Digital Commons Network^™

Closed Neutrosophic Dominating Set In Neutrosophic Graphs, Amir Majeed, Nabeel Arif

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Speech Recognition Algorithm For Speech Under Stress By Machine Learning, D. Nagarajan, S. Broumi, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.

Reading As A Social Practice: Using Retrospective Miscue Analysis To Understand Kichwa-Spanish Bilinguals’ Meaning Construction, Sandra Leonor Cabrera Moreno

Language, Literacy, and Sociocultural Studies ETDs

Meaning construction is a complex concept that encapsulates language and thought as a whole system in which sense and meaning have a unique relationship highly marked by the social and cultural environment of the reader. Hence, Kichwa-Spanish bilinguals’ reading practices in the Southern Andes of Ecuador cannot be discussed as two separate processes but as an integrated structure embedded in a speech community. This perspective of the bilingual mind is founded on Vygotsky’s sociocultural theory of learning in which language is a psychological tool that shapes and is shaped by our modes of thinking. This unification is a complex process …

Inhibition Of Cellular Mek/Erk Signaling Suppresses Murine Papillomavirus Type 1 Replicative Activities And Promotes Tumor Regression, Adrian J. Luna, Jesse M. Young, Rosa T. Sterk, Virginie Bondu, Fred A. Schultz, Donna F. Kusewitt, Huining Kang, Michelle A. Ozbun

Pathology Research and Scholarship

UNLABELLED: Human papillomaviruses (HPVs) are a significant public health concern due to their widespread transmission, morbidity, and oncogenic potential. Despite efficacious vaccines, millions of unvaccinated individuals and those with existing infections will develop HPV-related diseases for the next two decades. The continuing burden of HPV-related diseases is exacerbated by the lack of effective therapies or cures for most infections, highlighting the need to identify and develop antivirals. The experimental murine papillomavirus type 1 (MmuPV1) model provides opportunities to study papillomavirus pathogenesis in cutaneous epithelium, the oral cavity, and the anogenital tract. However, to date the MmuPV1 infection model has not …

The Intersection Of Racism And Ableism In Disability Support Services, Carrie E. Mulderink

Communication ETDs

The websites of disability resource centers at six universities are used in a discourse analysis to forefront ways in which the Whiteness of disability is upheld. The main research question, built using a DisCrit (Disability/Critical Race theory) lens, is: how do the institutional discourses of disability resource centers reproduce or challenge particular identities for college students with disabilities? The research sub-question explored in this dissertation that built off of this wider scope is: how are the politics of intersectionality addressed in such discourses? Then, in the second analysis chapter, two more analytical categories are discussed that were generated from my …

Update On Shoulder Arthroplasties With Emphasis On Imaging, Jennifer S. Weaver, Imran M. Omar, Nicholson S. Chadwick, Joanna L. Shechtel, Jamie M. Elifritz, Christopher L. Shultz, Mihra S. Taljanovic

Radiology Research and Scholarship

Shoulder pain and dysfunction may significantly impact quality of life. If conservative measures fail, advanced disease is frequently treated with shoulder arthroplasty, which is currently the third most common joint replacement surgery following the hip and knee. The main indications for shoulder arthroplasty include primary osteoarthritis, post-traumatic arthritis, inflammatory arthritis, osteonecrosis, proximal humeral fracture sequelae, severely dislocated proximal humeral fractures, and advanced rotator cuff disease. Several types of anatomic arthroplasties are available, such as humeral head resurfacing and hemiarthroplasties, as well as total anatomic arthroplasties. Reverse total shoulder arthroplasties, which reverse the normal ball-and-socket geometry of the shoulder, are also …

College Of Pharmacy Research & Scholarship Day 2023 Booklet, Becky Woloszyn, Jose Rodriguez

Annual Research & Scholarship Day

No abstract provided.

Research At The University Of New Mexico College Of Pharmacy (Unm Cop) - A Five-Year Overview, Rebecca L. Woloszyn, Luke Latterell

Annual Research & Scholarship Day

No abstract provided.

Ecological Impacts Of Invasive Crayfish In A Naïve Riparian System, Gregor L. Hamilton

Biology ETDs

Aquatic and riparian food webs are inextricably linked. In deserts, they provide critical energy subsidies to surrounding terrestrial food webs, but these vital subsidies are not guaranteed; streams in arid lands are especially sensitive to perturbations. In this dissertation, I investigated the role of an oft-cited threat to stream communities in the lower Colorado River basin: non-native crayfish. I contributed to methodologies in passive integrated transponder use and length-weight relationships in crayfish to aid future research. I leveraged stable isotope analysis of δ¹⁵N, δ¹³C, and δ²H to understand crayfish role in the food webs. …

Transcriptional Silencing Of Cdk18 And Its Role In Lung Carcinogenesis Of Brg1-Mutant Lung Cancers, Loryn M. Phillips

Biology ETDs

BRG1 is mutated in 10% of lung cancers, making this mutation clinically relevant. The downstream effects of BRG1 included significantly affecting the cell cycle control and chromosomal replication pathway. CDK18, a cyclin-dependent kinase, was determined to be the gene with significantly decreased expression (p < 0.0001) in the cell cycle control and chromosomal replication pathway. CDK18 is active during the S-phase of the cell cycle and required for genomic stability. Studies were conducted to determine the epigenetic mechanisms that contributed to the repression of CDK18. Histone methylation contributes to the repression of CDK18, and histone deacetylation globally regulates expression of CDK18, while cytosine methylation was found to not contribute to CDK18 expression. Studies were performed to elucidate CDK18 functional role lung carcinogenesis and the genome-wide impact of CDK18 repression. Repression of CDK18 affects cell migration, proliferation, cell-cell signaling, and anchorage-independent growth that contribute to cancer initiation and progression.

Femtotesla Magnetometry And Nanoscale Imaging With Color Centers In Diamond, Yaser Silani

Optical Science and Engineering ETDs

Intriguing photophysical properties of color centers in diamond make them ideal candidates for many applications from imaging and sensing to quantum networking. In the first part of this work, we have studied the silicon vacancy (SiV) centers in diamond for nanoscale imaging applications. We showed that these centers are promising fluorophores for Stimulated Emission Depletion (STED) microscopy, owing to their photostable, near-infrared emission and favorable photophysical properties. In the second part, we built a femtotesla Radio-Frequency (RF) magnetometer based on the diamond nitrogen vacancy (NV) centers and magnetic flux concentrators. We used this sensor to remotely detect Nuclear Quadrupole Resonance …

To Seek Or Not To Seek? An Inquiry Into Feedback-Seeking Behavior Among Non-Clinical Healthcare Workers, Abigail R. Ortiz

Organization, Information and Learning Sciences ETDs

Understanding what motivates non-clinical healthcare workers to seek feedback in the workplace is critical in supporting such behavior within organizations. This study aims to answer the following research question “Why do non-clinical healthcare workers seek feedback in the workplace?” To conduct this study, I analyzed 13 semi-structured interviews with non-clinical healthcare workers. Findings confirmed the presence of four self-motives (self-assessment, self-improvement, self-enhancement, and self-verification). Additionally, study findings highlighted the presence of other-oriented motives, when individuals seek feedback due to their concern or care for others (i.e., patients, teams, and supervisors). The research also illustrated the interplay of self- and other-oriented …

Trait Sadism In Bdsm Practitioners And Non-Practitioners, Marley Russell

Psychology ETDs

Sadism is an elusive construct within psychology. Multiple types are studied without clear psychometric or theoretical distinctions, and operationalizations of these respective sub-constructs lack validity. This study explores the empirical distinction between two sadism types: consensual sexual sadism (i.e. in the context of BDSM) and trait sadism. Trait sadism is widely synonymized with “everyday sadism”, but here conceptualized as a higher-order construct encompassing both everyday and a novel “prosocial sadism”. I develop and pilot the BDSM Identities and Behaviors (BIB) checklist in a sample of BDSM practitioners. I then compare those practitioners to non-practitioners on trait sadism and dark triad …

Ontogeny Of Sleeping Behaviour In Four Solitary Species Of Anolis Lizards, Joseph C. Barnett, Steven Poe

Biology ETDs

Despite the nearly ubiquitous nature of sleep in the animal kingdom, behavioural research on sleep has focused on a few model organisms and widespread behaviours studied in artificial laboratory settings. In this study, we examine the ontogeny of sleeping perch selection in four closely related species of arboreal lizard in situ. The study species each occupy similar habitats and share "solitary" ecology wherein potential lizard competitors are absent, thus providing four partially independent replicates with which to test hypotheses. We find that structural niche, analysed as perch height, varies by age and sex. Males sleep higher than females and adults …

Sample Questions Formulated By Medical Students For Block Assignment, Jonathan Eldredge, Melissa A. Schiff, Jens O. Langsjoen

Publications

Medical students in the Quantitative Medicine Block completed an Evidence Based Practice (EBP) assignment worth 10% of the final Block grade. The question formulation segment was worth 50% of the assignment score. Students received instructions with an designated subject and some parameters for developing their own EBP questions using the rubric. This supplementary material offers some noteworthy formulated student questions.

Evaluation Of The Dynamic Vision Sensor’S Photoreceptor Circuit For Infrared Event-Based Sensing, Zinah M. Alsaad

Electrical and Computer Engineering ETDs

For space surveillance applications, neuromorphic imaging is being studied as it may perform sensing and tracking tasks with less power and downstream datalink demand. The read-out of the event-based camera is made to only be sensitive to changes in the signals it receives from the photodetector, which results in a datastream of events indicating where and when changes in illumination occur. This is in contrast to the conventional framing camera, which produces images by essentially counting the electrons produced by light incident on each pixel’s photodetector. These cameras are commercially available with siliconbased detectors for applications involving visible wavelengths. However, …

B-Cell Monoclonal Antibodies For Management Of Relapse Remitting Multiple Sclerosis: A Cost Effectiveness Analysis, Sarah Glover

Pharmaceutical Sciences ETDs

Multiple sclerosis (MS) is a neurodegenerative disease in which the central nervous system’s myelin sheath is degraded by auto-immune cells. Relapse remitting multiple sclerosis (RRMS) is the most common MS phenotype, accounting for ~85% of new diagnoses. Disease modifying therapies (DMTs) are used in RRMS to reduce the frequency of relapses and prevent disability progression. The present study performed a cost effectiveness analysis of three B-cell depleting monoclonal antibody DMTs: ocrelizumab, ofatumumab and rituximab, in comparison to commonly utilized interferon beta-1a (IFN-B1a). A Markov model was created to determine the impact of selected DMTs on the number of …

Introduction To Neutrosophic Stochastic Processes, Mohammad Bisher Zeina, Yasin Karmouta

Neutrosophic Sets and Systems

No abstract provided.

The Effects Of Unsupervised Bodyweight Interval Training In Adults With Obesity, Gabriella Bellissimo, Fabiano Amorim, Christine Mermier, Ann Gibson, Len Kravitz, Jonathan Little, Flávio De Castro Magalhães, Zachary A. Mang, Quint Berkemeier, Alyssa Bailly, Jonathan Specht, Jessica Smith, Matthew J. Stork, Shandy Simpson, Natalie Robson, Jeremy Ducharme, Kelsey C. Bourbeau, Yu Yu Hsiao

Health, Exercise, and Sports Sciences ETDs

Objective: Bodyweight interval training (BW-IT) using a social media platform may appeal to those who do not wish to exercise in public or do not have access to specialized exercise equipment. We investigated the ability of a 6-week BW-IT program to improve cardiovascular and metabolic markers. Methods: Fourteen adults (30.7 ± 10.3 yrs.) with obesity (body mass index 35.5 ± 5.4 kg/m²) participated. Bi-weekly program progression was applied by increasing the duration of the work intervals to 60s with 60s active recovery. Peak oxygen consumption (V̇O₂peak), isometric muscular strength, body composition, blood pressure (BP), and metabolic …

Assessment Of Psychosocial And Neonatal Risk Factors For Trajectories Of Behavioral Dysregulation Among Young Children From 18 To 72 Months Of Age, Julie A. Hofheimer, Monica Mcgrath, Rashelle Musci, Guojing Wu, Sarah Polk, Courtney K. Blackwell, Annemarie Stroustrup, Robert D. Annett, Judy Aschner, Brian S. Carter, Jennifer Check, Elisabeth Conradt, Lisa A. Croen, Anne L. Dunlop, Amy J Elliott, Andrew Law, Leslie D. Leve, Jenae M. Neiderhiser, T Michael O'Shea, Amy L. Salisbury, Sheela Sathyanarayana, Rachana Singh, Lynne M. Smith, Andréa Aguiar, Jyoti Angal, Hannah Carliner, Cindy Mcevoy, Steven J. Ondersma, Barry Lester, Program Collaborators For Environmental Influences On Child Health Outcomes

Pediatrics Research and Scholarship

IMPORTANCE: Emotional and behavioral dysregulation during early childhood are associated with severe psychiatric, behavioral, and cognitive disorders through adulthood. Identifying the earliest antecedents of persisting emotional and behavioral dysregulation can inform risk detection practices and targeted interventions to promote adaptive developmental trajectories among at-risk children.

OBJECTIVE: To characterize children's emotional and behavioral regulation trajectories and examine risk factors associated with persisting dysregulation across early childhood.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study examined data from 20 United States cohorts participating in Environmental influences on Child Health Outcomes, which included 3934 mother-child pairs (singleton births) from 1990 to 2019. Statistical analysis …

Priorities To Promote Participant Engagement In The Participant Engagement And Cancer Genome Sequencing (Pe-Cgs) Network, Anne Lr Schuster, Norah L. Crossnohere, Melinda Bachini, Cindy K. Blair, John D. Carpten, Elizabeth B. Claus, Graham A. Colditz, Li Ding, Bettina F. Drake, Ryan C. Fields, Katherine A. Janeway, Bethany M. Kwan, Heinz-Josef Lenz, Qin Ma, Shirz I. Mishra, Electra D. Paskett, Timothy R. Rebbeck, Charité Ricker, Mariana C. Stern, Andrew L. Sussman, Jessica C. Tiner, Jeffrey M. Trent, Joel Gw Verhaak, Nikhil Wagle, Cheryl Willman, John Fp Bridges, Participant Engagement And Cancer Genome Sequencing (Pe-Cgs) Network

Pediatrics Research and Scholarship

Background:

Engaging diverse populations in cancer genomics research is of critical importance and is a fundamental goal of the NCI Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network. Established as part of the Cancer Moonshot, PE-CGS is a consortium of stakeholders including clinicians, scientists, genetic counselors, and representatives of potential study participants and their communities. Participant engagement is an ongoing, bidirectional, and mutually beneficial interaction between study participants and researchers. PE-CGS sought to set priorities in participant engagement for conducting the network's research.

Methods:

PE-CGS deliberatively engaged its stakeholders in the following four-phase process to set the network's research priorities …

Genomic Disorders In Ckd Across The Lifespan, Miguel Verbitsky, Sarathbabu Krishnamurthy, Priya Krithivasan, Daniel Hughes, Atlas Khan, Maddalena Marasà, Natalie Vena, Pavan Khosla, Junying Zhang, Tze Y. Lim, Joseph T. Glessner, Chunhua Weng, Ning Shang, Yufeng Shen, George Hripcsak, Hakon Hakonarson, Iuliana Ionita-Laza, Brynn Levy, Eimear E. Kenny, Ruth J F Loos, Krzysztof Kiryluk, Simone Sanna-Cherchi, David R. Crosslin, Susan Furth, Bradley A. Warady, Robert P. Igo, Sudha K. Iyengar, Craig S. Wong, Afshin Parsa, Harold I. Feldman, Ali G. Gharavi

Pediatrics Research and Scholarship

SIGNIFICANCE STATEMENT: Pathogenic structural genetic variants, also known as genomic disorders, have been associated with pediatric CKD. This study extends those results across the lifespan, with genomic disorders enriched in both pediatric and adult patients compared with controls. In the Chronic Renal Insufficiency Cohort study, genomic disorders were also associated with lower serum Mg, lower educational performance, and a higher risk of death. A phenome-wide association study confirmed the link between kidney disease and genomic disorders in an unbiased way. Systematic detection of genomic disorders can provide a molecular diagnosis and refine prediction of risk and prognosis.

BACKGROUND: Genomic disorders …

Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis, Hyeoncheol Kim, Luke B. Villareal, Zhaoli Liu, Mohammad Haneef, Daniel M. Falcon, David R. Martin, Ho-Joon Lee, Michael K. Dame, Durga Attili, Ying Chen, James Varani, Jason R. Spence, Olga Kovbasnjuk, Justin A. Colacino, Costas A. Lyssiotis, Henry C. Lin, Yatrik M. Shah, Xiang Xue

Pathology Research and Scholarship

Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive iron conditions, TFRC is expected to be reduced to lower iron uptake and toxicity. However, the mechanism whereby TFRC expression is maintained at high levels in iron-enriched cancer cells and the contribution of TFRC to cancer development are enigmatic. Here the work shows TFRC is induced by adenomatous polyposis coli (APC) gene loss-driven β-catenin activation in colorectal cancer, whereas TFRC-mediated intratumoral iron accumulation potentiates β-catenin signaling by directly enhancing the activity of tankyrase. Disruption of TFRC leads to a reduction of colonic iron levels and …

Nanoscience & Microsystems Engineering Apr Spring 2023 Self-Study Report & Documents, Unm Academic Program Review

UNM Academic Program Review

Nanoscience and Microsystems Engineering APR self-study report, review team report, response report, and initial action plan for Spring 2023, fulfilling requirements of the Higher Learning Commission.

University College 2023 Apr Self-Study & Documents, Unm Academic Program Review

UNM Academic Program Review

UNM University College APR self-study report and review team report for Spring 2023, fulfilling requirements of the Higher Learning Commission.

University College Apr Spring 2023 Self-Study Report & Documents, Unm Academic Program Review

UNM Academic Program Review

University College APR self-study report, review team report, response report, and initial action plan for Spring 2022, fulfilling requirements of the Higher Learning Commission. UC includes the following: Liberal Arts & Integrative Studies, ROTC, Academic Communities, and Pre-Health Professions.

Nanoscience And Microsystems Engineering 2023 Apr Self-Study & Documents, Unm Academic Program Review

UNM Academic Program Review

UNM Nanoscience & Microsystems Engineering APR self-study report and review team report for Spring 2023, fulfilling requirements of the Higher Learning Commission.

Biochemistry Apr 2023 Self-Study Report & Documents, Unm Academic Program Review

UNM Academic Program Review

Biochemistry APR self-study report, review team report, response report, and initial action plan for Spring 2023, fulfilling requirements of the Higher Learning Commission.

Biochemistry 2023 Apr Self-Study & Documents, Unm Academic Program Review

UNM Academic Program Review

UNM Biochemistry APR self-study report and review team report for Spring 2023, fulfilling requirements of the Higher Learning Commision

Genomic Disorders In Ckd Across The Lifespan, Miguel Verbitsky, Sarathbabu Krishnamurthy, Priya Krithivasan, Daniel Hughes, Atlas Khan, Maddalena Marasà, Natalie Vena, Pavan Khosla, Junying Zhang, Tze Y. Lim, Joseph T. Glessner, Chunhua Weng, Ning Shang, Yufeng Shen, George Hripcsak, Hakon Hakonarson, Iuliana Ionita-Laza, Brynn Levy, Eimear E. Kenny, Ruth Jf Loos, Krzysztof Kiryluk, Simone Sanna-Cherchi, David R. Crosslin, Susan Furth, Bradley A. Warady, Robert P. Igo, Sudha K. Iyengar, Craig S. Wong, Afshin Parsa, Harold I. Feldman, Ali G. Gharavi

Pediatrics Research and Scholarship

SIGNIFICANCE STATEMENT: Pathogenic structural genetic variants, also known as genomic disorders, have been associated with pediatric CKD. This study extends those results across the lifespan, with genomic disorders enriched in both pediatric and adult patients compared with controls. In the Chronic Renal Insufficiency Cohort study, genomic disorders were also associated with lower serum Mg, lower educational performance, and a higher risk of death. A phenome-wide association study confirmed the link between kidney disease and genomic disorders in an unbiased way. Systematic detection of genomic disorders can provide a molecular diagnosis and refine prediction of risk and prognosis.

BACKGROUND: Genomic disorders …