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Articles 2521 - 2550 of 6795
Full-Text Articles in Entire DC Network
Impacts Of Microplastic Fibres On The Marine Mussel, Mytilus Galloprovinciallis, Nashami Alnajar, Awadhesh N. Jha, Andrew Turner
Impacts Of Microplastic Fibres On The Marine Mussel, Mytilus Galloprovinciallis, Nashami Alnajar, Awadhesh N. Jha, Andrew Turner
School of Biological and Marine Sciences
No abstract provided.
Choice Of Molecular Assay Determines Ranavirus Detection Probability And Inferences About Prevalence And Occurrence, Felicity J. Wynne, Robert Puschendorf, Mairi E. Knight, Stephen J. Price
Choice Of Molecular Assay Determines Ranavirus Detection Probability And Inferences About Prevalence And Occurrence, Felicity J. Wynne, Robert Puschendorf, Mairi E. Knight, Stephen J. Price
School of Biological and Marine Sciences
Ranaviruses are emerging pathogens that can cause morbidity, mortality and population declines in ectothermic hosts; however, there is no standardized approach to diagnostics. Here, we compared the inter-assay variation and intra-assay precision among 2 commonly used quantitative PCRs (qPCRs), a conventional and a nested PCR assay (used as a gold standard), using laboratory-propagated ranavirus (FV3 and CMTV) and field-collected samples. A qPCR assay (‘Leung’) detected viral DNA in dilutions 2 orders of magnitude lower than other assays regardless of the viral lineage of the cultured isolate (FV3/CMTV). The second qPCR (‘Brunner’) was slightly more sensitive than the conventional PCR (‘Mao’ …
Bayesian Estimation Of Lassa Virus Epidemiological Parameters: Implications For Spillover Prevention Using Wildlife Vaccination, Scott L. Nuismer, Christopher H. Remien, Andrew J. Basinski, Tanner Varrelman, Nathan Layman, Kyle Rosenke, Brian Bird, Michael Jarvis, Peter Barry, Patrick W. Hanley, Elisabeth Fichet-Calvet
Bayesian Estimation Of Lassa Virus Epidemiological Parameters: Implications For Spillover Prevention Using Wildlife Vaccination, Scott L. Nuismer, Christopher H. Remien, Andrew J. Basinski, Tanner Varrelman, Nathan Layman, Kyle Rosenke, Brian Bird, Michael Jarvis, Peter Barry, Patrick W. Hanley, Elisabeth Fichet-Calvet
School of Biomedical Sciences
No abstract provided.
Evaluating Scenarios Toward Zero Plastic Pollution, Winnie W.Y. Lau, Yonathan Shiran, Richard M. Bailey, Ed Cook, Martin R. Stuchtey, Julia Koskella, Costas A. Velis, Linda Godfrey, Julien Boucher, Margaret B. Murphy, Richard C. Thompson, Emilia Jankowska, Arturo Castillo Castillo, Toby D. Pilditch, Ben Dixon, Laura Koerselman, Edward Kosior, Enzo Favoino, Jutta Gutberlet, Sarah Baulch, Meera E. Atreya, David Fischer, Kevin K. He, Milan M. Petit, U. Rashid Sumaila, Emily Neil, Mark V. Bernhofen, Keith Lawrence, James E. Palardy
Evaluating Scenarios Toward Zero Plastic Pollution, Winnie W.Y. Lau, Yonathan Shiran, Richard M. Bailey, Ed Cook, Martin R. Stuchtey, Julia Koskella, Costas A. Velis, Linda Godfrey, Julien Boucher, Margaret B. Murphy, Richard C. Thompson, Emilia Jankowska, Arturo Castillo Castillo, Toby D. Pilditch, Ben Dixon, Laura Koerselman, Edward Kosior, Enzo Favoino, Jutta Gutberlet, Sarah Baulch, Meera E. Atreya, David Fischer, Kevin K. He, Milan M. Petit, U. Rashid Sumaila, Emily Neil, Mark V. Bernhofen, Keith Lawrence, James E. Palardy
School of Biological and Marine Sciences
Plastic pollution is a pervasive and growing problem. To estimate the effectiveness of interventions to reduce plastic pollution, we modeled stocks and flows of municipal solid waste and four sources of microplastics through the global plastic system for five scenarios between 2016 and 2040. Implementing all feasible interventions reduced plastic pollution by 40% from 2016 rates and 78% relative to “business as usual” in 2040. Even with immediate and concerted action, 710 million metric tons of plastic waste cumulatively entered aquatic and terrestrial ecosystems. To avoid a massive build-up of plastic in the environment, coordinated global action is urgently needed …
Seagrass Of Vasiliko Bay, Eastern Mediterranean: Lost Cause Or Priority Conservation Habitat?, Demetris Kletou, Periklis Kleitou, Ioannis Savva, Martin J. Attrill, Stephanos Charalambous, Alexis Loucaides, Jason M. Hall-Spencer
Seagrass Of Vasiliko Bay, Eastern Mediterranean: Lost Cause Or Priority Conservation Habitat?, Demetris Kletou, Periklis Kleitou, Ioannis Savva, Martin J. Attrill, Stephanos Charalambous, Alexis Loucaides, Jason M. Hall-Spencer
School of Biological and Marine Sciences
Mediterranean coasts are affected by multiple mounting pressures. In Cyprus, marine fish farming has grown rapidly in the past decade and is concentrated in the west side of Vasiliko Bay. The east coast of this bay has ports, a power station, a desalination unit, a cement factory, a major new oil terminal, and gas storage facilities. The bay is earmarked to create the largest hydrocarbon processing, storing, and transport facility in the region. Here, we assess the status of Posidonia oceanica habitat in an understudied region at the upper thermal, and eastern limit, of this Mediterranean endemic seagrass. An extensive …
Consequences Of Surface Coatings And Soil Ageing On The Toxicity Of Cadmium Telluride Quantum Dots To The Earthworm Eisenia Fetida, K Tatsi, Th Hutchinson, Rd Handy
Consequences Of Surface Coatings And Soil Ageing On The Toxicity Of Cadmium Telluride Quantum Dots To The Earthworm Eisenia Fetida, K Tatsi, Th Hutchinson, Rd Handy
School of Geography, Earth and Environmental Sciences
No abstract provided.
Plasmodium Berghei Laps Form An Extended Protein Complex That Facilitates Crystalloid Targeting And Biogenesis, Annie Z. Tremp, Sadia Saeed, Vikram Sharma, Edwin Lasonder, Johannes T. Dessens
Plasmodium Berghei Laps Form An Extended Protein Complex That Facilitates Crystalloid Targeting And Biogenesis, Annie Z. Tremp, Sadia Saeed, Vikram Sharma, Edwin Lasonder, Johannes T. Dessens
School of Biomedical Sciences
No abstract provided.
An Ethnographic Study Of Palliative And End-Of-Life Care In A Nigerian Hospital: Impact Of Education On Care Provision And Utilization, David A. Agom, Tonia C. Onyeka, Jude Ominyi, Judith Sixsmith, Sarah Neill, Stuart Allen, Helen Poole
An Ethnographic Study Of Palliative And End-Of-Life Care In A Nigerian Hospital: Impact Of Education On Care Provision And Utilization, David A. Agom, Tonia C. Onyeka, Jude Ominyi, Judith Sixsmith, Sarah Neill, Stuart Allen, Helen Poole
School of Nursing and Midwifery
Most clinicians receive little or no palliative care (PC) education. Similarly, patients and their families receive little or no information on PC. Our study explored education in PC, while examining for its impacts on service delivery and utilization from the perspective of health care professionals (HCPs), patients, and their families. An ethnographic approach was utilized to gather data from 41 participants. Spradley’s ethnographic analytical framework guided data analysis. Two themes identified were inadequate HCPs’ knowledge base and impact of service-users’ inadequate health education. The findings show that most HCPs had no formal education in PC, attributed to the lack of …
Characterising Life In Settlements And Structures: Incorporating Faecal Lipid Biomarkers Within A Multiproxy Case Study Of A Wetland Village, H Mackay, Kl Davies, J Robertson, L Roy, Et Al
Characterising Life In Settlements And Structures: Incorporating Faecal Lipid Biomarkers Within A Multiproxy Case Study Of A Wetland Village, H Mackay, Kl Davies, J Robertson, L Roy, Et Al
School of Geography, Earth and Environmental Sciences
Roundhouses are ubiquitous features of Iron Age landscapes across North West Europe, yet the way they were used internally is not well understood. We demonstrate how spatial analyses of steroid lipid biomarkers advances our understanding of household activities, living conditions and animal management associated with a well-preserved 5th century BCE roundhouse from Scotland's first Iron Age wetland village, Black Loch of Myrton, especially when combined with more traditional archaeological approaches. Faecal steroids (5ß-stanols and bile acids) are well preserved within the wetland roundhouse floor deposits. Diffuse faecal inputs are identified within these deposits, limiting the resolution of faecal source discrimination …
Foamed Polystyrene In The Marine Environment: Sources, Additives, Transport, Behavior, And Impacts, Andrew Turner
Foamed Polystyrene In The Marine Environment: Sources, Additives, Transport, Behavior, And Impacts, Andrew Turner
School of Geography, Earth and Environmental Sciences
No abstract provided.
Dietary Bioaccumulation Potential Of Silver Nanomaterials Compared To Silver Nitrate In Wistar Rats Using An Ex Vivo Gut Sac Technique, Nathaniel J. Clark, Waldemar Woznica, Richard D. Handy
Dietary Bioaccumulation Potential Of Silver Nanomaterials Compared To Silver Nitrate In Wistar Rats Using An Ex Vivo Gut Sac Technique, Nathaniel J. Clark, Waldemar Woznica, Richard D. Handy
School of Health Professions
No abstract provided.
Mobilisation Kinetics Of Br, Cd, Cr, Hg, Pb And Sb In Microplastics Exposed To Simulated, Dietary-Adapted Digestive Conditions Of Seabirds, Elliot C. Smith, Andrew Turner
Mobilisation Kinetics Of Br, Cd, Cr, Hg, Pb And Sb In Microplastics Exposed To Simulated, Dietary-Adapted Digestive Conditions Of Seabirds, Elliot C. Smith, Andrew Turner
School of Geography, Earth and Environmental Sciences
No abstract provided.
Greening Of Grey Infrastructure Should Not Be Used As A Trojan Horse To Facilitate Coastal Development, Louise B. Firth, Laura Airoldi, Fabio Bulleri, Steve Challinor, Su Yin Chee, Ally J. Evans, Mick E. Hanley, Antony M. Knights, Kathryn O'Shaughnessy, Richard C. Thompson, Stephen J. Hawkins
Greening Of Grey Infrastructure Should Not Be Used As A Trojan Horse To Facilitate Coastal Development, Louise B. Firth, Laura Airoldi, Fabio Bulleri, Steve Challinor, Su Yin Chee, Ally J. Evans, Mick E. Hanley, Antony M. Knights, Kathryn O'Shaughnessy, Richard C. Thompson, Stephen J. Hawkins
School of Biological and Marine Sciences
Climate change and coastal urbanization are driving the replacement of natural habitats with artificial structures and reclaimed land globally. These novel habitats are often poor surrogates for natural habitats. The application of integrated greening of grey infrastructure (IGGI) to artificial shorelines demonstrates how multifunctional structures can provide biodiversity benefits whilst simultaneously serving their primary engineering function. IGGI is being embraced globally, despite many knowledge gaps and limitations. It is a management tool to compensate anthropogenic impacts as part of the Mitigation Hierarchy. There is considerable scope for misuse and ‘greenwashing’ however, by making new developments appear more acceptable, thus facilitating …
Contributions Of Fat And Carbohydrate Metabolism To Glucose Homeostasis In Childhood Change With Age And Puberty: A 12-Years Cohort Study (Earlybird 77), Ornella Cominetti, Joanne Hosking, Alison Jeffery, Jonathan Pinkney, Francois Pierre Martin
Contributions Of Fat And Carbohydrate Metabolism To Glucose Homeostasis In Childhood Change With Age And Puberty: A 12-Years Cohort Study (Earlybird 77), Ornella Cominetti, Joanne Hosking, Alison Jeffery, Jonathan Pinkney, Francois Pierre Martin
Peninsula Medical School
No abstract provided.
The Impact Of Knowledge Governance Mechanisms On Supply Chain Performance: Empirical Evidence From The Agri-Food Industry, Guoqing Zhao, Shaofeng Liu, H Chen, Dulekha Kasturiratne
The Impact Of Knowledge Governance Mechanisms On Supply Chain Performance: Empirical Evidence From The Agri-Food Industry, Guoqing Zhao, Shaofeng Liu, H Chen, Dulekha Kasturiratne
Plymouth Business School
No abstract provided.
Self-Limiting Versus Rotary Subjective Carious Tissue Removal: A Randomized Controlled Clinical Trial—2-Year Results, Ah Ali, Fb Thani, F Foschi, A Banerjee, F Mannocci
Self-Limiting Versus Rotary Subjective Carious Tissue Removal: A Randomized Controlled Clinical Trial—2-Year Results, Ah Ali, Fb Thani, F Foschi, A Banerjee, F Mannocci
Peninsula Dental School
Background: the aim of this study was to assess the 2-year pulp survival of deep carious lesions in teeth excavated using a self-limiting protocol in a single-blind randomized controlled clinical trial. Methods: At baseline, 101 teeth with deep carious lesions in 86 patients were excavated randomly using self-limiting or control protocols. Standardized clinical examination and periapical radiographs of teeth were performed after 1- and 2-year follow-ups (REC 14/LO/0880). Results: During the 2-year period of the study, 24 teeth failed (16 and 8 at T12 and T24, respectively). Final analysis shows that 39/63 (61.9%) of teeth were deemed successful (16/33 (48.4%) …
The High Osmolarity Glycerol Mitogen-Activated Protein Kinase Regulates Glucose Catabolite Repression In Filamentous Fungi, Leandro Jose De Assis, G. H. Goldman, Lilian Pereira Silva, Oliver Valerius, Gerhard H. Braus, Laure Ries, Kerstin Schmitt, Gh Goldman
The High Osmolarity Glycerol Mitogen-Activated Protein Kinase Regulates Glucose Catabolite Repression In Filamentous Fungi, Leandro Jose De Assis, G. H. Goldman, Lilian Pereira Silva, Oliver Valerius, Gerhard H. Braus, Laure Ries, Kerstin Schmitt, Gh Goldman
School of Biomedical Sciences
No abstract provided.
The Pandemic Push: Can Covid-19 Reinvent Conferences To Models Rooted In Sustainability, Equitability And Inclusion?, Holly J. Niner, Shaili Johri, Judith Meyer, Sophia N. Wassermann
The Pandemic Push: Can Covid-19 Reinvent Conferences To Models Rooted In Sustainability, Equitability And Inclusion?, Holly J. Niner, Shaili Johri, Judith Meyer, Sophia N. Wassermann
School of Biological and Marine Sciences
AbstractThe COVID-19 pandemic necessitates a change in conference formats for 2020. This shift offers a unique opportunity to address long-standing inequities in access and issues of sustainability associated with traditional conference formats, through testing online platforms. However, moving online is not a panacea for all of these concerns, particularly those arising from uneven distribution of access to the Internet and other technology. With conferences and events being forced to move online, this is a critical juncture to examine how online formats can be used to best effect and to reduce the inequities of in-person meetings. In this article, we highlight …
Antimicrobial Effectiveness Of Calcium Silicate Sealers Against A Nutrient-Stressed Multispecies Biofilm, R Bose, K Ioannidis, F Foschi, A Bakhsh, Rd Kelly, S Deb, F Mannocci, Sa Niazi
Antimicrobial Effectiveness Of Calcium Silicate Sealers Against A Nutrient-Stressed Multispecies Biofilm, R Bose, K Ioannidis, F Foschi, A Bakhsh, Rd Kelly, S Deb, F Mannocci, Sa Niazi
Peninsula Dental School
Purpose: This study compared the antimicrobial efficacy of calcium silicate sealers (BioRoot RCS and Total Fill BC) and conventional sealers (AH Plus and Tubli-seal) against planktonic bacteria and a nutrient-stressed multispecies biofilm. Methods: Antimicrobial properties of freshly mixed sealers were investigated using the direct contact test (DCT) and a nutrient-stressed multispecies biofilm comprised of five endodontic strains. Antimicrobial activity was determined using quantitative viable counts and confocal laser scanning microscopy (CLSM) analysis with live/dead staining. The pH of the sealers was analysed over a period of 28 days in Hanks Balanced Salt Solution (HBSS). Analysis of variance (ANOVA) with Tukey …
Taxonomic Revision Of The Afrotropical Agabus Raffrayi Species Group With The Description Of Four New Species (Coleoptera, Dytiscidae), William F. Englund, Laban Njoroge, Olof Biström, Kelly B. Miller, David T. Bilton, Johannes Bergsten
Taxonomic Revision Of The Afrotropical Agabus Raffrayi Species Group With The Description Of Four New Species (Coleoptera, Dytiscidae), William F. Englund, Laban Njoroge, Olof Biström, Kelly B. Miller, David T. Bilton, Johannes Bergsten
School of Biological and Marine Sciences
We revise the Afrotropical Agabus raffrayi species group, motivated by the discovery of new diversity in Kenya and South Africa. Whilst Agabus is mainly a holarctic genus, the Agabus raffrayi group is restricted to high altitude regions of eastern Africa and temperate parts of South Africa, from where we describe the southernmost Agabus in the world. The following new species are introduced: Agabus anguluverpus sp. nov. from Mount Kenya in central Kenya, Agabus austellus sp. nov. a widespread species in South Africa, Agabus riberae sp. nov. from the Kamiesberg and northeastern Cederberg ranges in the Northern and Western Cape Provinces …
The Emotional Impact Of The Covid-19 Pandemic On Individuals With Progressive Multiple Sclerosis, Nancy D. Chiaravalloti, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Ulrik Dalgas, John Deluca, Cecilia Meza, Nancy B. Moore, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Rob Motl, Maria Assunta Rocca, Brian M. Sandroff, Amber Salter, Gary Cutter, Anthony Feinstein
The Emotional Impact Of The Covid-19 Pandemic On Individuals With Progressive Multiple Sclerosis, Nancy D. Chiaravalloti, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Ulrik Dalgas, John Deluca, Cecilia Meza, Nancy B. Moore, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Rob Motl, Maria Assunta Rocca, Brian M. Sandroff, Amber Salter, Gary Cutter, Anthony Feinstein
School of Health Professions
No abstract provided.
An Interactive Compositional Tool Using The Electroencephalogram, R Horrell
An Interactive Compositional Tool Using The Electroencephalogram, R Horrell
School of Art, Design and Architecture
This paper proposes an interactive approach to aid the compositional process using the brain-computer music interface (BCMI). In particular, the system developed in this paper focuses on creating an interactive compositional process inclusive to non-musicians and those with motor disabilities, in addition to providing a new method of composing. This paper references and compares two BCMI systems that have been developed for compositional purposes and draws upon these ideas to form the proposed system in this paper. Such system would aid the compositional process based on note velocity, chords and key changes.
Assessing Options For Remediation Of Contaminated Mine Site Drainage Entering The River Teign, Southwest England, Abigail Jordan, Rachel Hill, Adrienne Turner, Tyrone Roberts, Sean Comber
Assessing Options For Remediation Of Contaminated Mine Site Drainage Entering The River Teign, Southwest England, Abigail Jordan, Rachel Hill, Adrienne Turner, Tyrone Roberts, Sean Comber
School of Geography, Earth and Environmental Sciences
The river Teign in Devon has come under scrutiny for failing to meet environmental quality standards for ecotoxic metals due to past mining operations. A disused mine known as Bridford Barytes mine, has been found to contribute a significant source of Zn, Cd and Pb to the river. Recently, studies have been focused on the remediation of such mine sites using low-cost treatment methods to help reduce metal loads to the river downstream. This paper explores the metal removal efficiency of red mud, a waste product from the aluminium industry, which has proven to be an attractive low-cost treatment method …
Seasonal Predictions Of Shoreline Change, Informed By Climate Indices, Dan Hilton, Mark Davidson, Tim Scott
Seasonal Predictions Of Shoreline Change, Informed By Climate Indices, Dan Hilton, Mark Davidson, Tim Scott
School of Biological and Marine Sciences
With sea level rise accelerating and coastal populations increasing, the requirement of coastal managers and scientists to produce accurate predictions of shoreline change is becoming ever more urgent. Waves are the primary driver of coastal evolution, and much of the interannual variability of the wave conditions in the Northeast Atlantic can be explained by broadscale patterns in atmospheric circulation. Two of the dominant climate indices that capture the wave climate in western Europe’s coastal regions are the ‘Western Europe Pressure Anomaly’ (WEPA) and ‘North Atlantic Oscillation’ (NAO). This study utilises a shoreline prediction model (ShoreFor) which is forced by synthetic …
Genetic Music System With Synthetic Biology, Eduardo Reck Miranda
Genetic Music System With Synthetic Biology, Eduardo Reck Miranda
School of Art, Design and Architecture
This paper introduces GeMS, a system for music composition informed by Synthetic Biology. GeMS generates music with simulations of genetic processes, such as transcription, translation and protein folding, with which biological systems render chains of amino acids from DNA strands. The system comprises the following components: the Miranda Machine, the Rhythmator and the Pitch Processor. The Miranda Machine is an abstract Turing Machine-like processor, which manipulates a sequence of DNA symbols according to a set of programming instructions. This process generates a pool of new DNA strands, which are subsequently translated into rhythms. GeMS represents the musical equivalent of amino …
Absence Of Cross-Modality Analogical Transfer In Perceptual Categorization, C Edmunds, A Inkster, P Jones, F Milton, A Wills
Absence Of Cross-Modality Analogical Transfer In Perceptual Categorization, C Edmunds, A Inkster, P Jones, F Milton, A Wills
School of Psychology
No abstract provided.
Accept - Combining Acalabrutinib With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine And Prednisolone (R-Chop) For Diffuse Large B-Cell Lymphoma (Dlbcl): Study Protocol For A Phase Ib/Ii Open-Label Non-Randomised Clinical Trial, A Davies, S Barrans, C Burton, K Mercer, Et Al
Accept - Combining Acalabrutinib With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine And Prednisolone (R-Chop) For Diffuse Large B-Cell Lymphoma (Dlbcl): Study Protocol For A Phase Ib/Ii Open-Label Non-Randomised Clinical Trial, A Davies, S Barrans, C Burton, K Mercer, Et Al
Peninsula Medical School
Background: Over 13,000 new cases of non-Hodgkin’s lymphoma (NHL) are diagnosed in the UK, with approximately 4,900 attributable deaths each year. Diffuse Large B-cell Lymphoma (DLBCL) is the most common NHL comprising one third of adult NHL cases. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) is accepted as the international standard first-line regimen, but improvement in first line treatment is needed. Dysregulated B-cell receptor (BCR) signalling has been identified as a feature of DLBCL. Inhibition of Bruton’s tyrosine kinase (Btk), downstream of the BCR has proven efficacious in other B-cell malignancies and in combination with R-CHOP. The second generation Btk inhibitor, …
A Systematic Approach To Review Of In Vitro Methods In Brain Tumour Research (Satori-Btr): Development Of A Preliminary Checklist For Evaluating Quality And Human Relevance, Mike Bracher, Gj Pilkington, C. Oliver Hanemann, K Pilkington
A Systematic Approach To Review Of In Vitro Methods In Brain Tumour Research (Satori-Btr): Development Of A Preliminary Checklist For Evaluating Quality And Human Relevance, Mike Bracher, Gj Pilkington, C. Oliver Hanemann, K Pilkington
Peninsula Medical School
No abstract provided.
Modelling Scenarios Of Environmental Recovery After Implementation Of Controls On Emissions Of Persistent Organic Pollutants, S. D.W. Comber, M. J. Gardner, C. Constantino, S. Firth, A. Hargreaves, R. Davies
Modelling Scenarios Of Environmental Recovery After Implementation Of Controls On Emissions Of Persistent Organic Pollutants, S. D.W. Comber, M. J. Gardner, C. Constantino, S. Firth, A. Hargreaves, R. Davies
School of Geography, Earth and Environmental Sciences
Predictions of BaP concentrations in biota decreasing towards the EQS over time.
Final 5-Year Findings From The Phase 3 Helios Study Of Ibrutinib Plus Bendamustine And Rituximab In Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Gam Fraser, S Rule, Et Al
Final 5-Year Findings From The Phase 3 Helios Study Of Ibrutinib Plus Bendamustine And Rituximab In Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Gam Fraser, S Rule, Et Al
Peninsula Medical School
We report final analysis outcomes from the phase 3 HELIOS study (NCT01611090). Patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma without deletion 17p (n = 578) were randomized 1:1 to 420 mg daily ibrutinib or placebo plus ≤6 cycles of bendamustine plus rituximab (BR), followed by ibrutinib or placebo alone. Median follow-up was 63.7 months. Median investigator-assessed progression-free survival was longer with ibrutinib plus BR (65.1 months) than placebo plus BR (14.3 months; hazard ratio [HR] 0.229 [95% confidence interval (CI) 0.183-0.286]; p < .0001). Despite crossover of 63.3% of patients from the placebo plus BR arm to ibrutinib treatment upon disease progression, ibrutinib plus BR versus placebo plus BR demonstrated an overall survival benefit (HR 0.611 [95% CI 0.455-0.822]; p = .0010; median not reached in either arm). Long-term follow-up data confirm the survival benefit of ibrutinib plus BR over BR alone. Safety profiles were consistent with those known for ibrutinib and BR.