Digital Commons Network^™

Finite Element Analysis Of A Total Wrist Replacement: Determining Implant Lifetime Due To Fatigue, Edward Alton

The Plymouth Student Scientist

Total wrist replacement is a surgery in which an implant is used to help a patient regain a full range of painless movement in their wrist. However, there is little data to suggest the lifetime of implants when being used, implants should last as long as possible to reduce possible harm to patients and reduce the need of more surgery. This paper aims to use finite element analysis (FEA) to develop a model of a total wrist replacement and therefore develop a fatigue analysis based on the typical use of the implant. Results from the FEA were further corroborated using …

Ecological Impacts Of The Non-Native Macrophyte Crassula Helmsii On Freshwater Macroinvertebrate Assemblages In Dartmoor National Park, Uk, Salvatore Giordano

The Plymouth Student Scientist

Invasive species are a major threat to biodiversity globally. In freshwater ecosystems, invasive macrophytes are one of the most significant hazards. This study evaluated the impacts of the non-native macrophyte Crassula helmsii on macroinvertebrate assemblages in ponds in Dartmoor National Park, UK. Sampled ponds differed in the extent of invasion, being uninvaded, partially invaded and dominated by Crassula. Samples were taken from macrophyte stands using a hand net and taxa identified to the lowest taxonomic level possible in the laboratory. Assemblages were compared using univariate and multivariate approaches. Taxonomic richness and Shannon-Wiener Index did not differ significantly between invasion categories. …

Artificial Light At Night Reverses Monthly Foraging Pattern Under Simulated Moonlight, Svenja Tidau, Jack Whittle, Stuart R. Jenkins, Thomas W. Davies

School of Biological and Marine Sciences

Mounting evidence shows that artificial light at night (ALAN) alters biological processes across levels of organization, from cells to communities. Yet, the combined impacts of ALAN and natural sources of night-time illumination remain little explored. This is in part due the lack of accurate simulations of the complex changes moonlight intensity, timing and spectra throughout a single night and lunar cycles in laboratory experiments. We custom-built a novel system to simulate natural patterns of moonlight to test how different ALAN intensities affect predator–prey relationships over the full lunar cycle. Exposure to high intensity ALAN (10 and 50 lx) reversed the …

A Sampling, Exposure And Receptor Framework For Identifying Factors That Modulate Behavioural Responses To Disturbance In Cetaceans, Cormac G. Booth, Naomi Brannan, Rebecca Dunlop, Ari Friedlander, Saana Isojunno, Patrick Miller, Nicola Quick, Brandon Southall, Enrico Pirotta

School of Biological and Marine Sciences

No abstract provided.

Microplastic Ingestion In Zooplankton From The Fram Strait In The Arctic, Zara L.R. Botterell, Melanie Bergmann, Nicole Hildebrandt, Thomas Krumpen, Michael Steinke, Richard C. Thompson, Penelope K. Lindeque

School of Biological and Marine Sciences

Some of the highest microplastic concentrations in marine environments have been reported from the Fram Strait in the Arctic. This region supports a diverse ecosystem dependent on high concentrations of zooplankton at the base of the food web. Zooplankton samples were collected during research cruises using Bongo and MOCNESS nets in the boreal summers of 2018 and 2019. Using FTIR scanning spectroscopy in combination with an automated polymer identification approach, we show that all five species of Arctic zooplankton investigated had ingested microplastics. Amphipod species, found in surface waters or closely associated with sea ice, had ingested significantly more microplastic …

Examining The Generalizability Of Research Findings From Archival Data, Andrew Delios, Elena Giulia Clemente, Tao Wu, Hongbin Tan, Yong Wang, Michael Gordon, Domenico Viganola, Z Chen, Anna Dreber, Magnus Johannesson, Thomas Pfeiffer, Eric Luis Uhlmann, Al-Aziz Am Abd, Ajay T. Abraham, Jais Trojan, Matus Adamkovic, Elena Agadullina, Jungsoo Ahn, Cinla Akinci, Handan Akkas, David Albrecht, Shilaan Alzahawi, Marcio Amaral-Baptista, Rahul Anand, Kevin Francis U. Ang, Frederik Anseel, John Jamir Benzon R. Aruta, Mujeeba Ashraf, Bradley J. Baker, Xueqi Bao

School of Psychology

This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability—for the findings that proved directly reproducible, 84% emerged in other available time …

Floc Size Distributions Of Cohesive Sediment In Homogeneous Isotropic Turbulence, M Yu, X Yu, S Balachandar, Aj Manning

School of Biological and Marine Sciences

Floc size distribution is one of the key parameters to characterize flocculating cohesive sediment. An Eulerian–Lagrangian framework has been implemented to study the flocculation dynamics of cohesive sediments in homogeneous isotropic turbulent flows. Fine cohesive sediment particles are modeled as the dispersed phase by the discrete element method, which tracks the motion of individual particles. An adhesive contact model with rolling friction is applied to simulate the particle–particle interactions. By varying the physicochemical properties (i.e., stickiness and stiffness) of the primary particles, the dependence of the mathematical form of the floc size distribution on sediment properties is investigated. At the …

Brief Intervention To Reduce Fatigue Impact In Patients With Inflammatory Arthritis: Design And Outcomes Of A Single-Arm Feasibility Study, E Dures, S Bridgewater, B Abbott, J Adams, A Berry, Lm Mccracken, S Creanor, S Hewlett, J Lomax, M Ndosi, J Thorn, M Urban, P Ewings

Peninsula Medical School

ObjectivesPatients with inflammatory arthritis report that fatigue is challenging to manage. We developed a manualised, one-to-one, cognitive–behavioural intervention, delivered by rheumatology health professionals (RHPs). The Fatigue - Reducing its Effects through individualised support Episodes in Inflammatory Arthritis (FREE-IA) study tested the feasibility of RHP training, intervention delivery and outcome collection ahead of a potential trial of clinical and cost-effectiveness.MethodsIn this single-arm feasibility study, eligible patients were ≥18 years, had a clinician-confirmed diagnosis of an inflammatory arthritis and scored ≥6/10 on the Bristol Rheumatoid Arthritis Fatigue (BRAF) Numerical Rating Scale (NRS) Fatigue Effect. Following training, RHPs delivered two to four sessions …

Benthic Megafauna Of The Western Clarion-Clipperton Zone, Pacific Ocean, G Bribiesca-Contreras, Tg Dahlgren, Dj Amon, S Cairns, Et Al

School of Biological and Marine Sciences

There is a growing interest in the exploitation of deep-sea mineral deposits, particularly on the abyssal seafloor of the central Pacific Clarion-Clipperton Zone (CCZ), which is rich in polymetallic nodules. In order to effectively manage potential exploitation activities, a thorough understanding of the biodiversity, community structure, species ranges, connectivity, and ecosystem functions across a range of scales is needed. The benthic megafauna plays an important role in the functioning of deep-sea ecosystems and represents an important component of the biodiversity. While megafaunal surveys using video and still images have provided insight into CCZ biodiversity, the collection of faunal samples is …

A Systems Approach To Mapping Uk Regional Innovation Ecosystems For Policy Insight, Dan Arthur, Jonathan Moizer, Jonathan Lean

Plymouth Business School

The literature on innovation and regional economic development shows widespread references to ‘systems’ but relatively little application of systems thinking and problem structuring methods. Innovation models are thus under-theorised with operationally-based maps that link the structure of innovation systems to behaviour and possible policy levers. This conceptual paper addresses this shortfall by applying a systems mapping approach to regional innovation ecosystems which sets out the structural drivers and actor inter-relationships in regional economies with universities acting as focal points for knowledge application. A causal feedback map is hypothesised from participative research and the innovation literature, providing an integrative framework and …

Distribution And Transport Of Microplastics In Groundwater (Shiraz Aquifer, Southwest Iran), Atefeh Esfandiari, Sajjad Abbasi, Ahmad Behrouj Peely, Dariush Mowla, Mohammad Ali Ghanbarian, Patryk Oleszczuk, Andrew Turner

School of Geography, Earth and Environmental Sciences

Despite the significance of groundwater to the hydrological cycle and as a source of potable water, very little information exists on microplastics (MPs) in this environment. In the present study, MPs have been determined in ten well samples obtained from an alluvial aquifer in a semi-arid region (Shiraz, Iran) following filtration, digestion and inspection under a binocular microscope. A total of 96 MPs were identified, and concentrations ranged from 0.1 to 1.3 MP L−1 (mean and median = 0.48 and 0.43 MP L−1, respectively) and exhibited a complex distribution across the area that reflected differences in land use and local …

Lessons From Bright-Spots For Advancing Knowledge Exchange At The Interface Of Marine Science And Policy, Denis B. Karcher, Christopher Cvitanovic, Putten Ie Van, Rebecca M. Colvin, Derek Armitage, Shankar Aswani, Marta Ballesteros, Natalie C. Ban, María José Barragán-Paladines, Angela Bednarek, Johann D. Bell, Cassandra M. Brooks, Tim M. Daw, La Cruz-Modino R De, Tessa B. Francis, Elizabeth A. Fulton, Alistair J. Hobday, Draško Holcer, Charlotte Hudson, Tim C. Jennerjahn, Aimee Kinney, Maaike Knol-Kauffman, Marie F. Löf, Priscila F.M. Lopes, Peter C. Mackelworth, Abigail Mcquatters-Gollop, Ella Kari Muhl, Pita Neihapi, José J. Pascual-Fernández, Stephen M. Posner, Hens Runhaar, Keith Sainsbury, Gunnar Sander, Dirk J. Steenbergen, Paul M. Tuda, Elizabeth Whiteman, Jialin Zhang

School of Biological and Marine Sciences

Evidence-informed decision-making is in increasing demand given growing pressures on marine environments. A way to facilitate this is by knowledge exchange among marine scientists and decision-makers. While many barriers are reported in the literature, there are also examples whereby research has successfully informed marine decision-making (i.e., ‘bright-spots’). Here, we identify and analyze 25 bright-spots from a wide range of marine fields, contexts, and locations to provide insights into how to improve knowledge exchange at the interface of marine science and policy. Through qualitative surveys we investigate what initiated the bright-spots, their goals, and approaches to knowledge exchange. We also seek …

Possible Regulation Of Toll-Like Receptor 4 By Lysine Acetylation Through Lpcat2 Activity In Raw264.7 Cells., Victory Ibigo Poloamina, Wondwossen Abate, Gyorgy Fejer, Simon K. Jackson

School of Biomedical Sciences

Inflammation is central to several diseases. TLR4 mediates inflammation by recognising and binding to bacterial lipopolysaccharides and interacting with other proteins in the TLR4 signalling pathway. Although there is extensive research on TLR4-mediated inflammation, there are gaps in understanding its mechanisms. Recently, TLR4 co-localised with LPCAT2, a lysophospholipid acetyltransferase. LPCAT2 is already known to influence lipopolysaccharide-induced inflammation; however, the mechanism of LPCAT2 influencing lipopolysaccharide-mediated inflammation is not understood. This study combined computational analysis with biochemical analysis to investigate the influence of LPCAT2 on lysine acetylation in LPS-treated RAW264.7 cells. The results suggest for the first time that LPCAT2 influences lysine …

Impact Of The Salt Concentration And Biophysical Cohesion On The Settling Behavior Of Bentonites, E Krahl, B Vowinckel, L Ye, T-J Hsu, Aj Manning

School of Biological and Marine Sciences

The flocculation behavior of clay minerals in aquatic environments is an important process in estuarine and riverine dynamics, where strong gradients in salinity can locally occur. Various contradicting observations have been reported in the literature on the impact of salt concentration on the settling process of cohesive sediments. To address this issue in a systematic manner, we investigate the settling behavior of clay minerals as a function of the salt concentration of the ambient water. Specifically, we focus on montmorillonite as a prototype clay mineral with a high cation exchange capacity (CEC). To this end, we study suspensions of Wyoming …

Interrogating Intervention Delivery And Participants’ Emotional States To Improve Engagement And Implementation: A Realist Informed Multiple Case Study Evaluation Of Engager, Lauren Weston, Sarah Rybczynska-Bunt, Cath Quinn, Charlotte Lennox, Mike Maguire, Mark Pearson, Alex Stirzaker, Graham Durcan, Caroline Stevenson, Jonathan Graham, Lauren Carroll, Rebecca Greer, Mark Haddad, Rachael Hunter, Rob Anderson, Roxanne Todd, Sara Goodier, Sarah Brand, Susan Michie, Tim Kirkpatrick, Sarah Leonard, Tirril Harris, William Henley, Jenny Shaw, Christabel Owens, Richard Byng

Peninsula Medical School

Background

‘Engager’ is an innovative ‘through-the-gate’ complex care intervention for male prison-leavers with common mental health problems. In parallel to the randomised-controlled trial of Engager (Trial registration number: ISRCTN11707331), a set of process evaluation analyses were undertaken. This paper reports on the depth multiple case study analysis part of the process evaluation, exploring how a sub-sample of prison-leavers engaged and responded to the intervention offer of one-to-one support during their re-integration into the community. Methods

To understand intervention delivery and what response it elicited in individuals, we used a realist-informed qualitative multiple ‘case’ studies approach. We scrutinised how intervention component …

Ecosystem Benefits Of Adopting A Whole‐Site Approach To Mpa Management, Bede Ffinian Rowe Davies, Luke Holmes, Martin J. Attrill, Emma V. Sheehan

School of Biological and Marine Sciences

No abstract provided.

Nano‐Diagnostics As An Emerging Platform For Oral Cancer Detection: Current And Emerging Trends, D Chakraborty, D Ghosh, Sanjit Kumar, D Jenkins, N Chandrasekaran, A Mukherjee

School of Engineering, Computing and Mathematics

No abstract provided.

The Intersection Of Evolutionary Computation And Explainable Ai, J Bacardit, Aei Brownlee, S Cagnoni, Et Al

School of Engineering, Computing and Mathematics

In the past decade, Explainable Artificial Intelligence (XAI) has attracted a great interest in the research community, motivated by the need for explanations in critical AI applications. Some recent advances in XAI are based on Evolutionary Computation (EC) techniques, such as Genetic Programming. We call this trend EC for XAI. We argue that the full potential of EC methods has not been fully exploited yet in XAI, and call the community for future efforts in this field. Likewise, we find that there is a growing concern in EC regarding the explanation of population-based methods, i.e., their search process and outcomes. …

Molnupiravir Inhibits Sars-Cov-2 Variants Including Omicron In The Hamster Model, K Rosenke, Atsushi Okumura, Matthew C. Lewis, F Feldmann, Kimberly Meade-White, W. Forrest Bohler, Amanda Griffin, R Rosenke, Carl Shaia, Michael A. Jarvis, H Feldmann

School of Biomedical Sciences

The effectiveness of exercise and physical therapy for children with ataxia is poorly understood. The aim of this systematic review was to critically evaluate the range, scope and methodological quality of studies investigating the effectiveness of exercise and physical therapy interventions for children with ataxia. The following databases were searched: AMED, CENTRAL, CDSR, CINAHL, ClinicalTrials.gov, EMBASE, Ovid MEDLINE, PEDro and Web of Science. No limits were placed on language, type of study or year of publication. Two reviewers independently determined whether the studies met the inclusion criteria, extracted all relevant outcomes, and conducted methodological quality assessments. A total of 1988 …

Comprehensive Short And Long Read Sequencing Analysis For The Gaucher And Parkinson's Disease-Associated Gba Gene., Marco Toffoli, Xiao Chen, Fritz J. Sedlazeck, Chiao Yin Lee, Stephen Mullin, Abigail Higgins, Sofia Koletsi, Monica Emili Garcia-Segura, Esther Sammler, Sonja W. Scholz, Anthony H.V. Schapira, Michael A. Eberle, Christos Proukakis

Peninsula Medical School

GBA variants carriers are at increased risk of Parkinson's disease (PD) and Lewy body dementia (LBD). The presence of pseudogene GBAP1 predisposes to structural variants, complicating genetic analysis. We present two methods to resolve recombinant alleles and other variants in GBA: Gauchian, a tool for short-read, whole-genome sequencing data analysis, and Oxford Nanopore sequencing after PCR enrichment. Both methods were concordant for 42 samples carrying a range of recombinants and GBAP1-related mutations, and Gauchian outperformed the GATK Best Practices pipeline. Applying Gauchian to sequencing of over 10,000 individuals shows that copy number variants (CNVs) spanning GBAP1 are relatively common in …

Bi-Allelic Variants In Wnt7b Disrupt The Development Of Multiple Organs In Humans, Jdc Pereira Baptista

Peninsula Medical School

BackgroundPulmonary hypoplasia, Diaphragmatic anomalies, Anophthalmia/microphthalmia and Cardiac defects delineate the PDAC syndrome. We aim to identify the cause of PDAC syndrome in patients who do not carry pathogenic variants in RARB and STRA6, which have been previously associated with this disorder.MethodsWe sequenced the exome of patients with unexplained PDAC syndrome and performed functional validation of candidate variants.ResultsWe identified bi-allelic variants in WNT7B in fetuses with PDAC syndrome from two unrelated families. In one family, the fetus was homozygous for the c.292C>T (p.(Arg98*)) variant whereas the fetuses from the other family were compound heterozygous for the variants c.225C>G (p.(Tyr75*)) …

An Autonomous Sailboat For Environment Monitoring, Y-T Ang, W-K Ng, Y-W Chong, Et Al

School of Biological and Marine Sciences

The marine environment is constantly at risk from coastal urbanization. The deterioration of coastal and marine environments is evidenced by the decline of mangroves and the biodiversity of such environments and increasing recurrences of algal and jellyfish blooms. There is a lack of environmental data especially in developing countries such as Malaysia to determine the sustainability and impact of the current development on coastal resources. We developed an autonomous sailboat that utilizes the Internet of things technology to collect and analyze ocean water quality data for local authorities to obtain insights into the sustainable development of coastal resources. The USV …

Sentience In Decapods: An Open Question, Mark Briffa

School of Biological and Marine Sciences

No abstract provided.

Building Bridges Between Natural And Social Science Disciplines: A Standardized Methodology To Combine Data On Ecosystem Quality Trends, I. Richter, B. R. Roberts, S. F. Sailley, E. Sullivan, V. V. Cheung, J. Eales, M. Fortnam, J. B. Jontila, C. Maharja, T. Ha Nguyen, S. Pahl, R. A. Praptiwi, J. Sugardjito, J. D.C. Sumeldan, W. M. Syazwan, A. Y. Then, M. C. Austen

School of Psychology

Despite a growing interest in interdisciplinary research, systematic ways of how to integrate data from different disciplines are still scarce. We argue that successful resource management relies on two key data sources: natural science data, which represents ecosystem structure and processes, and social science data, which describes people's perceptions and understanding. Both are vital, mutually complementing information sources that can underpin the development of feasible and effective policies and management interventions. To harvest the added value of combined knowledge, a uniform scaling system is needed. In this paper, we propose a standardized methodology to connect and explore different types of …

Optimising Curve Fitting Techniques To Look For Standardisation Of The Analysis Of Defocus Curves Derived From Multifocal Intraocular Lenses, Elizabeth M. Law, Hd Buckhurst, Rajesh K. Aggarwal, H El‐Kasaby, Jonathan Marsden, Gary L. Shum, Pj Buckhurst

School of Health Professions

IntroductionTo establish the most appropriate curve fitting method to allow accurate comparison of defocus curves derived from intraocular lenses (IOLs).MethodsDefocus curves were plotted in five IOL groups (monofocal, extended depth of focus, refractive bifocal, diffractive bifocal and trifocal). Polynomial curves from 2nd to 11th order and cubic splines were fitted. Goodness of fit (GOF) was assessed using five methods: least squares, coefficient of determination (R2adj), Akaike information criteria (AIC), visual inspection and Snedecor and Cochran. Additional defocus steps at −2.25 D and −2.75 D were measured and compared to the calculated visual acuity (VA) values. Area under the defocus curve …

Acute Bioenergetic Insulin Sensitivity Of Skeletal Muscle Cells: Atp-Demand-Provoked Glycolysis Contributes To Stimulation Of Atp Supply, R.A. Donnell, J.E. Carré, C. Affourtit

School of Biomedical Sciences

Skeletal muscle takes up glucose in an insulin-sensitive manner and is thus important for the maintenance of blood glucose homeostasis. Insulin resistance during development of type 2 diabetes is associated with decreased ATP synthesis, but the causality of this association is controversial. In this paper, we report real-time oxygen uptake and medium acidification data that we use to quantify acute insulin effects on intracellular ATP supply and ATP demand in rat and human skeletal muscle cells. We demonstrate that insulin increases overall cellular ATP supply by stimulating the rate of glycolytic ATP synthesis. Stimulation is immediate and achieved directly by …

Reduced Range Size And Important Bird And Biodiversity Area Coverage For The Harpy Eagle ( Harpia Harpyja ) Predicted From Multiple Climate Change Scenarios, Luke J. Sutton, David L. Anderson, Miguel Franco, Christopher J.W. Mcclure, Everton B.P. Miranda, F. Hernán Vargas, F. Hernán Vargas, Robert Puschendorf

School of Biological and Marine Sciences

No abstract provided.

Biomarkers Of Nanomaterials Hazard From Multi-Layer Data, V Fortino, Pas Kinaret, M Fratello, A Serra, La Saarimäki, A Gallud, G Gupta, G Vales, M Correia, O Rasool, J Ytterberg, M Monopoli, T Skoog, P Ritchie, S Moya, S Vázquez-Campos, R Handy, R Grafström, L Tran, R Zubarev, R Lahesmaa, K Dawson, K Loeschner, Eh Larsen, F Krombach, H Norppa, J Kere, K Savolainen, H Alenius, B Fadeel, D Greco

School of Biological and Marine Sciences

AbstractThere is an urgent need to apply effective, data-driven approaches to reliably predict engineered nanomaterial (ENM) toxicity. Here we introduce a predictive computational framework based on the molecular and phenotypic effects of a large panel of ENMs across multiple in vitro and in vivo models. Our methodology allows for the grouping of ENMs based on multi-omics approaches combined with robust toxicity tests. Importantly, we identify mRNA-based toxicity markers and extensively replicate them in multiple independent datasets. We find that models based on combinations of omics-derived features and material intrinsic properties display significantly improved predictive accuracy as compared to physicochemical properties …

A Roadmap To Advance Marine And Coastal Monitoring, Biodiversity Assessment, And International Reporting: A Developing Nation Perspective, Kaylee P. Smit, Niekerk L Van, Linda R. Harris, Abigail Mcquatters-Gollop, Lynne J. Shannon, Kerry J. Sink

School of Biological and Marine Sciences

Despite the increasing number of tools and indicators to measure biodiversity status and trends, many developing countries struggle to initiate and advance coastal and marine assessments needed to monitor and track national and international progress in biodiversity targets. We identified five key challenges that hinder progress in this context, based on a national marine assessment workshop held in South Africa, and developed recommendations and tangible actions to address these challenges drawing from multiple national assessments, regional initiatives, and global collaborations over the last 15 years. Challenges include a poor understanding of methods, limited capacity and funding for assessments, a lack …

Priorities For Ocean Microbiome Research, Andre Abreu, Etienne Bourgois, Adam Gristwood, Romain Troublé, Silvia G. Acinas, Peer Bork, Emmanuel Boss, Chris Bowler, Marko Budinich, Samuel Chaffron, Vargas C De, Tom O. Delmont, Damien Eveillard, Lionel Guidi, Daniele Iudicone, Stephanie Kandels, Hélène Morlon, Fabien Lombard, Rainer Pepperkok, Juan José Pierella Karlusich, Gwenael Piganeau, Antoine Régimbeau, Guilhem Sommeria-Klein, Lars Stemmann, Matthew B. Sullivan, Shinichi Sunagawa, Patrick Wincker, Olivier Zablocki, Detlev Arendt, Josipa Bilic, Robert Finn, Edith Heard, Brendan Rouse, Jessica Vamathevan, Raffaella Casotti, Ibon Cancio, Michael Cunliffe, Anne Emmanuelle Kervella, Wiebe H.C.F. Kooistra, Matthias Obst, Nicolas Pade, Deborah M. Power, Ioulia Santi, Tatiana Margo Tsagaraki, Jan Vanaverbeke

School of Biological and Marine Sciences

Microbial communities have essential roles in ocean ecology and planetary health. Microbes participate in nutrient cycles, remove huge quantities of carbon dioxide from the air and support ocean food webs. The taxonomic and functional diversity of the global ocean microbiome has been revealed by technological advances in sampling, DNA sequencing and bioinformatics. A better understanding of the ocean microbiome could underpin strategies to address environmental and societal challenges, including achievement of multiple Sustainable Development Goals way beyond SDG 14 'life below water'. We propose a set of priorities for understanding and protecting the ocean microbiome, which include delineating interactions between …