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Articles 1981 - 2010 of 6794
Full-Text Articles in Entire DC Network
Coping With Fibromyalgia During The Covid-19 Pandemic: Adjustment And Wellbeing, Alison M. Bacon, Leah White, Alyson Norman
Coping With Fibromyalgia During The Covid-19 Pandemic: Adjustment And Wellbeing, Alison M. Bacon, Leah White, Alyson Norman
School of Psychology
ObjectiveFibromyalgia syndrome (FMS) is a chronic condition with symptoms known to be exacerbated by stress. Individuals with FMS may be experiencing particular distress under Covid-19 pandemic-related lifestyle restrictions. The present study examined wellbeing, perceived symptom change and coping in individuals with and without FMS during pandemic-related social lockdown in the UK.DesignParticipants with a diagnosis of FMS (N = 390) and a general public sample with no FMS (N = 151) completed questionnaires at three time points.Main Outcome MeasuresBBC Wellbeing Scale, Cognitive-Emotional Regulation Questionnaire measure of coping, perception of extent to which symptoms have worsened or improved over time.ResultsContrary to expectations, …
Impact Of Growth Media And Pressure On The Diversity And Antimicrobial Activity Of Isolates From Two Species Of Hexactinellid Sponge, Matthew J. Koch, Poppy J. Hesketh-Best, Gary Smerdon, Philip J. Warburton, Kerry Howell, Mathew Upton
Impact Of Growth Media And Pressure On The Diversity And Antimicrobial Activity Of Isolates From Two Species Of Hexactinellid Sponge, Matthew J. Koch, Poppy J. Hesketh-Best, Gary Smerdon, Philip J. Warburton, Kerry Howell, Mathew Upton
School of Biomedical Sciences
Access to deep-sea sponges brings with it the potential to discover novel antimicrobial candidates, as well as novel cold- and pressure-adapted bacteria with further potential clinical or industrial applications. In this study, we implemented a combination of different growth media, increased pressure and high-throughput techniques to optimize recovery of isolates from two deep-sea hexactinellid sponges, Pheronema carpenteri and Hertwigia sp., in the first culture-based microbial analysis of these two sponges. Using 16S rRNA gene sequencing for isolate identification, we found a similar number of cultivable taxa from each sponge species, as well as improved recovery of morphotypes from P. carpenteri …
A Global Atlas Of Artificial Light At Night Under The Sea, T. J. Smyth, A. E. Wright, D. Mckee, S. Tidau, R. Tamir, Z. Dubinsky, D. Iluz, T. W. Davies
A Global Atlas Of Artificial Light At Night Under The Sea, T. J. Smyth, A. E. Wright, D. Mckee, S. Tidau, R. Tamir, Z. Dubinsky, D. Iluz, T. W. Davies
School of Biological and Marine Sciences
The impacts of artificial light at night (ALAN) on marine ecosystems have emerged as a focus for ecological light pollution research in recent years, yet the global prevalence of ALAN in underwater marine ecosystems is unknown. We have derived a global atlas of ALAN throughout the marine water column that will accelerate our understanding of its sources and environmental impacts. At a depth of 1 m, 1.9 million km2 of the world’s coastal seas are exposed to biologically important ALAN, which equates to around 3.1% of the global exclusive economic zones. This area decreases to 1.6 million km2 (2.7%) at …
Understanding Coralline Algal Responses To Ocean Acidification: Meta‐Analysis And Synthesis, Ce Cornwall, Ben P. Harvey, Steeve Comeau, Dl Cornwall, Jason Hall‐Spencer, Viviana Peña, Shigeki Wada, Lucia Porzio
Understanding Coralline Algal Responses To Ocean Acidification: Meta‐Analysis And Synthesis, Ce Cornwall, Ben P. Harvey, Steeve Comeau, Dl Cornwall, Jason Hall‐Spencer, Viviana Peña, Shigeki Wada, Lucia Porzio
School of Biological and Marine Sciences
Ocean acidification (OA) is a major threat to the persistence of biogenic reefs throughout the world's ocean. Coralline algae are comprised of high magnesium calcite and have long been considered one of the most susceptible taxa to the negative impacts of OA. We summarize these impacts and explore the causes of variability in coralline algal responses using a review/qualitative assessment of all relevant literature, meta-analysis, quantitative assessment of critical responses, and a discussion of physiological mechanisms and directions for future research. We find that most coralline algae experienced reduced abundance, calcification rates, recruitment rates, and declines in pH within the …
Is Activation Of Gdnf/Ret Signaling The Answer For Successful Treatment Of Parkinson's Disease? A Discussion Of Data From The Culture Dish To The Clinic, James A. Conway, Edgar R. Kramer
Is Activation Of Gdnf/Ret Signaling The Answer For Successful Treatment Of Parkinson's Disease? A Discussion Of Data From The Culture Dish To The Clinic, James A. Conway, Edgar R. Kramer
Peninsula Medical School
The neurotrophic signaling of glial cell line-derived neurotrophic factor (GDNF) with its canonical receptor, the receptor tyrosine kinase RET, coupled together with the GDNF family receptor alpha 1 is important for dopaminergic neuron survival and physiology in cell culture experiments and animal models. This prompted the idea to try GDNF/RET signaling as a therapeutic approach to treat Parkinson's disease with the hallmark of dopaminergic cell death in the substantia nigra of the midbrain. Despite several clinical trials with GDNF in Parkinson's disease patients, which mainly focused on optimizing the GDNF delivery technique, benefits were only seen in a few patients. …
11 Pressing Research Questions On How Light Pollution Affects Biodiversity, Franz Holker, Janine Bolliger, Thomas W. Davies, Simone Giavi, Andreas Jechow, Gregor Kalinkat, Travis Longcore, Kamiel Spoelstra, Svenja Tidau, Marcel E. Visser, Eva Knopp
11 Pressing Research Questions On How Light Pollution Affects Biodiversity, Franz Holker, Janine Bolliger, Thomas W. Davies, Simone Giavi, Andreas Jechow, Gregor Kalinkat, Travis Longcore, Kamiel Spoelstra, Svenja Tidau, Marcel E. Visser, Eva Knopp
School of Biological and Marine Sciences
Artificial light at night (ALAN) is closely associated with modern societies and is rapidly increasing worldwide. A dynamically growing body of literature shows that ALAN poses a serious threat to all levels of biodiversity—from genes to ecosystems. Many “unknowns” remain to be addressed however, before we fully understand the impact of ALAN on biodiversity and can design effective mitigation measures. Here, we distilled the findings of a workshop on the effects of ALAN on biodiversity at the first World Biodiversity Forum in Davos attended by several major research groups in the field from across the globe. We argue that 11 …
Single-Cell Regulatory Network Inference And Clustering Identifies Cell-Type Specific Expression Pattern Of Transcription Factors In Mouse Sciatic Nerve, Mingchao Li, Qing Min, Matthew C. Banton, Xinpeng Dun
Single-Cell Regulatory Network Inference And Clustering Identifies Cell-Type Specific Expression Pattern Of Transcription Factors In Mouse Sciatic Nerve, Mingchao Li, Qing Min, Matthew C. Banton, Xinpeng Dun
School of Biomedical Sciences
Advances in single-cell RNA sequencing technologies and bioinformatics methods allow for both the identification of cell types in a complex tissue and the large-scale gene expression profiling of various cell types in a mixture. In this report, we analyzed a single-cell RNA sequencing (scRNA-seq) dataset for the intact adult mouse sciatic nerve and examined cell-type specific transcription factor expression and activity during peripheral nerve homeostasis. In total, we identified 238 transcription factors expressed in nine different cell types of intact mouse sciatic nerve. Vascular smooth muscle cells have the lowest number of transcription factors expressed with 17 transcription factors identified. …
The Plankton Lifeform Extraction Tool: A Digital Tool To Increase The Discoverability And Usability Of Plankton Time-Series Data, Clare Ostle, Kevin Paxman, Carolyn A. Graves, Mathew Arnold, Luis Felipe Artigas, Angus Atkinson, Anais Aubert, Malcolm Baptie, Beth Bear, Jacob Bedford, Michael Best, Eileen Bresnan, Rachel Brittain, Derek Broughton, Alexandre Budria, Kathryn Cook, Michelle Devlin, George Graham, Nick Halliday, P Hélaouët, Marie Johansen, David G. Johns, Dan Lear, Margarita Machairopoulou, April Mckinney, Adam Mellor, Alex Milligan, Sophie Pitois, Isabelle Rombouts, Cordula Scherer, Paul Tett, Claire Widdicombe, Abigail Mcquatters-Gollop
The Plankton Lifeform Extraction Tool: A Digital Tool To Increase The Discoverability And Usability Of Plankton Time-Series Data, Clare Ostle, Kevin Paxman, Carolyn A. Graves, Mathew Arnold, Luis Felipe Artigas, Angus Atkinson, Anais Aubert, Malcolm Baptie, Beth Bear, Jacob Bedford, Michael Best, Eileen Bresnan, Rachel Brittain, Derek Broughton, Alexandre Budria, Kathryn Cook, Michelle Devlin, George Graham, Nick Halliday, P Hélaouët, Marie Johansen, David G. Johns, Dan Lear, Margarita Machairopoulou, April Mckinney, Adam Mellor, Alex Milligan, Sophie Pitois, Isabelle Rombouts, Cordula Scherer, Paul Tett, Claire Widdicombe, Abigail Mcquatters-Gollop
School of Biological and Marine Sciences
Abstract. Plankton form the base of the marine food web and are sensitive indicatorsof environmental change. Plankton time series are therefore an essentialpart of monitoring progress towards global biodiversity goals, such as theConvention on Biological Diversity Aichi Targets, and for informingecosystem-based policy, such as the EU Marine Strategy Framework Directive.Multiple plankton monitoring programmes exist in Europe, but differences insampling and analysis methods prevent the integration of their data,constraining their utility over large spatio-temporal scales. The PlanktonLifeform Extraction Tool brings together disparate European planktondatasets into a central database from which it extracts abundancetime series of plankton functional groups, called “lifeforms”, according …
Editorial: Biodiversity, Connectivity And Ecosystem Function Across The Clarion-Clipperton Zone: A Regional Synthesis For An Area Targeted For Nodule Mining, Craig R. Smith, Malcolm R. Clark, Erica Goetze, Adrian G. Glover, Kerry L. Howell
Editorial: Biodiversity, Connectivity And Ecosystem Function Across The Clarion-Clipperton Zone: A Regional Synthesis For An Area Targeted For Nodule Mining, Craig R. Smith, Malcolm R. Clark, Erica Goetze, Adrian G. Glover, Kerry L. Howell
School of Biological and Marine Sciences
The Clarion Clipperton Zone (CCZ) in the equatorial Pacific Ocean is a vast region of abyssal plains and hills, polymetallic nodule fields, and seamounts. Because of the cobalt, nickel and copper content of polymetallic nodules in this region, the CCZ is targeted for deep-seabed mining. In order to safeguard seafloor biodiversity and ecosystem functions across the region in the event of mining, the International Seabed Authority (ISA) in 2012 designated nine 400×400 km no-mining areas, called Areas of Particular Environmental Interest (APEIs) (Wedding et al., 2013). The APEIs were designed based on environmental correlates of biodiversity and ecosystem function to …
Late Ordovician Climate Change And Extinctions Driven By Elevated Volcanic Nutrient Supply, Jack Longman, Benjamin J.W. Mills, Hayley R. Manners, Thomas M. Gernon, Martin R. Palmer
Late Ordovician Climate Change And Extinctions Driven By Elevated Volcanic Nutrient Supply, Jack Longman, Benjamin J.W. Mills, Hayley R. Manners, Thomas M. Gernon, Martin R. Palmer
School of Geography, Earth and Environmental Sciences
The Late Ordovician (~459–444 million years ago) was characterized by global cooling, glaciation and severe mass extinction. These events may have been driven by increased delivery of the nutrient phosphorus (P) to the ocean and associated increases in marine productivity, but it is not clear why this occurred in the two pulses identified in the geological record. We link both cooling phases—and the extinction—to volcanic eruptions through marine deposition of nutrient-rich ash and the weathering of terrestrially emplaced ash and lava. We then reconstruct the influence of Late Ordovician volcanic P delivery on the marine system by coupling an estimate …
Eye-Transcriptome And Genome-Wide Sequencing For Scolecophidia: Implications For Inferring The Visual System Of The Ancestral Snake, David J. Gower, James F. Fleming, Davide Pisani, Freek J. Vonk, Harald M.I. Kerkkamp, Leo Peichl, Sonja Meimann, Nicholas R. Casewell, Christiaan V. Henkel, Michael K. Richardson, Kate L. Sanders, Bruno F. Simões
Eye-Transcriptome And Genome-Wide Sequencing For Scolecophidia: Implications For Inferring The Visual System Of The Ancestral Snake, David J. Gower, James F. Fleming, Davide Pisani, Freek J. Vonk, Harald M.I. Kerkkamp, Leo Peichl, Sonja Meimann, Nicholas R. Casewell, Christiaan V. Henkel, Michael K. Richardson, Kate L. Sanders, Bruno F. Simões
More Faculty of Science and Engineering Research
Molecular genetic data have recently been incorporated in attempts to reconstruct the ecology of the ancestral snake, though this has been limited by a paucity of data for one of the two main extant snake taxa, the highly fossorial Scolecophidia. Here we present and analyze vision genes from the first eye-transcriptomic and genome-wide data for Scolecophidia, for Anilios bicolor, and A. bituberculatus, respectively. We also present immunohistochemistry data for retinal anatomy and visual opsin-gene expression in Anilios. Analyzed in the context of 19 lepidosaurian genomes and 12 eye transcriptomes, the new genome-wide and transcriptomic data provide evidence for a much …
Potential Microplastic Release From Beached Fishing Gear In Great Britain's Region Of Highest Fishing Litter Density, Luka Seamus Wright, Imogen Ellen Napper, Richard C. Thompson
Potential Microplastic Release From Beached Fishing Gear In Great Britain's Region Of Highest Fishing Litter Density, Luka Seamus Wright, Imogen Ellen Napper, Richard C. Thompson
School of Biological and Marine Sciences
While land-based sources of marine plastic pollution have gained widespread attention, marine-based sources are less extensively investigated. Here, we provide the first in-depth description of abandoned, lost or otherwise discarded fishing gear (ALDFG) on northern and southern beaches of the English Southwest Peninsula, Great Britain's region of highest ALDFG density. Three distinct categories were recorded: twisted rope (0.28 ± 0.14 m−1, 17%), braided rope (0.56 ± 0.28 m−1, 33%) and filament (0.84 ± 0.41 m−1, 50%), which likely correspond to fishing rope, net and line. Estimating the disintegration of ALDFG from length and filament number suggests that it has the …
Current Status And Natural History Of The Critically Endangered Variable Harlequin Toad (Atelopus Varius) In Costa Rica, C Barrio-Amorós, G Chaves, R Puschendorf
Current Status And Natural History Of The Critically Endangered Variable Harlequin Toad (Atelopus Varius) In Costa Rica, C Barrio-Amorós, G Chaves, R Puschendorf
School of Biological and Marine Sciences
No abstract provided.
Coastal Adaptation To Climate Change Through Zonation: A Review Of Coastal Change Management Areas (Ccmas) In England, J. A. Kirby, G. Masselink, S. Essex, T. Poate, T. Scott
Coastal Adaptation To Climate Change Through Zonation: A Review Of Coastal Change Management Areas (Ccmas) In England, J. A. Kirby, G. Masselink, S. Essex, T. Poate, T. Scott
School of Biological and Marine Sciences
Climate change and accelerated rates in sea-level rise are expected to increase flooding and erosion on the world's coastlines. Coastal managers and planners face the challenge of helping communities to adapt to the changing coast. Traditionally hard engineering has been used to defend communities on the coast, but as this option becomes unsustainable and financially unviable, coastal managers are increasingly employing planning policy to mitigate the risk posed by coastal change. Zonation of coastal change areas and delineation of erosion extents, such as set-back lines, are used globally to restrict development in the coastal zone. In England there is policy …
Seasonal Sea Ice Persisted Through The Holocene Thermal Maximum At 80°N, Anna J. Pieńkowski, Katrine Husum, Simon T. Belt, Ulysses Ninnemann, Denizcan Köseoğlu, Dmitry V. Divine, Lukas Smik, Jochen Knies, Kelly Hogan, Riko Noormets
Seasonal Sea Ice Persisted Through The Holocene Thermal Maximum At 80°N, Anna J. Pieńkowski, Katrine Husum, Simon T. Belt, Ulysses Ninnemann, Denizcan Köseoğlu, Dmitry V. Divine, Lukas Smik, Jochen Knies, Kelly Hogan, Riko Noormets
School of Geography, Earth and Environmental Sciences
The cryospheric response to climatic warming responsible for recent Arctic sea ice decline can be elucidated using marine geological archives which offer an important long-term perspective. The Holocene Thermal Maximum, between 10 and 6 thousand years ago, provides an opportunity to investigate sea ice during a warmer-than-present interval. Here we use organic biomarkers and benthic foraminiferal stable isotope data from two sediment cores in the northernmost Barents Sea (>80 °N) to reconstruct seasonal sea ice between 11.7 and 9.1 thousand years ago. We identify the continued persistence of sea-ice biomarkers which suggest spring sea ice concentrations as high as …
Green Synthesis Of Silver Nanoparticles From Heteropyxis Natalensis Leaf Extract And Their Potential Antibacterial Efficacy, Meer S. D., Yougasphree Naidoo, Dewir Y H., Johnson Lin, Rihan H Z.
Green Synthesis Of Silver Nanoparticles From Heteropyxis Natalensis Leaf Extract And Their Potential Antibacterial Efficacy, Meer S. D., Yougasphree Naidoo, Dewir Y H., Johnson Lin, Rihan H Z.
More Faculty of Science and Engineering Research
No abstract provided.
Genotoxicity Evaluation Of Medical Devices: A Regulatory Perspective, Awadhesh N. Jha, Tirukalikundram S. Kumaravel, Tiruvathipuram N. Sathya, Ramalingam Balaje, Pitchaipillai Pradeepa, Desikan Yogaraj, Malliga R. Murali, K. R. Navaneethakrishnan, Sivasubramanian Murugan
Genotoxicity Evaluation Of Medical Devices: A Regulatory Perspective, Awadhesh N. Jha, Tirukalikundram S. Kumaravel, Tiruvathipuram N. Sathya, Ramalingam Balaje, Pitchaipillai Pradeepa, Desikan Yogaraj, Malliga R. Murali, K. R. Navaneethakrishnan, Sivasubramanian Murugan
School of Biological and Marine Sciences
This review critically evaluates our current regulatory understanding of genotoxicity testing and risk assessment of medical devices. Genotoxicity risk assessment of these devices begins with the evaluation of materials of construction, manufacturing additives and all residual materials for potential to induce DNA damage. This is followed by extractable and/or leachable (E&L) studies to understand the worst case and/or clinical exposures, coupled with risk assessment of extractables or leachables. The TTC (Threshold of Toxicological Concern) approach is used to define acceptable levels of genotoxic chemicals, when identified. Where appropriate, in silico predictions may be used to evaluate the genotoxic potentials of …
Estimating Pelagic Fish Biomass In A Tropical Seascape Using Echosounding And Baited Stereo-Videography, Tom B. Letessier, Roland Proud, Jessica J. Meeuwig, Martin J. Cox, Phil J. Hosegood, Andrew S. Brierley
Estimating Pelagic Fish Biomass In A Tropical Seascape Using Echosounding And Baited Stereo-Videography, Tom B. Letessier, Roland Proud, Jessica J. Meeuwig, Martin J. Cox, Phil J. Hosegood, Andrew S. Brierley
School of Biological and Marine Sciences
No abstract provided.
Best Practices For Monitoring And Assessing The Ecological Response To River Restoration, Judy England, Natalie Angelopoulos, Susan Cooksley, Jennifer Dodd, Andrew Gill, David Gilvear, Matthew Johnson, Marc Naura, Matthew O’Hare, Angus Tree, Jennifer Wheeldon, Martin A. Wilkes
Best Practices For Monitoring And Assessing The Ecological Response To River Restoration, Judy England, Natalie Angelopoulos, Susan Cooksley, Jennifer Dodd, Andrew Gill, David Gilvear, Matthew Johnson, Marc Naura, Matthew O’Hare, Angus Tree, Jennifer Wheeldon, Martin A. Wilkes
School of Geography, Earth and Environmental Sciences
Nature-based solutions are widely advocated for freshwater ecosystem conservation and restoration. As increasing amounts of river restoration are undertaken, the need to understand the ecological response to different measures and where measures are best applied becomes more pressing. It is essential that appraisal methods follow a sound scientific approach. Here, experienced restoration appraisal experts review current best practice and academic knowledge to make recommendations and provide guidance that will enable practitioners to gather and analyse meaningful data, using scientific rigor to appraise restoration success. What should be monitored depends on the river type and the type and scale of intervention. …
A Real-Time Double Emulsion Droplets Detection System Using Hough Circle Transform And Color Detection, Shuo Zhu, Chunxu Li, James Rogers, Mario Gianni, Ian Howard
A Real-Time Double Emulsion Droplets Detection System Using Hough Circle Transform And Color Detection, Shuo Zhu, Chunxu Li, James Rogers, Mario Gianni, Ian Howard
School of Engineering, Computing and Mathematics
No abstract provided.
Optimise: Ms Study Protocol: A Pragmatic, Prospective Observational Study To Address The Need For, And Challenges With, Real World Pharmacovigilance In Multiple Sclerosis, Ruth Dobson, Matthew Craner, Ed Waddingham, Aleisha Miller, Ana Cavey, Stewart Webb, Cheryl Hemingway, Jeremy Hobart, Nikos Evangelou, Neil Scolding, David Rog, Richard Nicholas, Monica Marta, Camilla Blain, Carolyn Anne Young, Helen L. Ford, Paul M. Matthews
Optimise: Ms Study Protocol: A Pragmatic, Prospective Observational Study To Address The Need For, And Challenges With, Real World Pharmacovigilance In Multiple Sclerosis, Ruth Dobson, Matthew Craner, Ed Waddingham, Aleisha Miller, Ana Cavey, Stewart Webb, Cheryl Hemingway, Jeremy Hobart, Nikos Evangelou, Neil Scolding, David Rog, Richard Nicholas, Monica Marta, Camilla Blain, Carolyn Anne Young, Helen L. Ford, Paul M. Matthews
Peninsula Medical School
IntroductionThe power of ‘real world’ data to improve our understanding of the clinical aspects of multiple sclerosis (MS) is starting to be realised. Disease modifying therapy (DMT) use across the UK is driven by national prescribing guidelines. As such, the UK provides an ideal country in which to gather MS outcomes data. A rigorously conducted observational study with a focus on pharmacovigilance has the potential to provide important data to inform clinicians and patients while testing the reliability of estimates from pivotal trials when applied to patients in the UK.Methods and analysisThe primary aim of this study is to characterise …
Subcutaneous Cladribine To Treat Multiple Sclerosis: Experience In 208 Patients, Kimberley Allen-Philbey, Trane S De, Zhifeng Mao, Cesar Álvarez-González, Joela Mathews, Amy Macdougall, Andrea Stennett, Xia Zhou, Ozlem Yildiz, Ashok Adams, Lucia Bianchi, Camilla Blain, Christine Chapman, Karen Chung, Cris S. Constantinescu, Catherine Dalton, Rachel A. Farrell, Leonora Fisniku, Helen Ford, Bruno Gran, Jeremy Hobart, Zhaleh Khaleeli, Miriam Mattoscio, Sue Pavitt, Owen Pearson, Luca Peruzzotti-Jametti, Antonio Scalfari, Basil Sharrack, Eli Silber, Eli Silber, Stewart Webb, Benjamin P. Turner, Monica Marta, Sharmilee Gnanapavan, Gunnar Juliusson, Gavin Giovannoni, David Baker, Klaus Schmierer
Subcutaneous Cladribine To Treat Multiple Sclerosis: Experience In 208 Patients, Kimberley Allen-Philbey, Trane S De, Zhifeng Mao, Cesar Álvarez-González, Joela Mathews, Amy Macdougall, Andrea Stennett, Xia Zhou, Ozlem Yildiz, Ashok Adams, Lucia Bianchi, Camilla Blain, Christine Chapman, Karen Chung, Cris S. Constantinescu, Catherine Dalton, Rachel A. Farrell, Leonora Fisniku, Helen Ford, Bruno Gran, Jeremy Hobart, Zhaleh Khaleeli, Miriam Mattoscio, Sue Pavitt, Owen Pearson, Luca Peruzzotti-Jametti, Antonio Scalfari, Basil Sharrack, Eli Silber, Eli Silber, Stewart Webb, Benjamin P. Turner, Monica Marta, Sharmilee Gnanapavan, Gunnar Juliusson, Gavin Giovannoni, David Baker, Klaus Schmierer
Peninsula Medical School
Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak®) in multiple sclerosis (MS) patients. Methods: Litak® was offered to MS-patients irrespective of disease course. Litak® 10 mg was administered for 3–4 days during week 1. Based on lymphocyte count at week 4, patients received another 0–3 doses at week 5. A second course was administered 11 months later. Follow-up included adverse events, relapses, expanded disability status scale (EDSS), 9-hole-peg and Timed-25-foot-walking tests, no-evidence-of-disease-activity (NEDA), no-evidence-of-progression-or-active-disease (NEPAD), MRI, cerebrospinal fluid (CSF) neurofilament light chain (NfL), and lymphocyte counts. Results: In all, 208 patients received at least one course of …
Source, Sea And Sink—A Holistic Approach To Understanding Plastic Pollution In The Southern Caribbean, Winnie Courtene-Jones, Taylor Maddalene, Molly K. James, Natalie S. Smith, Kathryn Youngblood, Jenna R. Jambeck, Sally Earthrowl, Denise Delvalle-Borrero, Emily Penn, Richard C. Thompson
Source, Sea And Sink—A Holistic Approach To Understanding Plastic Pollution In The Southern Caribbean, Winnie Courtene-Jones, Taylor Maddalene, Molly K. James, Natalie S. Smith, Kathryn Youngblood, Jenna R. Jambeck, Sally Earthrowl, Denise Delvalle-Borrero, Emily Penn, Richard C. Thompson
School of Biological and Marine Sciences
Marine plastics are considered to be a major threat to the sustainable use of marine and coastal resources of the Caribbean, on which the region relies heavily for tourism and fishing. To date, little work has quantified plastics within the Caribbean marine environment or examined their potential sources. This study aimed to address this by holistically integrating marine (surface water, subsurface water and sediment) and terrestrial sampling and Lagrangian particle tracking to examine the potential origins, flows and quantities of plastics within the Southern Caribbean. Terrestrial litter and the microplastics identified in marine samples may arise from the maritime and …
Are Sustainable Drainage Systems (Suds) Effective At Retaining Dissolved Trace Elements?, Jasmine Humphrey, Chris Rowett, Jonathan Tyers, Mark Gregson, Sean Comber
Are Sustainable Drainage Systems (Suds) Effective At Retaining Dissolved Trace Elements?, Jasmine Humphrey, Chris Rowett, Jonathan Tyers, Mark Gregson, Sean Comber
School of Geography, Earth and Environmental Sciences
No abstract provided.
Putting Nature Centre Stage? The Challenges Of ‘Mainstreaming’ Biodiversity In The Planning Process, Olivia Wilson
Putting Nature Centre Stage? The Challenges Of ‘Mainstreaming’ Biodiversity In The Planning Process, Olivia Wilson
School of Geography, Earth and Environmental Sciences
No abstract provided.
Metal Pollutant Pathways In Cohesive Coastal Catchments: Influence Of Flocculation And Biopolymers On Partitioning And Flux, R. J. Schindler, S. D.W. Comber, A. J. Manning
Metal Pollutant Pathways In Cohesive Coastal Catchments: Influence Of Flocculation And Biopolymers On Partitioning And Flux, R. J. Schindler, S. D.W. Comber, A. J. Manning
School of Geography, Earth and Environmental Sciences
No abstract provided.
Improving Search Engine Performance Through Dynamic Caching, C Gutierrez-Soto, Ma Palomino, E Roa, P Galdames
Improving Search Engine Performance Through Dynamic Caching, C Gutierrez-Soto, Ma Palomino, E Roa, P Galdames
School of Engineering, Computing and Mathematics
No abstract provided.
Photosynthetic Pigments Of Co-Occurring Northeast Atlantic Laminaria Spp. Are Unaffected By Decomposition, Ls Wright, A Foggo
Photosynthetic Pigments Of Co-Occurring Northeast Atlantic Laminaria Spp. Are Unaffected By Decomposition, Ls Wright, A Foggo
School of Biological and Marine Sciences
Along Northeast Atlantic coasts, the genus Laminaria dominates kelp forests. Two species, L. digitata and L. hyperborea, are cold temperate whilst the third, L. ochroleuca, is warm temperate. In northern France and the southern British Isles, all 3 species now co-occur, with a gradual rise in predominance of L. ochroleuca evident over recent decades due to climate-driven range shifts. Despite recent focus on the export of photosynthetically viable macroalgal detritus, the effect of decomposition on detrital pigment concentration remains unknown for northern hemisphere kelps. Furthermore, notwithstanding their importance in determining habitat suitability, the photosynthetic pigments of all 3 species have …
Better Together: Analysis Of Integrated Acoustic And Visual Methods When Surveying A Cetacean Community, L. Dalpaz, A. D. Paro, F. G. Daura-Jorge, M. Rossi-Santos, T. F. Norris, S. N. Ingram, L. L. Wedekin
Better Together: Analysis Of Integrated Acoustic And Visual Methods When Surveying A Cetacean Community, L. Dalpaz, A. D. Paro, F. G. Daura-Jorge, M. Rossi-Santos, T. F. Norris, S. N. Ingram, L. L. Wedekin
School of Biological and Marine Sciences
Understanding the relative performance of data collection methods is critical for the production of robust results in any biological field study. This is particularly relevant for monitoring studies of rare and inconspicuous species, such as some cetaceans. Here, we compared how passive acoustic and visual survey methods performed when surveying a multispecies cetacean community in a large-scale survey area and whether the simultaneous application of these methods leads to complementary results. For both methods we compared (1) frequency of unscheduled survey stoppages, (2) detection ranges, (3) success in identifying species, (4) precedence of either method in synchronous detections, (5) detection …
The Impact Of The Covid-19 Pandemic On An International Rehabilitation Study In Ms: The Cogex Experience, Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Rob Motl, Maria Assunta Rocca, Brian M. Sandroff, Amber Salter
The Impact Of The Covid-19 Pandemic On An International Rehabilitation Study In Ms: The Cogex Experience, Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Rob Motl, Maria Assunta Rocca, Brian M. Sandroff, Amber Salter
School of Health Professions
No abstract provided.