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Articles 3151 - 3180 of 6798
Full-Text Articles in Entire DC Network
The Decision To Move: Response Times, Neuronal Circuits And Sensory Memory In A Simple Vertebrate, A Roberts, R Borisyuk, E Buhl, A Ferrario, Et Al
The Decision To Move: Response Times, Neuronal Circuits And Sensory Memory In A Simple Vertebrate, A Roberts, R Borisyuk, E Buhl, A Ferrario, Et Al
School of Engineering, Computing and Mathematics
All animals use sensory systems to monitor external events and have to decide whether to move. Response times are long and variable compared to reflexes, and fast escape movements. The complexity of adult vertebrate brains makes it difficult to trace the neuronal circuits underlying basic decisions to move. To simplify the problem, we investigate the nervous system and responses of hatchling frog tadpoles which swim when their skin is stimulated. Studying the neuron-by-neuron pathway from sensory to hindbrain neurons, where the decision to swim is made, has revealed two simple pathways generating excitation which sums to threshold in these neurons …
Use Of Species Distribution Modeling In The Deep Sea, E Kenchington, O Callery, F Davidson, A Grehan, T Morato, J Appiott, A Davis, P Dunstan, Preez C Du, J Finney, Jm González-Irusta, K Howell, A Knudby, M Lacharité, J Lee, Fj Murillo, L Beazley, Jm Roberts, M Roberts, C Rooper, A Rowden, E Rubidge, R Stanley, D Stirling, Kr Tanaka, J Vanhatalo, B Weigel, S Woolley, C Yesson
Use Of Species Distribution Modeling In The Deep Sea, E Kenchington, O Callery, F Davidson, A Grehan, T Morato, J Appiott, A Davis, P Dunstan, Preez C Du, J Finney, Jm González-Irusta, K Howell, A Knudby, M Lacharité, J Lee, Fj Murillo, L Beazley, Jm Roberts, M Roberts, C Rooper, A Rowden, E Rubidge, R Stanley, D Stirling, Kr Tanaka, J Vanhatalo, B Weigel, S Woolley, C Yesson
School of Biological and Marine Sciences
No abstract provided.
The Lyme Bay Experimental Potting Study, A Rees
The Lyme Bay Experimental Potting Study, A Rees
School of Biological and Marine Sciences
No abstract provided.
Comprehensive Analysis Of Aspergillus Nidulans Pka Phosphorylome Identifies A Novel Mode Of Crea Regulation, Liliane F.C. Ribeiro, Cynthia Chelius, Karthik R. Boppidi, Nisha S. Naik, Simin Hossain, Jessica J.J. Ramsey, Jyothi Kumar, Lucas F. Ribeiro, Marc Ostermeier, Bao Tran, Young Ah Goo, Leandro J. Assis, Mevlut Ulas, Ozgur Bayram, Gustavo H. Goldman, Stephen Lincoln, Ranjan Srivastava, Steven D. Harris, Mark R. Martena
Comprehensive Analysis Of Aspergillus Nidulans Pka Phosphorylome Identifies A Novel Mode Of Crea Regulation, Liliane F.C. Ribeiro, Cynthia Chelius, Karthik R. Boppidi, Nisha S. Naik, Simin Hossain, Jessica J.J. Ramsey, Jyothi Kumar, Lucas F. Ribeiro, Marc Ostermeier, Bao Tran, Young Ah Goo, Leandro J. Assis, Mevlut Ulas, Ozgur Bayram, Gustavo H. Goldman, Stephen Lincoln, Ranjan Srivastava, Steven D. Harris, Mark R. Martena
Peninsula Medical School
In filamentous fungi, an important kinase responsible for adaptation to changes in available nutrients is cyclic AMP (cAMP)-dependent protein kinase (protein kinase A [PKA]). This kinase has been well characterized at a molecular level, but its systemic action and direct/indirect targets are generally not well understood in filamentous fungi. In this work, we used a pkaA deletion strain (ΔpkaA) to identify Aspergillus nidulans proteins for which phosphorylation is dependent (either directly or indirectly) on PKA. A combination of phosphoproteomic and transcriptomic analyses revealed both direct and indirect targets of PKA and provided a global perspective on its function. One of …
Mathematical Modelling Of Microtubule-Tau Protein Transients: Insights Into The Superior Mechanical Behavior Of Axon, L Li, Jiayu Wu
Mathematical Modelling Of Microtubule-Tau Protein Transients: Insights Into The Superior Mechanical Behavior Of Axon, L Li, Jiayu Wu
School of Engineering, Computing and Mathematics
No abstract provided.
Prediction Of Unprecedented Biological Shifts In The Global Ocean, G Beaugrand, A Conversi, A Atkinson, J Cloern, Et Al
Prediction Of Unprecedented Biological Shifts In The Global Ocean, G Beaugrand, A Conversi, A Atkinson, J Cloern, Et Al
School of Biological and Marine Sciences
Impermanence is an ecological principle 1 but there are times when changes occur nonlinearly as abrupt community shifts (ACSs) that transform the ecosystem state and the goods and services it provides 2 . Here, we present a model based on niche theory 3 to explain and predict ACSs at the global scale. We test our model using 14 multi-decadal time series of marine metazoans from zooplankton to fish, spanning all latitudes and the shelf to the open ocean. Predicted and observed fluctuations correspond, with both identifying ACSs at the end of the 1980s 4–7 and 1990s 5,8 . We show …
Gene Expression Meta-Analysis Of Parkinson's Disease And Its Relationship With Alzheimer's Disease, Jack Kelly, Rana Moyeed, Camille Carroll, Diego Albani, Xinzhong Li
Gene Expression Meta-Analysis Of Parkinson's Disease And Its Relationship With Alzheimer's Disease, Jack Kelly, Rana Moyeed, Camille Carroll, Diego Albani, Xinzhong Li
Peninsula Medical School
Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common neurodegenerative diseases and have been suggested to share common pathological and physiological links. Understanding the cross-talk between them could reveal potentials for the development of new strategies for early diagnosis and therapeutic intervention thus improving the quality of life of those affected. Here we have conducted a novel meta-analysis to identify differentially expressed genes (DEGs) in PD microarray datasets comprising 69 PD and 57 control brain samples which is the biggest cohort for such studies to date. Using identified DEGs, we performed pathway, upstream and protein-protein interaction analysis. We …
Phylogenomics Of The Superfamily Dytiscoidea (Coleoptera: Adephaga) With An Evaluation Of Phylogenetic Conflict And Systematic Error., Alexandros Vasilikopoulos, Michael Balke, Rolf G. Beutel, Alexander Donath, Lars Podsiadlowski, James M. Pflug, Robert M. Waterhouse, Karen Meusemann, Ralph S. Peters, Hermes E. Escalona, Christoph Mayer, Shanlin Liu, Lars Hendrich, Yves Alarie, David T. Bilton, Fenglong Jia, Xin Zhou, David R. Maddison, Oliver Niehuis, Bernhard Misof
Phylogenomics Of The Superfamily Dytiscoidea (Coleoptera: Adephaga) With An Evaluation Of Phylogenetic Conflict And Systematic Error., Alexandros Vasilikopoulos, Michael Balke, Rolf G. Beutel, Alexander Donath, Lars Podsiadlowski, James M. Pflug, Robert M. Waterhouse, Karen Meusemann, Ralph S. Peters, Hermes E. Escalona, Christoph Mayer, Shanlin Liu, Lars Hendrich, Yves Alarie, David T. Bilton, Fenglong Jia, Xin Zhou, David R. Maddison, Oliver Niehuis, Bernhard Misof
School of Biological and Marine Sciences
The beetle superfamily Dytiscoidea, placed within the suborder Adephaga, comprises six families. The phylogenetic relationships of these families, whose species are aquatic, remain highly contentious. In particular the monophyly of the geographically disjunct Aspidytidae (China and South Africa) remains unclear. Here we use a phylogenomic approach to demonstrate that Aspidytidae are indeed monophyletic, as we inferred this phylogenetic relationship from analyzing nucleotide sequence data filtered for compositional heterogeneity and from analyzing amino-acid sequence data. Our analyses suggest that Aspidytidae are the sister group of Amphizoidae, although the support for this relationship is not unequivocal. A sister group relationship of Hygrobiidae …
Differing Effects Of Age And Starvation On Reproductive Performance In Drosophila Melanogaster, Er Churchill, C Dytham, Mdf Thom
Differing Effects Of Age And Starvation On Reproductive Performance In Drosophila Melanogaster, Er Churchill, C Dytham, Mdf Thom
School of Biological and Marine Sciences
Successful reproduction requires the completion of many, often condition-dependent, stages, from mate searching and courtship through to sperm transfer, fertilisation and offspring production. Animals can plastically adjust their investment in each stage according to the physical and social environment, their own condition, their future reproductive potential, and the condition of their partner. Here we manipulate age and condition, through a nutritional challenge early or late in life, of both male and female Drosophila melanogaster and measure the effects on courtship, mating, and fitness when paired with a standardized (unmanipulated) partner. Older males were slower to start courting and mating, and …
Coastal Embayment Rotation: Response To Extreme Events And Climate Control, Using Full Embayment Surveys, Mark Wiggins, Tim Scott, Gerd Masselink, Paul Russell, Robert Jak Mccarroll
Coastal Embayment Rotation: Response To Extreme Events And Climate Control, Using Full Embayment Surveys, Mark Wiggins, Tim Scott, Gerd Masselink, Paul Russell, Robert Jak Mccarroll
School of Biological and Marine Sciences
© 2018 The Authors Barrier beach change in directionally bi-modal wave climates presents an increasing challenge for coastal communities, both in the short-term (storm events), and decadal to centurial time scales (long-term evolution). Predicting and planning for subsequent variations requires understanding of the morphological response to changes in wave energy, along with the atmospheric forces driving the wave climate. In this paper, multi-method topo-bathymetric surveys are used to assess the morphological change of a semi-sheltered gravel barrier (Start Bay, Devon, UK). Total sediment budgets (supra- to sub-tidal), with spatially-varying uncertainty levels, indicate the embayment is closed. One third of total …
Critical Dietetics And Sustainable Food Systems, L Carlsson, K Mehta, C Pettinger
Critical Dietetics And Sustainable Food Systems, L Carlsson, K Mehta, C Pettinger
School of Health Professions
No abstract provided.
Pollen-Inferred Regional Vegetation Patterns And Demographic Change In Southern Anatolia Through The Holocene, J Woodbridge, Cn Roberts, R Fyfe
Pollen-Inferred Regional Vegetation Patterns And Demographic Change In Southern Anatolia Through The Holocene, J Woodbridge, Cn Roberts, R Fyfe
More Faculty of Science and Engineering Research
No abstract provided.
Plankton Lifeforms As A Biodiversity Indicator For Regional-Scale Assessment Of Pelagic Habitats For Policy, Abigail Mcquatters-Gollop, Jacob Bedford
Plankton Lifeforms As A Biodiversity Indicator For Regional-Scale Assessment Of Pelagic Habitats For Policy, Abigail Mcquatters-Gollop, Jacob Bedford
School of Biological and Marine Sciences
No abstract provided.
What Motivates Academic Dishonesty In Students? A Reinforcement Sensitivity Theory Explanation., Alison M. Bacon, Chloe Mcdaid, Natasha Williams, Philip J. Corr
What Motivates Academic Dishonesty In Students? A Reinforcement Sensitivity Theory Explanation., Alison M. Bacon, Chloe Mcdaid, Natasha Williams, Philip J. Corr
School of Psychology
No abstract provided.
Physical And Numerical Modeling Of Infragravity Wave Generation And Transformation On Coral Reef Platforms, Gerd Masselink, Megan Tuck, Robert Mccall, Dongeren A Van, Murray Ford, Paul Kench
Physical And Numerical Modeling Of Infragravity Wave Generation And Transformation On Coral Reef Platforms, Gerd Masselink, Megan Tuck, Robert Mccall, Dongeren A Van, Murray Ford, Paul Kench
School of Biological and Marine Sciences
©2019. American Geophysical Union. All Rights Reserved. Wave transformation across reef platforms strongly controls sediment transport processes and coral reef island morphodynamics with infragravity (IG) waves playing an important contributing role. A small-scale (1:50) laboratory experiment and prototype numerical modeling are used to explore the characteristics of IG wave motion on coral reefs. The slope of the fore reef is the key factor controlling the mechanism of IG wave generation. Steep slopes (>1/10) are dominated by landward and seaward propagating breakpoint-forced long waves, whereas incoming and then released bound long waves become increasingly important for slopes <1/20. The breakpoint-forced long wave mechanism is the more effective generator of IG energy, and the most energetic IG motion (normalized by incident wave motion) is generated on reef platforms with a fore reef slope > 1/6. The water …
Seasonal Variation Of Contaminant Concentrations In Wastewater Treatment Works Effluents And River Waters., S. D.W. Comber, M. J. Gardner, B. Ellor
Seasonal Variation Of Contaminant Concentrations In Wastewater Treatment Works Effluents And River Waters., S. D.W. Comber, M. J. Gardner, B. Ellor
School of Geography, Earth and Environmental Sciences
Results are presented for 170 wastewater treatment works sites (20 per substance in influent, effluent and 36 per substance in river water upstream and downstream of the WwTW discharge) over a period of two years between 2015 and 2017; this comprises data for approximately 3000 samples for effluent and 6000 for river samples taken downstream of effluent discharges. Seasonal trends in contaminant concentrations for several substances are reported. Two clear patterns of seasonal variation are proposed over and above all of the variables associated with environmental data including process technology, dilution and geography. Firstly, variation of riverine concentrations caused by …
The Changing Face Of The Mediterranean–Land Cover, Demography And Environmental Change: Introduction And Overview, Andrew Bevan, Alessio Palmisano, Jessie Woodbridge, Ralph Fyfe, Neil Roberts, Stephen Shennan
The Changing Face Of The Mediterranean–Land Cover, Demography And Environmental Change: Introduction And Overview, Andrew Bevan, Alessio Palmisano, Jessie Woodbridge, Ralph Fyfe, Neil Roberts, Stephen Shennan
School of Geography, Earth and Environmental Sciences
This paper introduces a special issue on The Changing Face of the Mediterranean: Land Cover, Demography, and Environmental Change, which brings together up-to-date regional or thematic perspectives on major long-term trends in Mediterranean human–environment relations. Particularly, important insights are provided by palynology to reconstruct past vegetation and land cover, and archaeology to establish long-term demographic trends, but with further significant input from palaeoclimatology, palaeofire research and geomorphology. Here, we introduce the rationale behind this pan-Mediterranean research initiative, outline its major sources of evidence and method, and describe how individual submissions work to complement one another.
Autoxidation Of The Sea Ice Biomarker Proxy Ipso 25 In The Near-Surface Oxic Layers Of Arctic And Antarctic Sediments, Jean François Rontani, Lukas Smik, Simon T. Belt
Autoxidation Of The Sea Ice Biomarker Proxy Ipso 25 In The Near-Surface Oxic Layers Of Arctic And Antarctic Sediments, Jean François Rontani, Lukas Smik, Simon T. Belt
School of Geography, Earth and Environmental Sciences
© 2019 Over the last decade or so, the mono- and di-unsaturated highly branched isoprenoid (HBI) lipids IP 25 (Ice Proxy with 25 carbon atoms) and IPSO 25 (Ice Proxy for the Southern Ocean with 25 carbon atoms) have emerged as useful proxies for sea ice in the Arctic and Antarctic, respectively. A more complete understanding of their respective proxy signatures, however, requires more detailed knowledge of their stability in the water column and in sediments. In the current study, we focused on the autoxidation of IPSO 25 , first by performing laboratory-based oxidation reactions on a purified sample and …
Strengthened Scientific Support For The Endangerment Finding For Atmospheric Greenhouse Gases, Pb Duffy, Cb Field, Ns Diffenbaugh, Sc Doney, Et Al
Strengthened Scientific Support For The Endangerment Finding For Atmospheric Greenhouse Gases, Pb Duffy, Cb Field, Ns Diffenbaugh, Sc Doney, Et Al
School of Biological and Marine Sciences
We assess scientific evidence that has emerged since the U.S. Environmental Protection Agency’s 2009 Endangerment Finding for six well-mixed greenhouse gases and find that this new evidence lends increased support to the conclusion that these gases pose a danger to public health and welfare. Newly available evidence about a wide range of observed and projected impacts strengthens the association between the risk of some of these impacts and anthropogenic climate change, indicates that some impacts or combinations of impacts have the potential to be more severe than previously understood, and identifies substantial risk of additional impacts through processes and pathways …
The Effect Of Feeding A Novel Multistrain Yeast Fraction On European Seabass (Dicentrachus Labrax) Intestinal Health And Growth Performance, Mark D. Rawling, Nicola Pontefract, Ana Rodiles, Ilektra Anagnostara, Eric Leclercq, Marion Schiavone, Mathieu Castex, Daniel L. Merrifield
The Effect Of Feeding A Novel Multistrain Yeast Fraction On European Seabass (Dicentrachus Labrax) Intestinal Health And Growth Performance, Mark D. Rawling, Nicola Pontefract, Ana Rodiles, Ilektra Anagnostara, Eric Leclercq, Marion Schiavone, Mathieu Castex, Daniel L. Merrifield
School of Biological and Marine Sciences
© Copyright by the World Aquaculture Society 2019 Fish were fed a single-strain yeast fraction (SsYF; 2 g/kg) or a multistrain yeast fraction (MsYF; 0.8 g/kg) for 10 weeks. The results demonstrated significant (p ≤ 0.03) elevations in weight gain, specific growth rate, protein efficiency ratio, and feed conversion ratio in fish fed the yeast fraction-supplemented diets. In the distal intestine, a significant elevation in microvilli density was observed after 5 and 10 weeks of dietary supplementation with MsYF and SsYF, respectively, compared to control fed fish (p < 0.001). A significant elevation (p = 0.02) in the perimeter ratio was observed in fish fed diets supplemented with the yeast fractions. After 10 weeks of feeding on the experimental diets, Rt-qPCR demonstrated a significant downregulation (p < 0.05) in the stress response genes, heat-shock protein 70 (hsp70) and proliferating cell nuclear antigen (pcna), in fish fed diets supplemented with the yeast fractions. Significant (p < 0.05) elevations in interleukin 1-beta (il1β) and interleukin-10 (il10) gene expression were observed in fish fed diets supplemented with the MsYF compared to the other dietary groups. These findings suggest that feeding an MsYF specifically at a lower incorporation rate < 1 g/kg, compared to a commercial SsYF at 2 g/kg, is effective in improving the intestinal health status and growth performance of European seabass.
Tackling The Lionfish Invasion In The Mediterranean. The Eu-Life Relionmed Project: Progress And Results, P Kleitou, J Hall-Spencer, S Rees, S Sfenthourakis, A Demetriou, N Chartosia, C Jimenez, L Hadjioannou, A Petrou, Y Christodoulides, A Georgiou, V Andreou, C Antoniou, I Savva, D Kletou
Tackling The Lionfish Invasion In The Mediterranean. The Eu-Life Relionmed Project: Progress And Results, P Kleitou, J Hall-Spencer, S Rees, S Sfenthourakis, A Demetriou, N Chartosia, C Jimenez, L Hadjioannou, A Petrou, Y Christodoulides, A Georgiou, V Andreou, C Antoniou, I Savva, D Kletou
School of Biological and Marine Sciences
No abstract provided.
Re-Evaluation Of The Ethylene-Dependent And -Independent Pathways In The Regulation Of Floral And Organ Abscission, S Meir, S Philosoph-Hadas, J Riov, Et Al
Re-Evaluation Of The Ethylene-Dependent And -Independent Pathways In The Regulation Of Floral And Organ Abscission, S Meir, S Philosoph-Hadas, J Riov, Et Al
School of Geography, Earth and Environmental Sciences
Abscission is a developmental process with important implications for agricultural practices. Ethylene has long been considered as a key regulator of the abscission process. The existence of an ethylene-independent abscission pathway, controlled by the complex of INFLORESCENCE DEFICIENT IN ABSCISSION (IDA) peptide and the HAESA (HAE) and HAESA-like2 (HSL2) kinases, has been proposed, based mainly on observations that organ abscission in ethylene-insensitive mutants was delayed but not inhibited. A recent review on plant organ abscission signaling highlighted the IDA-HAE-HSL2 components as the regulators of organ abscission, while the role of auxin and ethylene in this process was hardly addressed. After …
Correction: Popular Interest In Vertebrates Does Not Reflect Extinction Risk And Is Associated With Bias In Conservation Investment, Thomas Davies, Andrew Cowley, Jon Bennie, Catherine Leyshon, Richard Inger, Hazel Carter, Beth Robinson, James P. Duffy, Stefano Casalegno, Gwladys Lambert, Kevin Gaston
Correction: Popular Interest In Vertebrates Does Not Reflect Extinction Risk And Is Associated With Bias In Conservation Investment, Thomas Davies, Andrew Cowley, Jon Bennie, Catherine Leyshon, Richard Inger, Hazel Carter, Beth Robinson, James P. Duffy, Stefano Casalegno, Gwladys Lambert, Kevin Gaston
School of Biological and Marine Sciences
No abstract provided.
Identification And Functional Characterization Of A Novel Fc Gamma-Binding Glycoprotein In Rhesus Cytomegalovirus, Philipp Kolb, Steven Sijmons, Matthew R. Mcardle, Husam Taher, Jennie Womack, Colette Hughes, Abigail Ventura, Michael A. Jarvis, Christiane Stahl-Hennig, Scott Hansen, Louis J. Picker, Daniel Malouli, Hartmut Hengel, Klaus Früh
Identification And Functional Characterization Of A Novel Fc Gamma-Binding Glycoprotein In Rhesus Cytomegalovirus, Philipp Kolb, Steven Sijmons, Matthew R. Mcardle, Husam Taher, Jennie Womack, Colette Hughes, Abigail Ventura, Michael A. Jarvis, Christiane Stahl-Hennig, Scott Hansen, Louis J. Picker, Daniel Malouli, Hartmut Hengel, Klaus Früh
School of Biomedical Sciences
Receptors recognizing the Fc part of immunoglobulin G (FcγRs) are key determinants in antibody-mediated immune responses. Members of the Herpesviridae interfere with this immune regulatory network by expressing viral FcγRs (vFcγRs). Human cytomegalovirus (HCMV) encodes four distinct vFcγRs that differ with respect to their IgG-subtype specificity and their impact on antibody-mediated immune function in vitro The impact of vFcγRs on HCMV pathogenesis and immunomodulation in vivo is not known. The evolutionary closest animal model of HCMV is rhesus CMV (RhCMV) infection of rhesus macaques. To enable the characterization of vFcγR function in this model, we studied IgG binding by RhCMV. …
‘Salting’: Preserving, Seasoning, Savouring, Purifying And Transforming Through ‘Marine Adventuring’, Journal Of Adventure Education And Outdoor Learning, Alun D. Morgan
Plymouth Institute of Education
No abstract provided.
Are We Speaking The Same Language? Recommendations For A Definition And Categorization Framework For Plastic Debris, Nanna B. Hartmann, Thorsten Hüffer, Richard C. Thompson, Martin Hassellöv, Anja Verschoor, Anders E. Daugaard, Sinja Rist, Therese Karlsson, Nicole Brennholt, Matthew Cole, Maria P. Herrling, Maren C. Hess, Natalia P. Ivleva, Amy L. Lusher, Martin Wagner
Are We Speaking The Same Language? Recommendations For A Definition And Categorization Framework For Plastic Debris, Nanna B. Hartmann, Thorsten Hüffer, Richard C. Thompson, Martin Hassellöv, Anja Verschoor, Anders E. Daugaard, Sinja Rist, Therese Karlsson, Nicole Brennholt, Matthew Cole, Maria P. Herrling, Maren C. Hess, Natalia P. Ivleva, Amy L. Lusher, Martin Wagner
School of Biological and Marine Sciences
The accumulation of plastic litter in natural environments is a global issue. Concerns over potential negative impacts on the economy, wildlife, and human health provide strong incentives for improving the sustainable use of plastics. Despite the many voices raised on the issue, we lack a consensus on how to define and categorize plastic debris. This is evident for microplastics, where inconsistent size classes are used and where the materials to be included are under debate. While this is inherent in an emerging research field, an ambiguous terminology results in confusion and miscommunication that may compromise progress in research and mitigation …
A Variant In The Mica Gene Is Associated With Liver Fibrosis Progression In Chronic Hepatitis C Through Tgf-Β1 Dependent Mechanisms., Rasha El Sharkawy, Ali Bayoumi, Mayada Metwally, Alessandra Mangia, Thomas Berg, Manuel Romero-Gomez, Maria Lorena Abate, William L. Irving, David Sheridan, Gregory J. Dore, Ulrich Spengler, Pietro Lampertico, Elisabetta Bugianesi, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Rosanna Santoro, Rocío Gallego-Durán, Janett Fischer, Jacob Nattermann, R D'Ambrosio, Duncan Mcleod, Elizabeth Powell, Olivier Latchoumanin, Khaled Thabet, Mustafa A.M. Najim, Mark W. Douglas, Christopher Liddle, Christopher Liddle, Jacob George, Mohammed Eslam, Liver Disease Genetics Consortium (Ildgc) International
A Variant In The Mica Gene Is Associated With Liver Fibrosis Progression In Chronic Hepatitis C Through Tgf-Β1 Dependent Mechanisms., Rasha El Sharkawy, Ali Bayoumi, Mayada Metwally, Alessandra Mangia, Thomas Berg, Manuel Romero-Gomez, Maria Lorena Abate, William L. Irving, David Sheridan, Gregory J. Dore, Ulrich Spengler, Pietro Lampertico, Elisabetta Bugianesi, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Rosanna Santoro, Rocío Gallego-Durán, Janett Fischer, Jacob Nattermann, R D'Ambrosio, Duncan Mcleod, Elizabeth Powell, Olivier Latchoumanin, Khaled Thabet, Mustafa A.M. Najim, Mark W. Douglas, Christopher Liddle, Christopher Liddle, Jacob George, Mohammed Eslam, Liver Disease Genetics Consortium (Ildgc) International
Peninsula Medical School
Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients. The role of these variants on hepatic inflammation and fibrosis that are closely associated with HCC development is not known, nor are the biological mechanisms underlying their impact on the liver. Here, we demonstrate in 1689 patients with chronic hepatitis C (CHC) (1,501 with CHC and 188 with HCV-related HCC), that the MICA (T) allele, despite not being associated with HCC susceptibility, is associated with increased fibrosis stage …
Proteomic Study Uncovers Molecular Principles Of Single-Cell-Level Phenotypic Heterogeneity In Lipid Storage Of Nannochloropsis Oceanica, C Chen, A Harst, W You, Et Al
Proteomic Study Uncovers Molecular Principles Of Single-Cell-Level Phenotypic Heterogeneity In Lipid Storage Of Nannochloropsis Oceanica, C Chen, A Harst, W You, Et Al
School of Biomedical Sciences
Background Nannochloropsis oceanica belongs to a large group of photoautotrophic eukaryotic organisms that play important roles in fixation and cycling of atmospheric CO2. Its capability of storing solar energy and carbon dioxide in the form of triacylglycerol (TAG) of up to 60% of total weight under nitrogen deprivation stress sparked interest in its use for biofuel production. Phenotypes varying in lipid accumulation among an N. oceanica population can be disclosed by single-cell analysis/sorting using fluorescence-activated cell sorting (FACS); yet the phenomenon of single cell heterogeneity in an algae population remains to be fully understood at the molecular level. In this …
Size-Selective Harvesting And Individual Personality In A Social Fish, V Sbragaglia, J Alós, K Fromm, C Monk, C Díaz-Gil, S Uusi-Heikkilä, A Honsey, A Wilson, R Arlinghaus
Size-Selective Harvesting And Individual Personality In A Social Fish, V Sbragaglia, J Alós, K Fromm, C Monk, C Díaz-Gil, S Uusi-Heikkilä, A Honsey, A Wilson, R Arlinghaus
School of Biological and Marine Sciences
No abstract provided.
Rn181 Is A Tumour Suppressor In Gastric Cancer By Regulation Of The Erk/Mapk–Cyclin D1/Cdk4 Pathway, S Wang, X Wang, Y Gao, Y Peng, Et Al
Rn181 Is A Tumour Suppressor In Gastric Cancer By Regulation Of The Erk/Mapk–Cyclin D1/Cdk4 Pathway, S Wang, X Wang, Y Gao, Y Peng, Et Al
Peninsula Medical School
RN181, a RING finger domain-containing protein, is an E3 ubiquitin ligase. However, its biological function and clinical significance in cancer biology are obscure. Here, we report that RN181 expression is significantly down-regulated in 165 tumour tissues of gastric carcinoma (GC) versus adjacent non-tumour tissues, and inversely associated with tumour differentiation, tumour size, clinical stage, and patient's overall survival. Alterations of RN181 expression in GC cells by retrovirus-transduced up-regulation and down-regulation demonstrated that RN181 functions as a tumour suppressor to inhibit growth of GC in both in vitro culture and in vivo animal models by decreasing tumour cell proliferation and increasing …