Digital Commons Network^™

Above- And Belowground Responses To Environmental Change In The Northern Chihuahuan Desert, Renée Françoise Brown

Biology ETDs

Drylands cover 45% of the terrestrial surface and are expanding rapidly due to anthropogenic drivers. Altered precipitation regimes, atmospheric nitrogen deposition, and wildfire will likely have significant consequences in these regions where ecological processes are limited by water and nitrogen. In this dissertation, I explored temporal dynamics of net primary production (NPP) and related above- and belowground processes under several environmental change drivers in the Sevilleta National Wildlife Refuge, central New Mexico, USA. Located in the northern Chihuahuan Desert, this region experiences strong seasonal precipitation patterns driven by the North American Monsoon, historically characterized by frequent small rain events hypothesized …

Improved Definition Of Nonstandard Neutrosophic Logic And Introduction To Neutrosophic Hyperreals (Fifth Version, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.

Sine Exponential Measure Of Single Valued Neutrosophic Sets In Medical Diagnosis, R. Narmadhagnanam, A. Edward Samue

Neutrosophic Sets and Systems

No abstract provided.

Dna Methylation Testing With S5 For Triage Of High-Risk Hpv Positive Women, Rachael Adcock, Belinda Nedjai, Attila T. Lorincz, Dorota Scibior-Bentkowska, Rawinder Banwait, Norah Torrez-Martinez, Michael Robertson, Jack Cuzick, Cosette M. Wheeler

Pathology Research and Scholarship

Methylation of host and viral genes is promising for triage of women with high-risk human papillomavirus infections (hrHPV). Using a population-based sample of hrHPV positive women with cervical biopsies within 12 months after cervical screening, the clinical value of the S5 methylation classifier (S5), HPV genotyping and cytology were compared as potential triage tests, for outcomes of cervical intraepithelial neoplasia (CIN) grade 3 or greater (CIN3+), CIN2+ and CIN2, and the area under the curve (AUC) calculated. S5 scores increased with histopathology severity (P

Human Herpesvirus 8-Negative Effusion-Based Large B-Cell Lymphoma: A Distinct Entity With Unique Clinicopathologic Characteristics, Savanah D. Gisriel, Ji Yuan, Ryan C. Braunberger, Danielle L V Maracaja, Xueyan Chen, Xiaojun Wu, Jenna Mccracken, Mingyi Chen, Yi Xie, Laura E. Brown, Peng Li, Yi Zhou, Tarsheen Sethi, Austin Mchenry, Ronald G. Hauser, Nathan Paulson, Haiming Tang, Eric D. Hsi, Endi Wang, Qian-Yun Zhang, Ken H. Young, Mina L. Xu, Zenggang Pan

Pathology Research and Scholarship

Rare cases of human herpesvirus 8 (HHV8)-negative effusion-based large B-cell lymphoma (EB-LBCL) occur in body cavities without antecedent or concurrent solid mass formation. In contrast to HHV8 + primary effusion lymphoma (PEL), EB-LBCL has no known association with HIV or HHV8 infection. However, the small sample sizes of case reports and series worldwide, especially from non-Japanese regions, have precluded diagnostic uniformity. Therefore, we conducted a retrospective, multi-institutional study of 55 cases of EB-LBCL and performed a comprehensive review of an additional 147 cases from the literature to identify distinct clinicopathologic characteristics. In our study, EB-LBCL primarily affected elderly (median age …

Percentage Of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy Vs Placebo In The Treatment Of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial, Michael P. Bogenschutz, Stephen Ross, Snehal Bhatt, Tara Baron, Alyssa A. Forcehimes, Eugene Laska, Sarah E. Mennenga, Kelley O'Donnell, Lindsey T. Owens, Samantha Podrebarac, John Rotrosen, J Scott Tonigan, Lindsay Worth

Family and Community Medicine Research and Scholarship

IMPORTANCE: Although classic psychedelic medications have shown promise in the treatment of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown.

OBJECTIVE: To evaluate whether 2 administrations of high-dose psilocybin improve the percentage of heavy drinking days in patients with AUD undergoing psychotherapy relative to outcomes observed with active placebo medication and psychotherapy.

DESIGN, SETTING, AND PARTICIPANTS: In this double-blind randomized clinical trial, participants were offered 12 weeks of manualized psychotherapy and were randomly assigned to receive psilocybin vs diphenhydramine during 2 day-long medication sessions at weeks 4 and 8. Outcomes were assessed over the 32-week double-blind period following …

Logic-Gated Antibody Pairs That Selectively Act On Cells Co-Expressing Two Antigens, Simone C. Oostindie, Derek A. Rinaldi, Gijs G. Zom, Michael J. Wester, Desiree Paulet, Kusai Al-Tamimi, Els Van Der Meijden, Jennifer R. Scheick, Tessa Wilpshaar, Bart De Jong, Marloes Hoff-Van Den Broek, Rachel M. Grattan, Janita J. Oosterhoff, Julie Vignau, Sandra Verploegen, Peter Boross, Frank J. Beurskens, Diane S. Lidke, Janine Schuurman, Rob N. De Jong

Pathology Research and Scholarship

The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect, an approach to enhance the functional selectivity of therapeutic antibodies by making their activity dependent on clustering after binding to two different antigens expressed on the same target cell. lmmunoglobulin G (lgG)-mediated clustering of membrane receptors naturally occurs on cell surfaces to trigger complement- or cell-mediated effector functions or to initiate intracellular signaling. We engineer the Fc domains of two different lgG antibodies to suppress their individual homo-oligomerization while promoting their pairwise hetero-oligomerization …

Interdisciplinary Approaches And Strategies From Research Reproducibility 2020: Educating For Reproducibility, Melissa L. Rethlefsen, Hannah F. Norton, Sarah L. Meyer, Katherine A. Macwilkinson, Plato L. Smith Ii, Hao Ye

Publications

Research Reproducibility: Educating for Reproducibility, Pathways to Research Integrity was an interdisciplinary, conference hosted virtually by the University of Florida in December 2020. This event brought together educators, researchers, students, policy makers, and industry representatives from across the globe to explore best practices, innovations, and new ideas for education around reproducibility and replicability. Emphasizing a broad view of rigor and reproducibility, the conference touched on many aspects of introducing learners to transparency, rigorous study design, data science, data management, replications, and more. Transdisciplinary themes emerged from the panels, keynote, and submitted papers and poster presentations. The identified themes included lifelong …

International Consensus Classification Of Myeloid Neoplasms And Acute Leukemias: Integrating Morphologic, Clinical, And Genomic Data., Daniel A. Arber, Attilio Orazi, Robert P. Hasserjian, Michael J. Borowitz, Katherine R. Calvo, Hans-Michael Kvasnicka, Sa A. Wang, Adam Bagg, Tiziano Barbui, Susan Branford, Carlos E. Bueso-Ramos, Jorge E. Cortes, Paola Dal Cin, Courtney E. Dinardo, Hervé Dombret, Eric J. Duncavage, Benjamin L. Ebert, Elihu H. Estey, Fabio Facchetti, Kathryn Foucar, Naseema Gangat, Umberto Gianelli, Lucy A. Godley, Nicola Gökbuget, Jason Gotlib, Eva Hellström-Lindberg, Gabriela S. Hobbs, Ronald Hoffman, Elias J. Jabbour, Jean-Jacques Kiladjian, Richard A. Larson, Michelle M Le Beau, Mignon L-C Loh, Bob Löwenberg, Elizabeth Macintyre, Luca Malcovati, Charles G. Mullighan, Charlotte Niemeyer, Olatoyosi M. Odenike, Seishi Ogawa, Alberto Orfao, Elli Papaemmanuil, Francesco Passamonti, Kimmo Porkka, Ching-Hon Pui, Jerald P. Radich, Andreas Reiter, Maria Rozman, Martina Rudelius, Michael R. Savona, Annette Schmitt-Graeff, Akiko Shimamura, Jorge Sierra, Wendy A. Stock, Richard M. Stone, Martin S. Tallman, Jürgen Thiele, Hwei-Fang Tien, Alexandar Tzankov, Alessandro M. Vannucchi, Paresh Vyas, Andrew H. Wei, Olga K. Weinberg, Mario Cazzola, Hartmut Döhner, Ayalew Tefferi, Agnieszka Wierzbowska

Pathology Research and Scholarship

The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical advisory committees (CACs) composed of pathologists, hematologists, oncologists, geneticists, and bioinformaticians from around the world. The recent advances in our understanding of the biology of hematologic malignancies, the experience with the use of the 2016 WHO classification in clinical practice, and the results of clinical trials have indicated the need for further revising and updating the classification. As …

Docking Of Syk To Fcεri Is Enhanced By Lyn But Limited In Duration By Ship1, William K. Kanagy, Cédric Cleyrat, Mohamadreza Fazel, Shayna R. Lucero, Marcel P. Bruchez, Keith A. Lidke, Bridget S. Wilson, Diane S. Lidke

Pathology Research and Scholarship

The high-affinity immunoglobulin E (IgE) receptor, FcεRI, is the primary immune receptor found on mast cells and basophils. Signal initiation is classically attributed to phosphorylation of FcεRI β- and γ-subunits by the Src family kinase (SFK) Lyn, followed by the recruitment and activation of the tyrosine kinase Syk. FcεRI signaling is tuned by the balance between Syk-driven positive signaling and the engagement of inhibitory molecules, including SHIP1. Here, we investigate the mechanistic contributions of Lyn, Syk, and SHIP1 to the formation of the FcεRI signalosome. Using Lyn-deficient RBL-2H3 mast cells, we found that another SFK can weakly monophosphorylate the γ-subunit, …

Clinical Practice Guidelines From The Association For The Advancement Of Blood And Biotherapies (Aabb): Covid-19 Convalescent Plasma, Lise J. Estcourt, Claudia S. Cohn, Monica B. Pagano, Claire Iannizzi, Nina Kreuzberger, Nicole Skoetz, Elizabeth S. Allen, Evan M. Bloch, Gregory Beaudoin, Arturo Casadevall, Dana V. Devine, Farid Foroutan, Thomas J. Gniadek, Ruchika Goel, Jed Gorlin, Brenda J. Grossman, Michael J. Joyner, Ryan A. Metcalf, Jay S. Raval, Todd W. Rice, Ralph R. Vassallo, Jeffrey L. Winters, Aaron A R Tobian, Beth H. Shaz

Pathology Research and Scholarship

DESCRIPTION: Coronavirus disease 2019 convalescent plasma (CCP) has emerged as a potential treatment of COVID-19. However, meta-analysis data and recommendations are limited. The Association for the Advancement of Blood and Biotherapies (AABB) developed clinical practice guidelines for the appropriate use of CCP.

METHODS: These guidelines are based on 2 living systematic reviews of randomized controlled trials (RCTs) evaluating CCP from 1 January 2019 to 26 January 2022. There were 33 RCTs assessing 21 916 participants. The results were summarized using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. An expert panel reviewed the data using the GRADE framework …

The Validity Of Mcat Scores In Predicting Students' Performance And Progress In Medical School: Results From A Multisite Study, Joshua T. Hanson, Kevin Busche, Martha L. Elks, Loretta E. Jackson-Williams, Robert A. Liotta, Chad Miller, Cindy A. Morris, Barton Thiessen, Kun Yuan

Pathology Research and Scholarship

PURPOSE: This is the first multisite investigation of the validity of scores from the current version of the Medical College Admission Test (MCAT) in clerkship and licensure contexts. It examined the predictive validity of MCAT scores and undergraduate grade point averages (UGPAs) for performance in preclerkship and clerkship courses and on the United States Medical Licensing Examination Step 1 and Step 2 Clinical Knowledge examinations. It also studied students' progress in medical school.

METHOD: Researchers examined data from 17 U.S. and Canadian MD-granting medical schools for 2016 and 2017 entrants who volunteered for the research and applied with scores from …

The Genomic Landscape Of Pediatric Acute Lymphoblastic Leukemia, Samuel W. Brady, Kathryn G. Roberts, Zhaohui Gu, Lei Shi, Stanley Pounds, Deqing Pei, Cheng Cheng, Yunfeng Dai, Meenakshi Devidas, Chunxu Qu, Ashley N. Hill, Debbie Payne-Turner, Xiaotu Ma, Ilaria Iacobucci, Pradyuamna Baviskar, Lei Wei, Sasi Arunachalam, Kohei Hagiwara, Yanling Liu, Diane A Flasch, Yu Liu, Matthew Parker, Xiaolong Chen, Abdelrahman H. Elsayed, Omkar Pathak, Yongjin Li, Yiping Fan, J Robert Michael, Michael Rusch, Mark R. Wilkinson, Scott Foy, Dale J. Hedges, Scott Newman, Xin Zhou, Jian Wang, Colleen Reilly, Edgar Sioson, Stephen V. Rice, Victor Pastor Loyola, Gang Wu, Evadnie Rampersaud, Shalini C. Reshmi, Julie Gastier-Foster, Jaime M. Guidry Auvil, Patee Gesuwan, Malcolm A. Smith, Naomi Winick, Andrew J. Carroll, Nyla A. Heerema, Richard C. Harvey, Cheryl L. Willman, Eric Larsen, Elizabeth A. Raetz, Michael J. Borowitz, Brent L. Wood, William L. Carroll, Patrick A. Zweidler-Mckay, Karen R. Rabin, Leonard A. Mattano, Kelly W. Maloney, Stuart S. Winter, Michael J. Burke, Wanda Salzer, Kimberly P. Dunsmore, Anne L. Angiolillo, Kristine R. Crews, James R. Downing, Sima Jeha, Ching-Hon Pui, William E. Evans, Jun Yang, Mary V. Relling, Daniela S. Gerhard, Mignon L. Loh, Stephen P. Hunger, Jinghui Zhang, Charles G. Mullighan

Pathology Research and Scholarship

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low mutation burden, ALL cases harbor a median of four putative somatic driver alterations per sample, with 376 putative driver genes identified varying in prevalence across ALL subtypes. Most samples harbor at least one rare gene alteration, including 70 putative cancer driver genes associated with ubiquitination, SUMOylation, noncoding transcripts and other functions. In hyperdiploid B-ALL, chromosomal gains are acquired early and synchronously before ultraviolet-induced mutation. By contrast, ultraviolet-induced mutations precede chromosomal …

Untold Story Of Human Cervical Cancers: Hpv-Negative Cervical Cancer, Jae-Eun Lee, Yein Chung, Siyeon Rhee, Tae-Hyung Kim

Pathology Research and Scholarship

Cervical cancer is the fourth most common malignancy in women worldwide. Although infection from human papillomavirus (HPV) has been the leading cause of cervical cancer, HPV-negative cervical cancer accounts for approximately 3-8% of all cases. Previous research studies on cervical cancer have focused on HPV-positive cervical cancer due to its prevalence, resulting in HPV-negative cervical cancer receiving considerably less attention. As a result, HPV-negative cervical cancer is poorly understood. Its etiology remains elusive mainly due to limitations in research methodology such as lack of defined markers and model systems. Moreover, false HPV negativity can arise from inaccurate diagnostic methods, which …

Ngawbe: Tradición Y Cambio Entre Los Guaymí Del Occidente De Panamá, Milton R.A. Machuca-Gálvez, Phil D. Young Phd

University Libraries & Learning Sciences Faculty and Staff Publications

Esta es la traducción al castellano del libro Ngawbe: Tradition and Change among the Western Guaymi of Panama. de Phil D. Young (1936-2013), publicado en 1971 por University of Illinois Press, Chicago (No. 7 de la serie Estudios en antropología).

Consta de un prefacio, nueve capítulos, un apéndice, un glosario y una bibliografía. En el planteamiento del problema el autor escribió: “Este estudio pretende ser principalmente una descripción de mucho de lo que es tradicional en la sociedad guaymí, especialmente en el ámbito de la organización social y económica. Se intenta explicar las complejas interrelaciones entre la economía y la …

20220829_Meet Our Students Monday, Amy Weig-Pickering

HSLIC Blog Post

No abstract provided.

An Application Of Tajfel’S Social Identity Theory To Understand Gamer As A Social Identity Among Saudi College-Level Students, Mohammad M. Assiri

Language, Literacy, and Sociocultural Studies ETDs

Understanding the social identity construction of Saudi college-level students who self-identify as gamers in Saudi Arabia is essential when designing a student-centered education. Although support exists within the literature for exploring what it means to be a gamer from the perspective of gamers, a review of the literature revealed a gap in this regard in the context of Saudi Arabia. Therefore, this grounded theory study explored self-identification as a gamer in Saudi Arabia using Tajfel's (1981) three tenets of self-identification with a group. A social identity framework was used to understand the characteristics of Saudi gamers, their positive or negative …

Foundations Of Intramedullary Femoral Shaft Fracture Fixation: Avoidance, Recognition, And Management Of Common Pitfalls, Christopher Kurnik, Jory Wasserburger, William Curtis, Tyler Chavez

Western Journal of Orthopaedics

Intramedullary nailing is an effective treatment of femoral shaft fractures. However, this procedure has several common complications and technical problems that can interfere with full recovery in some patients. The purpose of this review article is to expand on the literature with the authors’ own experiences to summarize the following common complications of femoral nailing: missed injuries, suboptimal surgical timing, malreduction, reaming errors, implant insertion errors, pain-management problems, and implant removal errors. Strategies are also identified to help avoid and manage these complications.

Reaming Errors In Intramedullary Nailing, Kathryn C. Helmig, Samer Kakish, Thomas A. Decoster

Western Journal of Orthopaedics

Reaming for intramedullary implants has biomechanical and biologic benefits. However, there are multiple potential pitfalls in the reaming process. Common errors in reaming for intramedullary implants include: over-reaming or under-reaming the intramedullary canal, reamer incarceration, using dull or narrow-fluted reamers, and poor technique. Being aware of these potential problems with reaming helps surgeons avoid intraoperative issues altogether or diagnose their causes as they arise, decrease complications, and improve efficiency in the operating room.

Ex Vivo Human Chondrocyte Toxicity After Exposure To Tranexamic Acidexposure Acid, Erika Garbrecht, Benjamin Packard, Nafisa Elghazali, Phuong A.H. Nguyen

Western Journal of Orthopaedics

Background: Tranexamic acid (TXA) reduces blood loss by inhibiting plasminogen and preventing subsequent fibrinolysis (stabilizing fibrin clots). Topical TXA has been suggested for use in unicompartmental joint arthroplasty and other procedures with residual viable cartilage. However, the effects on human cartilage have not been thoroughly investigated. The purpose of this study is to determine the viability of human chondrocytes in the setting of various concentrations of topical TXA. Methods: 24 human osteochondral (OC) plugs were harvested from the knee joint of a human decedent within 36 hours of death. OC plugs underwent two rinses with Dulbecco’s Phosphate-Buffered Saline (DPBS) and …

History Of External Fixation, Thomas A. Decoster

Western Journal of Orthopaedics

No abstract provided.

Front Matter, Arianna Medina

Western Journal of Orthopaedics

No abstract provided.

Risk Factors For Reoperation Following Operative Fixation Of Distal Femur Fractures: A Report Of 73 Consecutive Cases, Aditya Desai, Victoria Oakes, John Pisquiy, Christopher Dodo, Ahmed A. Toreih, Wael Azzam, Amr Abdelgawad, Ahmed M. Thabet

Western Journal of Orthopaedics

Introduction: Various factors including patient demographics, fracture types, and fixation methods can affect the outcomes of distal femur fractures. This study aimed to analyze the risk factors for reoperation after operative fixation of these fractures. Methods: This was an institional review board (IRB) approved retrospective study of extra-articuilar, partial articular, and complete articular distal femur fractures treated with operative fixation at a Level I trauma center between 2008 and 2018. The study included a consecutive series of adult patients operatively treated for a distal femur fracture. The primary outcome was reoperation rate due to infection, non-union, or implant failure. Periprosthetic …

Nursing Burnout During The Covid-19 Pandemic, Noreen Rizvi

Theoretical Foundation in Advanced Practice Nursing

Nursing burnout continues to rise as the COVID-19 pandemic amplifies environmental stressors in the workplace. This paper explores the application of Callista Roy's adaptation model in preventing nursing burnout during the pandemic using four modes of adaptation: rolefunction, interdependence, physiological/physical, and self-concept or group identity. The presented solution to alleviate nursing burnout examines the implementation of Roy's adaptation model through proposed resiliency initiatives, leadership and management modifications, and state legislature regulation. These interventions aim to reduce anxiety, moral distress, and compassion fatigue, along with increasing support for nurses.

Rock Climbing And Conservation In Land Management: Can They Coexist?, Marissa Heller

Geography ETDs

As participation in outdoor recreation is growing in the U.S., a dilemma is presented for conservation planners and land area managers who must manage the increasing demand for recreation while simultaneously working to protect species. Rock climbers and other outdoor recreationalists have asserted that a relationship exists between recreation and the conservation of public lands. However, mounting evidence suggests that rock climbing continues to cause a multitude of negative impacts to ecosystems. Here, I investigate the extent to which land management practices allow for rock climbing and conservation to coexist, and how it is that well developed plans protect ecologically …

Optical And Computational Methods For Detection And Quantification Of Protein-Protein Interactions Using Single-Molecule Localization Microscopy, David James Schodt

Physics & Astronomy ETDs

Interactions between proteins residing on or near the membranes of biological cells trigger many of the signaling cascades that facilitate the transmission of information between the exterior and the interior of the cell. Normal function of these protein-protein interactions (PPIs) is required for the healthy functioning of complex single- and multi-cellular organisms. Abnormalities involving these interactions are implicated in several diseases, such as the progression and treatment resistance of many forms of cancer. Understanding both the normal and abnormal behaviors of these interactions is necessary to improve our understanding of such diseases, which in turn can drive drug development for …

Machine Learning Model Comparison And Arma Simulation Of Exhaled Breath Signals Classifying Covid-19 Patients, Aaron Christopher Segura

Mathematics & Statistics ETDs

This study compared the performance of machine learning models in classifying COVID-19 patients using exhaled breath signals and simulated datasets. Ground truth classification was determined by the gold standard Polymerase Chain Reaction (PCR) test results. A residual bootstrapped method generated the simulated datasets by fitting signal data to Autoregressive Moving Average (ARMA) models. Classification models included neural networks, k-nearest neighbors, naïve Bayes, random forest, and support vector machines. A Recursive Feature Elimination (RFE) study was performed to determine if reducing signal features would improve the classification models performance using Gini Importance scoring for the two classes. The top 25% of …

Design, Microfabrication And Characterization Of Vibrating Mesh Atomizer For Viscous Fluids, Pallavi Sharma

Mechanical Engineering ETDs

This research focuses on a new piezoelectrically driven Micro Electromechanical Systems based vibrating mesh atomizer that generates the pressure differential required for droplet ejection or spray production using frequency resonances in the 100 kHz range. This study involves device construction and experimental characterization to comprehend the device's operation and the influence of various factors on its performance and determine the limitations of a range of working fluids to atomize.

A novel approach to integrating polymer-based micro heaters with a vibrating mesh atomizer as a monolithic component is presented to expand the range of working liquids for the MEMS device. The …

The Return Of “The Research Mentor” Column, Jonathan Eldredge

Publications

No abstract provided.

Modeling And Performance Analysis Of Deb Based Hydrogen Getters, John A. Matteson

Chemical and Biological Engineering ETDs

Hydrogen getter materials are used to irreversibly absorb hydrogen gas in sealed environments. The DEB based getter system, despite finding widespread use in this application, still posses challenges with respect to experimental performance analysis and fundamental understanding of reaction mechanism. The second chapter of this report addresses the experimental challenges of this getter system by demonstrating the utility and experimental strengths of a custom magnetic suspension balance (MSB) based gravimetric sorption system. This apparatus enables performance evaluation in process relevant conditions including dilute mixed gas environments which our results indicate is necessary for accurate performance evaluation of getter systems. Chapter …