Digital Commons Network^™

From Olfaction To Immunity: Characterization Of Nasal Immunity In Bony Fish, Ali Sepahi

Biology ETDs

The olfactory system is a common route pathogen entry in vertebrates. As a consequence, the nasopharynx-associated lymphoid tissue (NALT) needs to rapidly clear infections without compromising the sense of olfaction. NALT is present in teleost fish but its cellular and molecular mechanisms of action have not been investigated to this date. This dissertation focuses on three aims: 1. investigating the role of CCL19-like as a primordial chemokine in vertebrate nasal immunity, 2. determining the presence of tissue microenvironments within the olfactory organ (OO) of rainbow trout, and 3. understanding the immune contributions of olfactory sensory neurons (OSNs) in teleosts against …

Sunshine ‘89, David O'Connor

English Language and Literature ETDs

Sunshine ’89 is a coming-of-age-novel, set in Canada in 1989, this creative work explores the travel of a young adoptee from a remote outpost to the bourgeois center of the country in order to pursue a life in the theatre. What ensues is a mentor-apprentice story exploring art, race, sexuality, performance, aging, dementia, alcoholism, politics, Canada, and other theme. Above all, a page- turner and picaresque romp meant to entertain and challenge.

Investigations On The Role Of The Immune System In Mammary Development And Maternal Immunity In The Marsupial, Monodelphis Domestica, Bethaney D. Fehrenkamp

Biology ETDs

All newborn mammals are highly dependent upon milk for nourishment and immune protection. This is especially true for marsupials, a lineage of mammals with a short gestation, limited placental development, and an increased reliance on an extended lactation period. Most newborn marsupials do not receive passive maternal immunity in utero and therefore are entirely dependent upon factors within the milk for immune protection until capable of mounting their own response. In this project we seek to characterize the complex lactation program utilized by marsupials, and seek greater understanding of the maternal role in the establishment of the developing immune system …

Genomic Signatures Of Adaptive Evolution, Jessica A. Weber

Biology ETDs

Comparative genomics has revolutionized virtually all fields of biology including the study of evolution. In this dissertation, I used next-generation sequencing to explore the evolutionary histories and adaptive evolution of a diverse set of taxa. Comparisons ranged across time scales, from population-level genetic diversity studies to questions spanning the deepest branches of the metazoan lineage. Whole genome sequencing of 50 unrelated Korean individuals revealed that Koreans have a distinct genetic history from the Chinese and Japanese populations. Our Korean-specific variome database was used to identify novel disease-causing variants in the Korean population, highlighting the value of high-quality ethnic variation databases …

Developing More Specific Mirna Biogenesis Inhibitors To Get Effective Regulation Of Mirnas, Umesh Bhattarai

Chemistry and Chemical Biology ETDs

MicroRNAs (miRNAs) are short (~ 22 nucleotides long) noncoding RNAs that regulate gene expression post-transcriptionally. They control the expression of various genes that are crucial for cellular function, development and human diseases. Tools to regulate the level and function of miRNAs facilitate the studies of their functions and have therapeutic applications. In my thesis, I developed a newly customizable miRNA biogenesis inhibitor to regulate miRNAs.

Antisense oligonucleotides (ASOs) have been used to regulate miRNA through controlling their production or function. Although commonly used due to the fact that they are easy to design, several limitations exist for ASOs including serious …

Revealing Silences: The Representation Of Black Identities In Hispanic Afro-Caribbean Autobiographical And Biographical Writing, Bryn Campbell

Spanish and Portuguese ETDs

This project explores how the historical contexts of the Hispanic Caribbean, including the regions of the Circum-Caribbean and the Caribbean Diasporas in the United States, have sustained dominant racial and nationalist ideologies that continue to silence or negate the identity of Afro-Caribbean subjects in national letters. My research focuses on the autobiographical and biographical writing of four Hispanic Afro-Caribbean men: Autobiografía de un esclavo (1840) by Juan Francisco Manzano¾originally published and translated to English in 1840 by Richard R. Madden¾ Klabel (2002) by Víctor Virgilio López García, Down These Mean Streets (1967) by Piri Thomas, and Las criadas de la …

Autophagy Is Stimulated By Acute High Intensity Interval Exercise In Human Skeletal Muscle And Electrical Pulse Stimulation In C2c12 Myotubes In Vitro, Kurt A. Escobar

Health, Exercise, and Sports Sciences ETDs

Purpose: 1) To compare the effects of an acute bout of HIIT exercise (treadmill running) on autophagy to MICT exercise in human skeletal muscle 3 hours post exercise, and 2) to test an in vitro model of muscle contraction-induced autophagy using electrical pulse stimulation in C2C12 myotubes. Methods: Study 1: Ten recreationally active males and females completed a bout of high intensity interval training (HIIT) exercise and moderate intensity continuous exercise (MICT) exercise in a fasted state. Muscle biopsies from the vastus lateralis were taken pre and 3 hours post-exercise. Muscle tissue was analyzed for protein expression of markers of …

Conceptual Structures Of Vietnamese Emotions, Hien T. Tran

Linguistics ETDs

ABSTRACT

This dissertation presents a comparative study of the metaphoric and metonymic systems underlying the conceptualizations of two emotions, anger and sadness, in Vietnamese, American English, and Chinese. The analytic and theoretical approach is based on previous studies by Lakoff and Kövecses (1987), Kövecses (1988), Barcelona (1986), King (1989) and Yu (1995). The research presented here on emotion concepts reveals cultural variation and potential universals in the conceptualization of emotions. These results support the “Cultural Embodied Prototype” view proposed by Kövecses (2004:14) which proposes that conceptualizations of human emotions is motivated by both physiological embodied experiences (physiological embodiment) and the …

Neurobehavioral Signatures In Children-Victim Of Bullying, Isabel Solis

Psychology ETDs

Experiencing bullying victimization can lead to detrimental damage to a child’s life potential, reduced long-term contributions to society, and in severe cases, to suicide or desperate acts of defensive aggression, such as school shootings. The current study aimed to examine risk factors that may increase the vulnerability of a child to become a target of bullying victimization and the related consequences of victimization, using rigorous neuropsychological and EEG measures. The end-goal is to translate these findings into a program of preventive intervention increasing the child’s resilience and improving social culture among youth in the academic environment. We propose a two-component …

Niemann-Pick C1, Its Connection To Obesity, And Its Impact On Human Evolution, Joseph Joshua Castillo

Biomedical Sciences ETDs

Niemann-Pick type-C disease is a rare autosomal recessive neurodegenerative disease that classically presents in the first decade, leading to ataxia, vertical-gaze palsy, loss of communication skills, epileptic seizures, and eventually death. The stark reality about NPC disease underlines the important role the NPC1 protein plays in whole-body lipid homeostasis. It is no surprise, then, that the NPC1 gene has been associated with other diseases as well, such as obesity, diabetes, and Ebola virus infection. In this manuscript, a connection will be made that intertwines genetics, biochemical and molecular mechanisms, physiology, and evolutionary pressures, and will explain how a gene, discovered …

Metal Reactivity In Laboratory Burned Wood From A Watershed Affected By Wildfires, Asifur Rahman

Civil Engineering ETDs

Massive amounts of wood ash are deposited into nearby streams as a result of runoff from storm events after increasing frequency of wildfire events that negatively affect water quality. Ash and debris from burned vegetation can alter the pH, turbidity and dissolved oxygen (DO) in water and can release heavy metals, organic matter, and nutrients. We investigated interfacial processes affecting metal mobility in wood ash burned under laboratory-controlled conditions using aqueous chemistry, microscopy and spectroscopy analyses. Wood was collected from the Valles Caldera National Preserve in New Mexico which has experienced two wildfires since 2011 that have caused devastating effects. …

Data-Driven Uncertainty Quantification Interpretation With High Density Regions, Matthew Gregor Peterson

Computer Science ETDs

In a time when data is being constantly generated by phones, vehicles, sensor net- works, social media, etc. detecting anomalies with in the data can be very crucial. In cases where we know little prior knowledge about the data, it becomes difficult to extract uncertainty about our results. In this thesis, we will propose a framework in which we can extract uncertainty distributions from data-driven modeling prob- lems. We will show some concrete examples of how to apply framework and provide some insight into what the uncertainty distributions are telling us using High Density Regions (HDRs).

Analyzing The Medical Definition Of Death In Criminal Homicide Prosecution, Mariah Wood

Nursing ETDs

I investigated the use of the medical definition of human death in the criminal justice system and the impact of this definition on the prosecution of criminal homicide. The units of design for this research were two violent crimes cases investigated by the Homicide Unit of the Albuquerque Police Department. Data was collected from officer interviews, case files, Office of the Medical Investigator reports, media and social media.

I identified the themes of pursuit of justice, frustration, and family from the collected data. Key findings include that the medical definition of human death causes confusion and delay in the criminal …

Effect Of Undergraduate Research Programs On Retention Of Hispanic Students, Kiyoko N. Simmons

Organization, Information and Learning Sciences ETDs

The Hispanic population in the United States has been increasing, which is affecting the number of Hispanic student population in the higher education. In spite of the rapid increase of Hispanic student population, little empirical research has been conducted on the Hispanic student’s college success. This study investigated the effect of participating in holistic undergraduate research programs on retention outcome of Hispanic students at The University of New Mexico. UNM is a public Hispanic-Serving Institution where 47.3 percent of undergraduate students are Hispanic in 2016.

The Vincent Tinto’s theory of student departure and the five critical factors of retention developed …

Soil Properties Explain Changes In Soil Microbial Enzyme Activity With Depth In A Piñon-Juniper Woodland, Amanda B. Sacks

Biology ETDs

Semi-arid ecosystems play a major role in the global carbon cycle. These ecosystems, including piñon-juniper (PJ) woodlands, are experiencing extreme drought. As such, it is vital to characterize both above and below-ground processes in these systems in order to understand their vulnerability to future drought and other changes in climate.

Soils microbial communities play a critical role in nutrient cycles, as well as carbon storage, within PJ woodlands. More specifically, microbes aid the decomposition and mineralization of key nutrients, including carbon, nitrogen and phosphorus, through the use of extracellular enzymes. Measuring microbial enzyme activity, therefore, can provide insight into how …

Religiosity/Spirituality And Cancer Risk Assessment For Hereditary Breast And Ovarian Cancer: Latina And Non-Latina Women In New Mexico, Belinda Vicuna Tellez

Psychology ETDs

Introduction: Although cancer risk assessment for high-risk individuals and families can offer life-saving information and options for cancer risk management, Latinas have historically underutilized cancer prevention services. Much needed is a better understanding of what encourages and discourages engagement in cancer risk assessment services among Latino populations. Religiosity/spirituality is potentially relevant to such engagement given religion has often been a central coping resource for Latina cancer survivors.

Aim: This study explored the potential impact of religiosity/spirituality and psychological processes on how Latinas and non-Latinas approach decisions regarding preventative health behaviors.

Methods: As a small subset of a larger research project, …

Laterality In The Power Five And Group Of Five Conferences In Women's College Softball, Jon C. Nachtigal

Health, Exercise, and Sports Sciences ETDs

Females in sport are under-represented in data and analysis when compared to their male counterparts. This disparity also applies to women’s softball in comparison to men’s baseball. To help fill this gap, this study evaluated the extent and impact of laterality in women’s college softball’s Power Five and Group of Five conferences from 2015-2017.

This study focused on the extent of a left-sided lateral preference in women’s college softball, possible interactions between throwing hand and batting preference, to what extent the platoon effect exists in the sport, and the extent of positional bias in the sport. As one of the …

A Multi-Level Study Of Clearance: The Role Of Gender, Jenna Dole

Sociology ETDs

Objective. To examine the role that gender plays in the clearance of a reported criminal incident, and whether it varies across places. Methods. Using multi-level logistic regressions, data from the 2014 National Incident-Based Reporting System (NIBRS), 2010 Census data, 2013 Law Enforcement Management Statistics, and the 2010 Municipal Yearbook are used to examine the effects of a victim’s sex on crime clearance. Results. Women are initially advantaged in clearance before controlling for any evidentiary factors. However, most of the relationship is explained away when controlling for the relationship between the victim and the offender. Women are more likely to be …

Bioengineering Of An In Vitro Microphysiological Human Alveolar Model, Ayesha Arefin

Nanoscience and Microsystems ETDs

Drugs tested on animal models do not always produce the same results in humans; a reliable in vitro lung model can bridge the divide between the two. Because the alveolus is a target for several drugs, an alveolar model can be a platform for both designing drugs and studying lung diseases. A model should allow for gas exchange, growth of primary alveolar epithelial cells, extracellular matrix production, and have similar mechanical properties to alveoli, creating an environment conducive to normal metabolic activity and cellular responses. Existing artificial alveolar models that use polymeric membranes to sustain lung cells are limited by …

American Indian Student Motivation At A Tribal College, Rebecca L. Izzo

Individual, Family, and Community Education ETDs

The purpose of this study was to explore relationships between motivational characteristics of American Indian college students attending a tribal college. The Inventory of School Motivation (ISM) was utilized to identify motivational constructs. The literature in general continues to portray American Indian students as the lowest academically achieving subgroup as well as having a lack of persistence and high dropout rate in higher education. This study identified areas that support motivation to attend college, which then can be shared with the tribal college to develop programs and innovations to recruit and sustain American Indian students in education, as well as …

Synchronization In An Externally Driven Mechanical Oscillators Experiment, Sumit Chhabria

Electrical and Computer Engineering ETDs

Our experimental system studies the effects of externally controlled oscillation on directly and indirectly driven system of metronomes. This is analogous to many practical systems such as pacemaker effect on heart cells, the external light effect on the suprachiasmatic nucleus in the brain. Here the pacemaker can be compared to an external driving force to the system where the heart cells are our oscillating system. Also, in the suprachiasmatic nucleus cell system, the external input is external light which synchronizes the cell. We explore the synchronization of directly and indirectly driven metronomes due to externally provided forcing.

We designed an …

Psychological Factors And The Relation Between Neighborhood Conditions And Latino Health: A Mixed Methods Study, Patricia Rodriguez Espinosa

Psychology ETDs

Latinos, the largest racial/ethnic minority group in the US, face multiple health inequities including higher rates morbidity and mortality. Despite the importance of context and the wide range of stressors faced by this population, the majority of the literature on Latino and immigrant health concentrates on issues related to cultural adaptation processes. Using a socialdeterminants of health framework, the present convergent mixed methods study investigated the relation between neighborhood conditions and Latino health with a psychological lens. A total of 361 Latino residents of Bernalillo County, the largest county in Albuquerque, New Mexico, were recruited to complete a series of …

The Investigation Of Silica Removal In Reverse Osmosis Concentrate By Changing Design Parameters, John M. Stomp Iv

Civil Engineering ETDs

Silica at high concentrations can precipitate and polymerize, forming scales on heat exchangers, boilers and turbines in industrial equipment, and on the feed side of the semi-permeable membranes in Reverse Osmosis (RO). Silica scale can cause decreased efficiency, increased treatment costs and, in some cases, irreversible damage. The removal of silica scale is challenging because it requires the handling of dangerous and hazardous chemicals. Therefore, much research has gone into the removal of soluble silica. The purpose of this research was to compare the overall effectiveness of silica removal in RO concentrate water with freshly precipitated Mg(OH)₂ and Fe(OH) …

Regulating Mirna Biogenesis By Small Molecules, Hao Yan

Chemistry and Chemical Biology ETDs

MiRNAs are key cellular regulators and their dysregulation is associated with many human diseases. The development of miRNA inhibitors has significant implications for the therapy of diseases associated with aberrant miRNA expression. It also provides chemical tools for studying miRNA function. This dissertation focuses on the development of small-molecule based miRNA inhibitors targeting miRNA biogenesis.

The dissertation consists of four chapters. In Chapter 1, the biogenesis of miRNA was first introduced, followed by the explanation of miRNA function in health and disease. Then the approaches used for regulating miRNA were reviewed. Finally, the difficulties with miRNA regulation were summarized.

One …

Novel Compact Narrow-Linewidth Mid-Infrared Lasers For Sensing Applications, Behsan Behzadi

Optical Science and Engineering ETDs

The mid-infrared (2-14 μm) spectral region contains the strong absorption lines of many important molecular species, which make this region crucial for several well-know applications such as spectroscopy, chemical and biochemical sensing, security, and industrial monitoring. To fully exploit this region through absorption spectroscopic techniques, compact and low-cost narrow-linewidth (NLW) mid-infrared (MIR) laser sources are of primary importance.

This thesis is focused on three novel compact NLW MIR lasers: demonstration and characterization of a new glass-based spherical microlaser, investigation of the performance of a novel fiber laser, and the design of a monolithic laser on a silicon chip. Starting with …

Developing Droplet Based 3d Cell Culture Methods To Enable Investigations Of The Chemical Tumor Microenvironment, Jacqueline Alexandria De Lora

Biomedical Sciences ETDs

Adaptation of cancer cells to changes in the biochemical microenvironment in an expanding tumor mass is a crucial aspect of malignant progression, tumor metabolism, and drug efficacy. In vitro, it is challenging to mimic the evolution of biochemical gradients and the cellular heterogeneity that characterizes cancer tissues found in vivo. It is well accepted that more realistic and controllable in vitro 3D model systems are required to improve the overall cancer research paradigm and thus improve on the translation of results, but multidisciplinary approaches are needed for these advances. This work develops such approaches and demonstrates that new droplet-based cell-encapsulation …

Catalytic Functionalization Of Organoaluminum Reagents And Olefins By Cross-Coupling With Copper And Nickel, Bijay Shrestha

Chemistry and Chemical Biology ETDs

This thesis is divided into two parts. The first part focuses on the Cu-catalyzed cross-coupling of organoaluminum reagents with organohalides. One of the most powerful tools for the construction of C-C bonds is cross-coupling. But, this reaction is predominantly catalyzed by Pd, a rare and expensive transition metal, which inevitably makes the process unsustainable in the long-term. Furthermore, Pd-catalyzed cross-coupling also shows low tolerance for alkyl and heteroaryl substrates because of β-hydride elimination and catalyst deactivation, respectively. Although these issues remain largely solved by using sterically hindered and electron-rich ligands, however making these types of ligands is synthetically challenging and …

Mainland Southeast Asia In The Longue Durée: A Zooarchaeological Test Of The "Broad Spectrum Revolution" In Northern Thailand, Cyler Norman Conrad

Anthropology ETDs

In northern Thailand, previous zooarchaeological research suggests that hunter-gatherers consumed a broad diversity of animal resources during the Pleistocene-Holocene transition and afterwards (Gorman 1971a). This is a pattern characteristic of Kent Flannery’s (1969) “broad spectrum revolution” hypothesis. Based primarily on presence and absence evidence, faunal assemblages in northern Thailand typically include species of mammals, reptiles, birds, fish and shellfish, suggesting that prehistoric foragers consumed a wide range of taxa within this mainland Southeast Asian tropical environment. Although zooarchaeological analyses commonly identify this pattern within prehistoric cave and rockshelter sites, past investigations have 1) not attempted to formally test Flannery’s hypothesis, …

Development Of Mof@Polymer Composite Materials Through Bottom-Up Self-Assembly Techniques, Roberto Christian Arbulu

Chemistry and Chemical Biology ETDs

MOF-based mixed matrix membranes (MMMs) are a promising new class of MOF/polymer composite materials. Currently, fabrication of MMMs is based on top-down methods with limited control over MOF positioning, integration, or morphology. This work focuses on the growth of well-defined one-dimensional (1-D) MOF nanostructures within the pores of a nanoporous polymer template, either commercially available or through the self-assembly of block co-polymers having tailor-designed surface functionalities. Studies were conducted using zeolitic imidazole framework-8 (ZIF-8) and polycarbonate track etched (PCTE) membranes, which demonstrated the feasibility of the outlined approach, and revealed the formation of distinct super- and nanostructures with controlled morphologies …

Unm Pathology Pathfinder Summer 2018, Unm Department Of Pathology

Newsletters

No abstract provided.