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A Socio-Economic And Ecological Approach To Informing Sustainable Marine Management In Jersey, Channel Islands, Samantha Robyn Blampied
A Socio-Economic And Ecological Approach To Informing Sustainable Marine Management In Jersey, Channel Islands, Samantha Robyn Blampied
School of Biological and Marine Sciences Theses
Marine ecosystems support human life in multi-faceted ways and are depended on for food and income by many coastal communities. However, marine habitats are being altered by anthropogenic pressures, influencing the diversity and distribution of species, including species that are relied upon by commercial fisheries. Destructive fishing practices such as dredging and trawling can have adverse impacts on the seabed and associated species through the degradation and fragmentation of benthic habitats. Spatial management of marine areas is required to mitigate impacts, with Marine Protected Areas (MPAs) being advocated as tools that can not only protect and restore biodiversity but also …
Investigation Into A Brain-Computer Interface System For Music With Speech Imagery, Alberto Tates Puetate
Investigation Into A Brain-Computer Interface System For Music With Speech Imagery, Alberto Tates Puetate
School of Law, Humanities and Social Sciences Theses
Brain-computer interfaces (BCIs) aim to find a communication path with computers that dispenses with motor interaction using merely brain activity. This project investigates how BCI can have music as its destination, the system would allow people with motor impairments to get close to creative activities and offer musicians a novel dimension of performance. BCI systems present multiple challenges when attempting approaches in real-world circumstances. These challenges are encompassed in the transfer information rate and the deployability of such systems. BCI research is mainly medically focused therefore the brain activity measurement devices are designed under lab conditions, making them not portable …
Citizen Science In Marine Litter Research: A Review, L. A. Kawabe, N. P. Ghilardi-Lopes, A. Turra, K. J. Wyles
Citizen Science In Marine Litter Research: A Review, L. A. Kawabe, N. P. Ghilardi-Lopes, A. Turra, K. J. Wyles
School of Psychology
No abstract provided.
Graphene Based Electrochemical Biosensors For The Detection Of Blood Biomarkers Of Alzheimer’S Disease, Jagriti Sethi
Graphene Based Electrochemical Biosensors For The Detection Of Blood Biomarkers Of Alzheimer’S Disease, Jagriti Sethi
School of Engineering, Computing and Mathematics Theses
Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions of people around the world with no available treatments to cure, reverse or even slow down the disease progression. Detection of AD in the early stages, before the massive neuronal loss, is key to developing disease-modifying treatments and preventive strategies. The current AD diagnosis is largely based on evaluation tests such as Mini-Mental State Examination (MMSE), imaging techniques such as Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and postmortem autopsies. It is expensive and only available at the later/severe stages when the brain of the patient is already damaged …
Use Of Complex Environmental Data For Realistic Wave Tank Testing Of Wave Energy Converters, Daming Wang
Use Of Complex Environmental Data For Realistic Wave Tank Testing Of Wave Energy Converters, Daming Wang
School of Engineering, Computing and Mathematics Theses
Wave tank model testing is a commonly used method to assess the performance of Wave Energy Converters (WECs). Wave data collected for testing can be obtained by different instruments (e.g. buoys, ADCP, and HF radar). Currently, the widely accepted way to re-create the wave conditions for WEC model testing is to obtain wave parameters from the wave data collected and apply them to a suitable generic wave spectrum, such as the JONSWAP spectrum or Pierson-Moskowitz spectrum, then reproduce it in the wave tank. By using this method, each wave condition is simplified to several wave parameters such as the significant …
Molecular Control Of The Migratory Phase During Cutaneous Wound Healing, Chloe Elizabeth Bolton
Molecular Control Of The Migratory Phase During Cutaneous Wound Healing, Chloe Elizabeth Bolton
Other Faculty of Health Theses
Superficial cutaneous injuries occur on a huge scale across the globe; while most will resolve without intervention or any lasting damage, many will experience complications that arise through delayed healing or as a consequence of the skins protective barrier being breached. The migration of cutaneous cells across a wound site is a crucial factor in establishing permanent restoration of the skins integrity. This study provides insight into molecular events that facilitate the migratory ability of cutaneous cells during this phase of the healing process. Through subcellular analysis, molecular manipulation and various imaging techniques of in vivo and in vitro wound …
Novel Approaches To Assess Cellular Interactions And Their Role In The Pathology And Treatment Of Lymphoproliferative Disorders, Frances Hilary Rose Frend
Novel Approaches To Assess Cellular Interactions And Their Role In The Pathology And Treatment Of Lymphoproliferative Disorders, Frances Hilary Rose Frend
Other Faculty of Health Theses
Background: Migration and homing are essential to B-lymphocyte mediated immunity, and are driven by rapid, directed, and appropriate reorganisation of the actin cytoskeleton. Important observations have linked the cytoskeletal-rearrangements made by leukaemic B-lymphocytes of chronic lymphocytic leukaemia (CLL) to disease pathology. In particular, cytoskeletal alterations mediated by B-cell receptor (BCR) engagement or chemokine-binding are recognised to be central to the migration of CLL cells to lymphoid tissues, where they engage in the complex cellular and molecular interactions that underlie their survival, proliferation, and drug resistance. Further emphasising this importance, has been the observation that highly effective small molecule inhibitors that …
Nitrite And Insulin Lower The Oxygen Cost Of Atp Synthesis In Skeletal Muscle Cells By Pleiotropic Stimulation Of Glycolysis, Rosie Donnell
Nitrite And Insulin Lower The Oxygen Cost Of Atp Synthesis In Skeletal Muscle Cells By Pleiotropic Stimulation Of Glycolysis, Rosie Donnell
Other Faculty of Health Theses
Dietary nitrate lowers the oxygen cost of submaximal exercise, but precise mechanistic insight into how this occurs is lacking. Research suggests that dietary nitrate may render oxidative ATP synthesis more efficient, but evidence is inconclusive at present. This thesis aimed to establish how nitrite (a reduced form of nitrate) affects the bioenergetics of cultured skeletal muscle cells. Comparison between the acute effects of nitrite and insulin, a hormonal regulator of muscle function that increases mitochondrial efficiency, was explored to assess possible mechanistic overlap. Calculation of real-time intracellular ATP synthesis rates from simultaneous oxygen consumption and medium acidification measurements revealed the …
Prediction Of Cardiometabolic Risk In Children, Olubukola Ajala
Prediction Of Cardiometabolic Risk In Children, Olubukola Ajala
Other Faculty of Health Theses
Background: Three decades of clinical research have demonstrated that the risks of atherosclerotic cardiovascular disease (ACVD: coronary disease and ischaemic stroke), and the closely related type 2 diabetes (T2D) are established and influenced by events during childhood. This is at least partly because childhood obesity usually leads to adult adiposity; so, the currently high prevalence of adult cardiometabolic disease, means that obesity needs to be identified as early as possible, ideally in childhood. Screening for obesity largely relies on anthropometric measurements like body mass index (BMI), however this has many limitations including its inability to distinguish lean from fat mass. …
Atrial Fibrillation In Middle-Eastern Arabs And South Asians: Studies From A 20-Year National Registry In Qatar, Amar Mohammad Amin Farhan Salam
Atrial Fibrillation In Middle-Eastern Arabs And South Asians: Studies From A 20-Year National Registry In Qatar, Amar Mohammad Amin Farhan Salam
Other Faculty of Health Theses
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice accounting for approximately one-third of hospitalizations for cardiac rhythm disturbances and is associated with increased risk for stroke, heart failure and death. The epidemiology and clinical features of AF have primarily been characterized in whites of European-descent. The world literature on the epidemiology of AF among different ethnicities is very limited with most of the published reports of AF in non-white ethnicities focusing mainly on black (African-American) patients. The current work represents structured and staged examination of AF in two ethnic groups where very limited literature is available …
'Mercy, Tenderness, And Compassion': A Study Into The Inclusion Of Acts Of Communal And Familial Support Within Seventeenth-Century Quaker Records Of Sufferings, Toni Wadman
School of Law, Humanities and Social Sciences Theses
This thesis explores the inclusion of encounters of communal and familial compassion and support within seventeenth century Quaker records of sufferings. Whilst previous academic works have used these accounts of communal support to highlight the social integration of Friends within their local communities, little focus has been placed upon the purpose or reasoning behind their presence within Quaker suffering records. This thesis, therefore, examines how Friends perceived and understood these encounters as well as the reasoning and motivation behind their inclusion in their accounts of sufferings. To help answer these questions, this project consults the Original Records of Sufferings, handwritten …
Painting, Playing, Personas: Inserting Change In An Established Painting Practice, Robyn Jean Thomas
Painting, Playing, Personas: Inserting Change In An Established Painting Practice, Robyn Jean Thomas
School of Law, Humanities and Social Sciences Theses
This doctoral research project explores the impact and changes alternative identities —personas— and a play-based method have on my established painting practice while disentangling it from the belief that a single identity authentically makes a painting art. Its methodology provides a path to answering how using personas with 'play' within a painting practice form strategies meeting this project's aims. Three personas were created and applied across the first two stages of the studio inquiry using my painting practice's methods, including reiteration. In the third stage, continuing to paint independent of the personas, their impact and that of the infinite play …
Rethinking Liveness: An Exploration Of Phenomenological Liveness, Documentation, And Audience, Samantha Sully
Rethinking Liveness: An Exploration Of Phenomenological Liveness, Documentation, And Audience, Samantha Sully
School of Law, Humanities and Social Sciences Theses
This paper explores experiential liveness discourse through the lens of phenomenology, semiotics, and auto-ethnographical research. This thesis examined previous experiential liveness studies and discourses and how these ideologies build a discourse centred around audience/performer relationships, communitas and virtual communities. It explores the interactions between experiential and ontological liveness through documentation, digital archiving and Descartesian dualism. Further, this thesis re-frames core ontological terms within the phenomenological liveness context. It examines event and ritual as experiences and explores my experiences of liveness with reference to previous experiential liveness studies. Finally, this paper examines the importance of experiential liveness as its own discourse …
Endogenous Retroviral Proteins As Potential Drug Targets For Merlin-Deficient Tumours, Bora Agit
Endogenous Retroviral Proteins As Potential Drug Targets For Merlin-Deficient Tumours, Bora Agit
Peninsula Medical School Theses
Merlin is a tumour suppressor, and its loss is the major cause of a hereditary disease Neurofibromatosis type 2 (NF2) characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. Current surgical treatments and radiotherapy for this group of tumours are not fully effective and there is an urgent need for new therapeutic options. Human endogenous retroviruses (HERVs) are retroviruses that have been incorporated into the human genome during evolution, now comprising 5% of it. The majority of HERVs are defective except for a few groups, including type K (HERV-K) which kept full-intact …
Investigating ‘Active Citizenship’: A Journey Toward The Political Heart Of Education In The Company Of Hannah Arendt., Kevin Richard Walker
Investigating ‘Active Citizenship’: A Journey Toward The Political Heart Of Education In The Company Of Hannah Arendt., Kevin Richard Walker
Plymouth Institute of Education Theses
The formation of ‘active citizens’ has become a desirable educational outcome in mainstream secondary and adult education in the UK. However, there is a wide range of interpretations regarding what being ‘active’ as a citizen actually involves and a lack of consensus on the role of education in this process. Drawing on Arendt’s conception of action as the basis of political activity where “to be free and to act are the same” (Arendt 1968a: 153), I propose an understanding of ‘active citizenship’ which involves the appearance of an individual citizen in relationship with the shared public world. It is argued …
Cooperative Schools: Learning To Be Cooperative In A Changing Educational Landscape, Tracey Anne Downes
Cooperative Schools: Learning To Be Cooperative In A Changing Educational Landscape, Tracey Anne Downes
Plymouth Institute of Education Theses
Through a case study approach, this research considers what it means to be a cooperative school in the 21st Century and how this ideological stance impacts on stakeholders’ experiences. The research sought the perceptions and experiences of 99 staff members, pupils, governors and wider community, to illuminate the act of learning to be cooperative and to explore the role of cooperative schools in the current fractured education landscape in England. Multiple qualitative methods, such as interviews and observations, were used to generate data and Engeström’s Second Generation Cultural-Historical Activity Theory (CHAT) was used to explore the interconnectivity of a cooperative …
The Developing Maternal-Infant Relationship: A Qualitative Longitudinal Study, Jane Peters
The Developing Maternal-Infant Relationship: A Qualitative Longitudinal Study, Jane Peters
School of Nursing and Midwifery Theses
Aim The study aimed to explore maternal perceptions and the use of knowledge relating to their infant’s mental health over time using qualitative longitudinal research. Background There has been a growing interest in infant mental health over recent years. Much of this interest is directed through the lens of infant determinism, through knowledge regarding neurological development resulting in biological determinism. Research and policy in this field are directed toward individual parenting behaviours, usually focused on the mother. Despite this, there is little attention given to maternal perspectives of infant mental health, indicating that a more innovative approach to methodology is …
Exploring Factors That Influence Women’S Self-Management Of Rectal Emptying Difficulty, Sharon Eustice
Exploring Factors That Influence Women’S Self-Management Of Rectal Emptying Difficulty, Sharon Eustice
School of Nursing and Midwifery Theses
Aim The aim of this study was to pragmatically investigate a vital element of bowel function, where emptying the rectum is difficult in women, usually because of obstructive defaecation, secondary to rectocele. Background Rectal emptying difficulty in women is a sign of obstructive defaecation, which affects about one out of every ten women and can increase with age. Rectal emptying difficulty has a mostly unknown influence on women, and it is frequently a hidden issue. Women's self-management alternatives are underappreciated, as is the impact of such interventions on their quality of life. Despite the magnitude of the problem and its …
Identifying Novel Therapeutic Targets For Seizures And Brain Cancers, Jared Ching
Identifying Novel Therapeutic Targets For Seizures And Brain Cancers, Jared Ching
Peninsula Medical School Theses
Epilepsy describes a range of conditions characterised by unprovoked recurring seizures that are due to multiple factors including the excitatory neurotransmitter glutamate. A subgroup of patients with epilepsy may not respond to systemic treatment and therefore would become candidates for surgical therapy. A less invasive approach is vagal nerve stimulation, which I demonstrated is safe and effective in 100 patients, in the first UK based large case series. Another group of patients that suffer from intractable epilepsy are those with tumour associated seizures (TAS). In particular, patients diagnosed with glioblastoma multiforme can initially present with unexplained seizures or develop seizures …
Bayesian Methods For The Design And Analysis Of Cluster Randomised Controlled Trials, Benjamin Gary Jones
Bayesian Methods For The Design And Analysis Of Cluster Randomised Controlled Trials, Benjamin Gary Jones
Other Faculty of Health Theses
Cluster Randomised Controlled Trials involve randomising groups of participants, rather than the individual participants themselves, whilst the outcomes are measured on the participants. Whilst there are a number of practical and methodological advantages to such a design, there are also statistical implications, both in terms of study design and sample size calculation, and in analysis. The methodology underpinning the cluster randomised design is now well-established in the statistical literature. However, the overwhelming majority of methodological developments to date have been within the frequentist paradigm, and as such, there is an opportunity to explore methodological developments in the context of Bayesian …
Contributions Of Source-Constrained Search And Late Monitoring To Recall Accuracy, James Randle
Contributions Of Source-Constrained Search And Late Monitoring To Recall Accuracy, James Randle
Other Faculty of Health Theses
This thesis aimed to investigate in detail the processes underlying the control of recall accuracy. It is believed that recall accuracy control comprises processes occurring at memory search and post-retrieval. There is a large body of research concerning post-retrieval monitoring processes; however, less is known about how memory search is constrained and what factors affect this process.Chapter 2 developed and tested a new paradigm for measuring the accuracy of constrained search and monitoring processes simultaneously. Participants were able to selectively retrieve one of two lists irrespective of which list was the target list, indicating successful constrained search. A key role …
Dementia Friendly Flying: Investigating The Accessibility Of Air Travel For People Living With Dementia, Kate Turner
Dementia Friendly Flying: Investigating The Accessibility Of Air Travel For People Living With Dementia, Kate Turner
Other Faculty of Health Theses
A diagnosis of dementia should not mean the end of a person’s ability to participate in meaningful activities. However, accessibility for people living with dementia requires improvement across a range of settings. Anecdotal evidence and critical incident reporting suggests that air travel is not meeting the needs of people with dementia, although evidence-based research into air travel and dementia is extremely limited. This research bridges the gap in the evidence-base on the accessibility of air travel for people living with dementia from within the United Kingdom by: 1) Exploring the experiences of air travel of 10 people living with dementia …
Evidence-Based Clinical Practice Guidelines On The Management Of Pain In Older People – A Summary Report, Patricia Schofield, Margaret Dunham, Denis Martin, Gary Bellamy, Sally Anne Francis, Dave Sookhoo, Antonio Bonacaro, Eshtar Hamid, Rebecca Chandler, Aza Abdulla, Mike Cumberbatch, Roger Knaggs
Evidence-Based Clinical Practice Guidelines On The Management Of Pain In Older People – A Summary Report, Patricia Schofield, Margaret Dunham, Denis Martin, Gary Bellamy, Sally Anne Francis, Dave Sookhoo, Antonio Bonacaro, Eshtar Hamid, Rebecca Chandler, Aza Abdulla, Mike Cumberbatch, Roger Knaggs
School of Nursing and Midwifery
Objective: The objective of this study is to develop an update of the evidence-based guidelines for the management of pain in older people. Design: Review of evidence since 2010 using a systematic and consensus approach is performed. Results: Recognition of the type of pain and routine assessment of pain should inform the use of specific environmental, behavioural and pharmacological interventions. Individualised care plans and analgesic protocols for specific clinical situations, patients and health care settings can be developed from these guidelines. Conclusion: Management of pain must be considered as an important component of the health care provided to all people, …
The Feasibility And Acceptability Of Digital Technology For Health And Wellbeing In Social Housing Residents In Cornwall: A Qualitative Scoping Study, Sa Buckingham, T Walker, K Morrissey
The Feasibility And Acceptability Of Digital Technology For Health And Wellbeing In Social Housing Residents In Cornwall: A Qualitative Scoping Study, Sa Buckingham, T Walker, K Morrissey
School of Nursing and Midwifery
Objective The aim of this study was to explore the feasibility and acceptability of digital technology for improving health and wellbeing in social housing residents living in a deprived area in Cornwall, England. Methods Qualitative scoping study with focus groups and telephone interviews (23 participants in total). Focus groups and interviews were audio-recorded, transcribed verbatim and analysed thematically. Results Levels of use and experience with digital technology were diverse in this group, ranging from ‘willing and unable’ to ‘expert’ on a self-perceived scale. Overall, participants had positive perceptions of technology and were keen to try new technologies. Five categories of …
Exploring The Effect Of Implementing Affordable Socially Assistive Pet Robots In Eight Care Homes Before And During The Covid-19 Pandemic: A Stratified Cluster Randomised Controlled Trial And Mixed-Method Study., Hannah Bradwell, Katie Edwards, Rhona Winnington, Serge Thill, Victoria Allgar, Ray Jones
Exploring The Effect Of Implementing Affordable Socially Assistive Pet Robots In Eight Care Homes Before And During The Covid-19 Pandemic: A Stratified Cluster Randomised Controlled Trial And Mixed-Method Study., Hannah Bradwell, Katie Edwards, Rhona Winnington, Serge Thill, Victoria Allgar, Ray Jones
School of Nursing and Midwifery
Abstract Background Robot pets may assist towards challenges of supporting an aging population with growing dementia prevalence. Prior work focused on impacts of robot seal Paro on older adult wellbeing, but recent studies suggest good acceptability and implementation feasibility of more affordable devices (Joy for All (JfA) cats and dogs), yet effectiveness research was limited. Methods We conducted an eight-month, stratified, cluster randomised controlled trial, in eight care homes in Cornwall, UK. Over four months, four care homes each received two JfA devices (one cat and dog), and four homes received care as usual (intervention and control group). Psychometrics were …
Caregiving Fathers In The Workplace: Organisational Experiences And The Fatherhood Forfeit, Jasmine Kelland
Caregiving Fathers In The Workplace: Organisational Experiences And The Fatherhood Forfeit, Jasmine Kelland
Plymouth Business School
This book explores the experiences of caregiving fathers in the UK. Conceptions of fatherhood, childcare, and work have altered over the last few decades, with many fathers taking a more active role in caregiving than before and seeking to alter their working patterns accordingly. However, such a wider involvement in caregiving for fathers can clash with traditional values about masculinity and work, which still hold sway over public opinion and workplace policies.Using quantitative and qualitative data, collected through the use of surveys, focus groups and semi-structured interviews with managers and working parents, the book explores perceptions and experiences of fathers …
Flexible Goal-Directed Manipulation Of Representations: Computational Models Of Healthy And Pathological Human Cognition, Giovanni Granato
Flexible Goal-Directed Manipulation Of Representations: Computational Models Of Healthy And Pathological Human Cognition, Giovanni Granato
School of Engineering, Computing and Mathematics Theses
The brain is able to manipulate itself, adapting its internal world in a changing environment. In particular it continuously manipulates its representations to achieve goals. This competence is supported by many neurocognitive high-order processes that interact during the performance of a goal-directed behaviour (e.g. attention processes, executive functions, motivational systems). Overall, adult humans often face a new problem trough a change of the `perceptual point of view' (i.e. a representational change), rather then an extended research of the correct action to perform. On the other hand, infants and children contemporary develop motor competence and task-directed perceptual representations (e.g. categorical perception). …
Buckling Behaviour Of Cold-Formed Steel Beams With Web Perforations, Nanting Yu
Buckling Behaviour Of Cold-Formed Steel Beams With Web Perforations, Nanting Yu
School of Engineering, Computing and Mathematics Theses
Cold-formed steel (CFS) members are widely used in the constructional industry, because CFS has high strength-to-weight ratio and can be easily fabricated into different shapes. In order to accommodate services like electric wires and pipelines, perforations are commonly punched into the web of CFS beams. However, the appearance of web openings may reduce the properties of the cross section and hence change the stress distribution along the longitude axis. As a result, the perforated cold-formed steel (PCFS) beam is more susceptible to lateral-torsional buckling. For specific cross sections controlled by distortional buckling, the restraint of web on the flange weakens …
Machine Learning-Based Exploration Of Blood-Based Biomarkers For Alzheimer’S Disease Diagnosis, Chima Stanley Eke
Machine Learning-Based Exploration Of Blood-Based Biomarkers For Alzheimer’S Disease Diagnosis, Chima Stanley Eke
School of Engineering, Computing and Mathematics Theses
Alzheimer’s disease (AD) is a neurodegenerative disease with typical clinical symptoms in the form of progressive cognitive impairment and memory loss. To facilitate early diagnosis of AD and a greater understanding of the mechanisms underlying its clinical expression, the use of biomarkers is necessary. Furthermore, it is believed that biomarkers provide a more objective and accessible means of diagnosis. Currently, established biomarkers include neuroimaging markers, such as those based on positron emission tomography (PET), and biochemical markers such as cerebrospinal fluid (CSF) markers. However, neuroimaging is expensive and may not be widely available and CSF testing is invasive. Blood-based biomarkers …
The Multi-Actor Perspective Of Engagement On Social Media, Sara Shawky, Krzysztof Kubacki, Timo Dietrich, Scott Weaven
The Multi-Actor Perspective Of Engagement On Social Media, Sara Shawky, Krzysztof Kubacki, Timo Dietrich, Scott Weaven
Plymouth Business School
Despite the known benefits offered by social media to create engagement in social marketing programs, scholars have highlighted the need for more evidence-based, practical, and measurable approaches to social media use in social marketing contexts. This netnographic study employed a four-level multi-actor engagement framework originally proposed by Shawky et al. to explore engagement in a single Facebook community. We identified social media measurement tools for assessing connections, interactions, and loyalty of multiple actors which will assist social marketing practitioners’ understanding of different actors’ interactions with the social media content, enabling them to maintain these actors’ levels of engagement, advance their …