Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Plymouth

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 361 - 390 of 11813

Full-Text Articles in Entire DC Network

Only One Percent Of Important Shark And Ray Areas In The Western Indian Ocean Are Fully Protected From Fishing Pressure, Jesse E. M. Cochran, Ryan Charles, Andrew J. Temple, Peter M. Kyne, Emiliano García‐Rodríguez, Adriana Gonzalez‐Pestana, Amanda Batlle‐Morera, Théophile L. Mouton, Asia O. Armstrong, Christoph A. Rohner, Darren J. Coker, Royale S. Hardenstine, Alexander Kattan, Ashlie J. Mcivor, Viktor Nunes Peinemann, Kaitlyn A. O'Toole, Lea Palm, Eloise B. Richardson, Kalli Valappil Akhilesh, Haleh Ali Abedi, Reem K. Almealla, Dareen Almojil, Samantha Andrzejaczek, Arzucan N. Askin, Avik A. Banerjee, Hamid R. Bargahi, Alissa J. Barnes, Svetlana Barteneva‐Vitry, Siamak Behzadi, Aymeric Bein Jan 2026

Only One Percent Of Important Shark And Ray Areas In The Western Indian Ocean Are Fully Protected From Fishing Pressure, Jesse E. M. Cochran, Ryan Charles, Andrew J. Temple, Peter M. Kyne, Emiliano García‐Rodríguez, Adriana Gonzalez‐Pestana, Amanda Batlle‐Morera, Théophile L. Mouton, Asia O. Armstrong, Christoph A. Rohner, Darren J. Coker, Royale S. Hardenstine, Alexander Kattan, Ashlie J. Mcivor, Viktor Nunes Peinemann, Kaitlyn A. O'Toole, Lea Palm, Eloise B. Richardson, Kalli Valappil Akhilesh, Haleh Ali Abedi, Reem K. Almealla, Dareen Almojil, Samantha Andrzejaczek, Arzucan N. Askin, Avik A. Banerjee, Hamid R. Bargahi, Alissa J. Barnes, Svetlana Barteneva‐Vitry, Siamak Behzadi, Aymeric Bein

School of Biological and Marine Sciences

The Western Indian Ocean (WIO) is known for its high diversity of chondrichthyans (sharks, rays, and chimaeras). However, intense fishing pressure has led to severe population declines and local extinctions of several species. The Important Shark and Ray Area (ISRA) process is a collaborative, evidence-based approach used to identify critical habitat for chondrichthyans. We analysed ISRAs across the WIO to quantify the diversity of research methods used to identify them, evaluate spatial overlap with designated marine protected areas (MPAs), model the influence of several species- and jurisdiction-specific variables on ISRA delineation, and explore the importance of incorporating unpublished data into …

Go to article

Unravelling Impact Of Comorbidities On Mortality Risks In Ckd Patients During The Covid-19 Pandemic: An Explainable Ai-Driven Study, Zeinab Abdollahi, Lin Huo, Donald Fraser, Shang-Ming Zhou Jan 2026

Unravelling Impact Of Comorbidities On Mortality Risks In Ckd Patients During The Covid-19 Pandemic: An Explainable Ai-Driven Study, Zeinab Abdollahi, Lin Huo, Donald Fraser, Shang-Ming Zhou

School of Nursing and Midwifery

ObjectivesThe chronic kidney disease (CKD) patients were at high risk for severe clinical complications during the COVID-19 pandemic. Our objectives were to evaluate comorbidity prevalence; predict mortality risks for CKD patients during the pandemic; assess how various health factors interact to influence mortality; and provide insights for targeted prevention strategies.MethodWe analysed data from 186,396 CKD patients in Mexico during the entire pandemic (Jan 2020- May 2023). Explainable artificial intelligence (XAI) methods with extreme gradient boosting (XGBoost) models and Shapley Additive Explanations (SHAP) were developed to predict mortality for CKD patients with model interpretations. Different metrics were used to comprehensively evaluate …

Go to article

Landworks Evaluation 1 April 2024 To 31 March 2025: Generating A Harm Reduction And Desistance Community, Patricia Gray, Julie Parsons Jan 2026

Landworks Evaluation 1 April 2024 To 31 March 2025: Generating A Harm Reduction And Desistance Community, Patricia Gray, Julie Parsons

School of Law, Humanities and Social Sciences

This year, LandWorks has experienced both highs and profound challenges. In July 2024, LandWorks won the Overall Award for Excellence at the Charity Awards — the most prestigious awards scheme in the charity sector. The judges highlighted LandWorks’ greatest achievement as “the way it built trust with its trainees and helped them rebuild their lives by understanding the experiences that led to their criminal behaviour in the first place.” Staff, trainees, and graduates were deeply proud of this recognition, which serves as a national endorsement of LandWorks’ accomplishments since its establishment in 2013. Alongside this success, the past twelve months …

Go to article

Mobile Apps For Psychotic Disorders: A Systematic Review Protocol, Ananya Ananthakrishnan, Aditya Narain Sharma, David Anderson, Rohit Shankar, Edward Meinert Jan 2026

Mobile Apps For Psychotic Disorders: A Systematic Review Protocol, Ananya Ananthakrishnan, Aditya Narain Sharma, David Anderson, Rohit Shankar, Edward Meinert

Peninsula Medical School

BackgroundEarly intervention for psychotic spectrum disorders can improve long-term outcomes, but service availability and quality can vary globally. Mobile apps have the potential to provide personalised and accessible support for people with psychotic disorders via features such as symptom monitoring, medication reminders, and self-management interventions. Existing reviews have provided an overview of such apps and their feasibility but lack a synthesis of their efficacy, safety, and acceptability. Addressing this gap would guide future app designs and facilitate their implementation by informing clinical and policy decisions. The purpose of this systematic review will be to synthesise the evidence about existing mobile …

Go to article

Lung Epithelial And Alveolar Macrophage-Like Cell Interactions Significantly Modify Innate Responses To Bacterial Endotoxin With The Involvement Of Direct Cellular Contacts, Tnf-Α, Icam1 And Mcp-1, Connor Wood, Shagun Khera, Minjeong Woo, Vikram Sharma, Justyna Lopatecka, Frederic Coulon, Zaheer Nasir, Vincent Delorme, Simon K. Jackson, György Fejer Jan 2026

Lung Epithelial And Alveolar Macrophage-Like Cell Interactions Significantly Modify Innate Responses To Bacterial Endotoxin With The Involvement Of Direct Cellular Contacts, Tnf-Α, Icam1 And Mcp-1, Connor Wood, Shagun Khera, Minjeong Woo, Vikram Sharma, Justyna Lopatecka, Frederic Coulon, Zaheer Nasir, Vincent Delorme, Simon K. Jackson, György Fejer

School of Biomedical Sciences

Introduction: Lung alveolar macrophages (AMs) and epithelial cells form the first line of defense against inhaled pathogens. Their interactions strongly influence innate immune responses in the lung, yet the mechanisms underlying this cross-talk remain incompletely understood. Methods: In this study, we established a co-culture system using a primary model of AMs (MPI alveolar macrophage-like cells) and MLE-12 alveolar epithelial cells to investigate innate responses and cellular interactions during bacterial lipopolysaccharide (LPS)-induced TLR4 activation. Results: Cytokine and chemokine profiling revealed that co-cultures exhibited significantly enhanced proinflammatory responses to both LPS and TLR2 ligands—including IL-6, TNF-a, and MCP-1 secretion—compared with mono-cultures. Strikingly, …

Go to article

Collaborating With ‘Blue Food’ System Stakeholders To Achieve Optimal Nutritional Health And Wellbeing In Less Affluent Communities, Clare Pettinger, Louise Hunt, Carol Wagstaff Jan 2026

Collaborating With ‘Blue Food’ System Stakeholders To Achieve Optimal Nutritional Health And Wellbeing In Less Affluent Communities, Clare Pettinger, Louise Hunt, Carol Wagstaff

School of Health Professions

UK food system transformation is urgently needed, but to date, minimal research has investigated ‘blue foods’ probably because they are ethically nuanced. There exists a paradox whereby materially deprived communities should be eating more fish to meet nutritional requirements, yet there is a global ‘red flag’ around global overfishing. New collaborative and creative solutions are, therefore, needed to tackle such food system inequities. By working together, all voices can be equally heard when decisions are being made to improve the system. Similarly, innovation and disruption of established supply chains will enable better access to healthy, affordable and tasty food that …

Go to article

Understanding Recruitment To A Randomised Controlled Trial (Rct) During Liver Transplantation: An Observational Mixed-Methods Study Within A Trial (Swat), Katherine Elizabeth Sarah Coppack, Ilya Kantsedikas, Edgar Brodkin, Ee Neng Loh, Gareth Ambler, Suneetha Ramani Moonesinghe, Jeremy Fabes, Vivienne Hannon, Michael Spiro, Duncan Wagstaff Jan 2026

Understanding Recruitment To A Randomised Controlled Trial (Rct) During Liver Transplantation: An Observational Mixed-Methods Study Within A Trial (Swat), Katherine Elizabeth Sarah Coppack, Ilya Kantsedikas, Edgar Brodkin, Ee Neng Loh, Gareth Ambler, Suneetha Ramani Moonesinghe, Jeremy Fabes, Vivienne Hannon, Michael Spiro, Duncan Wagstaff

Peninsula Medical School

Objectives Perioperative randomised controlled trials (RCTs) in liver transplantation are relatively infrequent. RCTs performed in this complex patient population need to be robustly conducted to maximise patient benefit and graft utility given the scarcity of donor organs. Recruitment challenges can compromise RCTs and studies in this population face unique challenges due to recipient illness severity, their comorbidities, demographics and the geographical constraints of specialist transplant centres. Emergency presentation and after-hours admission may further limit patients’ capacity or readiness to consider trial participation. This Study Within a Trial (SWAT) specifically explored motivators and barriers to recruitment in patients awaiting liver transplantation.Design …

Go to article

Single‐Use Versus Multiple‐Use Endotracheal Suction Catheters In Mechanically Ventilated Patients: A Feasibility Randomised Controlled Trial, Mohamed H. Eid, Kevin Hambridge, Patricia Schofield, Jos M. Latour Jan 2026

Single‐Use Versus Multiple‐Use Endotracheal Suction Catheters In Mechanically Ventilated Patients: A Feasibility Randomised Controlled Trial, Mohamed H. Eid, Kevin Hambridge, Patricia Schofield, Jos M. Latour

School of Nursing and Midwifery

BackgroundIn resource-limited settings, single-use open endotracheal suction catheters are commonly used multiple times. The current evidence of this practice on ventilator-associated pneumonia (VAP) among mechanically ventilated patients remains unclear.AimThe aim of this study was to test the feasibility of single-use and multiple-use endotracheal suction catheters flushed with chlorhexidine versus standard care (multiple-use endotracheal suction catheters flushed with normal saline) to reduce VAP in resource-limited intensive care units (ICUs) and evaluate study methods for designing a future definitive randomised controlled trial (RCT).Study DesignA three-armed feasibility RCT was conducted in three ICUs at a university hospital in Egypt.ResultsSixty mechanically ventilated patients were …

Go to article

Exploring And Critiquing Corporate Law Practice In Nigeria: Legal Essays In Corporate Governance, Directorship, Taxation, Business Vehicles, And Other Business Combinations, Goodtime Okara Jan 2026

Exploring And Critiquing Corporate Law Practice In Nigeria: Legal Essays In Corporate Governance, Directorship, Taxation, Business Vehicles, And Other Business Combinations, Goodtime Okara

School of Law, Humanities and Social Sciences Theses

This integrative work comprised seven doctrinal peer-reviewed publications produced between 2020 and 2022. The publications aimed to enhance understanding of the dynamics and regulatory complexities in corporate governance (CG), directorship, taxation, business vehicles, and other business combinations in Nigeria. The publications explored six important facets of corporate law practice in Nigeria, namely (i) the challenges and prospects of the Limited Liability Partnership (LLP) and the Limited Partnership (LP) in Nigeria (ii) the potential impact of CG in Nigeria (iii) the efficacy of one-person companies in Nigeria (iv) the legal impact of the Finance Act 2019 on taxation, mergers, and other …

Go to article

The Impact Of Trade Liberalisation On Human Rights To Freshwater For Domestic Uses In The Developing World: An Examination Of Nigeria., Dickson Esonarae Jan 2026

The Impact Of Trade Liberalisation On Human Rights To Freshwater For Domestic Uses In The Developing World: An Examination Of Nigeria., Dickson Esonarae

School of Law, Humanities and Social Sciences Theses

AbstractName: Dickson Efosa Esonarae.Title: The Impact of Trade Liberalisation on Human Rights to Freshwater for domestic uses in the Developing World: An Examination of Nigeria.Freshwater is a vital life-sustaining resource. Though considered basic in developed countries, it is often scarce and mostly of inadequate quality in the developing world (Global South), with the WHO and UNICEF Report estimating about 1.1 billion people globally lacking access. Consequently, several countries are determined to provide freshwater for their people but often hampered by financial constraints for the requisite infrastructure. Considering this limitation, the International Economic Institutions (IEIs) identified the private sector as the …

Go to article

Evaluating Blanket Mire Vegetation Recovery Following Hydrological Restoration, With Specific Focus On The Influence Of Molinia Caerulea, Oscar Kemble Jan 2026

Evaluating Blanket Mire Vegetation Recovery Following Hydrological Restoration, With Specific Focus On The Influence Of Molinia Caerulea, Oscar Kemble

School of Geography, Earth and Environmental Sciences Theses

This thesis evaluates the ecological processes involved in passive blanket peatland vegetation restoration following hydrological rewetting and evaluates the role of Molinia caerulea tussock development as a barrier to blanket mire vegetation establishment. Using data collected from restoration pools and terrestrial peat surfaces across blanket bog habitats on Dartmoor National Park, vegetation responses to rewetting over timescales of up to 10 years were evaluated. Observations were made on the restorative processes of terrestrialisation in pools and paludification of the terrestrial peat surface, and on the role of M. caerulea tussocks in shaping microclimates and vegetation assemblages. Results show that aquatic …

Go to article

A Conceptual Framework For Improving The Oral Health Of Children With Disabilities, Shiamaa Al-Mashhadani Jan 2026

A Conceptual Framework For Improving The Oral Health Of Children With Disabilities, Shiamaa Al-Mashhadani

Peninsula Dental School Theses

AbstractTitle: A Conceptual Framework for Improving the Oral Health of Children with DisabilitiesShiamaa Shihab Al-MashhadaniIntroduction:The effect of good oral health contributes to improving general health, well-being, and quality of life. Children with disabilities are more likely to develop oral diseases than the general population. They are disproportionately affected by dental diseases such as high dental caries, periodontal disease prevalence, missing teeth, and malocclusion. There are many challenges that children with disabilities and their carers experience regarding oral health, including access to dental care, availability of preventive interventions, oral health literacy, and education.This study aims to understand the personal experiences and …

Go to article

Variability In Practice And Outcomes Of Laparoscopic Cholecystectomy And Bile Duct Exploration (Lcbde) For Treatment Of Bds – A Survey And Multi-Centre Audits Of Practice In The Uk, Andrei Jackson Jan 2026

Variability In Practice And Outcomes Of Laparoscopic Cholecystectomy And Bile Duct Exploration (Lcbde) For Treatment Of Bds – A Survey And Multi-Centre Audits Of Practice In The Uk, Andrei Jackson

Peninsula Medical School Theses

AbstractTitle: Variability in Practice and Outcomes of Laparoscopic Cholecystectomy and Bile Duct Exploration (LCBDE) for Treatment of Bile Duct Stones– a Survey and Multi-Centre Audits of Practice in the UKIntroduction: The practice of managing suspected/confirmed bile duct stones (BDS) can vary significantly in the UK. The optimal management approach for suspected or confirmed BDS in patients with symptomatic gallstones remains unclear. We aimed to assess this variability in practice and outcomes of laparoscopic bile duct exploration in the UK.Methods: A UK-wide survey and two national multicentre audits were conducted. An electronic survey containing 40 questions on various aspects of management …

Go to article

Growth In The Margins: Field Measured Protein Metabolism Rates In The Common Limpet, Patella Vulgata, Ignacio A. Cienfuegos, Benjamin J. Ciotti, Richard A. Billington, Paul A. Sutton, Keiron P.P. Fraser Jan 2026

Growth In The Margins: Field Measured Protein Metabolism Rates In The Common Limpet, Patella Vulgata, Ignacio A. Cienfuegos, Benjamin J. Ciotti, Richard A. Billington, Paul A. Sutton, Keiron P.P. Fraser

School of Biological and Marine Sciences

Intertidal shores are characterised by a high variability in abiotic conditions, resulting in marked daily, tidal, seasonal and vertical differences in stress conditions, yet our ability to understand the consequences for key physiological processes at corresponding scales are limited. In particular, no previous studies have directly measured protein metabolism, the key process underpinning animal growth, in the field, in any organism. We measured whole-animal (SGR) and tissue (TSGR) mass growth, protein metabolism (synthesis (ks), degradation (kd) and growth (kg)), RNA to protein ratios and oxidative stress in Patella vulgata in the field every season …

Go to article

Gelatinous Zooplankton As Indicators In The Kunming Montreal Global Biodiversity Framework, John Terenzini, Laura J. Falkenberg, Sanae Chiba, Matthew Faith, Robert Puschendorf, Abigail Mcquatters-Gollop Jan 2026

Gelatinous Zooplankton As Indicators In The Kunming Montreal Global Biodiversity Framework, John Terenzini, Laura J. Falkenberg, Sanae Chiba, Matthew Faith, Robert Puschendorf, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

Global biodiversity frameworks require robust, representative indicators to effectively track progress towards conservation targets. Spatial and temporal gaps in global marine biodiversity datasets, however, and a limited number of marine biodiversity indicators, limit our ability to effectively manage marine ecosystems. Despite the ecological and socio-economic significance of marine ecosystems, they remain underrepresented in current indicator suites, particularly in the recently adopted Kunming-Montreal Global Biodiversity Framework (KMGBF). Gelatinous zooplankton (GZ), a key yet often overlooked component of marine ecosystems, have the potential to strengthen biodiversity assessments through their responsiveness to environmental change and impacts on several contributions of the ocean to …

Go to article

Children And Adults Across 15 Countries Believe In Human Uniqueness Of Mind: A Cross-Cultural Investigation Of Cross-Species Mind Perception, Karri Neldner, Luke Maurits, Magie Junker, Lara Abbas, Nayrouz Abbas, Arianna Abis, Federica Amici, Bernardo Arroyo-Garcia, Negar Asghari, Giovanna Barragán Pardo, Zhen Zhang, Junior Peña Chumacero, Ardain Dzabatou, Dustin Eirdosh, Susan Hanisch, Tom Herrnsdorf, Tom Hovehne, Alicia Junker, Patricia Kanngiesser, Felipe Villa Larens, Safaa Mahmoud, Sandra Masaquiza, Iino Masato, Risma Illa Maulany, Tongtong Meng, Kardelen Mutlu, Putu Oka Ngakan, Ebru Peközer, Ljubica Petrović, Mirella Christy Rehatalanit Jan 2026

Children And Adults Across 15 Countries Believe In Human Uniqueness Of Mind: A Cross-Cultural Investigation Of Cross-Species Mind Perception, Karri Neldner, Luke Maurits, Magie Junker, Lara Abbas, Nayrouz Abbas, Arianna Abis, Federica Amici, Bernardo Arroyo-Garcia, Negar Asghari, Giovanna Barragán Pardo, Zhen Zhang, Junior Peña Chumacero, Ardain Dzabatou, Dustin Eirdosh, Susan Hanisch, Tom Herrnsdorf, Tom Hovehne, Alicia Junker, Patricia Kanngiesser, Felipe Villa Larens, Safaa Mahmoud, Sandra Masaquiza, Iino Masato, Risma Illa Maulany, Tongtong Meng, Kardelen Mutlu, Putu Oka Ngakan, Ebru Peközer, Ljubica Petrović, Mirella Christy Rehatalanit

School of Psychology

The way humans relate to other animals is fundamentally shaped by whether we perceive ourselves as unique, with feelings and thoughts not shared by other animals. How beliefs about animals’ ability to feel and think develop across cultures remains largely unexplored. We asked children and adolescents (4–17 years, N = 1025) and adults (N = 190) from 33 urban and rural communities across 15 countries whether animals have thoughts or feelings (judgments of presence), and whether those thoughts or feelings are human-like (judgments of similarity). Bayesian analyses revealed that participants generally ascribed non-human animals the ability for thoughts and feelings. …

Go to article

Picturing The Past: The Role Of Photo Cue Visual Perspective On Positive Autobiographical Memory Recall In Dysphoria, Sarah Snow, Zachary Adolph Niese, Julie L Ji Jan 2026

Picturing The Past: The Role Of Photo Cue Visual Perspective On Positive Autobiographical Memory Recall In Dysphoria, Sarah Snow, Zachary Adolph Niese, Julie L Ji

School of Psychology

Positive autobiographical memory plays a key role in emotional well-being and is distorted by cognitive processing biases in dysphoria. This experiment investigated how the visual perspectives (first-person vs. third-person) of personal photographs influence recall of positive memories depending on dysphoria. Eighty-five participants (42 low dysphoria, 43 high dysphoria) submitted photos of positive events from both perspectives. Later, participants recalled these events while viewing either a first- or third-person photo before rating and describing their memory. While first-person photos promoted more recall from an own-eyes vantage point regardless of dysphoria level, dysphoria was still associated with greater observer-like recall, reduced mental …

Go to article

Video Interaction Guidance With Adults With Intellectual Disabilities And Their Support Workers: A Service Evaluation, Áine Maguire, Vicky Anagnostopoulou, Joe Levi-French, Deanna J. Gallichan Jan 2026

Video Interaction Guidance With Adults With Intellectual Disabilities And Their Support Workers: A Service Evaluation, Áine Maguire, Vicky Anagnostopoulou, Joe Levi-French, Deanna J. Gallichan

School of Psychology

Background: This service evaluation focused on support workers' perceptions of Video Interaction Guidance (VIG) offered by an NHS Community Learning Disabilities Team. Methods: A mixed-methods design was employed. Support workers developed goals and rated their progress before and after VIG sessions. Thematic analysis was used to analyse qualitative data on the nature of the goals developed, and the strengths and working points identified. The differences between progress ratings before and after VIG were analysed using the Wilcoxon signed-rank test. Retrospective interviews helped to further understand support workers' experiences of VIG. Findings: Support workers identified goals, strengths and working points that …

Go to article

Adherence And Compliance With Exercise Training In Progressive Multiple Sclerosis: Rates And Correlates From The Cogex Trial, Cogex Research Team, Robert W. Motl, Andrew Argie, Roberto S. Hernandez, Brian M. Sandroff, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Maria A. Rocca, Amber Salter, Anthony Feinstein Jan 2026

Adherence And Compliance With Exercise Training In Progressive Multiple Sclerosis: Rates And Correlates From The Cogex Trial, Cogex Research Team, Robert W. Motl, Andrew Argie, Roberto S. Hernandez, Brian M. Sandroff, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Maria A. Rocca, Amber Salter, Anthony Feinstein

School of Health Professions

Background: There is limited understanding of adherence and compliance rates for exercise training(ET) in people with progressive multiple sclerosis(PMS).Objectives: This secondary, exploratory data analysis examined rates of adherence and compliance for continuous, moderate intensity training and high-intensity intervaltraining(HIIT) and possible correlates among people with PMS from the CogEx trial.Methods: CogEx was a multi-site, multi-arm, randomized, double-blinded, and shamcontrolled trial undertaken by 11 sites in six di8erent countries. Participants(N=311) wererandomized into one of four conditions with di8erent combinations of ET and cognitive rehabilitation, including respective sham conditions, delivered twice weekly over 12 weeks.The analysis focused on adherence and compliance rates and …

Go to article

Rethinking Remimazolam: Reconciling Regulatory Positioning With Clinical Reality, Theodora Wingert, J Robert Sneyd Jan 2026

Rethinking Remimazolam: Reconciling Regulatory Positioning With Clinical Reality, Theodora Wingert, J Robert Sneyd

More Faculty of Health Research

Goyal and colleagues share a large United States health system’s experience of 9431 cases of real-world remimazolam use, offering insight into current practice patterns, recovery times, and accurate adverse event rates. The authors report rapid recovery after remimazolam, including shorter time to post-anaesthesia care unit discharge readiness and faster return to baseline on the Richmond Agitation–Sedation Scale following flumazenil administration, with a critical event rate of 0.7%. Interesting practice patterns were observed, including frequent co-administration with other anaesthetics rather than as a sole agent. Although only licensed for procedural sedation in the United States, the authors reported extensive use of …

Go to article

Mapping The Role Of Occupational Therapy Within Primary Care Services: A Scoping Review, Katie-Mai Davies, Alison Warren, Sam Wakley Jan 2026

Mapping The Role Of Occupational Therapy Within Primary Care Services: A Scoping Review, Katie-Mai Davies, Alison Warren, Sam Wakley

School of Health Professions

Introduction:Occupational therapy is named a key profession within primary care, with growing demand due to an ageing population and increase of people living with long-term conditions. Despite this, occupational therapy within primary care remains an evolving, under researched area of practice. This scoping review explored the role of occupational therapy within primary care including the populations and interventions currently provided.Methods:The Joanna Briggs Institute (JBI) methodology for scoping reviews was followed with systematic searches conducted across CINAHL, PubMED and AMED databases with grey literature also sourced. The findings are presented in tabular format and analysed using descriptive statistics and frequency counts …

Go to article

A Feasibility Randomised Controlled Trial Of An Exergaming Device Aimed At Improving Mobility In Children With Cerebral Palsy, Rachel Rapson, Bernie Carter, Harriet Hughes, Jos M. Latour, Wendy Ingram, Jonathan Marsden Jan 2026

A Feasibility Randomised Controlled Trial Of An Exergaming Device Aimed At Improving Mobility In Children With Cerebral Palsy, Rachel Rapson, Bernie Carter, Harriet Hughes, Jos M. Latour, Wendy Ingram, Jonathan Marsden

School of Health Professions

Aim: A novel interactive exergaming device enables children with cerebral palsy (CP) to exercise whilst standing. A small study showed gains in ankle motion after training with the device. This study explores the feasibility of a community-based randomised controlled trial (RCT) using this device to improve mobility in children with CP (Registered ISRCTN80878394). Method: Fifteen children with CP Gross Motor Function Classification System (GMFCS) levels I-III were randomised 1:1 to either 10-weeks training with the device or usual care. Two potential primary outcome measures were assessed at 10-weeks with 20-week follow up: motion of the centre-of-mass estimate while stepping (Next …

Go to article

Exploring The Acceptability Of Integrating Dietitians Into Primary Care Dental Services For Children, Lauren Hallewell, Raul Bescos, Zoe Brookes, Tracey Parkin, Robert Witton, Patricia Casas-Agustench Jan 2026

Exploring The Acceptability Of Integrating Dietitians Into Primary Care Dental Services For Children, Lauren Hallewell, Raul Bescos, Zoe Brookes, Tracey Parkin, Robert Witton, Patricia Casas-Agustench

School of Health Professions

BACKGROUND: Dental caries is a common childhood non-communicable disease strongly associated with high sugar intake. Beyond oral health, a poor diet can affect children's growth, development, and overall well-being. While dietary advice is central to preventive dental care, some primary care dental clinics have introduced body mass index (BMI) assessments and further dietary advice to address wider nutritional concerns in children. However, these efforts are often constrained by limited nutrition training, time constraints and concerns about sensitivity. Integrating dietitians into primary dental care may help overcome these barriers by enhancing dietary guidance, supporting broader nutritional needs and facilitating structured BMI …

Go to article

Defining Consensus‐Based Components For Integrating Dietitians Into Primary Dental Care For Paediatric Populations: A Delphi Study, Lauren Hallewell, Raul Bescos, Zoe Brookes, Robert Witton, Patricia Casas‐Agustench Jan 2026

Defining Consensus‐Based Components For Integrating Dietitians Into Primary Dental Care For Paediatric Populations: A Delphi Study, Lauren Hallewell, Raul Bescos, Zoe Brookes, Robert Witton, Patricia Casas‐Agustench

School of Health Professions

Background: Diet is a modifiable risk factor linking oral and systemic health, contributing to dental caries and weight-related outcomes (including underweight, overweight and obesity) in the paediatric population. However, dietary advice provided by dental professionals in primary dental care is often brief and sugar-focused, representing a missed opportunity to address shared risk factors. Integrating dietitians into primary dental care may support more holistic paediatric preventative care. Objective: To develop expert consensus on the components required to integrate dietitians into primary dental care to address diet as a common risk factor in paediatric oral health and weight-related outcomes. Methods: A three-round …

Go to article

Quantifying The Response Of Bankfull Channel Width To Active Faulting In The Qianhe Graben On The Southwest Margin Of Ordos Block, China, Zhiheng Liu, Sarah Boulton, Suiping Zhou, Jianhua Guo, Tingting Wu, Wenjie Zhang, Ling Han Jan 2026

Quantifying The Response Of Bankfull Channel Width To Active Faulting In The Qianhe Graben On The Southwest Margin Of Ordos Block, China, Zhiheng Liu, Sarah Boulton, Suiping Zhou, Jianhua Guo, Tingting Wu, Wenjie Zhang, Ling Han

School of Geography, Earth and Environmental Sciences

River longitudinal profiles have been widely used to quantify the transient landscape response to active faulting, but the fluvial cross-section is often ignored, yet width can also reveal river incision and tectonic activity. Channel width responds to tectonic forcing through flow concentration effects resulting in channel narrowing where vertical incision dominates during uplift acceleration. Here we employ a novel bankfull channel width extraction method using Landsat and ZY-3 satellite images, and SRTM DEM data to evaluate the cross-section landscape response to active faulting in the Qianhe Graben of southwest Ordos, China. Although some areas are difficult to access (e.g., thick …

Go to article

Presence And Characteristics Of Plastics And Microplastics On The Seabed Of The Western English Channel, Faye Read, Andrew Turner Jan 2026

Presence And Characteristics Of Plastics And Microplastics On The Seabed Of The Western English Channel, Faye Read, Andrew Turner

School of Geography, Earth and Environmental Sciences

Little is known about the presence, distribution, origins and characteristics of plastic litter and microplastics on the ocean floor. In this study, plastics trawled from the bed of the western English Channel have been categorised and analysed by a variety of optical and spectroscopic techniques. A total of 90 plastic samples were classified, in descending order of abundance, as food-drink packaging, unknown, homeware, military and fishing. Most samples showed varying degrees of weathering (e.g., discolouration, distortion, cracking, fragmentation) and were visibly fouled by calcareous deposits. The majority of samples were constructed of polymers of negative buoyancy (e.g., polyamides, polyethylene terephthalate …

Go to article

Investigating The Impact Of Carboxylated Polystyrene Nanoplastics In The Liver Using Cell Lines And Precision-Cut Liver Slices, Namrata Pandey, Paula Boeira, Nathaniel J. Clark, Eleanor T. Walker, Somaiah Aroori, Jemimah Denson, Richard C. Thompson, Matthew E. Cramp, Shilpa Chokshi, Ashwin Dhanda Jan 2026

Investigating The Impact Of Carboxylated Polystyrene Nanoplastics In The Liver Using Cell Lines And Precision-Cut Liver Slices, Namrata Pandey, Paula Boeira, Nathaniel J. Clark, Eleanor T. Walker, Somaiah Aroori, Jemimah Denson, Richard C. Thompson, Matthew E. Cramp, Shilpa Chokshi, Ashwin Dhanda

Peninsula Medical School

Background and Aims: Increasing reports of plastic accumulation in human tissue have raised concerns about potential adverse health outcomes. Evidence of negative effects of nanoplastics is heterogeneous and provides limited insights into the underlying pathogenic toxicity mechanisms in humans. Methods: In the present study, carboxylate-modified fluorescently labelled polystyrene nanoparticles (PS NPs) were used to investigate uptake and cytotoxicity in three different hepatic models of varying complexity, including HepG2 cells, IHH cells, and human precision-cut liver slices (hPCLS). Results: The results show model- and dose-dependent effects on hepatocytes. 74.2% ± 13.4% of the IHH cells showed PS NPs uptake at 0.1 …

Go to article

Psychotropic Medication Prescribing To Children And Young People Mental Health Inpatient Services: An English National Study, David Branford, Anne Webster, Marinos Kyriakopoulos, Shermin Imran, Prathiba Chitsabesan, Tina Irani, Teresa Randon, Kirsten Peebles, Rohit Shankar Jan 2026

Psychotropic Medication Prescribing To Children And Young People Mental Health Inpatient Services: An English National Study, David Branford, Anne Webster, Marinos Kyriakopoulos, Shermin Imran, Prathiba Chitsabesan, Tina Irani, Teresa Randon, Kirsten Peebles, Rohit Shankar

Peninsula Medical School

Background:Mental disorders frequently begin in childhood or adolescence. Worldwide, psychotropics are commonly prescribed for under-18s to stabilise behaviour, mood or thoughts. Psychotropics could cause long-term effects on children and young people (CYP) health, growth and development. There is a knowledge gap about psychotropic prescribing in CYP mental health inpatient units.Aims:To understand and compare psychotropic prescribing patterns in England mental health inpatient units for CYPs and to solicit CYP and their parents’ and carers’ views of it.Method:A national Quality Improvement programme authorised by National Health Service (NHS) England invited all English CYP mental health inpatient units to participate. The programme included …

Go to article

Small-Molecule Therapies Targeting Tumor-Associated Macrophages In Glioma: Mechanisms And Potential, Hua Wang, Heng Luo, Haijian Zhong, Amy Ockleton, Feng Jiang, Renhui Yi, Shaochun Yang, Ming Li Jan 2026

Small-Molecule Therapies Targeting Tumor-Associated Macrophages In Glioma: Mechanisms And Potential, Hua Wang, Heng Luo, Haijian Zhong, Amy Ockleton, Feng Jiang, Renhui Yi, Shaochun Yang, Ming Li

Peninsula Medical School

Glioblastoma, a highly prevalent and aggressive primary brain tumor, is marked by poor prognosis due to the blood-brain barrier and chemoresistance, which limit conventional pharmacotherapy. Recent research has pivoted toward targeting the tumor microenvironment, where tumor-associated macrophages (TAMs) drive gliomagenesis and malignant progression through immunosuppressive signaling. Small-molecule agents targeting TAMs have emerged as promising therapeutics, capable of reprogramming macrophage polarization, modulating immune cell dynamics, and suppressing glioma growth. This review explores the mechanistic roles of TAMs in glioma and evaluates how small-molecule compounds exert antitumor effects via TAM modulation. These insights lay a foundation for developing next-generation TAM-targeted therapies, offering …

Go to article

The Utility Of Fret/Flim-Based Bioassays For Monitoring Nrf2 Activation In Single Live Cells, Dina Dikovskaya, Albena T Dinkova-Kostova Jan 2026

The Utility Of Fret/Flim-Based Bioassays For Monitoring Nrf2 Activation In Single Live Cells, Dina Dikovskaya, Albena T Dinkova-Kostova

Peninsula Medical School

The Kelch-like ECH-associated protein 1 - Nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) partnership is vital for protection against oxidative stress, and its dysregulation has been linked to the pathogenesis of numerous chronic diseases. Under homeostatic conditions, Keap1 targets Nrf2 for ubiquitination and proteasomal degradation. When Keap1 is inactivated by electrophiles or Keap1-Nrf2 protein-protein interaction (PPI) inhibitors (termed inducers), Nrf2 accumulates and, in association with a small musculoaponeurotic fibrosarcoma (sMaf) protein, induces the transcription of networks of genes encoding cytoprotective proteins. To understand the PPIs between Nrf2 and Keap1 and the effect of inducers in the cellular context, we expressed …

Go to article

First Prev Next Last