and Business Theses (92)
- School of Law, Humanities and Social Sciences (62)
- School of Psychology Theses (52)
- More Faculty of Science and Engineering Research (45)
- Plymouth Business School (42)
- More Faculty of Health Research (38)
- Peninsula Medical School Theses (35)
- School of Art, Design and Architecture Theses (35)
- School of Law, Humanities and Social Sciences Theses (34)
- Plymouth Institute of Education (26)
- Faculty of Science and Engineering Datasets (22)
- Plymouth Business School Theses (21)
- School of Biomedical Sciences Theses (19)
- The Plymouth Law and Criminal Justice Review (19)
- Publication Type
- File Type
Articles 4861 - 4890 of 6794
Full-Text Articles in Entire DC Network
Xiap And Ciap1 Amplifications Induce Beclin 1-Dependent Autophagy Through Nfκb Activation., Fang Lin, Ghita Ghislat, Shouqing Luo, Maurizio Renna, Farah Siddiqi, David C. Rubinsztein
Xiap And Ciap1 Amplifications Induce Beclin 1-Dependent Autophagy Through Nfκb Activation., Fang Lin, Ghita Ghislat, Shouqing Luo, Maurizio Renna, Farah Siddiqi, David C. Rubinsztein
Peninsula Medical School
Perturbations in autophagy and apoptosis are associated with cancer development. XIAP and cIAP1 are two members of the inhibitors of apoptosis protein family whose expression is elevated in different cancers. Here we report that XIAP and cIAP1 induce autophagy by upregulating the transcription of Beclin 1, an essential autophagy gene. The E3 ubiquitin ligase activity of both proteins activates NFκB signalling, leading to the direct binding of p65 to the promoter of Beclin 1 and to its transcriptional activation. This mechanism may be relevant in cancer cells, since we found increased levels of autophagy in different B-cell lymphoma-derived cell lines …
Lateritic Plateaus In The Northern Western Ghats, India; A Review Of Bauxite Mining Restoration Practices, C Thorpe, A Watve
Lateritic Plateaus In The Northern Western Ghats, India; A Review Of Bauxite Mining Restoration Practices, C Thorpe, A Watve
School of Biological and Marine Sciences
In global consequences of rapidly changing climate and increased amphibian population decline, mapping amphibian diversity in biodiversity hotspots is essential. In this study we have systematically studied anurans of Phansad Wildlife Sanctuary in terms of species diversity, population structure, threat status and distribution. We recorded a total of 22 anuran species, of which 11 species are endemic to Western Ghats biodiversity hotspot. Family Dicroglossidae was found to be more species-rich. Spatial and temporal variation in anuran diversity was observed by using Shannon diversity and evenness indices. Most of the endemic and threatened anuran species are found to be associated with …
Keeping Patients With Epilepsy Safe: A Surmountable Challenge?, Rohit Shankar, Craig Newman, Jane Hanna, Juliet Ashton, Caryn Jory, Brendan Mclean, Tamsyn Anderson, Matthew Walker, David Cox, Liz Ewins
Keeping Patients With Epilepsy Safe: A Surmountable Challenge?, Rohit Shankar, Craig Newman, Jane Hanna, Juliet Ashton, Caryn Jory, Brendan Mclean, Tamsyn Anderson, Matthew Walker, David Cox, Liz Ewins
Peninsula Medical School
This quality improvement project was inspired as an answer to a problem that intellectual disability teams have been struggling to manage whilst caring for people with epilepsy (PWE). The issue was that despite guidance to discuss the possibility of sudden unexpected death in epilepsy (SUDEP) be discussed with a newly diagnosed PWE this is rarely done. Additionally when, how, and what to discuss about SUDEP and reduce its risk is arbitrary, non-person centred, and with no structured evidence.Prior to initiating changes a discussion of SUDEP was recorded in just 10% of PWE. We introduced a check-list to help identify risk …
A Paleoclimatic And Paleoatmospheric Record From Peatlands Accumulating During The Cretaceous-Paleogene Boundary Event, Western Interior Basin, Canada, Rhodri M. Jerrett, Gregory D. Price, Stephen T. Grimes, Alex T. Dawson
A Paleoclimatic And Paleoatmospheric Record From Peatlands Accumulating During The Cretaceous-Paleogene Boundary Event, Western Interior Basin, Canada, Rhodri M. Jerrett, Gregory D. Price, Stephen T. Grimes, Alex T. Dawson
School of Geography, Earth and Environmental Sciences
No abstract provided.
Coital Incontinence: What Can We Learn From Urodynamic Assessment?, K Madhu, H Hashim, Dg Enki, M Yaasin, M Drake
Coital Incontinence: What Can We Learn From Urodynamic Assessment?, K Madhu, H Hashim, Dg Enki, M Yaasin, M Drake
Peninsula Medical School
OBJECTIVE: To evaluate the association of coital incontinence (CI) with lower urinary tract symptoms (LUTS) and to understand the pathophysiology of CI. METHODS: A database of all women who underwent urodynamic testing in a tertiary referral center in the United Kingdom, from January 1991 to December 2009, was retrospectively analyzed. All women reporting CI were included in the study. Urodynamic testing and interpretation of results were performed in accordance with the recommendations of the International Continence Society. RESULTS: The prevalence of CI in women with LUTS undergoing urodynamics was 11.8%, and they were significantly younger (mean age = 45.3 years; …
Meta-Analysis Of Androgen Insensitivity In Preoperative Hormone Therapy In Hypospadias, W Zhao, J Yin, Z Yang, J Xie, Et Al
Meta-Analysis Of Androgen Insensitivity In Preoperative Hormone Therapy In Hypospadias, W Zhao, J Yin, Z Yang, J Xie, Et Al
Peninsula Medical School
OBJECTIVE: To define androgen insensitivity prevalence in hypospadias patients treated with preoperative hormone therapy. MATERIALS AND METHODS: We searched databases that were published in English and Chinese up to September 10, 2014 for our studies. Eligibility criteria were pre-established. Title, abstract, and full-text screenings were conducted by 2 authors independently. Discrepancies were resolved by consensus. Quality assessment of included studies was completed. Meta-analysis was done when appropriate using R, version 3.1.1 for Windows. Heterogeneity among individual studies was tested using the Cochran chi-square Q test and quantified by calculating the I(2) index. RESULTS: Thirteen of 1278 publications met inclusion criteria …
Distinct Lower Visual Field Preference For Object Shape, Gunnar Schmidtmann, Andrew J. Logan, Graeme J. Kennedy, Gael E. Gordon, Gunter Loffler
Distinct Lower Visual Field Preference For Object Shape, Gunnar Schmidtmann, Andrew J. Logan, Graeme J. Kennedy, Gael E. Gordon, Gunter Loffler
School of Health Professions
No abstract provided.
Can Polychlorinated Biphenyl (Pcb) Signatures And Enantiomer Fractions Be Used For Source Identification And To Age Date Occupational Exposure?, David Megson, Jean Françios Focant, Donald G. Patterson, Matthew Robson, Maeve C. Lohan, Paul J. Worsfold, Sean Comber, Robert Kalin, Eric Reiner, Gwen O'Sullivan
Can Polychlorinated Biphenyl (Pcb) Signatures And Enantiomer Fractions Be Used For Source Identification And To Age Date Occupational Exposure?, David Megson, Jean Françios Focant, Donald G. Patterson, Matthew Robson, Maeve C. Lohan, Paul J. Worsfold, Sean Comber, Robert Kalin, Eric Reiner, Gwen O'Sullivan
School of Geography, Earth and Environmental Sciences
Detailed polychlorinated biphenyl (PCB) signatures and chiral Enantiomer Fractions (EFs) of CB-95, CB-136 and CB-149 were measured for 30 workers at a transformer dismantling plant. This was undertaken to identify sources of exposure and investigate changes to the PCB signature and EFs over different exposure periods. Approximately 1.5 g of serum was extracted and PCB signatures were created through analysis by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC×GC-TOFMS) and EFs calculated following analysis by gas chromatography with high resolution mass spectrometry (GC-HRMS). A total of 84 PCBs were identified in the serum samples with concentrations of the 7 …
Physiological Advantages Of Dwarfing In Surviving Extinctions In High-Co2 Oceans, Vittorio Garilli, Riccardo Rodolfo-Metalpa, Danilo Scuderi, Lorenzo Brusca, Daniela Parrinello, Samuel P.S. Rastrick, Andy Foggo, Richard J. Twitchett, Jason M. Hall-Spencer, Marco Milazzo
Physiological Advantages Of Dwarfing In Surviving Extinctions In High-Co2 Oceans, Vittorio Garilli, Riccardo Rodolfo-Metalpa, Danilo Scuderi, Lorenzo Brusca, Daniela Parrinello, Samuel P.S. Rastrick, Andy Foggo, Richard J. Twitchett, Jason M. Hall-Spencer, Marco Milazzo
School of Biological and Marine Sciences
Excessive CO2 in the present-day ocean–atmosphere system is causing ocean acidification, and is likely to cause a severe biodiversity decline in the future1, mirroring eff ects in many past mass extinctions2–4. Fossil records demonstrate that organisms surviving such events were often smaller than those before5,6, a phenomenon called the Lilliput eff ect7. Here, we show that two gastropod species adapted to acidified seawater at shallow-water CO2 seeps were smaller than those found in normal pH conditions and had higher mass-specific energy consumption but significantly lower whole-animal metabolic energy demand. These physiological changes allowed the animals to maintain calcification and to …
The Comparative Osmoregulatory Ability Of Two Water Beetle Genera Whose Species Span The Fresh-Hypersaline Gradient In Inland Waters (Coleoptera: Dytiscidae, Hydrophilidae)., Susana Pallarés, Paula Arribas, David T. Bilton, Andrés Millán, Josefa Velasco
The Comparative Osmoregulatory Ability Of Two Water Beetle Genera Whose Species Span The Fresh-Hypersaline Gradient In Inland Waters (Coleoptera: Dytiscidae, Hydrophilidae)., Susana Pallarés, Paula Arribas, David T. Bilton, Andrés Millán, Josefa Velasco
School of Biological and Marine Sciences
A better knowledge of the physiological basis of salinity tolerance is essential to understanding the ecology and evolutionary history of organisms that have colonized inland saline waters. Coleoptera are amongst the most diverse macroinvertebrates in inland waters, including saline habitats; however, the osmoregulatory strategies they employ to deal with osmotic stress remain unexplored. Survival and haemolymph osmotic concentration at different salinities were examined in adults of eight aquatic beetle species which inhabit different parts of the fresh-hypersaline gradient. Studied species belong to two unrelated genera which have invaded saline waters independently from freshwater ancestors; Nebrioporus (Dytiscidae) and Enochrus (Hydrophilidae). Their …
Individual Differences In Activity And Habitat Selection Of Juvenile Queen Conch Evaluated Using Acceleration Biologgers, Jacob W. Brownscombe, Alexander D.M. Wilson, Emma Samson, Liane Nowell, Steven J. Cooke, Andy J. Danylchuk
Individual Differences In Activity And Habitat Selection Of Juvenile Queen Conch Evaluated Using Acceleration Biologgers, Jacob W. Brownscombe, Alexander D.M. Wilson, Emma Samson, Liane Nowell, Steven J. Cooke, Andy J. Danylchuk
School of Biological and Marine Sciences
No abstract provided.
Implementing A Patient-Initiated Review System In Rheumatoid Arthritis: A Qualitative Evaluation., Sue Child, Victoria A. Goodwin, Mark G. Perry, Christian A. Gericke, Richard Byng
Implementing A Patient-Initiated Review System In Rheumatoid Arthritis: A Qualitative Evaluation., Sue Child, Victoria A. Goodwin, Mark G. Perry, Christian A. Gericke, Richard Byng
Peninsula Medical School
BACKGROUND: The management of Rheumatoid Arthritis (RA), a chronic relapsing condition primarily affecting joints usually entails regular hospital reviews with a specialist. These reviews can occur when the patient is well. This study forms part of a service evaluation of a system wide implementation of a patient initiated review appointment system which we have called Direct Access (DA). The aim was to explore the experiences of patients and staff of a DA system in order to understand the process of the implementation and to identify potential improvements. METHODS: Twenty-three patients with RA that had completed one year of follow-up on …
Planning Robust Policing Futures: Modelling Using Multimethodology, Jonathan Moizer, David Carter, Shaofeng Liu
Planning Robust Policing Futures: Modelling Using Multimethodology, Jonathan Moizer, David Carter, Shaofeng Liu
Plymouth Business School
Purpose – The resourcing of policing activity is characterised by a level of complexity, particularly where evaluating alternative policy options is concerned. In this paper, a case study using multimethodological modelling to compare alternative policy choice in a group context is outlined with respect to response-patrol officer (RPO) deployment within a UK police force. The paper aims to discuss these issues. Design/methodology/approach – The application of a three phase modelling process is illustrated where scenario planning is used to generate the scope of the system elements to be modelled. This is followed by causal mapping to identify the barriers to …
Modeling Probability And Additive Summation For Detection Across Multiple Mechanisms Under The Assumptions Of Signal Detection Theory, Frederick A.A. Kingdom, Alex S. Baldwin, Gunnar Schmidtmann
Modeling Probability And Additive Summation For Detection Across Multiple Mechanisms Under The Assumptions Of Signal Detection Theory, Frederick A.A. Kingdom, Alex S. Baldwin, Gunnar Schmidtmann
School of Health Professions
No abstract provided.
Education For Sustainable Development: Towards The Sustainable University, S Deamicis, G Crust, C Mikhail, J Davidson, C Gristy, R Cutting, A Consorte-Mccrea, K Kosta, S Bessant, C Willmore, P Ofei-Manu, K Herweg, A Zimmermann, P Bray, L Wyness, P Rands
Education For Sustainable Development: Towards The Sustainable University, S Deamicis, G Crust, C Mikhail, J Davidson, C Gristy, R Cutting, A Consorte-Mccrea, K Kosta, S Bessant, C Willmore, P Ofei-Manu, K Herweg, A Zimmermann, P Bray, L Wyness, P Rands
School of Biological and Marine Sciences
We planned this conference in anticipation of the end of the UN Decade of Education for Sustainable Development (DESD), and the start of the next phase for those involved in ESD here and internationally. At Plymouth University, 2015 marks ten year anniversary since cross-‐institutional work on sustainability and sustainability education was spearheaded by the founding of the Centre for Sustainable Futures (CSF). Coincidentally, 2015 also marks a ten years since the influential HEFCE policy document ‘Sustainable Development in Higher Education’ was released. Holding the conference in January – named after the Roman god of doorways, of endings and beginnings – …
Ocean Acidification: How Will Marine Life Cope?, Jm Hall-Spencer
Ocean Acidification: How Will Marine Life Cope?, Jm Hall-Spencer
School of Biological and Marine Sciences
CO2 emissions are making the oceans more acidic. We’re still not sure what this will do to marine life, but in many places the result’s unlikely to be good. Jason Hall-Spencer describes his efforts to understand the impact by investigating places where the gas bubbles naturally from the seabed.
Evaluation Of Ecosystem-Based Marine Management Strategies Based On Risk Assessment, Gj Piet, Rh Jongbloed, Am Knights, Je Tamis, Et Al
Evaluation Of Ecosystem-Based Marine Management Strategies Based On Risk Assessment, Gj Piet, Rh Jongbloed, Am Knights, Je Tamis, Et Al
School of Biological and Marine Sciences
This study presents a comprehensive and generic framework that provides a typology for the identification and selection of consistently defined ecosystem-based management measures and allows a coherent evaluation of these measures based on their performance to achieve policy objectives. The performance is expressed in terms of their reduction of risk of an adverse impact on the marine ecosystem. This typology consists of two interlinked aspects of a measure, i.e. the "Focus" and the "Type". The "Focus" is determined by the part of the impact chain (Driver-Pressure-State) the measure is supposed to mitigate or counteract. The "Type" represents the physical measure …
Lactobacillus Rhamnosus Lowers Zebrafish Lipid Content By Changing Gut Microbiota And Host Transcription Of Genes Involved In Lipid Metabolism., Silvia Falcinelli, Simona Picchietti, Ana Rodiles, Lina Cossignani, Daniel L. Merrifield, Anna Rita Taddei, Francesca Maradonna, Ike Olivotto, Giorgia Gioacchini, Oliana Carnevali
Lactobacillus Rhamnosus Lowers Zebrafish Lipid Content By Changing Gut Microbiota And Host Transcription Of Genes Involved In Lipid Metabolism., Silvia Falcinelli, Simona Picchietti, Ana Rodiles, Lina Cossignani, Daniel L. Merrifield, Anna Rita Taddei, Francesca Maradonna, Ike Olivotto, Giorgia Gioacchini, Oliana Carnevali
School of Biological and Marine Sciences
The microbiome plays an important role in lipid metabolism but how the introduction of probiotic communities affects host lipid metabolism is poorly understood. Using a multidisciplinary approach we addressed this knowledge gap using the zebrafish model by coupling high-throughput sequencing with biochemical, molecular and morphological analysis to evaluate the changes in the intestine. Analysis of bacterial 16S libraries revealed that Lactobacillus rhamnosus was able to modulate the gut microbiome of zebrafish larvae, elevating the abundance of Firmicutes sequences and reducing the abundance of Actinobacteria. The gut microbiome changes modulated host lipid processing by inducing transcriptional down-regulation of genes involved in …
Hco3(-)-Independent Ph Regulation In Astrocytes In Situ Is Dominated By V-Atpase., Daniel Bloch Hansen, Nestor Garrido-Comas, Mike Salter, Robert Fern
Hco3(-)-Independent Ph Regulation In Astrocytes In Situ Is Dominated By V-Atpase., Daniel Bloch Hansen, Nestor Garrido-Comas, Mike Salter, Robert Fern
More Faculty of Health Research
The mechanisms of HCO3(-)-independent intracellular pH (pHi) regulation were examined in fibrous astrocytes within isolated neonatal rat optic nerve (RON) and in cultured cortical astrocytes. In agreement with previous studies, resting pHi in cultured astrocytes was 6.82 ± 0.06 and inhibition of the V-ATPase H(+) pump by Cl(-) removal or via the selective inhibitor bafilomycin had only a small effect upon resting pHi and recovery following an acid load. In contrast, resting pHi in RON astrocytes was 7.10 ± 0.04, significantly less acidic than that in cultured cells (p < 0.001), and responded to inhibition of V-ATPase with profound acidification to the 6.3-6.5 range. Fluorescent immuno-staining and immuno-gold labeling confirmed the presence V-ATPase in the cell membrane of RON astrocyte processes and somata. Using ammonia pulse recovery, pHi recovery in RON astrocyte was achieved largely via V-ATPase with sodium-proton exchange (NHE) playing a minor role. The findings indicate that astrocytes in a whole-mount preparation such as the optic nerve rely to a greater degree upon V-ATPase for HCO3(-)-independent pHi regulation than do cultured astrocytes, with important functional consequences for the regulation of pH in the CNS.
Sticky Stuff: Redefining Bedform Prediction In Modern And Ancient Environments, Robert J. Schindler, Daniel R. Parsons, Leiping Ye, Julie A. Hope, Jaco H. Baas, Jeff Peakall, Andrew J. Manning, Rebecca J. Aspden, Jonathan Malarkey, Steve Simmons, David M. Paterson, Ian D. Lichtman, Alan G. Davies, Peter D. Thorne, Sarah J. Bass
Sticky Stuff: Redefining Bedform Prediction In Modern And Ancient Environments, Robert J. Schindler, Daniel R. Parsons, Leiping Ye, Julie A. Hope, Jaco H. Baas, Jeff Peakall, Andrew J. Manning, Rebecca J. Aspden, Jonathan Malarkey, Steve Simmons, David M. Paterson, Ian D. Lichtman, Alan G. Davies, Peter D. Thorne, Sarah J. Bass
School of Geography, Earth and Environmental Sciences
The dimensions and dynamics of subaqueous bedforms are well known for cohesionless sediments. However, the effect of physical cohesion imparted by cohesive clay within mixed sand-mud substrates has not been examined, despite its recognized influence on sediment stability. Here we present a series of controlled laboratory experiments to establish the influence of substrate clay content on subaqueous bedform dynamics within mixtures of sand and clay exposed to unidirectional flow. The results show that bedform dimensions and steepness decrease linearly with clay content, and comparison with existing predictors of bedform dimensions, established within cohesionless sediments, reveals significant over-prediction of bedform size …
Review Of Nanomaterials In Dentistry: Interactions With The Oral Microenvironment, Clinical Applications, Hazards, And Benefits., Alexandros Besinis, Peralta T De, Christopher J. Tredwin, Richard D. Handy
Review Of Nanomaterials In Dentistry: Interactions With The Oral Microenvironment, Clinical Applications, Hazards, And Benefits., Alexandros Besinis, Peralta T De, Christopher J. Tredwin, Richard D. Handy
School of Engineering, Computing and Mathematics
Interest in the use of engineered nanomaterials (ENMs) as either nanomedicines or dental materials/devices in clinical dentistry is growing. This review aims to detail the ultrafine structure, chemical composition, and reactivity of dental tissues in the context of interactions with ENMs, including the saliva, pellicle layer, and oral biofilm; then describes the applications of ENMs in dentistry in context with beneficial clinical outcomes versus potential risks. The flow rate and quality of saliva are likely to influence the behavior of ENMs in the oral cavity, but how the protein corona formed on the ENMs will alter bioavailability, or interact with …
Individual Quality And Personality: Bolder Males Are Less Fecund In The Hermit Crab Pagurus Bernhardus., Danielle Bridger, Simon J. Bonner, Mark Briffa
Individual Quality And Personality: Bolder Males Are Less Fecund In The Hermit Crab Pagurus Bernhardus., Danielle Bridger, Simon J. Bonner, Mark Briffa
School of Biological and Marine Sciences
One explanation for animal personality is that different behavioural types derive from different life-history strategies. Highly productive individuals, with high growth rates and high fecundity, are assumed to live life at a fast pace showing high levels of boldness and risk taking, compared with less productive individuals. Here, we investigate among-individual differences in mean boldness (the inverse of the latency to recover from a startling stimulus) and in the consistency of boldness, in male hermit crabs in relation to two aspects of life-history investment. We assessed aerobic scope by measuring the concentration of the respiratory pigment haemocyanin, and we assessed …
Combining Lapatinib And Pertuzumab To Overcome Lapatinib Resistance Due To Nrg1-Mediated Signalling In Her2-Amplified Breast Cancer, W-Y Leung, I Roxanis, H Sheldon, Fm Buffa, Et Al
Combining Lapatinib And Pertuzumab To Overcome Lapatinib Resistance Due To Nrg1-Mediated Signalling In Her2-Amplified Breast Cancer, W-Y Leung, I Roxanis, H Sheldon, Fm Buffa, Et Al
School of Biomedical Sciences
Acquired resistance to lapatinib, an inhibitor of EGFR and HER2 kinases, is common. We found that reactivation of EGFR, HER2 and HER3 occurred within 24 hours of lapatinib treatment after their initial dephosphorylation. This was associated with increased expression of NRG1 in cells treated with lapatinib. Exogenous NRG1 partially rescued breast cancer cells from growth inhibition by lapatinib. In addition, both parental and lapatinib-resistant breast cancer cells were sensitive to SGP1, which inhibits binding of NRG1 and other HER3 ligands. Addition of pertuzumab to lapatinib further inhibited NRG1-induced signalling, which was not fully inhibited by either drug alone. In animal …
Photosynthetic And Biochemical Characterization Of In Vitro-Derived African Violet (Saintpaulia Ionantha H. Wendl) Plants To Ex Vitro Conditions, Yaser Hassan Dewir, Mohammed El Sayed El-Mahrouk, Hanady Salim Al-Shmgani, Hail Z. Rihan, Silva Jat Da, Michael P. Fuller
Photosynthetic And Biochemical Characterization Of In Vitro-Derived African Violet (Saintpaulia Ionantha H. Wendl) Plants To Ex Vitro Conditions, Yaser Hassan Dewir, Mohammed El Sayed El-Mahrouk, Hanady Salim Al-Shmgani, Hail Z. Rihan, Silva Jat Da, Michael P. Fuller
School of Biological and Marine Sciences
No abstract provided.
Posture Affects How Robots And Infants Map Words To Objects, Af Morse, Vl Benitez, T Belpaeme, A Cangelosi, Lb Smith
Posture Affects How Robots And Infants Map Words To Objects, Af Morse, Vl Benitez, T Belpaeme, A Cangelosi, Lb Smith
School of Engineering, Computing and Mathematics
For infants, the first problem in learning a word is to map the word to its referent; a second problem is to remember that mapping when the word and/or referent are again encountered. Recent infant studies suggest that spatial location plays a key role in how infants solve both problems. Here we provide a new theoretical model and new empirical evidence on how the body – and its momentary posture – may be central to these processes. The present study uses a name-object mapping task in which names are either encountered in the absence of their target (experiments 1–3, 6 …
University Of Canberra, Bachelor Of Secondary Education (Health And Physical Education) Course Review And Development., Tj Lynch
Plymouth Institute of Education
This review is being completed during an opportunistic time in Higher Education Initial Teacher Education for the Australian Health and Physical Education (HPE) learning area. It is pertinent that this current HPE context is examined and the history is acknowledged when planning for the future.
Coastal Cliff Ground Motions And Response To Extreme Storm Waves, Claire S. Earlie, Adam P. Young, Gerd Masselink, Paul E. Russell
Coastal Cliff Ground Motions And Response To Extreme Storm Waves, Claire S. Earlie, Adam P. Young, Gerd Masselink, Paul E. Russell
School of Biological and Marine Sciences
No abstract provided.
Public Understanding And Knowledge Of Rip Currents And Beach Safety, Eleanor Woodward, Emily Beaumont, Paul Russell, Ross Macleod
Public Understanding And Knowledge Of Rip Currents And Beach Safety, Eleanor Woodward, Emily Beaumont, Paul Russell, Ross Macleod
School of Biological and Marine Sciences
No abstract provided.
Investigating A Link Of Two Different Types Of Food Business Management To The Food Safety Knowledge, Attitudes And Practices Of Food Handlers In Beirut, Lebanon, Dima Faour-Klingbeil, Victor Kuri, Ewen Todd
Investigating A Link Of Two Different Types Of Food Business Management To The Food Safety Knowledge, Attitudes And Practices Of Food Handlers In Beirut, Lebanon, Dima Faour-Klingbeil, Victor Kuri, Ewen Todd
School of Biological and Marine Sciences
Although Lebanon has a flourishing traditional and modern food businesses, which are typical both Middle Eastern (ME) and Mediterranean cuisines, knowledge and practice of food safety performance of the food service sector are limited in the whole ME region and lacking in Lebanon. To address this, a survey was conducted in Beirut to evaluate the knowledge, attitudes and practices related to food safety issues of food handlers (n = 80) in food service establishments (n = 50) and to assess the influence of management type on enactment of safe practices on food premises. Our data suggest that while respondents have …
Primare/ Swmep Priorities Scoping Workshop Agenda, C Perez-Collazo, D Greaves
Primare/ Swmep Priorities Scoping Workshop Agenda, C Perez-Collazo, D Greaves
School of Engineering, Computing and Mathematics
No abstract provided.