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Permanent Draft Genome Of ‘Rhodopirellula Islandica’ Strain K833, J Kizina, M Žure, E Rhiel, Et Al Dec 2015

Permanent Draft Genome Of ‘Rhodopirellula Islandica’ Strain K833, J Kizina, M Žure, E Rhiel, Et Al

School of Biological and Marine Sciences

The planctomycete strain K833 was isolated from cold waters at the coast of Island and is tentatively named 'Rhodopirellula islandica'. It has a lower temperature range for growth than other genome-sequenced Rhodopirellula strains affiliating to Rhodopirellula baltica and 'Rhodopirellula europaea'. The permanent draft genome of strain K833 was obtained as part of a larger study on the biogeography of Rhodopirellula species in European marine waters. The genome consists of 55 contigs with a genome size of 7,433,200 bp. With an average nucleotide identity of 81% to related genomes of R. baltica and 'R. europaea' and more than 4000 common genes, …


Marine Microphytobenthic Assemblage Shift Along A Natural Shallow-Water Co2 Gradient Subjected To Multiple Environmental Stressors, Vivienne R. Johnson, Colin Brownlee, Marco Milazzo, Jason M. Hall-Spencer Dec 2015

Marine Microphytobenthic Assemblage Shift Along A Natural Shallow-Water Co2 Gradient Subjected To Multiple Environmental Stressors, Vivienne R. Johnson, Colin Brownlee, Marco Milazzo, Jason M. Hall-Spencer

School of Biological and Marine Sciences

No abstract provided.


Generalisation, Decision Making, And Embodiment Effects In Mental Rotation: A Neurorobotic Architecture Tested With A Humanoid Robot, K Seepanomwan, D Caligiore, A Cangelosi, G Baldassarre Dec 2015

Generalisation, Decision Making, And Embodiment Effects In Mental Rotation: A Neurorobotic Architecture Tested With A Humanoid Robot, K Seepanomwan, D Caligiore, A Cangelosi, G Baldassarre

School of Engineering, Computing and Mathematics

Mental rotation, a classic experimental paradigm of cognitive psychology, tests the capacity of humans to mentally rotate a seen object to decide if it matches a target object. In recent years, mental rotation has been investigated with brain imaging techniques to identify the brain areas involved. Mental rotation has also been investigated through the development of neural-network models, used to identify the specific mechanisms that underlie its process, and with neurorobotics models to investigate its embodied nature. Current models, however, have limited capacities to relate to neuro-scientific evidence, to generalise mental rotation to new objects, to suitably represent decision making …


Identification Of Paleo Arctic Winter Sea Ice Limits And The Marginal Ice Zone: Optimised Biomarker-Based Reconstructions Of Late Quaternary Arctic Sea Ice, Simon T. Belt, Patricia Cabedo-Sanz, Lukas Smik, Alba Navarro-Rodriguez, Sarah M.P. Berben, Jochen Knies, Katrine Husum Dec 2015

Identification Of Paleo Arctic Winter Sea Ice Limits And The Marginal Ice Zone: Optimised Biomarker-Based Reconstructions Of Late Quaternary Arctic Sea Ice, Simon T. Belt, Patricia Cabedo-Sanz, Lukas Smik, Alba Navarro-Rodriguez, Sarah M.P. Berben, Jochen Knies, Katrine Husum

School of Geography, Earth and Environmental Sciences

No abstract provided.


Integrated Genomic Approaches Identify Major Pathways And Upstream Regulators In Late Onset Alzheimer's Disease, X Li, J Long, T He, R Belshaw, J Scott Dec 2015

Integrated Genomic Approaches Identify Major Pathways And Upstream Regulators In Late Onset Alzheimer's Disease, X Li, J Long, T He, R Belshaw, J Scott

School of Biomedical Sciences

Previous studies have evaluated gene expression in Alzheimer’s disease (AD) brains to identify mechanistic processes, but have been limited by the size of the datasets studied. Here we have implemented a novel meta-analysis approach to identify differentially expressed genes (DEGs) in published datasets comprising 450 late onset AD (LOAD) brains and 212 controls. We found 3124 DEGs, many of which were highly correlated with Braak stage and cerebral atrophy. Pathway Analysis revealed the most perturbed pathways to be (a) nitric oxide and reactive oxygen species in macrophages (NOROS), (b) NFkB and (c) mitochondrial dysfunction. NOROS was also up-regulated and mitochondrial …


Speculative Somatics, Ds Maranan Dec 2015

Speculative Somatics, Ds Maranan

School of Art, Design and Architecture

Based on a presentation at The Undivided Mind conference at Plymouth University, this article sketches out speculative applications of somatics, the first person, phenomenological study of sensation, perception and movement. I first introduce the subject of somatics through an experiential exercise for the reader before summarizing theoretical aspects of somatic study. Drawing from the literature in embodied cognition and from personal recollections of embodied experiences, I propose how somatic approaches could potentially be used in working with immigrant communities, living in outer space, and empathizing with non-human animals.


Mental Health Handbook For Schools, Mary Atkinson, Garry Hornby Nov 2015

Mental Health Handbook For Schools, Mary Atkinson, Garry Hornby

More Faculty of Arts, Humanities and Business Research

No abstract provided.


Igf-1r Inhibition Induces Schedule-Dependent Sensitization Of Human Melanoma To Temozolomide, R Ramcharan, T Aleksic, Wp Kamdoum, S Gao, Et Al Nov 2015

Igf-1r Inhibition Induces Schedule-Dependent Sensitization Of Human Melanoma To Temozolomide, R Ramcharan, T Aleksic, Wp Kamdoum, S Gao, Et Al

School of Biomedical Sciences

Prior studies implicate type 1 IGF receptor (IGF-1R) in mediating chemo-resistance. Here, we investigated whether IGF-1R influences response to temozolomide (TMZ), which generates DNA adducts that are removed by O6-methylguanine-DNA methyltransferase (MGMT), or persist causing replication-associated double-strand breaks (DSBs). Initial assessment in 10 melanoma cell lines revealed that TMZ resistance correlated with MGMT expression (r = 0.79, p = 0.009), and in MGMT-proficient cell lines, with phospho-IGF-1R (r = 0.81, p = 0.038), suggesting that TMZ resistance associates with IGF-1R activation. Next, effects of IGF-1R inhibitors (IGF-1Ri) AZ3801 and linsitinib (OSI-906) were tested on TMZ-sensitivity, cell cycle progression and DSB …


Playing The 'Blame Game': Accounting And The Construction Of Disruptive Behaviour In Family Interviews, G Blanchard, Tc Auburn, R Dallos Nov 2015

Playing The 'Blame Game': Accounting And The Construction Of Disruptive Behaviour In Family Interviews, G Blanchard, Tc Auburn, R Dallos

More Faculty of Health Research

Systemic conceptualisations suggest that family processes which involve blaming and holding the child accountable for their behaviour play an important role in the maintenance of disruptive behaviour problems. Discourse analytic work in family therapy settings has shown that accountability for the family’s reported problems is a key concern for family members. This study used a conversation analytic (CA) approach to examine family members’ accounts of child disruptive behaviour. The two participating families were both engaged in family therapy for disruptive behaviour problems. Each family participated in a family interview which was recorded and transcribed according to CA principles. The analysis …


Enhanced Cross-Limb Transfer Of Force Field Learning For Dynamics That Are Identical In Extrinsic And Joint-Based Coordinates For Both Limbs, Timothy J. Carroll, Aymar De Rugy, Ian S. Howard, James N. Ingram, Daniel M. Wolpert Nov 2015

Enhanced Cross-Limb Transfer Of Force Field Learning For Dynamics That Are Identical In Extrinsic And Joint-Based Coordinates For Both Limbs, Timothy J. Carroll, Aymar De Rugy, Ian S. Howard, James N. Ingram, Daniel M. Wolpert

School of Engineering, Computing and Mathematics

Humans are able to adapt their motor commands in order to make accurate movements in novel sensorimotor environments, such as when wielding tools that alter limb dynamics. However, it is unclear to what extent sensorimotor representations obtained through experience with one limb are available to the opposite, untrained limb, and in which form they are available. Here we compared cross-limb transfer of force-field compensation after participants adapted to a velocity-dependent curl field oriented either in the sagittal or the transverse plane. Due to the mirror symmetry of the limbs, the force field had identical effects for both limbs in joint …


The Impact Of Tertiary Wastewater Treatment On Copper And Zinc Complexation, C. Constantino, M. Gardner, S. D.W. Comber, M. D. Scrimshaw, B. Ellor Nov 2015

The Impact Of Tertiary Wastewater Treatment On Copper And Zinc Complexation, C. Constantino, M. Gardner, S. D.W. Comber, M. D. Scrimshaw, B. Ellor

School of Geography, Earth and Environmental Sciences

No abstract provided.


Antioxidative Capacity And Electrolyte Leakage In Healthy Versus Phytoplasma Infected Tissues Of Euphorbia Coerulescens And Orbea Gigantean, Yh Dewir, Mahrouk Me El, Hz Rihan, Ca Sáez, Mp Fuller Nov 2015

Antioxidative Capacity And Electrolyte Leakage In Healthy Versus Phytoplasma Infected Tissues Of Euphorbia Coerulescens And Orbea Gigantean, Yh Dewir, Mahrouk Me El, Hz Rihan, Ca Sáez, Mp Fuller

School of Biological and Marine Sciences

The present study reports on reactive oxygen species (ROS), antioxidant enzyme activities, electrolyte leakage and levels of abscisic acid (ABA) in healthy and phytoplasma infected (PI) tissues of Euphorbia coerulescens and Orbea gigantea. Histochemical staining for ROS indicated that PI tissues possess higher levels of hydrogen peroxide (H2O2) rather than superoxide (O2 ·-) as compared with healthy tissues in both plant species. The results indicated that superoxide dismutase (SOD) is not playing an important role in eliminating O2− in PI tissues. This was confirmed by a significantly decreased activity of SOD and a non-significant difference in O2 ·- content in …


A Cognitive Neural Architecture Able To Learn And Communicate Through Natural Language, B Golosio, A Cangelosi, O Gamotina, Gl Masala Nov 2015

A Cognitive Neural Architecture Able To Learn And Communicate Through Natural Language, B Golosio, A Cangelosi, O Gamotina, Gl Masala

School of Engineering, Computing and Mathematics

Communicative interactions involve a kind of procedural knowledge that is used by the human brain for processing verbal and nonverbal inputs and for language production. Although considerable work has been done on modeling human language abilities, it has been difficult to bring them together to a comprehensive tabula rasa system compatible with current knowledge of how verbal information is processed in the brain. This work presents a cognitive system, entirely based on a large-scale neural architecture, which was developed to shed light on the procedural knowledge involved in language elaboration. The main component of this system is the central executive, …


Thermal Imaging To Study Stress Non-Invasively In Unrestrained Birds, Paul Jerem, Katherine Herborn, Dominic Mccafferty, Dorothy Mckeegan, Ruedi Nager Nov 2015

Thermal Imaging To Study Stress Non-Invasively In Unrestrained Birds, Paul Jerem, Katherine Herborn, Dominic Mccafferty, Dorothy Mckeegan, Ruedi Nager

School of Biological and Marine Sciences

No abstract provided.


The Impact Of Co2 Emissions On 'Nuisance' Marine Species, Jm Hall-Spencer, R Allen Nov 2015

The Impact Of Co2 Emissions On 'Nuisance' Marine Species, Jm Hall-Spencer, R Allen

School of Biological and Marine Sciences

Anthropogenic CO2 emissions are being taken up from the atmosphere by the oceans, increasing the availability of dissolved inorganic carbon but reducing both the carbonate saturation and pH of seawater. This ocean acidification affects biological processes in a wide range of marine taxa. Here, we assess the likely responses of 'nuisance' species to ocean acidification, meaning those organisms that have undesirable effects from a human perspective. Based on a synthesis of evidence available to date, we predict increased growth and toxicity in harmful algal bloom species, and a significant increase in invasive algae in response to increased CO2 availability. Blooms …


Hyperdominance In Amazonian Forest Carbon Cycling, Sophie Fauset, Michelle O. Johnson, Manuel Gloor, Timothy R. Baker, M. A Monteagudo, Roel J.W. Brienen, Ted R. Feldpausch, Gabriela Lopez-Gonzalez, Yadvinder Malhi, Steege H Ter, Nigel C.A. Pitman, Christopher Baraloto, Julien Engel, Pascal Pétronelli, Ana Andrade, José Luís C. Camargo, Sgw Laurance, Wf Laurance, Jerôme Chave, Elodie Allie, Percy Núñez Vargas, John W. Terborgh, Kalle Ruokolainen, Marcos Silveira, C. Ga Aymard, Luzmila Arroyo, Damien Bonal, Hirma Ramirez-Angulo, Alejandro Araujo-Murakami, David Neill, Bruno Hérault, Aurélie Dourdain, Armando Torres-Lezama, Beatriz S. Marimon, Rafael P. Salomão, James A. Comiskey, Maxime Réjou-Méchain, Marisol Toledo, Juan Carlos Licona, Alfredo Alarcón, Adriana Prieto, Agustín Rudas, Der Meer Pj Van, Timothy J. Killeen, Beatriz S. Marimon, Lourens Poorter, Rene G.A. Boot, Basil Stergios, Emilio Vilanova Torre, Flávia R.C. Costa, Carolina Levis, Juliana Schietti, Priscila Souza, Nikée Groot, Eric Arets, Victor Chama Moscoso, Wendeson Castro, Euridice N.Honorio Coronado, Marielos Peña-Claros, Clement Stahl, Jorcely Barroso, Joey Talbot, Icg Vieira, Der Heijden G Van, Raquel Thomas, Vincent A. Vos, Everton C. Almeida, Esteban Álvarez Davila, Luiz E.O.C. Aragão, Terry L. Erwin, Paulo S. Morandi, Oliveira Ea De, Marco B.X. Valadão, Roderick J. Zagt, Der Hout P Van, Patricia Alvarez Loayza, John J. Pipoly, Ophelia Wang, Miguel Alexiades, Carlos E. Cerón, Isau Huamantupa-Chuquimaco, Fiore A Di Nov 2015

Hyperdominance In Amazonian Forest Carbon Cycling, Sophie Fauset, Michelle O. Johnson, Manuel Gloor, Timothy R. Baker, M. A Monteagudo, Roel J.W. Brienen, Ted R. Feldpausch, Gabriela Lopez-Gonzalez, Yadvinder Malhi, Steege H Ter, Nigel C.A. Pitman, Christopher Baraloto, Julien Engel, Pascal Pétronelli, Ana Andrade, José Luís C. Camargo, Sgw Laurance, Wf Laurance, Jerôme Chave, Elodie Allie, Percy Núñez Vargas, John W. Terborgh, Kalle Ruokolainen, Marcos Silveira, C. Ga Aymard, Luzmila Arroyo, Damien Bonal, Hirma Ramirez-Angulo, Alejandro Araujo-Murakami, David Neill, Bruno Hérault, Aurélie Dourdain, Armando Torres-Lezama, Beatriz S. Marimon, Rafael P. Salomão, James A. Comiskey, Maxime Réjou-Méchain, Marisol Toledo, Juan Carlos Licona, Alfredo Alarcón, Adriana Prieto, Agustín Rudas, Der Meer Pj Van, Timothy J. Killeen, Beatriz S. Marimon, Lourens Poorter, Rene G.A. Boot, Basil Stergios, Emilio Vilanova Torre, Flávia R.C. Costa, Carolina Levis, Juliana Schietti, Priscila Souza, Nikée Groot, Eric Arets, Victor Chama Moscoso, Wendeson Castro, Euridice N.Honorio Coronado, Marielos Peña-Claros, Clement Stahl, Jorcely Barroso, Joey Talbot, Icg Vieira, Der Heijden G Van, Raquel Thomas, Vincent A. Vos, Everton C. Almeida, Esteban Álvarez Davila, Luiz E.O.C. Aragão, Terry L. Erwin, Paulo S. Morandi, Oliveira Ea De, Marco B.X. Valadão, Roderick J. Zagt, Der Hout P Van, Patricia Alvarez Loayza, John J. Pipoly, Ophelia Wang, Miguel Alexiades, Carlos E. Cerón, Isau Huamantupa-Chuquimaco, Fiore A Di

School of Geography, Earth and Environmental Sciences

Abstract While Amazonian forests are extraordinarily diverse, the abundance of trees is skewed strongly towards relatively few ‘hyperdominant’ species. In addition to their diversity, Amazonian trees are a key component of the global carbon cycle, assimilating and storing more carbon than any other ecosystem on Earth. Here we ask, using a unique data set of 530 forest plots, if the functions of storing and producing woody carbon are concentrated in a small number of tree species, whether the most abundant species also dominate carbon cycling, and whether dominant species are characterized by specific functional traits. We find that dominance of …


Stereotypic Mice Are Aggressed By Their Cage-Mates, And Tend To Be Poor Demonstrators In Social Learning Tasks, L Harper, E Choleris, K Ervin, C Fureix, Et Al Nov 2015

Stereotypic Mice Are Aggressed By Their Cage-Mates, And Tend To Be Poor Demonstrators In Social Learning Tasks, L Harper, E Choleris, K Ervin, C Fureix, Et Al

School of Biological and Marine Sciences

Stereotypic behaviours (SBs) are linked with behavioural inflexibility and resemble symptoms of autism, suggesting that stereotypic animals could have autistic-like social impairments. SBs are also common in caged mice. We therefore hypothesised relationships between stereotypic and social behaviours, predicting that highly stereotypic mice would give/receive more agonism and be less effective in social learning tasks. Experiment One used C57BL/6 and DBA/2 mice in non-enriched or enriched housing (15 cages each); Experiment Two, more cages (six non-enriched, 44 enriched) plus a third strain (BALB/c). Across both experiments, enrichment reduced SB and agonism (aggression, plus ‘displacements’ where one mouse supplants another at …


Plants And Climate Change: Complexities And Surprises, Camille Parmesan, Mick E. Hanley Nov 2015

Plants And Climate Change: Complexities And Surprises, Camille Parmesan, Mick E. Hanley

School of Biological and Marine Sciences

No abstract provided.


Fast, Ultrasensitive Detection Of Reactive Oxygen Species Using A Carbon Nanotube Based-Electrocatalytic Intracellular Sensor, Frankie J. Rawson, Jacqueline Hicks, Nicholas Dodd, Wondwossen Abate, David J. Garrett, Nga Yip, Gyorgy Fejer, Alison J. Downard, Kim H.R. Baronian, Simon K. Jackson, Paula M. Mendes Oct 2015

Fast, Ultrasensitive Detection Of Reactive Oxygen Species Using A Carbon Nanotube Based-Electrocatalytic Intracellular Sensor, Frankie J. Rawson, Jacqueline Hicks, Nicholas Dodd, Wondwossen Abate, David J. Garrett, Nga Yip, Gyorgy Fejer, Alison J. Downard, Kim H.R. Baronian, Simon K. Jackson, Paula M. Mendes

School of Biomedical Sciences

No abstract provided.


Cognitive Innovation And The Cognitive Turn, M Punt Oct 2015

Cognitive Innovation And The Cognitive Turn, M Punt

School of Art, Design and Architecture

For nearly half a century Leonardo has surveyed, reflected and shaped the intellectual project of ISAST. As part of this mission it has, in the best possible sense, been alert to ‘the next big thing’; what in the sciences is called a ‘breakthrough’, a ‘movement’ in the arts, and in technology an ‘opportunity’. In recent years in the humanities the ‘next big thing’ has been relentlessly labelled as a ‘turn’ to the extent that the term itself now resonates with self-irony. Nonetheless by tracking the bibliographies of various ‘breakthroughs’, ‘movements’, ‘opportunities’ and ‘turns’, it is possible to see the recurring …


The Influence Of Data Resolution On Predicted Distribution And Estimates Of Extent Of Current Protection Of Three 'Listed' Deep-Sea Habitats, Lk Ross, Re Ross, Heather A. Stewart, Kerry L. Howell Oct 2015

The Influence Of Data Resolution On Predicted Distribution And Estimates Of Extent Of Current Protection Of Three 'Listed' Deep-Sea Habitats, Lk Ross, Re Ross, Heather A. Stewart, Kerry L. Howell

School of Biological and Marine Sciences

No abstract provided.


Synergistic Androgenic Effect Of A Petroleum Product Caused By The Joint Action Of At Least Three Different Types Of Compounds, Michiel T.O. Jonker, Angelica Candido, Cozmina M. Vrabie, Alan G. Scarlett, Steven J. Rowland Oct 2015

Synergistic Androgenic Effect Of A Petroleum Product Caused By The Joint Action Of At Least Three Different Types Of Compounds, Michiel T.O. Jonker, Angelica Candido, Cozmina M. Vrabie, Alan G. Scarlett, Steven J. Rowland

More Faculty of Science and Engineering Research

In a previous study, we found a dose-dependent synergistic effect in recombinant yeast stably transfected with the human androgen receptor (AR), in response to co-exposure to testosterone and a commercially-available lubricant (engine) oil for cars. As there is relatively little knowledge on synergistic toxic effects and causative compounds, particularly for the androgenic system, the objective of the present study was to investigate this oil in more detail. The oil was fractionated into SARA fractions (so-called 'saturates', 'aromatics', 'resins', and 'asphaltenes') by open column chromatography. Surprisingly, when exposing the recombinant AR yeast to testosterone in combination with the separate SARA fractions, …


Burkholderia Pseudomallei Capsular Polysaccharide Recognition By A Monoclonal Antibody Reveals Key Details Toward A Biodefense Vaccine And Diagnostics Against Melioidosis, Roberta Marchetti, Michael J. Dillon, Mary N. Burtnick, Mark A. Hubbard, Marielle Tamigney Kenfack, Yves Blériot, Charles Gauthier, Paul J. Brett, David P. Aucoin, Rosa Lanzetta, Alba Silipo, Antonio Molinaro Oct 2015

Burkholderia Pseudomallei Capsular Polysaccharide Recognition By A Monoclonal Antibody Reveals Key Details Toward A Biodefense Vaccine And Diagnostics Against Melioidosis, Roberta Marchetti, Michael J. Dillon, Mary N. Burtnick, Mark A. Hubbard, Marielle Tamigney Kenfack, Yves Blériot, Charles Gauthier, Paul J. Brett, David P. Aucoin, Rosa Lanzetta, Alba Silipo, Antonio Molinaro

Peninsula Medical School

No abstract provided.


From Within To Between, Ds Maranan Oct 2015

From Within To Between, Ds Maranan

School of Art, Design and Architecture

Somaesthetics is an approach advanced by Richard Shusterman (2000, 2006, 2008) in which bodily experience plays the central role in aesthetic appreciation, production, and analysis. Somaesthetics draws from a variety of epistemological approaches, including the philosophies of twentieth-century thinkers such as as Merleau-Ponty (1962), de Beauvoir (1997), Foucault (1986), and Wittgenstein; pragmatist philosophies of William James and John Dewey; and theoretical and practice-based contributions of somatic practitioners such as Moshe Feldenkrais and Frederick Alexander. It is an ameliorative approach that encourages heightened awareness of the body leading to an improved “use of the self” (Shusterman, 2008, p. 8). As a …


Igf-1r Inhibition Induces Schedule-Dependent Sensitization Of Melanoma To Temozolomide, R Ramcharan, T Aleksic, S Gao, Wp Kamdoum, Et Al Oct 2015

Igf-1r Inhibition Induces Schedule-Dependent Sensitization Of Melanoma To Temozolomide, R Ramcharan, T Aleksic, S Gao, Wp Kamdoum, Et Al

School of Biomedical Sciences

No abstract provided.


Characterisation, Quantity And Sorptive Properties Of Microplastics Extracted From Cosmetics, Imogen E. Napper, Adil Bakir, Steven J. Rowland, Richard C. Thompson Oct 2015

Characterisation, Quantity And Sorptive Properties Of Microplastics Extracted From Cosmetics, Imogen E. Napper, Adil Bakir, Steven J. Rowland, Richard C. Thompson

School of Geography, Earth and Environmental Sciences

Cosmetic products, such as facial scrubs, have been identified as potentially important primary sources of microplastics to the marine environment. This study characterises, quantifies and then investigates the sorptive properties of plastic microbeads that are used as exfoliants in cosmetics. Polyethylene microbeads were extracted from several products, and shown to have a wide size range (mean diameters between 164 and 327μm). We estimated that between 4594 and 94,500 microbeads could be released in a single use. To examine the potential for microbeads to accumulate and transport chemicals they were exposed to a binary mixture of 3H-phenanthrene and 14C-DDT …


Impact Of Ocean Acidification On Marine Organisms—Unifying Principles And New Paradigms, Jason M. Hall-Spencer, Mike Thorndyke, Sam Dupont Oct 2015

Impact Of Ocean Acidification On Marine Organisms—Unifying Principles And New Paradigms, Jason M. Hall-Spencer, Mike Thorndyke, Sam Dupont

School of Biological and Marine Sciences

No abstract provided.


Action Cameras: Bringing Aquatic And Fisheries Research Into View, Daniel P. Struthers, Andy J. Danylchuk, Alexander D.M. Wilson, Steven J. Cooke Oct 2015

Action Cameras: Bringing Aquatic And Fisheries Research Into View, Daniel P. Struthers, Andy J. Danylchuk, Alexander D.M. Wilson, Steven J. Cooke

School of Biological and Marine Sciences

Digital action cameras (ACs) are increasingly being utilized for aquatic research purposes due to their cost effectiveness, versatility, high-resolution imagery, and durability. Here we review the advantages of AC technology in research, with particular emphases on (a) research videography (both in the field and the laboratory), (b) animal-borne studies, and (c) outreach and education purposes. We also review some of the limitations of this technology as represented by environmental factors (e.g., depth, turbidity) and deployment considerations (e.g., lens choices, imaging settings, battery life). As AC technologies evolve in response to growing public interest in their application versatility, researchers are indirectly …


Pat4 Levels Control Amino-Acid Sensitivity Of Rapamycin-Resistant Mtorc1 From The Golgi And Affect Clinical Outcome In Colorectal Cancer, S-J Fan, C Snell, H Turley, J-L Li, Et Al Oct 2015

Pat4 Levels Control Amino-Acid Sensitivity Of Rapamycin-Resistant Mtorc1 From The Golgi And Affect Clinical Outcome In Colorectal Cancer, S-J Fan, C Snell, H Turley, J-L Li, Et Al

Peninsula Medical School

Tumour cells can use strategies that make them resistant to nutrient deprivation to outcompete their neighbours. A key integrator of the cell's responses to starvation and other stresses is amino-acid-dependent mechanistic target of rapamycin complex 1 (mTORC1). Activation of mTORC1 on late endosomes and lysosomes is facilitated by amino-acid transporters within the solute-linked carrier 36 (SLC36) and SLC38 families. Here, we analyse the functions of SLC36 family member, SLC36A4, otherwise known as proton-assisted amino-acid transporter 4 (PAT4), in colorectal cancer. We show that independent of other major pathological factors, high PAT4 expression is associated with reduced relapse-free survival after colorectal …


What Can Inactivity (In Its Various Forms) Reveal About Affective States In Non-Human Animals? A Review, C Fureix, Rk Meagher Oct 2015

What Can Inactivity (In Its Various Forms) Reveal About Affective States In Non-Human Animals? A Review, C Fureix, Rk Meagher

School of Biological and Marine Sciences

Captive/domestic animals are often described as inactive, with the implicit or explicit implication that this high level of inactivity is a welfare problem. Conversely, not being inactive enough may also indicate or cause poor welfare. In humans, too much inactivity can certainly be associated with either negative or positive affective states. In non-human animals, however, the affective states associated with elevated or suppressed levels of inactivity are still not well understood. Part of the complexity is due to the fact that there are many different forms of inactivity, each likely associated with very different affective states. This paper has two …