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Submittal Of Mixed Waste Landfill Annual Long-Term Monitoring & Maintenance Report, April 2022-March 2023 For Sandia National Laboratories/New Mexico, Epa Id Number Nm5890110518, June 2023, Sandia National Laboratories/Nm

Facilities-Units

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories /New Mexico (SNL/NM) personnel submitted the Mixed Waste Landfill (MWL) Annual Long-Term Monitoring and Maintenance Report for the April 2022 through March 2023 reporting period to the New Mexico Environment Department (NMED) in accordance with the requirements of Section 4.8.1 of the MWL Long-Term Monitoring and Maintenance Plan (LTMMP). The LTMMP became effective on January 8, 2014.

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The MWL is a 2.6-acre Solid Waste Management Unit (SWMU 76) located in the north-central portion of SNL/NM Technical Area III that has undergone corrective action. As of March 13, …

“Subsistence Is Cultural Survival”: Examining The Legal Framework For The Recognition And Incorporation Of Traditional Cultural Landscapes Within The National Historic Preservation Act, Wesley James Furlong

Tribal Law Journal

Over the past thirty years, Tribes have exercised growing influence in federal land management and permitting decisions, precipitated, in part, by amendments to the National Historic Preservation Act (“NHPA”) and evolving perspectives in cultural resource management and historic preservation. Despite the increased influence Tribes have gained in federal decision-making processes with the NHPA, it is often an ineffective tool to protect tribal cultural resources. Indigenous cultural resources and perspectives on cultural resource stewardship often do not fit easily within the NHPA’s framework. Nevertheless, until federal law is changed to actually protect Indigenous cultural resources, Tribes must operate within this existing …

A Proposal For A Model Indigenous Intellectual Property Protectiontribal Code (Miipptc), Prof. Tomasz G. Smolinski

Tribal Law Journal

The appropriation of Native American cultural and intellectual property has become commonplace in the United States. At the same time, mainstream, Western cultural/intellectual property laws are inadequate to properly protect traditional Indigenous knowledge. To address this problem, scholars have begun to advocate for a three-tiered system, in which, in addition to national and international legal protections, tribal laws would play a fundamental role in the fight against cultural appropriation. Alas, few Native American tribes explicitly address cultural and/or intellectual property rights in any of their legal instruments. This is especially true with respect to intangible intellectual property, such as traditional …

Tribes And H-1bs: Promoting Inclusion Of Tribal Interests In Immigration Policy Through Employment-Based Visas, Alejandro Alvarado

Tribal Law Journal

Tribal law and immigration law provide a comprehensive space, with plenty of crossover issues, for legal practitioners to explore how immigration law may benefit Tribes and Indigenous Peoples. These issues arise from the history of the United States undermining Tribal interests through immigration policy as it created international borders and established citizenship criteria. As a result, Indigenous Peoples have been impacted by U.S. immigration policy with regard to global mobility, family separation, issues related to border security, and economic prosperity. With the continued growth of Tribal economies, U.S. immigration policy risks limiting Tribal interests and welfare by not providing explicit …

Symptom Duration And Resolution With Early Outpatient Treatment Of Convalescent Plasma For Coronavirus Disease 2019: A Randomized Trial, Sheriza N. Baksh, Sonya L. Heath, Yuriko Fukuta, David Shade, Barry Meisenberg, Evan M. Bloch, Aaron A R Tobian, Emily S. Spivak, Bela Patel, Jonathan Gerber, Jay S. Raval, Donald Forthal, James Paxton, Giselle Mosnaim, Shweta Anjan, Janis Blair, Edward Cachay, Judith Currier, Piyali Das, Moises Huaman, Catherine Sutcliffe, Anusha Yarava, Arturo Casadevall, David Sullivan, Daniel Hanley, Kelly A Gebo

Pathology Research and Scholarship

BACKGROUND: Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) reduces hospitalizations among outpatients treated early after symptom onset. It is unknown whether CCP reduces time to symptom resolution among outpatients.

METHODS: We evaluated symptom resolution at day 14 by trial arm using an adjusted subdistribution hazard model, with hospitalization as a competing risk. We also assessed the prevalence of symptom clusters at day 14 between treatments. Clusters were defined based on biologic clustering, impact on ability to work, and an algorithm.

RESULTS: Among 1070 outpatients followed up after transfusion, 381 of 538 (70.8%) receiving CCP and 381 of 532 (71.6%) receiving …

Application Of Biophysical Techniques To Cellular And Molecular Oncology, Diane S. Lidke, Jennifer M. Gillette, Alessandra Cambi

Pathology Research and Scholarship

Dysregulated cellular processes drive malignant transformation, tumor progression, and metastasis, and affect responses to therapies [...].

Multi-Omic Assessment Shows Dysregulation Of Pulmonary And Systemic Immunity To E-Cigarette Exposure, David P. Scieszka, Devon Garland, Russell Hunter, Guy Herbert, Selita Lucas, Yan Jin, Haiwei Gu, Matthew J. Campen, Judy L. Cannon

Pathology Research and Scholarship

Electronic cigarette (Ecig) use has become more common, gaining increasing acceptance as a safer alternative to tobacco smoking. However, the 2019 outbreak of Ecig and Vaping-Associated Lung Injury (EVALI) alerted the community to the potential for incorporation of deleterious ingredients such as vitamin E acetate into products without adequate safety testing. Understanding Ecig induced molecular changes in the lung and systemically can provide a path to safety assessment and protect consumers from unsafe formulations. While vitamin E acetate has been largely removed from commercial and illicit products, many Ecig products contain additives that remain largely uncharacterized. In this study, we …

Library Workers On The Front Lines Of Conspiracy Theories In The Us: One Nationwide Survey, Stephanie Beene, Katie Greer

University Libraries & Learning Sciences Faculty and Staff Publications

Purpose

The purpose of this study was to investigate whether and in what ways library workers in the United States encountered patrons espousing beliefs in conspiracy theories and, if so, to explore the effectiveness of the strategies they used to address information disorder during the interactions.

Design/methodology/approach

The study was designed with an exploratory qualitative approach. Data were collected via an online survey posted to national and state library association listservs, utilizing a self-selected sampling method. Researchers inductively and deductively analyzed results, developing predetermined themes based on the research questions, then iteratively integrating unexpected data during coding.

Findings

A total …

Human Diversity In Molecular Sexual Dimorphism And Gender Disparities In Health, Adam Z. Reynolds

Anthropology ETDs

Although males and females exhibit an extraordinary range of diversity in sexual dimorphism across populations, prior work on the evolution of sexual dimorphism in human physiology and health has focused on ostensibly universal differences that owe to sex chromosomes and steroid hormones. This dissertation argues that sexual dimorphism in humans is not adequately captured by species-wide sex differences in mean trait values, but instead varies greatly as a result of: (i) our ability to adapt physiologically to a broad range of social and physical environments, and (ii) molecular diversity acquired by different populations over the course of their unique evolutionary …

The Relationship Between Adverse Childhood Experiences And Risky Health Behaviors: Avenues For Prevention In New Mexico, Arianna Trott

Individual, Family, and Community Education ETDs

This study was designed to assess if adverse childhood experiences (ACES) predict risky health behaviors in New Mexico. The purpose was to determine if any factors support improved outcomes for people who have experienced ACES in New Mexico. Lastly, the study aimed to identify if urban-rural status impacted outcomes of risky health behaviors related to ACES. This study used data from the 2019 New Mexico Community Survey across twelve counties (N = 853). Multiple logistic regression and hierarchical linear modeling were used to analyze the data. The findings concluded ACES could predict risky health behaviors. Overall, there was a gradated …

Vi Energy-Efficient Memristor-Based Neuromorphic Computing Circuits And Systems For Radiation Detection Applications, Jorge Iván Canales Verdial

Electrical and Computer Engineering ETDs

Radionuclide spectroscopic sensor data is analyzed with minimal power consumption through the use of neuromorphic computing architectures. Memristor crossbars are harnessed as the computational substrate in this non-conventional computing platform and integrated with CMOS-based neurons to mimic the computational dynamics observed in the mammalian brain’s visual cortex. Functional prototypes using spiking sparse locally competitive approximations are presented. The architectures are evaluated for classification accuracy and energy efficiency. The proposed systems achieve a 90% true positive accuracy with a high-resolution detector and 86% with a low-resolution detector.

Mechanisim Of Plasmon-Driven Photochemical Reactions, Hamed Kookhaee

Chemistry and Chemical Biology ETDs

Understanding a photocatalytic reaction condition that selectively leads to a desired product on metal surfaces is a longstanding research problem in heterogeneous catalysis. Here, using plasmon enhanced N-demethylation of methylene blue (MB) as model reaction, we show that high degree of product selectivity can be achieved by switching the mechanism from charge transfer to adsorbate electronic excitation and vice versa using surface ligands. In the presence of cetyl trimethyl ammonium bromide (CTAB) surface ligand on gold nanoparticles, MB is selectively transformed to thionine at 633 nm excitation wavelength that overlaps with the electronic transition of the adsorbate. At resonant excitation …

The Effect Of Shrub Cover On Conifer Water-Use Patterns, Growth, And Response To Climate Change In The Southern Sierra Nevada, Marissa Goodwin

Biology ETDs

As wildfires increase in size and severity, large areas of forest are undergoing substantial increases in shrub cover. In forests where water is the limiting resource, the partitioning of soil water between shrubs and trees may determine how shrubs affect tree growth and water-stress. We analyzed the δ²H and δ¹⁸O values of xylem water for two conifer species (Abies concolor and Pinus jeffreyi) and two shrub species (Arctostaphylos patula and Ceanothus cordulatus) to assess how shrub cover affects the water-uptake patterns of conifers in the southern Sierra Nevada. We found that growing …

Neuroinflammatory And Metabolomic Temporal Dynamics From Inhaled Wildfire Smoke With Attenuation Via Pharmacological Intervention, David Scieszka

Biomedical Sciences ETDs

Wildfire smoke is a global issue affecting nearly all humans on the surface of this Earth. Smoke dispersion from wildfires can span continents and cross oceans with amazing ease. Furthermore, total acres of land burned per year in the United States has roughly doubled since 1980, meaning this issue will persist for an indeterminate amount of time. Exposure to wildfire smoke is hazardous and promotes aging-associated events in the cardiopulmonary systems. Yet long- and short-term effects on the brain remain relatively unknown. From these, it is critically important to understand the neurological impacts from wildfire smoke exposure; to compare these …

3d Printing Of Earthen Materials: Toward The Carbon-Zero Construction, Shiva Bhusal

Civil Engineering ETDs

In recent years, digital manufacturing techniques in the architecture and construction industry have rapidly gained attention, especially with 3D printing, also called additive manufacturing. The use of cement has been common in modern construction and is now being explored for 3D printing. However, due to cement's contribution to approximately 7 percent of global carbon emissions and its high cost, research on sustainable and greener materials has gained attention. Previous studies on alternative construction have examined the mechanical and rheological properties of soil mixes, but not much attention has been given to printability evaluation, shrinkage, and cracking, which can affect the …

Antimicrobial Activity And Mechanism Of Amyloid Proteins And Synthetic Conjugated Polyelectrolytes, Fahimeh Maghsoodi

Nanoscience and Microsystems ETDs

Although the exact cause of Alzheimer’s disease (AD) is still unknown, it is widely considered that the accumulation of amyloid plaques composed of the amyloid-β (Aβ) peptide in the brain is linked to neurodegeneration. Co-localization of viral DNA with Aβ plaques, the association of brain infection and AD, and research indicating the protective effect of Aβ against bacteria and fungi in mice and human cells have led to the hypothesis that Aβ expression and deposition may be central to its function as an antimicrobial peptide (AMP). In my thesis research, we seek to elucidate how Aβ functions as an AMP …

Reconnaissance: Relationship Between Social Presence And Knowledge Construction In Second Life, Leah A. Hardesty

Organization, Information and Learning Sciences ETDs

This qualitative research study explored levels of social presence in Second Life (virtual world) associated with phases of knowledge construction. The study explored images and data collected from users at two discussion-based activities. The findings revealed the three levels of social presence, according to the Interactional Process Model of Social Presence developed by Schultze and Brooks. Social presence established a sense of mutual monitoring of users that increased users’ sense of presence. This made their virtual interactions more real. Various phases of knowledge construction were observed as specified in the Interaction Analysis Model developed by Gunawardena, Lowe and Anderson. Knowledge …

Synthesis, Characterization And Spectroscopic Studies Of Novel Donor-Acceptor Complexes, Shiyue Gao

Chemistry and Chemical Biology ETDs

Square-planar compounds of the (dichalcogenolene)Pt(diimine) series are possess unique photophysical properties that include long-lived excited state lifetimes, which result in their being potential candidates for numerous applications. These applications include solar energy conversion, photocatalysis, nonlinear optics, and photoluminescent probes of biological systems. The most interesting feature of the (dichalcogenolene)Pt(diimine) series of molecules is the bpydichalcogenolene ligand-to-ligand charge transfer (LL’CT) band. To better understand their photoluminescent decay mechanism, and understand their excited dark state properties, we have synthesized and characterized new compounds that include (Thp-bpy)Pt(CAT), (Thp2-bpy)Pt(CAT), (Thp-bpy)Pt(bdt), and (Thp2-bpy)Pt(bdt). Through interpretation of electronic absorption, resonance Raman, XAS, photoluminesce spectroscopy, in addition …

Challenging The "Unexceptional": Marguerite Of Provence, Thirteenth-Century Queenship, And Power, Katie Despeaux

History ETDs

Marguerite of Provence, wife to Saint Louis IX of France, has long been overlooked or negatively characterized by historians. Due to the unique circumstances of her mother-in-law’s political reach and her sister’s role as queen of England, Marguerite was limited by her husband and his court in her access to power. Traditionally understood as a passive queen, Marguerite’s expression of power through motherhood, curated images, and emotional performance can be better understood through Theresa Earenfight’s paradigm of gender and power. In a series of comparisons between Marguerite and her mother-in-law, sister, and Egyptian counterpart during the Seventh Crusade, Marguerite’s role …

Research Priorities For Therapeutic Plasma Exchange In Critically Ill Patients, Sascha David, Lene Russell, Pedro Castro, Andry Van De Louw, Lara Zafrani, Tasneem Pirani, Nathan D. Nielsen, Eric Mariotte, Bruno L. Ferreyro, Jan T. Kielstein, Luca Montini, Anne C. Brignier, Matthias Kochanek, Joan Cid, Chiara Robba, Ignacio Martin-Loeches, Marlies Ostermann, Nicole P. Juffermans

Pathology Research and Scholarship

Therapeutic plasma exchange (TPE) is a therapeutic intervention that separates plasma from blood cells to remove pathological factors or to replenish deficient factors. The use of TPE is increasing over the last decades. However, despite a good theoretical rationale and biological plausibility for TPE as a therapy for numerous diseases or syndromes associated with critical illness, TPE in the intensive care unit (ICU) setting has not been studied extensively. A group of eighteen experts around the globe from different clinical backgrounds used a modified Delphi method to phrase key research questions related to "TPE in the critically ill patient". These …

Telehealth Monitoring For Non-Hospitalized Covid-19 Positive Patients In A Rural Setting, Rebekah Leann French

Doctor of Nursing Practice Scholarly Projects

Purpose

This quality improvement project evaluates the efficacy of an outpatient COVID-19 telehealth monitoring program intended to increase access to care, decrease emergency room/urgent care visits, and hospital admissions among telehealth observed adult patients in a rural area while providing safe home monitoring during acute illness.

Rationale/Background

Prior to COVID-19 pandemic, healthcare systems within the United States encountered several challenges including healthcare inequality and decreased healthcare access, particularly in rural communities. These gaps became more apparent when a novel COVID-19 pandemic emerged straining healthcare systems in the United States and throughout the world. Challenges ranged from overwhelmed emergency room (ER) …

Key Takeaways For Knowledge Expansion Of Early-Career Scientists Conducting Transdisciplinary Research In Energetics And Cancer (Trec): A Report From The Trec Training Workshop 2022, Che-Pei Kung, Meghan B. Skiba, Erika J. Crosby, Jessica Gorzelitz, Mary A. Kennedy, Bethany A. Kerr, Yun Rose Li, Sarah Nash, Melanie Potiaumpai, Amber S. Kleckner, Dara L. James, Michael F. Coleman, Ciaran M. Fairman, Gloria C. Galván, David O. Garcia, Max J. Gordon, Mathilde His, Lyndsey M. Hornbuckle, So-Youn Kim, Tae-Hyung Kim, Amanika Kumar, Mélanie Mahé, Karen K. Mcdonnell, Jade Moore, Sangphil Oh, Xinghui Sun, Melinda L. Irwin

Pathology Research and Scholarship

The overall goal of the annual Transdisciplinary Research in Energetics and Cancer (TREC) Training Workshop is to provide transdisciplinary training for scientists in energetics and cancer and clinical care. The 2022 Workshop included 27 early-to-mid career investigators (trainees) pursuing diverse TREC research areas in basic, clinical, and population sciences. The 2022 trainees participated in a gallery walk, an interactive qualitative program evaluation method, to summarize key takeaways related to program objectives. Writing groups were formed and collaborated on this summary of the 5 key takeaways from the TREC Workshop. The 2022 TREC Workshop provided a targeted and unique networking opportunity …

Heterogeneity Of Treatment Effects Of Hydrocortisone By Risk Of Bronchopulmonary Dysplasia Or Death Among Extremely Preterm Infants In The National Institute Of Child Health And Human Development Neonatal Research Network Trial: A Secondary Analysis Of A Randomized Clinical Trial, Samuel J. Gentle, Matthew A. Rysavy, Lei Li, Matthew M. Laughon, Ravi M. Patel, Erik A. Jensen, Susan Hintz, Namasivayam Ambalavanan, Waldemar A. Carlo, Kristi Watterberg, National Institute Of Child Health And Human Development Neonatal Research Network

Pediatrics Research and Scholarship

IMPORTANCE: Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health and Human Development Neonatal Research Network (NICHD NRN) Hydrocortisone Trial, hydrocortisone neither reduced rates of BPD or death nor increased rates of neurodevelopmental impairment (NDI) or death.

OBJECTIVE: To determine whether estimated risk for grades 2 to 3 BPD or death is associated with the effect of hydrocortisone on the composite outcomes of (1) grades 2 to 3 BPD or death and (2) moderate or severe NDI or death.

DESIGN, SETTING, AND PARTICIPANTS: …

Alveolar Rhabdomyosarcoma Has Superior Response Rates To Vinorelbine Compared To Embryonal Rhabdomyosarcoma In Patients With Relapsed/Refractory Disease: A Meta-Analysis, Wendy Allen-Rhoades, Philip J. Lupo, Michael E. Scheurer, Yueh-Yun Chi, John F. Kuttesch, Rajkumar Venkatramani, William H. Meyer, Leo Mascarenhas

Pediatrics Research and Scholarship

BACKGROUND: Patients with alveolar rhabdomyosarcoma (ARMS) have inferior outcomes compared to patients with embryonal rhabdomyosarcoma (ERMS) and more effective chemotherapy options are needed for these patients. Vinorelbine is a semisynthetic vinca alkaloid that has clinical activity in relapsed rhabdomyosarcoma (RMS) when used alone or in combination with cyclophosphamide.

AIMS: The goal of our study was to evaluate whether RMS histology subtype influences response rate to vinorelbine alone or in combination.

MATERIALS & METHODS: Five Phase 2 trials that enrolled RMS patients were included in the meta-analysis. Two studies evaluated vinorelbine alone, two studies evaluated vinorelbine in combination with low dose …

Examining The Relationship Between Anxiety And Depression Symptoms, Protective Behavioral Strategies And Opioid Use Outcomes, Melissa Rose Hatch

Psychology ETDs

Protective behavioral strategies (PBS), behaviors individuals use to reduce negative consequences of substance use, have been shown to mediate and moderate the relationship between mental health and substance use outcomes. The present study aimed to examine the relationships between anxiety and depression symptoms and opioid PBS on risky opioid use and opioid-related consequences. Participants in this secondary data analysis were non-treatment seeking individuals who reported past-month opioid use (n=257). Structural equation modeling was used to examine 1) PBS as a mediator of the relationship between anxiety/depression symptoms and opioid use outcomes, and 2) anxiety/depression symptoms as a moderator …

A Reconfigurable Architecture For Matrix Multiplication For Low Power Applications, Jeffrey Love

Electrical and Computer Engineering ETDs

This thesis presents a hardware architecture for performing matrix multiplication via a systolic array to reduce time complexity and power consumption. The proposed architecture, the Neural Network Accelerator (NNA), was designed in Verilog HDL to perform 8-bit multiplication to reduce the resources required to implement the NNA on low-power FPGAs. The NNA’s open architecture is designed to support radiation test for fault tolerant designs targeting space applications. Commercial hardware architecture information is not public knowledge, which led us to build our own matrix multiplication architecture so that we could later study its feasibility for space applications.

The NNA was compared …

Multi-Factor Disturbance Regimes Drive Soil Fungal Community Composition Across A Southwestern Us Riparian Cottonwood Landscape, Rich Wagner

Biology ETDs

In southwestern US riparian cottonwood forests, anthropogenic changes have replaced the structuring force of seasonal flooding with novel multi-factor disturbance regimes, driving these ecosystems to new states. While the impetus for restoration is high, little attention has been paid to understanding belowground feedbacks from these new drivers. Using high-throughput sequencing of environmental DNA, we compared the impacts of fires, exotic plants, restoration practices and lower levels of disturbance on soil fungal community composition and diversity across a riparian cottonwood landscape in New Mexico. We focused on mycorrhizal fungi for the benefits they may confer upon cottonwoods. We found that along …

Transcriptional Regulation Of Stem Cell Function In The Drosophila Central Nervous System, Amalia S. Parra

Biology ETDs

Development of multicellular organisms depends on coordination of various molecular mechanisms to ensure proper tissue size and structure. This is accomplished through intrinsic and extrinsic cues that regulate cell growth and proliferation both spatially and temporally. These well-coordinated signals are present from early developmental stages and remain active throughout development to ensure tissue structure is appropriate for function. This is particularly important in early cell types that form specialized lineages such as stem cells or those found throughout the body such as epithelia. While much progress has been made in understanding growth regulatory mechanisms, several fundamental aspects remain unknown. This …

Assessing Verbal Memory Task Performance And Intractable Epilepsy: The Associations Among Hippocampal Volume Ratio, Seizure Demographic Factors And Memory Indices, Alexis Gabrielle Burks

Psychology ETDs

Epilepsy affects 3.4 million people in the United States and may affect their memory performance. This study investigated the relationships between memory performance, hippocampal volume ratio, and demographic factors in adults with intractable epilepsy in standardized memory tasks and an experimental memory task designed to be repeated daily. Participants underwent electrode implantation surgery and completed comprehensive neuropsychological assessments prior to surgery including an experimental memory task during their stay in the hospital. Correlation, ANOVA, and regression analyses were completed. The standardized memory tasks and the experimental memory task were significantly correlated. Hippocampal volume ratio was not significantly correlated to memory …

A Comparative Study Of Fuzzy Cognitive Maps And Neutrosophic Cognitive Maps On Covid Variants, Regan Murugesan, Yamini Parthiban, R. Narmada Devi, Kala Raja Mohan, Sathish Kumar Kumarave

Neutrosophic Sets and Systems

No abstract provided.