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Volume 56, Number 27: February 20, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

A Network Pharmacology Approach For The Identification Of Common Mechanisms Of Drug-Induced Peripheral Neuropathy, Guillermo De Anda Jauregui, Brett A. Mcgregor, Kai Guo, Junguk Hur

Biomedical Sciences Faculty Publications

Drug-induced peripheral neuropathy is a side effect of a variety of therapeutic agents that can affect therapeutic adherence and lead to regimen modifications, impacting patient quality of life. The molecular mechanisms involved in the development of this condition have yet to be completely described in the literature. We used a computational network pharmacology ap-proach to explore the Connectivity Map, a large collection of transcriptional profiles from drug perturbation experiments to identify common genes affected by peripheral neuropathy-inducing drugs. Consensus profiles for 98 of these drugs were used to construct a drug–gene perturbation network. We identified 27 genes significantly associated with …

Volume 56, Number 26: February 13, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

Do People Who Identify As Popular Become Popular In A New Network? A 9-Month Longitudinal Network Analysis, Christopher J. Carpenter, Xun Zhu, Rachel A. Smith

Communication Faculty Publications

Although scholars have argued that people actively shape and reshape their social networks (e.g., Parks, 2016), this aspect of relational development has received little attention. This study sought to determine if people’s self-perceptions of interpersonal communication skills translated into behavior that led to relationship formation in a new network. A 9-month longitudinal social network analysis (N = 94) of the residents of a first-year university residence hall using Facebook tie data was conducted to assess network changes. Results indicate that both self-perceived network centrality in a hypothetical friendship sociogram (Smith & Fink, 2015) and self-reported connector scores (Boster et al., …

Volume 56, Number 25: February 06, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

Febuary 5, 2019, The Dakota Student

The Dakota Student

No abstract provided.

February 7, 2019: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the February 7, 2019, meeting of the University Senate. 18 pages

This meeting was cancelled due to the weather.

Use Of Beta-Antagonists For Cardioprotection During Chemotherapy In Oncology Patients, Nicole Streich

Physician Assistant Scholarly Project Papers

No abstract provided.

Und Today: February 2019, University Of North Dakota

UND Today Archive

No abstract provided.

Predictors Of Assertive And Nonassertive Styles Of Self-Defense Behavior During A Lab-Based Sexual Assault Scenario, Raeann E. Anderson, Shawn P. Cahill, Kristin E. Silver, Douglas D. Delahanty

Psychology Faculty Publications

The current study examined how psychological factors influence hypothetical behavioral responses to threat (BRTT). College women (n = 113) with a history of sexual victimization completed a standardized lab-based self-defense scenario. Interpersonal skills, coping style, and assertive and non-assertive BRTT during a prior assault predicted assertive BRTT during the task. The use of non-assertive BRTT during past assaults no longer predicted assertive BRTT during the task when accounting for rape acknowledgment. Findings regarding rape acknowledgment demonstrate the complexity of recovery from sexual assault. Our results highlight interpersonal skills as an intervention target for innovative sexual assault risk reduction interventions.

Differences In Rape Acknowledgement And Mental Health Outcomes Across Transgender, Non-Binary, And Cisgender Bisexual Youth, Raeann E. Anderson, Lesley A. Tarasoff, Nicole Vankim, Corey Flanders

Psychology Faculty Publications

The purpose of this study was to document the rates of rape acknowledgment (labeling rape as rape rather than using a minimizing label) and the corresponding mental health correlates using the minority stress framework in a unique and vulnerable sample: racially diverse sexual and gender minority young adults. Participants were 245 young adults who identified their sexual orientation as under the bisexual umbrella. A total of 159 of these participants (65.2%) identified their gender identity as nonbinary. All participants completed a series of online questionnaires regarding their sexual victimization history, mental health outcomes (depression, anxiety, and posttraumatic stress disorder [PTSD]), …

Parenteral Ascorbic Acid For Treatment Of Sepsis, Lindsey Hiatt

Physician Assistant Scholarly Project Papers

Sepsis kills nearly 1 million people each year in the United States and sepsis-related hospitalizations cost approximately $24 billion annually (Paoli, Reynolds, Sinha, Gitlin, & Crouser, 2018). Current treatment guidelines are limited to targeted antibiotics and hemodynamic support. While antibiotics are the definitive treatment to eradicate the infectious pathogen, there are currently no standard-of-care treatments that consistently and successfully attenuate the damage sustained to the body by its own inflammatory response to infection. Many different treatments have been trialed and failed to show improved outcomes. Vitamin C, or ascorbic acid, has long been associated with supporting immune function, and has …

Intermittent Fasting In Weight Management, Alyse Engen

Physician Assistant Scholarly Project Papers

Obesity is associated with a variety of medical conditions that adversely affect metabolic and cardiovascular health. In order for health care providers to adequately educate and promote weight management, they need to be aware of the various dietary regimens and the efficacy and adverse effects associated with each. The purpose of this study is to analyze research assessing the efficacy and health benefit of intermittent energy restriction and compare to the efficacy and health benefits of continuous energy restriction. This literature review assesses the efficacy, metabolic benefits, and cardiovascular benefits of both intermittent energy restriction and continuous energy restriction from …

Delaying Onset Of Diabetes In Native American Populatons, Seth Tramm

Physician Assistant Scholarly Project Papers

Diabetes is a debilitating disease process caused by the body’s inability to control blood glucose levels. With over 30 million diabetics in the United States, and another 85 million prediabetics, the effects of this disease are wide-spread and far-reaching. Native American/Alaska Native populations have a nearly two-fold increase in incidence of diabetes when compared to non-native populations. Risk factors for diabetes in all populations include modifiable risks such as obesity, diet, physical inactivity as well as non-modifiable factors such as age, family history, and ethnicity. Studies have shown that early identification of symptoms, coupled with proper and intentional treatment can …

Volume 56, Number 24: January 30, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

Parp-1/2 Inhibitor Olaparib Prevents Or Partially Reverts Emt Induced By Tgf-Β In Nmumg Cells, Michelle Schacke, Janani Kumar, Nicholas Colwell, Kole Hermanson, Gustavo A. Folle, Sergei Nechaev, Archana Dhasarathy, Laura Lafon-Hughes

Biomedical Sciences Faculty Publications

Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2). PARP-1 is nuclear and has also been detected in extracellular vesicles. PARP-2 and TNKS-1/2 are distributed in nuclei and cytoplasm. PARP or PAR alterations have been described in tumors, and in particular by influencing the EpithelialMesenchymal Transition (EMT), which influences cell migration and drug resistance in cancer cells. Pro-EMT and anti-EMT effects of PARP-1 have been reported while whether PAR changes occur specifically during EMT is currently unknown. The PARP-1/2 inhibitor Olaparib (OLA) is …

Volume 56, Number 22: January 16, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

January 15, 2019, The Dakota Student

The Dakota Student

No abstract provided.

Investigating Graduate Education And Undergraduate Research Intentions Of College Science Students, Eric D. Deemer, Rachel L. Navarro, Angela M. Byars-Winston, Laura E. Jensen, Catherine P. Chen

Education, Health & Behavior Studies Faculty Publications

The current study examined predictors of undergraduate science students’ intentions to attend graduate school and participate in undergraduate research. We used social cognitive career theory to test our hypothesized model using a sample (N ¼ 411) of life science and physical science majors and examined basic interests in these disciplines as mediating variables. Among life science majors, results of structural equation modeling indicated that microbiology interest mediated the relationship between scientific self-efficacy (SSE) and graduate education intentions (GEIs) and the latter variable also mediated the relationship between microbiology interest and undergraduate research intentions (URIs). The model for physical science majors …

Volume 56, Number 21: January 09, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 56, Number 20: January 02, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

A Comparison Of Two In-Class Anxiety Reduction Exercises Before A Final Exam, Virginia Clinton, Stacy Meester

Educational Foundations and Research Faculty Publications

The purpose of this quasi-experiment is to test two different methods for helping students reduce anxiety before an exam. Students in two introductory psychology courses (N = 111) engaged in either a focused-breathing or expressive-writing exercise before their final exam. Results indicated that, compared to previous exam performance, both focused breathing and expressive writing improved performance for students with high levels of trait test anxiety. However, there was no effect on final exam performance for either method for students with low levels of trait test anxiety. Both exercises appeared to reduce state anxiety for students, although the reduction was greater …

Ca2+ Entry Via Trpc1 Is Essential For Cellular Differentiation And Modulates Secretion Via The Snare Complex, Thad A. Rosenberger, Anne Schaar, Yuygang Sun, Pramod Sukumaran, Danielle Krout, James N. Roemmich, Lutz Brinbaumer, Kate Claycombe-Larson, Brij B. Singh

Biomedical Sciences Faculty Publications

Adipocyte functionality, including adipocyte differentiation and adipokine secretion, is essential in obesity-associated metabolic syndrome. Here, we provide evidence that Ca2+ influx in primary adipocytes, especially upon store-depletion, plays an important role in adipocyte differentiation, functionality, and subsequently metabolic regulation. The endogenous Ca2+ entry channel in both subcutaneous and visceral adipocytes was dependent on TRPC1-STIM1 and blocking Ca2+ entry with SKF-96365 or TRPC1-/- derived adipocytes inhibited adipocyte differentiation. Additionally, TRPC1-/- mice have decreased organ weight, but increased adipose deposition and reduced serum adiponectin and leptin concentrations, without affecting total adipokine expression. Mechanistically, TRPC1- mediated Ca2+ entry regulated SNARE complex formation and …

A Website Designed To Equip Occupational Therapists With Information And Strategies For Holistically Addressing Sexual Activity With The Geriatric Population, Amber Fernandez, Ashleigh Mora

Occupational Therapy Capstones

As individuals age, they are likely to experience occupational deprivation. Occupational deprivation occurs in many forms. Many older adults experience occupational deprivation relating to the activity of daily living, sexual activity. Older adults experience many age-related changes, which impacts their ability to engage in sexual activity. Health care professionals have a responsibility to ensure older adults are able to engage in safe sexual practices. Yet, healthcare professionals, including occupational therapists, are not addressing this need with their clients in a routine manner. A literature review was conducted in order to gain a comprehensive understanding of all the barriers older adults …

Creating A Sensory Inclusive Classroom: A Guide For Teachers, Bobbie Bertsch, Kylie Browen

Occupational Therapy Capstones

A school classroom is the place where students are expected to complete the majority of their learning. Many classrooms have a large amount of distracting sensory stimuli such as bright lights, visual stimuli on the walls, noises from individuals within the room, and sensory rich learning experiences. The physical environment can affect children's learning and attention (Miller-Kuhaneck & Kelleher, 2015). Based on an in-depth literature review, it has been found that certain components of the classroom can be altered to create an environment more inclusive for all children, regardless of abilities. In light of the push to keep children in …

Life History Of Dr. Neil Harvison Phd, Otr, Fnap, Faota, Kaylee Loken, Bailey Schumacher

Oral History Student Papers

Objective: The purpose of study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond.

Method: The participant was selected from a participant list compiled through purposive sampling by the project directors. Informed consent was obtained prior to the interview. The project was reviewed by the UND Institutional Review Board and was exempted due to it being a life history. A semi-structured interview …

Life History Of Margo B. Holm, Phd, Otr/L, Faota, Abda, Emma Chafin, Jessica Lambert

Oral History Posters

This life history is one of 30 life history interviews which are part of a larger project, Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) at the National Level and Beyond. The purpose of study is to provide current and future generations of occupational therapists a view of the history and how occupational therapy practice has evolved from its inception to current practice through the life history stories of occupational therapists who have held leadership roles at the national level and beyond. It is anticipated that the life history process will be a powerful way to …

Evolution Of Occupational Therapy: A Life History Of Dr. Michael Iwama, Phd, Msc, Bscot, Bschp, Sarah Lovelace, Annabelle Tarnowski

Oral History Posters

A life history interview with a qualitative approach was conducted with Michael Iwama, PhD, MSc, BScOT, BScHP by two student researchers and an advisor from the University of North Dakota Department of Occupational Therapy. The purpose of this study is to provide occupational therapists with a view of history and how occupational therapy practice has evolved from inception to current practice through the life history of Michael Iwama. The research was guided by the Kawa model to shape the interview schedule, and the view of the individual and their context (Iwama, Thomson, & Macdonald, 2009). The two-hour interview was recorded, …

Intermittent Fasting In Weight Management, Alyse Engen

Physician Assistant Scholarly Project Posters

Obesity is associated with a variety of medical conditions that adversely affect metabolic and cardiovascular health. In order for health care providers to adequately educate and promote weight management, they need to be aware of the various dietary regimens and the efficacy and adverse effects associated with each. This literature review assesses the efficacy, metabolic benefits, and cardiovascular benefits of both intermittent energy restriction and continuous energy restriction from ten articles found on various databases within the past five years. The findings indicate that although not proven superior or inferior, intermittent energy restriction provides statistically similar results to continuous energy …

Comparing Rates Of Macrosomia And Neonatal Hypoglycemia Of Differing Treatment Modalities Of Gestational Diabetes Mellitus, Ashleigh Milbrath

Physician Assistant Scholarly Project Posters

Gestational diabetes mellitus (GDM) is a known potential complication that can occur during pregnancy. Unmanaged GDM can result in maternal hyperglycemia, which can cause increased neonatal complications, two of which are macrosomia and neonatal hypoglycemia. To prevent maternal hyperglycemia, treatment of GDM typically begins with dietary changes, home glucose monitoring, increased exercise patterns and other lifestyle modifications. However, if maternal hyperglycemia persists after two weeks of maternal lifestyle modifications, there are not current best practice guidelines established for the treatment of GDM. Historically, subcutaneous multiple daily dosed insulin (MDI) has been the gold standard for treatment after lifestyle modification. However, …