Digital Commons Network^™

Dynamic Imaging Of Ldh Inhibition In Tumors Reveals Rapid In Vivo Metabolic Rewiring And Vulnerability To Combination Therapy, Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P Norenberg, W Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers

Pathology Research and Scholarship

The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to determine whether LDH is a feasible drug target are lacking. We describe an LDHi with potent, on-target, in vivo activity. Using hyperpolarized magnetic resonance spectroscopic imaging (HP-MRSI), we demonstrate in vivo LDH inhibition in two glycolytic cancer models, MIA PaCa-2 and HT29, and we correlate depth and duration of LDH inhibition with direct anti-tumor activity. HP-MRSI also reveals a metabolic rewiring that occurs in vivo within 30 min …

Improving The Delivery Of Musculoskeletal Education In Primary Care Using The Innovative Echo (Extension For Community Healthcare Outcomes) Technology, Katharine Spalding, Ian Ryans, Neil Heron

Project ECHO Bibliography

Background: Extension for Community Healthcare Outcomes (ECHO) is a programme that employs videoconferencing technology to train community-based primary care providers to improve and standardize care across a wide geographical region. This method has not yet been trialled in the UK for improving the capacity of primary care services in managing common musculoskeletal (MSK) complaints.

Aim: The aim was to assess the impact of introducing a year-long MSK ECHO education programme in Northern Ireland for general practitioners (GPs).

Design and setting: Monthly sessions were held consisting of teaching and case based discussions. Each session lasted on average 90 minutes. A ‘hub’ …

Inhibiting Surface Flashover In Vacuum With High Gradient Insulators, Cameron Harjes

Electrical and Computer Engineering ETDs

In high voltage systems, insulators may be used to separate conductors and these insulators are typically the limiting factor in the system’s operating voltage. When the voltage between two conductors is too large, the insulators can fail due to surface flashover. As systems become more compact, the threat of failure by insulator flashover increases, making the optimization of insulators a critical task for reliability.

Insulators at a vacuum interface are especially vulnerable to surface flashover. Insulators have been shown to holdoff more voltage in vacuum after being baked to remove imbedded surface gases. Ceramic materials are particularly attractive because, unlike …

The Impact Of An Undergraduate Biology Class On Donor Recruitment At A Hospital-Based Blood Donor Center, Alexis R. Peedin, Yara A. Park, Marshall A. Mazepa, Thomas Neish, Jay S. Raval, R Chad Siniard

Pathology Research and Scholarship

OBJECTIVES: A biology class, BIOL 294H, taught undergraduates about platelet donation while partnering with the University of North Carolina's (UNC's) hospital-based Blood Donation Center to recruit apheresis platelet donors. We identified our platelet donors' demographics and learned how BIOL 294H affected recruitment.

METHODS: Every platelet donor presenting to the UNC Blood Donation Center from February 7, 2017, to March 10, 2017, was asked to complete an electronic 10-question survey.

RESULTS: A total of 159 unique donors completed the survey; 64% were female and 75% were between ages 18 and 25 years. Overall, 70% were UNC undergraduate students. Over half (56%) …

02-11-2020 Hsc Committee Agenda (Revised), Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Full Issue

Neutrosophic Sets and Systems

No abstract provided.

20200204_Hslic Welcomes David Lucero, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

2020-02-04 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200203_Hslic's Biomedical Informatics Seminar Series Presents Gary Iwamoto, Md, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

Recommendations For Clinical Laboratory Testing For Protein C Deficiency, For The Subcommittee On Plasma Coagulation Inhibitors Of The Isth, Peter C. Cooper, Anna Pavlova, Gary W. Moore, Kieron P. Hickey, Richard A. Marlar

Pathology Research and Scholarship

Inherited protein C (PC) deficiency increases risk of venous thromboembolism (VTE) by 5 to 10-fold in thrombosis-prone families; however, heterozygous PC deficiency alone does not determine that a subject has thrombophilia. Protein C deficient subjects, who lack additional inherited risk factors such as factor V Leiden or have no major acquired risk factors, may not suffer from VTE. In addition, PC deficiency may be acquired, often due to vitamin K antagonist treatment or liver disease. In contrast, homozygous or compound heterozygous PC deficiencies are rare and serious disorders, and affected infants are often in families with no history of PC …

Evaluation Of Commercial Next-Generation Sequencing Bioinformatics Software Solutions, Rama R. Gullapalli

Pathology Research and Scholarship

Next-generation sequencing (NGS) diagnostics continue to expand rapidly in clinical medicine. An ever-expanding menu of molecular biomarkers is deemed important for diagnostic, prognostic, and therapeutic assessment in patients. The increasing role of NGS in the clinic is driven mainly by the falling costs of sequencing. However, the data-intensive nature of NGS makes bioinformatic analysis a major challenge to many clinical laboratories. Critically needed NGS bioinformatics personnel are hard to recruit and retain in small- to mid-size clinical laboratories. Also, NGS software often lacks the scalability necessary for expanded clinical laboratory testing volumes. Commercial software solutions aim to bridge the bioinformatics …

Evaluation Of Unm's Parental Leave Policy, Julia Fulghum, Karlyn A. Edwards, Charlie Christian, Steven Verney, Lisa A. Marchiondo, Teagan Mullins

ADVANCE Reports

Experiences with UNM’s parental leave policy C215 have been evaluated using the ADVANCE 2018 Main Campus Faculty Climate Survey, a series of junior faculty interviews, and concerns brought to the ADVANCE leadership. Key findings are:

• Women and STEM faculty are more hesitant to use family-leave policies, and perceive greater disadvantage in using them than men and non-STEM faculty
• Sharing of information about, and implementation of, parental leave varies significantly between units
• The attitude of the department chair and senior faculty strongly influence the experience of faculty who use parental leave
• Appropriately implemented, the parental leave policy contributes to faculty recruitment …

Echo Telementoring For Pain, Palliative Care, And Opioid Management: Progress, Challenges, And Future Goals, Joanna G. Katzman

Project ECHO Bibliography

The article in this issue of Pain Medicine by Flynn et al., “Pain Management Telementoring, Long-term Opioid Prescribing, and Patient-Reported Outcomes,” demonstrates patient-level reductions in opioid doses in patients whose clinicians actively participate in pain telementoring as compared with patients whose clinicians participate in pain telementoring at a low level. These outcome data reflect the growing body of evidence that telementoring may improve opioid prescribing and pain management practices.

Rtk Signaling Requires C3ar1/C5ar1 And Il-6r Joint Signaling To Repress Dominant Pten, Socs1/3 And Phlpp Restraint, Michael G. Strainic, Elliot Pohlmann, Christopher C. Valley, Ajay Sammeta, Wasim Hussain, Diane S. Lidke, M Edward Medof

Pathology Research and Scholarship

How receptor tyrosine kinase (RTK) growth signaling is controlled physiologically is incompletely understood. We have previously provided evidence that the survival and mitotic activities of vascular endothelial cell growth factor receptor-2 (VEGFR2) signaling are dependent on C3a/C5a receptor (C3ar1/C5ar1) and IL-6 receptor (IL-6R)-gp130 joint signaling in a physically interactive platform. Herein, we document that the platelet derived and epidermal growth factor receptors (PDGFR and EGFR) are regulated by the same interconnection and clarify the mechanism underlying the dependence. We show that the joint signaling is required to overcome dominant restraint on RTK function by the combined repression of tonically activated …

Coalition For Prisoners' Rights Newsletter, Vol 45-B, No. [2], Coalition For Prisoners' Rights

Coalition for Prisoners' Rights Newsletters

Solidarity Not Solitary: Contradictions Sharpen

El Número de Menores de Edad Sin Hogar

Mas Aceso a Licencias de Conducir

Striving for Redemption

Some Limits on Solitary Confinement

Multi-Sector General Permit 2019 Annual Reports, National Technology & Engineering Solutions Of Sandia (Permit No. Nmr053122), National Technology & Engineering Solutions Of Sandia, Llc

2015 Multi-Sector General Permit

The Multi-Sector General Permit (MSGP) Annual Reports are submitted to the Environmental Protection Agency (EPA) annually as a requirement of the MSGP. The Reports summarize MSGP compliance activities at Sandia National Laboratories for the previous calendar year. NTESS and DOE, as permittees, submit identical reports under their respective permit numbers.

Multi-Sector General Permit 2019 Annual Reports, Department Of Energy/Sandia Field Office (Permit Number Nmr053114), National Technology & Engineering Solutions Of Sandia, Llc

2015 Multi-Sector General Permit

The Multi-Sector General Permit (MSGP) Annual Reports are submitted to the Environmental Protection Agency (EPA) annually as a requirement of the MSGP. The Reports summarize MSGP compliance activities at Sandia National Laboratories for the previous calendar year. NTESS and DOE, as permittees, submit identical reports under their respective permit numbers.

20200130_Bullet Journaling & Digital Tracking 101 - An Introductory Workshop On Thursday, February 6th, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

Kob-4 Interviews Sonia Gipson Rankin And Joshua Kastenberg On The Use Of The Arnold Tool Is Setting Bail, Sonia M. Gipson Rankin, Joshua Kastenberg, Joy Wang

Faculty Scholarship

“The Arnold instrument is a tool that the judges have at their disposal and what you'll notice from the order that the judge released today is she did use it as a tool and as a recommendation, but what she did take into account was the seriousness of the new criminal charge that has been filed,” said UNM Professor of Law, Sonia Gipson Rankin.

“Let's say that you have a person who's loitering and they're charged with possession of methamphetamine and let's say that they're a methamphetamine addict and they've been arrested and charged five times in misdemeanor court. Under …

A Multicenter Study Of The Revogene C. Difficile System For Detection Of The Toxin B Gene From Unformed Stool Specimens, Michael J. Mashock, Matthew L. Faron, Karen C. Carroll, Christina Dang, Shawna Lewis, Hossein Salimnia, Paul Lephart, Vivian G. Loo, Bryan H. Schmitt, Stephen Young, Blake W. Buchan, Nathan A. Ledeboer

Pathology Research and Scholarship

Clostridioides difficile is the leading cause of diarrhea in hospitalized U.S. patients and results in over 400,000 cases of C. difficile infection per year. C. difficile infections have mortality rates of 6 to 30% and significantly increase health care costs, because of increased length of stay and increased frequency of readmissions due to recurrences. Efforts to reduce the spread of C. difficile in hospitals have led to the development of rapid sensitive diagnostic methods. A multicenter study was performed to establish the performance characteristics of the Revogene C. difficile test (Meridian Bioscience, Cincinnati, OH, USA) for use in detection of …

Need For Palliative Care Education In India: Can Online Palliative Care Education Bridge These Needs?, Naveen Salins

Project ECHO Bibliography

No abstract provided.

University Of New Mexico Board Of Regents Minutes For January 24, 2020, University Of New Mexico Board Of Regents

Board of Regents Meeting Minutes

No abstract provided.

20200124_Things Are Coming Together, Laura J. Hall

HSLIC Blog Post

No abstract provided.

Ipe High Points, The Unm Hsc Inter-Professional Education Team

The IPE Newsletters

Shadowing a Community Health Worker (CHW): Social Determinants of Health

Koab Interviews Joshua Kastenberg About The Impeachment Process (Us Senators Discuss Impartiality During Impeachment Trial), Joshua E. Kastenberg, Patrick Hayes

Faculty Scholarship

UNM law professor Joshua Kastenberg said jurors in the Senate are different than jurors in a traditional courtroom. "Members of the United States Senate have a great deal of immunity while they're working in the scope of their duties," Kastenberg said. "And what I mean by immunity, they're immune from criminal indictments of various natures, immune from civil suits as long as it's within the scope of their duties and so a violation of the oath of office is really going to be addressed by the voters."

Arcing Towards Justice: Dr. King’S 2020 Vision, Sonia Gipson Rankin

Faculty Scholarship

Professor Gipson Rankin discusses the Rev. Dr. Martin Luther King’s journey, the experiences that shaped his worldviews, and how we can use these ideas to create a strong future for everyone. She connects Dr. King’s work to artificial intelligence and equality.

If the media player is not working, go directly to the video on the Sandia National Laboratories Mediasite.

A Randomized Trial Of Erythropoietin For Neuroprotection In Preterm Infants, Sandra E Juul, Bryan A Comstock, Rajan Wadhawan, Dennis E Mayock, Sherry E Courtney, Tonya Robinson, Kaashif A Ahmad, Ellen Bendel-Stenzel, Mariana Baserga, Edmund F Lagamma, L Corbin Downey, Raghavendra Rao, Nancy Fahim, Andrea Lampland, Ivan D Frantz Iii, Janine Y Khan, Michael Weiss, Maureen M Gilmore, Robin K Ohls, Nishant Srinivasan, Jorge E Perez, Victor Mckay, Phuong T Vu, Jean Lowe, Karl Kuban, T Michael O'Shea, Adam L Hartman, Patrick J Heagerty, Penut Trial Consortium

Pediatrics Research and Scholarship

BACKGROUND: High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical models of neonatal brain injury, and phase 2 trials have suggested possible efficacy; however, the benefits and safety of this therapy in extremely preterm infants have not been established.

METHODS: In this multicenter, randomized, double-blind trial of high-dose erythropoietin, we assigned 941 infants who were born at 24 weeks 0 days to 27 weeks 6 days of gestation to receive erythropoietin or placebo within 24 hours after birth. Erythropoietin was administered intravenously at a dose of 1000 U per kilogram of body weight every 48 hours for …

On Possibility Of Binary Companion Of The Sun: A Serendipity Finding And Comparison With Uvs Model Of Solar System, Victor Christianto, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

While we completely understood that a binary dwarf companion of the Sun has not been accepted by majority of astronomers, allow us to present some new arguments, along with our own serendipitous encounter with such a binary companion of the Sun. We hope that the present note will be found useful for further investigations, in relation to Planet Nine and such a dwarf star companion of the Sun (sometimes dubbed as Nemesis). Nonetheless, this article is not an exhaustive review of such dwarf companion star theories.

20200115_Hslic's Biomedical Informatics Seminar Series Presents Marianne Berwick, Phd, Mph, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

Clinical Diagnostics And Treatment Strategies For Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia, Richard C. Harvey, Sarah K. Tasian

Pathology Research and Scholarship

Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like ALL) accounts for 15% to 30% of B-cell acute lymphoblastic leukemia in older children, adolescents, and adults and is associated with high rates of conventional treatment failure and relapse. Current clinical trials are assessing the efficacy of the addition of tyrosine kinase inhibitors (TKIs) to chemotherapy for children and adults with Ph-like ALL harboring ABL class translocations or CRLF2 rearrangements and other JAK pathway alterations. However, real-time diagnosis of patients can be quite challenging given the genetic heterogeneity of this disease and the often cytogenetically cryptic nature of Ph-like ALL-associated alterations. In this …