Digital Commons Network^™

Elevated Tsh And Obesity: Cause Or Consequence?, Ashley Rose

Nursing Capstones

No abstract provided.

Risks And Benefits Of Administering Bisphosphonates With A Diagnosis Of Atypical Osteoporotic Fracture, Molly Beyer

Nursing Capstones

No abstract provided.

March 7, 2019: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the March 7, 2019, meeting of the University Senate. 49 pages

Nonpharmacologic Interventions And Lifestyle Modifications Resulting In Prevention And Reduction Of Osteoporosis, Alicia Crosby

Nursing Capstones

No abstract provided.

Seasonal Home Ranges And Habitat Selection Of Three Elk (Cervus Elaphus) Herds In North Dakota, Jacqueline C. Amor, Robert Newman, William F. Jensen, Bradley Rundquist, W. David Walter, Jason R. Boulanger

Biology Faculty Publications

Changes in land use have resulted in range shifts of many wildlife species, including those entering novel environments, resulting in the critical need to understand their spatial ecology to inform ecosystem effects and management decisions. Dispersing elk (Cervus elaphus) were colonizing areas of suitable habitat in the Northern Great Plains, USA, resulting in crop depredation complaints in these areas. Although state resource managers had little information on these elk herds, limited evidence suggested temporal movements into Canada. We collected and analyzed essential information on home range and habitat selection for 3 elk herds residing in North Dakota. We …

Intermittent Fasting In Weight Management, Alyse Engen

Physician Assistant Scholarly Project Papers

Obesity is associated with a variety of medical conditions that adversely affect metabolic and cardiovascular health. In order for health care providers to adequately educate and promote weight management, they need to be aware of the various dietary regimens and the efficacy and adverse effects associated with each. The purpose of this study is to analyze research assessing the efficacy and health benefit of intermittent energy restriction and compare to the efficacy and health benefits of continuous energy restriction. This literature review assesses the efficacy, metabolic benefits, and cardiovascular benefits of both intermittent energy restriction and continuous energy restriction from …

Parenteral Ascorbic Acid For Treatment Of Sepsis, Lindsey Hiatt

Physician Assistant Scholarly Project Papers

Sepsis kills nearly 1 million people each year in the United States and sepsis-related hospitalizations cost approximately $24 billion annually (Paoli, Reynolds, Sinha, Gitlin, & Crouser, 2018). Current treatment guidelines are limited to targeted antibiotics and hemodynamic support. While antibiotics are the definitive treatment to eradicate the infectious pathogen, there are currently no standard-of-care treatments that consistently and successfully attenuate the damage sustained to the body by its own inflammatory response to infection. Many different treatments have been trialed and failed to show improved outcomes. Vitamin C, or ascorbic acid, has long been associated with supporting immune function, and has …

Delaying Onset Of Diabetes In Native American Populatons, Seth Tramm

Physician Assistant Scholarly Project Papers

Diabetes is a debilitating disease process caused by the body’s inability to control blood glucose levels. With over 30 million diabetics in the United States, and another 85 million prediabetics, the effects of this disease are wide-spread and far-reaching. Native American/Alaska Native populations have a nearly two-fold increase in incidence of diabetes when compared to non-native populations. Risk factors for diabetes in all populations include modifiable risks such as obesity, diet, physical inactivity as well as non-modifiable factors such as age, family history, and ethnicity. Studies have shown that early identification of symptoms, coupled with proper and intentional treatment can …

Volume 56, Number 24: January 30, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

Simultaneous High-Temperature Gas Chromatography With Flame Ionization And Mass Spectrometric Analysis Of Monocarboxylic Acids And Acylglycerols In Biofuels And Biofuel Intermediate Products, Gana Flanagan, Anastasia A. Andrianova, Jana Casey, Eric Hellrung, Bonnie A. Diep, Wayne Seames, Alena Kubatova

Chemistry Faculty Publications

Triacyl-, diacyl- and monoacylglycerols (TAGs, DAGs, MAGs) along with monocarboxylic acids (MCAs) are intermediate products in many triacylglycerol oil-to-biofuel conversion pathways. Accumulation of these compounds leads to poor biofuel characteristics and may result in fuel system damage. We developed a method for simultaneous identification and quantification of a wide range of MCAs (C4-C18), MAGs, DAGs, and TAGs. The method is based on trimethylsilylation followed by high temperature GC with programmed temperature vaporizer (PTV) injection coupled to parallel FID and MS detectors (HTGC-FID/MS).

To minimize the discrimination of both low and high molecular weight species typically occurring on the injector, we …

Ca2+ Entry Via Trpc1 Is Essential For Cellular Differentiation And Modulates Secretion Via The Snare Complex, Thad A. Rosenberger, Anne Schaar, Yuygang Sun, Pramod Sukumaran, Danielle Krout, James N. Roemmich, Lutz Brinbaumer, Kate Claycombe-Larson, Brij B. Singh

Biomedical Sciences Faculty Publications

Adipocyte functionality, including adipocyte differentiation and adipokine secretion, is essential in obesity-associated metabolic syndrome. Here, we provide evidence that Ca2+ influx in primary adipocytes, especially upon store-depletion, plays an important role in adipocyte differentiation, functionality, and subsequently metabolic regulation. The endogenous Ca2+ entry channel in both subcutaneous and visceral adipocytes was dependent on TRPC1-STIM1 and blocking Ca2+ entry with SKF-96365 or TRPC1-/- derived adipocytes inhibited adipocyte differentiation. Additionally, TRPC1-/- mice have decreased organ weight, but increased adipose deposition and reduced serum adiponectin and leptin concentrations, without affecting total adipokine expression. Mechanistically, TRPC1- mediated Ca2+ entry regulated SNARE complex formation and …

Intermittent Fasting In Weight Management, Alyse Engen

Physician Assistant Scholarly Project Posters

Obesity is associated with a variety of medical conditions that adversely affect metabolic and cardiovascular health. In order for health care providers to adequately educate and promote weight management, they need to be aware of the various dietary regimens and the efficacy and adverse effects associated with each. This literature review assesses the efficacy, metabolic benefits, and cardiovascular benefits of both intermittent energy restriction and continuous energy restriction from ten articles found on various databases within the past five years. The findings indicate that although not proven superior or inferior, intermittent energy restriction provides statistically similar results to continuous energy …

A Case Report: Treatment Of Facioscapulohumeral Muscular Dystrophy, Jeremy Korthuis

Physical Therapy Scholarly Projects

Purpose: The purpose of the case study was to explain a treatment program involving low/moderate intensity strength training and stretching for a patient with facioscapulohumeral muscular dystrophy (FSHD).

Background: FSHD is the third most common type of muscular dystrophy. This pathology results from a mutation in chromosome 4 and results in progressive weakening of facial, scapular, and hip musculature. Research behind effective strengthening programs is often inconclusive and varies in results.

Case Description: The patient was a 34-year-old female, who was diagnosed with FSHD 3 years prior to our first visit. She had complaints of left shoulder pain (2-3/10), shoulder …

Parenteral Ascorbic Acid For Treatment Of Sepsis, Lindsey Hiatt

Physician Assistant Scholarly Project Posters

Sepsis kills nearly 1 million people each year in the United States and sepsis-related hospitalizations cost approximately $24 billion annually (Paoli, Reynolds, Sinha, Gitlin, & Crouser, 2018). Current treatment guidelines are limited to targeted antibiotics and hemodynamic support. While antibiotics are the definitive treatment to eradicate the infectious pathogen, there are currently no standard-of-care treatments that consistently and successfully attenuate the damage sustained to the body by its own inflammatory response to infection. Many different treatments have been trialed and failed to show improved outcomes. Vitamin C, or ascorbic acid, has long been associated with supporting immune function, and has …

Glucagon-Like Peptide-1s Compared To Sulfonylureas In The Treatment Of Adults Diagnosed With Type Ii Diabetes Mellitus In Primary Care, Tracy Kirchner

Physician Assistant Scholarly Project Posters

Type II diabetes mellitus (T2DM) is a prevalent disease in our country. Bullard et al. (2018) report approximately 21 million adults have T2DM in the United States. “The total estimated cost of diagnosed diabetes in 2017 is $327 billion, including $237 billion in direct medical costs and $90 billion in reduced productivity” (Yang et al., 2018). Treatment of T2DM is individualized to each patient based on their co-morbidities, fiscal responsibility, and route of administration options. Sulfonylureas and Glucagon-like Peptide-1s (GLP-1) are two classes of antidiabetic drugs that are available for use as second line treatment options after metformin. This review …

Obesity: Modern Medicine Vs. Lifestyle, Jenny Christianson

Physician Assistant Scholarly Project Posters

• Obesity is a rising epidemic, and is one of the most common, costly and preventable health problems the world is experiencing today (Center for Disease Control and Prevention, [CDC], 2017).

• From this, it is important to establish an effective treatment plan that can be implemented across the nation for maximum patient benefit.

• Lifestyle changes such as diet and exercise are important to any health care plan and are equally necessary to reduce health risks. However, in certain patients, lifestyle changes are not enough due to the maladaptive biologic process in their brain. Thus, additional treatment options need …

Collaboration Between Physical Therapy And Music Therapy: A Case Study Of The Interventions And Their Effects On Parkinson's Disease, Mercedes Stein, Kristyn Bergh

Physical Therapy Scholarly Projects

Background and Purpose: Parkinson's Disease is a chronic and progressive neurological disorder that causes motor dysfunction leading to dyskinesia, bradykinesia, muscular rigidity, resting tremors, postural impairments, and gait impairments. These impairments can have a tremendous negative impact on a person's everyday life. This case study demonstrates the collaboration of physical therapy and music therapy interventions and its effects on a female with Parkinson's Disease.

Case Description: The patient is a 72-year old female diagnosed with Parkinson's Disease around 2010. Her primary reason for seeking treatment is due to an increase in freezing of gait and overall decrease in mobility that …

The 20-M Shuttle Run: Assessment And Interpretation Of Data In Relation To Youth Aerobic Fitness And Health, Grant R. Tomkinson, Justin J. Lang, Joel Blanchard, Luc A. Léger, Mark S. Tremblay

Education, Health & Behavior Studies Faculty Publications

Cardiorespiratory fitness (CRF) is a good summative measure of the body’s ability to perform continuous, rhythmic, dynamic, large-muscle group physical activity, and exercise. In children, CRF is meaningfully associated with health, independent of physical activity levels, and it is an important determinant of sports and athletic performance. Although gas-analyzed peak oxygen uptake is the criterion physiological measure of children’s CRF, it is not practical for population-based testing. Field testing offers a simple, cheap, practical alternative to gas analysis. The 20-m shuttle run test (20mSRT)—a progressive aerobic exercise test involving continuous running between 2 lines 20 m apart in time to …

Physical Therapy Treatment For A Patient With A Hip Fracture And Cognitive Impairments: A Case Report, Tracie Boehmlehner

Physical Therapy Scholarly Projects

Background and Purpose: As the population shifts to include higher numbers of people in the elderly population, diseases and pathologies associated with geriatric populations will also increase. Two of these conditions are cognitive impairment and hip fractures. Hip fractures can be costly and life altering injuries. Treating patients with both of these conditions can pose a unique challenge to healthcare workers.

Case Description: The patient in this case study is a 78 year-old female who suffered a hip fracture secondary to a fall with a hip herniarthroplasty completed. She had many co-morbidities that are typical of an aging person such …

Test-Retest Reliability Of Trimp In Collegiate Ice Hockey Players, Jason G. Ulmer, Grant R. Tomkinson, Sandra E. Short, Martin Short, John S. Fitzgerald

Education, Health & Behavior Studies Faculty Publications

The utility of the heart rate derived variable TRaining IMPulse (TRIMP) for assessing internal training load in ice hockey players is not clear. Having a reliable measure of internal training load during on-ice training sessions would help coaches program exercise training. This study determined the reliability of TRIMP during on-ice training sessions in ice hockey players. Twelve Division I collegiate male ice hockey players (aged 18–23 years) had their heart rate (HR) data recorded during two on-ice practice sessions separated by two weeks. TRIMP and other descriptive HR variables were compared between sessions. TRIMP demonstrated moderate reliability during on-ice sessions. …

Enhancing Occupational Therapy’S Role In Reducing Hospital Readmission Rates For People With Cancer, Patrick Finnegan, Jared Skoog

Occupational Therapy Capstones

People with a cancer history have a high likelihood of hospital readmission after discharge due to limitations in functional abilities (Burke et al., 2016; Lee, Williams, Lalor, Brown, & Haines, 2018). Occupational therapy has a significant role in preventing hospital readmissions among people with cancer because of the focus on promoting functional abilities (Player, Mackenzie, Willis, & Loh, 2014). However, occupational therapy is infrequently used for people with cancer. In one research study, only 32% of people with cancer used occupational therapy within two years of their diagnosis (Pergolotti, Cutchin, Weinberger, & Meyer, 2014). The purpose of this scholarly project …

Wellness Programming For Men In Long-Term Care, Katie Hautman, Ashley Heinze

Occupational Therapy Capstones

Introduction: The purpose of this project was to develop a wellness guide for staff to implement in long-term care (LTC), to increase participation of meaningful activities and well-being for male residents of all abilities, both physically and psychosocially.

Methodology: A literature review was conducted to understand the need for activities of male residents in LTC. Sources included: online databases, textbooks, and government websites. The Canadian Model of Occupational Performance and Engagement (CMOPE) was selected to direct the development of the program guide. The CMOP-E promotes engagement in occupations and enablement of occupational performance, both of which are important for male …

Treatment Options For Post Treatment Lyme Disease Syndrome, Barbara Bowman

Oral History Posters

With the high incidence of Lyme disease in the endemic areas of North America, it is important to appropriately diagnosis and treat this condition to prevent post treatment Lyme disease syndrome (PTLDS).

Background information regarding Lyme disease is given. The purpose of this research is to discuss the treatment options available for those patients that fit the case definition of PTLDS. A literature review was conducted using several different electronic databases finding peer reviewed research articles pertaining to the treatment options available for PTLDS. Extended antibiotic use is shown to be not beneficial in most cases. Alternative treatment options listed …

Treatment Options For Post Treatment Lyme Disease Syndrome, Barbara Bowman

Physician Assistant Scholarly Project Posters

With the high incidence of Lyme disease in the endemic areas of North America, it is important to appropriately diagnosis and treat this condition to prevent post treatment Lyme disease syndrome (PTLDS). Background information regarding Lyme disease is given. The purpose of this research is to discuss the treatment options available for those patients that fit the case definition of PTLDS. A literature review was conducted using several different electronic databases finding peer reviewed research articles pertaining to the treatment options available for PTLDS. Extended antibiotic use is shown to be not beneficial in most cases. Alternative treatment options listed …

Early Aggressive Insulin Therapy In Type 2 Diabetes, Bryan Johnson

Physician Assistant Scholarly Project Posters

Metformin has been proven beneficial for the first-line treatment of type 2 diabetic mellitus (T2DM) due to its efficacy and low adverse effect profile. Current US guidelines do not address the use of early intensive insulin use in T2DM. Treatment plans are slowly adjusted over the months until the A1C goal is met. Insulin is initiated several years after the time of T2DM diagnosis and utilized as second-line therapy. Dual therapy of insulin and metformin have shown regression of T2DM in certain patient populations. However, the linear relationship between diabetes and cardiovascular disease does not show greater improvement with dual …

Managing Anxiety With Pharmacogenomic Testing, Ashley Pommer

Physician Assistant Scholarly Project Posters

Anxiety affects approximately three to seven percent of the United States population, and nearly 50% of the diagnosed patients fail to respond to first-line treatment regimens (Boland, Duffy, & Meyer 2018). Traditional first-line treatments include medication therapy, cognitive behavioral therapy (CBT), or the combination of both. With such a high initial failure rate, recent studies indicate promising results in managing anxiety with pharmacogenomic testing. Pharmacogenomic testing is allowing providers to prescribe medication based on individual genetic makeup, focusing on how each patient metabolizes certain medications. The purpose of this literature review was to determine if first-line methods or pharmacogenomic testing …

Delaying Diabetes In The Native American Population, Seth Tramm

Physician Assistant Scholarly Project Posters

Diabetes is a debilitating disease process caused by the body’s inability to control blood glucose levels. With over 30 million diabetics in the United States and another 85 million prediabetics, the effects of this disease are wide-spread and far-reaching. Native American/Alaska Native populations have a nearly two-fold increase in prevalence of diabetes when compared to non-native populations. Risk factors for diabetes in all populations include modifiable risks such as obesity, diet, and physical inactivity as well as non-modifiable factors such as age, family history, and ethnicity. Studies have shown that early identification of symptoms, coupled with proper and intentional treatment …

Intermittent Fasting In Weight Management, Alse Engen

Physician Assistant Scholarly Project Posters

Obesity is associated with a variety of medical conditions that adversely affect metabolic and cardiovascular health. In order for health care providers to adequately educate and promote weight management, they need to be aware of the various dietary regimens and the efficacy and adverse effects associated with each. This literature review assesses the efficacy, metabolic benefits, and cardiovascular benefits of both intermittent energy restriction and continuous energy restriction from ten articles found on various databases within the past five years. The findings indicate that although not proven superior or inferior, intermittent energy restriction provides statistically similar results to continuous energy …

Parenteral Ascorbic Acid For Treatment Of Sepsis, Lindsey Hiatt

Physician Assistant Scholarly Project Posters

Sepsis kills nearly 1 million people each year in the United States and sepsis-related hospitalizations cost approximately $24 billion annually (Paoli, Reynolds, Sinha, Gitlin, & Crouser, 2018). Current treatment guidelines are limited to targeted antibiotics and hemodynamic support. While antibiotics are the definitive treatment to eradicate the infectious pathogen, there are currently no standard-of-care treatments that consistently and successfully attenuate the damage sustained to the body by its own inflammatory response to infection. Many different treatments have been trialed and failed to show improved outcomes. Vitamin C, or ascorbic acid, has long been associated with supporting immune function, and has …

Delaying Diabetes In The Native American Population, Seth Tramm

Physician Assistant Scholarly Project Posters

Diabetes is a debilitating disease process caused by the body’s inability to control blood glucose levels. With over 30 million diabetics in the United States and another 85 million prediabetics, the effects of this disease are wide-spread and farreaching. Native American/Alaska Native populations have a nearly two-fold increase in prevalence of diabetes when compared to non-native populations. Risk factors for diabetes in all populations include modifiable risks such as obesity, diet, and physical inactivity as well as non-modifiable factors such as age, family history, and ethnicity. Studies have shown that early identification of symptoms, coupled with proper and intentional treatment …