Digital Commons Network^™

Impacts Of Cold Region Hydroclimatic Variability On Phosphorus Exports: Insights From Concentrations - Discharge Relationships, Tyson Lee Jeannotte

Theses and Dissertations

In Devils Lake ND, a terminal lake in the Northern Great Plains, algae blooms are of great concern due to the recent increase of streamflow and subsequent elevated concentrations of nutrients, particularly phosphorus. To date, very few studies explore P concentration to streamflow relationship in cold region agricultural basins, specially the headwater catchments of the Devils Lake basin. This study gains a better understanding of the impacts of hydroclimatic variation on concentration to streamflow relationships between two headwater catchments (Mauvais Coulee: 1032 km2 and Tributary 3: 160 km2) draining to Devils Lake during the 2016-2018 period. This study presents high-resolution …

Writing The Body: Embodied Forms And Animal Spirits, Andrew Harnish

Theses and Dissertations

“Writing the Body: Embodied Forms and Animals Spirits” is comprised of a critical introduction and a novel. The critical introduction, “Embodied Forms: One Writer’s Journey from an Ableist Aesthetic to Disability Consciousness” is a literacy narrative that traces my longstanding internalization of ableist norms and their expression in my fiction, and my gradual embrace of the value of disability as an identity and aesthetic sensibility. In so doing, the introduction argues that dominant notions of “normalcy,” “perfection,” and “beauty” are deeply damaging to the disabled writers who internalize them because they encourage the creation of art that erases disability, both …

Sparc, A Matricellular Protein, In A Cell Culture Model Of Heavy Metal Cadmium Induced Bladder Urothelial Carcinoma, Emily Rae Biggane

Theses and Dissertations

Bladder cancer, the most common urinary tract malignancy, has environmental toxicant exposure as one of its biggest risk factors. This lab examines potential biomarkers employing an in vitro model of urothelial carcinoma using a normal bladder cell line and its malignantly transformed cells transformed counterpart, transformed by exposure to long term, low doses of cadmium (Cd2+). Initial microarray analysis determined that Secreted Protein Acidic and Rich in Cysteine (SPARC) was the most repressed gene across all transformed cell lines compared to its normal counterpart (Garrett et al., 2014, Larson et al., 2010).

SPARC, an extracellular matrix glycoprotein, functions by regulating …

Alpha1a-Adrenergic Receptor Modulation Of Epileptiform Activity And Seizures, Joseph Patrick Biggane

Theses and Dissertations

The research herein aimed to increase our understanding about potential roles of adrenergic receptor subtypes in epileptic seizures and seizure-like (epileptiform) phenomena. Previous observations in our laboratory led us to hypothesize that the alpha1A-adrenergic receptor is a critical component of the modulatory role of the alpha1-adrenergic receptor, and more broadly, norepinephrine, on epileptiform and seizure activity. We utilized a combination of genetic and pharmacological manipulation to elucidate specific effects of the alpha1A-adrenergic receptor subtype on altering hyperactivity in models of epilepsy, both in slice and in vivo. This research sought to address three main research questions: (1) What are the …

An Evaluation Of Remote Sensing Methods For Ecological Management In Theodore Roosevelt National Park, Jenna Folluo

Theses and Dissertations

This thesis is comprised of four chapters that examine various aspects of remote sensing for ecological management in Theodore Roosevelt National Park. Chapter one reviews the use of remote sensing as a management tool and discusses its applications in TRNP. Chapter two describes the application of multiple remote sensing methods and how well they can detect and map invasive vegetation, particularly leafy spurge. Chapter three provides a study on defining and mapping vegetation communities in TRNP at varying spatial scales. Chapter four explores the use of remote sensing techniques to detect prairie dog mounds and map colonies.

Occupational Therapy Community Reintegration For Inmates With Co-Occurring Disorders, Miranda Hosking, Kara Moore

Occupational Therapy Capstones

A co-occurring disorder (COD) is the coexistence of a substance use disorder and mental health disorder (Substance Abuse and Mental Health Services Administration, 2016). The prevalence of inmates with COD in correctional facilities is disproportionately high (Grant, Stinson, & Dawson, 2004). Despite the high incidence, correctional facilities are not equipped to meet the complex needs of individuals with COD, which often leads these individuals to re-offending or re-incarceration (Sacks, Chaple, Sacks, McKendrick, & Cleland, 2012). The role of occupational therapy in this area of practice is not clearly distinguished. However, occupational therapy’s holistic, client-centered, and occupation-based principles position the profession …

Occupational Therapy At Stable Days: Supporting A Christian Worldview, Liz Nerhus, Jordan Mooney

Occupational Therapy Capstones

Purpose: The purpose of this project was to provide a framework for use by an occupational therapist providing integrated services from a Christian worldview perspective within a faith-based setting.

Methodology: An extensive literature review was completed on the topics of occupational therapy in integrated faith-based settings, with an emphasis on spirituality, experience of practitioners, current tools of the profession, and the basic tenants of the Christian faith. The search databases used included: CINAHL, OTSEARCH, Pubmed, SocIndex, and PsycINFO. The literature review revealed that nearly 80% of Americans identify spirituality as an important part of their life (Williams-Reade, Lobo and Gutierrez, …

Avian Igy As An Immunotherapy For Flaviviral Infections, Kyle O'Donnell

Theses and Dissertations

Flaviviruses compose a group of positive single strand RNA viruses. This group possess 70 individual viruses that cause disease in humans and animals. This group contains the most prevalent arbovirus dengue virus (DENV) and a recently emerging arbovirus zika virus (ZIKV). Both DENV and ZIKV represent significant world health threats and both viruses, at the moment, are contained to tropical and sub tropical regions due to vector habitat restrictions. DENV can cause severe hemorrhagic fever termed dengue hemorrhagic fever and dengue shock syndrome depending on the extent of vascular permeability. The disease burden attributed to dengue infection is approximately 390 …

Digital Image Processing And Metabolic Parameter Linearity To Noninvasively Detect Analyte Concentration, Joseph Allen Jr

Theses and Dissertations

Spectroscopy is the scientific technique of quantifying and measuring electromagnetic, or light, reflectance or absorption. Atoms emit and/or absorb light when light passes through. The excitations provide specific energy signatures that relate to the element that is emitting or absorbing the light. Non-invasive biosensors monitor physical health properties such as heart rate, oxygen saturation, and tissue blood flow as a result of spectroscopy. Several attempts have been made to non-invasively detect metabolic chemical, or analyte, concentration with various spectroscopic techniques. The primary limitation is due to signal-to-noise ratio. This research focuses on a unique method that combines emission spectroscopy and …

Curators Of Place: Farmers' Narratives Of Sense Of Place And Learning, Matthew Alan Berosik

Theses and Dissertations

This dissertation brings forth the idea that our attachment to place and the meanings behind those attachments could be well suited for implementation within formal agricultural education. The focus of this dissertation brings to light multi-generational family farmer’s attachment to the places they grew up and work on, as well as prepare their children and grandchildren to take on the role of ‘curator of place’. Throughout this dissertation, I lay the groundwork for inclusion of sense of place within formalized agricultural education by highlight just what sense of place is and the missing areas within current agricultural education. For this …

Interplay Between Environmental Signals And Chromatin Remodeling During The Process Of Epithelial To Mesenchymal Transition (Emt), Atrayee Bhattacharya

Theses and Dissertations

The process of epithelial to mesenchymal transition (EMT), in which epithelial cells assume a mesenchymal cell phenotype with enhanced migratory capacity plays an integral role in development and wound healing but also contributes pathologically to fibrosis and cancer progression. This switch in cell differentiation and behavior is mediated by key transcription factors like SNAI1 (SNAIL) and SNAI2 (SLUG) in response to several signaling pathways like TGF-β and EGF. There are three key events that occur during TGF-β induced EMT, namely extracellular cues that must be transmitted to the nucleus to elicit activation of SNAI1 transcription, recruitment of transcription factors (TFs) …

Applications Of An Unmanned Aircraft Vehicle And Remote Cameras For Studying A Sub-Arctic Ecosystem, Andrew Barnas

Theses and Dissertations

The midcontinent population of lesser snow geese (Anser caerulescens caerulescens) has increased dramatically since the 1960’s due to changing agricultural practices in their southern wintering areas. The destructive foraging and continued population growth of lesser snow geese has resulted in cascading negative impacts on northern ecosystems. Studying remote sub-Arctic ecosystems is logistically challenging, but the advent of remote sensing technologies (such as drones and remote cameras) may assist ecologists in understanding snow goose ecology. Before these tools can be integrated into snow goose research programs, precursor “proof-of-concept” studies are required to validate tool use. The objectives of this study were …

Tissue Specific Gene Expression In Chelydra Serpentina, Jasmine Carly Kasanke

Theses and Dissertations

Epigenetic regulation has been studied in mammals, but research in reptiles is lacking. Knowing where specific genes are expressed is the first step to examining epigenetic regulation of tissue specific and cell-type specific gene expression. Differences in gene expression allude to differences in gene regulation and gene function and will require further study. In order to address the question of tissue specific gene expression, we review literature on embryonic development, sex determination, and specific genes that display tissue specific or cell-type specific expression patterns. Next, we review what is known about regulation of gene expression in reptiles. We then outline …

Design Of A Controlled Descent Lifting Body Glider For High Altitude Payload Recovery, Nanette Valentour

Theses and Dissertations

A lifting body scaled glider to be used as a recovery method for high altitude ballooning payloads has been developed at the University of North Dakota. Current recovery techniques for balloon payloads consist of monitoring and chasing the payload signal until it can be recovered. It is expected that a lifting body glider can reduce the distance for payload recovery and in some cases effectively return the payload back to the Ground Station. A preliminary subsonic aerodynamic model has been developed using MATLAB and the Vortex Lattice Method (VLM). Traditional evaluation techniques typical for calculation of the aerodynamic coefficients are …

On Satyrs: Brutes, Monsters, And Demons: Of Their Nature And Worship: François Hédelin's Des Satyres As A Defense Of God And Humankind, Danielle Skjelver

Theses and Dissertations

Best known for his 1657 La Pratique du Theatre, François Hédelin was a cleric with a keen interest in the stage. As the abbé d’Aubignac, he wrangled in debate with the most respected scholars of his day, and Hédelin’s contacts extended to the crown itself. His Des Satyres, brutes, monstres et démons is an attempt to do with a species what he did with the stage - to bring disorder and immorality to heel.

This dissertation provides historical context, analysis, and translation of François Hédelin’s 1627 Des Satyres, brutes, monstres et démons. De leur nature et adoration Contre l'opinion de …

Paleoecology Of Northern Great Plains Bison: Inferences From Stable Isotopes And Dental Calculus, Gaimi Lynn Davies

Theses and Dissertations

The purpose of this study is to infer Northern Great Plains bison (Bison bison) paleoecology through the analysis of stable isotopes and dental calculus from bison skeletal remains. Bison used to roam in the millions throughout most of North America but today they are primarily kept in confined and isolated populations. Little is known about their ancestral ecology. The abundance of bison in the archeological record provides a unique opportunity to study their remains on a broad temporal and spatial scale. This research uses the archeological record of bison in North Dakota to study bison diet and environment from the …

Characterization Of Dopamine Transporter Amino Terminal Palmitoylation And Neurotoxic Substrate Activity, Daniel Jacob Stanislowski

Theses and Dissertations

The projects described in this dissertation revolve around the functional consequences experienced by the transport protein for the neurotransmitter dopamine resulting from alterations to its palmitoylation condition or exposure to Parkinson disease-inducing transport substrates. This membrane-resident transport protein, pragmatically termed the dopamine transporter, relocates dopamine from extracellular areas of receptor sites of action to intracellular sequestration; the dopamine transporter is a powerful mediator of dopamine signaling. As such, genetic, toxicant, or chronic breakdown of dopamine transporter function is associated with multiple psychological abnormalities. Biomedical research has produced several pharmacotherapies for maladies like depression, attention deficit/hyperactivity disorder, and addiction, some of …

Presence And Characterization Of Microplastics In Drinking (Tap/Bottled) Water And Soft Drinks, Mansurat Golden Abdulmalik Ali

Theses and Dissertations

This study investigates the presence of microplastics in human consumable products using 33 samples; Fifteen tap water samples, nine bottled water and nine soft drink samples, collected and purchased in Grand Forks, ND.

Tap water analysis confirm all samples contain microplastics, majority of which were fibres and fragments with 48.6% and 41.8% abundance. The average concentration was 182 mpp/L (range 66 mpp/L – 472 mpp/L) with 2.5 µm – 3 mm size range. Bottled water and soft drinks were also contaminated with microplastics with an average of 101 mpp/L (range 49 mpp/L – 166 mpp/L) and particle size ranging from …

Review Of Sex Determination In Fish And Reptiles And Estimation Of Sex Ratio Heritability In The Common Snapping Turtle, Kyle Hilliard

Theses and Dissertations

Sex-determining mechanisms in fish and reptiles are incredibly diverse. We first review sex-determination in these groups, including approaches that can be used to identify sex-determining genes and the large body of research showing genetic variation for sex ratio in species with temperature-dependent sex determination (TSD). We then show that sex ratio variation among clutches is due to additive genetic effects in one TSD species, the common snapping turtle. This finding contradicts previous claims that non-genetic maternal factors such as yolk steroid hormones are driving sex determination in this species. Heritable variation for sex determination in the snapping turtle may allow …

The Relationship Of Physical Activity And Perceived Fatigue In Men Receiving External Beam Radiation Therapy For Non-Metastatic Prostate Cancer, Timothy Charles Flory Fuss

Theses and Dissertations

Nature of the Problem/Study

Prostate cancer is the second most common cancer in men in the United States, with 2.9 million men diagnosed with prostate cancer alive today (American Cancer Society, 2017). Given the rate of survival and substantial number of men living with prostate cancer, addressing symptoms and quality of life in these men is increasingly important.

Fatigue is reported to be the most distressing side effect of radiation therapy (RT), negatively effecting physical function and quality of life (Minton et al., 2013). Finding measures to predict, treat and help prevent fatigue can improve long term outcomes in cancer …

Native And Indigenous Women Of Hawai'i: Exploring The Importance Of Indigenous Narratives And Storytelling To Understand Ancestral Knowledge Systems, Renuka Mahari De Silva

Theses and Dissertations

This dissertation contains three articles. The research for these articles was conducted through many interviews and working directly in the communities from around the Island of O ‘ahu, Hawai‘i. Each article addresses a research topic that is connected to ancestral stories and historical events brought forward by women through stories and storytelling. These stories embed rich ancestral knowledge from a specific time and a specific place and space. In reading these articles, the reader is exposed to the power of story and storytelling, and how that in turn, reconnects people to places to learn from ancestral knowledge, and apply these …

Enhancement Of Retention Of Heavy Metals By Storm Water Structural Best Management Practices, Nicholas Reid Peterson

Theses and Dissertations

Batch and column experiments were performed on wide range of adsorbent materials for the adsorption of copper (II) ion from aqueous solution. The objective of this research was to determine a suitable material to be applied in urban stormwater control measures such as low impact developments that will increase the pollutant reduction efficiency of the structure, specifically increase heavy metal retention. Materials analyzed in this research are wood chips, tree leaves, rice husk, biochar, modified iron-coated sand and flocculated alum particles. Batch experiments determine the maximum adsorption capacity of each material under a range of metal and adsorbent dosages. Column …

Relationships Between Sibling Physical Abuse And Lifetime Aggression Using Statistical Controls For Poly-Victimization, Ani Celine Mangold

Theses and Dissertations

Sibling abuse, as a potential contributor to lifetime aggression, is under-represented in the childhood maltreatment literature and minimized in American society. A contemporary survey study conducted using a large college sample (King et al., 2017) established significant relationships between sibling abuse (i.e., acts of physical abuse, threats of violence, and heated verbal conflict) and a range of lifetime aggression indicators after controlling for variance attributable to physical, sexual, intimate partner, and peer abuse. The present study examined sibling physical abuse and established these same relationships using a national sample after controlling for variance due to childhood physical abuse, observed violence …

Reproductive Strategies Of Common Eiders (Somateria Mollissima), Samuel Donald Hervey

Theses and Dissertations

Many reproductive strategies exist all with the same goal to maximize fitness. Because reproductive strategies affect fitness directly, there is interest to understand how they are utilized within a population. The two main strategies we focus on for this work related to Common Eiders (Somateria mollissima) are the utilization of conspecific brood parasitism as an alternative tactic beyond simply nesting and their ability to shift timing of breeding to align young with the best opportunity for survival. To accomplish studying our two reproductive strategies we monitored the Mast and WaWao Common Eider colonies located within Wapusk National Park, Manitoba. Our …

Inflammation Is A Common Factor Between Central And Peripheral Neurodegeneration, Brett Anthony Mcgregor

Theses and Dissertations

The studies in this dissertation investigate neurodegenerative conditions of the central and peripheral nervous system utilizing bioinformatics and systems biology approaches. Various neurodegenerative conditions are associated with neuroinflammation or the inflammation of nervous tissue. We utilized Parkinson’s disease as our system for neuroinflammation in the central nervous system and diabetic peripheral neuropathy for the peripheral nervous system. Parkinson’s disease is associated with loss of dopaminergic neurons in the substantia nigra and consequent loss of dopamine signaling in the striatum of the central nervous system. Characteristics of Parkinson’s Disease include symptoms such as shaking, rigidity, slowness of movement, difficulty walking, dementia, …

Hunting And Fishing Attitudes, Behaviors And Ethics Related To Gender And Aggression, Victoria Williams

Theses and Dissertations

To date, no empirical studies have investigated the relationship between psychopathology (or other constructs) pertaining to hunting and fishing attitudes, behaviors and ethics relating to gender and aggression. Although experienced outdoorspeople assumedly adhere to, or are at least aware of, general hunting and fishing codes of ethics, many disregard them. This study investigates the differences between men and women on these variables by utilizing a newly developed measure of hunting and fishing attitudes and beliefs, the Sportsperson Attitude Scale (SAS) (McDonald, Williams, Sargent & McDonald 2017). This measure was created in order to better understand the potential motivators and reinforcers …

The Effects Of Psychotropic Medications On Developing Brains, Abass Jafuneh

Nursing Capstones

No abstract provided.

Treatment Challenges Of Delusional Disorders, Amanda Mikhaeil

Nursing Capstones

No abstract provided.

Psychostimulants And Psychosis, Cherri L. Runde

Nursing Capstones

No abstract provided.

The Urothelial Cell Line Urotsa Transformed By Arsenite And Cadmium Display Basal Characteristics Associated With Muscle Invasive Urothelial Cancers, Zachary E. Hoggarth, Danyelle B. Osowski, Brooke A. Freeberg, Scott H. Garrett, Mary Ann Sens, Xudong Zhou, Ke K. Zhang, Seema Somji

Pathology Faculty Publications

Muscle invasive urothelial carcinomas are divided into various molecular subtypes with basal and luminal subtypes being the prominent ones. The basal muscle-invasive urothelial carcinomas are generally more aggressive at presentation and significantly enriched with squamous features. Our laboratory has developed an in-vitro model of urothelial cancer by transforming the immortalized cell line UROtsa with arsenite (As3+) and cadmium (Cd2+). In this study, we characterized the tumors formed by these transformed cell lines as more basal-like based on their gene expression patterns with increased expression of KRT1, KRT5, KRT6, KRT14, KRT16, KRT17 and CD44. In addition, histological examination of these tumor …