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Identity, Sexuality, And Gender: Perspectives From Self-Identified Sexually Fluid People, Mattilyn Wiseman May 2026

Identity, Sexuality, And Gender: Perspectives From Self-Identified Sexually Fluid People, Mattilyn Wiseman

Psychology ETDs

Research on sexual fluidity has relied on categorical, gender-based measurement frameworks that prioritize quantifying change over exploring the lived experience of sexually fluid people. This study employed Interpretive Phenomenological Analysis (IPA) to qualitatively and ideographically explore how self-identified sexually fluid people made sense of their own sexual identity, gender (more broadly), and attraction as it relates or does not relate to gender. Three participants completed structured interviews with open-ended questions. Participants unanimously made sense of identity as a self-constructed journey and tied to their social realities. Participants’ lived experiences of their own gender identities informed their sense-making of gender more …


The Concept 'Pollination' And Bee Pan-Trap Color And Uv Reflectance Determine The Taxonomic Compositions Of Bee Taxa Captures Across An Elevation Gradient And Seasons In The Jemez Mountains Of New Mexico, Esther A. Burton, Kelly B. Miller, Paul J. Watson, David C. Witherington, Steven Poe, David Lightfoot May 2026

The Concept 'Pollination' And Bee Pan-Trap Color And Uv Reflectance Determine The Taxonomic Compositions Of Bee Taxa Captures Across An Elevation Gradient And Seasons In The Jemez Mountains Of New Mexico, Esther A. Burton, Kelly B. Miller, Paul J. Watson, David C. Witherington, Steven Poe, David Lightfoot

Biology ETDs

This thesis examines the pollinator concept and tests how sampling methods shape bee communities. Chapter 1 provides a conceptual and philosophical analysis, arguing that pollination is a process and that pollinators are context-dependent functional roles rather than fixed taxonomic categories. It traces the concept’s development from natural history to ecological theory, introduces a dual-goal model separating plant reproduction from visitor foraging, and proposes a classification framework based on evidentiary certainty and pollination potential to resolve ambiguity in pollination research.

Chapter 2 applies these ideas empirically by evaluating how pan-trap color and ultraviolet (UV) reflectance influence bee assemblages across elevation and …


From Cranes To Clinics: Genomic Epidemiology At The Human-Animal Interface, Sarah Shrum May 2026

From Cranes To Clinics: Genomic Epidemiology At The Human-Animal Interface, Sarah Shrum

Biology ETDs

Emerging infectious diseases represent a significant, increasing threat to human life, economic stability, and global security. The One Health framework, which promotes human health and wellness through the understanding that animal, environmental, and human health are interwoven, is critical to understanding pathogen emergence and transmission. This is underscored by the fact that roughly 60% of all human pathogens and 75% of emerging infectious disease are zoonotic, meaning they are transmitted from animals to humans.

The work presented in this dissertation integrates genomic epidemiology, ecological analysis, and One Health Surveillance approaches to characterize cross-species circulation of opportunistic yeast pathogens (Candida …


Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez May 2026

Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez

Psychology ETDs

Fetal Alcohol Spectrum Disorders involve morphologic and neurobiological abnormalities in offspring subjected to prenatal alcohol exposure. Although not as well studied as high exposure, moderate prenatal alcohol exposure represents the most common and undetected form in humans. While learning and memory deficits have been well characterized at the behavioral level in humans with Fetal Alcohol Spectrum Disorders and in animal models of moderate prenatal alcohol exposure, few studies have determined the circuit or systems level mechanisms of the behavioral deficits. A complete understanding of the neural bases of memory deficits after moderate prenatal alcohol exposure is needed to ultimately identify …


Torá: A Description Of A Dormant Chapacuran Language From Legacy Materials, Akasha Synclair May 2026

Torá: A Description Of A Dormant Chapacuran Language From Legacy Materials, Akasha Synclair

Linguistics ETDs

Torá, an Amazonian language of the Chapacuran family, went dormant as the Torá people survived colonization. Yet, in the early 1920’s, over 600 Torá words, phrases, and sentences were documented. Despite interest by today’s Torá community in language revitalization, no comprehensive analysis of the data has been undertaken. This project used methods of linguistic reconstitution, cross linguistic comparison, and the creation of an open-access database to produce a phonological and morphosyntactic analysis of Torá. Phonological findings of particular interest include evidence for vowel harmony and variable oralization of nasals. In structure, Torá is very similar to related languages, displaying a …


The Effect Of Acute Hypoxia Exposure, With Exercise, On Bone Metabolic Biomarkers, Alyssa Bailly May 2026

The Effect Of Acute Hypoxia Exposure, With Exercise, On Bone Metabolic Biomarkers, Alyssa Bailly

Health, Exercise, and Sports Sciences ETDs

Hypoxic environments, resulting from decreased atmospheric partial pressure of oxygen, reduce oxygen availability in the blood and tissues, leading to a mismatch between supply and demand. This elicits several physiological adaptations and may influence bone metabolism. Although evidence suggests that hypoxia can modulate bone remodeling through hypoxia-inducible pathways, findings remain mixed, with most data derived from chronic hypoxic exposures in animal and cell culture models. Exercise, an essential stimulus for bone health, may exacerbate hypoxic stress; however, the skeletal response to acute hypoxic exposure combined with exercise remains unclear. We propose that intermittent exercise in hypoxia may increase negative markers …


Benefits Of Advisory & Culturally Responsive Advisory Framework (Craf) Within A Southwestern, Urban, Dual Language Middle School, Mariana Anguelova Castañon May 2026

Benefits Of Advisory & Culturally Responsive Advisory Framework (Craf) Within A Southwestern, Urban, Dual Language Middle School, Mariana Anguelova Castañon

Language, Literacy, and Sociocultural Studies ETDs

In this research report, I examine the benefits of a daily Advisory period at a southwestern, urban, dual-language middle school and explore the impact of the Culturally Responsive Advisory Framework (CRAF), a curriculum I developed as a researcher-practitioner. This work is situated within research on Advisory programs, urban schooling, and dual-language education, while addressing implementation challenges. Grounded in democratic learning theory, CRAF integrates social-emotional learning (SEL), social-cultural learning (SCL), and literacy. To evaluate its impact, I collected qualitative data through anonymous Google Surveys and semi-structured student interviews, supported by quantitative teacher and student surveys. Data were analyzed using open and …


Shelter From The Storm: Public Library Value And Community Adaptive Capacities, Margo Gustina May 2026

Shelter From The Storm: Public Library Value And Community Adaptive Capacities, Margo Gustina

Economics ETDs

This dissertation contributes to theoretical framing within the discipline of library science, while building out empirical methods for quantitatively valuing broadly loved public libraries. Chapter 1 lays the foundation for understanding how analysis public libraries must always be set within regional contexts. Chapter 2 demonstrates that positive voter valuation of public libraries is driven by proximity to a library building by using data from public funding referendum events. Chapter 3 estimates a reduction of 0.75 percentage point (p=0.002) in graduation rates where public libraries were closed (but school instruction was in-person) from COVID closures. Chapter 4 builds on the previous …


Perception, Payment, And Pollution- Examining The Effects Of Air Quality On Health And Healthcare, Colin Sleeper May 2026

Perception, Payment, And Pollution- Examining The Effects Of Air Quality On Health And Healthcare, Colin Sleeper

Economics ETDs

Abstract

This dissertation examines how air quality and public attention to environmental shock affect perceived health status and healthcare utilization. The first chapter uses publicly available survey data from BRFSS and a triple difference framework to analyze the effects of the 2018 wildfire season in Oregon on self-reported mental and physical health. Findings indicate that those in Oregon in 2018, during the period of heightened attention to wildfire smoke, experienced approximately 1.4 additional poor mental health days, on average. The second chapter includes Merative MarketScan commercial insurance claims data to test whether these changes translate into a behavioral response. Results …


Agricultural Water Management, Farmer Decision-Making And Climate Adaptation In Dryland Agriculture: A Case Of The Middle Rio Grande Basin, Oluwatosin A. Olofinsao May 2026

Agricultural Water Management, Farmer Decision-Making And Climate Adaptation In Dryland Agriculture: A Case Of The Middle Rio Grande Basin, Oluwatosin A. Olofinsao

Economics ETDs

Agriculture in dryland regions faces mounting pressure from climate change, water scarcity, and shifting land-use demands. The Middle Rio Grande Basin (MRGB) of central New Mexico exemplifies these challenges, where irrigated agriculture relies on increasingly variable surface water supplies. This dissertation examines agricultural water use, farmer decision-making, and adaptation strategies across farm types and climate conditions in the MRGB. The first study presents a spatial descriptive analysis of farm size, crop patterns, groundwater access, evapotranspiration (ET), and effective ET, revealing a landscape numerically dominated by smallholder farms that account for a substantial share of irrigation water use. The second study …


The Formation Of Indian Health Services Within Imperial And Settler-Colonial Contexts, Jillian E. Grisel May 2026

The Formation Of Indian Health Services Within Imperial And Settler-Colonial Contexts, Jillian E. Grisel

American Studies ETDs

This dissertation examines the Indian Health Services as a Cold War biosecurity apparatus, showing how infectious disease was weaponized to dismantle treaty obligations, reorganize tribal lands into “service areas,” and reclassify Indigenous nations as surveilled populations. Against this carceral health economy, Indigenous nations refused. From the 1969 Alcatraz occupation to the 1976 Puyallup takeover of Cushman Indian Hospital, Native activists reclaimed health facilities as sovereign spaces, insisting that care is not a discretionary service but a treaty right grounded in land and kinship. Methodologically, I combine historical-legal analysis of congressional debates, Public Health Service reports, and IHS data with counter-archives …


Impact Of Third Trimester Alcohol Exposure (Ttae) On Oligodendrocyte Development And Behavior In Mice, Estrella Villicana May 2026

Impact Of Third Trimester Alcohol Exposure (Ttae) On Oligodendrocyte Development And Behavior In Mice, Estrella Villicana

Biomedical Sciences ETDs

Prenatal alcohol exposure (PAE) during late gestation can cause cognitive, behavioral, and motor impairments associated with fetal alcohol spectrum disorders (FASDs). The third trimester corresponds to a critical period of brain growth and maturation. This study examined the effects of Third Trimester-equivalent Alcohol Exposure (TTAE) on oligodendrocyte development and adult behavior. Neonatal mice were exposed to ethanol or air vapor from postnatal day (P) 4–8. Immunohistochemical analyses were performed at P8 and P30 to assess myelination, apoptosis, and oligodendrocyte lineage progression. TTAE significantly reduced myelin basic protein (MBP) expression at P8, which was recovered by P30, indicating delayed developmental myelination. …


Design And Optimization Of Epitope Based Malaria Vaccine Targeting Pre-Erythrocytic Stage, Yogesh Nepal May 2026

Design And Optimization Of Epitope Based Malaria Vaccine Targeting Pre-Erythrocytic Stage, Yogesh Nepal

Biomedical Sciences ETDs

Malaria remains a major global health challenge. Currently available vaccines provide only modest and transient protection. In this work, we developed virus like particles (VLPs) based vaccine to target vulnerable epitopes of circumsporozoite protein, a key surface protein of pre-erythrocytic sporozoite stage, across different structural contexts. The immunogenicity of these highly immunogenic vaccines were further enhanced using immune stimulating agents, adjuvants, and the most promising VLP and adjuvant combinations were evaluated in preclinical challenge models to assess efficacy. In parallel, we performed research in an antigen agonistic manner using VLP library immunization that displays different fragments of a target protein …


Assessing Uranyl-Specific Dnazymes And Dna-Aptamers For Uranium Binding In Environmentally Relevant Waters, Ashley R. Apodaca-Sparks May 2026

Assessing Uranyl-Specific Dnazymes And Dna-Aptamers For Uranium Binding In Environmentally Relevant Waters, Ashley R. Apodaca-Sparks

Civil Engineering ETDs

The legacy of uranium mining affects many communities in the western United States, resulting in elevated levels of uranium in surface water. The ability to quickly and accurately detect uranium on site in affected communities can lead to real-time water quality analysis that informs risk assessment and remediation efforts. The objective of this work is to advance the application of biosensing technologies for the measurement of uranium in waters affected by mining legacy. The third chapter of this thesis compares ANDalyze by AlpHa Instruments, a commercially available uranium biosensor, and inductively coupled plasma mass spectrometry (an EPA-verified method for uranium …


Unpacking The Roots Of School Vouchers: A Critical Discourse Analysis Of Its Origins And The Arizona Model, Swechha Singh May 2026

Unpacking The Roots Of School Vouchers: A Critical Discourse Analysis Of Its Origins And The Arizona Model, Swechha Singh

Language, Literacy, and Sociocultural Studies ETDs

Critical Race Theory (CRT) gained prominence in mainstream political discourse following President Trump issuance of Executive Order 13950, Combating Race and Sex Stereotyping, which intensified political debate surrounding CRT, diversity initiatives, and educational curricula. This study used Fairclough’s Critical Discourse Analysis to examine how ideological forces gave rise to the enactment of school vouchers. Using CRT as a theoretical lens, the study examined historical and contemporary data to explore how ideology functioned to advance an expansive education policy agenda, including Arizona’s Empowerment Scholarship Account program. This study offers evidence of the impact of the anti-CRT movement, as well as sustained …


Brain-Based Mechanisms Of Behavioral Impairment In Fetal Alcohol Spectrum Disorder (Fasd): The Neuroimaging Biomarkers Of Inhibitory Control, Zinia Pervin May 2026

Brain-Based Mechanisms Of Behavioral Impairment In Fetal Alcohol Spectrum Disorder (Fasd): The Neuroimaging Biomarkers Of Inhibitory Control, Zinia Pervin

Biomedical Engineering ETDs

The developing brain is highly susceptible to alcohol-induced toxicity, often resulting in long-term deficits in executive function and behavioral regulation. Inhibitory control impairments are among the most prominent deficits observed in Fetal Alcohol Spectrum Disorder (FASD). This study investigated the neural mechanisms of inhibitory dysfunction using a multimodal MEG–DTI approach in 67 children aged 6–8 years (34 with FASD, 33 controls) who performed a Go/No-Go task. Source-level MEG analyses revealed reduced stimulus-locked cortical activation in the anterior cingulate cortex and significant group-by-hemisphere interactions in the superior parietal cortex and cuneus. Time–frequency analyses showed diminished response-locked beta power in the sensory-motor …


Policy Concerning Student Use Of Magnification Loupes By American Dental Hygiene Schools, Amye M. Burruss May 2026

Policy Concerning Student Use Of Magnification Loupes By American Dental Hygiene Schools, Amye M. Burruss

Dental Hygiene ETDs

This descriptive study was to assess whether dental hygiene schools require students to purchase magnification loupes, at what point in the program they implement the use of loupes, and which type of loupes they require students to purchase. A survey link through Microsoft Forms consisting of nineteen multiple-choice questions was emailed to 327 dental hygiene program directors and was open for a total of three weeks. With a response rate of 13% (45 respondents), results indicate that most dental hygiene programs mandate or strongly encourage the use of magnification loupes and allow students to start wearing loupes in the first …


Blockade Logic: Settler Consciousness And The Petro-Security Apparatus, Sarah Seroy May 2026

Blockade Logic: Settler Consciousness And The Petro-Security Apparatus, Sarah Seroy

Communication ETDs

This study examines contemporary CID legislation and surrounding political rhetoric in Canada and its implications for Indigenous communities. It reveals how settler consciousness is affirmed through such legislation and how discourse rooted in colonial logics serves to strengthen Canada’s petro-security apparatus. Drawing from Teun van Dijk’s (1995) method of Ideological Discourse Analysis and integrating Indigenous epistemologies, it offers a research approach of anticolonial discourse analysis. This analysis reveals CID legislation as a racialized, colonial tool and a form of biopower the settler-state exerts over Indigenous communities. It normalizes settler-state hegemony and justifies the ongoing dispossession of Indigenous communities. This study …


Nuclear Deterrence: Enhancing The Mission Through Smart Factory Predictive Solutions, Jarrod Matthew Ronquillo May 2026

Nuclear Deterrence: Enhancing The Mission Through Smart Factory Predictive Solutions, Jarrod Matthew Ronquillo

Chemical and Biological Engineering ETDs

To meet the stewardship and modernization initiatives set by the Department of Energy new technologies must enter the manufacturing facilities within the nuclear deterrent complex. Predictive solutions begin with collecting data. An equipment health monitoring device was created to streamline data collection and organization for equipment and processes. A predictive and process performance dashboard was developed for a deionized water system. The dashboard used Western Electric statistical process rules and a machine learning regression algorithm to predict when the resistivity would fall out of specification. Lastly, a remaining useful life calculation was developed for all equipment related to nuclear deterrent …


The Role Of Gender And Salient Social Identities In Producing Vulnerability And Maladptation To Flooding In Koraso, Berekum, Ghana, Kingsley Damoah Oppong May 2026

The Role Of Gender And Salient Social Identities In Producing Vulnerability And Maladptation To Flooding In Koraso, Berekum, Ghana, Kingsley Damoah Oppong

Geography ETDs

This paper highlights how social identities like polygamy, illiteracy, and ethnicity hinder rural women farmers in Ghana from adapting to climate change. It advocates for an intersectional approach to address these challenges, moving beyond simplistic gender binaries. Using qualitative interviews (n=49) in a flood-prone village in Berekum, Ghana, the study reveals how these identities intersect with gender roles and colonial legacies, exacerbating vulnerability. It bridges Black feminist thought with climate change, an underexplored area, offering insights into climate change and environmental studies, as well as Black feminist scholarship. This research urges a reevaluation of how we understand climate change in …


Exploring Policy Change To Support Early Diagnosis Of Congenital Heart Defects (Chd) In New Mexico, Kelsey Carson Leibenhaut May 2026

Exploring Policy Change To Support Early Diagnosis Of Congenital Heart Defects (Chd) In New Mexico, Kelsey Carson Leibenhaut

Doctor of Nursing Practice Scholarly Projects

Congenital heart disease (CHD) is not a new or rare problem; it has likely always been a leading cause of childhood morbidity and mortality and clocks in today as the most frequently occurring birth defect, affecting an estimated 1 in 100 newborns (CDC, 2025). Prior to the middle of the 20th century, there was little to be done about CHD, as no treatments existed. Everything changed with the advancement of options for surgical repair of CHDs, significantly prolonging lifespans and improving quality of life for affected individuals. Despite these incredible advancements, babies are born with CHD every day, leading to …


Dungeons And Dragons As Game-Based Learning, Moses Allen May 2026

Dungeons And Dragons As Game-Based Learning, Moses Allen

Language, Literacy, and Sociocultural Studies ETDs

This phenomenological qualitative study explored the use of the Dungeons and Dragons (D&D) Role-Playing Game as a Game-Based Learning (GBL) model, measuring middle school student perceptions of engagement, motivation, and skill development through interactive storytelling. The study used a Practitioner Research theoretical framework and Thematic Analysis to identify emergent themes from the collected data. The study included gameplay of D&D after school with a small group of participants grades 6-8. Results indicated that participants reported consistently high levels of motivation and engagement. Participants perceived that D&D gameplay promoted the development of 21st Century Skills and middle school curricula skills, specifically …


A Planetary Health Approach To Address Food Insecurities In New Mexico, Mariah Kennell May 2026

A Planetary Health Approach To Address Food Insecurities In New Mexico, Mariah Kennell

Doctor of Nursing Practice Scholarly Projects

Food insecurity remains a persistent public health concern throughout New Mexico, impacting both rural and urban populations and contributing to significant health disparities. Limited access to affordable, locally sourced fresh foods exacerbates chronic disease burden and undermines community health. The purpose of this Doctor of Nursing Practice project was to conduct a comprehensive policy analysis to identify feasible state-level strategies to improve food access through strengthening local food systems. Using the Centers for Disease Control and Prevention POLARIS policy analysis framework, a structured evaluation of existing and potential state and community-level policies was conducted. The analysis incorporated stakeholder interviews with …


Ambient Air Pollution In New Mexico: Nurse Practitioner Awareness, Mckenzie Hemmes, Grayson Kemp May 2026

Ambient Air Pollution In New Mexico: Nurse Practitioner Awareness, Mckenzie Hemmes, Grayson Kemp

Doctor of Nursing Practice Scholarly Projects

Ambient air pollution is a significant public health concern in New Mexico and contributes to respiratory disease, cardiovascular illness, and adverse pregnancy outcomes (Dominski et al., 2021; Di et al., 2022). Despite well-established evidence linking environmental exposures to health outcomes, environmental exposure screening is not routinely incorporated into clinical practice. The purpose of this Doctor of Nursing Practice (DNP) project was to improve environmental health literacy (EHL) among advanced practice registered nurses (APRNs) in New Mexico and to increase their intention to integrate ambient air pollution exposure screening and mitigation counseling into routine clinical practice. A virtual educational intervention guided …


Exploring Policy Change To Support Early Diagnosis Of Congenital Heart Disease (Chd) In New Mexico, Kelsey Carson Leibenhaut May 2026

Exploring Policy Change To Support Early Diagnosis Of Congenital Heart Disease (Chd) In New Mexico, Kelsey Carson Leibenhaut

Doctor of Nursing Practice Posters and Presentations

Congenital heart disease (CHD) is not a new or rare problem; it has likely always been a leading cause of childhood morbidity and mortality and clocks in today as the most frequently occurring birth defect, affecting an estimated 1 in 100 newborns (CDC, 2025). Prior to the middle of the 20th century, there was little to be done about CHD, as no treatments existed. Everything changed with the advancement of options for surgical repair of CHDs, significantly prolonging lifespans and improving quality of life for affected individuals. Despite these incredible advancements, babies are born with CHD every day, leading to …


The Las Cruces International Mariachi Conference: Breaking Down Constructed Borderlands, Melissa Rios May 2026

The Las Cruces International Mariachi Conference: Breaking Down Constructed Borderlands, Melissa Rios

Music ETDs

Despite its significant contribution to the educational mariachi movement in the United States, the history of the Las Cruces International Mariachi Conference (LCIMC), established in 1994, remains largely absent from existing scholarship. This study offers a historical account of mariachi music in Las Cruces and the development of the LCIMC, establishing a foundation for future research on mariachi music in the Mesilla Valley. Distinct from other mariachi conferences that emerged at the turn of the 21st century, the LCIMC was shaped by its location in a border city in New Mexico. Conceptualizing both physical borders and metaphorical border spaces as …


Getting Started With Orcid, Will White May 2026

Getting Started With Orcid, Will White

PIE CHART

No abstract provided.


The "Confidential Whispers" Of Charles Francis Adams From His Teens Through Marriage At Age 22, Mitchell Jay Freedman May 2026

The "Confidential Whispers" Of Charles Francis Adams From His Teens Through Marriage At Age 22, Mitchell Jay Freedman

History ETDs

The early diaries and letters of Charles Francis Adams (1807-1886) reveal, contrary to previous scholarship, a passionate and sensitive young man engaged in multiple social activities with male and female friends and family, as well as enjoying licentious and respectful personal relationships with women. CFA was strategic with whom he was friendly or reserved, rooted in his hostility towards “hangers-on” and “hypocrites.” CFA also read widely both fiction and non-fiction with an affected sensitivity consistent with his desire for a literary-oriented life, the latter most reflected in his later curating his forebears’ papers. CFA’s early life experiences led CFA to …


A Scoping Review Of Empirical Research On Post-Retraction Citation, Will White, Caitlin Bakker, Susmita Das, Yuanxi Fu, Esther Hsiao, Jess Rogovin, Jodi Schneider May 2026

A Scoping Review Of Empirical Research On Post-Retraction Citation, Will White, Caitlin Bakker, Susmita Das, Yuanxi Fu, Esther Hsiao, Jess Rogovin, Jodi Schneider

Posters and Presentations

This scoping review examines post-retraction citations as a proxy for epistemic risk (i.e., the likelihood that one holds a false or inaccurate belief). It aims to describe the current landscape of empirical research on post-retraction citation, with the specific aim of determining the extent of epistemic risk and describing how that risk may manifest and result in epistemic harm.


From Synapse To Circuit: Mechanisms Of Behavioral Flexibility And Its Restoration After Prenatal Alcohol Exposure, Jayapriya Chandrasekaran May 2026

From Synapse To Circuit: Mechanisms Of Behavioral Flexibility And Its Restoration After Prenatal Alcohol Exposure, Jayapriya Chandrasekaran

Biomedical Sciences ETDs

Behavioral flexibility—the ability to adapt behavior when contingencies change—is a fundamental executive function supported by orbitofrontal–striatal circuitry. This dissertation examined molecular, motivational, and circuit mechanisms underlying flexibility and its restoration after prenatal alcohol exposure (PAE). In healthy mice, GluN2B-containing NMDA receptors in the orbitofrontal cortex increased during outcome updating, while AMPA receptor subunits in the dorsal striatum rose during new learning, defining temporally distinct plasticity processes. PAE impaired reversal learning under low-reward conditions, but not when motivation was high, indicating altered thresholds for circuit engagement rather than permanent loss. Finally, optogenetic stimulation of OFC→dorsal striatum projections rescued flexibility in PAE …