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Volume 51 Masthead, New Mexico Law Review

NMLR Mastheads

No abstract provided.

University Of New Mexico Anti-Racism Action Plan 2021, University Of New Mexico Division Of Equity And Inclusion

Black History at UNM

UNM antiracism action plan 2021: List of initiatives at UNM to intentionally, methodically and systemically address inclusion and equity through an anti-racist lens. This document delineates some recent and planned actions that address concerns raised in calls for action, stimulated by the death of George Floyd. DEI’s work that responds to the many demands for action is ongoing; it is not reactive.

Unnecessary Burdens To Post-Conviction Dna Testing: New Mexico's Post-Conviction Dna Relief Statute And Suggestions For Improvement, Samantha Catalano

Student Published Scholarship

Post-conviction DNA testing is often the last option a convicted person may have to establish that they are not guilty of a crime. New Mexico's post-conviction DNA statute requires convicted persons who seek DNA testing to claim innocence and establish that the identity of the perpetrator was an issue at trial. These requirements are currently included in many state post-conviction DNA statutes; however, some states have amended their statutes to remove these unnecessary requirements. Convicted persons who claimed self-defense, or another affirmative defense may be denied post-conviction DNA testing because of inability to claim "innocence" and because the identity of …

Issues Of Diversity And Inclusion In Torts Cases, Carol M. Suzuki

Faculty Book Display Case

Drawing upon the experience of faculty from across the country, Integrating Doctrine and Diversity is a collection of essays with practical advice, written by faculty for faculty, on specific ways to integrate diversity, equity and inclusion into the law school curriculum. Chapters will focus on subjects traditionally taught in the first-year curriculum (Civil Procedure, Constitutional Law, Contracts, Legal Writing, Legal Research, Property, Torts) and each chapter will also include a short annotated bibliography curated by a law librarian. With submissions from over 40 scholars, the collection is the first of its kind to offer reflections, advice and specific instruction on …

Placental Transfusion And Short-Term Outcomes Among Extremely Preterm Infants, Neha Kumbhat, Barry Eggleston, Alexis S Davis, Krisa P Van Meurs, Sara Bonamo Demauro, Elizabeth E Foglia, Satyanarayan Lakshminrusimha, Michele C Walsh, Kristi L Watterberg, Myra H Wyckoff, Abhik Das, Sara C Handley

Pediatrics Research and Scholarship

OBJECTIVE: To compare short-term outcomes after placental transfusion (delayed cord clamping (DCC) or umbilical cord milking (UCM)) versus immediate cord clamping among extremely preterm infants.

DESIGN: Retrospective study.

SETTING: The

PATIENTS: Infants born <29 >weeks' gestation in 2016 or 2017 without congenital anomalies who received active treatment after delivery.

INTERVENTION/EXPOSURE: DCC or UCM.

MAIN OUTCOME MEASURES: Primary outcomes: (1) composite of mortality or major morbidity by 36 weeks' postmenstrual age (PMA); (2) mortality by 36 weeks PMA and (3) composite of major morbidities by 36 weeks' PMA. Secondary composite outcomes: (1) any grade intraventricular haemorrhage or mortality by 36 weeks' PMA …

Drug Repurposing For Targeting Cyclic Nucleotide Transporters In Acute Leukemias - A Missed Opportunity, Dominique R. Perez, Larry A. Sklar, Alexandre Chigaev, Ksenia Matlawska-Wasowska

Pediatrics Research and Scholarship

While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell differentiation, cell survival, and apoptotic signaling, modulation of the cyclic AMP (cAMP) pathway has provided a meaningful target in hematological malignancies. Several studies have demonstrated that gene expression profiles associated with increased pro-survival cAMP activity or downregulation of various pro-apoptotic factors associated with the cAMP pathway are apparent in acute leukemia patients. Previous work to increase leukemia cell intracellular cAMP focused on the use of cAMP analogs, stimulating cAMP production via transmembrane-associated adenylyl cyclases, or decreasing cAMP …

Neuro Life Online®, Andrea Merriam

Brain & Behavioral Health Research Day

Neuro Life Online® is an online platform delivering live-stream social and educational programs to the movement disorder community via Zoom video conferencing.

In 2016, PMDAlliance began testing Neuro Life Online® (NLO) as a pilot initiative to expand Parkinson’s disease education services in rural/underserved areas. NLO offers live-stream physician-based education, wellness coaching, social opportunities, and assistance in setting up telemedicine services for unserved and underserved populations across the US and internationally.

The need for more services is obvious. 19% of people in the US (60 million people) and 45% worldwide live in rural areas, based on a 2007 UN report. A …

Bacteriophage Virus-Like Particle Based Vaccines Targeting Opioids, Isabella Murphy, Susan Core, Andzoa Jamus, Bryce Chackerian, Kathryn M. Frietze

Brain & Behavioral Health Research Day

Opioid use disorder (OUD) and opioid overdose are growing problems. Opioid vaccines are a novel treatment approach for OUD, but current vaccine strategies are slow to elicit antibodies and require multiple immunizations. Here, we report our efforts to engineer opioid vaccines that could elicit high-titer, long-lasting antibodies with a single dose. We used bacteriophage Q beta virus-like particles (VLPs) as a platform to display oxycodone in a highly immunogenic format. Opioid drugs of interest were chemically modified to include a short peptide linker (G-G-G- G-C). This allowed for the chemical conjugation of the opioid drugs to the surface of the …

Targeted Measures To Enhance Research Conduct During The Covid-19 Pandemic In The Field Of Brain And Behavioral Health, L Stacy, D Rodriguez, L Enriquez-Marquez, R Rai, S Chambers, S Ruyak, L N. Bakhireva

Brain & Behavioral Health Research Day

Background: The COVID-19 pandemic brought two months of campus-wide limited operations at UNM, which resulted in restricted access to clinic populations, limiting in-person study recruitment and assessment opportunities. This presentation highlights the innovative measures taken by the UNM College of Pharmacy’s Substance Use Research and Education (SURE) Center in response to pandemic-induced constrains to ensure continuous enrollment and data collection in ongoing studies.

Methods: Research activities were maintained remotely through novel implementation of several technologies. To recruit participants remotely, a study coordinator contacts providers with the names of potentially eligible patients, after which a contact form is submitted via REDCap …

Medial Prefrontal Cortical Projections Are Altered By A Single Acute Fear Experience: Evidence For Biological Mechanisms Of Anxiety And Substance Abuse Disorders, E L. Bearer, Taylor Uselman, Christopher M. Medina, Russell E. Jacobs

Brain & Behavioral Health Research Day

Pyramidal neurons from medial prefrontal cortex (mPFC) project into striatum, thalamus, hypothalamus, and went as far as dorsal raphe nucleus (midbrain) and locus coeruleus (pons). Neural activity in mPFC is reciprocally modulated by monoamine systems arising in these distant brain regions: noradrenergic, dopaminergic and serotonergic. By deregulating these systems genetically, we previously reported that functional projections from mPFC are similarly regulated by these monoaminergic systems using brain-wide tracing based on manganese-enhanced magentic resonance imaging (MEMRI) followed by statistical parametric mapping (SPM). Here we report that a single experience of acute threat alters mPFC projections in wild type mice, and this …

Effects Of Moderate Prenatal Alcohol Exposure On Nmdars Expression And Functionality In Orbitofrontal Cortex Pyramidal Neurons, Valentina Licheri, Jayapriya Chandrasekaran, Clark W. Bird, Carlos F. Valenzuela, Jonathan L. Brigman

Brain & Behavioral Health Research Day

Alcohol consumption during pregnancy represents a major public health problem. Prenatal alcohol exposure (PAE) disrupts the Central Nervous System (CNS) development inducing long lasting behavioral and cognitive alterations collectively known as Fetal Alcohol Spectrum Disorders (FASDs). It is well established that alcohol affects different cellular targets, but the molecular mechanisms underlying these problems are not still understood. Our previous data reported a significant impairment in orbitofrontal cortex (OFC)-mediated reversal learning (Marquardt et al., 2014b), and an altered firing of OFC pyramidal neurons (Marquardt et al., 2020). Considering that N-Methyl-D-Aspartate receptors (NMDARs) are altered in rodent models after prenatal alcohol exposure …

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2021, Michael Haederle, Sara Mota, Jana Fothergill, Cindy Foster, Rebecca Roybal Jones, Michele Sequeira, Seth Fuller

Research Annual Reports

No abstract provided.

Pt181-Qß Vlp-Based Vaccine Against Tau Pathology Shows Robust Immune Response And Functional Efficacy In The P301s Mouse Model Of Tauopathy, Nicole Maphis, Julianne Peabody, Shanya Jiang, Yirong Yang, D N. Linsenbardt, David S. Peabody, Bryce Chackerian, Kiran Bhaskar

Brain & Behavioral Health Research Day

Background:

Tauopathies are progressive neurodegenerative disorders characterized by the hyperphosphorylation of tau and development of intracellular neurofibrillary tangles, collectively referred to as pathological tau (pTau). It is becoming increasingly recognized that the development and spread of pTau accurately predicts and correlates with clinical progression in human tauopathy patients, however there are no FDA-approved drugs that target and reduce pTau. Previously, our lab has developed a virus-like particle (VLP)-based vaccine using a Qß (RNA bacteriophage) platform to multivalently display a 13-mer pTau peptide, with phospho-Thr181 (pT181, a well-established CSF biomarker for tauopathies). pT181-Qß generates a robust and targeted immune response against …

A Distinctive Approach To Venous Thromboembolism Treatment In A Pediatric, Hemodialysis Patient: A Case Report, Jason Koury, Cintia Schnakenberg, Charlotte Villasenor, Shirley M. Abraham

Pediatrics Research and Scholarship

Enoxaparin is a low molecular weight heparin (LMWH) that is the mainstay for treatment of pediatric patients with a venous thromboembolism, which provides better compliance compared with the use of unfractionated heparin (UFH) in long-term anticoagulation. Although data are limited in pediatric patients with renal insufficiency, enoxaparin can be used in this population. Data related to its use in hemodialysis (HD) pediatric patients is almost non-existent. A major concern for enoxaparin use in patients with renal insufficiency or for those on HD is bleeding. A few studies in adults showed an increased risk of bleeding, but the risk was similar …

Site-Level Variation In The Characteristics And Care Of Infants With Neonatal Opioid Withdrawal, Leslie W. Young, Zhuopei Hu, Robert D. Annett, Abhik Das, Janell F. Fuller, Rosemary D. Higgins, Barry M. Lester, Stephanie L. Merhar, Alan E. Simon, Songthip Ounpraseuth, P Brian Smith, Margaret M. Crawford, Andrew M. Atz, Lesley E. Cottrell, Adam J. Czynski, Sarah Newman, David A. Paul, Pablo J. Sánchez, Erin O. Semmens, M Cody Smith, Christine B. Turley, Bonny L. Whalen, Brenda B. Poindexter, Jessica N. Snowden, Lori A. Devlin, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network And The Nih Environmental Influences On Child Health Outcomes (Echo) Program Institutional Development Awards States Pediatric Clinical Trials Network

Pediatrics Research and Scholarship

BACKGROUND AND OBJECTIVES: Variation in pediatric medical care is common and contributes to differences in patient outcomes. Site-to-site variation in the characteristics and care of infants with neonatal opioid withdrawal syndrome (NOWS) has yet to be quantified. Our objective was to describe site-to-site variation in maternal-infant characteristics, infant management, and outcomes for infants with NOWS.

METHODS: Cross-sectional study of 1377 infants born between July 1, 2016, and June 30, 2017, who were ≥36 weeks' gestation, with NOWS (evidence of opioid exposure and NOWS scoring within the first 120 hours of life) born at or transferred to 1 of 30 participating …

In-Hospital Postoperative Mortality Rates For Selected Procedures In Tanzania's Lake Zone., Taylor Wurdeman, Christopher Strader, Shehnaz Alidina, David Barash, Isabelle Citron, Ntuli Kapologwe, Erastus Maina, Fabian Massaga, Adelina Mazhiqi, John G. Meara, Gopal Menon, Cheri Reynolds, Meaghan Sydlowski, John Varallo, Sarah Maongezi, Mpoki Ulisubisya

Project ECHO Bibliography

BACKGROUND: Postoperative mortality rate is one of six surgical indicators identified by the Lancet Commission on Global Surgery for monitoring access to high-quality surgical care. The primary aim of this study was to measure the postoperative mortality rate in Tanzania's Lake Zone to provide a baseline for surgical strengthening efforts. The secondary aim was to measure the effect of Safe Surgery 2020, a multi-component intervention to improve surgical quality, on postoperative mortality after 10 months.

METHODS: We prospectively collected data on postoperative mortality from 20 health centers, district hospitals, and regional hospitals in Tanzania's Lake Zone over two time periods: …

Medical Nutrition Therapy Access In Ckd: A Cross-Sectional Survey Of Patients And Providers, Elizabeth Yakes Jimenez, Kathryn Kelley, Marsha Schofield, Deborah Brommage, Alison Steiber, Jenica K. Abram, Holly Kramer

Pediatrics Research and Scholarship

RATIONALE & OBJECTIVE: Nutrition management can slow the progression of chronic kidney disease (CKD) and help manage complications of CKD, but few individuals with CKD receive medical nutrition therapy before initiating dialysis. This study aimed to identify knowledge, attitudes, experiences, and practices regarding medical nutrition therapy and barriers and facilitators to medical nutrition therapy access for individuals with CKD stages G1-G5 from the perspective of patients and providers.

STUDY DESIGN: Cross-sectional study composed of anonymous surveys.

SETTING & POPULATION: Adults with CKD stages G1-G5 and medical providers and registered dietitian nutritionists who regularly see patients with CKD stages G1-G5 were …

Capacity Building For A New Multicenter Network Within The Echo Idea States Pediatric Clinical Trials Network, Robert D. Annett, Scott Bickel, John C. Carlson, Kelly Cowan, Sara Cox, Mark J. Fisher, J Dean Jarvis, Alberta S. Kong, Jessica S. Kosut, Kurtis R. Kulbeth, Abbot Laptook, Pearl A. Mcelfish, Mary M. Mcnally, Lee M. Pachter, Barbara A. Pahud, Lee A. Pyles, Jennifer Shaw, Kari Simonsen, Jessica Snowden, Christine B. Turley, Andrew M. Atz

Pediatrics Research and Scholarship

No abstract provided.

Vacteens.Org: A Mobile Web App To Improve Hpv Vaccine Uptake, W Gill Woodall, Gregory Zimet, Alberta Kong, David Buller, Jeannyfer Reither, Lance Chilton, Valerie Myers, Randall Starling

Pediatrics Research and Scholarship

U.S. HPV vaccine uptake remains below the Healthy People 2030 goal of 80% series completion. Parental concerns and misinformation about the efficacy and safety of the Human Papillomavirus (HPV) vaccine remain, and may be addressed by digital interventions tailored to their concerns. Reported here are results from a small scale randomized trial testing a mobile web app for parents and their adolescent daughters (ages 11-14 years) encouraging HPV vaccination in New Mexico, an ethnically-diverse U.S. state.

Metabolic Reprogramming And Cell Adhesion In Acute Leukemia Adaptation To The Cns Niche, Nitesh D. Sharma, Esra'a Keewan, Ksenia Matlawska-Wasowska

Pediatrics Research and Scholarship

Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are associated with a significant risk of short- or long-term toxicities. Leukemic cells can metabolically adapt and survive in the microenvironment of the CNS. The supporting role of the CNS microenvironment in leukemia progression and dissemination has not received sufficient attention. Understanding the mechanism by which leukemic cells survive in the nutrient-poor and oxygen-deprived CNS microenvironment will lead to the development of more specific and less toxic therapies. Here, we review the current literature regarding the roles of metabolic reprogramming …

Spreading Depolarization After Chronic Subdural Hematoma Evacuation: Associated Clinical Risk Factors And Influence On Clinical Outcome, Christine Medows, Herbert Davis, Laila Mohammad, C William Shuttleworth, Michel Torbey, Yiliang Zhu, Ali A. Alsahara, Andrew P. Carlson

Brain & Behavioral Health Research Day

Background: Chronic subdural hematoma (cSDH) is a common neurosurgical condition responsible for excess morbidity, particularly in the geriatric population. Recovery after evacuation is complicated by fluctuating neurological deficits in a high proportion of patients. We previously demonstrated that spreading depolarizations (SD) may be responsible for some of these events. In this study, we aim to determine candidate risk factors for probable SD and assess the influence of probable SD on outcome.

Methods:We used two cohorts who underwent surgery for cSDH. The first cohort (n=40) had electrocorticographic (ECoG) monitoring to detect SD. In the second cohort (n=345), we retrospectively identified …

Issue No. 115: Fall 2021

La Crónica de Nuevo México

2 A Letter From the President

3 Clyde Tingley and the Rerouting of Route 66 by Roger M. Zimmerman

7 Navajo Indian Scouts and Veterans' Pensions by John Lewis Taylor

13 The HSNM Symbols And Capt. Robert Wainwright by John B Ramsay and Michael Stevenson

17 Rudy Laumbach at 90, A Quintessential New Mexican by Doyle Daves

24 Juan Bautista Vigil y Alarid and the Occupation of New Mexico, 1846 by Robert J. Torrez

Physical Activity Newsletter English - Module 2, Unm Prevention Research Center

Module 2 Family Engagement Activities

Physical Activity Newsletter English - Module 2

Unm Pathology Pathfinder Winter 2021, Unm Department Of Pathology

Newsletters

No abstract provided.

Impact Of A Multidisciplinary Workflow On Safety And Management Of Patients With Heparin-Induced Thrombocytopenia, Sheh-Li Chen, Andrew P. Stivers, Jonathan D. Cicci, Tanner L. Hedrick, Marian A. Rollins-Raval, Raj S. Kasthuri, Kalynn A. Northam

Pathology Research and Scholarship

PURPOSE: Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin administration. Management strategies are complex and include discontinuing heparin products, initiating alternative anticoagulants, interpreting laboratory test results, documenting heparin allergies, and providing patient education. Medication error reports and a retrospective review conducted at an academic medical center revealed an opportunity for a quality improvement initiative and led to the creation of a multidisciplinary workflow for the management of HIT. In a pre-post study, the impact of the multidisciplinary workflow on the safety and management of HIT was evaluated.

METHODS: The preimplementation group consisted of adult patients tested for suspected HIT …

Post-Discharge Healthcare Utilization In Infants With Neonatal Opioid Withdrawal Syndrome, Shikhar Shrestha, Melissa H. Roberts, Jessie R. Maxwell, Lawrence M. Leeman, Ludmila N. Bakhireva

Family and Community Medicine Research and Scholarship

The opioid epidemic in the United States has led to a significant increase in the incidence of neonatal opioid withdrawal syndrome (NOWS); however, the understanding of long-term consequences of NOWS is limited. The objective of this study was to evaluate post-discharge healthcare utilization in infants with NOWS and examine the association between NOWS severity and healthcare utilization. A retrospective cohort design was used to ascertain healthcare utilization in the first year after birth-related discharge using the CERNER Health Facts® database. ICD-9/ICD-10 diagnostic codes were used to identify live births and to classify infants into two study groups: NOWS and uncomplicated …

Biomedical Informatics Seminar Series (Biomiss) 2021, Jonathan Eldredge, Gale Hannigan, Tamara Wheeler

Biomedical Informatics Seminar Series (BioMISS)

No abstract provided.

The Role Of Lawyers In Bridging The Gap Between The Robust Federal Rights To Education And Relatively Low Education Outcomes In Guatemala, Maryam Ahranjani

Faculty Scholarship

Relative to other countries in the world and in Central America, the Guatemalan Constitution and the federal education law include a robust and detailed right to education. However, literacy rates and secondary educational attainment, particularly for Indigenous people and young women living in rural communities, remain low. The COVID-19 pandemic has only exacerbated disparities. Once children return to schools after the pandemic, the gaps will be even larger. Lawyers can play a critical role in making the strong Constitutional right to education more meaningful.

Effect Of Dexpramipexole On Neuropathic Pain In Prenatal Alcohol Exposed Male And Female Subjects, Justine Zimmerly, Andrea Pasmay, Shahani Noor, Annette Fernandez, Melody Sun, Suzy Davies, Daniel Savage, Nikolaos Mellios, Erin Milligan

Brain & Behavioral Health Research Day

Prenatal alcohol exposure (PAE) results in chronic central nervous system (CNS) deficits and heightened neuroimmune responses that persist into adulthood. Young adult animals with moderate PAE display pathological sensitivity to light touch, referred to as allodynia, following sciatic nerve chronic constriction injury (CCI). Allodynia coincides with activated spinal glia and an increased presence of peripheral immune cells that invade the CNS. Activated glia and immune cells release the potent pro-inflammatory cytokine, interleukin-1 (IL-1β). Previous studies have shown that dexpramipexole, an enantiomer of pramipexole, reduces caspase-3 and cell death, suggesting a possible anti-inflammatory action. The current study explored whether dexpramipexole is …

Extracellular Asc Level As A Potential Biomarker For Alzheimer’S Disease, Qi "Phoebe" Dong, Shanya Jiang, Kathryn Sanchez, Gary Rosenberg, Kiran Bhaskar

Brain & Behavioral Health Research Day

Purpose:

There is mounting evidence of a link between pathological tau (p-tau) and neuroinflammation in neurodegenerative diseases including Alzheimer’s Disease (AD). In previous studies, we found that p-tau can induce neuroinflammation through activating inflammasomes, a multi-protein complex that recognizes danger signals including bacterial toxins lipopolysaccharide (LPS), nigericin and endogenous danger signals including extracellular ATP and p-tau. Activation of inflammasomes leads to maturation of pro-inflammatory cytokines interleukin-1 (IL)-1b and IL-18, causing neuroinflammation. We aim to obtain quantitative measurements of activated inflammasomes, specifically the levels of assembled ASC (apoptosis-associated speck-like protein containing a CARD), a key adaptor protein of inflammasomes, in the …