Digital Commons Network^™

Physical Therapy Rehabilitation In A Patient With Guillain-Barre Syndrome With Acute Respiratory Failure: A Case Report, Daniel P. Torok

Physical Therapy Scholarly Projects

Background and Purpose. Guillain-Barre Syndrome (GBS) is a lower motor neuron autoimmune disorder that primarily affects the myelin sheaths of the peripheral nervous system (PNS). GBS results in generalized weakness and sensory deficits of the extremities and trunk; in severe cases it may impact cranial nerves, respiratory musculature, and the autonomic nervous system (ANS). The purpose of this case study is to describe the physical therapy interventions used for a patient diagnosed with GBS and the results from those interventions.

Case Description. This case study describes the 9-week acute care Physical Therapy management of a 51-year-old transgender female diagnosed with …

Characteristics And Spatial Heterogeneity Of Prescribed Fire Behavior In North Dakota Grasslands, Megan Elizabeth Zopfi

Theses and Dissertations

Fire is a critical physical and chemical process required to sustain many grassland ecosystems. In North America, observations of grassland fire behavior in warm-season, southern grasslands are commonly used in fire behavior modeling efforts across the Great Plains. However, grasslands of the northern Great Plains contain a greater component of cool-season vegetation that may generate different fire behavior. To further our understanding of prescribed fire behavior in North Dakota grasslands, we quantified fuel, weather, and fire behavior characteristics associated with 27 prescribed fires conducted across three sites in North Dakota. We sampled 27 points on each fire arranged into a …

An Examination Of The Use Of Corticosteroids For Adverse Effects Related To Immunotherapy Treatment In Cancer Patients, Leanne Kilzer

Nursing Capstones

No abstract provided.

Low-Dose Naltrexone For Treatment In Crohn’S Disease And Fibromyalgia, Hannah Rachel Tkach

Physician Assistant Scholarly Project Papers

The United States has experienced a dramatic increase in opioid abuse and overdoses, leading to a national epidemic. Contributing to this epidemic is the use of opioid therapy for complex chronic inflammatory and neuropathic conditions that remain difficult to treat. Many traditional treatments are ineffective or have intolerable side effects, forcing providers to utilize opioid therapy as a last resort. Recently, there is increased interest in the use of partial opioid antagonist naltrexone to treat Crohn’s disease and fibromyalgia. Previous research suggests the potential for naltrexone to provide analgesic effects when administered in low doses via its unique interaction with …

May 7, 2020: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the May 7, 2020, meeting of the University Senate. 106 pages

A Murine Model Of Lyme Disease Demonstrates That Borrelia Burgdorferi Colonizes The Dura Mater And Induces Inflammation In The Central Nervous System, Timothy Casselli, Ali Divan, Yvonne Tourand, Heidi L. Pecoraro, Catherine A. Brissette

Biomedical Sciences Faculty Publications

Lyme disease, which is caused by infection with Borrelia burgdorferi and related species, can lead to inflammatory pathologies affecting the joints, heart, and nervous systems including the central nervous system (CNS). Inbred laboratory mice are effective models for characterizing B. burgdorferi infection kinetics and host immune responses in joints and heart tissues; however, similar studies are lacking in the CNS of these animals. Here we characterize the kinetics of B. burgdorferi colonization and associated immune responses in the CNS of infected C3H mice during early and subacute infection. B. burgdorferi colonized the dura mater following needle or tick challenge, and …

Spring 2020, University Of North Dakota Alumni Association

ALL: UND Alumni Review Master List

Summer 2020 issue of "The University of North Dakota Alumni Magazine." 52 pages

Volume 103, Number 2

Deep Multilayer Brain Proteomics Identifies Molecular Networks In Alzheimer's Disease Progression, Bing Bai, Xusheng Wang, Yuxin Li, Ping-Chung Chen, Kaiwen Yu, Kaushik Kumar Dey, Jay M. Yarbro, Xian Han, Brianna M. Lutz, Shuquan Rao, Yun Jiao, Jeffrey M. Sifford, Jonghee Han, Minghui Wang, Haiyan Tan, Timothy I. Shaw, Ji-Hoon Cho, Suiping Zhou, Hong Wang, Mingming Niu, Ariana Mancieri, Kaitlynn A. Messler, Xiaojun Sun, Zhiping Wu, Vishwajeeth Pagala, Anthony A. High, Wenjian Bi, Hui Zhang, Hongbo Chi, Vahram Haroutunian, Bin Zhang, Thomas G. Beach, Gang Yu, Junmin Peng

Biology Faculty Publications

Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two independent cohorts, showing partial RNA dependency. Comparisons of brain tissue and cerebrospinal fluid proteomes reveal biomarker candidates. Combining with 5xFAD mouse analysis, we determine 15 Aβ-correlated proteins (e.g., MDK, NTN1, SMOC1, SLIT2, and HTRA1). 5xFAD shows a proteomic signature similar to symptomatic AD but exhibits activation of autophagy and interferon response and lacks human-specific deleterious events, …

Evidence And Rationale For Expanding The Views Of Nature Of Science Questionnaire, Ryan Summers, Fouad Abd-El-Khalick, Jeanne Brunner

Teaching, Leadership & Professional Practice Faculty Publications

In an attempt to understand nature of science (NOS) conceptions held by learners in greater detail, researchers have steadily become more reliant on open-ended measures. The Views of Science Questionnaire (VNOS) is the most frequently used open-ended instrument. Conceptually grounded in many of the same aspects emphasized in the Next Generation Science Standards, the VNOS-C is appropriate for capturing the views of secondary school students and adults along 10 dimensions related to NOS. However, it has been observed that the 10-item VNOS-C seems to have difficulty uncovering some particular NOS aspects, or rather respondents may need additional prompting. Two new …

Emotional Responses To A Sexual Assault Threat: A Qualitative Analysis Among Women With Histories Of Sexual Victimization, Kristin E. Silver, Raeann E. Anderson, Amanda M. Brouwer

Psychology Faculty Publications

Sexual assaults against women are a leading threat to human rights and public health in the United States. Considering the high rates of sexual revictimization among women and the limited understanding of the mechanisms which fuel this phenomenon, the goal of the present study was to investigate the role of emotion in coping with a hypothetical threat of sexual assault for previously sexually victimized college women. A total of 114 college women with a history of sexual victimization listened to an audio-recording describing a sexual assault scenario and then described how they felt. A qualitative analysis paradigm was used to …

Volume 57, Number 26: February 19, 2020, University Of North Dakota

University Letter Archive

No abstract provided.

Temporal Trends In The Standing Broad Jump Performance Of United States Children And Adolescents, Bridget K. Pinoniemi, Grant R. Tomkinson, Tanis J. Walch, James N. Roemmich, John S. Fitzgerald

Education, Health & Behavior Studies Faculty Publications

Purpose: To estimate temporal trends in broad jump performance for United States youth, a marker of muscular fitness and health.

Method: Electronic databases, topical systematic reviews, and personal libraries were systematically searched for studies reporting descriptive standing broad jump data for apparently healthy United States youth (age 10–17 years). Temporal trends at the sex-age level were estimated using sample-weighted regression models associating the year of testing to mean jump performance, with national trends standardized to the year 1985 using a post-stratified population-weighting procedure.

Results: Collectively, there was a small increase of 12.6 cm (95%CI: 12.5 to 12.7) or 7.9% (95%CI: …

A Systematic Analysis Of Temporal Trends In The Handgrip Strength Of 2,216,320 Children And Adolescents Between 1967 And 2017, Faith L. Dooley, Tori Kaster, John S. Fitzgerald, Tanis J. Walch, Madison Annandale, Katia Ferrar, Justin J. Lang, Jordan J. Smith, Grant R. Tomkinson

Education, Health & Behavior Studies Faculty Publications

Objective: To estimate national and international temporal trends in handgrip strength for children and adolescents, and to examine relationships between trends in handgrip strength and trends in health-related and sociodemographic indicators.

Methods: Data were obtained through a systematic search of studies reporting temporal trends in the handgrip strength for apparently healthy 9–17 year-olds, and by examining large national fitness datasets. Temporal trends at the country-sex-age level were estimated by sample-weighted regression models relating the year of testing to mean handgrip strength. International and national trends were estimated by a post-stratified population-weighting procedure. Pearson’s correlations quantified relationships between trends in handgrip …

Und Today: February 2020, University Of North Dakota

UND Today Archive

No abstract provided.

Role Of Endolysosomes And Inter-Organellar Signaling In Brain Disease, Zahra Afghah, Xuesong Chen, Jonathan David Geiger

Biomedical Sciences Faculty Publications

Endosomes and lysosomes (endolysosomes) are membrane bounded organelles that play a key role in cell survival and cell death. These acidic intracellular organelles are the principal sites for intracellular hydrolytic activity required for the maintenance of cellular homeostasis. Endolysosomes are involved in the degradation of plasma membrane components, extracellular macromolecules as well as intracellular macromolecules and cellular fragments. Understanding the physiological significance and pathological relevance of endolysosomes is now complicated by relatively recent findings of physical and functional interactions between endolysosomes with other intracellular organelles including endoplasmic reticulum, mitochondria, plasma membranes, and peroxisomes. Indeed, evidence clearly indicates that endolysosome dysfunction …

Treatment Of Clostridioides Difficile With Fecal Microbiota Transplantation, Brenton Green

Physician Assistant Scholarly Project Posters

Research was performed to discuss the epidemiology and current guidelines of Clostridioides difficile infection (CDI), recurrent C. difficile infection (rCDI), the different modalities of fecal microbiota transplantation (FMT), the donor screening process, as well as the safety and efficacy of treatment.

• Utilizing Clinical Key, NCBI database, Dynamed Plus, Cochrane Review, and the websites for the CDC and FDA, a literature review encompassing recent research and human studies relating to CDI.

• Recent studies within five years were preferred, however since C. difficile has sparsely changed, older data was utilized with updates applied accordingly.

• Oral antibiotics are intended for …

Effectiveness Of Complete Decongestive Therapy (Cdt) As A Lifestyle Management Intervention For Adults With Secondary Lymphedema., Hannah Curlett, Alexia Gallagher, Amy Shaver

Critically Appraised Topics

The National Cancer Institute (2019) explains that lymphedema is a condition where there is a buildup of fluid in soft tissues as a result of the lymphatic system being damaged or blocked. Lymphedema is estimated to impact 2 to 3 million people in the United States, with secondary lymphedema being the most common form (Rockson & Rivera, 2008). Prevalence rates for lymphedema are likely underestimated, as not all patients have received treatment for their condition (Rockson & Rivera, 2008). Secondary lymphedema occurs when the lymph system is damaged or blocked from cancer, infection, injury, removal of lymph nodes, radiation, or …

Critically Appraised Topic: Evidence For The Effectiveness Of Implementing Home Modifications To Age In Place, Feyi Adewoye, Michaela Gerving, Ashley Osbjornson

Critically Appraised Topics

Older adults are at an increased risk of falling due to several factors. This is an important topic for occupational therapy practitioners. The purpose of the CAT is to provide evidence to build occupation-based interventions such as home modifications that support the improvement of community-dwelling older adults’ quality of life through engagement in activities of daily living.

The Effect Of Proton Pump Inhibitors On Normal Gastrointestinal Flora Leading To Weight Change, Emi L. Binstock

Physician Assistant Scholarly Project Posters

The goal of this literature review was to determine what effects proton pump inhibitors (PPIs) have on the normal gastrointestinal (GI) flora and how that may lead to weight loss or weight gain. A literature search was performed using the database PubMed. Only articles from the last ten years (2009-2019) were included in this review. Keywords used in the search are listed below. After exclusion criteria was applied, 30 articles were relevant and used in this review. Five themes were identified in the literature review. An investigation of normal GI flora associated with weight loss and weight gain identified a …

An Analysis Of The Incidence And Severity Of Drug-Drug Interactions Between Prescribed Pharmaceuticals And Cannabinoids, Jennifer Mcrae

Physician Assistant Scholarly Project Posters

Identify the incidence and severity of drug-drug interactions between commonly prescribed medications and cannabinoids • Medications that are substrates for CYP2C19, CYP2C9 and CYP1A2 are at the greatest risk of interaction with concomitant use of phytocannabinoids or synthetic cannabinoids • Caution is recommended with medications metabolized via UGT or CES1, however information is currently limited and further research is necessary • Lack of universal standards for laboratory testing of cannabinoid products call into question the legitimacy of reported results in currently reported research as the contents of many cannabinoid products are inaccurately labeled

Sixty Years Of Boom And Bust: The Impact Of Oil In North Dakota, 1958-2018, Kyle Conway

Digital Press Books

In the 1950s, North Dakota experienced its first oil boom in the Williston Basin, on the western side of the state. The region experienced unprecedented social and economic changes, which were carefully documented in a 1958 report by four researchers at the University of North Dakota. Since then, western North Dakota has undergone two more booms, the most recent from 2008 to 2014. Sixty Years of Boom and Bust republishes the 1958 report and updates its analysis by describing the impact of the latest boom on the region’s physical geography, politics, economics, and social structure.

Sixty Years of Boom and …

Aging In Place: Causes And Importance Of Fall Prevention Education, Molly Banks, Danielle Halstead, Mariah Leroux

Critically Appraised Topics

Falls are a significant concern for older community-dwelling adults’ ability to age in place, specifically those who aged 60 and older. Many factors contribute to the risk of falls in older adults that need to be addressed by health care facilities, home health providers, and caretakers. Occupational therapy has a role to educate older adults, as well as health care providers on how to prevent the risk factors of older adults and falls. The purpose of this CAT is to take a deeper look at why this population has so many falls and examine the research addressing education and risk …

Winter 2020, University Of North Dakota Alumni Association

ALL: UND Alumni Review Master List

Winter 2020 issue of "The University of North Dakota Alumni Magazine." 52 pages

Volume 103, Number 4

How To Be An Advocate: Summary Of “Realizing Abct’S Mission In A Politicized World” Presented By Lynn Bufka, Anita Brown, Brandon Gaudiano, Megan Gordan-Kane, Lauren Macivor Thompson, And Laura Seligman, Raeann E. Anderson, Erica L. Goodman, Danielle Piggott, Sidney Thimm, Kristin E. Silver, Paige Michel

Psychology Faculty Publications

No abstract provided.

An Investigation Of Loss Of Control Eating Episodes And The Five Indicator Variables Of Loss Of Control Eating In A Non-Clinical Sample, Erica Goodman

Theses and Dissertations

Binge eating is common across both clinical and non-clinical populations; the diagnostic definition of binge eating has been scrutinized by extant literature in that findings have shown loss of control (LOC) to be more related to pathology than the amount of food consumed. The current study aimed to elucidate this notion further by investigating different types of LOC eating based on perception and amount of food consumed. College students (N = 227) completed self-report questionnaires assessing disordered eating, psychopathology, emotion regulation, impulsivity, quality of life, and self-esteem; 173 (76%) also completed an interview on typical and LOC eating in the …

The Value Of Existential Worlds: Creation And Validation Of A Measure To Explore The Four Existential Worlds, Matthew Robert Rozzi

Theses and Dissertations

The field of counseling psychology is increasingly focused on understanding clients in holistic and non-pathologizing ways. Existential theory provides the four-worlds model for exploring human existence in line with this modern psychological zeitgeist. In this model, humans are understood to exist simultaneously in four “worlds” or “dimensions”: physical (umwelt), social (mitwelt), psychological (eigenwelt), and spiritual/philosophical (uberwelt). This measure construction project is the first known study to examine the personal importance (value) of existing in each world. The Value of Existential Worlds (VEW) was created and psychometrically examined. From the initial 63-items, a shorter (20-item) version was created which demonstrated a …

Examining College Students’ Emotions And Alcohol Usage On A College Campus: Student Chemical Assessment And Review Program (Scarp), Thomas William Solem

Theses and Dissertations

Alcohol use and abuse is an important issue amongst college students, and the totality of impacts are still misunderstood. Identification of high-risk alcohol abuse problems leads universities to intervene; however, the emotional, personal, and academic impacts of such mandated intervention programs is unclear. Helping universities understand students’ alcohol abuse challenges can aid appropriate interventions, as well as improve student well-being and academic success.

The purpose of this study is to examine the Student Chemical Assessment Review Program (SCARP), specifically to explore its impacts on student variables (university motivation, readiness/importance of confidence to change, self-esteem, guilt, shame, depression, anxiety, and resiliency) …

Investigation Of The Neurological Manifestations Of Lyme Disease And The Impact Of Borrelia Burgdorferi On The Epigenetic Landscape Of Astrocytes, Derick Thompson

Theses and Dissertations

Lyme disease, caused by the spirochete Borrelia burgdorferi (Bb), is the most commonly reported vector-borne disease in the United States – with 30,000 cases being reported to the CDC annually, though it is estimated that 300,000 individuals are infected each year in the U.S [1–4]. Due to the medical treatment of the disease, this equates to an estimated $712 million - $1.3 billion in medical costs each year [5]. Conclusively, due to the continued geographical spread and increasing incidence rate, Lyme disease is becoming a greater public health threat throughout the world.

The symptoms of Lyme disease can range from …

A Systematic Analysis Of Temporal Trends In Handgrip Strength For 2,584,978 Adults Between 1960 And 2017, Trevor James Dufner

Theses and Dissertations

Purpose: To systematically analyze temporal trends in handgrip strength (HGS) for adults.

Methods: Four electronic databases, along with researcher’s personal libraries, were searched up to August 2019 for studies reporting on temporal trends in mean HGS for apparently healthy adults who were broadly representative of their source population. Temporal trends in mean HGS were analyzed at the country-sex-age group level using sample-weighted linear or polynomial (quadratic or cubic) regression models.

Results: Data from eight studies/datasets were extracted to estimate trends in mean HGS for 2,584,978 adults aged 20–90+ years from 13 different countries (across three continents) between 1960 and 2017. …

Twice-Exceptional College Students Narratives: When Giftedness And Mental Health Intersect, Emily Dubord Hill

Theses and Dissertations

Gifted college students often arrive at universities with high GPAs and/or ACT/SAT scores. Their achievements in extracurricular activities such as in the arts, athletics, service, and leadership are well beyond the average student. To admissions representatives and faculty, these students look well-adjusted and successful on paper. However, many of these gifted college students come with unique challenges that go misunderstood, ignored, and underserved during their years in higher education—specifically involving their mental health.

There are copious amounts of literature on gifted K-12 students and their mental health behaviors but very limited research done on the gifted college student population. Although …