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Make A Difference: Choose Artificial Reefs Over Natural Reefs To Compensate For The Environmental Impacts Of Dive Tourism, Louise B. Firth, Mark Farnworth, Keiron P.P. Fraser, Abigail Mcquatters-Gollop Nov 2023

Make A Difference: Choose Artificial Reefs Over Natural Reefs To Compensate For The Environmental Impacts Of Dive Tourism, Louise B. Firth, Mark Farnworth, Keiron P.P. Fraser, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

In the marine environment, natural reef habitats are amongst the most threatened by human activities. Although reef-based ecotourism can benefit local economies, dive tourism can damage sensitive habitats. One solution to managing conflicts between the economic value of diving and its ecological threats is the deployment of artificial reefs near popular dive sites. We surveyed recreational divers to assess divers' use, preference, and perceptions of diving artificial versus natural sites. We found that more divers prefer to dive in natural than artificial habitats, with associated biodiversity the most popular reason for preferring natural habitats, and appreciating shipwrecks the most popular …


Clostridioides Difficile Spores Tolerate Disinfection With Sodium Hypochlorite Disinfectant And Remain Viable Within Surgical Scrubs And Gown Fabrics, Humaira Ahmed, Lovleen Tina Joshi Nov 2023

Clostridioides Difficile Spores Tolerate Disinfection With Sodium Hypochlorite Disinfectant And Remain Viable Within Surgical Scrubs And Gown Fabrics, Humaira Ahmed, Lovleen Tina Joshi

Peninsula Dental School

Clostridioides difficile is the most common cause of antibiotic-associated diarrhoea globally. Its spores have been implicated in the prevalence of C. difficile infection due to their resistance and transmission ability between surfaces. Currently, disinfectants such as chlorine-releasing agents (CRAs) and hydrogen peroxide are used to decontaminate and reduce the incidence of infections in clinical environments. Our previous research demonstrated the ability of C. difficile spores to survive exposure to recommended concentrations of sodium dichloroisocyanurate in liquid form and within personal protective fabrics such as surgical gowns; however, the present study examined the spore response to clinical in-use concentrations of sodium …


Editorial: Physiology Of Invertebrate Sensing In Extreme Conditions And Hostile Environment, Michele Cesari, Chiara Boschetti, Thomas C. Boothby Nov 2023

Editorial: Physiology Of Invertebrate Sensing In Extreme Conditions And Hostile Environment, Michele Cesari, Chiara Boschetti, Thomas C. Boothby

School of Biological and Marine Sciences

No abstract provided.


Indoor Air Quality In Cob Buildings: In Situ Studies And Artificial Neural Network Modeling, K Touati, M-H Benzaama, Mendili Y El, Guern M Le, F Streiff, S Goodhew Nov 2023

Indoor Air Quality In Cob Buildings: In Situ Studies And Artificial Neural Network Modeling, K Touati, M-H Benzaama, Mendili Y El, Guern M Le, F Streiff, S Goodhew

School of Art, Design and Architecture

Knowledge of indoor air quality (IAQ) in cob buildings during the first few months following their delivery is of vital importance in preventing occupants’ health problems. The present research focuses on evaluating IAQ in cob buildings through a prototype built in Normandy, France. To achieve this, the prototype was equipped with a set of sensors to monitor various parameters that determine indoor and outdoor air quality. These parameters include relative humidity (RH), carbon dioxide (CO2), nitrogen dioxide (NO2), ozone (O3), particulate matter (PM1 and PM10), and volatile organic compounds (VOCs). The obtained experimental results indicate that, overall, there is good …


A Pragmatic Randomized Controlled Exploratory Trial Of The Effectiveness Of Eye Movement Desensitization And Reprocessing Therapy For Psychotic Disorder, Simon Marlow, Richard Laugharne, Jon Allard, Paul Bassett, Stefan Priebe, Joanne Ledger, Jacqueline Kerr, Deborah Priest, Alje Vanhoorn, Cailin Boland, Rohit Shankar Nov 2023

A Pragmatic Randomized Controlled Exploratory Trial Of The Effectiveness Of Eye Movement Desensitization And Reprocessing Therapy For Psychotic Disorder, Simon Marlow, Richard Laugharne, Jon Allard, Paul Bassett, Stefan Priebe, Joanne Ledger, Jacqueline Kerr, Deborah Priest, Alje Vanhoorn, Cailin Boland, Rohit Shankar

Peninsula Medical School

Background: People with severe mental illness are often excluded from trials related to Eye Movement Desensitization and Reprocessing (EMDR) therapy. Principal concerns are that they may not tolerate treatment, might risk relapse or that psychotic symptoms may worsen. There is however building evidence of a traumatogenic etiology of psychotic disorder that may benefit therapeutically from EMDR. However, EMDR in this role is done mainly in specialist tertiary settings. Aim: To conduct a randomized exploratory trial of prospective treatment of EMDR for people with psychotic disorder and a history of trauma in an adult community mental health service. Methods: A randomized …


Moving From Symptom Management To Upstream Plastics Prevention: The Fallacy Of Plastic Cleanup Technology, Melanie Bergmann, Hans Peter H. Arp, Bethanie Carney Almroth, Win Cowger, Marcus Eriksen, Tridibesh Dey, Sedat Gündoğdu, Rebecca R. Helm, Anja Krieger, Kristian Syberg, Mine B. Tekman, Richard C. Thompson, Patricia Villarrubia-Gómez, Anish Kumar Warrier, Trisia Farrelly Nov 2023

Moving From Symptom Management To Upstream Plastics Prevention: The Fallacy Of Plastic Cleanup Technology, Melanie Bergmann, Hans Peter H. Arp, Bethanie Carney Almroth, Win Cowger, Marcus Eriksen, Tridibesh Dey, Sedat Gündoğdu, Rebecca R. Helm, Anja Krieger, Kristian Syberg, Mine B. Tekman, Richard C. Thompson, Patricia Villarrubia-Gómez, Anish Kumar Warrier, Trisia Farrelly

School of Biological and Marine Sciences

Plastic removal technologies can temporarily mitigate plastic accumulation at local scales, but evidence-based criteria are needed in policies to ensure that they are feasible and that ecological benefits outweigh the costs. To reduce plastic pollution efficiently and economically, policy should prioritize regulating and reducing upstream production rather than downstream pollution cleanup.


Response Of Co2 And Ch4 Emissions From Arctic Tundra Soils To A Multifactorial Manipulation Of Water Table, Temperature And Thaw Depth, K Best, D Zona, E Briant, C-T Lai, Da Lipson, Kr Mcewing, Sj Davidson, Wc Oechel Nov 2023

Response Of Co2 And Ch4 Emissions From Arctic Tundra Soils To A Multifactorial Manipulation Of Water Table, Temperature And Thaw Depth, K Best, D Zona, E Briant, C-T Lai, Da Lipson, Kr Mcewing, Sj Davidson, Wc Oechel

School of Geography, Earth and Environmental Sciences

Significant uncertainties persist concerning how Arctic soil tundra carbon emission responds to environmental changes. In this study, 24 cores were sampled from drier (high centre polygons and rims) and wetter (low centre polygons and troughs) permafrost tundra ecosystems. We examined how soil CO2 and CH4 fluxes responded to laboratory-based manipulations of soil temperature (and associated thaw depth) and water table depth, representing current and projected conditions in the Arctic. Similar soil CO2 respiration rates occurred in both the drier and the wetter sites, suggesting that a significant proportion of soil CO2 emission occurs via anaerobic respiration under water-saturated conditions in …


Urinary Tract Infections: A Review Of The Current Diagnostics Landscape, Braith Grey, Mathew Upton, Lovleen Tina Joshi Nov 2023

Urinary Tract Infections: A Review Of The Current Diagnostics Landscape, Braith Grey, Mathew Upton, Lovleen Tina Joshi

School of Biomedical Sciences

Urinary tract infections are the most common bacterial infections worldwide. Infections can range from mild, recurrent (rUTI) to complicated (cUTIs), and are predominantly caused by uropathogenic Escherichia coli (UPEC). Antibiotic therapy is important to tackle infection; however, with the continued emergence of antibiotic resistance there is an urgent need to monitor the use of effective antibiotics through better stewardship measures. Currently, clinical diagnosis of UTIs relies on empiric methods supported by laboratory testing including cellular analysis (of both human and bacterial cells), dipstick analysis and phenotypic culture. Therefore, development of novel, sensitive and specific diagnostics is an important means to …


Plastics And The Environment, I. E. Napper, R. C. Thompson Nov 2023

Plastics And The Environment, I. E. Napper, R. C. Thompson

School of Biological and Marine Sciences

Plastics are persistent and pervasive throughout the environment and have now been reported from the deepest parts of the ocean to the tops of the highest and most remote mountains. There is a body of information on the sources, degradation, and transport of plastics as well as a variety of research investigating the ecotoxicological and wider ecological consequences of plastic ingestion and accumulation. Such knowledge has been obtained with developments in field and laboratory methods for plastic identification and then well-publicized in the media and wider public communications. However, although there has been a large focus on plastic pollution within …


Archaeology In 2022: Counter‐Myths For Hopeful Futures, M Berihuete‐Azorín, Chelsea Blackmore, Lewis Borck, James L. Flexner, Catherine J. Frieman, Corey A. Herrmann, Rachael Kiddey Nov 2023

Archaeology In 2022: Counter‐Myths For Hopeful Futures, M Berihuete‐Azorín, Chelsea Blackmore, Lewis Borck, James L. Flexner, Catherine J. Frieman, Corey A. Herrmann, Rachael Kiddey

School of Law, Humanities and Social Sciences

Archaeology in 2022 features more calls than ever for a socially and politically engaged, progressive discipline. Archaeologists increasingly respect and integrate decolonizing and Indigenous knowledge in theory and practice. They acknowledge and embrace the fluidity and diversity of sexes and genders, past and present. They document patterns of migration, ancient as well as contemporary, to combat retrograde and racist narratives that remain pervasive in the public sphere. At the same time, the field has a deep‐seated conservative bastion toward which many scholars retreat, arguing for an “objective” past that is free of political implications or interpretive ambiguity. As anarchist archaeologists, …


Major Declines In Ne Atlantic Plankton Contrast With More Stable Populations In The Rapidly Warming North Sea, Matthew M. Holland, Arnaud Louchart, Luis Felipe Artigas, Clare Ostle, Angus Atkinson, Isabelle Rombouts, Carolyn A. Graves, Michelle Devlin, Birgit Heyden, Margarita Machairopoulou, Eileen Bresnan, Jos Schilder, Hans H. Jakobsen, Hannah Llody-Hartley, Paul Tett, Mike Best, Eric Goberville, Abigail Mcquatters-Gollop Nov 2023

Major Declines In Ne Atlantic Plankton Contrast With More Stable Populations In The Rapidly Warming North Sea, Matthew M. Holland, Arnaud Louchart, Luis Felipe Artigas, Clare Ostle, Angus Atkinson, Isabelle Rombouts, Carolyn A. Graves, Michelle Devlin, Birgit Heyden, Margarita Machairopoulou, Eileen Bresnan, Jos Schilder, Hans H. Jakobsen, Hannah Llody-Hartley, Paul Tett, Mike Best, Eric Goberville, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

Plankton form the base of marine food webs, making them important indicators of ecosystem status. Changes in the abundance of plankton functional groups, or lifeforms, can affect higher trophic levels and can indicate important shifts in ecosystem functioning. Here, we extend this knowledge by combining data from Continuous Plankton Recorder and fixed-point stations to provide the most comprehensive analysis of plankton time-series for the North-East Atlantic and North-West European shelf to date. We analysed 24 phytoplankton and zooplankton datasets from 15 research institutions to map 60-year abundance trends for 8 planktonic lifeforms. Most lifeforms decreased in abundance (e.g. dinoflagellates: −5 …


Breakdown Of Category-Specific Word Representations In A Brain-Constrained Neurocomputational Model Of Semantic Dementia, Yury Shtyrov, Aleksei Efremov, Anastasia Kuptsova, Thomas Wennekers, Boris Gutkin, Max Garagnani Nov 2023

Breakdown Of Category-Specific Word Representations In A Brain-Constrained Neurocomputational Model Of Semantic Dementia, Yury Shtyrov, Aleksei Efremov, Anastasia Kuptsova, Thomas Wennekers, Boris Gutkin, Max Garagnani

School of Engineering, Computing and Mathematics

The neurobiological nature of semantic knowledge, i.e., the encoding and storage of conceptual information in the human brain, remains a poorly understood and hotly debated subject. Clinical data on semantic deficits and neuroimaging evidence from healthy individuals have suggested multiple cortical regions to be involved in the processing of meaning. These include semantic hubs (most notably, anterior temporal lobe, ATL) that take part in semantic processing in general as well as sensorimotor areas that process specific aspects/categories according to their modality. Biologically inspired neurocomputational models can help elucidate the exact roles of these regions in the functioning of the semantic …


Social Workers And Acquired Brain Injury: A Systematic Review Of The Current Evidence-Base., Mark A. Linden, Mark Holloway, Claire Cooper, Akudo Amadiegwu, Caroline Bald, Michael Clark, Andy Mantell, Alyson Norman, Andrew Bateman Nov 2023

Social Workers And Acquired Brain Injury: A Systematic Review Of The Current Evidence-Base., Mark A. Linden, Mark Holloway, Claire Cooper, Akudo Amadiegwu, Caroline Bald, Michael Clark, Andy Mantell, Alyson Norman, Andrew Bateman

School of Psychology

Social work plays an important role in the assessment and treatment of people with acquired brain injury. Acquired brain injury is a complex and highly prevalent condition which can impact on cognitive, emotional and social domains. As acquired brain injury is a hidden disability it can be misdiagnosed or classified as another condition entirely. We sought to systematically explore the evidence base to examine how social workers have been prepared to work with their clients with brain injury. Employing six electronic databases (Social Policy & Practice, Web of Science, Scopus, PubMed, PsycINFO, CINAHL Plus) we reviewed 1071 papers. After applying …


Substantial Light Woodland And Open Vegetation Characterised The Temperate Forest Biome Before Homo Sapiens, Elena A. Pearce, Florence Mazier, Signe Normand, Ralph Fyfe, Valérie Andrieu, Corrie Bakels, Zofia Balwierz, K Binka, Steve Boreham, Olga K. Borisova, Anna Brostrom, Beaulieu J-L De, Cunhai Gao, P Gonzalez-Samperiz, Wojciech Granoszewski, Anna Hrynowiecka, P Kolaczek, P Kunes, Donatella Magri, Małgorzata Malkiewicz, T Highall, Alice M. Milner, P Moller, Małgorzata Nita, Bożena Noryśkiewicz, Irena Agnieszka Pidek, Maurice Reille, Ann Marie Robertsson, J. Sakari Salonen, Patrick Schläfli, Jeroen Schokker, Paolo Scussolini, Vaida Šeirienė, Jaqueline Strahl, Brigitte Urban, Hanna Winter, Jens Christian Svenning Nov 2023

Substantial Light Woodland And Open Vegetation Characterised The Temperate Forest Biome Before Homo Sapiens, Elena A. Pearce, Florence Mazier, Signe Normand, Ralph Fyfe, Valérie Andrieu, Corrie Bakels, Zofia Balwierz, K Binka, Steve Boreham, Olga K. Borisova, Anna Brostrom, Beaulieu J-L De, Cunhai Gao, P Gonzalez-Samperiz, Wojciech Granoszewski, Anna Hrynowiecka, P Kolaczek, P Kunes, Donatella Magri, Małgorzata Malkiewicz, T Highall, Alice M. Milner, P Moller, Małgorzata Nita, Bożena Noryśkiewicz, Irena Agnieszka Pidek, Maurice Reille, Ann Marie Robertsson, J. Sakari Salonen, Patrick Schläfli, Jeroen Schokker, Paolo Scussolini, Vaida Šeirienė, Jaqueline Strahl, Brigitte Urban, Hanna Winter, Jens Christian Svenning

School of Geography, Earth and Environmental Sciences

The extent of vegetation openness in past European landscapes is widely debated. In particular, the temperate forest biome has traditionally been defined as dense, closed-canopy forest; however, some argue that large herbivores maintained greater openness or even wood-pasture conditions. Here, we address this question for the Last Interglacial period (129,000–116,000 years ago), before Homo sapiens–linked megafauna declines and anthropogenic landscape transformation. We applied the vegetation reconstruction method REVEALS to 96 Last Interglacial pollen records. We found that light woodland and open vegetation represented, on average, more than 50% cover during this period. The degree of openness was highly variable and …


Enabling Interdisciplinary Research Capacity For Sustainable Development: Self- Evaluation Of The Blue Communities Project In The Uk And Southeast Asia, F Culhane, V Cheung, M Austen Nov 2023

Enabling Interdisciplinary Research Capacity For Sustainable Development: Self- Evaluation Of The Blue Communities Project In The Uk And Southeast Asia, F Culhane, V Cheung, M Austen

School of Biological and Marine Sciences

No abstract provided.


The Potential For Medicinal Cannabis To Help Manage Challenging Behaviour In People With Intellectual Disability: A Perspective Review, Laura Korb, Samuel Tromans, Bhathika Perera, Nagina Khan, Lisa Burrows, Richard Laugharne, Angela Hassiotis, Victoria Allgar, Daryl Efron, Ian Maidment, Rohit Shankar Nov 2023

The Potential For Medicinal Cannabis To Help Manage Challenging Behaviour In People With Intellectual Disability: A Perspective Review, Laura Korb, Samuel Tromans, Bhathika Perera, Nagina Khan, Lisa Burrows, Richard Laugharne, Angela Hassiotis, Victoria Allgar, Daryl Efron, Ian Maidment, Rohit Shankar

Peninsula Medical School

Background: Around 2% of the population have intellectual disabilities. Over one-third people with intellectual disabilities (PwID) present with ‘challenging behaviour’, which nosologically and diagnostically is an abstract concept. Challenging behaviour is influenced by a range of bio-psycho-social factors in a population, which is unable to suitably comprehend and/or communicate concerns. This predisposes to poor health and social outcomes. There is no evidence-based treatments for managing challenging behaviour. Cannabidiol (CBD) and tetrahydrocannabinol (THC) are being trialled for a range of disorders, which are over-represented in PwID and provoke challenging behaviours, such as severe epilepsy, spasticity, post-traumatic stress disorder, social phobia, pain, …


Is There Clarity On The Horizon For Peri‐Operative Oxygen Therapy?, D. Martin, A. Cumpstey Nov 2023

Is There Clarity On The Horizon For Peri‐Operative Oxygen Therapy?, D. Martin, A. Cumpstey

Peninsula Medical School

No abstract provided.


Evaluating The Relative Pollen Productivity Estimates Using The Reveals Model: A Case Study From The Cultural Landscape In Shandong, China, Furong Li, Marie José Gaillard, Siqi Xie, Qiaoyu Cui, Ralph Fyfe, Laurent Marquer, Shinya Sugita Nov 2023

Evaluating The Relative Pollen Productivity Estimates Using The Reveals Model: A Case Study From The Cultural Landscape In Shandong, China, Furong Li, Marie José Gaillard, Siqi Xie, Qiaoyu Cui, Ralph Fyfe, Laurent Marquer, Shinya Sugita

School of Geography, Earth and Environmental Sciences

The Landscape Reconstruction Algorithm (LRA) is regarded as the soundest approach for quantifying taxon-specific plant cover from pollen data. The reliability of relative pollen productivity (RPP) estimates is fundamental in the accuracy of quantitative vegetation reconstruction using the LRA approach. Inconsistent RPP estimates produced by different studies can cast doubt on the reliability and applicability of quantitative vegetation reconstruction. Therefore, it is crucial that the RPP estimates are evaluated before being applied for quantitative vegetation reconstruction. We have tested two alternative approaches, namely, a leave-one-out cross-validation (LOO) method and a splitting-by-subregion strategy, using surface pollen assemblages and the REVEALS model—the …


Comparative Phenomics: A New Approach To Study Heterochrony, Jamie C.S. Mccoy, John I. Spicer, Simon D. Rundle, Oliver Tills Nov 2023

Comparative Phenomics: A New Approach To Study Heterochrony, Jamie C.S. Mccoy, John I. Spicer, Simon D. Rundle, Oliver Tills

School of Biological and Marine Sciences

Understanding the links between development and evolution is one of the major challenges of biology. ‘Heterochronies’, evolutionary alterations in the timings of development are posited as a key mechanism of evolutionary change, but their quantification requires gross simplification of organismal development. Consequently, how changes in event timings influence development more broadly is poorly understood. Here, we measure organismal development as spectra of energy in pixel values of video, creating high-dimensional landscapes integrating development of all visible form and function. This approach we termed ‘Energy proxy traits’ (EPTs) is applied alongside previously identified heterochronies in three freshwater pulmonate molluscs (Lymnaea stagnalis, …


Polyrhythmic Modelling Of Non-Isochronous And Microtiming Patterns, G Sioros Nov 2023

Polyrhythmic Modelling Of Non-Isochronous And Microtiming Patterns, G Sioros

School of Art, Design and Architecture

Computational models and analyses of musical rhythms are predominantly based on the subdivision of durations down to a common isochronous pulse, which plays a fundamental structural role in the organization of their durational patterns. Meter, the most widespread example of such a temporal scheme, consists of several hierarchically organized pulses. Deviations from isochrony found in musical patterns are considered to form an expressive, micro level of organization that is distinct from the structural macro-organization of the basic pulse. However, polyrhythmic structures, such as those found in music from West Africa or the African diaspora, challenge both the hierarchical subdivision of …


Insights From The First Brazilian Symposium On Human Biometeorology, E Krüger, Acds Gomes, Ps Lucio, Jpa Gobo, As Nedel, Flt Gonçalves, M Piacenti-Silva, Cd Napoli, Ckc Lam Nov 2023

Insights From The First Brazilian Symposium On Human Biometeorology, E Krüger, Acds Gomes, Ps Lucio, Jpa Gobo, As Nedel, Flt Gonçalves, M Piacenti-Silva, Cd Napoli, Ckc Lam

School of Geography, Earth and Environmental Sciences

A current systematic literature review has stated several deficiencies and knowledge gaps in biometeorology research conducted in Brazil. This finding encouraged a group of local professionals in the field to foster research initiatives in topics and regions yet unexplored in the country. Motivated by that, the group organized the first Brazilian Symposium on Human Biometeorology between July 4 and 8, 2022, in Natal (RN), northeastern Brazil. This paper aims to summarize the main studies presented at the symposium and highlight a few ideas that could be pursued next in human biometeorology in future research initiatives.


Gelation Of Cytoplasmic Expanded Cag Rna Repeats Suppresses Global Protein Synthesis, Yuyin Pan, J Lu, Xinran Feng, S Lu, Y Yang, G Yang, Shudan Tan, Liang Wang, Pilong Li, Shouqing Luo, B Lu Nov 2023

Gelation Of Cytoplasmic Expanded Cag Rna Repeats Suppresses Global Protein Synthesis, Yuyin Pan, J Lu, Xinran Feng, S Lu, Y Yang, G Yang, Shudan Tan, Liang Wang, Pilong Li, Shouqing Luo, B Lu

Peninsula Medical School

RNA molecules with the expanded CAG repeat (eCAGr) may undergo sol–gel phase transitions, but the functional impact of RNA gelation is completely unknown. Here, we demonstrate that the eCAGr RNA may form cytoplasmic gel-like foci that are rapidly degraded by lysosomes. These RNA foci may significantly reduce the global protein synthesis rate, possibly by sequestering the translation elongation factor eEF2. Disrupting the eCAGr RNA gelation restored the global protein synthesis rate, whereas enhanced gelation exacerbated this phenotype. eEF2 puncta were significantly enhanced in brain slices from a knock-in mouse model and from patients with Huntington’s disease, which is a CAG …


Filling The Data Gaps: Transferring Models From Data-Rich To Data-Poor Deep-Sea Areas To Support Spatial Management, Amelia E.H. Bridges, David K.A. Barnes, James B. Bell, Rebecca E. Ross, Lizette Voges, Kerry L. Howell Nov 2023

Filling The Data Gaps: Transferring Models From Data-Rich To Data-Poor Deep-Sea Areas To Support Spatial Management, Amelia E.H. Bridges, David K.A. Barnes, James B. Bell, Rebecca E. Ross, Lizette Voges, Kerry L. Howell

School of Biological and Marine Sciences

Spatial management of the deep sea is challenging due to limited available data on the distribution of species and habitats to support decision making. In the well-studied North Atlantic, predictive models of species distribution and habitat suitability have been used to fill data gaps and support sustainable management. In the South Atlantic and other poorly studied regions, this is not possible due to a massive lack of data. In this study, we investigated whether models constructed in data-rich areas can be used to inform data-poor regions (with otherwise similar environmental conditions). We used a novel model transfer approach to identify …


Body Reprogramming For Fibromyalgia And Central Sensitivity Syndrome: A Preliminary Evaluation, Joseph W. Lanario, Esther Hudson, Cosima Locher, Annily Dee, Kerry Elliot, Anthony F. Davies Oct 2023

Body Reprogramming For Fibromyalgia And Central Sensitivity Syndrome: A Preliminary Evaluation, Joseph W. Lanario, Esther Hudson, Cosima Locher, Annily Dee, Kerry Elliot, Anthony F. Davies

More Faculty of Health Research

Objectives: Central sensitivity syndrome disorders such as fibromyalgia, provoke continued debate, highlighting diagnostic and therapeutic uncertainty. The Hyland model provides a way of understanding and treating the medically unexplained symptoms of central sensitivity syndromes using complexity theory and principles of adaption in network systems. The body reprogramming is a multi-modal intervention based on the Hyland model designed for patients living with medically unexplained symptoms. This preliminary, naturalistic and single-arm service evaluation set out to evaluate outcome after attending a body reprogramming course in patients living with fibromyalgia or central sensitivity syndrome. Methods: Patients diagnosed with fibromyalgia or central sensitivity syndrome …


Jak3 Inhibition Regulates Stemness And Thereby Controls Glioblastoma Pathogenesis, William Smedley, Amiya Patra Oct 2023

Jak3 Inhibition Regulates Stemness And Thereby Controls Glioblastoma Pathogenesis, William Smedley, Amiya Patra

Peninsula Medical School

Glioblastoma multiforme (GBM) is the most deadly brain tumor, effective treatment options for which still remain elusive. The current treatment procedure of maximal resection followed by chemotherapy has proved to be grossly insufficient to prevent disease progression and death. Despite best efforts, the maximum survival post-diagnosis is a mere 1.5 years. Therefore, there is a huge unmet clinical need to find effective therapeutic procedures to prevent the pathogenesis and relapse of GBM. Small-molecule inhibitors of signaling pathways are an attractive option to prevent various types of tumors. However, no effective small-molecule inhibitors have been successful against GBM in clinical trials. …


Synergistic Effects Of Applying Potassium Nitrate Spray With Putrescine On Productivity And Fruit Quality Of Mango Trees Cv. Ewais, Abdullah Alebidi, Mahmoud Abdel-Sattar, Laila Y. Mostafa, Alhussein S.A. Hamad, Hail Z. Rihan Oct 2023

Synergistic Effects Of Applying Potassium Nitrate Spray With Putrescine On Productivity And Fruit Quality Of Mango Trees Cv. Ewais, Abdullah Alebidi, Mahmoud Abdel-Sattar, Laila Y. Mostafa, Alhussein S.A. Hamad, Hail Z. Rihan

School of Biological and Marine Sciences

The current investigation represents of the synergistic effects of application of potassium nitrate (KNO3) in combination with putrescine (Put) on flowering, productivity, and fruit quality on Ewais mango (Mangifera indica L.) trees during the seasons 2021/2022 and 2022/2023. The selected trees were sprayed at three different stages, including flower bud differentiation, full bloom, and beginning of the fruit set, with one of the following treatments: control, 2% KNO3, 4% KNO3, 50 ppm Put, 75 ppm Put, 2% KNO3 + 50 ppm Put, 2% KNO3 + 75 ppm Put, 4% KNO3 + 50 ppm Put, 4% KNO3 + 75 ppm Put. …


The Moxfo Initiative – Study Design: Considerations Related To Study Design And Methodology In Exercise Research For People With Multiple Sclerosis, U Dalgas, M Riemenschneider, Sm Gold, A Kalron, H Beckerman, Groot V De, R Dennett, T Edwards, La Pilutti, J Freeman Oct 2023

The Moxfo Initiative – Study Design: Considerations Related To Study Design And Methodology In Exercise Research For People With Multiple Sclerosis, U Dalgas, M Riemenschneider, Sm Gold, A Kalron, H Beckerman, Groot V De, R Dennett, T Edwards, La Pilutti, J Freeman

School of Health Professions

Background: Exercise as a subset of physical activity is a cornerstone in the management of multiple sclerosis (MS) based on its pleiotropic effects, but continued progression of the field requires better future designs and methodologies. Objectives: This paper outlines the work of the ‘Study design and methodology’ group of the MoXFo (moving exercise research forward) initiative, and addresses critical aspects and future directions when defining the research question of interest, and subsequently, designing the study and exercise intervention in MS patients. Methods: The work is based on the formation of an international expert panel formed within the MoXFo initiative. We …


Semi-Structured Interview Transcripts Of Fishing Gear Recyclers, Amanda Burton Oct 2023

Semi-Structured Interview Transcripts Of Fishing Gear Recyclers, Amanda Burton

Faculty of Science and Engineering Datasets

The study was conducted by Amanda Burton for a thesis entitled 'Towards a Circular Economy for Fishing Gear', submitted in partial fulfilment of the requirements for the degree of MSc Advanced Engineering Design, University of Plymouth, Faculty of Science and Engineering, Sept 2021. The study was in collaboration with the Interreg INdIGO project 2019-2023. Dataset Description: Transcripts of four interviews conducted with individuals engaged in recycling of End of Life and recovered Abandoned, Lost and Discarded fishing gear. Citation: Burton, A. (2023). Semi-structured interview transcripts of fishing gear recyclers. PEARL Research Repository. https://doi.org/10.24382/k17a-mh85.


Water Beetles (Coleoptera) Associated With Afrotemperate Forest Patches In The Garden Route National Park, South Africa, Matthew S. Bird, David T. Bilton, Musa C. Mlambo, Renzo Perissinotto Oct 2023

Water Beetles (Coleoptera) Associated With Afrotemperate Forest Patches In The Garden Route National Park, South Africa, Matthew S. Bird, David T. Bilton, Musa C. Mlambo, Renzo Perissinotto

School of Biological and Marine Sciences

Southern Afrotemperate Forest is concentrated in the southern Cape region of South Africa and whilst it is relatively well known botanically, the fauna, specifically the aquatic invertebrate fauna, is poorly documented. The majority of remaining intact forest habitat is contained within the Garden Route National Park (GRNP), which straddles the provincial boundary between the Western and Eastern Cape. This study undertakes a survey of the water beetle fauna inhabiting the GRNP. The aquatic ecosystems within temperate forests of the region are poorly researched from an ecological and biodiversity perspective, despite being known to harbour endemic invertebrate elements. We collected water …


Outbreak Investigation Of Ndm-Producing Burkholderia Cepacia Causing Neonatal Sepsis In Pakistan, A Batool, A Yakoob, Zahid Anwar, Lovleen Tina Joshi, Durreshahwar Lone, Qasim Ahmed, Muhammad Usman Qamar, Ramsha Batool, Zikria Saleem, Yousef Bin Jardan, Mohammed Bourhia Oct 2023

Outbreak Investigation Of Ndm-Producing Burkholderia Cepacia Causing Neonatal Sepsis In Pakistan, A Batool, A Yakoob, Zahid Anwar, Lovleen Tina Joshi, Durreshahwar Lone, Qasim Ahmed, Muhammad Usman Qamar, Ramsha Batool, Zikria Saleem, Yousef Bin Jardan, Mohammed Bourhia

Peninsula Dental School

Aim: To investigate the outbreak of Burkholderia cepacia complex (BCC), mortality, antimicrobial resistance and associated risk factors in the neonatal intensive care unit. Method: Eighteen blood culture samples from neonates and twenty swab samples from different neonatal intensive care unit surfaces were collected. The VITEK 2 was used to confirm the isolates and generate the antibiogram. PCR was used to identify blaNDM. Results: Eighteen samples tested positive for BCC, and 10/18 (55.5%) of the neonates died. 13/18 (72%) of the neonates had late-onset neonatal sepsis, and 10/18 (55%) had low birth weight. Resistance to minocycline and chloramphenicol was 100%, 72.2% …