Digital Commons Network^™

Uptake Of Co-Testing With Hpv And Cytology For Cervical Screening: A Population-Based Evaluation In The United States, Jack Cuzick, Ruofei Du, Rachael Adcock, Walter Kinney, Nancy Joste, Ruth M. Mcdonald, Kevin English, Salina M. Torres, Debbie Saslow, Cosette M. Wheeler

Pathology Research and Scholarship

OBJECTIVES: Human papillomavirus (HPV) testing for cervical screening has been shown to increase the yield of precancerous disease and reduce the incidence of cervical cancer more than cytology alone. Here we document the state-wide uptake of co-testing with HPV and cytology in women aged 30-64 years as recommended by national and international bodies.

METHODS: Registry-based study of all screening cytology and HPV tests in New Mexico from 2008 to 2019 among women aged 21-64 years, with a focus on cytology negative tests to distinguish co-testing from reflex HPV testing to triage equivocal or mildly abnormal cytology.

RESULTS: A total of …

Adherence To National Guidelines On Cervical Screening: A Population-Based Evaluation From A Statewide Registry, Philip E. Castle, Walter K. Kinney, Lu Chen, Jane J. Kim, Steven Jenison, Giovanna Rossi, Huining Kang, Jack Cuzick, Cosette M. Wheeler, New Mexico Hpv Pap Registry Steering Committee

Pathology Research and Scholarship

In 2012, national recommendations for cervical-cancer screening of women aged 30-64 years were quinquennial human papillomavirus and cytology co-testing or triennial cytology. Data from a state-wide surveillance program in New Mexico demonstrated 65.2% (95% confidence interval [95%CI]= 64.6%% to 65.7%) of women screened in 2019 had negative co-test within the last 3 years. Percentages of women screened in 2013, 2016, and 2019 with a prior negative co-test more than 5 and up to 7 years ago were 2.6% (95% CI = 2.2% to 2.9%), 2.1% (95% CI = 1.9% to 2.2%), and 6.5% (95% CI = 6.2% to 6.8%), respectively …

Current Advances In Transfusion Medicine 2020: A Critical Review Of Selected Topics By The Aabb Clinical Transfusion Medicine Committee, Elizabeth S. Allen, Claudia S. Cohn, Sara Bakhtary, Nancy M. Dunbar, Thomas Gniadek, Courtney K. Hopkins, Jessica Jacobson, Parvez M. Lokhandwala, Ryan A. Metcalf, Colin Murphy, Micah T. Prochaska, Jay S. Raval, Hua Shan, Emily K. Storch, Monica B. Pagano

Pathology Research and Scholarship

BACKGROUND: The AABB Clinical Transfusion Medicine Committee (CTMC) compiles an annual synopsis of the published literature covering important developments in the field of transfusion medicine (TM), which has been made available as a manuscript published in Transfusion since 2018.

METHODS: CTMC committee members reviewed original manuscripts including TM-related topics published electronically (ahead) or in print from December 2019 to December 2020. The selection of topics and manuscripts was discussed at committee meetings and chosen based on relevance and originality. Next, committee members worked in pairs to create a synopsis of each topic, which was then reviewed by two additional committee …

Rheumatic Heart Disease In The United States: Forgotten But Not Gone: Results Of A 10 Year Multicenter Review., Sarah R De Loizaga, Lindsay Arthur, Bhawna Arya, Brian Beckman, Wubishet Belay, Cole Brokamp, Nak Hyun Choi, Sean Connolly, Soham Dasgupta, Tavenner Dibert, Marylou M Dryer, Lakshmi R Gokanapudy Hahn, Elizabeth Anne Greene, Daphney Kernizan, Omar Khalid, Jennifer Klein, Ryan Kobayashi, Subhrajit Lahiri, Raymond P Lorenzoni, Andrea Otero Luna, Jennifer Marshall, Theodore Millette, Lily Moore, Babu Muhamed, Meghna Murali, Kinjal Parikh, Amy Sanyahumbi, Divya Shakti, Elizabeth Stein, Sanket Shah, Hannah Wilkins, Mcallister Windom, Scott Wirth, Meghan Zimmerman, Andrew F Beck, Nicholas Ollberding, Craig Sable, Andrea Beaton

Pediatrics Research and Scholarship

Background Recent evaluation of rheumatic heart disease (RHD) mortality demonstrates disproportionate disease burden within the United States. However, there are few contemporary data on US children living with acute rheumatic fever (ARF) and RHD. Methods and Results Twenty-two US pediatric institutions participated in a 10-year review (2008-2018) of electronic medical records and echocardiographic databases of children 4 to 17 years diagnosed with ARF/RHD to determine demographics, diagnosis, and management. Geocoding was used to determine a census tract-based socioeconomic deprivation index. Descriptive statistics of patient characteristics and regression analysis of RHD classification, disease severity, and initial antibiotic prescription according to community …

Longitudinal Assessment Of Cytokine Expression And Plasminogen Activation In Hantavirus Cardiopulmonary Syndrome Reveals Immune Regulatory Dysfunction In End-Stage Disease, Peter Simons, Yan Guo, Virginie Bondu, Susan L. Tigert, Michelle Harkins, Samuel Goodfellow, Cana Tompkins, Devon Chabot-Richards, Xuexian O. Yang, Laura Gonzalez Bosc, Steven Bradfute, Daniel A. Lawrence, Tione Buranda

Pathology Research and Scholarship

Pathogenic New World orthohantaviruses cause hantavirus cardiopulmonary syndrome (HCPS), a severe immunopathogenic disease in humans manifested by pulmonary edema and respiratory distress, with case fatality rates approaching 40%. High levels of inflammatory mediators are present in the lungs and systemic circulation of HCPS patients. Previous studies have provided insights into the pathophysiology of HCPS. However, the longitudinal correlations of innate and adaptive immune responses and disease outcomes remain unresolved. This study analyzed serial immune responses in 13 HCPS cases due to Sin Nombre orthohantavirus (SNV), with 11 severe cases requiring extracorporeal membrane oxygenation (ECMO) treatment and two mild cases. We …

Statistical Methods And Management Of Indeterminacy In Medical Sciences. Surgical Site Infection Study After Vascular Surgery Procedures, Carlos Acosta Mayorga, Piedad Elizabeth Acurio Padilla, Guillermo Bastidas Tello, Abdel Bermúdez Del Sol

Neutrosophic Sets and Systems

Surgical site infections (SSIs) are one of the main infection control problems in modern hospitals, significantly prolonging the stay at the hospital and increasing the cost of treating patients with infections. They are the leading cause of failure for both patients and staff, including the need for repeated surgeries. The objective of this study is the epidemiological and microbiological analysis, through neutrosophic statistical tools, of surgical site infections after vascular surgery in a highly specialized vascular surgery center in the city of Guayaquil, in which 327 vascular operations were performed, during the year 2019 and the follow-up of patients was …

Management Of Indeterminacy In The Analysis Of Knowledge About Reproductive Tract Infections In Women, Julio Morillo Cano, Melba Esperanza Narváez Montenegro, Adisnay Rodríguez Placencia, Olger Efraín Velastegui Naranjo

Neutrosophic Sets and Systems

The research aims to assess the level of knowledge about reproductive tract infections among women to apply statistical analysis of the probability of indeterminacy. The main methods and techniques used were: theoretical, analytical-synthetic, and inductive-deductive, while within the empirical are the survey, measurement, and statistical-mathematical. The sample was calculated using neutrosophic statistics and python interval arithmetic library. The results achieved are evaluated quantitatively and qualitatively, where the validity of the same was demonstrated since there was a level of significance equal to or less than p 0.05.

Shea Pediatric Leadership Council Commentary: Supporting Well Child Care During The Coronavirus Disease 2019 (Covid-19) Pandemic With Personal Protective Equipment In The Ambulatory Setting, Joshua K Schaffzin, Allison H. Bartlett, Latania K. Logan, Judith A Guzman-Cottrill, Carolyn Caughell, Karen A. Ravin, Lorry G. Rubin, Larry K. Kociolek, Martha L. Muller, Jason Lake, Lynn Ramirez-Avila, Shea Pediatric Leadership Council

Pediatrics Research and Scholarship

No abstract provided.

Virtual Peer-To-Peer Learning To Enhance And Accelerate The Health System Response To Covid-19: The Hhs Aspr Project Echo Covid-19 Clinical Rounds Initiative., Richard C. Hunt, Bruce B. Struminger, John T. Redd, Jack Herrmann, B Tillman Jolly, Sanjeev Arora, Amy J. Armistad, Amanda M. Dezan, Celine A. Bennett, Jon R. Krohmer, Lawrence H. Brown

Project ECHO Bibliography

Tasked with identifying digital health solutions to support dynamic learning health systems and their response to COVID-19, the US Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response partnered with the University of New Mexico's Project ECHO and more than 2 dozen other organizations and agencies to create a real-time virtual peer-to-peer clinical education opportunity: the COVID-19 Clinical Rounds Initiative. Focused on 3 "pressure points" in the COVID-19 continuum of care-(1) the out-of-hospital and/or emergency medical services setting, (2) emergency departments, and (3) inpatient critical care environments-the initiative has created a massive peer-to-peer learning …

Nanoscale Assembly Of Dectin-1 And Its Glucan Ligand In Immunocyte Membranes And Pathogen Cell Walls, Akram Etemadi Amin

Physics & Astronomy ETDs

Candida spp. pathogens continue to be a significant health care burden with high mortality and exceeding enormous healthcare costs. Candida infection range varies from dermatological infection to more severe bloodstream infection in debilitated patients. Due to this, research dedicated to understanding biophysical interactions between Candida species and the host’s immune cells is essential. The C-type lectin’s (CtLs) are known to bind to Candida cell walls and play a crucial role in downstream immune signaling. It is known that β-glucans, the highly immunogenic polysaccharide in Candida’s cell wall, are mostly masked underneath a layer of mannosylated proteins. The amount of …

Using Virus-Like Particles To Combat Cardiovascular Disease And Identify An Immunogenic Target Of Natural Zika Virus Infection In Humans, Alexandra Marie Fowler

Biomedical Sciences ETDs

Virus-like particles (VLPs) derived from bacteriophages have been utilized as highly immunogenic vaccine platforms for displaying antigen targets of interest. Bacteriophage VLPs have a highly repetitive structure made of protein subunits that self-assemble into an icosahedral particle. These structures can strongly activate the immune system, especially B cells. Arraying antigens on the surface of VLPs in a multivalent manner can, in turn, confer the ability to induce strong antibody responses to virtually any target. This technique can even be used to elicit antibody responses against self-antigens. Here we have exploited these features for developing VLP-based vaccines that target self-molecules involved …

Stronger Transition: Coping With Natural Disasters, And Health-Economic Investment For Adolescents In Developing Countries, Mengqi Liu

Economics ETDs

This dissertation investigates the period of adolescence as another important window for human capital development. The first chapter provides the introduction of my three research papers, highlighting the research motivation, goals, and contributions. The final chapter summarizes the conclusions and discusses the future research trajectory. The first paper examines the long-term health and socioeconomic implications of exposure to natural disasters during adolescence and childhood. In the second paper, I survey the current awareness of Human Papillomavirus (HPV) and HPV vaccine in Nepal and test the different indicators for HPV vaccination, precisely the mother’s intention to vaccinate their adolescent girls against …

Disability Injustice: A Latino’S Creative Autoethnographic Testimonio On The Organizational Culture Of Higher Education, Leonel A. Diaz Jr.

Organization, Information and Learning Sciences ETDs

Using creative autoethnographic testimonio (CAT), a story is told about the injustices within the learning environment and work environment of higher education toward a person with disabilities: sleep apnea, learning disabilities, negative mental health. The author explores the health difficulties of addressing sleep deprivation while attending graduate school and working full-time as a professional. With sleep apnea impacting his health, his mental health declines. As his health declines, there is an increase in discrimination, hostility, oppression, bullying, and toxic masculinity. Initially, the medical system dismisses his declining health and refuses to look further into it. Once he receives medical care …

Factors Influencing Rural Women’S Physical Activity Behaviors: A Social Ecological Perspective, Karen Lynn Webb

Nursing ETDs

ABSTRACT

Chronic disease and poor mental health are disproportionally impacting adults living in rural America. Regular physical activity has been shown to promote overall well-being and prevent many chronic diseases. Yet, research shows that many rural adults do not engage in enough physical activity to meet the recommended levels put forth by the federal government. The purpose of this descriptive qualitative study was to explore and describe the experiences of physical activity as perceived by rural women in their own words. Data were collected through semi-structured individual interviews of 20 women aged 25 to 34 living in McDowell County, West …

Post-Discharge Healthcare Utilization In Infants With Neonatal Opioid Withdrawal Syndrome, Shikhar Shrestha, Melissa H Roberts, Jessie R Maxwell, Lawrence M Leeman, Ludmila N Bakhireva

Pediatrics Research and Scholarship

The opioid epidemic in the United States has led to a significant increase in the incidence of neonatal opioid withdrawal syndrome (NOWS); however, the understanding of long-term consequences of NOWS is limited. The objective of this study was to evaluate post-discharge healthcare utilization in infants with NOWS and examine the association between NOWS severity and healthcare utilization. A retrospective cohort design was used to ascertain healthcare utilization in the first year after birth-related discharge using the CERNER Health Facts® database. ICD-9/ICD-10 diagnostic codes were used to identify live births and to classify infants into two study groups: NOWS and uncomplicated …

New Diagnosis Of X-Linked Agammaglobulinemia Presenting As Multi-Focal Acute Pseudomonal Osteomyelitis And Septic Arthritis In A 16-Month Old Boy: A Case Report, Walter Dehority

Western Journal of Orthopaedics

A previously healthy 16-month-old boy presented with 5 days of fever, a limp favoring his right side, and swelling and erythema of the dorsal left foot and left great toe. Contrasted magnetic resonance imaging revealed septic arthritis of the left knee, the interphalangeal joint of the left great toe, and the left subtalar and ankle joints. He had osteomyelitis of the left talus and intraosseous abscess formation in the left calcaneus. Cultures of the blood, left knee synovial fluid, and abscess fluid all showed growth of Pseudomonas aeruginosa. He was subsequently diagnosed with X-linked agammaglobulinemia with a novel mutation in …

20210621_New Library Resource- You Now Have Access To Clinicalkey, Laura J. Hall

HSLIC Blog Post

No abstract provided.

Quality Improvement And Patient Care Symposium 2021 Program, Office For Continuous Professional Learning

Quality Improvement/Patient Safety Symposium

No abstract provided.

The Role Of Comorbidities And Social Determinants Of Health In Patients With Covid-19 In New Mexico, Lauren Epler, Tenzin Desel, Ariana Thompson, Samantha Paltrow-Krulwich, Susie Pham, Diamone Gathers Md, Krystal Chan Md

Quality Improvement/Patient Safety Symposium

Introduction

Comorbidities are associated with higher levels of morbidity and mortality in patients with COVID-19 infection. Minorities have been disproportionately affected by COVID-19. Additionally, minorities have high rates of comorbidities.

Methods

Students surveyed consented patients on RedCap who tested positive for COVID-19 infection and were seen in the UNM COVID-Follow up Clinic between April-October 2020 via telephone.

Results

125 patients. 52% Hispanic/Latino, 23% American Indian/Alaska Native, 16% white, 3% African American, 1% Asian, and 5% multiple race/ethnicities. 16% had vaped nicotine, 15% had vaped marijuana or cannabis, and 33% had smoked at least 100 cigarettes in their lifetime. 23% had …

Anal Cancer Screening At Truman Health Services, Peter D. Tran, Harshdeep Babbar

Quality Improvement/Patient Safety Symposium

Anal Papanicoloau Screening at Truman Clinic

Anal cancer is a squamous cell cancer associated with human papillomavirus (HPV), the same virus that is associated with cervical cancer. Although vaccination against HPV has been shown to be effective in reducing overall rates of infection, the number of new anal cancer cases has been rising for many years. In HIV-infected men and women, the incidence is even higher of anal cancer than in the general population. Current rates in an HIV-infected MSM population have been estimated to be as high as 70-144 per 100,000, with some studies of HIV-infected individuals showing that …

Memory Care Approaches To Better Leverage Capacity Of Dementia Specialists: A Narrative Synthesis, Jenny Lam, Soeren Mattke

Project ECHO Bibliography

Prior research suggests that a scarcity of dementia specialists could hamper access to disease-modifying Alzheimer’s treatments. We describe alternative approaches on how to leverage specialist time for memory care in this narrative synthesis based on 17 semi-structured interviews and a targeted literature review on memory care approaches that leverage specialist time. We identified four types of approaches: community primary care practices empowered with better tools and training; primary care memory clinics; specialty memory clinics and; specialty memory centers. Several approaches to use specialist time efficiently have been implemented and some but not all evaluated. The optimal approach may depend on …

Efficacy Of As04-Adjuvanted Vaccine Against Human Papillomavirus (Hpv) Types 16 And 18 In Clearing Incident Hpv Infections: Pooled Analysis Of Data From The Costa Rica Vaccine Trial And The Patricia Study, Joseph E. Tota, Frank Struyf, Allan Hildesheim, Paula Gonzalez, Martin Ryser, Rolando Herrero, John Schussler, Naveen Karkada, Ana Cecilia Rodriguez, Nicolas Folschweiller, Carolina Porras, Mark Schiffman, John T. Schiller, Wim Quint, Aimée R. Kreimer, Matti Lehtinen, Cosette M. Wheeler, Joshua N Sampson

Pathology Research and Scholarship

Clinical trial data and real-world evidence suggest that the AS04-adjuvanted vaccine targeting human papillomavirus types 16 and 18 (AS04-HPV-16/18) vaccine provides nearly 90% protection against cervical intraepithelial neoplasia grade 3 or higher irrespective of type, among women vaccinated before sexual debut. This high efficacy is not fully explained by cross-protection. Although AS04-HPV-16/18 vaccination does not affect clearance of prevalent infections, it may accelerate clearance of newly acquired infections. We pooled data from 2 large-scale randomized controlled trials to evaluate efficacy of the AS04-HPV-16/18 vaccine against clearance of nontargeted incident infections. Results of our analysis do not suggest an effect in …

Health Impacts Of Wildfire Smoke As A Consequence Of Climate Change And Recommendations For Public Health Officials And The General Public In The Albuquerque Metropolitan Area, Jegason Diviant

Climate Change and Public Health Preparedness

No abstract provided.

Effects Of Message Frame And Cultural Orientations On Covid-19 Prevention Behaviors, Mika Hashimoto

Communication ETDs

This study aimed to explore effective message strategies to promote COVID-19 prevention behaviors among college students. Due to the fewer symptoms and lessened impact of COVID-19 in this population, young adults tend to have low perceived risk that results in low engagement in preventive behaviors. Also, some people may hold beliefs or values that are contrary to preventive behaviors. Thus, applying message framing theory, this study tested the effects of perceived risk and cultural orientation on adherence to prevention behaviors. The results showed that perceived risk and cultural orientation were associated with intention to maintain physical distance and wearing a …

Immunodeficiency And Bone Marrow Failure With Mosaic And Germline Tlr8 Gain Of Function, Jahnavi Aluri, Alicia Bach, Saara Kaviany, Luana Chiquetto Paracatu, Maleewan Kitcharoensakkul, Magdalena A. Walkiewicz, Christopher D. Putnam, Marwan Shinawi, Nermina Saucier, Elise M. Rizzi, Michael T. Harmon, Molly P. Keppel, Michelle Ritter, Morgan Similuk, Elaine Kulm, Michael Joyce, Adriana A. De Jesus, Raphaela Goldbach-Mansky, Yi-Shan Lee, Marina Cella, Peggy L. Kendall, Mary C. Dinauer, Jeffrey J. Bednarski, Christina Bemrich-Stolz, Scott W. Canna, Shirley M. Abraham, Matthew M. Demczko, Jonathan Powell, Stacie M. Jones, Amy M. Scurlock, Suk See De Ravin, Jack J. Bleesing, James A. Connelly, V Koneti Rao, Laura G. Schuettpelz, Megan A. Cooper

Pediatrics Research and Scholarship

Inborn errors of immunity (IEI) are a genetically heterogeneous group of disorders with a broad clinical spectrum. Identification of molecular and functional bases of these disorders is important for diagnosis, treatment, and an understanding of the human immune response. We identified 6 unrelated males with neutropenia, infections, lymphoproliferation, humoral immune defects, and in some cases bone marrow failure associated with 3 different variants in the X-linked gene TLR8, encoding the endosomal Toll-like receptor 8 (TLR8). Interestingly, 5 patients had somatic variants in TLR8 with

Hepatitis C Elimination Among People Incarcerated In Prisons: Challenges And Recommendations For Action Within A Health Systems Framework, Matthew J. Akiyama, Nadine Kronfli, Joaquin Cabezas, Yumi Sheehan, Prem H. Thurairajah, Richard Lines, Andrew R. Lloyd, International Network On Health And Hepatitis In Substance Users–Prisons Network

Project ECHO Bibliography

Hepatitis C virus (HCV) is a global public health problem in correctional settings. The International Network on Health and Hepatitis in Substance Users–Prisons Network is a special interest group committed to advancing scientific knowledge exchange and advocacy for HCV prevention and care in correctional settings. In this Review, we highlight seven priority areas and best practices for improving HCV care in correctional settings: changing political will, ensuring access to HCV diagnosis and testing, promoting optimal models of HCV care and treatment, improving surveillance and monitoring of the HCV care cascade, reducing stigma and tackling the social determinants of health inequalities, …

Variability In The Use Of Novel Diagnostic Technology In Children With Suspected Encephalitis And In The Management Of Emerging Encephalitides By Pediatric Infectious Disease Providers, Walter N. Dehority, Andrew B. Janowski, Kevin Messacar, Philip M. Polgreen, Susan E. Beekmann

Pediatrics Research and Scholarship

We surveyed pediatric infectious disease physicians through the Infectious Disease Society of America's Emerging Infections Network regarding the diagnosis and management of encephalitis. We identified practice variations, particularly with the use of new diagnostic modalities and management of autoimmune encephalitides. These findings may inform the creation of updated management guidelines.

Heterogeneity In Hosts And Environment: Implications For Schistosomiasis Control, Larissa Celeste Anderson

Biology ETDs

Schistosomiasis is a widespread neglected parasitic disease, endemic in 54 countries, for which 290 million people needed treatment in 2018. A major Schistosoma species, Schistosoma mansoni, is sustained via a life cycle that includes both human and snail hosts. Mathematical models of S. mansoni transmission are an integral tool for elucidating the complexities of the transmission cycle, interactions between parasite species and for the estimation of the impact of intervention efforts. We designed both deterministic and stochastic mathematical models to understand the impact of heterogeneity in host and parasite composition on projected infection control. These models indicate the impact of …

Silver Diamine Fluoride: Preventing Dental Caries, Renee S. Bingman

Dental Hygiene ETDs

Purpose

The study was designed to determine awareness and knowledge of silver diamine fluoride (SDF) among dental hygiene program directors and determine if schools have included SDF education to their curriculum.

Methods

A descriptive survey was used to gather information from all United States dental hygiene program directors.

Results

The survey had a max response from 39 school directors. With 92.31% of schools indicating SDF as a product of interest only 76.92% currently provided education to students. There are 76.92% of schools providing SDF education to students yet only 34.21% of those schools are providing SDF education to the faculty. …

Exploring The Interaction Of Amphiphilic Mycobacterial Lipoarabinomannan With Lipoproteins: Implications For Blood-Based Diagnosis, Shailja Jakhar

Biomedical Sciences ETDs

Currently, over one-third of the global population is infected with tuberculosis (TB), one of the world’s most deadly infectious diseases. The current gold standard for TB diagnosis is microbiological culture, which can take up to 6-8 weeks, which is not conducive to timely treatment. There are no reliable diagnostics for TB. Disease manifestation and outcome of diagnostic tests for TB are influenced by co-morbidities such as HIV co-infection, further complicating diagnostics development. Thus, there is a need for reliable diagnostics for TB. This is especially true in pediatric populations where the differential disease presentation further complicates outcomes.

This dissertation describes …