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Gradients Of Abandonment, William Tatman Jul 2026

Gradients Of Abandonment, William Tatman

Geography ETDs

As urban-rural disparities drive depopulation in rural areas worldwide, local strategies emerge as pathways for resilience. Research on Ojika, a Japanese island that has lost 75% of its population since the 1960s, reveals an Abandonment Gradient: a nuanced pattern of disuse adapted to modern polycrises. Extending the concept of "lying fallow" to homes and infrastructure, this thesis focuses on abandonment practices that reflect complex realities of labor, capital, and climate uncertainty. Rather than viewing depopulating communities as passive victims of out-migration, this paper argues they are critical sites for generating crisis response. Communally crafted attitudes toward unused space and more-than-human …

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Who Bears The Burden: Tax Incidence And Water Governance In The Middle Rio Grande Conservancy District (Mrgcd) Within Bernalillo County, Michael W. Wilson Jul 2026

Who Bears The Burden: Tax Incidence And Water Governance In The Middle Rio Grande Conservancy District (Mrgcd) Within Bernalillo County, Michael W. Wilson

Economics ETDs

This study examines how property-value-based assessments within a large western irrigation and flood-control district distribute fiscal burdens across property owners. The empirical analysis is restricted to Bernalillo County within the Middle Rio Grande Conservancy District (MRGCD), using parcel-level administrative data from fiscal year 2025 merged with 2021 irrigation service records and geospatial information. The analysis classifies 34,397 parcels by irrigation status, agricultural valuation enrollment, and primary use to evaluate whether non-irrigating residential and commercial parcels, including renter-occupied properties that lack direct irrigation access, bear a disproportionate share of financial responsibility for a district whose first listed priority under their primary …

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The Evolution Of Regulatory Architectures Underlying Phenotypic Plasticity, Shweta Agarwal Jul 2026

The Evolution Of Regulatory Architectures Underlying Phenotypic Plasticity, Shweta Agarwal

Biology ETDs

Phenotypic plasticity refers to a mechanism where a single genotype results in distinct phenotypes in response to distinct environments, making it a key mechanism for persistence under environmental change. Phenotypic plasticity can arise from two distinct regulatory architectures: epistatically regulated plasticity or environmentally sensitive loci. The evolutionary forces shaping these architectures remain unclear. I use the recombination modifier framework to explore how the regulatory architecture of plasticity evolves across a range of selection regimes, including the rate of environmental change and the costs and benefits of plasticity. I find that the evolution of the regulatory architecture of phenotypic plasticity requires …

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Finding Fish Families: Movement And Demography Of Loach Minnow (Tiaroga Cobitis) Inferred From Gt-Seq-Enabled Kinship Analysis, Patrick C. Baca Jul 2026

Finding Fish Families: Movement And Demography Of Loach Minnow (Tiaroga Cobitis) Inferred From Gt-Seq-Enabled Kinship Analysis, Patrick C. Baca

Biology ETDs

River fragmentation poses major threats to freshwater biodiversity by reducing connectivity and limiting persistence of imperiled desert fishes. Connectivity in streams is impaired by anthropogenic changes, including road crossings, prompting the installation of engineered fish passage structures at low-water road crossings and raising questions about the dispersal of aquatic species across these structures. This thesis investigates the movement of the threatened Loach Minnow (Tiaroga cobitis) by applying a close-kin mark-recapture (CKMR) framework in a restored stream (including a fish passage) and a stream without rehabilitation efforts. We developed and optimized a GT-seq panel for relatedness analysis and used it to …

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How To Measure A Carnivore: Understanding The Scaling Of Cranial And Postcranial Elements With Body Mass, Marina Casiano Ruiz Jul 2026

How To Measure A Carnivore: Understanding The Scaling Of Cranial And Postcranial Elements With Body Mass, Marina Casiano Ruiz

Biology ETDs

Body size is a fundamental predictor of ecological function, life history, and population dynamics in mammals. However, direct measurements of body mass remain unavailable for many rare or extinct species, particularly within the order Carnivora. Allometric relationships between skeletal dimensions and body mass provide a tractable solution; however, previous studies have been limited in their taxonomic scope or trait diversity. Here, we quantify the scaling of 82 cranial and postcranial traits across 97 species from 11 carnivoran families spanning four orders of magnitude in body mass (20g to >500kg). Additionally, we examine the influence of phylogenetic relatedness, dietary specialization, and …

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Using Temporal Genomic Data To Uncover Patterns Of Genetic Diversity And Signatures Of Selection For Management Of A Threatened Minnow Species, Erika A. Dunn Jul 2026

Using Temporal Genomic Data To Uncover Patterns Of Genetic Diversity And Signatures Of Selection For Management Of A Threatened Minnow Species, Erika A. Dunn

Biology ETDs

The Little Colorado River (LCR) spinedace persists only in three isolated watersheds within the LCR Basin in Arizona. This imperiled minnow faces ongoing pressure from habitat alteration, climatic shifts, and invasive non-native predators. Over the past two decades, managers have translocated spinedace within watersheds to increase abundance and expand habitat occupancy. We sequenced a reference genome and analyzed single nucleotide polymorphisms (SNPs) from 475 individuals over their geographic range. DNA samples were obtained from a previous study in the mid-1990s and compared with samples from 2024 and 2025, allowing us to track genetic diversity, effective population size, population structure, and …

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West Coast Workshop To Southwest Institute, Hannah Marie Cerne Jul 2026

West Coast Workshop To Southwest Institute, Hannah Marie Cerne

Art & Art History ETDs

This thesis considers Tamarind Institute in Albuquerque, New Mexico (originally established as Tamarind Lithography Workshop in Los Angeles, CA), and its contributions to collaborative printmaking. Originally founded in 1960 by June Wayne with Clinton Adams and Garo Antreasian, Tamarind Lithography Workshop (the precursor to Tamarind Institute) revitalized lithography through structured collaboration between artists and master printers, alongside rigorous training programs. This thesis provides an institutional history of the workshop during its relocation to the University of New Mexico, highlighting its transformation into a university-based institute that integrated education and professional production. Using social and labor-based methodologies, this study analyzes how …

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Investigating Nanoparticle Capture By Condensed Phase Coacervates And Their Mixtures, Sanjna A. Bhakta Jul 2026

Investigating Nanoparticle Capture By Condensed Phase Coacervates And Their Mixtures, Sanjna A. Bhakta

Chemical and Biological Engineering ETDs

The thermoresponsive polymers elastin-like polypeptides (ELPs) and poly(N-isopropylacrylamide) (PNIPAM) have served as a programmable bioseparation tool for applications in nanoparticle capture due to biocompatibility and tunable properties. This work investigates how the polymer composition of ELP and PNIPAM coacervates influences their phase behavior, structural morphology, and nanoparticle recruitment. In addition, the influence of interfacial interactions in nanoparticle recruitment using Tween 80 as a mechanistic probe was also investigated. Different mixtures of ELPs E1.40, E1.80, and E3 with PNIPAM14 and PNIPAM20 were used to characterize their phase behavior and analyze structural morphology using turbidity measurements and microscopy, respectively. Nanobead recruitment using …

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A Contextual And Sonic Analysis Of John Coltrane’S First Meditations, Matt Lind Jul 2026

A Contextual And Sonic Analysis Of John Coltrane’S First Meditations, Matt Lind

Music ETDs

This thesis presents a contextual and sonic analysis of John Coltrane’s album First Meditations recorded in 1965. I use methods based on Dora Hanninen’s A Theory of Music Analysis to examine sonic and contextual aspects of Coltrane’s playing, including varying timbres, rhythmic tendencies, and contextual relationships in musical material. I consider pitch material from the perspective of “outside” playing, rather than traditional harmonic analysis. Considering areas of pitch, rhythm, and timbre allows the visualization of these features across each track in the album in five musical “plots.”

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The Uncertainty Principles, Lee Michael Felicetti Jul 2026

The Uncertainty Principles, Lee Michael Felicetti

Mathematics & Statistics ETDs

The Heisenberg uncertainty principle is a central aspect of quantum mechanics, but also illustrates an essential quality of the Fourier transform. After Heisenberg, a variety of uncertainty inequalities emerged in the fields of physics and mathematics. In this thesis we will analyze the Heisenberg uncertainty principle in both the setting of quantum mechanics and Fourier analysis. We will then look at how the work of Heisenberg has been expanded upon in both physics and mathematics. Particularity, we will see how uncertainty principles can be applied to signal recovery and explore current research in this field.

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Boundary Integral Method For A Modified Mullins–Sekerka System, Ly Le Jul 2026

Boundary Integral Method For A Modified Mullins–Sekerka System, Ly Le

Mathematics & Statistics ETDs

This thesis develops a boundary integral method for a modified Mullins–Sekerka system arising as the sharp-interface limit of a nonreciprocal Cahn–Hilliard model. Nonreciprocal coupling changes the classical Cahn–Hilliard structure by introducing an additional conserved field, leading to coupled elliptic and parabolic dynamics at the interface. Using matched asymptotic expansions, we formally derive the modified Mullins–Sekerka model and then apply the boundary integral method to rewrite it on the moving interface. The elliptic component is represented using the periodic Green’s function for the Laplace equation, while the parabolic component is represented using the periodic heat kernel. This method reduces the bulk …

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Nerve Constructions And Mapper, Alexander Bram Fritschi Jul 2026

Nerve Constructions And Mapper, Alexander Bram Fritschi

Mathematics & Statistics ETDs

Mapper is a data visualization tool commonly used in topological data analysis to study large, often high-dimensional datasets. Mapper operates through the selection of a lens function, a clustering algorithm, and a cover. The Mapper graph is constructed using the nerve of the cover after the clustering algorithm is performed; it is therefore useful to study nerves to better understand Mapper. In this thesis, we will utilize the properties of nerves to find the minimal point set that produces a given graph. We will then extend this to Mapper to determine what Mapper graphs may be constructed over a given …

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Developing Simulation To Improve G3p3 Efficiencies, Andrew Gaudette Jul 2026

Developing Simulation To Improve G3p3 Efficiencies, Andrew Gaudette

Mechanical Engineering ETDs

Concentrated solar power (CSP) systems offer a promising method of renewable energy generation by using heliostats to focus sunlight onto a falling particle receiver. At the National Solar Thermal Testing Facility (NSTTF), particles absorb and store solar energy for later power generation. A major source of efficiency loss is wind-driven particle escape through the receiver aperture. This thesis develops computational fluid dynamics (CFD) simulations to characterize wind flow around the G3P3 falling particle receiver and support future wind mitigation strategies. Numerical studies were conducted to establish an appropriate simulation methodology. Iteration studies showed that 2,000 iterations were sufficient for convergence, …

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Control Of Reshock In A Shock Tube, Alexander Sweis Jul 2026

Control Of Reshock In A Shock Tube, Alexander Sweis

Mechanical Engineering ETDs

Reshocks can pose a threat to the structural integrity of structures and buildings. While incident shock waves pose larger threats, the study of reshocks and reshock attenuation is important to consider. This thesis investigates methods for controlling and attenuating reshock strength within a shock tube through material-based damping and modifications to baffle box geometric configurations. Experiments are performed using a custom-built shock tube in the University of New Mexico fluid mechanics laboratory. Four baffle box configurations are examined: a foam-lined configuration, a foam-lined configuration with ”egg crate-like” textured foam, an empty (no foam) configuration, and a configuration which incorporates a …

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Cbd's Impact On Learning, Memory, And Anxiety: A Dose Response, Audrey Camacho Jul 2026

Cbd's Impact On Learning, Memory, And Anxiety: A Dose Response, Audrey Camacho

Psychology ETDs

Cannabidiol (CBD) is widely utilized for its therapeutic properties, yet its impact on an unmanipulated model at baseline behavior remains poorly understood. This study investigates CBD’s dose-dependent behavioral profile on spatial learning, memory, and anxiety using Long-Evans rats. Subjects received a vehicle, 20 mg/kg, or 40 mg/kg CBD dose prior to assessment in the Morris Water Task (MWT) and Elevated Plus Maze (EPM). MWT results indicated consistent Day 1 learning, but the 40 mg/kg dose induced a temporary disruption 24 hours post-treatment. Performance returned to baseline by day 6. On the EPM, traditional anxiety markers remained unchanged. While CBD did …

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Assessment And Classification Of Idiosyncratic Behavioral Sequences In Rodent Navigation, Max G. Segal Jul 2026

Assessment And Classification Of Idiosyncratic Behavioral Sequences In Rodent Navigation, Max G. Segal

Psychology ETDs

The Morris Water Task (MWT) has been the gold standard assessment of place learning and memory for over four decades, yet the processes that contribute to successful navigation are not completely understood. It is generally posited that rats learn to navigate directly to a place; however, navigation is not perfectly direct but contains variation in swim speed and trajectory resulting in efficient, yet suboptimal paths. Gonçalves-Garcia et al. (2024) demonstrated that path topography is quantitatively similar across trials within individual rats for a given start location, and dissimilar between rats and different start locations within rat. This suggests rats may …

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Elucidation Of Micro/Nanoplastic Signature Of Human And Murine Lung Tissue Utilizing Pyrolysis-Gas Chromatography/Mass Spectrometry, Aerlin D. Decker Jul 2026

Elucidation Of Micro/Nanoplastic Signature Of Human And Murine Lung Tissue Utilizing Pyrolysis-Gas Chromatography/Mass Spectrometry, Aerlin D. Decker

Pharmaceutical Sciences ETDs

Micro-and Nanoplastics (MNPs) are ubiquitous biological pollutants that have been identified throughout a variety of biological samples. MNPs have been detected in several human tissues, such as the brain, kidneys, and liver. Lung tissue remains understudied for MNP accumulation despite the large surface area and clear path for exposure. Using Pyrolysis-Gas Chromatography Mass Spectrometry (Py-GC/MS), human lung tissue was evaluated for 12 different polymers, enabling quantification of total plastic per gram of tissue to be identified. Further analysis was performed with Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to investigate heavy metal accumulation in human lung samples and determine whether a …

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Investigating The Corrosion Behavior Of Stainless Steel 316 In Static Lead Lithium Eutectic Under Applied Stressed Conditions, Daniel E. Levario Jul 2026

Investigating The Corrosion Behavior Of Stainless Steel 316 In Static Lead Lithium Eutectic Under Applied Stressed Conditions, Daniel E. Levario

Nuclear Engineering ETDs

As fusion power moves closer to feasibility, identifying structural materials compatible with breeding blanket environments remains a critical challenge. Lead-lithium eutectic (LLE) is a leading candidate breeder and coolant material due to its low melting point and combined tritium breeding and neutron multiplication capability. However, the corrosive nature of LLE toward structural steels at elevated temperatures must be characterized before these systems can be reliably deployed. This study investigates the corrosion behavior of Type 316 stainless steel in static LLE under applied stress conditions at 550°C using C-ring stress corrosion specimens. Post exposure analysis via optical microscopy, SEM, EDS, and …

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Design And Feasibility Study Of An Air-Cooled Reactor Cavity Cooling System For Fluoride-Salt-Cooled High-Temperature Reactors, Alexandra D. Martinez Jul 2026

Design And Feasibility Study Of An Air-Cooled Reactor Cavity Cooling System For Fluoride-Salt-Cooled High-Temperature Reactors, Alexandra D. Martinez

Nuclear Engineering ETDs

Licensing efforts for Fluoride-Salt-Cooled High-Temperature Reactors (FHRs) are dependent on passive safety systems designed for decay heat removal, yet no prior study has evaluated an air-based Reactor Cavity Cooling System (RCCS) for this role. This thesis addresses that gap by determining whether an air-cooled RCCS can be designed to passively remove post-shutdown decay heat from the Mk 1 FHR. An RCCS configuration was developed and sized using a one-dimensional lumped-parameter design methodology, then evaluated through system-level thermal-hydraulic modeling in RELAP5-3D under a conservative, lower-bound post-shutdown transient. The analysis characterizes the radial heat-transfer pathways from the FHR core to the RCCS …

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Development Of Dynamic Proof-Mass Configurations For Broadband Piezoelectric Energy Harvesting, Nico E. Galarza Jul 2026

Development Of Dynamic Proof-Mass Configurations For Broadband Piezoelectric Energy Harvesting, Nico E. Galarza

Electrical and Computer Engineering ETDs

The purpose of this thesis is to investigate and develop dynamic proof-mass configurations for broadband piezoelectric energy harvesting. Conventional piezoelectric energy harvesters are typically limited by narrow operating bandwidths, restricting their performance under variable-frequency excitation. This research presents the design, fabrication, and experimental evaluation of multiple proof-mass concepts intended to increase the usable frequency range of cantilever-based piezoelectric energy harvesters. Several dynamic mass configurations were developed using additive manufacturing techniques and integrated with commercially available piezoelectric cantilevers. Experimental testing was conducted under controlled vibration conditions to characterize voltage response, resonant behavior, and bandwidth performance. The results demonstrate that dynamic proof-masses …

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Synergizing Crowd Collaboration: Enhancing Crowdsourcing Matching Via Integration Of Matching Theory And Coalition Games, Rowan Aengus Kinney Jul 2026

Synergizing Crowd Collaboration: Enhancing Crowdsourcing Matching Via Integration Of Matching Theory And Coalition Games, Rowan Aengus Kinney

Electrical and Computer Engineering ETDs

This paper tackles the challenges inherent in crowdsourcing dynamics by introducing the CROWDMATCH mechanism. Aimed at enabling crowdworkers to strategically select suitable crowdsourcers while contributing information to crowdsourcing tasks, CROWDMATCH considers incentives, information availability and cost, and the decisions of fellow crowdworkers to model the utility functions for both the crowdworkers and the crowdsourcers. Specifically, the paper presents an initial Approximate CROWDMATCH mechanism grounded in matching theory principles, eliminating externalities from crowdworkers’ decisions and enabling each entity to maximize its utility. Subsequently, the Accurate CROWDMATCH mechanism is introduced, being initiated by the outcome of the Approximate CROWDMATCH mechanism, and employing …

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Making Meaning Of Gendered Experiences: A Mixed Methods Analysis Among U.S. College Students, Andrea Bancroft Jul 2026

Making Meaning Of Gendered Experiences: A Mixed Methods Analysis Among U.S. College Students, Andrea Bancroft

Individual, Family, and Community Education ETDs

Gender inequities rooted in patriarchal norms shape the experiences of college-going emerging adults across many domains, often to the detriment of young women. In this study, we applied a mixed-methods approach to analyzing how college students interpret and make meaning from gendered experiences, and how the meaning making process relates to these emerging adults’ sense of university belonging. Participants provided written narratives of a gendered experience and completed a survey about university belonging. Through our qualitative analyses of the narrative responses, we identified four themes that represent cultural socialization messages that these participants engaged with in their narratives: bioessentialism, expectations …

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Abiquiú And Georgia O’Keeffe Neighbors In A New Mexico Village, Katherine E. Mccully Jul 2026

Abiquiú And Georgia O’Keeffe Neighbors In A New Mexico Village, Katherine E. Mccully

History ETDs

This thesis centers the people of Abiquiú, a small town in northern New Mexico, and discusses their history through the twentieth century into the twenty-first century. I have collected oral histories of Abiqueños, their families, and lives in Abiquiú. More specifically, this thesis explores their experiences of residing with a famous person, artist Georgia O’Keeffe, while maintaining their traditions as a Genízaro village. This thesis is not written solely about O’Keeffe, but, as much as possible, emphasizes the perspectives of the Abiqueños and Abiquiú, while O’Keeffe resided in their community. I seek to write the little-told story of O’Keeffe through …

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Womanhood On The Veranda: Maternalism And The Expansion Of American Women's Public Life, Abigail J. Swanson Jul 2026

Womanhood On The Veranda: Maternalism And The Expansion Of American Women's Public Life, Abigail J. Swanson

History ETDs

Motherhood and child welfare became central organizing principles for reform during the United States Progressive Era.  From these guiding principles, the government formed the United States Children’s Bureau. It was the country's first governmental agency that focused solely on the welfare of children. Mothers writing to the federal government for motherhood advice was a phenomenon that was completely new to twentieth century mothers. Women took pride in their roles as mothers, particularly when it came to child health matters. To the generation of mothers who came before these early twentieth century letter writers, asking the government for advice on child …

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Elucidation Of Spin-Hamiltonian Parameters Via Spectroscopy, Magnetization, And Computation, Joshua C. Mengell Jul 2026

Elucidation Of Spin-Hamiltonian Parameters Via Spectroscopy, Magnetization, And Computation, Joshua C. Mengell

Chemistry and Chemical Biology ETDs

Molecular Quantum Information Science (QIS) is fundamentally concerned with using spin-systems as quantum bits (qubits) or as sensors. Prerequisite to using molecular systems for QIS applications, it must be understood how one can design molecules with bespoke magnetic characteristics. Herein we study various paramagnetic molecular compounds, describing their complex magnetic characteristics using a spin-Hamiltonian formalism. We utilize various (sometimes novel) methods for determining these spin-Hamiltonian parameters. Many of these molecules possess magnetic characteristics, which make them attractive as qubits or for sensing applications. These characteristics include higher total spin-states (qudits—ST>1/2), forbidden interstate electronic transitions, systems of spatially distant …

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Exploring The Nature And Role Of Local Cation Ordering In Disordered Rock Salt Cathodes For Li- And Na-Ion Batteries, You Wang Jul 2026

Exploring The Nature And Role Of Local Cation Ordering In Disordered Rock Salt Cathodes For Li- And Na-Ion Batteries, You Wang

Chemistry and Chemical Biology ETDs

Cation-disordered rock-salt (DRX) cathodes provide a highly tunable platform for next-generation Li- and Na-ion batteries, but their electrochemical behavior is strongly influenced by local structural features hidden in average crystal structures. This dissertation systematically investigates local cation ordering in Li- and Na-based DRX cathodes to understand its effects on Li+/Na+ transport, redox activity, structural evolution, and electrochemical performance. In Li-based systems, Raman spectroscopy and electrochemical analysis reveal that local layered cation ordering in Mn- and Fe-based DRX cathodes is closely correlated with electrochemical behavior. Over-stoichiometric Li-based DRX oxyfluorides further demonstrate that excess Li can regulate local cation ordering, improve Li+ …

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Examining Conditional Indirect Media Effects Through Normative Perceptions: The Role Of Traditional Family Gender Role Expectations And Stigmatizing Beliefs In Human Papillomavirus Vaccination, Moonsun Choi Jul 2026

Examining Conditional Indirect Media Effects Through Normative Perceptions: The Role Of Traditional Family Gender Role Expectations And Stigmatizing Beliefs In Human Papillomavirus Vaccination, Moonsun Choi

Communication ETDs

This dissertation examines how indirect media effects operate through normative perceptions within a gendered and stigmatized health context of HPV vaccination. Specifically, this study investigates how these normative mediation processes are conditioned by traditional family gender role expectations at the norm formation stage and stigmatizing beliefs about HPV vaccination at the normative influence stage. A cross-sectional survey was conducted with mothers of children aged 9 – 12 in the United States in June 2025. The key findings show that while gendered perceptions of HPV vaccination persist, the underlying normative mechanism operated in similar ways across gender-referent contexts. Injunctive norms were …

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Uv Damage Mapping Reveals Different Impacts Of Xpd Mutations On Global Genomic And Transcription-Coupled Dna Repair, Allyson Hoag Jul 2026

Uv Damage Mapping Reveals Different Impacts Of Xpd Mutations On Global Genomic And Transcription-Coupled Dna Repair, Allyson Hoag

Biomedical Sciences ETDs

Nucleotide Excision Repair (NER) is a fundamental cellular process that removes bulky and helical distorting lesions from the genome through the separate responses of its two subpathways – global genomic (GG-NER) and transcription coupled (TC-NER) DNA repair. The pathways converge with the recruitment of the TFIIH complex, a key step that is mediated by the translocase and helicase activities of  its XPD subunit. Germline mutations in XPD result in the clinical disorders, Xeroderma Pigmentosum (XP) and XP combined with Cockayne Syndrome (XP/CS). The goal of this thesis was to understand if XPD XP and XP/CS mutations differentially impact GG-NER and …

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Mapping And Modeling Threat-Evoked Brain States After Early Life Adversity, Taylor W. Uselman Jul 2026

Mapping And Modeling Threat-Evoked Brain States After Early Life Adversity, Taylor W. Uselman

Biomedical Sciences ETDs

Early life adversity (ELA) increases lifelong neuropsychiatric vulnerability. Yet how ELA reorganizes brain-wide activity and circuit coordination across later experience remains unclear. This dissertation tests the hypothesis that ELA alters adult brain-wide activity and responses to threat through disrupted coordination among neural systems that regulate emotional experience, including prefrontal-limbic and monoaminergic systems. Longitudinal manganese-enhanced MRI of adult mice exposed to standard or fragmented early care, combined with computational processing and statistical modeling, quantified brain states before, during, and long after innate predator threat. These studies established that acute threat evokes large-scale, distributed brain activity that evolves over time. ELA potentiates …

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Prenatal Alcohol Exposure Induces Vulnerability To Mild Stress Through Heightened Limbic Glial Activation And Cytokine Release, Justine R. Zimmerly Jul 2026

Prenatal Alcohol Exposure Induces Vulnerability To Mild Stress Through Heightened Limbic Glial Activation And Cytokine Release, Justine R. Zimmerly

Biomedical Sciences ETDs

Fetal alcohol spectrum disorder (FASD) results from prenatal alcohol exposure (PAE) and is linked to development of mood disorders, which in turn are driven by dysregulation of the sympathetic nervous system, the neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis, and the central nervous system (CNS) neuroimmune response to stressors. PAE alters brain glial activation and proinflammatory cytokine expression through secondary challenges such as psychological stressors. The goals of the experiments presented in this dissertation were to 1) examine peripheral glucocorticoid receptor function following mild acute stress in adult PAE offspring, 2) characterize a sensitized cytokine stress response in the hippocampus, medial prefrontal cortex, …

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