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P-Glycoprotein-Associated Anthracycline Resistance In B-Cll: Potential For Cytokine Modulation, Varinia Graciela Munoz-Ritchie Jan 2001

P-Glycoprotein-Associated Anthracycline Resistance In B-Cll: Potential For Cytokine Modulation, Varinia Graciela Munoz-Ritchie

Other Faculty of Health Theses

The phenomenon of multidrug resistance (MDR) in cancer cells is generally associated with P-glycoprotein (P-gp) expression and presents an obstacle to successful chemotherapy. Attempts to overcome P-gp-associated MDR using P-gp modulators, such as verapamil, have been hindered by their intrinsic in vivo toxicity. In 1991, however, Scala et al. demonstrated the alteration of P-gp function by interferon-alpha (IFN-α) in vitro at non-toxic in vivo concentrations, suggesting a basis for the use of IFN-α clinically in patients exhibiting P-gp-associated MDR. Drug resistance in B-CLL has been linked to the phenomenon of MDR, however, publications regarding this have been conflicting. The contrasting …

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Interagency Coordination And Collaboration In The Management Of Child Sexual Abuse: In Australian And England, Anne Margaret Lawrence Jan 2001

Interagency Coordination And Collaboration In The Management Of Child Sexual Abuse: In Australian And England, Anne Margaret Lawrence

Other Faculty of Health Theses

This thesis focuses on interagency coordination and collaboration in the management of child sexual abuse in Australia and in England. The impetus for the research arose from the experience of the author as manager and practitioner in the area of child sexual abuse, while working in these two countries. Problems regarding the management of interagency cooperation had become apparent in child protection practice and were also recognized in the literature. Personal experience, as well as a review of the literature, revealed that there was a need for the identification and validation of the key mechanisms and processes underlying effective interagency …

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Prophylaxis Of Disease Caused By Bacterial Pathogens Of Man, Richard William Titball Jan 2001

Prophylaxis Of Disease Caused By Bacterial Pathogens Of Man, Richard William Titball

Other Faculty of Health Theses

This thesis reports research undertaken which will lead to improved pretreatments and therapies for disease caused by Clostridium perfringens, Francisella tularensis, Yersinia pestis and Burkholderia pseudomallei. C. perfringens is thought to be the most widely distributed bacterial pathogen and is the most important Clostridial species associated with enteric disease in domesticated animals. During warfare C. perfringens has been a significant causes of mortality. Between 1 and 10% of wounded personnel developed gas gangrene during the 1st and 2nd world wars. The ability of the bacterium to cause a range of diseases is due largely to the differential production of toxins. …

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Cytokine Expression In Patients With B-Cell Chronic Lymphocytic Leukaemia, Anna Kaminski Jan 2001

Cytokine Expression In Patients With B-Cell Chronic Lymphocytic Leukaemia, Anna Kaminski

Other Faculty of Health Theses

B-cell chronic lymphocytic leukaemia (B-CLL) results from a clonal accumulation of CD5+ve B-lymphocytes. This expansion of B-lymphocytes is due to increased proliferation and extended survival secondary to decreased apoptosis. Both proliferation and apoptosis are regulated by a group of soluble proteins, termed cytokines, which are secreted by cells and play a key role in the regulation of immunological responses. In view of this, the role of cytokines in the pathogenesis of B-CLL was studied. Interleukin 4 (IL-4) is an anti-apoptotic cytokine which up-regulates bcl-2 in malignant B-lymphocytes. Peripheral blood samples, from untreated B-CLL patients were investigated, together with a group …

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A Study Of The Role Of Cytokines In Acute Pancreatitis In Man, Alison Marie Smithies Jan 2001

A Study Of The Role Of Cytokines In Acute Pancreatitis In Man, Alison Marie Smithies

Other Faculty of Health Theses

Introduction: Acute pancreatitis is an inflammatory disease with a diverse aetiology and variableclinical course. The IL-l gene cluster has been implicated in this disease.Aims: The aims of the study were to investigate polymorphisms of the genes encoded within the IL-lgene cluster in patients with acute pancreatitis and normal controls and to determine therelationship between the polymorphisms and protein levels.Methods: Genotype and allele frequencies were determined in controls (n=217) and patients withacute pancreatitis (n=137) using the polymerase chain reaction (PCR) followed by digestion withrestriction endonucleases where applicable. Protein levels were determined using in vitrostimulation of PBMCs followed by Enzyme Linked Immunosorbent …

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Study Of The Effect Of Turbulence On The Properties Of Flocculated Mud, Andrew Manning Jan 2001

Study Of The Effect Of Turbulence On The Properties Of Flocculated Mud, Andrew Manning

Other Faculty of Science and Engineering Theses

For the successful management of an estuary, an accurate simulation model predicting sediment transport patterns is a necessity. This requires a knowledge of the vertical mass settling flux (MSF), which is the product of the suspended particulate matter (SPM) concentration and the settling velocity (Ws). However the presence of cohesive sediments (i.e. mud) complicates this description due to the ability of mud particles to flocculate into larger aggregates (floes) which demonstrate faster settling velocities and lower effective densities (pe) than the component cohesive particles. The generation of turbulent shear stress (TSS) within the water column is regarded as having a …

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The Synthesis Of Estuarine Bathymetry From Sparse Sounding Data, Janet Eirlys Burroughes Jan 2001

The Synthesis Of Estuarine Bathymetry From Sparse Sounding Data, Janet Eirlys Burroughes

Other Faculty of Science and Engineering Theses

The two aims of the project involved: 1. Devising a system for prediction o f areas of bathymetric change within the Fal estuary 2. Formulating and evaluating a method for interpolating single beam acoustic bathymetry to avoid artefacts o f interpolation. In order to address these aims, sources of bathymetric data for the Fal estuary were identified as Truro Harbour Office, Cornwall County Council and the Environment Agency. The data collected from these sources included red wavelength Lidar, aerial photography and single beam acoustic bathymetry from a number of different years. These data were input into a Geographic Information System …

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The Relationship Between Livestock Distribution Channels And Animal Welfare, Karen Christina Murray Jan 2001

The Relationship Between Livestock Distribution Channels And Animal Welfare, Karen Christina Murray

Other Faculty of Science and Engineering Theses

Major changes are taking place in all sectors of the livestock and meat producing industries from farm to consumer which impinge on the processes and patterns of livestock distribution from farm to slaughter. These changes are identified and described. A survey of the complete journeys from farm to abattoir of 18,393 slaughterweight lambs sold direct from farm to abattoir, via livestock auction markets and via electronic auctions was conducted. Lambs sold direct from farm to abattoir experienced shorter journeys (in terms of both median duration and distance) than lambs sold through either of the other two channels. Lambs sold through …

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Implementing Marine Pollution Policy : Proposals For Change, Jonathan Peter Richards Jan 2001

Implementing Marine Pollution Policy : Proposals For Change, Jonathan Peter Richards

Other Faculty of Science and Engineering Theses

This study aims to determine the factors that affect the implementation of marine pollution policy, especially with regard to regulation of the hazardous substances which contaminate the marine environment- The purpose is to identify weaknesses in the current regulatory regime and to propose improvements. The study also aims to develop a new strategic framework for the implementation of the recent international policy commitments, which call for the complete cessation of discharges of hazardous substances into the marine environment by the year 2020. Furthermore, the study seeks to provide evidence to support or challenge current theories relating to regulation and policy …

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Developments And Benefits Of Liquid Feeding Through Fermentation For The Post-Weaned Pig, Colm Anthony Moran Jan 2001

Developments And Benefits Of Liquid Feeding Through Fermentation For The Post-Weaned Pig, Colm Anthony Moran

Other Faculty of Science and Engineering Theses

A programme of study was undertaken to assess the safety and palatability of fermented liquid feed. A series of laboratory experiments was conducted to select an inoculant capable of fermenting liquid feed at 20°C. Whilst combinations of cultures dropped the pH the most rapidly, the Lb. plantarum (PC) strain decreased the pH the lowest. A series of trials were conducted using a rifampicin mutant of Lb. plantarum (PC) to examine the fate of the starter culture. In an experiment using liquid milled wheat the addition of the starter culture resulted in an improvement in the inhibition of coliforms over the …

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Music In Reality The Relation Of Music, Emotion And Pre-Socratic Myth, Brian Capleton Jan 2001

Music In Reality The Relation Of Music, Emotion And Pre-Socratic Myth, Brian Capleton

Other Faculty of Arts, Humanities and Business Theses

This thesis is in two sections. The first critically examines the tradition of harmonia mundi. The earliest complete and developed account of musica mundana appears in Plato, but numerous fragmented references appear in the pre-Socratic sources. The notion that harmonia mundi originated as an idea of quantitative speeds and distances of the celestial bodies, is discredited. Rather, it is shown that it more probably originates as an expression of an 'esoteric spiritual' teaching in which self-knowledge, death, the concept of harmonia, and consequently music, are related. The idea that the greatest importance of music rests on the relationship of music …

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The Importance Of Being : The Autobiographical Subject In The Drama And Memoirs Of Ronald Duncan, Anna Claire Trussler Jan 2001

The Importance Of Being : The Autobiographical Subject In The Drama And Memoirs Of Ronald Duncan, Anna Claire Trussler

Other Faculty of Arts, Humanities and Business Theses

This study developed after considerable time spent collating and cataloguing data contained in Ronald Duncan's archive. Familiarisation with the material led to my identifying a need to explore the elusive nature of the personality that biographical material should hope to uncover. Duncan was prone to mainly confessional writing, a kind of writing that demands a causal inference between life and work. Furthermore, the archive supplies multiple data sources that serve to aid chronology, trace reliability, provide external corroboration and investigate truth-value. My study follows a loosely chronological structure after discerning shifts in his thematic concerns. The years up until the …

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Designing A Visual Component Of Communication Within 3d Avatar Virtual Worlds, Nicholas John Earle Jan 2001

Designing A Visual Component Of Communication Within 3d Avatar Virtual Worlds, Nicholas John Earle

Other Faculty of Arts, Humanities and Business Theses

Over the last few years 3D avatar virtual worlds (AVW) have emerged on the Internet. These are computer generated, multi-user, graphical spaces within which people meet, form social groups and interact with each other in real time, typically through the exchange of text or audio messages. Each user is represented within the space by a digital image known as an avatar, which is usually humanoid in form, and is predominantly under the control of the person it represents. This thesisd escribesa creativep roject that is concernedw ith aspectso f social communication between users of "Ws. In particular, an avatar is …

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Poetic Anatomy Of The Numinous Creative Passages Into The Self As Beloved, Partou Zia Jan 2001

Poetic Anatomy Of The Numinous Creative Passages Into The Self As Beloved, Partou Zia

Other Faculty of Arts, Humanities and Business Theses

This research is shaped by the actual experience of practice: as painter and writer. My preoccupation is with the nodal moment when conscious awareness is suspended, and both the corporal and psychic involvement in realising the work almost transport one to another zone of effectiveness. This zone, which I name as the poetic zone, is where the numinous enters the ordinary. The investigation for a space/place/moment that lies beyond the logic of acceptable discourse can help initiate and give shape to a new vocabulary - visual or literary. By orchestrating a methodology, which functions on several layers, I have endeavoured …

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From Rio To Romola: Morality And Didacticism In The English Appreciation Of Early Italian Art 1836-1863, Matthew T.W. Plampin Jan 2001

From Rio To Romola: Morality And Didacticism In The English Appreciation Of Early Italian Art 1836-1863, Matthew T.W. Plampin

Other Faculty of Arts, Humanities and Business Theses

This thesis takes as its starting point the marked rise in interest in the earlier schools of Italian painting in the English art world during the 1840s. Over the course of this decade the study and collection of so-called 'primitive' painting was transformed from a marginal pursuit to an aspect of mainstream taste. The thesis defines the critical discourse formulated in order to rationalise the taste for art works which failed to conform to the principles which had governed the appreciation of old master painting in previous decades. It also studies the ramifications of this discourse with regards to broader …

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An Investigation Into The Factors Determining Ruminant Livestock Distribution In The Far South West, Dafydd Huw Davies Jan 2001

An Investigation Into The Factors Determining Ruminant Livestock Distribution In The Far South West, Dafydd Huw Davies

Other Faculty of Arts, Humanities and Business Theses

Major changes are taking place in all sectors of the livestock and meat producing industries from farm to consumer which impinge on the processes and pattems of livestock distribution from farm to slaughter. These changes are identified and described. A farm business survey of lowland beef and sheep finishers was undertaken, prior to the 2001 Foot and Mouth outbreak, to gain a better understanding of farm business behaviour in order to model the farm business strategies in relation to aggregate livestock channel utilisation. Statistically robust and predictive models using a number of derived latent strategic variables, distilling marketing and business …

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Methodological Embodiments:: Psychical Corporeal Performances Of Subjective Specific Auto[Erotic)-Representations, Ryya Aviva Sanders Jan 2001

Methodological Embodiments:: Psychical Corporeal Performances Of Subjective Specific Auto[Erotic)-Representations, Ryya Aviva Sanders

Other Faculty of Arts, Humanities and Business Theses

A great deal of critical attention has been paid over the last twenty years at least to the relation of 'self and 'Other'. But what happens when the external 'other' is displaced to the periphery of the concerns of textual production? In order to explore this question Methodological Embodiments employs an interdisciplinary praxis that is not limited to the classic model of written theory. At the same time, it does not negate this form that has historical and ideological precedence within an academic context. The aim of this thesis is to juxtapose written theory with artistic practices in order to …

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Fatigue Of A Spring Steel With Varying Levels Of Non-Metallic Inclusions, Alan Edwin Lee Holman Jan 2001

Fatigue Of A Spring Steel With Varying Levels Of Non-Metallic Inclusions, Alan Edwin Lee Holman

Other Faculty of Science and Engineering Theses

Plain specimens of two batches of the commercial spring steel BS 251A58 of nominally identical processing but significantly differing levels of non-metallic inclusion levels, have been tested in rotating bending. The data produced has been analysed against some recent methods for the prediction of fatigue properties in high strength materials containing defects. The materials tested were specifically selected for their disparate cleanliness levels, yielding specimens with differing inclusion distribution and maxima. The morphology of critical inclusions is identical between the two material batches. Material microstructure is tempered martensite with ultimate tensile strength of approximately 2000 MPa, which renders it well …

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Studies In Agricultural Technology In Nineteenth- And Twentieth-Century England, Paul William Brassley Jan 2001

Studies In Agricultural Technology In Nineteenth- And Twentieth-Century England, Paul William Brassley

Other Faculty of Science and Engineering Theses

Four published papers and several parts of a book are presented herein, together with a previously unpublished short paper explaining the intellectual background against which they were written and summarising their findings on the development of agricultural teQmology in England in the nineteenth and twentieth centuries. This outlines the contribution of economic and sociological the^pries to the study of technical change, but makes the point that historical studies, although clearly influenced by these theories, tend to use a multifactorial approach which avoids privileging any single explanation. Nevertheless, several themes arising in all of this material are identified, especially the gap …

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The Decision To Undertake Vocational Higher Education In Shipping And Logistics In The Uk, John Dinwoodie Jan 2001

The Decision To Undertake Vocational Higher Education In Shipping And Logistics In The Uk, John Dinwoodie

Other Faculty of Science and Engineering Theses

This work investigates the decision to study shipping and logistics at advanced levels in the UK. Documented evidence reports and analyses the perceptions of students on vocational courses in shipping, transport and logistics and investigates why they chose their particular fields of study. A range of instruments are presented to analyse how students perceived that they had arrived at their study decisions, including national surveys of undergraduates in maritime business, postgraduates in shipping and logistics and professionals contemplating updating short courses. Qualitative, quantitative and mapping methods are presented along with perceptions of relevant professional outcome roles and other factors. Exploratory …

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The Resistance To Salt Of Brassica Sps. And Improved Resistance By Direct Selection And Mutagenesis, Manal Hassan Eed Jan 2001

The Resistance To Salt Of Brassica Sps. And Improved Resistance By Direct Selection And Mutagenesis, Manal Hassan Eed

Other Faculty of Science and Engineering Theses

Salinity is one of the most serious environmental stresses influencing agriculture drastically decreasing the production of crop plants throughout the world. Due to salinity thousands of hectares of agricultural land are going out of production annually. To cope with the salinity problem, there is keen interest in the development of crop plants displaying resistance to the effects of salinity. A series of experiments was carried out under controlled environmental conditions to determine salt resistance in Rapid Cycling Brassica species (RCB's) at germination early seedling and late growth stage. The effect of increasing salinity concentration was determined in vivo using a …

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Phonographies: Practical And Theoretical Explorations Into Composing With Disembodied Sound, John Levack Drever Jan 2001

Phonographies: Practical And Theoretical Explorations Into Composing With Disembodied Sound, John Levack Drever

Other Faculty of Arts, Humanities and Business Theses

This is PhD submission is both practical and theoretical. The practical element consists of nine electroacoustic compositions. The dissertation acts as a discursive accompaniment to the compositions, addressing many of the contextual and philosophical issues that have arisen during the compositional process and the perfannance of the works. It charts out discourse surrounding the different genres of electroacoustic music that the works relate to as well as examining models of work in the respective genres (i. e. sonic art, text.. sound, acousmatic composition, inusique concrite and soundscape composition), and places them into a broader cultural and historical context. Chapter 2 …

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Biomarkers Relevant To Oil And Gas Industrial Activities In Low Temperature Marine Ecosystems, Lionel Andre Yves Camus Jan 2001

Biomarkers Relevant To Oil And Gas Industrial Activities In Low Temperature Marine Ecosystems, Lionel Andre Yves Camus

School of Biological and Marine Sciences Theses

Because of its geographical location, the Arctic environment is considered as pristine. However, expanding industrial activities in the Arctic require assessment of the toxicity of chemicals at low temperature. Biomarkers defined as "biological responses to a chemical or chemicals that give a measure of exposure or toxic effect" were shown to be relevant to measure in situ impact of oil discharges. Most biomarker studies have been performed with temperate organisms. The Arctic is characterised by low stable temperature, strong seasonality in light, resulting in a short primary production in Spring. Therefore, indigenous organisms have developed specific adaptations to live with …

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Team Player Styles, Team Design Variables And Team Work Effectiveness In Egypt, Ghada Awed Hassan El-Kot Jan 2001

Team Player Styles, Team Design Variables And Team Work Effectiveness In Egypt, Ghada Awed Hassan El-Kot

Plymouth Business School Theses

The literature has revealed few studies of management in Arab countries in general and particularly in Egypt. Many Egyptian organisations implemented the team concept a number of years ago, however, there do not appear to be any studies investicitaýt inc",D team work effectiveness in Egypt. The literature review and the findings of a pilot study emphasised the need for empirical research in team work in Egypt. Team effectiveness models are examined in order to identify the factors that may enhance team effectiveness in Egypt. Team behavioural models are also examined to identify the importance of balanced team membership and its …

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Disclosure In Annual Reports: An Agency Theoretic Perspective In An International Setting, Mohd Ismail Bin Ramli Jan 2001

Disclosure In Annual Reports: An Agency Theoretic Perspective In An International Setting, Mohd Ismail Bin Ramli

Plymouth Business School Theses

Over the recent years 'transparency' or better information disclosure has been the buzzword of various corporate governance bodies due to the failures of the system of corporate governance, which arise from an agency relationship. However, there are arguments by 'free market' advocates suggesting that information is voluntarily disclosed. This study discusses and compares the disclosure of information relating to directors' behaviour in the United Kingdom, Canada, the Netherlands, France, Germany and Sweden. These countries were selected because they represent the developed countries with different accounting systems. Furthermore, they are also the board member countries of IASC and OECD. 'Transparency' relating …

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Building Dss Using Knowledge Discovery In Database Applied To Admission & Registration Functions, Ahmed Abdel Hameed Hassan El-Ragal Jan 2001

Building Dss Using Knowledge Discovery In Database Applied To Admission & Registration Functions, Ahmed Abdel Hameed Hassan El-Ragal

Plymouth Business School Theses

This research investigates the practical issues surrounding the development and implementation of Decision Support Systems (DSS). The research describes the traditional development approaches analyzing their drawbacks and introduces a new DSS development methodology. The proposed DSS methodology is based upon four modules; needs' analysis, data warehouse (DW), knowledge discovery in database (KDD), and a DSS module. The proposed DSS methodology is applied to and evaluated using the admission and registration functions in Egyptian Universities. The research investigates the organizational requirements that are required to underpin these functions in Egyptian Universities. These requirements have been identified following an in-depth survey of …

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Pharmacokinetic And Pharmcodynamic Studies Of Apomorphine In The Treatment Of Idiopathic Parkinson's Disease, Wendy Ingram Jan 2001

Pharmacokinetic And Pharmcodynamic Studies Of Apomorphine In The Treatment Of Idiopathic Parkinson's Disease, Wendy Ingram

Peninsula Medical School Theses

There were two aspects to the study of apomorphine in the treatment of Parkinson' s disease: (i) a clinical pharmacokinetic-pharmacodynamic (PK-PD) study was designed and implemented in response to the challenges of apomorphine dose-titration in Parkinson's disease, and in view of the scarcity of available literature on the PK-PD relationships of apomorphine in Parkinson's disease, (ii) the PK(and tolerability)of apomorphine dosing using novel delivery/formulation combinations were explored in view of the inherent limitations associated with the conventional (ie. subcutaneous) route of administration of apomorphine (e.g. cutaneous nodule formation, needle-phobia). An HPLC assay was developed for the quantification of apomorphine in …

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Introducing Integrated Performance Measurement Into Small And Medium Sized Enterprises, Melanie Hudson Jan 2001

Introducing Integrated Performance Measurement Into Small And Medium Sized Enterprises, Melanie Hudson

Plymouth Business School Theses

The thesis extends current knowledge and understanding of integrated performance measurement (PM) development into the context of small and medium sized enterprises (SMEs). The research builds on existing knowledge of integrated PM development approaches and identifies the context-specific factors which affect its introduction into SMEs. These are used to design, develop and validate a new, continuous improvement based approach for the development of integrated PM systems, which is specifically designed for use in SMEs. First, a conceptual model of criteria for integrated PM development is synthesised from the literature and the characteristics of SMEs are established. An evaluation of current …

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The Quality Of Work Life: An Empirical Study, Tarek Hassan Ibrahim Abdeen Jan 2001

The Quality Of Work Life: An Empirical Study, Tarek Hassan Ibrahim Abdeen

Plymouth Business School Theses

This research examines the quality of work life in a selection of pharmaceutical companies in Egypt. It aims to test the relationships between the employees' perceptions of their quality of work life and; their perceptions of the degree of participation in decisionmaking available to them, their perceptions of their level of job satisfaction, their perceptions of their level of affective, continuance, and normative commitment, and the ownership form of the company. It uses a sample of 1270 employees in three different ownership forms; public, private, and multinational pharmaceutical companies in Egypt. The total sample size is proportionately distributed (i. e. …

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Team Player Styles, Team Design Variables And Team Work Effectiveness In Egypt, Ghada Awed Hassan El-Kot Jan 2001

Team Player Styles, Team Design Variables And Team Work Effectiveness In Egypt, Ghada Awed Hassan El-Kot

Plymouth Business School Theses

The literature has revealed few studies of management in Arab countries in general and particularly in Egypt. Many Egyptian organisations implemented the team concept a number of years ago, however, there do not appear to be any studies investigating team work effectiveness in Egypt. The literature review and the findings of a pilot study emphasised the need for empirical research in team work in Egypt. Team effectiveness models are examined in order to identify the factors that may enhance team effectiveness in Egypt. Team behavioural models are also examined to identify the importance of balanced team membership and its relationship …

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