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A Study Of The Molecular Immunogenetics Of Type 1 Diabetes In Man, Mohamed Mirza Jahromi Jan 2000

A Study Of The Molecular Immunogenetics Of Type 1 Diabetes In Man, Mohamed Mirza Jahromi

Other Faculty of Health Theses

Type 1 diabetes is caused by immune destruction of pancreatic β cells. There is increasing evidence that genes outside the MHC region contribute to the pathogenesis of type 1 diabetes. Cytokines due to their role in immune regulation seem to play a crucial role in the pathogenesis of the disease. Three hundred and eight patients with type 1 diabetes and 150 normal controls were genotyped for polymorphism in the genes for IFN-γ, IL-4, IL-6, and TGF-β1. All assays employed in this study were PCR based. The IFN-γ CA repeats was an octa-allelic repeat and the 3 / 3 genotype showed …

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Epidemiological Studies Of Childhood Onset Type 1 Diabetes In Devon And Cornwall, Hongxin Zhao Jan 2000

Epidemiological Studies Of Childhood Onset Type 1 Diabetes In Devon And Cornwall, Hongxin Zhao

Other Faculty of Health Theses

A high quality register of children with type 1 diabetes, The Cornwall and Plymouth Children's Diabetes Register (CPCDR), has been successfully established in the far South West of England for this thesis. Children aged 0-15 years of age who were diagnosed with type I diabetes in the study area have been systematically registered on the database since 01 /01/1975 until the present day. Children are now registered prospectively, to provide a database of the disease in this region and to allow epidemiological studies. Basic descriptive studies on the occurrence of the disease based on the CPCDR between 1975-1996 have been …

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The Effect Of Therapeutic Horsemanship Program On Emotionally Disturbed Boys, Alisa J. Greenwald Jan 2000

The Effect Of Therapeutic Horsemanship Program On Emotionally Disturbed Boys, Alisa J. Greenwald

Other Faculty of Health Theses

The relationships between humans and animals have been associated with various therapeutic implications. While there is no agreed upon name, the term "pet facilitated therapy" has become widely accepted. Pet facilitated therapy has been particularly adopted to describe the relationship between humans and domestic animals. In contrast to public attitudes of twenty years ago, the field of animal-human relationships is now respected as a legitimate area of research investigation (Levinson, 1982.) Numerous studies have been conducted on the benefits of the relationships between domestic animals and humans; however, there continues to be little empirical evidence that specifically addresses the relationship …

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Analysis Of Infragravity Frequency Sediment Transport On Macrotidal Beaches, Andrew Nicholas Saulter Jan 2000

Analysis Of Infragravity Frequency Sediment Transport On Macrotidal Beaches, Andrew Nicholas Saulter

Other Faculty of Science and Engineering Theses

Many cross-shore sediment transport models use simple treatments of infragravity frequency (0.005- 0.05Hz) processes. For example, infragravity waves have been assumed to provide solely a 'drift velocity' for transport of sediment mobilised by incident frequency waves (0.05-0.5Hz) and be 100% reflected at the shoreline. Furthermore, numerous models calculate broken incident wave heights on the basis of water depth only. This work investigates both the processes underlying infragravity frequency variations in the crossshore velocity field, and the resulting effect of such variations on sediment suspension and transport. Data were selected from three beach experiments in order to compare observations from a …

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A Regional Coastal Zone Management System, Victor James Abbott Jan 2000

A Regional Coastal Zone Management System, Victor James Abbott

Other Faculty of Science and Engineering Theses

This thesis documents research undertaken to investigate the operation of coastal zone management in and around south Devon in the south west of the United Kingdom. The concept of coastal zone management has brought an integrated approach to the coastal zone in many placed around the world and examples of these are given (Chapter Two) to illustrate the mature nature of coastal zone management in these places. These are contrasted with the current UK use of a sectoral rather than a holistic approach.

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Small Towns And The Rural Economy : A Study Of Their Contemporary Functions And Potential Role In Rural Development, Paul Richard Courtney Jan 2000

Small Towns And The Rural Economy : A Study Of Their Contemporary Functions And Potential Role In Rural Development, Paul Richard Courtney

Other Faculty of Science and Engineering Theses

As Rural Development assumes a greater importance in European policy, one strategy to stimulate economic activity across a broad range of sectors is to use small towns as a focal point for economic development. This may be particularly relevant in the UK where there is increasing concern over the future vitality and viability of these towns. However, such a strategy rests on the assumption that there is a strong level of interdependence between small towns and their surrounding areas. While their historical legacy suggests close integration, developments in the wider economy and resultant socio-economic restructuring have undermined the traditional functions …

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Emission, Dispersion And Local Deposition Of Ammonia Volatilised From Farm Buildings And Following The Application Of Cattle Slurry To Grassland, Richard Alexander Hill Jan 2000

Emission, Dispersion And Local Deposition Of Ammonia Volatilised From Farm Buildings And Following The Application Of Cattle Slurry To Grassland, Richard Alexander Hill

Other Faculty of Science and Engineering Theses

Emissions of ammonia (NH3) into the atmosphere, principally from agricultural sources, have been implicated in the pollution of forests, moorlands and grasslands, through the subsequent deposition of reduced nitrogen (NHx -N). Consequently, legislation has been implemented to control both the transboundary transport and local environmental impacts of NHx. This thesis investigates the emission, dispersion and local deposition of NH3 from two sources that are major components of national NH3 emissions inventories, slurry applied to grassland and naturally ventilated cattle buildings. A N balance method was identified for determining the time-average deposition of NH3 downwind of a farm building, whilst an …

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Analysis Of Marketing Strategies In Polish Ports, Aleksandra Urszula Pieczek Jan 2000

Analysis Of Marketing Strategies In Polish Ports, Aleksandra Urszula Pieczek

Other Faculty of Science and Engineering Theses

The service sector of economy is a field of growing interest to marketing research and in particular such services as provided by seaports. However, these activities have rarely been considered to date. This project consists of three parts. Firstly a review of service marketing approaches, their status and development, the nature of marketing strategies and the marketing mix had to be provided. Also the development of marketing in seaports had to be examined. The focal elements discussed were the elements of the services provided by seaports, and competition between them in the context of Poland Secondly the situation in Eastern …

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The Thermal Properties Of Cob Buildings Of Devon, Steve Goodhew Jan 2000

The Thermal Properties Of Cob Buildings Of Devon, Steve Goodhew

Other Faculty of Science and Engineering Theses

Little has been published concerning the thermal properties of existing unbaked earth walls. In order to model the thermal behaviour of a building constructed using traditional cob walls, the thermal conductivity and thermal diffusivity need to be established. The Centre for Earthen Architecture (CEA), based at the University of Plymouth's School of Architecture has carried out research into various aspects of cob architecture typical to the Devon area. This study supplements other work concerning the moisture content, structure and pathology of cob as a building material. This research concentrates upon the development of a time dependent probe technique for the …

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Live Interpretation: An Asset, Or An Indulgence? In The Fields Of Education And Entertainment, How Valuable Is Live Interpretation As An Effective Tool Of Communication?, Dawn Helen Stevens Jan 2000

Live Interpretation: An Asset, Or An Indulgence? In The Fields Of Education And Entertainment, How Valuable Is Live Interpretation As An Effective Tool Of Communication?, Dawn Helen Stevens

Other Faculty of Arts, Humanities and Business Theses

This thesis aims to assess the value of live interpretation as a tool of communication, by treating it as a form of design, and by comparing examples of practice in the field with other contemporary design techniques. Chapter two lists a selection of active practitioners across the field of informal and formal education, and entertainment within the area of Britain's cultural heritage. It provides a taste of the professional industry, and includes information like how many interpreters are employed, what techniques they favour, and what educational programmes they run. Likewise in the voluntary /hobbyist sector, the chapter notes membership numbers, …

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The Architectural Expression Of Anglican Rituals As Disseminated Through A Photographic Enquiry Of Six Devon Churches, Simon Standing Jan 2000

The Architectural Expression Of Anglican Rituals As Disseminated Through A Photographic Enquiry Of Six Devon Churches, Simon Standing

Other Faculty of Arts, Humanities and Business Theses

There have been a number of publications that have set out to clarify the relationship between architectural, liturgical and ritual developments within the nineteenth century Anglican church; especially that part of the Victorian Gothic Revival where fundamental developments in architectural design and doctrinal change occurred - 1840 to 1900. A variety of graphic illustrations have supported these texts and as a photographer who has had a long standing interest in visual forms of religious expression, it has raised the question as to whether new meanings of the architectural/ecclesiastical relationship could be established through a photographic-based research investigation. During the MPhil …

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Writing The Real: The Collages Of Hannelore Baron, Valerie James Reardon Jan 2000

Writing The Real: The Collages Of Hannelore Baron, Valerie James Reardon

Other Faculty of Arts, Humanities and Business Theses

Baron's work has not been extensively studied nor is it known in full. Critical writings and scholarly attention have focused on the work as representative of Holocaust suffering. This thesis intervenes in that assumption by arguing that it is possible to understand Baron's processes of making collage as a significant case study in the problematic of signification and a complex of differences none of which are reducible to or deducible from each other. Drawing together a range of biographical information, primary source material and close readings of many of Baron's collages (including two hitherto unseen series) traces are revealed of …

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Criminality Of Women In The 18th Century In The South West Of England, Amy Alexander Williams Jan 2000

Criminality Of Women In The 18th Century In The South West Of England, Amy Alexander Williams

Other Faculty of Arts, Humanities and Business Theses

Chapter 1: Debates and Developments in the fields of Crime History and Women's History: Frameworks, Methodolozies and Consolidation. This chapter falls into three sections. The first outlines some key issues in Crime History. The second examines the development of women's history and discusses the introduction of gender into Crime History. It is argued that the new issues that have arisen from the joining of these two disciplines have enhanced the development of Crime History. The third section discusses women's history and the study of crime and gender in the early modem period, the source material used and methodology employed in …

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Acts Of Writing: Writings On Contemporary Performance, Richard David Allsopp Jan 2000

Acts Of Writing: Writings On Contemporary Performance, Richard David Allsopp

Other Faculty of Arts, Humanities and Business Theses

The work published between 1992- 2000 and presented here forms a continuing meditation on, and exploration of contemporary performance. The term 'contemporary performance' is used to refer to practices and discourses in the performance arts that have occurred over the last decade. There is a particular emphasis on those unstable, hybrid and interdisciplinary areas of performance (including performance art, installation, 'new' dance, 'experimental' theatre, 'live' art) which resist easy definition or categorisation, and which may be further characterised as postmodern in the sense of a reflexive, contextualised and knowingly problematic practice. More specifically the work builds a sustained thesis on …

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The Mechanism Of Action Of Liquid Seaweed Extracts In The Manipulation Of Frost Resistance In Winter Barley (Hordeum Vulgare. L), Stephen Burchett Jan 2000

The Mechanism Of Action Of Liquid Seaweed Extracts In The Manipulation Of Frost Resistance In Winter Barley (Hordeum Vulgare. L), Stephen Burchett

Other Faculty of Science and Engineering Theses

Frost assays carried out on winter barley (Hordeum vulgare cv Igri) showed that a single (10ml I) application of liquid seaweed extract (LSE) marginally increased the frost resistance of non-acclimated (NA) plants by 2.3% compared to NA controls and cold-acclimated (CA) plants by 2.1% compared to CA controls. Three applications of LSE increased the frost resistance of NA plants by 16% compared to NA controls and CA plants by 7.5% compared to CA controls. These observations were durable in a small scale field trial where LSE increased plant dry weights (control 0.55, single LSE, 0.611 and multiple LSE 0.621 log …

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South Asian Divorce And Disputes Involving Children Of South Asian Origin, William Hay Jan 2000

South Asian Divorce And Disputes Involving Children Of South Asian Origin, William Hay

Other Faculty of Arts, Humanities and Business Theses

This thesis is concerned with two discrete but related themes that are of considerable socio-legal significance: South Asian divorce and disputes involving South Asian children. Both themes are explored empirically by means of a qualitative research study conducted in an urban and industrial area of Britain with a high South Asian population. The thesis thus seeks to provide much needed information concerning what are currently two poorly understood social problems. The material is presented in three main sections. The first section provides the wider context to the study including a discussion of the changing face of South Asian social relations …

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The Disappearing Frame.: A Practice-Based Investigation Into Composing Virtual Environment Artworks, Thomas James Patrick Corby Jan 2000

The Disappearing Frame.: A Practice-Based Investigation Into Composing Virtual Environment Artworks, Thomas James Patrick Corby

Other Faculty of Arts, Humanities and Business Theses

Through creative art making practice, research seeks to contribute a body of knowledge to an under researched area by examining how key concepts germane to computer based, interactive, three-dimensional, virtual environment artworks might be explicated, potential compositional issues characterised, and possible production strategies identified and/or proposed. Initial research summarises a range of classifications pertaining to the function of interactivity within virtual space, leading to an identification and analysis of a predominant model for composing virtual environment media, characterised as the "world as model": a methodological approach to devising interactive and spatial contexts employing visual and behavioural modes based on the …

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Processing Writing: From Text To Textual Interventions, Caroline Bergvall Jan 2000

Processing Writing: From Text To Textual Interventions, Caroline Bergvall

Other Faculty of Arts, Humanities and Business Theses

This submission comprises the main bulk of the critical and textual work I have researched and developed over the last five years. Throughout this period, I have been particularly interested in exploring issues of interdisciplinarity for writers and text-practitioners, at both a critical and a methodological level. An interest in cross-media and site-related approaches to writing plays an important role in this. This is reflected in the thematics of the various critical texts, as well as in the fairly broad range of textual modes submitted. As a whole, this work can be seen in close continuity with my pedagogical involvement …

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The Relationship Between Teachers' Understanding Of The Nature Of Science And Their Science Practice : Four Case Studies From An Urban Primary School., Stephen Laurence Waters-Adams Jan 2000

The Relationship Between Teachers' Understanding Of The Nature Of Science And Their Science Practice : Four Case Studies From An Urban Primary School., Stephen Laurence Waters-Adams

Plymouth Institute of Education Theses

This thesis explores the relationship between a teacher's understanding of the nature of science and her practice. The idea that teachers' understanding of the nature of science is a powerful determinant of their actions in the classroom has a strong intuitive appeal. Research over the last forty years has provided inconclusive results; however, there is a clear implication within recent central policy on teacher education that such knowledge should translated directly into practice. This has led to the identification within teacher training, materials of specific expectations regarding understanding of the nature of science (DfEE 1998a). This thesis presents four case …

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A Study Of Trust And Commitment Amongst Nursing Staff Within Nhs Organisations, Thomas Joseph Mccabe Jan 2000

A Study Of Trust And Commitment Amongst Nursing Staff Within Nhs Organisations, Thomas Joseph Mccabe

Plymouth Business School Theses

Much academic research supposes that there is a relationship between the level of trust amongst employees and their managers and the extent to which employees are committed, in terms of their attitudes and their behaviour towards the aims and objectives of the organisation and their daily tasks and duties (Kanter, 1972; Eisenstadt and Roniger, 1984; Geller 1988, Guest, 1991; Morgan and Hunt, 1994; Fine and Holyfield, 1996; Brocker, et al, 1997). This study has sought to explore and assess the level and nature of trust and the sources and the conditions which create trust between nursing staff and their managers …

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Mental Models, Cognitive Style, And Organisational Learning : The Development Of Shared Understanding In Organisations, David Philip Spicer Jan 2000

Mental Models, Cognitive Style, And Organisational Learning : The Development Of Shared Understanding In Organisations, David Philip Spicer

Plymouth Business School Theses

Organisational learning is seen by many to be a key determinant of organisational performance. This is demonstrated by the growth of the 'learning company' concept (Pedler et al. 1991), and by the suggestion that the ability to learn faster than one's competitors is the only sustainable competitive advantage (DeGeus 1988). Consequently, organisations need to integrate and maximise the knowledge and learning of their individuals, and central to the learning process in firms is an effective means of transferring knowledge and learning between individuals and their organisation as a whole. Mental models (individual and shared) have been postulated as a mechanism …

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The Enforcement Of Environmental Law In England And Wales, Lisa Jane Page Jan 2000

The Enforcement Of Environmental Law In England And Wales, Lisa Jane Page

Plymouth Business School Theses

The control of environmentally damaging activities has become one of the most important areas for concern in recent years. The amount of legislation relating to this subject area has increased several-fold, with European Directives and domestic laws being introduced in response to pressure from a variety of avenues. Key studies on the enforcement of environmental law have been carried out. However, this work was undertaken prior to the expansion of legislative provisions at the start of the 1990s. In the light of this new legislation, new regulatory agencies, and changing public opinion, the following research aims were formulated: 1. To …

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The Influence Of Advertising Approach In A Trial Purchase Context, Sarah Ann Claydon Jan 2000

The Influence Of Advertising Approach In A Trial Purchase Context, Sarah Ann Claydon

Plymouth Business School Theses

Research investigating the development of trial purchase has recognised that the chosen advertising approach is a key influence in the trial process. This thesis describes a critique of the central and related literature surrounding the influence of advertising approach in a trial purchase context, with particular emphasis on the concept of disruptive advertising. This concept can be described as an overturning of convention for commercial benefit, and has been introduced to deal with change. Whilst it is clear that many brands achieve success via a consistent approach to advertising, it is also true that successful advertising is often rooted in …

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Enviropreneurial Management An Effective Approach To Cope With The Ecological Challenge, Ljiljana Mitic Jan 2000

Enviropreneurial Management An Effective Approach To Cope With The Ecological Challenge, Ljiljana Mitic

Plymouth Business School Theses

Humankind is the major force influencing our planet earth. Irreversible environmental degradation are a widespread problem. Atmospheric changes, worsening climate, ozone depletion, etc. is accompanying our daily life. From the ecological perspective the future of the 21st century is endangered. A change of consumption pattern, material thinking, lifestyles have to change fundamentally. lt may even require to break with 'business-as-usual'. In the age of continuously and rapidly changing compet1t1ve environments, companies are increasingly forced to be highly flexible and responsive to changes having an impact on their competitiveness or even affecting the firm's viability. "Entrepreneurship" is an emerging practice, which …

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User-Centred Methods In The Analysis And Design Of Software Tools To Support Management Consultants, Mark Dixon Jan 2000

User-Centred Methods In The Analysis And Design Of Software Tools To Support Management Consultants, Mark Dixon

School of Engineering, Computing and Mathematics Theses

The aim of the present work was to investigate the development of improved software tools for management consultants, and to investigate the effectiveness of augmented user-centred methods in this development, and thereby consider the more general use of augmented user-centred methods to develop software tools that support creative human activity systems. The research method used draws from and integrates aspects of user-centred design, soft systems methods, structured systems analysis and design, and software engineering. This includes using user literature, 'thinking aloud' role play observations, and interviews to develop a user model of the management consultancy process; using literature of related …

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Evolutionary Decomposition Of Complex Design Spaces, Christopher Richard Bonham Jan 2000

Evolutionary Decomposition Of Complex Design Spaces, Christopher Richard Bonham

School of Engineering, Computing and Mathematics Theses

This dissertation investigates the support of conceptual engineering design through the decomposition of multi-dimensional search spaces into regions of high performance. Such decomposition helps the designer identify optimal design directions by the elimination of infeasible or undesirable regions within the search space. Moreover, high levels of interaction between the designer and the model increases overall domain knowledge and significantly reduces uncertainty relating to the design task at hand. The aim of the research is to develop the archetypal Cluster Oriented Genetic Algorithm (COGA) which achieves search space decomposition by using variable mutation (vmCOGA) to promote diverse search and an Adaptive …

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A Predictive Fuzzy-Neural Autopilot For The Guidance Of Small Motorised Marine Craft, Ralph Richter Jan 2000

A Predictive Fuzzy-Neural Autopilot For The Guidance Of Small Motorised Marine Craft, Ralph Richter

School of Engineering, Computing and Mathematics Theses

This thesis investigates the design and evaluation of a control system, that is able to adapt quickly to changes in environment and steering characteristics. This type of controller is particularly suited for applications with wide-ranging working conditions such as those experienced by small motorised craft. A small motorised craft is assumed to be highly agile and prone to disturbances, being thrown off-course very easily when travelling at high speed 'but rather heavy and sluggish at low speeds. Unlike large vessels, the steering characteristics of the craft will change tremendously with a change in forward speed. Any new design of autopilot …

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Design Models For Multimedia Learning Environments Based On Interactive Drama, Thomas John Rogers Jan 2000

Design Models For Multimedia Learning Environments Based On Interactive Drama, Thomas John Rogers

School of Engineering, Computing and Mathematics Theses

Interactive multimedia offers a degree of richness that lies outside the scope of conventional design methods for computer based learning. This research seeks to develop an interdisciplinary approach to design, that recognises the ways in which the combination and integration of different media forms can be exploited to stimulate experiential, intuitive, perceptual, and social/communicative aspects of learning. The goal of the project has been to develop a conceptual design model for the development of multimedia learning environments (MLEs), for humanistic learning applications, by using interactive drama. The models and methods developed though a practical design project have been founded upon …

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Towards A New Framework For Product Development, Aj Robotham, Tc Mcaloone Jan 2000

Towards A New Framework For Product Development, Aj Robotham, Tc Mcaloone

School of Engineering, Computing and Mathematics

No abstract provided.

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What Is The New Paradigm In Product Quality?, Aj Robotham, M Guldbrandsen Jan 2000

What Is The New Paradigm In Product Quality?, Aj Robotham, M Guldbrandsen

School of Engineering, Computing and Mathematics

No abstract provided.

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