Digital Commons Network^™

Volume 53, Number 52: August 10, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

App Regulates Microglial Phenotype In A Mouse Model Of Alzheimer's Disease, Gunjan D. Manocha, Angela M. Floden, Keiko Rausch, Joshua A. Kulas, Brett A. Mcgregor, Lalida Rojanathammanee, Kelley R. Puig, Kendra L. Puig, Sanjib Karki, Michael R. Nichols, Diane C. Darland, James E. Porter, Colin K. Combs

Biology Faculty Publications

Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia. Therefore, we hypothesized that APP serves this function in microglia during Alzheimer's disease. Although fibrillar amyloid β (Aβ)-stimulated cytokine secretion from both wild-type and APP knock-out (mAPP−/−) microglial cultures, oligomeric Aβ was unable to stimulate increased secretion from mAPP−/− cells. This was consistent with an ability of oligomeric Aβ to bind APP. Similarly, intracerebroventricular infusions of oligomeric Aβ produced less microgliosis in mAPP−/− mice compared with wild-type mice. The mAPP−/− mice crossed to an APP/PS1 transgenic mouse line …

Summer Commencement: August 5, 2016, University Of North Dakota

UND Commencement Programs

UND Summer Commencement program from August 5, 2016.

Volume 53, Number 51: August 03, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Physiological Perturbation Reveals Modularity Of Eyespot Development In The Painted Lady Butterfly, Vanessa Cardui, Heidi Connahs, Turk Rhen, Rebecca Simmons

Biology Faculty Publications

Butterfly eyespots are complex morphological traits that can vary in size, shape and color composition even on the same wing surface. Homology among eyespots suggests they share a common developmental basis and function as an integrated unit in response to selection. Despite strong evidence of genetic integration, eyespots can also exhibit modularity or plasticity, indicating an underlying flexibility in pattern development. The extent to which particular eyespots or eyespot color elements exhibit modularity or integration is poorly understood, particularly following exposure to novel conditions. We used perturbation experiments to explore phenotypic correlations among different eyespots and their color elements on …

Volume 53, Number 50: July 27, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Strategies For Optimizing Online Learning In Nursing Staff Education, Jodi Edlund

Nursing Capstones

No abstract provided.

Volume 53, Number 47: July 06, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Vol. 41, No. 2: Summer 2016, School Of Medicine & Health Sciences

North Dakota Medicine Archive

No abstract provided.

Independent Study Project: The Use Of Exercise In Treating Depression, Katelin Umland

Nursing Capstones

No abstract provided.

Volume 53, Number 45: June 22, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Management Of The Pediatric Patient With Emergence Agitation, Jessica Mcdonnell

Nursing Capstones

No abstract provided.

Volume 53, Number 44: June 15, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Digital Fragment Analysis Of Short Tandem Repeats By High‐Throughput Amplicon Sequencing, Brian J. Darby, Shay F. Erickson, Samuel D. Hervey, Susan N. Ellis-Felege

Biology Faculty Publications

High‐throughput sequencing has been proposed as a method to genotype microsatellites and overcome the four main technical drawbacks of capillary electrophoresis: amplification artifacts, imprecise sizing, length homoplasy, and limited multiplex capability. The objective of this project was to test a high‐throughput amplicon sequencing approach to fragment analysis of short tandem repeats and characterize its advantages and disadvantages against traditional capillary electrophoresis. We amplified and sequenced 12 muskrat microsatellite loci from 180 muskrat specimens and analyzed the sequencing data for precision of allele calling, propensity for amplification or sequencing artifacts, and for evidence of length homoplasy. Of the 294 total alleles, …

Longitudinal Effects Of Embryonic Exposure To Cocaine On Morphology, Cardiovascular Physiology, And Behavior In Zebrafish, Eric J. Mersereau, Cody A. Boyle, Shelby Poitra, Ana Espinoza, Joclyn Seiler, Robert Longie, Lisa Delvo, Megan Szarkowski, Joshua Maliske, Sarah Chalmers, Tristan Darland, Diane Darland

Biology Faculty Publications

A sizeable portion of the societal drain from cocaine abuse results from the complications of in utero drug exposure. Because of challenges in using humans and mammalian model organisms as test subjects, much debate remains about the impact of in utero cocaine exposure. Zebrafish offer a number of advantages as a model in longitudinal toxicology studies and are quite sensitive physiologically and behaviorally to cocaine. In this study, we have used zebrafish to model the effects of embryonic pre-exposure to cocaine on development and on subsequent cardiovascular physiology and cocaine-induced conditioned place preference (CPP) in longitudinal adults. Larval fish showed …

Time Changes In The Body Dimensions Of Male Australian Army Personnel Between 1977 And 2012, Grant Tomkinson, Nathan Daniell, Ashley Fulton, Alistair Furnell

Education, Health & Behavior Studies Faculty Publications

The aim of this study was to quantify time changes in the body dimensions of male Australian Army personnel. Following a systematic review, two studies were identified and matched for occupation and age (n = 669) with time changes in 12 absolute and 11 proportional body dimensions assessed between 1977 and 2010–12. Changes in means were expressed as absolute, percent and standardised changes, with changes in variability assessed visually and as the ratio of coefficients of variation (CVs). Time changes in absolute dimensions were typically positive (increases) and moderate in magnitude (median standardised change ± 95%CI: 0.53 ± 0.23), …

Volume 53, Number 41: May 25, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Ontology-Based Collection, Representation And Analysis Of Drug-Associated Neuropathy Adverse Events, Abra Guo, Rebecca Racz, Junguk Hur, Yu Lin, Zuoshuang Xiang, Jordan Rinder, Guoqian Jiang, Qian Zhu, Yongqun He

Biomedical Sciences Faculty Publications

Background: Neuropathy often occurs following drug treatment such as chemotherapy. Severe instances of neuropathy can result in cessation of life-saving chemotherapy treatment.

Results: To support data representation and analysis of drug-associated neuropathy adverse events (AEs), we developed the Ontology of Drug Neuropathy Adverse Events (ODNAE). ODNAE extends the Ontology of Adverse Events (OAE). Our combinatorial approach identified 215 US FDA-licensed small molecule drugs that induce signs and symptoms of various types of neuropathy. ODNAE imports related drugs from the Drug Ontology (DrON) with their chemical ingredients defined in ChEBI. ODNAE includes 139 drug mechanisms of action from NDF-RT and 186 …

International Normative 20 M Shuttle Run Values From 1 142 026 Children And Youth Representing 50 Countries, Grant Tomkinson, Justin J. Lang, Mark S. Tremblay, Michael Dale, Allana G. Leblanc, Kevin Belanger, Francisco B. Ortega, Luc Léger

Education, Health & Behavior Studies Faculty Publications

Objective To develop sex-specific and age-specific international norms for the 20 m shuttle run test (20mSRT) in children and youth (aged 9–17 years), and to estimate the prevalence meeting the FITNESSGRAM criterion-referenced standards for healthy cardiorespiratory endurance (CRE).

Methods A systematic review was undertaken to identify papers explicitly reporting descriptive 20mSRT (with 1 min stages) data on children and youth since 1981. Data were included on apparently healthy (free from known disease/injury) 9–17 years old. Following standardisation to a common metric and for protocol differences, pseudo data were generated using Monte Carlo simulation, with population-weighted sex-specific and age-specific normative centiles …

Volume 53, Number 40: May 18, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Doctor Of Medicine Commencement: May 15, 2016, University Of North Dakota

UND Commencement Programs

Doctor of Medicine Commencement program from May 15, 2016.

Spring Commencement: May 14, 2016, University Of North Dakota

UND Commencement Programs

UND Spring Commencement program from May 14, 2016.

Volume 53, Number 39: May 11, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Management Of Hypertension In African Americans As Compared To Non-African Americas, Jamie C. Hanrahan

Nursing Capstones

No abstract provided.

Volume 53, Number 38: May 04, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Protective Effects Of Oral Contraceptives On Ovarian Cancer, Megan Retterath

Nursing Capstones

No abstract provided.

Species-Recognition Program: A Computer-Assisted Approach To Recognizing Species, Steve Kelsch, Jeffrey Carmichael

Biology Faculty Publications

Species recognition is a crucial component for many types of biological studies. To that end, broadly trained students must be able to accurately identify many different types of organisms. Courses that focus on learning the names of different species traditionally rely on preserved specimens viewed during class or laboratory time. Unfortunately, reliance on preserved specimens comes with many challenges in providing students with an optimal learning experience. The curriculum activity described here uses a modified PowerPoint file (species-recognition program—SRP) as a means of helping students learn to recognize and identify fishes based on subtle visual cues. Our results indicate that …

Towards The Enhancement Of A Critical Cultural Paradigm In Health Communication: An Examination Of The Impact Of Paradigmatic Structures, Laura Elizabeth Arneson

Theses and Dissertations

In the field of Communication there are a wide variety of ways in which scholars can utilize theories to serve as epistemological frameworks in order to examine sociological structures. In this thesis, the subfield of Health Communication will be examined through a positivistic and critical cultural studies paradigm. This work will then examine underlying assumptions related to theoretical approaches in health communication.

With the primary argument of this work being that the dominant approaches in Healthcare Communication have been primarily rooted in positivism, this research study will attempt to show how this assumption continues to extend even into new digital …

April 29, 2016, The Dakota Student

The Dakota Student

No abstract provided.

Volume 53, Number 37: April 27, 2016, University Of North Dakota

University Letter Archive

No abstract provided.