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Articles 3271 - 3300 of 10245
Full-Text Articles in Entire DC Network
Cd82 Regulation Of Hematopoietic Stem/Progenitor Cell - Niche Adhesion, Maura L. Cotter
Cd82 Regulation Of Hematopoietic Stem/Progenitor Cell - Niche Adhesion, Maura L. Cotter
Biomedical Sciences ETDs
The spatial organization and dynamics of proteins and lipids within the cell membrane is important for the regulation of cell signaling, adhesion, and cell communication. Within the bone marrow niche, communication between hematopoietic stem/progenitor cells (HSPCs) and niche cells is essential for regulating their proliferation, differentiation, and survival. Our previous work has ascertained that HSPCs utilize a polarized domain on the plasma membrane that serves as the contact site with osteoblasts, which are important members of the bone marrow niche. Using human primary CD34+ stem/progenitor cells and the progenitor-like KG1a cell line, we found this domain to be enriched in …
Exploring The Use Of Synthetic Delivery Platforms And Small Molecule Adjuvants To Improve The Efficacy Of Spinal Interleukin-10 Gene Therapy For Chronic Neuropathic Pain, Ellen C. Dengler
Biomedical Sciences ETDs
The focus of the work in this dissertation is to improve the efficiency of a gene therapy for the treatment of chronic pain. The introduction, Chapter 1, is intended to orient the reader to the underlying physiological principles and anatomical structures involved in general sensory and pain transmission in the peripheral and central nervous systems. Pain modulatory systems are described in detail. Also included is a discussion of how peripheral nerve injury can provoke immune changes at the spinal level, including the activation of spinal macrophages and glial cells (microglia, astrocytes and oligodendrocytes) with the release of immune modulators, such …
From Paper Trails To Dna Barcodes: Enhancing Traceability In Forest And Fishery Certification, Andrea Migone, Michael Howlett
From Paper Trails To Dna Barcodes: Enhancing Traceability In Forest And Fishery Certification, Andrea Migone, Michael Howlett
Natural Resources Journal
No abstract provided.
Decision-Making Triggers, Adaptive Management, And Natural Resources Law And Planning, Courtney Schultz, Martin Nie
Decision-Making Triggers, Adaptive Management, And Natural Resources Law And Planning, Courtney Schultz, Martin Nie
Natural Resources Journal
No abstract provided.
Alternative Income Generating Opportunities: A Case Study In Mezquital, Mexico, Kristen Mattila
Alternative Income Generating Opportunities: A Case Study In Mezquital, Mexico, Kristen Mattila
Latin American Studies ETDs
This thesis is an in-depth exploration of the situation of women in the border town of Mezquital, Mexico. The local experiences of women in Mezquital are situated within the larger theoretical debates of economic policy in Latin America, gender, labor and development. The theoretical analysis sets the stage to facilitate a process aimed at assisting the local women of Mezquital in creating alternative income generating opportunities to meet their specific economic needs and to highlight their talents. A participatory research process was implemented that incorporated the underlying assumptions of the gender and development paradigm. This case study is a snapshot …
Transcending Traditional Approaches To Sexuality Education: A Case Study In Communicating, Constructing, And Defining Sex-Positive Sexuality Education, Jessica A. Nodulman
Transcending Traditional Approaches To Sexuality Education: A Case Study In Communicating, Constructing, And Defining Sex-Positive Sexuality Education, Jessica A. Nodulman
Communication ETDs
Guided by a social-ecological approach to health, this study explored a new approach to sex education--sex-positive sexuality education (SPSE). A collective case study was completed on three organizations that utilize a sex-positive approach to sexuality education--Good Vibrations, Scarleteen.com, and The National Sexuality Resource Center's Summer Institute. Good Vibrations is an adult sex toy retailer, Scarleteen.com is an adolescent sexual health website, and the Summer Institute is an academic institute for scholars and practitioners of sexuality studies. Using qualitative methods of observations, interviews, and textual analysis, this study explains how sex-positive sexuality education is constructed, communicated, and defined. Despite studying three …
Energy Consumption In Networks On Chip : Efficiency And Scaling, George Bezerra
Energy Consumption In Networks On Chip : Efficiency And Scaling, George Bezerra
Computer Science ETDs
Computer architecture design is in a new era where performance is increased by replicating processing cores on a chip rather than making CPUs larger and faster. This design strategy is motivated by the superior energy efficiency of the multi-core architecture compared to the traditional monolithic CPU. If the trend continues as expected, the number of cores on a chip is predicted to grow exponentially over time as the density of transistors on a die increases. A major challenge to the efficiency of multi-core chips is the energy used for communication among cores over a Network on Chip (NoC). As the …
Feeding Ecology And Life History Strategies Of White-Faced Capuchin Monkeys, Elizabeth C. Eadie
Feeding Ecology And Life History Strategies Of White-Faced Capuchin Monkeys, Elizabeth C. Eadie
Anthropology ETDs
Dietary niches have widespread effects on individuals life histories, behaviors, and morphologies. Capuchin monkeys inhabit a complex dietary niche that often entails hunting of relatively large vertebrate prey, tool-use, and extraction of embedded resources that other closely related and sympatric species do not exploit. In this dissertation I examine, a) how juvenile capuchins overcome the challenges of reliance on a difficult-to-acquire diet, b) at what age juveniles achieve maximum foraging return rates for difficult-to-acquire foods, and c) what nutritional benefits capuchins obtain from exploitation of these foods. In the process of addressing these questions I test two prominent hypotheses regarding …
Pollination Ecology Of Agave Palmeri In New Mexico, And Landscape Use Of Leptonycteris Nivalis In Relation To Agaves, Angela E. England
Pollination Ecology Of Agave Palmeri In New Mexico, And Landscape Use Of Leptonycteris Nivalis In Relation To Agaves, Angela E. England
Biology ETDs
Where animals spend time can provide important clues to their ecological needs, but this information is very difficult to obtain for small volant animals. The research described in Chapter 1 was an attempt to discern how L. nivalis utilize the landscape in relation to the distribution of Agave havardiana in Big Bend National Park, Texas. I found that although the landscape use of Leptonycteris nivalis is centered on habitat with high concentrations of blooming A.havardiana, it is not restricted to those areas, and furthermore adults and juveniles may differ in their behavior. Adult females may remain near food sources in …
The Effect Of Increased Growth Temperature On Mid-Day And Mid-Night Co2 Fluxes In Populus Deltoids, Rachel Zulick
The Effect Of Increased Growth Temperature On Mid-Day And Mid-Night Co2 Fluxes In Populus Deltoids, Rachel Zulick
Biology ETDs
As global temperatures rise, understanding the effects of increased temperature on daily carbon dioxide fluxes is necessary to predict changes to the global carbon cycle. Using tunable diode laser spectroscopy, I measured CO2 fluxes and changes in isotopic composition of root respiration, leaf respiration and photosynthesis over a 12-hour night to day transition. I found that after a 10°C increase in growth temperature for four weeks, root CO2 fluxes acclimated to the higher temperature (i.e. they were not significantly different from controls). In contrast, both photosynthesis and respiration of leaves were higher at the elevated growth temperature. Though the root …
2011 Annual Report, Joseph A. Cook
Wednesday Communiqué, 6/20/2012, Chaouki Abdallah
Wednesday Communiqué, 6/20/2012, Chaouki Abdallah
Publications of the Provost's Office
Let us in education dream of an aristocracy of achievement arising out of a democracy of opportunity.' Thomas Jefferson'
Argentina Passes Far-Reaching Gender-Identity, Death-With-Dignity Laws, Andrã©S GaudãN
Argentina Passes Far-Reaching Gender-Identity, Death-With-Dignity Laws, Andrã©S GaudãN
NotiSur
No abstract provided.
June 7, 2012 Finance & Facilities (F&F) Committee Meeting, Evp For Administration
June 7, 2012 Finance & Facilities (F&F) Committee Meeting, Evp For Administration
Finance and Facilities Committee
Documents related to the June 7, 2012 Board of Regents' Finance and Facilities Committee Meeting. (Agenda, Minutes, eBook, Notice)
Vitamin D: Myth Or Magic?, Elizabeth Szalay
Vitamin D: Myth Or Magic?, Elizabeth Szalay
UNM Orthopaedic Research Journal
No abstract provided.
A Brief History Of Medullary Nailing, New Mexico Perspective, Thomas Decoster
A Brief History Of Medullary Nailing, New Mexico Perspective, Thomas Decoster
UNM Orthopaedic Research Journal
No abstract provided.
Gpsa Student Council Meeting, 5/5/2012, Graduate And Professional Student Association
Gpsa Student Council Meeting, 5/5/2012, Graduate And Professional Student Association
GPSA Meeting Agendas and Minutes
No abstract provided.
Variation And Organization In Social Behavior: Infectious Disease And Human Intergroup Conflict And Warfare; And The Organization Of Foraging Behavior In Harvester Ants, Kenneth Letendre
Biology ETDs
Social behavior is an important contributor to the success of widely distributed animal taxa, including such distantly related taxa as humans and ants. There is variation in the features and organization of social systems based on ecological constraints and goals, as these alter the costs and benefits of social behaviors, and select for different optimal behaviors for social groups in different environments. I present two bodies of research: an effort to explain geographic variation in the frequency and intensity of human civil conflict; and an effort to describe and model the foraging behavior of colonies of harvester ants of the …
The Effects Of Precipitation Variability On C4 Photosynthesis, Net Primary Production And Soil Respiration In A Chihuahuan Desert Grassland, Michell L. Thomey
The Effects Of Precipitation Variability On C4 Photosynthesis, Net Primary Production And Soil Respiration In A Chihuahuan Desert Grassland, Michell L. Thomey
Biology ETDs
Although the Earths climate system has always been inherently variable, the magnitude and rate of anthropogenic climate change is subjecting ecosystems and the populations that they contain to novel environmental conditions. Because water is the most limiting resource, arid-semiarid ecosystems are likely to be highly responsive to future climate variability. The goal of my dissertation is to understand how precipitation variability affects primary productivity and soil respiration in desert grassland ecosystems. Initially, I reviewed the literature to understand how climate change affects net ecosystem exchange (NEE) across the warm deserts of North America (Chapter 2). Next, I examined the effects …
Lymphocyte Evolution And Ontogeny In Non-Eutherian Mammals, Xinxin Wang
Lymphocyte Evolution And Ontogeny In Non-Eutherian Mammals, Xinxin Wang
Biology ETDs
Based on their different reproductive modes and evolutionary history, extant mammals are divided into three lineages: eutherians, marsupials and monotremes. Marsupials are the closest relatives to eutherians. They are born immune-incompetent. The characteristic that they develop their immune system postnatally makes them unique models to study newborn immune development and maternal immunology. As monotremes comprises the basal lineage of mammals, the study of monotreme immunology will provide unique insights regarding the origin of the mammalian immune system. Unfortunately, compared to our in-depth knowledge of eutherian immunology, especially humans and mice, knowledge of marsupial and monotreme immunology is scarce. The goal …
Functions Of Autophagy In Lipid Homeostasis And Survival In Androgen-Dependent Prostate Cancer Cells, Ramesh Raj Kaini
Functions Of Autophagy In Lipid Homeostasis And Survival In Androgen-Dependent Prostate Cancer Cells, Ramesh Raj Kaini
Biomedical Sciences ETDs
Androgen deprivation therapy, one of the standard treatments for prostate cancer, induces apoptosis as well as autophagy in androgen-responsive PCa cells. As modulation of autophagy is a new paradigm for enhancing the therapeutic efficacy of various cancer therapies, we sought to determine the functions of autophagy during androgen deprivation. In this study, we confirmed that androgen removal or inhibition induces autophagy in two different hormone sensitive prostate cancer cells. Androgen deprivation also caused depletion of lipid droplets which was abrogated on inhibition of autophagy by pharmacological means (3-methyladenine, bafilomycin A1) or using a genetic approach (Atg5 siRNA). In addition, colocalization …
Novel Mechanisms Of Androgen Receptor Degradation By Alpha-Tocopherylquinone And Curcumin Analog 27, Alexandra Marie Fajardo
Novel Mechanisms Of Androgen Receptor Degradation By Alpha-Tocopherylquinone And Curcumin Analog 27, Alexandra Marie Fajardo
Biomedical Sciences ETDs
Defining underlying molecular mechanisms exploited by cancer cells in their development and progression provides a necessary foundation for experimental therapeutics. The androgen receptor (AR) is a known therapeutic target for prostate cancer (CaP) given its well-established role in both the development and progression of CaP. The AR is a ligand activated transcription factor that regulates the expression of many genes involved in proliferation and differentiation. Identifying agents that down-regulate AR expression may elucidate mechanism(s) for selectively targeting the AR. Two related agents of the natural products curcumin and vitamin E, curcumin analog 27 (ca27) and alpha-tocopheryl quinone (TQ), respectively were …
Population Dynamics Of Flaviviruses In The United States, Kendra Pesko
Population Dynamics Of Flaviviruses In The United States, Kendra Pesko
Biomedical Sciences ETDs
The genus Flavivirus comprises viral species with positive sense, single stranded RNA genomes, most of which are transmitted by mosquitoes and ticks. During replication, RNA viruses have higher mutation rates than DNA viruses, because their virally encoded RNA dependent RNA polymerase has no proofreading activity. These viruses have been shown to exist within and between hosts as swarms of closely related mutant genomes that can be examined through sequence analysis. In the work presented here we focus on the population dynamics of two zoonotic flaviviruses that cause human morbidity and mortality in the United States: tick-borne Powassan virus (POW) and …
Multifunctional Iron Platinum Stealth Immunomicelles: Targeted Imaging And Therapy Of Prostate Cancer, Robert M. Taylor
Multifunctional Iron Platinum Stealth Immunomicelles: Targeted Imaging And Therapy Of Prostate Cancer, Robert M. Taylor
Biomedical Sciences ETDs
In the United States, prostate cancer is the second most common reason for cancer death in men. No imaging methods currently exist which are specific for detecting, imaging, and treating extracapsular or metastatic prostate cancer. The goal of this research was to develop novel nanoparticles that would specifically target human prostate cancer cells and simultaneously deliver a chemotherapeutic agent and superior magnetic resonance imaging (MRI) contrast agent to the prostate cancer cells for both therapy and MRI detection. This dissertation describes the synthesis and comprehensive characterization of superparamagnetic iron-platinum nanoparticles (SIPPs) and their subsequent encapsulation with the drug Paclitaxel, using …
Ethanol Exposure Impairs Glutamatergic Synaptic Transmission And Plasticity In The Ca1 Hippocampal Region During The Third Trimester-Equivalent Of Human Pregnancy: Implications For Fetal Alcohol Spectrum Disorder, Michael P. Puglia
Biomedical Sciences ETDs
Fetal alcohol spectrum disorder results from developmental exposure to ethanol. Although many organ systems are targeted by this teratogen, the central nervous system is exquisitely sensitive. Children with this disease often present with behavioral disorders as well as impairments in learning and memory. Ethanol exposure affects developmental processes throughout pregnancy; however, the third trimester-equivalent has demonstrated heightened sensitivity. Although the mechanism of action(s) of ethanol remains unknown, studies suggest that impairments in glutamatergic signaling and synaptic plasticity during the third trimester-equivalent period of development lead to alterations in synaptic formation and refinement. However, little is known about the developmental effects …
Florentine Palaces, Costly Signaling, And Lineage Survival, Michael K. Church
Florentine Palaces, Costly Signaling, And Lineage Survival, Michael K. Church
Anthropology ETDs
My dissertation evaluated whether the palaces built in Florence, Italy during the Renaissance are a form of costly signaling. Costly signaling theory was developed to explain why organisms have attributes and behaviors that appear to defy basic Darwinian logic by having costs that are not offset by obvious benefits. The theory proposes that such attributes and behaviors persist because they are reliable signals of information about the signalers. Signal audiences use the information content of signals to rank signalers and to modify their interactions with signalers in ways that benefit signalers. These interactions can involve mate choice, predation avoidance, status …
Assessment Of Field Effect In The Cancerous Prostate, Christina M. Haaland
Assessment Of Field Effect In The Cancerous Prostate, Christina M. Haaland
Biomedical Sciences ETDs
Prostate cancer is the second leading cause of cancer death in men. Prostate Specific Antigen (PSA) is the current indicator of prostate health, and needle core biopsy of the prostate is the standard of cancer diagnosis. However, PSA is not a specific indicator of cancer, and biopsy may miss actual tumor cells, leading to both false positive and false negative results, respectively. Therefore, better indicators of prostate cancer need to be identified. Field effect is the term used to describe the existence of genetically altered, although histologically normal, cells that surround an area of frank cancer. Better understanding and characterization …
Mechanisms Of Hydrogen Sulfide Induced Vasodilation, Olan Jackson-Weaver
Mechanisms Of Hydrogen Sulfide Induced Vasodilation, Olan Jackson-Weaver
Biomedical Sciences ETDs
Myogenic tone is an important regulator of blood flow and may contribute to peripheral vascular resistance and blood pressure. Myogenic tone is a luminal pressure-induced constriction of the vasculature that is mediated by a vascular smooth muscle cell (VSMC) plasma membrane potential (Em) depolarization and Ca2+ influx. Ca2+ sparks, which are ryanodine receptor (RyR) mediated Ca2+ release events, oppose myogenic tone by activating large-conductance Ca2+-activated K+ channels (BKCa) to hyperpolarize VSMC Em. The gaseous signaling molecules (gasotransmitters) NO and CO activate Ca2+ sparks to cause vasodilation. H2S, a third gasotransmitter produced by cystationine γ-lyase (CSE) in the vasculature, activates several …
Antibody-Mediated Protection Against Pulmonary Infection With Virulent Type A Francisella Tularensis, Gopi Mara-Koosham
Antibody-Mediated Protection Against Pulmonary Infection With Virulent Type A Francisella Tularensis, Gopi Mara-Koosham
Biomedical Sciences ETDs
Respiratory infections with the virulent type A strains of Francisella tularensis (Ft) cause pneumonic tularemia, an illness which results in high case fatalities in the absence of timely antibiotic treatment. Although immunization is an effective countermeasure, vaccines against pulmonary tularemia are currently unavailable. A better understanding of protective immune components is therefore needed to develop licensable vaccines against pulmonary tularemia. While the indispensability of cell-mediated immunity in protection against this gram-negative intracellular bacterium is well-documented, the protective role of antibodies (Abs) is unclear. Hence we examined the role of humoral immunity by developing a passive immunization model of respiratory tularemia …
Characterization Of G Protein-Coupled Estrogen Receptor (Gper) In Breast Epithelial Proliferation And Morphogenesis, Allison Layne Scaling
Characterization Of G Protein-Coupled Estrogen Receptor (Gper) In Breast Epithelial Proliferation And Morphogenesis, Allison Layne Scaling
Biomedical Sciences ETDs
Estrogen (17β-estradiol, E2) plays an important role in regulating an array of functions in both male and female reproductive physiology. In the mammary gland, E2-induced proliferation, ductal outgrowth and subsequent branching morphogenesis is required for proper development of the breast. In males, E2 is required for proper testicular development, spermatogenesis, and sperm maturation in the epididymis, but can also negatively regulate these functions with inappropriate exposure. The effects of E2 in these organs have long been attributed to classical estrogen receptors (ERα and ERβ), due to the observed effects in ER-/- mice; however, GPER is abundantly expressed in male and …