Digital Commons Network^™

Inorganic Arsenite [I-As (Iii)] Represses Human Renal Progenitor Cell Characteristics And Induces Neoplastic-Like Transformation, Md Ehsanul Haque

Theses and Dissertations

Studies on populations exposed to inorganic arsenic (iAs) have shown an association between this particular exposure and the development of chronic kidney disease (CKD) and renal cell carcinoma (RCC). However, there are few studies addressing how acute exposure of the human kidney to iAs might lead to long-term alterations that might lead to CKD or RCC. This study’s hypothesis is that renal exposure to iAs might alter the renal cells responsible for the repair and regeneration of nephrons damaged by iAs exposure or other renal toxicants. The kidney possesses a minority epithelial cell population that co-express PROM1 and CD24 that …

Evaluation Of Schlafen Family Proteins In Triple Negative Breast Cancer, Savannah Brown

Theses and Dissertations

This dissertation explores the role of Schlafen (SLFN) family proteins in Triple-Negative Breast Cancer (TNBC), a subtype known for its aggressive behavior and poor response to treatment. Through a series of studies, this dissertation examines the interplay between multiple SLFN proteins, chemotherapy resistance, and immune modulation, revealing the potential of SLFN12 as both a biomarker and therapeutic target for improving treatment outcomes, particularly in overcoming chemoresistance in TNBC.

Breast cancer, the most common cancer worldwide, includes various subtypes like TNBC, which lacks estrogen, progesterone, and HER2 receptors, making it resistant to conventional therapies. SLFN proteins, first discovered in mice, regulate …

Cisplatin-Induced Nephrotoxicity And Adaptive Responses In Renal Progenitor Cells: Molecular Insights From Transcriptomic And Proteomic Analyses, Eloho Ighofose

Theses and Dissertations

Cisplatin is a widely used chemotherapeutic agent known for its efficacy against various solid tumors, but its clinical utility is limited by dose-dependent nephrotoxicity. The renal proximal tubule, particularly its epithelial cell population, is highly susceptible to cisplatin-induced injury due to its role in solute transport and high metabolic activity. Recent advances suggest that renal progenitor cells play a key role in epithelial repair following nephrotoxic injury; however, the molecular mechanisms underlying their response to cisplatin remain poorly understood.This study investigates the impact of both acute and chronic cisplatin exposure on immortalized human renal progenitor cells (HRTPT, CD24⁺/CD133⁺) using a …

Airflow Over Nasa’S X-59, Quiet Supersonic Technology (Quesst), Laina Behrenbrinker, Carson Running

Mechanical Engineering Student Publications

The X-59 QueSST is an experimental aircraft that will reach supersonic speeds without producing a loud sonic boom. Those on the ground will hear something like distant thunder as the X-59 passes overhead, around 75 dB. This paper studies the pressure distribution over the nose of the X-59 and the Sound Pressure Level (SPL) on the surface of the X-59 nose (1/3 of the total vehicle length) to better understand how sound propagates through the atmosphere. The resulting SPL over the aircraft nose is 180 – 190 dB, and further the SPL on the ground is calculated to be 43-53 …

The Effects Wind Has On Ocean Current Speeds For Marine Renewable Energy Applications, Parkerjay Hoaglund, Carson Running

Mechanical Engineering Student Publications

This paper explores the influence of wind on ocean current speeds at varying depths and its implications for marine renewable energy systems, particularly underwater turbines. By analyzing the fluid mechanics of ocean currents and applying the Navier-Stokes equations under simplified assumptions, velocity and pressure profiles were developed to model the interaction between wind and water. The research highlights the dependence of ocean current velocity on wind speed and depth, demonstrating that maximum current speeds and power generation potential occur near the ocean surface. Using MATLAB simulations, power generation by an underwater turbine was analyzed under varying wind speeds and depths, …

Effects Of Pollution On The Flow Of The Gowanus Canal, Eleanore Dzija, Carson Running

Mechanical Engineering Student Publications

This paper explores how pollution affects the flow of the Gowanus Canal. Four scenarios are modeled to represent different phases of pollution remediation: no remediation, dredging and capping of the canal bottom, combined sewer overflow capture, and dredging and capping with combined sewer overflow capture. Dredging and capping of the canal bottom resulted in the greatest increase in velocity. Dredging and capping with combined sewer overflow capture resulted in the greatest decrease in pressure. This indicates that dredging and capping of the canal bottom may be the most efficient pollution remediation strategy and should be the focus of the cleanup …

The Effect Of Temperature On Power Output From A Hydroelectric Penstock, Taylor Hartell, Carson Running

Mechanical Engineering Student Publications

Hydroelectric power is a form of renewable energy that uses the power from water to generate electricity. One of the ways this is done is by diverting water from a river with a penstock leading to a turbine. Hydroelectric systems rely on water as the source of power, and the viscosity of water varies with temperature. When temperatures are low, viscosity is high, and when temperatures are high, viscosity is low. Other works have studied the optimal dimensions of penstocks for power generation and the effect of hydroelectric power on river temperatures. In this research, the effect of temperature on …

Womens Labor Laws, Trinity Blair

History Hawks: A North Dakota History Zine

Women in the Progressive Era were often not protected by any laws. In 1919, North Dakota passed a law limiting women's work hours. Other states were enacting laws similar to the one in North Dakota.

Eminent Domain And The Displacement Of Nd Families: The Impact Of The Garrison Dam, Lauren Steeves

History Hawks: A North Dakota History Zine

This zine looks at the consequences of the United States government exercising the power of eminent domain, as seen in the 1953 United States of America vs. Certain Lands case.

The Grasshopper Outbreak Of The 1930s, Carsen Grave

History Hawks: A North Dakota History Zine

The Dust Bowl sparked a massive grasshopper outbreak in the 1930s, forcing many North Dakotans to flee. Those who remained endured hardship and persevered, ultimately finding relief in a wet spring in 1940.

Winter Commencement: December 20, 2024, University Of North Dakota

UND Commencement Programs

UND Winter Commencement program from December 20, 2024.

Critical Review Of Loneliness Rates Among Undergraduates, Emily Schmitz

Psychology Student Publications

This study assesses loneliness rates among undergraduates from fall 2008 to spring 2019 through a secondary analysis of the National College Health Assessment II (NCHA II). The NCHA II, a comprehensive and nationally representative survey, covers a wide range of mental and physical health issues among U.S. college students. The survey consisted of questions which had students self-identify if they have felt very lonely within the last 2 weeks, 30 days, and 12 months. The study revealed that 54.90% to 67.40% of undergraduate students reported feeling very lonely during these survey periods. The results showed that most undergraduates experienced loneliness, …

Science Communication: What Are The Psychological Effects Of Keeping Secrets?, Sydney Rygg

Psychology Student Publications

No abstract provided.

The Effects Of Animals On Our Mental Health, Gracie Bowles

Psychology Student Publications

I analyzed different published journals on how animals affect our mental health. I put it into less scientific terms and made it more fun with adding in personal experiences.

Do Political Views Really Affect Romantic Relationships?, Avery Durfee

Psychology Student Publications

This paper covers the effects of political view differences in a romantic setting. Some of the effects include the overall outlook of people with dissimilar views, the relationship quality, and the overall moral values held by those in the relationship. Through examination of scientific journals, it is clear that political views really do affect romantic relationships.

The Stressful Task Of Building Resilience, Zoey Swanson

Psychology Student Publications

No abstract provided.

Political Polarization Will Not Ruin Your Love Life, Olivia Schlosser

Psychology Student Publications

No abstract provided.

Contagious Infidelity, Rachel Markle

Psychology Student Publications

No abstract provided.

How Media Representation Influences Disability Bias, Emilie Brend

Psychology Student Publications

No abstract provided.

Scrolling Into Disorder: Social Media And Body Image, Anna Funk

Psychology Student Publications

No abstract provided.

Support For Gay Marriage In Italy And Spain: Public Perceptions In The Context Of Legalization, Dana Conley

Arts & Sciences Undergraduate Showcase

In this paper factors that contribute to support for gay marriage are examined in two countries, Italy and Spain. Diffusion theory was applied to explore this idea. This research seeks to explore whether the legalization of gay marriage has an impact on the level of support for gay marriage in that country. Furthermore, this research is important to determine what factors contribute to shaping support for gay marriage. From there it may also be possible to identify where prejudices against gay marriage might come from. Personal attitudes towards support for gay marriage can vary due to a variety of factors. …

Investigation Of Real-Time Gaseous Thermal Decomposition Products Of Representative Per- And Polyfluoroalkyl Substances (Pfas), Kateřina Litvanová, Bethany Klemetstrud, Feng Xiao, Alena Kubatova

Chemistry Faculty Publications

The thermal decomposition of per- and poly fluoroalkyl substances (PFAS) is poorly understood. Here, we present an innovative, comprehensive analytical method to investigate their thermal decomposition, including perfluorocarboxylic acids (PFCAs), alcohol, sulfonates, and GenX (acid dimer), focusing on identifying their breakdown products. In this study, evolved gas analysis–mass spectrometry (EGA-MS) was used for fast real-time screening to determine the significant temperatures to be investigated with the thermal desorption-pyrolysis coupled with gas chromatography–mass spectrometry (TD-Py-GC-MS), which provided detailed information about evolved PFAS and their breakdown products. This approach enabled a systematic study of perfluorocarboxylic acids (PFCAs) ranging from C₃ to …

Characterizing The Risk Of Meteorite Ejecta To Future Lunar Surface Operations, Jacob Yates

Theses and Dissertations

In-situ materials provided adequate shielding against the risk of meteorite ejecta for future lunar surface operations. Both regolith simulant and simulant-epoxy mixtures stopped simulated ejecta projectiles with velocities at or near lunar escape velocity. Those depth penetrations for those two in-situ related materials were shallow inside 3 cm and may prove to be influential in future mission planning of lunar surface operations. The lunar surface poses a potential risk from meteoroid ejecta for future lunar surface operations. The safety ramifications of long-term crewed missions for the Artemis program, NASA’s lunar program, are being investigated or reconsidered from the previous Apollo …

December 12, 2024, The Dakota Student

The Dakota Student

No abstract provided.

Preservation To Publisher: Flipping Textbooks Open Using The Und Scholarly Commons, Zeineb Yousif

Librarian Posters and Presentations

In 2017, the Chester Fritz Library launched our institutional repository, the UND Scholarly Commons. Our first publication was an open access edition of The History of North Dakota, a widely used state history book that we purchased the rights to publish digitally. After receiving scans of the print book from the publisher, we created PDF, EPUB, and MOBI versions of the book and disseminated it widely across OER indexing platforms.

We drew on this experience in 2023, when we partnered with North Dakota’s Department of Public Instruction to release digital editions of a series of textbooks about the culture and …

Understanding Ai Literacy: Implications For Practice, Sara Westall, Janet Anderson, Devon Olson

Librarian Publications

A presentation developed for the fall 2024 University of North Dakota School of Medicine and Health Sciences Medical Curriculum Advance, exploring the connections between information literacy, artificial intelligence literacy, and algorithmic literacy and their relevance to health education from the perspective of research and instruction librarians.

Spectrometric Detection Of Microplastics In The Environment: A Novel Approach Using Hyperspectral Imaging System, Mansurat Abdulmalik Ali

Theses and Dissertations

Microplastics (MPs), defined as plastic particles ranging from 1 μm to 5 mm, have emerged as one of the significant environmental contaminants due to their widespread presence in terrestrial and aquatic ecosystems. MPs originate from primary sources, such as industrial pre-production pellets and microbeads in personal care products, or secondary sources, such as the breakdown of larger plastic particles. Their persistence in the environment is due to their resistance to degradation and capacity to transport toxic substances and pathogens. These characteristics raise concerns about their ecological impacts and potential entry into food chains, ultimately affecting human health. Despite extensive research …

Applied Indigenous Knowledge Translation: Naatookyookaasii, Lynn Marie Mad Plume

Theses and Dissertations

This dissertation portfolio comprises three projects aimed at advancing Indigenous health and integrating cultural perspectives into research and practice. Guided by principles of community engagement and ethical research practices, these projects align closely with my career goals in Indigenous health policy and research. The first project, "Measuring Wellness Through Indigenous Partnerships," is a scoping review that examines global Indigenous wellness measures and assesses community involvement in defining measures of wellness. This review informs future practice directions and supports my advocacy for culturally responsive methodology. The second project, "Reciprocal Facilitation: Protocols and Practices for Listening Sessions with Tribal Communities," introduces a …

What Makes Social Media So Addictive, And How Does It Affect Our Mental Health?, Abigail Larson

Psychology Student Publications

This paper will dig into what makes social media so addicting, focusing on factors like dopamine release, instant gratification, habit formation, and the need for social validation, along with how these things negatively affect mental health.

Exploring The Potential Of Hybrid Wind-Solar Energy Systems For Residential Applications In North Dakota, Toluwase Testimony Omojiba

Theses and Dissertations

North Dakota's high residential energy consumption, driven by extreme weather, is largely met by fossil fuels, contributing significantly to CO₂ emissions. This study evaluates the technical performance, environmental benefits, and economic viability of hybrid wind-solar-energy systems for residential applications in the state.

Using HOMER modeling, two scenarios were analyzed: homes using a combination of utility gas and electricity, and homes relying solely on electricity. Simulations for Grand Forks, Bismarck, and Dickinson showed that hybrid systems reliably met residential energy demand, covering 100% of the annual load in the gas-electric scenario across all locations. In the all-electric scenario, systems achieved at …