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Electrochemical Oxidation Of Antibiotic, Antihistamine, Analgesic And Cns Stimulant Pharmaceuticals, Md Mosaddek Hossen

Chemical and Biological Engineering ETDs

Electrochemical oxidation is a common method for the degradation of chemicals by applying potential at a definite value. In this research, ‘cyclic voltammetry’ experiments were conducted to find out the oxidation potential for 8 different pharmaceuticals. Mainly, 3 different pH solutions (pH 6.0, 7.5, 9.0) and 9 different concentrations (1, 2, 5, 10, 20, 50, 100, 200, 500 µM) were studied for each of the pharmaceuticals in this experiments. Acetaminophen, Ibuprofen, Naproxen Sodium, Caffeine showed oxidation peak at 0.34-0.79V, 1.37- 1.39V, 0.94-1.01V, 1.44-1.55V respectively at different pH and concentrations. Antibiotic and antihistamine pharmaceuticals i.e. Erythromycin Hydrate, Triclosan, Sulfanilamide, Diphenhydramine Hydrochloride …

Belén’S Plaza Vieja And Colonial Church Site: Memory, Continuity And Recovery, Samuel E. Sisneros

University Libraries & Learning Sciences Faculty and Staff Publications

This is my capstone project for completion of a Post MA certificate in Historic Preservation and Regionalism. I received the degree in Spring, 2019. The project involves recovering the legacy of a historic colonial church site in Belén, New Mexico. The work involves the descendant community’s sense of place and the continuity of memory and sacredness of Belen’s first church and original plaza.

Compliant Culture Platforms With Independently Tunable Stiffness And Electrical/Optical Functionality, Nadeem Abdul

Electrical and Computer Engineering ETDs

Interfacing biological cells and solid-state devices is crucial in many applications, ranging from well-established fields, such as electrophisiology, to the newly developed areas of optogenetics and mechanobiology. Most biological cells are anchored to substrates with elastic modulus, E, in the range of ~1 to 100 kPa, the moduli of brain-tissue and osteoid, respectively. On the other hand, bulk semiconductor substrates have ~6 orders of magnitude higher elastic modulus. This large elastic mismatch between devices and cells natural microenvironments is an issue for bio-devices integration, as cells are highly sensitive to mechanical cues. Specifically, cells exert traction forces on their surroundings …

Memory Effects In Brownian Motion, Random Walks Under Confining Potentials, And Relaxation Of Quantum Systems, Matthew Chase

Physics & Astronomy ETDs

This dissertation is a report on a number of distinct topics in the field of non-equilibrium statistical mechanics including the evolution of classical as well as quantum systems.

The evolution of an object that is described by the Ornstein-Uhlenbeck process generalized through a time-nonlocal attraction is considered. The time-nonlocality is taken to be represented in the Langevin description through the presence of memory. Analysis of the Langevin equation is performed for algebraic and delay-type memories. An equivalent \emph{bona-fide} Fokker-Planck equation is constructed.

A random walker subjected to a non-standard confining potential, taken to be a piece-wise linear function, is analyzed. …

Otras Perspectivas (Other Perspectives), Volume 18, Issue 01, December 2016, Occupational Therapy Graduate Program

OTras Perspectivas: UNM Occupational Therapy Program Newsletter

Acknowledging that the success of the Occupational Therapy Program hinges on the mutual investment of community and friends beyond the local community, the UNM Occupational Therapy Program faculty and staff have initiated this newsletter. The goal is to provide an additional forum for communication, and provide updates about the program's development, faculty, students, alumni, and friends.

Zacatecas Authorities Reject Protected-Area Designation In Mining Region, Carlos Navarro

SourceMex

No abstract provided.

Report For Nmdgf Permit: 3094, 2016, Wally Murphy

Natural Heritage New Mexico Documents

Document from New Mexico Department of Game & Fish Scientific permit.

Development Of Metal Matrix Composite Gridlines For Space Photovoltaics, Omar K. Abudayyeh

Chemical and Biological Engineering ETDs

Space vehicles today are primarily powered by multi-junction photovoltaic cells due to their high efficiency and high radiation hardness in the space environment. While multi-junction solar cells provide high efficiency, microcracks develop in the crystalline semiconductor due to a variety of reasons, including: growth defects, film stress due to lattice constant mismatch, and external mechanical stresses introduced during shipping, installation, and operation. These microcracks have the tendency to propagate through the different layers of the semiconductor reaching the metal gridlines of the cell, resulting in electrically isolated areas from the busbar region, ultimately lowering the power output of the cell …

An Exploration Of Style Transfer Using Deep Neural Networks, Cameron Y. Smith

Computer Science ETDs

Convolutional Neural Networks and Graphics Processing Units have been at the core of a paradigm shift in computer vision research that some researchers have called `'the algorithmic perception revolution." This thesis presents the implementation and analysis of several techniques for performing artistic style transfer using a Convolutional Neural Network architecture trained for large-scale image recognition tasks. We present an implementation of an existing algorithm for artistic style transfer in images and video. The neural algorithm separates and recombines the style and content of arbitrary images. Additionally, we present an extension of the algorithm to perform weighted artistic style transfer.

Learning And Memory Abnormalities In Mice Deficient In The Rna-Binding Protein Ksrp, Sarah L. Olguin

Biomedical Sciences ETDs

Post-transcriptional regulation plays a critical role in the function and development of the nervous system; especially in the control of specific subsets of mRNAs localized to dendrites and axons. One such regulatory mechanism is the stabilization or disruption of mRNA through association of RNA binding proteins (RBPs) such as the KH-type splicing regulatory protein (KSRP). We have previously shown that loss of KSRP results in dysregulation of GAP-43 and increased growth of hippocampal neurons in vitro. Therefore, KSRP-/- and KSRP+/- animals were subjected to a battery of behavioral tests including Novel Object Recognition and Trace Fear Conditioning to assess hippocampal …

Shifts In The Relative Importance Of Competition And Mutualism For Communities And Ecosystems, Lukas Patrick Bell-Dereske

Biology ETDs

Plant species interact with at least one, likely many, microbial mutualist throughout their life cycles. These microbial mutualists can have strong effects on plant communities and ecosystem processes. Fungal endophytes within the genus Epichloë associate with ~20%–30% of grass species and have been shown to have strong effects on plant communities. Here I described the effect of Epichloë amarillans associated with the dominant grass species, Ammophila breviligulata, on nutrient cycling, below-ground microbial community, and compare the strength of its effects on plant communities to plant-plant competition.

In chapters one and two, I examine the effects of Epichloë on litter …

The Molecular Systematics And Phylogeography Of The Widespread North American Meadow Vole (Microtus Pennsylvanicus), Donavan J. Jackson

Biology ETDs

The climatic and environmental fluctuations of the Quaternary played an integral role in geographic distribution and genetic structure within many organisms today. Understanding how these historical biogeographic events may have partitioned genetic variation throughout the landscape is critical to forecasting the implications of modern climate change and how animals will respond to projected climate shifts. Through geographic and taxonomically comprehensive sampling, we used multi-locus and species delimitation analyses along with niche modeling methods to investigate the evolutionary and biogeographic history of the meadow vole, Microtus pennsylvanicus. The findings of this study highlight the vulnerability and importance that special consideration …

Plant-Biocrust Interactions Mediated By The Fungal Loop, Eva Dettweiler-Robinson

Biology ETDs

Plant-microbial interactions influence biogeochemical cycles. Plants and biological soil crusts are primary producers in drylands. Biocrusts include cyanobacteria, lichens, mosses, algae, fungi, bacteria, and archaea on the soil surface, some of which fix atmospheric nitrogen. I investigated controls on biocrust carbon fluxes and their contribution to ecosystem fluxes, the incorporation of plant-derived carbon into biocrusts, and the role of soil fungi in promoting performance of plants and biocrusts. Biocrusts responded to temperature and moisture differently by biome. Biocrusts in grasslands/shrublands contributed >25% of total summertime ecosystem respiration, but biocrusts in savannas/woodlands contributed < 1%. Biocrusts contributed < 2% to GPP in any biome. To augment their native photosynthesis, biocrusts may include 16% plant-derived carbon. Fungal connections improved plant and biocrust performance and reduced differences in the CN ratio between organisms compared to when connections were impeded. Investigation of interactions among biocrusts, plants, and fungi has improved understanding of resource cycling in drylands.

Searching Neuroimaging Biomarkers In Mental Disorders With Graph And Multimodal Fusion Analysis Of Functional Connectivity, Hao He

Electrical and Computer Engineering ETDs

Mental disorders such as schizophrenia (SZ), bipolar (BD), and major depression disorders (MDD) can cause severe symptoms and life disruption. They share some symptoms, which can pose a major clinical challenge to their differentiation. Objective biomarkers based on neuroimaging may help to improve diagnostic accuracy and facilitate optimal treatment for patients. Over the last decades, non-invasive in-vivo neuroimaging techniques such as magnetic resonance imaging (MRI) have been increasingly applied to measure structure and function in human brains. With functional MRI (fMRI) or structural MRI (sMRI), studies have identified neurophysiological deficits in patients’ brain from different perspective. Functional connectivity (FC) analysis …

Approaches For Capturing Time-Varying Functional Network Connectivity With Application To Normative Development And Mental Illness, Barnaly Rashid

Electrical and Computer Engineering ETDs

Since the beginning of medical science, the human brain has remained an unsolved puzzle; an illusive organ that controls everything- from breathing to heartbeats, from emotion to anger, and more. With the power of advanced neuroimaging techniques, scientists have now started to solve this nearly impossible puzzle, piece by piece. Over the past decade, various in vivo techniques, including functional magnetic resonance imaging (fMRI), have been increasingly used to understand brain functions. fMRI is extensively being used to facilitate the identification of various neuropsychological disorders such as schizophrenia (SZ), bipolar disorder (BP) and autism spectrum disorder (ASD). These disorders are …

Network Inference Driven Drug Discovery, Gergely Zahoránszky-Kőhalmi, Tudor I. Oprea, Cristian G. Bologa, Subramani Mani, Oleg Ursu

Biomedical Sciences ETDs

The application of rational drug design principles in the era of network-pharmacology requires the investigation of drug-target and target-target interactions in order to design new drugs. The presented research was aimed at developing novel computational methods that enable the efficient analysis of complex biomedical data and to promote the hypothesis generation in the context of translational research. The three chapters of the Dissertation relate to various segments of drug discovery and development process.

The first chapter introduces the integrated predictive drug discovery platform „SmartGraph”. The novel collaborative-filtering based algorithm „Target Based Recommender (TBR)” was developed in the framework of this …

Development Of In Vivo Systems For Detecting And Studying Ribosome Inhibition By Small Molecules, Shijie Huang

Chemistry and Chemical Biology ETDs

The ribosome is the quintessential antibacterial drug target, with many structurally and mechanistically distinct classes of antibacterial agents acting by inhibiting ribosome function. Detecting and quantifying ribosome inhibition by small molecules and investigating their binding modes and mechanisms of action are critical to antibacterial drug discovery and development efforts. To develop a ribosome inhibition assay that is operationally simple, yet provides direct information on the drug target and the mechanism of action, we have developed engineered E. coli strains harboring an orthogonal ribosome controlled green fluorescent protein reporter that produce fluorescent signal when the O-ribosome is inhibited. As a proof …

Trans/Formations: A Photovoice Assessment Of Transgender People’S Wellness, E. Ricky Hill

Communication ETDs

The purpose of this study is to identify and understand ways transgender and gender non-conforming people living in Albuquerque, New Mexico are communicating about and understanding their health and wellness needs and the health and wellness needs of their community. Partnering with the Transgender Resource Center of New Mexico, I used a community-based participatory approach to work on a Photovoice project that identified health and wellness related needs as defined by the community. Emergent themes identified by the participants highlighted various challenges and strengths to health and wellness for transgender and gender non-conforming people. I identify five core cultural premises …

Development And Application Of An Expanded Streptomyces Genetic Code, Jingxuan He

Chemistry and Chemical Biology ETDs

Actinobacteria, especially those of genus Streptomyces, are a prominent source of bioactive natural products. The ability to site-specifically incorporate unnatural amino acids (UAAs) into natural product biosynthetic enzymes and ribosomally derived peptides in these organisms would constitute a valuable tool for drug discovery and development. The work described in this dissertation focuses on development and application of an expanded Streptomyces genetic code, including development of UAA incorporation systems based on amber suppression and sense codon reassignment, structural diversification of the model thiopeptide natural product thiostrepton using UAAs, and mapping protein-protein interactions in type II polyketide biosynthetic enzymes using photocrosslinking …

Theory And Practice Of Computing With Excitable Dynamics, Alireza Goudarzi

Computer Science ETDs

Reservoir computing (RC) is a promising paradigm for time series processing. In this paradigm, the desired output is computed by combining measurements of an excitable system that responds to time-dependent exogenous stimuli. The excitable system is called a reservoir and measurements of its state are combined using a readout layer to produce a target output. The power of RC is attributed to an emergent short-term memory in dynamical systems and has been analyzed mathematically for both linear and nonlinear dynamical systems. The theory of RC treats only the macroscopic properties of the reservoir, without reference to the underlying medium it …

Engineering Small Molecule Based Dimerization To Induce Translation And Provide Optogenetic Control, Catherine Wright

Chemistry and Chemical Biology ETDs

We wanted to develop a system that combines the spatial control of photoactivation and control of translation to build a tool to spatially control translation in neurons. This kind of tool could be used to investigate the role of spatially controlled translation of any protein in neural behavior. In this way the development and growth of neural processes could be studied to elucidate the mechanisms for spatially sensitive events such as pathfinding, repair, or long-term potentiation.

Chemically induced dimerization was used to install a switch into the activation of translation for specific genes. An abscisic acid (ABA) dependent dimerization of …

Montane Valley Grassland Plant Communities Are Highly Resistant To Wildfire, Martina M. Suazo

Biology ETDs

Understanding the ecological role of fire in fire-adapted plant communities is of great importance for restoration and preservation; however, limited research has been conducted on the response of upper elevation, C₃ grassland plant communities to wildfire. This study investigates the effects of the Las Conchas wildfire of 2011 on plant community structure and function in the montane valley grasslands of the Valles Caldera National Preserve, Jemez Mountains, New Mexico, USA. Long term monitoring of nine burned and seven unburned grassland sites was used to measure vegetation composition and dynamics both spatially and temporally relative to fire. Results show that …

Towards Deeper Understanding In Neuroimaging, Rex Devon Hjelm

Computer Science ETDs

Neuroimaging is a growing domain of research, with advances in machine learning having tremendous potential to expand understanding in neuroscience and improve public health. Deep neural networks have recently and rapidly achieved historic success in numerous domains, and as a consequence have completely redefined the landscape of automated learners, giving promise of significant advances in numerous domains of research. Despite recent advances and advantages over traditional machine learning methods, deep neural networks have yet to have permeated significantly into neuroscience studies, particularly as a tool for discovery. This dissertation presents well-established and novel tools for unsupervised learning which aid in …

Electrochemical Fabrication Of Energetic Thin Films, Jonathan J. Coleman

Chemical and Biological Engineering ETDs

Current thermal battery heat sources suffer from slow reaction propagation rates and require extreme care when handling to protect from inadvertent ignition sources. Nanostructured intermetallic heat sources are strong candidates for improved heat sources as they have high enthalpy of reaction, are highly conductive before and after firing and are completely gasless reactions. Current fabrication methods of these heat sources rely on a PVD multistep layering process that is time and capital intensive, and cost prohibiting to their use. The composition and nanostructuring these films require can be provided with electrochemical codeposition, where the two components (aluminum and nickel) are …

November 11, 2016 Finance & Facilities (F&F) Committee Meeting, Evp For Administration

Finance and Facilities Committee

Documents related to the November 11, 2016 Board of Regents' Finance and Facilities Committee Meeting. (Agenda, Minutes, eBook, Notice)

How Do Faculty At The University Of New Mexico Use Humor In Online Teaching, John T. Granato

Organization, Information and Learning Sciences ETDs

Humor is a ubiquitous experience that facilitates learning, social coordination and wellbeing. This study examined how the faculty at the University of New Mexico used humor in its online courses. The process involved faculty interviews, a focus group of instructional online designers, questionnaires and documentation to collect data, and then used thematic analysis and code development to arrive at its findings. The study found that the humor pedagogy at the University of New Mexico has fallen into disuse for online courses because of (1) a hesitation (fear) to use humor, (2) fear of what students would think, and (3), hesitation …

Groundwater Restoration Following In-Situ Leach Mining Of Uranium, Omar A. Ruiz Lopez

Civil Engineering ETDs

From 1950 to the early 1980’s New Mexico played an important role in the production of uranium (U) for the nuclear power industry and the nation’s weapon programs. Though the U mining and milling industry in New Mexico is inactive at present, increased interest in nuclear energy as a CO₂ free power source has led to proposals for renewed development of U resources. In particular, U mining projects have been proposed using both underground mining and in situ leach (ISL) mining. When feasible, ISL mining minimizes waste by eliminating; mine waste, mine dewatering, radiation exposure and the recovered U …

Sex Ed To Go- An Analysis Of Comprehensive Sexual Education Mobile Phone Applications, Kerstin M. Kalke

Communication ETDs

The United States has one of the highest teen pregnancy rates among developed countries and the numbers of STIs have increased during the last few years. Mobile phone applications constitute a promising platform to disseminate sexual health information and to reduce adverse health outcomes, particularly among teens. In order to be effective, apps have to follow a comprehensive approach to sexuality education, include concepts of behavior change theories, and adhere to health literacy principles.

This study used a mixed-methods approach consisting of a quantitative content analysis and qualitative thematic analysis to assess the quality of sexual education apps available to …

Dielectric Characterization Of Mylar And The Effects Of Doping Processes, Cami B. Belcher

Chemical and Biological Engineering ETDs

Mylar® polymer is a bi-axially oriented polyethylene terephthalate (PET) polymer film used widely as a dielectric, specifically in capacitors. The dielectric characteristics of Mylar have been well studied and documented over the years; however, many of the mechanisms responsible for dielectric breakdown and failure are not understood for modified versions of the material. Previous studies on Mylar confirm that factors such as temperature, humidity, and voltage ramp rates can also have a significant effect on the dielectric properties and measurement of the dielectric properties. This study seeks to determine how dielectric properties, including permittivity, dielectric loss, and breakdown strength, are …

Influence Of Anterior Thalamic Inactivation On The Retrieval Of Spatial Reference Memory And Working Memory In The Radial Arm Maze, Ryan E. Harvey

Psychology ETDs

Previous studies have shown that the anterior thalamic nuclei (ATN) contain a large population of head direction cells, which fire as a function of an animal’s directional orientation in an environment, thereby providing a compass-like representation guiding navigation. Recent work has suggested that directional orientation information stemming from the ATN is critical for the generation of hippocampal and parahippocampal spatial representations, and may contribute to the establishment of unique spatial representations in radially oriented tasks such as the radial arm maze. While studies have confirmed that ATN lesions impair the acquisition of new spatial information in variants of the radial …